BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
348227	C[C@@H]1CN(Cc2c1n(nc2C(=O)Nc3cccc(c3)[C@H](C)O)Cc4ccc(cc4)F)C(=O)c5ccc[nH]5	InChI=1S/C28H28FN5O3/c1-17-14-33(28(37)24-7-4-12-30-24)16-23-25(27(36)31-22-6-3-5-20(13-22)18(2)35)32-34(26(17)23)15-19-8-10-21(29)11-9-19/h3-13,17-18,30,35H,14-16H2,1-2H3,(H,31,36)	IVFDDVKCCBDPQZ-UHFFFAOYSA-N	195601	GSK321::US11376246, Cpd ID GSK321::US11576906, Compound GSK321::US11311527, Cpd ID GSK321	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 4.6						25.00 C	Curated from the literature by BindingDB	10.1038/nchembio.1930	10.7270/Q2RR1X2G	26436839	aid1801986		Okoye-Okafor, UC; Bartholdy, B; Cartier, J; Gao, EN; Pietrak, B; Rendina, AR; Rominger, C; Quinn, C; Smallwood, A; Wiggall, KJ; Reif, AJ; Schmidt, SJ; Qi, H; Zhao, H; Joberty, G; Faelth-Savitski, M; Bantscheff, M; Drewes, G; Duraiswami, C; Brady, P; Groy, A; Narayanagari, SR; Antony-Debre, I; Mitchell, K; Wang, HR; Kao, YR; Christopeit, M; Carvajal, L; Barreyro, L; Paietta, E; Makishima, H; Will, B; Concha, N; Adams, ND; Schwartz, B; McCabe, MT; Maciejewski, J; Verma, A; Steidl, U	11/28/2015	10/7/2016	Albert Einstein College of Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=195601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=195601&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	59D	5DE1	91864709	318471187							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
348234	Cc1cccc(NC(=O)c2nn(Cc3c[nH]cn3)c3CCN(Cc23)C(=O)c2ccc[nH]2)c1	InChI=1S/C23H23N7O2/c1-15-4-2-5-16(10-15)27-22(31)21-18-13-29(23(32)19-6-3-8-25-19)9-7-20(18)30(28-21)12-17-11-24-14-26-17/h2-6,8,10-11,14,25H,7,9,12-13H2,1H3,(H,24,26)(H,27,31)	PYCSPHYSYJHUKG-UHFFFAOYSA-N	195602	GSK990	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10915						25.00 C	Curated from the literature by BindingDB	10.1038/nchembio.1930	10.7270/Q2RR1X2G	26436839	aid1801986		Okoye-Okafor, UC; Bartholdy, B; Cartier, J; Gao, EN; Pietrak, B; Rendina, AR; Rominger, C; Quinn, C; Smallwood, A; Wiggall, KJ; Reif, AJ; Schmidt, SJ; Qi, H; Zhao, H; Joberty, G; Faelth-Savitski, M; Bantscheff, M; Drewes, G; Duraiswami, C; Brady, P; Groy, A; Narayanagari, SR; Antony-Debre, I; Mitchell, K; Wang, HR; Kao, YR; Christopeit, M; Carvajal, L; Barreyro, L; Paietta, E; Makishima, H; Will, B; Concha, N; Adams, ND; Schwartz, B; McCabe, MT; Maciejewski, J; Verma, A; Steidl, U	11/28/2015	10/7/2016	Albert Einstein College of Medicine	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=195602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=195602&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			91864706	318471188							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
399568	Cc1ccccc1C(N(C(=O)Cn1cnc2ccccc12)c1cccc(F)c1)C(=O)NC1CCCC1	InChI=1S/C29H29FN4O2/c1-20-9-2-5-14-24(20)28(29(36)32-22-11-3-4-12-22)34(23-13-8-10-21(30)17-23)27(35)18-33-19-31-25-15-6-7-16-26(25)33/h2,5-10,13-17,19,22,28H,3-4,11-12,18H2,1H3,(H,32,36)	GZLNOSRHZLTDMT-UHFFFAOYSA-N	228658	rac-ML309	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 96							Curated from the literature by BindingDB	10.1074/jbc.M113.511030	10.7270/Q2513X35	24668804	aid1802831		Davis, MI; Gross, S; Shen, M; Straley, KS; Pragani, R; Lea, WA; Popovici-Muller, J; DeLaBarre, B; Artin, E; Thorne, N; Auld, DS; Li, Z; Dang, L; Boxer, MB; Simeonov, A	5/16/2014	5/22/2017	National Institutes of Health	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228658	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228658&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			56832449	336948180							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
399569	Cc1ccccc1[C@@H](N(C(=O)Cn1cnc2ccccc12)c1cccc(F)c1)C(=O)NC1CCCC1	InChI=1S/C29H29FN4O2/c1-20-9-2-5-14-24(20)28(29(36)32-22-11-3-4-12-22)34(23-13-8-10-21(30)17-23)27(35)18-33-19-31-25-15-6-7-16-26(25)33/h2,5-10,13-17,19,22,28H,3-4,11-12,18H2,1H3,(H,32,36)/t28-/m1/s1	GZLNOSRHZLTDMT-MUUNZHRXSA-N	228659	(+)-2-(2-(1H-Benzo[d]imidazol-1-yl)-N-(3-fluorophenyl)acetamido)-N-cyclopentyl-2-o-tolylacetamide::(+)-ML309	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 68							Curated from the literature by BindingDB	10.1074/jbc.M113.511030	10.7270/Q2513X35	24668804	aid1802831		Davis, MI; Gross, S; Shen, M; Straley, KS; Pragani, R; Lea, WA; Popovici-Muller, J; DeLaBarre, B; Artin, E; Thorne, N; Auld, DS; Li, Z; Dang, L; Boxer, MB; Simeonov, A	5/16/2014	5/22/2017	National Institutes of Health	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228659	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228659&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124604738	336948181							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
399570	Cc1ccccc1[C@H](N(C(=O)Cn1cnc2ccccc12)c1cccc(F)c1)C(=O)NC1CCCC1	InChI=1S/C29H29FN4O2/c1-20-9-2-5-14-24(20)28(29(36)32-22-11-3-4-12-22)34(23-13-8-10-21(30)17-23)27(35)18-33-19-31-25-15-6-7-16-26(25)33/h2,5-10,13-17,19,22,28H,3-4,11-12,18H2,1H3,(H,32,36)/t28-/m0/s1	GZLNOSRHZLTDMT-NDEPHWFRSA-N	228660	(-)-2-(2-(1H-Benzo[d]imidazol-1-yl)-N-(3-fluorophenyl)acetamido)-N-cyclopentyl-2-o-tolylacetamide::(-)-ML309	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29000							Curated from the literature by BindingDB	10.1074/jbc.M113.511030	10.7270/Q2513X35	24668804	aid1802831		Davis, MI; Gross, S; Shen, M; Straley, KS; Pragani, R; Lea, WA; Popovici-Muller, J; DeLaBarre, B; Artin, E; Thorne, N; Auld, DS; Li, Z; Dang, L; Boxer, MB; Simeonov, A	5/16/2014	5/22/2017	National Institutes of Health	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=228660	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=228660&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124604737	336948182							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471924	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)cc2)n1	InChI=1S/C24H28ClN5O4/c1-14(20-12-18(29-34-20)16-6-8-17(25)9-7-16)27-22-26-11-10-21(28-22)30-19(13-32-23(30)31)15(2)33-24(3,4)5/h6-12,14-15,19H,13H2,1-5H3,(H,26,27,28)/t14?,15-,19-/m1/s1	XTMBZOPPDDBHCY-PQYJZYHDSA-N	247479	US10112931, Example 1::US9434719, 1::US9688672, Example 1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1410					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247479	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247479&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415932	346542019							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471925	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1nc(NC(C)c2ncc(o2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C24H27ClFN5O4/c1-13(21-27-11-19(34-21)15-6-8-16(25)9-7-15)29-22-28-10-17(26)20(30-22)31-18(12-33-23(31)32)14(2)35-24(3,4)5/h6-11,13-14,18H,12H2,1-5H3,(H,28,29,30)/t13?,14-,18-/m1/s1	IHYYHUMBFQYNAV-JDPNFYKBSA-N	247480	US10112931, Example 2::US9434719, 2::US9688672, Example 2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 409					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247480	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247480&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416257	346542020							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471926	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)c(C)c2)n1	InChI=1S/C24H29ClN6O4/c1-13-11-16(7-8-17(13)25)20-29-21(35-30-20)14(2)27-22-26-10-9-19(28-22)31-18(12-33-23(31)32)15(3)34-24(4,5)6/h7-11,14-15,18H,12H2,1-6H3,(H,26,27,28)/t14?,15-,18-/m1/s1	RISGNMCTDXRSHM-QTLYGJNZSA-N	247481	US10112931, Example 4::US9434719, 4::US9688672, Example 4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1420					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247481	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247481&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414642	346542021							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471927	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(C)c2)n1	InChI=1S/C24H29FN6O4/c1-13-11-16(7-8-17(13)25)20-29-21(35-30-20)14(2)27-22-26-10-9-19(28-22)31-18(12-33-23(31)32)15(3)34-24(4,5)6/h7-11,14-15,18H,12H2,1-6H3,(H,26,27,28)/t14?,15-,18-/m1/s1	DCYDNMBZDQIZKQ-QTLYGJNZSA-N	247482	US10112931, Example 5::US9434719, 5::US9688672, Example 5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17800					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247482	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247482&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90413672	346542022							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471928	COc1cc(ccc1Cl)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)OC(C)(C)C	InChI=1S/C24H29ClN6O5/c1-13(21-29-20(30-36-21)15-7-8-16(25)18(11-15)33-6)27-22-26-10-9-19(28-22)31-17(12-34-23(31)32)14(2)35-24(3,4)5/h7-11,13-14,17H,12H2,1-6H3,(H,26,27,28)/t13?,14-,17-/m1/s1	WCSHCCIQCVRPAY-DTLKIFBZSA-N	247483	US10112931, Example 6::US9434719, 6::US9688672, Example 6	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1270					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247483	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247483&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414874	346542023							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471929	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)c(OC(F)(F)F)c2)n1	InChI=1S/C24H26ClF3N6O5/c1-12(20-32-19(33-39-20)14-6-7-15(25)17(10-14)38-24(26,27)28)30-21-29-9-8-18(31-21)34-16(11-36-22(34)35)13(2)37-23(3,4)5/h6-10,12-13,16H,11H2,1-5H3,(H,29,30,31)/t12?,13-,16-/m1/s1	RHYKSEFOCABYGI-LLQOJDTPSA-N	247484	US10112931, Example 7::US9434719, 7::US9688672, Example 7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2950					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247484	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247484&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414976	346542024							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471930	CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)OC(C)(C)C)c1nc(no1)-c1ccc2ccn(C)c2c1	InChI=1S/C26H31N7O4/c1-15(23-30-22(31-37-23)18-8-7-17-10-12-32(6)19(17)13-18)28-24-27-11-9-21(29-24)33-20(14-35-25(33)34)16(2)36-26(3,4)5/h7-13,15-16,20H,14H2,1-6H3,(H,27,28,29)/t15?,16-,20-/m1/s1	WBIDDDOZQAHNSX-KOIGGSBLSA-N	247485	US10112931, Example 8::US9434719, 8::US9688672, Example 8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2040					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247485	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247485&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90413782	346542025							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471931	CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)OC(C)(C)C)c1nc(no1)-c1cccc(c1)C(C)(C)C	InChI=1S/C27H36N6O4/c1-16(23-31-22(32-37-23)18-10-9-11-19(14-18)26(3,4)5)29-24-28-13-12-21(30-24)33-20(15-35-25(33)34)17(2)36-27(6,7)8/h9-14,16-17,20H,15H2,1-8H3,(H,28,29,30)/t16?,17-,20-/m1/s1	PSGDZLCFDHDDNW-HMEKMZBJSA-N	247486	US10112931, Example 9::US9434719, 9::US9688672, Example 9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2200					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247486	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247486&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414870	346542026							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471932	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(OC(F)(F)F)c2)n1	InChI=1S/C24H27F3N6O5/c1-13(20-31-19(32-38-20)15-7-6-8-16(11-15)37-24(25,26)27)29-21-28-10-9-18(30-21)33-17(12-35-22(33)34)14(2)36-23(3,4)5/h6-11,13-14,17H,12H2,1-5H3,(H,28,29,30)/t13?,14-,17-/m1/s1	RTLZLFVDXRHESM-DTLKIFBZSA-N	247487	US10112931, Example 10::US9434719, 10::US9688672, Example 10	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11700					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247487	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247487&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414564	346542027							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471933	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(OC(F)(F)F)c2)n1	InChI=1S/C24H26F4N6O5/c1-12(20-32-19(33-39-20)14-6-7-15(25)17(10-14)38-24(26,27)28)30-21-29-9-8-18(31-21)34-16(11-36-22(34)35)13(2)37-23(3,4)5/h6-10,12-13,16H,11H2,1-5H3,(H,29,30,31)/t12?,13-,16-/m1/s1	OQDLCSKYSGAKQO-LLQOJDTPSA-N	247488	US10112931, Example 11::US9434719, 11::US9688672, Example 11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3050					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247488	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247488&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414738	346542028							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471934	CC(C)c1ccc(cc1)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)OC(C)(C)C	InChI=1S/C26H34N6O4/c1-15(2)18-8-10-19(11-9-18)22-30-23(36-31-22)16(3)28-24-27-13-12-21(29-24)32-20(14-34-25(32)33)17(4)35-26(5,6)7/h8-13,15-17,20H,14H2,1-7H3,(H,27,28,29)/t16?,17-,20-/m1/s1	YJPDOSRZMMIZGK-HMEKMZBJSA-N	247489	US10112931, Example 12::US9434719, 12::US9688672, Example 12	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3270					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247489	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247489&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415538	346542029							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471935	CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)OC(C)(C)C)c1nc(no1)-c1cccc2n(C)c(C)cc12	InChI=1S/C27H33N7O4/c1-15-13-19-18(9-8-10-20(19)33(15)7)23-31-24(38-32-23)16(2)29-25-28-12-11-22(30-25)34-21(14-36-26(34)35)17(3)37-27(4,5)6/h8-13,16-17,21H,14H2,1-7H3,(H,28,29,30)/t16?,17-,21-/m1/s1	SXVMKUDXOWPKHS-PBTLETOKSA-N	247490	US10112931, Example 13::US9434719, 13::US9688672, Example 13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2190					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247490	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247490&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416719	346542030							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471936	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(C)c(o2)-c2ccc(Cl)cc2)n1	InChI=1S/C25H30ClN5O4/c1-14-21(17-7-9-18(26)10-8-17)34-22(28-14)15(2)29-23-27-12-11-20(30-23)31-19(13-33-24(31)32)16(3)35-25(4,5)6/h7-12,15-16,19H,13H2,1-6H3,(H,27,29,30)/t15?,16-,19-/m1/s1	ARZVPTRNEBWSAE-HFLHWUEFSA-N	247491	US10112931, Example 14::US9434719, 14::US9688672, Example 14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 405					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247491	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247491&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414415	346542031							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471937	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(c(C)s2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C25H29ClFN5O3S/c1-13(22-30-20(15(3)36-22)16-7-9-17(26)10-8-16)29-23-28-11-18(27)21(31-23)32-19(12-34-24(32)33)14(2)35-25(4,5)6/h7-11,13-14,19H,12H2,1-6H3,(H,28,29,31)/t13?,14-,19-/m1/s1	ODSXOIRGKNOKPX-SCDSDKBDSA-N	247492	US10112931, Example 26::US9434719, 26::US9688672, Example 26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3350					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247492	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247492&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414757	346542032							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471938	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(cs2)-c2ccc(Br)cc2)ncc1F	InChI=1S/C24H27BrFN5O3S/c1-13(21-29-18(12-35-21)15-6-8-16(25)9-7-15)28-22-27-10-17(26)20(30-22)31-19(11-33-23(31)32)14(2)34-24(3,4)5/h6-10,12-14,19H,11H2,1-5H3,(H,27,28,30)/t13?,14-,19-/m1/s1	ZQTGWCMOCMIHQG-SCDSDKBDSA-N	247493	US10112931, Example 27::US9434719, 27::US9688672, Example 27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2800					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247493	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247493&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416499	346542033							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471939	C[C@H](Nc1nccc(n1)N1C(COC1=O)C(C)C(F)(F)F)c1nc(no1)-c1ccc(Cl)cc1	InChI=1S/C20H18ClF3N6O3/c1-10(20(22,23)24)14-9-32-19(31)30(14)15-7-8-25-18(27-15)26-11(2)17-28-16(29-33-17)12-3-5-13(21)6-4-12/h3-8,10-11,14H,9H2,1-2H3,(H,25,26,27)/t10?,11-,14?/m0/s1	VWTGBFKWGWEASC-CVZZAPKMSA-N	247496	US10112931, Example 32::US9434719, 30::US9434719, 31::US9434719, 32::US9434719, 33::US9688672, Example 33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1090					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247496	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247496&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90417333	346542036							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471940	C[C@H](Nc1nccc(n1)N1C(COC1=O)C(C)C(F)(F)F)c1nc(no1)-c1ccc(Cl)cc1	InChI=1S/C20H18ClF3N6O3/c1-10(20(22,23)24)14-9-32-19(31)30(14)15-7-8-25-18(27-15)26-11(2)17-28-16(29-33-17)12-3-5-13(21)6-4-12/h3-8,10-11,14H,9H2,1-2H3,(H,25,26,27)/t10?,11-,14?/m0/s1	VWTGBFKWGWEASC-CVZZAPKMSA-N	247496	US10112931, Example 32::US9434719, 30::US9434719, 31::US9434719, 32::US9434719, 33::US9688672, Example 33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 627					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247496	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247496&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90417333	346542036							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471941	C[C@H](Nc1nccc(n1)N1C(COC1=O)C(C)C(F)(F)F)c1nc(no1)-c1ccc(Cl)cc1	InChI=1S/C20H18ClF3N6O3/c1-10(20(22,23)24)14-9-32-19(31)30(14)15-7-8-25-18(27-15)26-11(2)17-28-16(29-33-17)12-3-5-13(21)6-4-12/h3-8,10-11,14H,9H2,1-2H3,(H,25,26,27)/t10?,11-,14?/m0/s1	VWTGBFKWGWEASC-CVZZAPKMSA-N	247496	US10112931, Example 32::US9434719, 30::US9434719, 31::US9434719, 32::US9434719, 33::US9688672, Example 33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 16					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247496	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247496&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90417333	346542036							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471942	C[C@H](Nc1nccc(n1)N1C(COC1=O)C(C)C(F)(F)F)c1nc(no1)-c1ccc(Cl)cc1	InChI=1S/C20H18ClF3N6O3/c1-10(20(22,23)24)14-9-32-19(31)30(14)15-7-8-25-18(27-15)26-11(2)17-28-16(29-33-17)12-3-5-13(21)6-4-12/h3-8,10-11,14H,9H2,1-2H3,(H,25,26,27)/t10?,11-,14?/m0/s1	VWTGBFKWGWEASC-CVZZAPKMSA-N	247496	US10112931, Example 32::US9434719, 30::US9434719, 31::US9434719, 32::US9434719, 33::US9688672, Example 33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3660					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247496	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247496&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90417333	346542036							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471943	C[C@H](Nc1ncc(F)c(n1)N1C(COC1=O)C(C)C(F)(F)F)c1ccc(CO)c(F)c1	InChI=1S/C19H19F5N4O3/c1-9(19(22,23)24)15-8-31-18(30)28(15)16-14(21)6-25-17(27-16)26-10(2)11-3-4-12(7-29)13(20)5-11/h3-6,9-10,15,29H,7-8H2,1-2H3,(H,25,26,27)/t9?,10-,15?/m0/s1	KTKQDRRLZACGRQ-VOZQYIJBSA-N	247497	US10112931, Example 34::US9434719, 34::US9688672, Example 34	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 891					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247497	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247497&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415887	346542037							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471944	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cccc(Cl)c2Cl)n1	InChI=1S/C21H20Cl2N6O3/c1-11(19-25-8-13(9-26-19)14-4-3-5-15(22)18(14)23)27-20-24-7-6-17(28-20)29-16(12(2)30)10-32-21(29)31/h3-9,11-12,16,30H,10H2,1-2H3,(H,24,27,28)/t11?,12-,16-/m1/s1	VNCQUMNGFZCPNY-ZLXOECBPSA-N	247498	US10112931, Example 35::US9434719, 35::US9688672, Example 35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 33					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247498	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247498&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416870	346542038							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471945	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccccc2)n1	InChI=1S/C17H20N4O3/c1-11(13-6-4-3-5-7-13)19-16-18-9-8-15(20-16)21-14(12(2)22)10-24-17(21)23/h3-9,11-12,14,22H,10H2,1-2H3,(H,18,19,20)/t11-,12+,14+/m0/s1	KYSQKNCHILVPJH-OUCADQQQSA-N	247499	US10112931, Example 36::US9434719, 36::US9688672, Example 36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1410					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247499	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247499&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414391	346542039							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471946	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(OC(F)(F)F)c(Cl)c2)n1	InChI=1S/C20H18ClF3N6O5/c1-9(26-18-25-6-5-15(27-18)30-13(10(2)31)8-33-19(30)32)17-28-16(29-35-17)11-3-4-14(12(21)7-11)34-20(22,23)24/h3-7,9-10,13,31H,8H2,1-2H3,(H,25,26,27)/t9?,10-,13-/m1/s1	CHAWXCNNQSNUNC-SVLLLCHKSA-N	247500	US10112931, Example 38::US9434719, 37::US9434719, 38::US9688672, Example 38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2690					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247500	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247500&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451868	346542040							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471947	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(OC(F)(F)F)c(Cl)c2)n1	InChI=1S/C20H18ClF3N6O5/c1-9(26-18-25-6-5-15(27-18)30-13(10(2)31)8-33-19(30)32)17-28-16(29-35-17)11-3-4-14(12(21)7-11)34-20(22,23)24/h3-7,9-10,13,31H,8H2,1-2H3,(H,25,26,27)/t9?,10-,13-/m1/s1	CHAWXCNNQSNUNC-SVLLLCHKSA-N	247500	US10112931, Example 38::US9434719, 37::US9434719, 38::US9688672, Example 38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 55					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247500	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247500&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451868	346542040							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471948	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cc(F)ccc2C)n1	InChI=1S/C22H23FN6O3/c1-12-4-5-16(23)8-17(12)15-9-25-20(26-10-15)13(2)27-21-24-7-6-19(28-21)29-18(14(3)30)11-32-22(29)31/h4-10,13-14,18,30H,11H2,1-3H3,(H,24,27,28)/t13?,14-,18-/m1/s1	DBKNSMNYFOEUNI-JDPNFYKBSA-N	247501	US10112931, Example 39::US9434719, 39::US9688672, Example 39	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 202					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247501	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247501&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451869	346542041							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471949	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(cc2)C(F)(F)F)n1	InChI=1S/C22H21F3N6O3/c1-12(19-27-9-15(10-28-19)14-3-5-16(6-4-14)22(23,24)25)29-20-26-8-7-18(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,26,29,30)/t12?,13-,17-/m1/s1	CQYRFBORTMYXMZ-QQGYXAEISA-N	247502	US10112931, Example 40::US9434719, 40::US9688672, Example 40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 175					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247502	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247502&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451875	346542042							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471950	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(F)c(C)c2)n1	InChI=1S/C22H23FN6O3/c1-12-8-15(4-5-17(12)23)16-9-25-20(26-10-16)13(2)27-21-24-7-6-19(28-21)29-18(14(3)30)11-32-22(29)31/h4-10,13-14,18,30H,11H2,1-3H3,(H,24,27,28)/t13?,14-,18-/m1/s1	NSXQQANUCWJPOY-JDPNFYKBSA-N	247503	US10112931, Example 41::US9434719, 41::US9688672, Example 41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 253					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247503	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247503&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451876	346542043							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471951	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)C(C)(C)C)n1	InChI=1S/C19H26N6O3/c1-11(16-21-8-13(9-22-16)19(3,4)5)23-17-20-7-6-15(24-17)25-14(12(2)26)10-28-18(25)27/h6-9,11-12,14,26H,10H2,1-5H3,(H,20,23,24)/t11?,12-,14-/m1/s1	MQJZMGFPYLQLOL-JWCMVYSZSA-N	247504	US10112931, Example 42::US9434719, 42::US9688672, Example 42	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247504	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247504&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451870	346542044							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471952	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(Oc3ccccc3)cc2)n1	InChI=1S/C23H24N4O4/c1-15(17-8-10-19(11-9-17)31-18-6-4-3-5-7-18)25-22-24-13-12-21(26-22)27-20(16(2)28)14-30-23(27)29/h3-13,15-16,20,28H,14H2,1-2H3,(H,24,25,26)/t15-,16+,20+/m0/s1	ZVBJTYDCCGJGBT-RZQQEMMASA-N	247506	US10112931, Example 44::US9434719, 44::US9688672, Example 44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247506	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247506&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451877	346542046							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471953	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(Oc3ccc(F)cc3)cn2)n1	InChI=1S/C21H21FN6O4/c1-12(19-24-9-16(10-25-19)32-15-5-3-14(22)4-6-15)26-20-23-8-7-18(27-20)28-17(13(2)29)11-31-21(28)30/h3-10,12-13,17,29H,11H2,1-2H3,(H,23,26,27)/t12?,13-,17-/m1/s1	WRLFEODZWQFNLL-QQGYXAEISA-N	247507	US10112931, Example 45::US9434719, 45::US9688672, Example 45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1000					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247507	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247507&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451871	346542047							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471954	C[C@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)cc2)n1	InChI=1S/C19H19ClN6O4/c1-10(17-24-16(25-30-17)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)/t10?,11-,14+/m0/s1	HUKBLSVUBDBPMC-SAQKRVJRSA-N	247508	US10112931, Example 46::US9434719, 46::US9688672, Example 46	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2530					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247508	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247508&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451881	346542048							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471955	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(cn2)-c2cccc(c2)C(F)(F)F)n1	InChI=1S/C22H21F3N6O3/c1-12(16-9-28-17(10-27-16)14-4-3-5-15(8-14)22(23,24)25)29-20-26-7-6-19(30-20)31-18(13(2)32)11-34-21(31)33/h3-10,12-13,18,32H,11H2,1-2H3,(H,26,29,30)/t12-,13+,18+/m0/s1	AIHAGIQAZSVDEI-VEVIJQCQSA-N	247509	US10112931, Example 47::US9434719, 47::US9688672, Example 47	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 33					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247509	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247509&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268194	346542049							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471956	CC(O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(CN3CCN(C)C(C)(C)C3)c(F)c2)n1	InChI=1S/C25H35FN6O3/c1-16(28-23-27-9-8-22(29-23)32-21(17(2)33)14-35-24(32)34)18-6-7-19(20(26)12-18)13-31-11-10-30(5)25(3,4)15-31/h6-9,12,16-17,21,33H,10-11,13-15H2,1-5H3,(H,27,28,29)/t16-,17?,21+/m0/s1	BUVUVNWDUKCPLA-DSSITSQDSA-N	247510	US10112931, Example 48::US9434719, 48::US9688672, Example 48	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 463					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247510	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247510&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451873	346542050							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471957	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2ccc(F)c(C)c2)n1	InChI=1S/C23H24FN5O3/c1-13-10-16(4-6-18(13)24)17-5-7-19(26-11-17)14(2)27-22-25-9-8-21(28-22)29-20(15(3)30)12-32-23(29)31/h4-11,14-15,20,30H,12H2,1-3H3,(H,25,27,28)/t14-,15+,20+/m0/s1	XSHFXIHZJXTBDV-BXTJHSDWSA-N	247512	US10112931, Example 50::US9434719, 50::US9688672, Example 50	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 37					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247512	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247512&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268195	346542052							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471958	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2cccc(c2)C(F)(F)F)n1	InChI=1S/C23H22F3N5O3/c1-13(18-7-6-16(11-28-18)15-4-3-5-17(10-15)23(24,25)26)29-21-27-9-8-20(30-21)31-19(14(2)32)12-34-22(31)33/h3-11,13-14,19,32H,12H2,1-2H3,(H,27,29,30)/t13-,14+,19+/m0/s1	VMDPHSXVIWXENL-IQUTYRLHSA-N	247513	US10112931, Example 51::US9434719, 51::US9688672, Example 51	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 13					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247513	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247513&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268196	346542053							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471959	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(nc2)-c2ccc(F)c(C)c2)n1	InChI=1S/C23H24FN5O3/c1-13-10-16(4-6-18(13)24)19-7-5-17(11-26-19)14(2)27-22-25-9-8-21(28-22)29-20(15(3)30)12-32-23(29)31/h4-11,14-15,20,30H,12H2,1-3H3,(H,25,27,28)/t14-,15+,20+/m0/s1	GURKVSMLMZITAJ-BXTJHSDWSA-N	247514	US10112931, Example 52::US9434719, 52::US9688672, Example 52	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 210					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247514	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247514&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451884	346542054							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471960	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(nc2)-c2cccc(c2)C(F)(F)F)n1	InChI=1S/C23H22F3N5O3/c1-13(16-6-7-18(28-11-16)15-4-3-5-17(10-15)23(24,25)26)29-21-27-9-8-20(30-21)31-19(14(2)32)12-34-22(31)33/h3-11,13-14,19,32H,12H2,1-2H3,(H,27,29,30)/t13-,14+,19+/m0/s1	BKVBSKXUIQWZHL-IQUTYRLHSA-N	247515	US10112931, Example 53::US9434719, 53::US9688672, Example 53	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 46					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247515	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247515&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451890	346542055							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471961	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(cn2)-c2ccc(F)c(C)c2)n1	InChI=1S/C22H23FN6O3/c1-12-8-15(4-5-16(12)23)18-10-25-17(9-26-18)13(2)27-21-24-7-6-20(28-21)29-19(14(3)30)11-32-22(29)31/h4-10,13-14,19,30H,11H2,1-3H3,(H,24,27,28)/t13-,14+,19+/m0/s1	HPYOOSCRXHFCAE-IQUTYRLHSA-N	247516	US10112931, Example 54::US9434719, 54::US9688672, Example 54	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 116					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247516	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247516&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451893	346542056							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471962	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2ccnc(c2)C(F)(F)F)n1	InChI=1S/C22H21F3N6O3/c1-12(16-4-3-15(10-28-16)14-5-7-26-18(9-14)22(23,24)25)29-20-27-8-6-19(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,27,29,30)/t12-,13+,17+/m0/s1	RAPXSRRDJSAQDZ-OGHNNQOOSA-N	247517	US10112931, Example 55::US9434719, 55::US9688672, Example 55	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 279					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247517	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247517&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451880	346542057							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471963	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(nc2)-c2ccc(nc2)C(F)(F)F)n1	InChI=1S/C22H21F3N6O3/c1-12(14-3-5-16(27-9-14)15-4-6-18(28-10-15)22(23,24)25)29-20-26-8-7-19(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,26,29,30)/t12-,13+,17+/m0/s1	XFSCNSBPYIWAHD-OGHNNQOOSA-N	247518	US10112931, Example 56::US9434719, 56::US9688672, Example 56	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2920					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247518	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247518&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451887	346542058							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471964	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2ccc(nc2)C(F)(F)F)n1	InChI=1S/C22H21F3N6O3/c1-12(16-5-3-14(9-27-16)15-4-6-18(28-10-15)22(23,24)25)29-20-26-8-7-19(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,26,29,30)/t12-,13+,17+/m0/s1	XTXYFSXXMOXDER-OGHNNQOOSA-N	247519	US10112931, Example 57::US9434719, 57::US9688672, Example 57	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1270					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247519	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247519&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451894	346542059							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471965	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2cccc(n2)C(F)(F)F)n1	InChI=1S/C22H21F3N6O3/c1-12(15-7-6-14(10-27-15)16-4-3-5-18(29-16)22(23,24)25)28-20-26-9-8-19(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,26,28,30)/t12-,13+,17+/m0/s1	IUXAIJRAELDFJN-OGHNNQOOSA-N	247520	US10112931, Example 58::US9434719, 58::US9688672, Example 58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 27					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247520	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247520&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268388	346542060							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471966	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(C)c(cn2)-c2ccnc(c2)C(F)(F)F)n1	InChI=1S/C23H23F3N6O3/c1-12-8-17(29-10-16(12)15-4-6-27-19(9-15)23(24,25)26)13(2)30-21-28-7-5-20(31-21)32-18(14(3)33)11-35-22(32)34/h4-10,13-14,18,33H,11H2,1-3H3,(H,28,30,31)/t13-,14+,18+/m0/s1	ABQRTQHBTVLJNQ-PMUMKWKESA-N	247521	US10112931, Example 59::US9434719, 59::US9688672, Example 59	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 82					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247521	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247521&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268389	346542061							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471967	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cc2F)-c2ccnc(c2)C(F)(F)F)n1	InChI=1S/C22H20F4N6O3/c1-11(30-20-28-6-4-18(31-20)32-16(12(2)33)10-35-21(32)34)19-15(23)7-14(9-29-19)13-3-5-27-17(8-13)22(24,25)26/h3-9,11-12,16,33H,10H2,1-2H3,(H,28,30,31)/t11-,12+,16+/m0/s1	SYJIJRYLJLWTSU-HWWQOWPSSA-N	247522	US10112931, Example 60::US9434719, 60::US9688672, Example 60	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1100					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247522	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247522&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451888	346542062							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471968	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cc2C)-c2ccnc(c2)C(F)(F)F)n1	InChI=1S/C23H23F3N6O3/c1-12-8-16(15-4-6-27-18(9-15)23(24,25)26)10-29-20(12)13(2)30-21-28-7-5-19(31-21)32-17(14(3)33)11-35-22(32)34/h4-10,13-14,17,33H,11H2,1-3H3,(H,28,30,31)/t13-,14+,17+/m0/s1	SVDPLBBUVZHJFA-JJRVBVJISA-N	247523	US10112931, Example 61::US9434719, 61::US9688672, Example 61	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 313					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247523	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247523&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451882	346542063							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471969	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(c(C)n2)-c2ccnc(c2)C(F)(F)F)n1	InChI=1S/C23H23F3N6O3/c1-12-16(15-6-8-27-19(10-15)23(24,25)26)4-5-17(29-12)13(2)30-21-28-9-7-20(31-21)32-18(14(3)33)11-35-22(32)34/h4-10,13-14,18,33H,11H2,1-3H3,(H,28,30,31)/t13-,14+,18+/m0/s1	SDEKOZLCFXOLKN-PMUMKWKESA-N	247524	US10112931, Example 62::US9434719, 62::US9688672, Example 62	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 565					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247524	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247524&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451883	346542064							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471970	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2ccnc(c2)C(C)(C)C)n1	InChI=1S/C25H30N6O3/c1-15(19-7-6-18(13-28-19)17-8-10-26-21(12-17)25(3,4)5)29-23-27-11-9-22(30-23)31-20(16(2)32)14-34-24(31)33/h6-13,15-16,20,32H,14H2,1-5H3,(H,27,29,30)/t15-,16+,20+/m0/s1	ALPDIKWODPVZHR-RZQQEMMASA-N	247525	US10112931, Example 63::US9434719, 63::US9688672, Example 63	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247525	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247525&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451885	346542065							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471971	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2ccnc(c2)C(C)(C)C(F)(F)F)n1	InChI=1S/C25H27F3N6O3/c1-14(32-22-30-10-8-21(33-22)34-19(15(2)35)13-37-23(34)36)18-6-5-17(12-31-18)16-7-9-29-20(11-16)24(3,4)25(26,27)28/h5-12,14-15,19,35H,13H2,1-4H3,(H,30,32,33)/t14-,15+,19+/m0/s1	MUANIOOVSJGJDK-QMTMVMCOSA-N	247526	US10112931, Example 64::US9434719, 64::US9688672, Example 64	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247526	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247526&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451896	346542066							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471972	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2nc(cs2)-c2ccc(cc2)C#N)n1	InChI=1S/C21H20N6O3S/c1-12(19-25-16(11-31-19)15-5-3-14(9-22)4-6-15)24-20-23-8-7-18(26-20)27-17(13(2)28)10-30-21(27)29/h3-8,11-13,17,28H,10H2,1-2H3,(H,23,24,26)/t12-,13+,17+/m0/s1	XRDCVBTVNWZCPZ-OGHNNQOOSA-N	247527	US10112931, Example 65::US9434719, 65::US9688672, Example 65	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 797					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247527	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247527&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451895	346542067							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471973	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H20ClN5O4/c1-11(15-9-17(30-25-15)13-3-5-14(21)6-4-13)23-19-22-8-7-18(24-19)26-16(12(2)27)10-29-20(26)28/h3-9,11-12,16,27H,10H2,1-2H3,(H,22,23,24)/t11-,12+,16+/m0/s1	QNYFRTGGICDZAT-HWWQOWPSSA-N	247528	US10112931, Example 66::US9434719, 66::US9688672, Example 66	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 72					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247528	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247528&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268804	346542068							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471974	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@H](C)c2nc(cs2)-c2ccc(Cl)cc2Cl)n1	InChI=1S/C20H19Cl2N5O3S/c1-10(18-25-15(9-31-18)13-4-3-12(21)7-14(13)22)24-19-23-6-5-17(26-19)27-16(11(2)28)8-30-20(27)29/h3-7,9-11,16,28H,8H2,1-2H3,(H,23,24,26)/t10-,11-,16-/m1/s1	XOQPIDDDNUXVGQ-GLKRBJQHSA-N	247529	US10112931, Example 67::US9434719, 67::US9688672, Example 67	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1010					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247529	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247529&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451899	346542069							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471975	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2nc(cs2)-c2ccc(Cl)cc2Cl)n1	InChI=1S/C20H19Cl2N5O3S/c1-10(18-25-15(9-31-18)13-4-3-12(21)7-14(13)22)24-19-23-6-5-17(26-19)27-16(11(2)28)8-30-20(27)29/h3-7,9-11,16,28H,8H2,1-2H3,(H,23,24,26)/t10-,11+,16+/m0/s1	XOQPIDDDNUXVGQ-LYOVBCGYSA-N	247530	US10112931, Example 68::US9434719, 68::US9688672, Example 68	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 50					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247530	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247530&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451889	346542070							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471976	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@H](C)c2nc(cs2)-c2ccc(Br)cc2)n1	InChI=1S/C20H20BrN5O3S/c1-11(18-24-15(10-30-18)13-3-5-14(21)6-4-13)23-19-22-8-7-17(25-19)26-16(12(2)27)9-29-20(26)28/h3-8,10-12,16,27H,9H2,1-2H3,(H,22,23,25)/t11-,12-,16-/m1/s1	DIUJFHLCTQVPQN-XHBSWPGZSA-N	247531	US10112931, Example 69::US9434719, 69::US9688672, Example 69	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 639					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247531	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247531&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451900	346542071							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471977	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2nc(cs2)-c2ccc(Br)cc2)n1	InChI=1S/C20H20BrN5O3S/c1-11(18-24-15(10-30-18)13-3-5-14(21)6-4-13)23-19-22-8-7-17(25-19)26-16(12(2)27)9-29-20(26)28/h3-8,10-12,16,27H,9H2,1-2H3,(H,22,23,25)/t11-,12+,16+/m0/s1	DIUJFHLCTQVPQN-HWWQOWPSSA-N	247532	US10112931, Example 70::US9434719, 70::US9688672, Example 70	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 73					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247532	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247532&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451892	346542072							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471978	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@H](C)c2nc(cs2)-c2ccc(cc2)C#N)n1	InChI=1S/C21H20N6O3S/c1-12(19-25-16(11-31-19)15-5-3-14(9-22)4-6-15)24-20-23-8-7-18(26-20)27-17(13(2)28)10-30-21(27)29/h3-8,11-13,17,28H,10H2,1-2H3,(H,23,24,26)/t12-,13-,17-/m1/s1	XRDCVBTVNWZCPZ-PBFPGSCMSA-N	247533	US10112931, Example 71::US9434719, 71::US9688672, Example 71	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247533	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247533&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451897	346542073							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471979	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ccc(c(F)c2)-n2cc(C)cn2)n1	InChI=1S/C21H23FN6O3/c1-12-9-24-27(10-12)17-5-4-15(8-16(17)22)13(2)25-20-23-7-6-19(26-20)28-18(14(3)29)11-31-21(28)30/h4-10,13-14,18,29H,11H2,1-3H3,(H,23,25,26)/t13?,14-,18-/m1/s1	XDTMKVBEWIAKJH-JDPNFYKBSA-N	247535	US10112931, Example 73::US9434719, 73::US9688672, Example 73	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 181					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247535	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247535&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451902	346542075							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471980	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@H](C)c2cnc(cn2)-c2cccc(c2)C(F)(F)F)n1	InChI=1S/C22H21F3N6O3/c1-12(16-9-28-17(10-27-16)14-4-3-5-15(8-14)22(23,24)25)29-20-26-7-6-19(30-20)31-18(13(2)32)11-34-21(31)33/h3-10,12-13,18,32H,11H2,1-2H3,(H,26,29,30)/t12-,13-,18-/m1/s1	AIHAGIQAZSVDEI-SNUQEOBHSA-N	247539	US10112931, Example 78::US9434719, 78::US9688672, Example 78	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1630					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247539	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247539&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451909	346542079							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471981	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@H](C)c2cnc(cn2)-c2ccc(F)c(C)c2)n1	InChI=1S/C22H23FN6O3/c1-12-8-15(4-5-16(12)23)18-10-25-17(9-26-18)13(2)27-21-24-7-6-20(28-21)29-19(14(3)30)11-32-22(29)31/h4-10,13-14,19,30H,11H2,1-3H3,(H,24,27,28)/t13-,14-,19-/m1/s1	HPYOOSCRXHFCAE-PJIJBLCYSA-N	247540	US10112931, Example 79::US9434719, 79::US9688672, Example 79	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5310					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247540	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247540&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451904	346542080							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471982	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(F)c(c2)C(F)(F)F)n1	InChI=1S/C22H20F4N6O3/c1-11(30-20-27-6-5-18(31-20)32-17(12(2)33)10-35-21(32)34)19-28-8-14(9-29-19)13-3-4-16(23)15(7-13)22(24,25)26/h3-9,11-12,17,33H,10H2,1-2H3,(H,27,30,31)/t11?,12-,17-/m1/s1	HEWNCZLHQDDEPX-MYGFZHQOSA-N	174779	US10112931, Example 81::US9688672, Example 80	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 37					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174779	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174779&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451905	363892235							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471983	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(c2)C(F)(F)F)n1	InChI=1S/C22H20ClF3N6O3/c1-11(30-20-27-6-5-18(31-20)32-17(12(2)33)10-35-21(32)34)19-28-8-14(9-29-19)13-3-4-16(23)15(7-13)22(24,25)26/h3-9,11-12,17,33H,10H2,1-2H3,(H,27,30,31)/t11?,12-,17-/m1/s1	JZNHXMKFKNAHDQ-MYGFZHQOSA-N	174782	US10112931, Example 83::US9688672, Example 83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 19					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174782	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174782&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451906	363892236							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471984	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(c2)C(F)(F)F)n1	InChI=1S/C22H20ClF3N6O3/c1-11(30-20-27-6-5-18(31-20)32-17(12(2)33)10-35-21(32)34)19-28-8-14(9-29-19)13-3-4-16(23)15(7-13)22(24,25)26/h3-9,11-12,17,33H,10H2,1-2H3,(H,27,30,31)/t11?,12-,17-/m1/s1	JZNHXMKFKNAHDQ-MYGFZHQOSA-N	174782	US10112931, Example 83::US9688672, Example 83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 673					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174782	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174782&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451906	363892236							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471985	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(Cl)c2)n1	InChI=1S/C21H20Cl2N6O3/c1-11(19-25-8-14(9-26-19)13-3-4-15(22)16(23)7-13)27-20-24-6-5-18(28-20)29-17(12(2)30)10-32-21(29)31/h3-9,11-12,17,30H,10H2,1-2H3,(H,24,27,28)/t11?,12-,17-/m1/s1	FZJHBXOYJXRIDM-MYGFZHQOSA-N	174784	US10112931, Example 85::US9688672, Example 85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 48					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174784	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174784&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451911	363892237							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471986	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(Cl)c2)n1	InChI=1S/C21H20Cl2N6O3/c1-11(19-25-8-14(9-26-19)13-3-4-15(22)16(23)7-13)27-20-24-6-5-18(28-20)29-17(12(2)30)10-32-21(29)31/h3-9,11-12,17,30H,10H2,1-2H3,(H,24,27,28)/t11?,12-,17-/m1/s1	FZJHBXOYJXRIDM-MYGFZHQOSA-N	174784	US10112931, Example 85::US9688672, Example 85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1930					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174784	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174784&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451911	363892237							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471987	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cccc(c2)C(F)(F)F)n1	InChI=1S/C22H21F3N6O3/c1-12(19-27-9-15(10-28-19)14-4-3-5-16(8-14)22(23,24)25)29-20-26-7-6-18(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,26,29,30)/t12?,13-,17-/m1/s1	VTTHQMCVZHLBRX-QQGYXAEISA-N	174785	US10112931, Example 87::US9688672, Example 87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 41					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174785	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174785&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451872	363892238							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471988	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cccc(c2)C(F)(F)F)n1	InChI=1S/C22H21F3N6O3/c1-12(19-27-9-15(10-28-19)14-4-3-5-16(8-14)22(23,24)25)29-20-26-7-6-18(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,26,29,30)/t12?,13-,17-/m1/s1	VTTHQMCVZHLBRX-QQGYXAEISA-N	174785	US10112931, Example 87::US9688672, Example 87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 6690					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174785	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174785&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451872	363892238							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471989	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(C)c2)n1	InChI=1S/C22H23ClN6O3/c1-12-8-15(4-5-17(12)23)16-9-25-20(26-10-16)13(2)27-21-24-7-6-19(28-21)29-18(14(3)30)11-32-22(29)31/h4-10,13-14,18,30H,11H2,1-3H3,(H,24,27,28)/t13?,14-,18-/m1/s1	NGGVZAHPAFVHHU-JDPNFYKBSA-N	174786	US10112931, Example 89::US9688672, Example 89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 53					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174786	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174786&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451910	363892239							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471990	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(C)c2)n1	InChI=1S/C22H23ClN6O3/c1-12-8-15(4-5-17(12)23)16-9-25-20(26-10-16)13(2)27-21-24-7-6-19(28-21)29-18(14(3)30)11-32-22(29)31/h4-10,13-14,18,30H,11H2,1-3H3,(H,24,27,28)/t13?,14-,18-/m1/s1	NGGVZAHPAFVHHU-JDPNFYKBSA-N	174786	US10112931, Example 89::US9688672, Example 89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1360					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174786	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174786&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451910	363892239							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471991	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cc(Cl)cc(c2)C(F)(F)F)n1	InChI=1S/C22H20ClF3N6O3/c1-11(30-20-27-4-3-18(31-20)32-17(12(2)33)10-35-21(32)34)19-28-8-14(9-29-19)13-5-15(22(24,25)26)7-16(23)6-13/h3-9,11-12,17,33H,10H2,1-2H3,(H,27,30,31)/t11?,12-,17-/m1/s1	GBALYARIOVJFCR-MYGFZHQOSA-N	174788	US10112931, Example 91::US9688672, Example 91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 34					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174788	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174788&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451912	363892240							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471992	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cc(Cl)cc(c2)C(F)(F)F)n1	InChI=1S/C22H20ClF3N6O3/c1-11(30-20-27-4-3-18(31-20)32-17(12(2)33)10-35-21(32)34)19-28-8-14(9-29-19)13-5-15(22(24,25)26)7-16(23)6-13/h3-9,11-12,17,33H,10H2,1-2H3,(H,27,30,31)/t11?,12-,17-/m1/s1	GBALYARIOVJFCR-MYGFZHQOSA-N	174788	US10112931, Example 91::US9688672, Example 91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 274					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174788	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174788&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451912	363892240							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471993	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)cc2)n1	InChI=1S/C19H19ClN6O4/c1-10(17-24-16(25-30-17)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)/t10?,11-,14-/m1/s1	HUKBLSVUBDBPMC-MDLDFJCZSA-N	174789	US10112931, Example 93::US9688672, Example 93	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5825					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174789	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174789&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451914	363892241							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471994	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)cc2)n1	InChI=1S/C19H19ClN6O4/c1-10(17-24-16(25-30-17)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)/t10?,11-,14-/m1/s1	HUKBLSVUBDBPMC-MDLDFJCZSA-N	174789	US10112931, Example 93::US9688672, Example 93	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 213					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174789	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174789&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451914	363892241							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471995	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccc(F)cc2)n1	InChI=1S/C19H19FN6O4/c1-10(16-24-25-17(30-16)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)/t10?,11-,14-/m1/s1	PAHVPGBAKFTYHR-MDLDFJCZSA-N	174791	US10112931, Example 95::US9688672, Example 95	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14900					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174791	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174791&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451913	363892242							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471996	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccc(F)cc2)n1	InChI=1S/C19H19FN6O4/c1-10(16-24-25-17(30-16)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)/t10?,11-,14-/m1/s1	PAHVPGBAKFTYHR-MDLDFJCZSA-N	174791	US10112931, Example 95::US9688672, Example 95	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1530					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174791	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174791&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451913	363892242							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471997	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(CCOc3ccccc3)no2)n1	InChI=1S/C21H24N6O5/c1-13(19-24-17(26-32-19)9-11-30-15-6-4-3-5-7-15)23-20-22-10-8-18(25-20)27-16(14(2)28)12-31-21(27)29/h3-8,10,13-14,16,28H,9,11-12H2,1-2H3,(H,22,23,25)/t13?,14-,16-/m1/s1	DIDRDLJTUVCPRG-IGLHTZBQSA-N	247549	US10112931, Example 97::US9434719, 97::US9688672, Example 97	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 972					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247549	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247549&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451916	346542089							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471998	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccc(C)cc2)n1	InChI=1S/C20H22N6O4/c1-11-4-6-14(7-5-11)18-25-24-17(30-18)12(2)22-19-21-9-8-16(23-19)26-15(13(3)27)10-29-20(26)28/h4-9,12-13,15,27H,10H2,1-3H3,(H,21,22,23)/t12?,13-,15-/m1/s1	FXPWKPAUTKSPOQ-JYRZLJSNSA-N	247550	US10112931, Example 99::US9434719, 99::US9688672, Example 99	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 351					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247550	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247550&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451915	346542090							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
471999	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccc(C)cc2)n1	InChI=1S/C20H22N6O4/c1-11-4-6-14(7-5-11)18-25-24-17(30-18)12(2)22-19-21-9-8-16(23-19)26-15(13(3)27)10-29-20(26)28/h4-9,12-13,15,27H,10H2,1-3H3,(H,21,22,23)/t12?,13-,15-/m1/s1	FXPWKPAUTKSPOQ-JYRZLJSNSA-N	247550	US10112931, Example 99::US9434719, 99::US9688672, Example 99	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 9790					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247550	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247550&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451915	346542090							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472000	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2cccc(C)c2)n1	InChI=1S/C20H22N6O4/c1-11-5-4-6-14(9-11)18-25-24-17(30-18)12(2)22-19-21-8-7-16(23-19)26-15(13(3)27)10-29-20(26)28/h4-9,12-13,15,27H,10H2,1-3H3,(H,21,22,23)/t12?,13-,15-/m1/s1	PRKYEWVCKHGIFQ-JYRZLJSNSA-N	247553	US10112931, Example 105::US9434719, 105::US9688672, Example 105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247553	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247553&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451922	346542093							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472001	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2cccc(C)c2)n1	InChI=1S/C20H22N6O4/c1-11-5-4-6-14(9-11)18-25-24-17(30-18)12(2)22-19-21-8-7-16(23-19)26-15(13(3)27)10-29-20(26)28/h4-9,12-13,15,27H,10H2,1-3H3,(H,21,22,23)/t12?,13-,15-/m1/s1	PRKYEWVCKHGIFQ-JYRZLJSNSA-N	247553	US10112931, Example 105::US9434719, 105::US9688672, Example 105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2430					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247553	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247553&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451922	346542093							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472002	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccccc2C)n1	InChI=1S/C20H22N6O4/c1-11-6-4-5-7-14(11)18-25-24-17(30-18)12(2)22-19-21-9-8-16(23-19)26-15(13(3)27)10-29-20(26)28/h4-9,12-13,15,27H,10H2,1-3H3,(H,21,22,23)/t12?,13-,15-/m1/s1	CCYGBRQOYRJHRW-JYRZLJSNSA-N	247554	US10112931, Example 107::US9434719, 107::US9688672, Example 107	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247554	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247554&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451926	346542094							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472003	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccccc2C)n1	InChI=1S/C20H22N6O4/c1-11-6-4-5-7-14(11)18-25-24-17(30-18)12(2)22-19-21-9-8-16(23-19)26-15(13(3)27)10-29-20(26)28/h4-9,12-13,15,27H,10H2,1-3H3,(H,21,22,23)/t12?,13-,15-/m1/s1	CCYGBRQOYRJHRW-JYRZLJSNSA-N	247554	US10112931, Example 107::US9434719, 107::US9688672, Example 107	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1220					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247554	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247554&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451926	346542094							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472004	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(c(C)s2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H22ClN5O3S/c1-11(19-26-18(13(3)31-19)14-4-6-15(22)7-5-14)24-20-23-9-8-17(25-20)27-16(12(2)28)10-30-21(27)29/h4-9,11-12,16,28H,10H2,1-3H3,(H,23,24,25)/t11?,12-,16-/m1/s1	AIVKCQOVERPJLV-ZLXOECBPSA-N	247555	US10112931, Example 109::US9434719, 109::US9688672, Example 109	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11700					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247555	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247555&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451927	346542095							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472005	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(c(C)s2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H22ClN5O3S/c1-11(19-26-18(13(3)31-19)14-4-6-15(22)7-5-14)24-20-23-9-8-17(25-20)27-16(12(2)28)10-30-21(27)29/h4-9,11-12,16,28H,10H2,1-3H3,(H,23,24,25)/t11?,12-,16-/m1/s1	AIVKCQOVERPJLV-ZLXOECBPSA-N	247555	US10112931, Example 109::US9434719, 109::US9688672, Example 109	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 121					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247555	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247555&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451927	346542095							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472006	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2cccc(F)c2)n1	InChI=1S/C19H19FN6O4/c1-10(16-24-25-17(30-16)12-4-3-5-13(20)8-12)22-18-21-7-6-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)/t10?,11-,14-/m1/s1	ILNTZEINCNMYCW-MDLDFJCZSA-N	247556	US10112931, Example 111::US9434719, 111::US9688672, Example 111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247556	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247556&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451918	346542096							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472007	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2cccc(F)c2)n1	InChI=1S/C19H19FN6O4/c1-10(16-24-25-17(30-16)12-4-3-5-13(20)8-12)22-18-21-7-6-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)/t10?,11-,14-/m1/s1	ILNTZEINCNMYCW-MDLDFJCZSA-N	247556	US10112931, Example 111::US9434719, 111::US9688672, Example 111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2780					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247556	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247556&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451918	346542096							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472008	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2cccnc2)n1	InChI=1S/C18H19N7O4/c1-10(15-23-24-16(29-15)12-4-3-6-19-8-12)21-17-20-7-5-14(22-17)25-13(11(2)26)9-28-18(25)27/h3-8,10-11,13,26H,9H2,1-2H3,(H,20,21,22)/t10?,11-,13-/m1/s1	QBZCMJWQPGHZCV-LIXJUXSLSA-N	247557	US10112931, Example 113::US9434719, 113::US9688672, Example 113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247557	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247557&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451930	346542097							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472009	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2cccnc2)n1	InChI=1S/C18H19N7O4/c1-10(15-23-24-16(29-15)12-4-3-6-19-8-12)21-17-20-7-5-14(22-17)25-13(11(2)26)9-28-18(25)27/h3-8,10-11,13,26H,9H2,1-2H3,(H,20,21,22)/t10?,11-,13-/m1/s1	QBZCMJWQPGHZCV-LIXJUXSLSA-N	247557	US10112931, Example 113::US9434719, 113::US9688672, Example 113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247557	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247557&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451930	346542097							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472010	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2noc(Cc3ccccc3)n2)n1	InChI=1S/C20H22N6O4/c1-12(18-24-17(30-25-18)10-14-6-4-3-5-7-14)22-19-21-9-8-16(23-19)26-15(13(2)27)11-29-20(26)28/h3-9,12-13,15,27H,10-11H2,1-2H3,(H,21,22,23)/t12?,13-,15-/m1/s1	NBOLFMVBIZMHBG-JYRZLJSNSA-N	247558	US10112931, Example 115::US9434719, 115::US9688672, Example 115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247558	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247558&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451934	346542098							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472011	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2noc(Cc3ccccc3)n2)n1	InChI=1S/C20H22N6O4/c1-12(18-24-17(30-25-18)10-14-6-4-3-5-7-14)22-19-21-9-8-16(23-19)26-15(13(2)27)11-29-20(26)28/h3-9,12-13,15,27H,10-11H2,1-2H3,(H,21,22,23)/t12?,13-,15-/m1/s1	NBOLFMVBIZMHBG-JYRZLJSNSA-N	247558	US10112931, Example 115::US9434719, 115::US9688672, Example 115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7890					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247558	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247558&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451934	346542098							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472012	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2noc(Cc3ccccc3)n2)ncc1F	InChI=1S/C20H21FN6O4/c1-11(17-24-16(31-26-17)8-13-6-4-3-5-7-13)23-19-22-9-14(21)18(25-19)27-15(12(2)28)10-30-20(27)29/h3-7,9,11-12,15,28H,8,10H2,1-2H3,(H,22,23,25)/t11?,12-,15-/m1/s1	RUTLACTVCZTWSF-AADWAWOOSA-N	247559	US10112931, Example 117::US9434719, 117::US9688672, Example 117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247559	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247559&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451932	346542099							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472013	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2noc(Cc3ccccc3)n2)ncc1F	InChI=1S/C20H21FN6O4/c1-11(17-24-16(31-26-17)8-13-6-4-3-5-7-13)23-19-22-9-14(21)18(25-19)27-15(12(2)28)10-30-20(27)29/h3-7,9,11-12,15,28H,8,10H2,1-2H3,(H,22,23,25)/t11?,12-,15-/m1/s1	RUTLACTVCZTWSF-AADWAWOOSA-N	247559	US10112931, Example 117::US9434719, 117::US9688672, Example 117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1410					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247559	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247559&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451932	346542099							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472014	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Br)cc2)n1	InChI=1S/C19H19BrN6O4/c1-10(17-24-16(25-30-17)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)/t10?,11-,14-/m1/s1	QJFYKXSETKYZJA-MDLDFJCZSA-N	247560	US10112931, Example 119::US9434719, 119::US9688672, Example 119	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3560					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247560	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247560&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451919	346542100							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472015	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Br)cc2)n1	InChI=1S/C19H19BrN6O4/c1-10(17-24-16(25-30-17)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)/t10?,11-,14-/m1/s1	QJFYKXSETKYZJA-MDLDFJCZSA-N	247560	US10112931, Example 119::US9434719, 119::US9688672, Example 119	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 45					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247560	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247560&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451919	346542100							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472016	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(C)c(F)c2)n1	InChI=1S/C20H21FN6O4/c1-10-4-5-13(8-14(10)21)17-25-18(31-26-17)11(2)23-19-22-7-6-16(24-19)27-15(12(3)28)9-30-20(27)29/h4-8,11-12,15,28H,9H2,1-3H3,(H,22,23,24)/t11?,12-,15-/m1/s1	CQNIUVQCNAZHDZ-AADWAWOOSA-N	247561	US10112931, Example 121::US9434719, 121::US9688672, Example 121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 182					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247561	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247561&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451921	346542101							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472017	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(C)c(F)c2)ncc1F	InChI=1S/C20H20F2N6O4/c1-9-4-5-12(6-13(9)21)16-25-18(32-27-16)10(2)24-19-23-7-14(22)17(26-19)28-15(11(3)29)8-31-20(28)30/h4-7,10-11,15,29H,8H2,1-3H3,(H,23,24,26)/t10?,11-,15-/m1/s1	SNSAPFWSGVJLEA-HUFXEGEASA-N	247562	US10112931, Example 123::US9434719, 123::US9688672, Example 123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 370					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247562	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247562&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451928	346542102							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472018	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(C)c(F)c2)ncc1F	InChI=1S/C20H20F2N6O4/c1-9-4-5-12(6-13(9)21)16-25-18(32-27-16)10(2)24-19-23-7-14(22)17(26-19)28-15(11(3)29)8-31-20(28)30/h4-7,10-11,15,29H,8H2,1-3H3,(H,23,24,26)/t10?,11-,15-/m1/s1	SNSAPFWSGVJLEA-HUFXEGEASA-N	247562	US10112931, Example 123::US9434719, 123::US9688672, Example 123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 30					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247562	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247562&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451928	346542102							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472019	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(F)c2)n1	InChI=1S/C19H18F2N6O4/c1-9(17-25-16(26-31-17)11-3-4-12(20)13(21)7-11)23-18-22-6-5-15(24-18)27-14(10(2)28)8-30-19(27)29/h3-7,9-10,14,28H,8H2,1-2H3,(H,22,23,24)/t9?,10-,14-/m1/s1	DNFOGQQVCPUNRQ-WUMONGPASA-N	247563	US10112931, Example 125::US9434719, 125::US9688672, Example 125	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18800					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247563	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247563&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451923	346542103							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472020	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(F)c2)n1	InChI=1S/C19H18F2N6O4/c1-9(17-25-16(26-31-17)11-3-4-12(20)13(21)7-11)23-18-22-6-5-15(24-18)27-14(10(2)28)8-30-19(27)29/h3-7,9-10,14,28H,8H2,1-2H3,(H,22,23,24)/t9?,10-,14-/m1/s1	DNFOGQQVCPUNRQ-WUMONGPASA-N	247563	US10112931, Example 125::US9434719, 125::US9688672, Example 125	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 158					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247563	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247563&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451923	346542103							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472021	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)c(Cl)c2)n1	InChI=1S/C20H19Cl2N5O4/c1-10(17-8-15(26-31-17)12-3-4-13(21)14(22)7-12)24-19-23-6-5-18(25-19)27-16(11(2)28)9-30-20(27)29/h3-8,10-11,16,28H,9H2,1-2H3,(H,23,24,25)/t10?,11-,16-/m1/s1	UGMWZDGPRLEDLZ-MKYLOTPESA-N	247564	US10112931, Example 127::US9434719, 127::US9688672, Example 127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 274					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247564	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247564&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451933	346542104							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472022	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)c(Cl)c2)n1	InChI=1S/C20H19Cl2N5O4/c1-10(17-8-15(26-31-17)12-3-4-13(21)14(22)7-12)24-19-23-6-5-18(25-19)27-16(11(2)28)9-30-20(27)29/h3-8,10-11,16,28H,9H2,1-2H3,(H,23,24,25)/t10?,11-,16-/m1/s1	UGMWZDGPRLEDLZ-MKYLOTPESA-N	247564	US10112931, Example 127::US9434719, 127::US9688672, Example 127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 32					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247564	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247564&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451933	346542104							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472023	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)cc2Cl)n1	InChI=1S/C20H19Cl2N5O4/c1-10(17-8-15(26-31-17)13-4-3-12(21)7-14(13)22)24-19-23-6-5-18(25-19)27-16(11(2)28)9-30-20(27)29/h3-8,10-11,16,28H,9H2,1-2H3,(H,23,24,25)/t10?,11-,16-/m1/s1	FIJAWJNDDPPIQM-MKYLOTPESA-N	247565	US10112931, Example 129::US9434719, 128::US9434719, 129::US9688672, Example 129	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 50					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247565	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247565&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451935	346542105							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472024	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)cc2Cl)n1	InChI=1S/C20H19Cl2N5O4/c1-10(17-8-15(26-31-17)13-4-3-12(21)7-14(13)22)24-19-23-6-5-18(25-19)27-16(11(2)28)9-30-20(27)29/h3-8,10-11,16,28H,9H2,1-2H3,(H,23,24,25)/t10?,11-,16-/m1/s1	FIJAWJNDDPPIQM-MKYLOTPESA-N	247565	US10112931, Example 129::US9434719, 128::US9434719, 129::US9688672, Example 129	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1800					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247565	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247565&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451935	346542105							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472025	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(F)c(F)c2)ncc1F	InChI=1S/C19H17F3N6O4/c1-8(17-25-15(27-32-17)10-3-4-11(20)12(21)5-10)24-18-23-6-13(22)16(26-18)28-14(9(2)29)7-31-19(28)30/h3-6,8-9,14,29H,7H2,1-2H3,(H,23,24,26)/t8?,9-,14-/m1/s1	CZKHIFLFSUFAEU-MNAQOFIPSA-N	247566	US10112931, Example 131::US9434719, 131::US9688672, Example 131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1510					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247566	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247566&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451924	346542106							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472026	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(F)c(F)c2)ncc1F	InChI=1S/C19H17F3N6O4/c1-8(17-25-15(27-32-17)10-3-4-11(20)12(21)5-10)24-18-23-6-13(22)16(26-18)28-14(9(2)29)7-31-19(28)30/h3-6,8-9,14,29H,7H2,1-2H3,(H,23,24,26)/t8?,9-,14-/m1/s1	CZKHIFLFSUFAEU-MNAQOFIPSA-N	247566	US10112931, Example 131::US9434719, 131::US9688672, Example 131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 56					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247566	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247566&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451924	346542106							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472027	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2cc(no2)-c2ccc(Cl)c(Cl)c2)ncc1F	InChI=1S/C20H18Cl2FN5O4/c1-9(17-6-15(27-32-17)11-3-4-12(21)13(22)5-11)25-19-24-7-14(23)18(26-19)28-16(10(2)29)8-31-20(28)30/h3-7,9-10,16,29H,8H2,1-2H3,(H,24,25,26)/t9?,10-,16-/m1/s1	GBGXXLPKYDLGDN-MVHXDWSJSA-N	247567	US10112931, Example 133::US9434719, 133::US9688672, Example 133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 956					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247567	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247567&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451925	346542107							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472028	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2cc(no2)-c2ccc(Cl)c(Cl)c2)ncc1F	InChI=1S/C20H18Cl2FN5O4/c1-9(17-6-15(27-32-17)11-3-4-12(21)13(22)5-11)25-19-24-7-14(23)18(26-19)28-16(10(2)29)8-31-20(28)30/h3-7,9-10,16,29H,8H2,1-2H3,(H,24,25,26)/t9?,10-,16-/m1/s1	GBGXXLPKYDLGDN-MVHXDWSJSA-N	247567	US10112931, Example 133::US9434719, 133::US9688672, Example 133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7.00					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247567	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247567&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451925	346542107							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472029	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2cc(no2)-c2ccc(Cl)cc2Cl)ncc1F	InChI=1S/C20H18Cl2FN5O4/c1-9(17-6-15(27-32-17)12-4-3-11(21)5-13(12)22)25-19-24-7-14(23)18(26-19)28-16(10(2)29)8-31-20(28)30/h3-7,9-10,16,29H,8H2,1-2H3,(H,24,25,26)/t9?,10-,16-/m1/s1	HJSGEOWEKHAQKS-MVHXDWSJSA-N	247568	US10112931, Example 135::US9434719, 135::US9688672, Example 135	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1460					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247568	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247568&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451929	346542108							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472030	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2cc(no2)-c2ccc(Cl)cc2Cl)ncc1F	InChI=1S/C20H18Cl2FN5O4/c1-9(17-6-15(27-32-17)12-4-3-11(21)5-13(12)22)25-19-24-7-14(23)18(26-19)28-16(10(2)29)8-31-20(28)30/h3-7,9-10,16,29H,8H2,1-2H3,(H,24,25,26)/t9?,10-,16-/m1/s1	HJSGEOWEKHAQKS-MVHXDWSJSA-N	247568	US10112931, Example 135::US9434719, 135::US9688672, Example 135	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247568	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247568&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451929	346542108							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472031	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(cs2)-c2ccc(F)c(Cl)c2)n1	InChI=1S/C20H19ClFN5O3S/c1-10(18-25-15(9-31-18)12-3-4-14(22)13(21)7-12)24-19-23-6-5-17(26-19)27-16(11(2)28)8-30-20(27)29/h3-7,9-11,16,28H,8H2,1-2H3,(H,23,24,26)/t10?,11-,16-/m1/s1	PFONREBTTNAHEI-MKYLOTPESA-N	247569	US10112931, Example 137::US9434719, 137::US9688672, Example 137	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11300					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247569	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247569&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451931	346542109							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472032	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(cs2)-c2ccc(F)c(Cl)c2)n1	InChI=1S/C20H19ClFN5O3S/c1-10(18-25-15(9-31-18)12-3-4-14(22)13(21)7-12)24-19-23-6-5-17(26-19)27-16(11(2)28)8-30-20(27)29/h3-7,9-11,16,28H,8H2,1-2H3,(H,23,24,26)/t10?,11-,16-/m1/s1	PFONREBTTNAHEI-MKYLOTPESA-N	247569	US10112931, Example 137::US9434719, 137::US9688672, Example 137	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1190					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247569	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247569&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451931	346542109							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472033	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2ncc(cn2)-c2cccc(c2)C(F)(F)F)ncc1F	InChI=1S/C22H20F4N6O3/c1-11(18-27-7-14(8-28-18)13-4-3-5-15(6-13)22(24,25)26)30-20-29-9-16(23)19(31-20)32-17(12(2)33)10-35-21(32)34/h3-9,11-12,17,33H,10H2,1-2H3,(H,29,30,31)/t11?,12-,17-/m1/s1	DQWHZZJMALNHIB-MYGFZHQOSA-N	247570	US10112931, Example 139::US9434719, 139::US9688672, Example 139	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247570	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247570&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451936	346542110							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472034	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2ncc(cn2)-c2cccc(c2)C(F)(F)F)ncc1F	InChI=1S/C22H20F4N6O3/c1-11(18-27-7-14(8-28-18)13-4-3-5-15(6-13)22(24,25)26)30-20-29-9-16(23)19(31-20)32-17(12(2)33)10-35-21(32)34/h3-9,11-12,17,33H,10H2,1-2H3,(H,29,30,31)/t11?,12-,17-/m1/s1	DQWHZZJMALNHIB-MYGFZHQOSA-N	247570	US10112931, Example 139::US9434719, 139::US9688672, Example 139	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 260					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247570	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247570&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451936	346542110							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472035	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cnc(s2)-c2ccccc2)n1	InChI=1S/C20H21N5O3S/c1-12(16-10-22-18(29-16)14-6-4-3-5-7-14)23-19-21-9-8-17(24-19)25-15(13(2)26)11-28-20(25)27/h3-10,12-13,15,26H,11H2,1-2H3,(H,21,23,24)/t12?,13-,15-/m1/s1	JBIBAWVBYNZUKK-JYRZLJSNSA-N	247571	US10112931, Example 141::US9434719, 141::US9688672, Example 141	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10600					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247571	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247571&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451943	346542111							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472036	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cnc(s2)-c2ccccc2)n1	InChI=1S/C20H21N5O3S/c1-12(16-10-22-18(29-16)14-6-4-3-5-7-14)23-19-21-9-8-17(24-19)25-15(13(2)26)11-28-20(25)27/h3-10,12-13,15,26H,11H2,1-2H3,(H,21,23,24)/t12?,13-,15-/m1/s1	JBIBAWVBYNZUKK-JYRZLJSNSA-N	247571	US10112931, Example 141::US9434719, 141::US9688672, Example 141	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 660					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247571	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247571&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451943	346542111							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472037	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(Cl)c2)n1	InChI=1S/C19H19ClN6O4/c1-10(17-24-16(25-30-17)12-4-3-5-13(20)8-12)22-18-21-7-6-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)/t10?,11-,14-/m1/s1	VDEXLVZLFHDDEG-MDLDFJCZSA-N	247572	US10112931, Example 143::US9434719, 143::US9688672, Example 143	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247572	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247572&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451937	346542112							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472038	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(Cl)c2)n1	InChI=1S/C19H19ClN6O4/c1-10(17-24-16(25-30-17)12-4-3-5-13(20)8-12)22-18-21-7-6-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)/t10?,11-,14-/m1/s1	VDEXLVZLFHDDEG-MDLDFJCZSA-N	247572	US10112931, Example 143::US9434719, 143::US9688672, Example 143	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 756					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247572	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247572&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451937	346542112							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472039	CC(C)c1ccc(cc1)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O	InChI=1S/C22H26N6O4/c1-12(2)15-5-7-16(8-6-15)19-26-20(32-27-19)13(3)24-21-23-10-9-18(25-21)28-17(14(4)29)11-31-22(28)30/h5-10,12-14,17,29H,11H2,1-4H3,(H,23,24,25)/t13?,14-,17-/m1/s1	WTHXIYPSRHQDSX-DTLKIFBZSA-N	247573	US10112931, Example 145::US9434719, 145::US9688672, Example 145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1670					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247573	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247573&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451938	346542113							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472040	CC(C)c1ccc(cc1)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O	InChI=1S/C22H26N6O4/c1-12(2)15-5-7-16(8-6-15)19-26-20(32-27-19)13(3)24-21-23-10-9-18(25-21)28-17(14(4)29)11-31-22(28)30/h5-10,12-14,17,29H,11H2,1-4H3,(H,23,24,25)/t13?,14-,17-/m1/s1	WTHXIYPSRHQDSX-DTLKIFBZSA-N	247573	US10112931, Example 145::US9434719, 145::US9688672, Example 145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247573	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247573&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451938	346542113							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472041	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(C)c2)n1	InChI=1S/C20H21FN6O4/c1-10-8-13(4-5-14(10)21)17-25-18(31-26-17)11(2)23-19-22-7-6-16(24-19)27-15(12(3)28)9-30-20(27)29/h4-8,11-12,15,28H,9H2,1-3H3,(H,22,23,24)/t11?,12-,15-/m1/s1	DBIUWIKBQRDZEO-AADWAWOOSA-N	247575	US10112931, Example 149::US9434719, 149::US9688672, Example 149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 9590					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247575	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247575&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451946	346542115							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472042	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(C)c2)n1	InChI=1S/C20H21FN6O4/c1-10-8-13(4-5-14(10)21)17-25-18(31-26-17)11(2)23-19-22-7-6-16(24-19)27-15(12(3)28)9-30-20(27)29/h4-8,11-12,15,28H,9H2,1-3H3,(H,22,23,24)/t11?,12-,15-/m1/s1	DBIUWIKBQRDZEO-AADWAWOOSA-N	247575	US10112931, Example 149::US9434719, 149::US9688672, Example 149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 194					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247575	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247575&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451946	346542115							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472043	CCc1ccc(cc1)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O	InChI=1S/C21H24N6O4/c1-4-14-5-7-15(8-6-14)18-25-19(31-26-18)12(2)23-20-22-10-9-17(24-20)27-16(13(3)28)11-30-21(27)29/h5-10,12-13,16,28H,4,11H2,1-3H3,(H,22,23,24)/t12?,13-,16-/m1/s1	WWQSBBFDNJQGEO-LLQOJDTPSA-N	247587	US10112931, Example 173::US9434719, 173::US9688672, Example 173	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 43					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247587	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247587&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451963	346542127							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472044	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccc(C)c(C)c2)n1	InChI=1S/C21H24N6O4/c1-11-5-6-15(9-12(11)2)19-26-25-18(31-19)13(3)23-20-22-8-7-17(24-20)27-16(14(4)28)10-30-21(27)29/h5-9,13-14,16,28H,10H2,1-4H3,(H,22,23,24)/t13?,14-,16-/m1/s1	SQUFVDNRWQHGQO-IGLHTZBQSA-N	247577	US10112931, Example 153::US9434719, 153::US9688672, Example 153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5990					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247577	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247577&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451940	346542117							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472045	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccc(C)c(C)c2)n1	InChI=1S/C21H24N6O4/c1-11-5-6-15(9-12(11)2)19-26-25-18(31-19)13(3)23-20-22-8-7-17(24-20)27-16(14(4)28)10-30-21(27)29/h5-9,13-14,16,28H,10H2,1-4H3,(H,22,23,24)/t13?,14-,16-/m1/s1	SQUFVDNRWQHGQO-IGLHTZBQSA-N	247577	US10112931, Example 153::US9434719, 153::US9688672, Example 153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 329					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247577	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247577&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451940	346542117							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472046	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc3ccncc23)n1	InChI=1S/C22H21N7O4/c1-12(20-27-19(28-33-20)15-5-3-4-14-6-8-23-10-16(14)15)25-21-24-9-7-18(26-21)29-17(13(2)30)11-32-22(29)31/h3-10,12-13,17,30H,11H2,1-2H3,(H,24,25,26)/t12?,13-,17-/m1/s1	HFNDQXDXAMFAAE-QQGYXAEISA-N	247578	US10112931, Example 155::US9434719, 155::US9688672, Example 155	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1790					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247578	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247578&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451954	346542118							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472047	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc3ccncc23)n1	InChI=1S/C22H21N7O4/c1-12(20-27-19(28-33-20)15-5-3-4-14-6-8-23-10-16(14)15)25-21-24-9-7-18(26-21)29-17(13(2)30)11-32-22(29)31/h3-10,12-13,17,30H,11H2,1-2H3,(H,24,25,26)/t12?,13-,17-/m1/s1	HFNDQXDXAMFAAE-QQGYXAEISA-N	247578	US10112931, Example 155::US9434719, 155::US9688672, Example 155	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 756					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247578	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247578&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451954	346542118							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472048	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)cc2C(F)(F)F)n1	InChI=1S/C20H18ClF3N6O4/c1-9(17-28-16(29-34-17)12-4-3-11(21)7-13(12)20(22,23)24)26-18-25-6-5-15(27-18)30-14(10(2)31)8-33-19(30)32/h3-7,9-10,14,31H,8H2,1-2H3,(H,25,26,27)/t9?,10-,14-/m1/s1	UXGRUBLQGMQKGE-WUMONGPASA-N	247579	US10112931, Example 157::US9434719, 157::US9688672, Example 157	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2700					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247579	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247579&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451947	346542119							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472049	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)cc2C(F)(F)F)n1	InChI=1S/C20H18ClF3N6O4/c1-9(17-28-16(29-34-17)12-4-3-11(21)7-13(12)20(22,23)24)26-18-25-6-5-15(27-18)30-14(10(2)31)8-33-19(30)32/h3-7,9-10,14,31H,8H2,1-2H3,(H,25,26,27)/t9?,10-,14-/m1/s1	UXGRUBLQGMQKGE-WUMONGPASA-N	247579	US10112931, Example 157::US9434719, 157::US9688672, Example 157	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 33					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247579	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247579&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451947	346542119							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472050	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(cc2)C(C)C)ncc1F	InChI=1S/C22H25FN6O4/c1-11(2)14-5-7-15(8-6-14)18-26-20(33-28-18)12(3)25-21-24-9-16(23)19(27-21)29-17(13(4)30)10-32-22(29)31/h5-9,11-13,17,30H,10H2,1-4H3,(H,24,25,27)/t12?,13-,17-/m1/s1	YFKNDHLPDVXSMU-QQGYXAEISA-N	247580	US10112931, Example 159::US9434719, 159::US9688672, Example 159	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247580	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247580&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451939	346542120							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472051	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(c2)C(F)(F)F)n1	InChI=1S/C20H19F3N6O4/c1-10(17-27-16(28-33-17)12-4-3-5-13(8-12)20(21,22)23)25-18-24-7-6-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)/t10?,11-,14-/m1/s1	MNEAZYGMJQUBOF-MDLDFJCZSA-N	247581	US10112931, Example 161::US9434719, 161::US9688672, Example 161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1230					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247581	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247581&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451941	346542121							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472052	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(c2)C(F)(F)F)n1	InChI=1S/C20H19F3N6O4/c1-10(17-27-16(28-33-17)12-4-3-5-13(8-12)20(21,22)23)25-18-24-7-6-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)/t10?,11-,14-/m1/s1	MNEAZYGMJQUBOF-MDLDFJCZSA-N	247581	US10112931, Example 161::US9434719, 161::US9688672, Example 161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 158					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247581	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247581&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451941	346542121							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472053	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(OC(F)(F)F)c2)n1	InChI=1S/C20H18F4N6O5/c1-9(26-18-25-6-5-15(27-18)30-13(10(2)31)8-33-19(30)32)17-28-16(29-35-17)11-3-4-12(21)14(7-11)34-20(22,23)24/h3-7,9-10,13,31H,8H2,1-2H3,(H,25,26,27)/t9?,10-,13-/m1/s1	NVQKTZLJBNQZPU-SVLLLCHKSA-N	247582	US10112931, Example 163::US9434719, 163::US9688672, Example 163	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3620					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247582	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247582&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451948	346542122							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472054	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(OC(F)(F)F)c2)n1	InChI=1S/C20H18F4N6O5/c1-9(26-18-25-6-5-15(27-18)30-13(10(2)31)8-33-19(30)32)17-28-16(29-35-17)11-3-4-12(21)14(7-11)34-20(22,23)24/h3-7,9-10,13,31H,8H2,1-2H3,(H,25,26,27)/t9?,10-,13-/m1/s1	NVQKTZLJBNQZPU-SVLLLCHKSA-N	247582	US10112931, Example 163::US9434719, 163::US9688672, Example 163	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 79					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247582	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247582&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451948	346542122							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472055	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(OC(F)F)c2)n1	InChI=1S/C20H20F2N6O5/c1-10(17-26-16(27-33-17)12-4-3-5-13(8-12)32-18(21)22)24-19-23-7-6-15(25-19)28-14(11(2)29)9-31-20(28)30/h3-8,10-11,14,18,29H,9H2,1-2H3,(H,23,24,25)/t10?,11-,14-/m1/s1	ZTGPIJZQTRQNGI-MDLDFJCZSA-N	247583	US10112931, Example 165::US9434719, 165::US9688672, Example 165	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4680					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247583	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247583&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451949	346542123							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472056	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(OC(F)F)c2)n1	InChI=1S/C20H20F2N6O5/c1-10(17-26-16(27-33-17)12-4-3-5-13(8-12)32-18(21)22)24-19-23-7-6-15(25-19)28-14(11(2)29)9-31-20(28)30/h3-8,10-11,14,18,29H,9H2,1-2H3,(H,23,24,25)/t10?,11-,14-/m1/s1	ZTGPIJZQTRQNGI-MDLDFJCZSA-N	247583	US10112931, Example 165::US9434719, 165::US9688672, Example 165	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 152					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247583	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247583&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451949	346542123							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472057	COc1cc(ccc1Cl)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O	InChI=1S/C20H21ClN6O5/c1-10(18-25-17(26-32-18)12-4-5-13(21)15(8-12)30-3)23-19-22-7-6-16(24-19)27-14(11(2)28)9-31-20(27)29/h4-8,10-11,14,28H,9H2,1-3H3,(H,22,23,24)/t10?,11-,14-/m1/s1	HCGGGZYFGAZWQP-MDLDFJCZSA-N	247584	US10112931, Example 167::US9434719, 167::US9688672, Example 167	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 871					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247584	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247584&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451942	346542124							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472058	COc1cc(ccc1Cl)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O	InChI=1S/C20H21ClN6O5/c1-10(18-25-17(26-32-18)12-4-5-13(21)15(8-12)30-3)23-19-22-7-6-16(24-19)27-14(11(2)28)9-31-20(27)29/h4-8,10-11,14,28H,9H2,1-3H3,(H,22,23,24)/t10?,11-,14-/m1/s1	HCGGGZYFGAZWQP-MDLDFJCZSA-N	247584	US10112931, Example 167::US9434719, 167::US9688672, Example 167	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 131					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247584	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247584&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451942	346542124							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472059	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc3OC(F)(F)Oc3c2)n1	InChI=1S/C20H18F2N6O6/c1-9(24-18-23-6-5-15(25-18)28-12(10(2)29)8-31-19(28)30)17-26-16(27-34-17)11-3-4-13-14(7-11)33-20(21,22)32-13/h3-7,9-10,12,29H,8H2,1-2H3,(H,23,24,25)/t9?,10-,12-/m1/s1	RGPKYJCYYMOGBR-GTFYECCDSA-N	247585	US10112931, Example 169::US9434719, 169::US9688672, Example 169	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3200					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247585	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247585&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451955	346542125							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472060	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc3OC(F)(F)Oc3c2)n1	InChI=1S/C20H18F2N6O6/c1-9(24-18-23-6-5-15(25-18)28-12(10(2)29)8-31-19(28)30)17-26-16(27-34-17)11-3-4-13-14(7-11)33-20(21,22)32-13/h3-7,9-10,12,29H,8H2,1-2H3,(H,23,24,25)/t9?,10-,12-/m1/s1	RGPKYJCYYMOGBR-GTFYECCDSA-N	247585	US10112931, Example 169::US9434719, 169::US9688672, Example 169	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 38					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247585	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247585&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451955	346542125							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472061	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)c(c2)C(F)(F)F)n1	InChI=1S/C20H18ClF3N6O4/c1-9(17-28-16(29-34-17)11-3-4-13(21)12(7-11)20(22,23)24)26-18-25-6-5-15(27-18)30-14(10(2)31)8-33-19(30)32/h3-7,9-10,14,31H,8H2,1-2H3,(H,25,26,27)/t9?,10-,14-/m1/s1	DNPZDRUUCRRSIU-WUMONGPASA-N	247586	US10112931, Example 171::US9434719, 171::US9688672, Example 171	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3690					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247586	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247586&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451950	346542126							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472062	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)c(c2)C(F)(F)F)n1	InChI=1S/C20H18ClF3N6O4/c1-9(17-28-16(29-34-17)11-3-4-13(21)12(7-11)20(22,23)24)26-18-25-6-5-15(27-18)30-14(10(2)31)8-33-19(30)32/h3-7,9-10,14,31H,8H2,1-2H3,(H,25,26,27)/t9?,10-,14-/m1/s1	DNPZDRUUCRRSIU-WUMONGPASA-N	247586	US10112931, Example 171::US9434719, 171::US9688672, Example 171	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 56					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247586	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247586&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451950	346542126							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472063	CCc1ccc(cc1)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O	InChI=1S/C21H24N6O4/c1-4-14-5-7-15(8-6-14)18-25-19(31-26-18)12(2)23-20-22-10-9-17(24-20)27-16(13(3)28)11-30-21(27)29/h5-10,12-13,16,28H,4,11H2,1-3H3,(H,22,23,24)/t12?,13-,16-/m1/s1	WWQSBBFDNJQGEO-LLQOJDTPSA-N	247587	US10112931, Example 173::US9434719, 173::US9688672, Example 173	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 65					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247587	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247587&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451963	346542127							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472064	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(cc2)C(F)(F)F)n1	InChI=1S/C20H19F3N6O4/c1-10(17-27-16(28-33-17)12-3-5-13(6-4-12)20(21,22)23)25-18-24-8-7-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)/t10?,11-,14-/m1/s1	QLENNUPBCLQXOM-MDLDFJCZSA-N	247588	US10112931, Example 175::US9434719, 175::US9688672, Example 175	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 230					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247588	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247588&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451964	346542128							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472065	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(cc2)C(F)(F)F)n1	InChI=1S/C20H19F3N6O4/c1-10(17-27-16(28-33-17)12-3-5-13(6-4-12)20(21,22)23)25-18-24-8-7-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)/t10?,11-,14-/m1/s1	QLENNUPBCLQXOM-MDLDFJCZSA-N	247588	US10112931, Example 175::US9434719, 175::US9688672, Example 175	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 418					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247588	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247588&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451964	346542128							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472066	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(CCc3ccccc3)no2)n1	InChI=1S/C21H24N6O4/c1-13(19-24-17(26-31-19)9-8-15-6-4-3-5-7-15)23-20-22-11-10-18(25-20)27-16(14(2)28)12-30-21(27)29/h3-7,10-11,13-14,16,28H,8-9,12H2,1-2H3,(H,22,23,25)/t13?,14-,16-/m1/s1	LXDWPRMFMLFXHK-IGLHTZBQSA-N	247589	US10112931, Example 177::US9434719, 177::US9688672, Example 177	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12400					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247589	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247589&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451952	346542129							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472067	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(CCc3ccccc3)no2)n1	InChI=1S/C21H24N6O4/c1-13(19-24-17(26-31-19)9-8-15-6-4-3-5-7-15)23-20-22-11-10-18(25-20)27-16(14(2)28)12-30-21(27)29/h3-7,10-11,13-14,16,28H,8-9,12H2,1-2H3,(H,22,23,25)/t13?,14-,16-/m1/s1	LXDWPRMFMLFXHK-IGLHTZBQSA-N	247589	US10112931, Example 177::US9434719, 177::US9688672, Example 177	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1230					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247589	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247589&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451952	346542129							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472068	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(Cl)c(OC(F)(F)F)c2)ncc1F	InChI=1S/C20H17ClF4N6O5/c1-8(17-28-15(30-36-17)10-3-4-11(21)14(5-10)35-20(23,24)25)27-18-26-6-12(22)16(29-18)31-13(9(2)32)7-34-19(31)33/h3-6,8-9,13,32H,7H2,1-2H3,(H,26,27,29)/t8?,9-,13-/m1/s1	WXPAQCJZFINGNQ-VPQWPZGESA-N	247590	US10112931, Example 179::US9434719, 179::US9688672, Example 179	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 364					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247590	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247590&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451959	346542130							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472069	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(Cl)c(OC(F)(F)F)c2)ncc1F	InChI=1S/C20H17ClF4N6O5/c1-8(17-28-15(30-36-17)10-3-4-11(21)14(5-10)35-20(23,24)25)27-18-26-6-12(22)16(29-18)31-13(9(2)32)7-34-19(31)33/h3-6,8-9,13,32H,7H2,1-2H3,(H,26,27,29)/t8?,9-,13-/m1/s1	WXPAQCJZFINGNQ-VPQWPZGESA-N	247590	US10112931, Example 179::US9434719, 179::US9688672, Example 179	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7.00					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247590	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247590&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451959	346542130							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472070	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(OC(F)(F)F)cc2)n1	InChI=1S/C20H19F3N6O5/c1-10(17-27-16(28-34-17)12-3-5-13(6-4-12)33-20(21,22)23)25-18-24-8-7-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)/t10?,11-,14-/m1/s1	VFQOXIRRHLWYFA-MDLDFJCZSA-N	247591	US10112931, Example 181::US9434719, 181::US9688672, Example 181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247591	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247591&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451957	346542131							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472071	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(OC(F)(F)F)cc2)n1	InChI=1S/C20H19F3N6O5/c1-10(17-27-16(28-34-17)12-3-5-13(6-4-12)33-20(21,22)23)25-18-24-8-7-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)/t10?,11-,14-/m1/s1	VFQOXIRRHLWYFA-MDLDFJCZSA-N	247591	US10112931, Example 181::US9434719, 181::US9688672, Example 181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 138					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247591	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247591&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451957	346542131							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472072	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(OCC(F)(F)F)c2)n1	InChI=1S/C21H21F3N6O5/c1-11(26-19-25-7-6-16(27-19)30-15(12(2)31)9-33-20(30)32)18-28-17(29-35-18)13-4-3-5-14(8-13)34-10-21(22,23)24/h3-8,11-12,15,31H,9-10H2,1-2H3,(H,25,26,27)/t11?,12-,15-/m1/s1	QSGYHXIUNUAHLH-AADWAWOOSA-N	247592	US10112931, Example 183::US9434719, 183::US9688672, Example 183	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1920					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247592	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247592&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451966	346542132							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472073	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(OCC(F)(F)F)c2)n1	InChI=1S/C21H21F3N6O5/c1-11(26-19-25-7-6-16(27-19)30-15(12(2)31)9-33-20(30)32)18-28-17(29-35-18)13-4-3-5-14(8-13)34-10-21(22,23)24/h3-8,11-12,15,31H,9-10H2,1-2H3,(H,25,26,27)/t11?,12-,15-/m1/s1	QSGYHXIUNUAHLH-AADWAWOOSA-N	247592	US10112931, Example 183::US9434719, 183::US9688672, Example 183	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 128					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247592	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247592&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451966	346542132							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472074	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(C)c(o2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H22ClN5O4/c1-11-18(14-4-6-15(22)7-5-14)31-19(24-11)12(2)25-20-23-9-8-17(26-20)27-16(13(3)28)10-30-21(27)29/h4-9,12-13,16,28H,10H2,1-3H3,(H,23,25,26)/t12?,13-,16-/m1/s1	ADOKVKMNXUWJLY-LLQOJDTPSA-N	247593	US10112931, Example 185::US9434719, 185::US9688672, Example 185	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 502					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247593	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247593&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451951	346542133							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472075	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(C)c(o2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H22ClN5O4/c1-11-18(14-4-6-15(22)7-5-14)31-19(24-11)12(2)25-20-23-9-8-17(26-20)27-16(13(3)28)10-30-21(27)29/h4-9,12-13,16,28H,10H2,1-3H3,(H,23,25,26)/t12?,13-,16-/m1/s1	ADOKVKMNXUWJLY-LLQOJDTPSA-N	247593	US10112931, Example 185::US9434719, 185::US9688672, Example 185	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 23					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247593	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247593&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451951	346542133							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472076	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(C)c(o2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C21H21ClFN5O4/c1-10-17(13-4-6-14(22)7-5-13)32-19(25-10)11(2)26-20-24-8-15(23)18(27-20)28-16(12(3)29)9-31-21(28)30/h4-8,11-12,16,29H,9H2,1-3H3,(H,24,26,27)/t11?,12-,16-/m1/s1	HLHUIGPXIQCWLI-ZLXOECBPSA-N	247594	US10112931, Example 187::US9434719, 187::US9688672, Example 187	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2450					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247594	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247594&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451960	346542134							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472077	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(C)c(o2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C21H21ClFN5O4/c1-10-17(13-4-6-14(22)7-5-13)32-19(25-10)11(2)26-20-24-8-15(23)18(27-20)28-16(12(3)29)9-31-21(28)30/h4-8,11-12,16,29H,9H2,1-3H3,(H,24,26,27)/t11?,12-,16-/m1/s1	HLHUIGPXIQCWLI-ZLXOECBPSA-N	247594	US10112931, Example 187::US9434719, 187::US9688672, Example 187	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 22					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247594	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247594&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451960	346542134							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472078	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(c(C)s2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H22ClN5O3S/c1-11(19-26-18(13(3)31-19)14-4-6-15(22)7-5-14)24-20-23-9-8-17(25-20)27-16(12(2)28)10-30-21(27)29/h4-9,11-12,16,28H,10H2,1-3H3,(H,23,24,25)/t11?,12-,16-/m1/s1	AIVKCQOVERPJLV-ZLXOECBPSA-N	247595	US10112931, Example 189::US9434719, 189::US9688672, Example 189	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 8380					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247595	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247595&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451927	346542135							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472079	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(c(C)s2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H22ClN5O3S/c1-11(19-26-18(13(3)31-19)14-4-6-15(22)7-5-14)24-20-23-9-8-17(25-20)27-16(12(2)28)10-30-21(27)29/h4-9,11-12,16,28H,10H2,1-3H3,(H,23,24,25)/t11?,12-,16-/m1/s1	AIVKCQOVERPJLV-ZLXOECBPSA-N	247595	US10112931, Example 189::US9434719, 189::US9688672, Example 189	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 64					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247595	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247595&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451927	346542135							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472080	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(cs2)-c2ccc(Br)cc2)ncc1F	InChI=1S/C20H19BrFN5O3S/c1-10(18-25-15(9-31-18)12-3-5-13(21)6-4-12)24-19-23-7-14(22)17(26-19)27-16(11(2)28)8-30-20(27)29/h3-7,9-11,16,28H,8H2,1-2H3,(H,23,24,26)/t10?,11-,16-/m1/s1	DELZMXCYLPWIQP-MKYLOTPESA-N	247596	US10112931, Example 191::US9434719, 191::US9688672, Example 191	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 37					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247596	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247596&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451968	346542136							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472081	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(cs2)-c2ccc(Br)cc2)ncc1F	InChI=1S/C20H19BrFN5O3S/c1-10(18-25-15(9-31-18)12-3-5-13(21)6-4-12)24-19-23-7-14(22)17(26-19)27-16(11(2)28)8-30-20(27)29/h3-7,9-11,16,28H,8H2,1-2H3,(H,23,24,26)/t10?,11-,16-/m1/s1	DELZMXCYLPWIQP-MKYLOTPESA-N	247596	US10112931, Example 191::US9434719, 191::US9688672, Example 191	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>50000					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247596	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247596&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451968	346542136							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472082	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(c(C)c2)C(F)(F)F)n1	InChI=1S/C23H23F3N6O3/c1-12-8-15(4-5-17(12)23(24,25)26)16-9-28-20(29-10-16)13(2)30-21-27-7-6-19(31-21)32-18(14(3)33)11-35-22(32)34/h4-10,13-14,18,33H,11H2,1-3H3,(H,27,30,31)/t13?,14-,18-/m1/s1	IMQCNVNUOCMQLX-JDPNFYKBSA-N	247598	US10112931, Example 195::US9434719, 195::US9688672, Example 195	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 51					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247598	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247598&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451953	346542138							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472083	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(c(C)c2)C(F)(F)F)n1	InChI=1S/C23H23F3N6O3/c1-12-8-15(4-5-17(12)23(24,25)26)16-9-28-20(29-10-16)13(2)30-21-27-7-6-19(31-21)32-18(14(3)33)11-35-22(32)34/h4-10,13-14,18,33H,11H2,1-3H3,(H,27,30,31)/t13?,14-,18-/m1/s1	IMQCNVNUOCMQLX-JDPNFYKBSA-N	247598	US10112931, Example 195::US9434719, 195::US9688672, Example 195	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2930					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247598	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247598&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451953	346542138							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472084	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(C)c(s2)-c2ccnc(c2)C(C)(C)C(F)(F)F)n1	InChI=1S/C24H27F3N6O3S/c1-12-19(15-6-8-28-17(10-15)23(4,5)24(25,26)27)37-20(30-12)13(2)31-21-29-9-7-18(32-21)33-16(14(3)34)11-36-22(33)35/h6-10,13-14,16,34H,11H2,1-5H3,(H,29,31,32)/t13?,14-,16-/m1/s1	USESWMZOECWBKB-IGLHTZBQSA-N	247599	US10112931, Example 197::US9434719, 197::US9688672, Example 197	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247599	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247599&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451956	346542139							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472085	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(C)c(s2)-c2ccnc(c2)C(C)(C)C(F)(F)F)n1	InChI=1S/C24H27F3N6O3S/c1-12-19(15-6-8-28-17(10-15)23(4,5)24(25,26)27)37-20(30-12)13(2)31-21-29-9-7-18(32-21)33-16(14(3)34)11-36-22(33)35/h6-10,13-14,16,34H,11H2,1-5H3,(H,29,31,32)/t13?,14-,16-/m1/s1	USESWMZOECWBKB-IGLHTZBQSA-N	247599	US10112931, Example 197::US9434719, 197::US9688672, Example 197	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2010					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247599	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247599&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451956	346542139							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472086	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(C)c(s2)-c2ccnc(c2)C(C)(C)C(F)(F)F)ncc1F	InChI=1S/C24H26F4N6O3S/c1-11-18(14-6-7-29-17(8-14)23(4,5)24(26,27)28)38-20(31-11)12(2)32-21-30-9-15(25)19(33-21)34-16(13(3)35)10-37-22(34)36/h6-9,12-13,16,35H,10H2,1-5H3,(H,30,32,33)/t12?,13-,16-/m1/s1	UQINMWIGODPXCQ-LLQOJDTPSA-N	247600	US10112931, Example 199::US9434719, 199::US9688672, Example 199	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247600	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247600&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451958	346542140							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472087	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(C)c(s2)-c2ccnc(c2)C(C)(C)C(F)(F)F)ncc1F	InChI=1S/C24H26F4N6O3S/c1-11-18(14-6-7-29-17(8-14)23(4,5)24(26,27)28)38-20(31-11)12(2)32-21-30-9-15(25)19(33-21)34-16(13(3)35)10-37-22(34)36/h6-9,12-13,16,35H,10H2,1-5H3,(H,30,32,33)/t12?,13-,16-/m1/s1	UQINMWIGODPXCQ-LLQOJDTPSA-N	247600	US10112931, Example 199::US9434719, 199::US9688672, Example 199	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1200					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247600	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247600&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451958	346542140							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472088	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cccc(c2F)C(F)(F)F)n1	InChI=1S/C22H20F4N6O3/c1-11(30-20-27-7-6-17(31-20)32-16(12(2)33)10-35-21(32)34)19-28-8-13(9-29-19)14-4-3-5-15(18(14)23)22(24,25)26/h3-9,11-12,16,33H,10H2,1-2H3,(H,27,30,31)/t11?,12-,16-/m1/s1	OMLKQWGXCCTPMV-ZLXOECBPSA-N	247601	US10112931, Example 201::US9434719, 201::US9688672, Example 201	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 43					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247601	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247601&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451969	346542141							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472089	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cccc(c2F)C(F)(F)F)n1	InChI=1S/C22H20F4N6O3/c1-11(30-20-27-7-6-17(31-20)32-16(12(2)33)10-35-21(32)34)19-28-8-13(9-29-19)14-4-3-5-15(18(14)23)22(24,25)26/h3-9,11-12,16,33H,10H2,1-2H3,(H,27,30,31)/t11?,12-,16-/m1/s1	OMLKQWGXCCTPMV-ZLXOECBPSA-N	247601	US10112931, Example 201::US9434719, 201::US9688672, Example 201	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 344					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247601	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247601&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451969	346542141							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472090	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2ncc(o2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C20H19ClFN5O4/c1-10(18-23-8-16(31-18)12-3-5-13(21)6-4-12)25-19-24-7-14(22)17(26-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,24,25,26)/t10?,11-,15-/m1/s1	HEDYPYHSULZALW-HUFXEGEASA-N	247602	US10112931, Example 203::US9434719, 203::US9688672, Example 203	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1680					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247602	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247602&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415519	346542142							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472091	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2ncc(o2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C20H19ClFN5O4/c1-10(18-23-8-16(31-18)12-3-5-13(21)6-4-12)25-19-24-7-14(22)17(26-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,24,25,26)/t10?,11-,15-/m1/s1	HEDYPYHSULZALW-HUFXEGEASA-N	247602	US10112931, Example 203::US9434719, 203::US9688672, Example 203	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 16					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247602	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247602&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415519	346542142							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472092	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H20ClN5O4/c1-11(17-9-15(25-30-17)13-3-5-14(21)6-4-13)23-19-22-8-7-18(24-19)26-16(12(2)27)10-29-20(26)28/h3-9,11-12,16,27H,10H2,1-2H3,(H,22,23,24)/t11?,12-,16-/m1/s1	QCIXJXCZOHQOBC-ZLXOECBPSA-N	247603	US10112931, Example 205::US9434719, 205::US9688672, Example 205	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 42					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247603	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247603&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415804	346542143							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472093	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H20ClN5O4/c1-11(17-9-15(25-30-17)13-3-5-14(21)6-4-13)23-19-22-8-7-18(24-19)26-16(12(2)27)10-29-20(26)28/h3-9,11-12,16,27H,10H2,1-2H3,(H,22,23,24)/t11?,12-,16-/m1/s1	QCIXJXCZOHQOBC-ZLXOECBPSA-N	247603	US10112931, Example 205::US9434719, 205::US9688672, Example 205	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2700					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247603	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247603&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415804	346542143							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472094	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(o2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H20ClN5O4/c1-11(18-23-9-16(30-18)13-3-5-14(21)6-4-13)24-19-22-8-7-17(25-19)26-15(12(2)27)10-29-20(26)28/h3-9,11-12,15,27H,10H2,1-2H3,(H,22,24,25)/t11-,12+,15+/m0/s1	HIUAGIMKSPVCLG-YWPYICTPSA-N	247604	US10112931, Example 206::US9434719, 206::US9688672, Example 206	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 40					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247604	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247604&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269208	346542144							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472095	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2nc(no2)-c2ccc(Cl)cc2)n1	InChI=1S/C19H18Cl2N6O4/c1-9(17-25-16(26-31-17)11-3-5-12(20)6-4-11)22-18-23-14(21)7-15(24-18)27-13(10(2)28)8-30-19(27)29/h3-7,9-10,13,28H,8H2,1-2H3,(H,22,23,24)/t9-,10+,13+/m0/s1	NCBFXUOWZFTIAL-OPQQBVKSSA-N	247605	US10112931, Example 207::US9434719, 207 as TFA salt::US9688672, Example 207	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247605	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247605&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414365	346542145							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472096	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(cc2F)C(F)(F)F)n1	InChI=1S/C18H17ClF4N4O3/c1-8(11-4-3-10(5-12(11)20)18(21,22)23)24-16-25-14(19)6-15(26-16)27-13(9(2)28)7-30-17(27)29/h3-6,8-9,13,28H,7H2,1-2H3,(H,24,25,26)/t8-,9+,13+/m0/s1	NXXCBQQBPMJPJP-IGJMFERPSA-N	247606	US10112931, Example 208::US9434719, 208 as TFA salt::US9688672, Example 208	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 101					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247606	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247606&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451962	346542146							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472097	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(cc2F)-c2cnn(C)c2)n1	InChI=1S/C21H22ClFN6O3/c1-11(15-5-4-13(6-16(15)23)14-8-24-28(3)9-14)25-20-26-18(22)7-19(27-20)29-17(12(2)30)10-32-21(29)31/h4-9,11-12,17,30H,10H2,1-3H3,(H,25,26,27)/t11-,12+,17+/m0/s1	XETISXFEDFMUSI-XWCIJXRUSA-N	247607	US10112931, Example 209::US9434719, 209 as TFA salt::US9688672, Example 209	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 87					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247607	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247607&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451967	346542147							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472098	C[C@@H](O)[C@H]1COC(=O)N1c1cc(nc(N[C@@H](C)c2nc(no2)-c2ccc(Cl)cc2)n1)C(F)F	InChI=1S/C20H19ClF2N6O4/c1-9(18-27-17(28-33-18)11-3-5-12(21)6-4-11)24-19-25-13(16(22)23)7-15(26-19)29-14(10(2)30)8-32-20(29)31/h3-7,9-10,14,16,30H,8H2,1-2H3,(H,24,25,26)/t9-,10+,14+/m0/s1	WXLQCKHIONRIQN-IMSIIYSGSA-N	247608	US10112931, Example 210::US9434719, 210 as TFA salt::US9688672, Example 210	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 153					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247608	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247608&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451965	346542148							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472099	C[C@@H](O)[C@H]1COC(=O)N1c1cc(nc(N[C@@H](C)c2nc(no2)-c2ccc(Cl)cc2)n1)C(F)(F)F	InChI=1S/C20H18ClF3N6O4/c1-9(17-28-16(29-34-17)11-3-5-12(21)6-4-11)25-18-26-14(20(22,23)24)7-15(27-18)30-13(10(2)31)8-33-19(30)32/h3-7,9-10,13,31H,8H2,1-2H3,(H,25,26,27)/t9-,10+,13+/m0/s1	QFFYIIBUJFALQY-OPQQBVKSSA-N	247609	US10112931, Example 211::US9434719, 211 as TFA salt::US9688672, Example 211	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 496					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247609	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247609&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451970	346542149							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472100	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(n1)[C@@H](C)c1cc(F)c(cc1F)-c1cnn(C)c1	InChI=1S/C21H20ClF2N5O3/c1-10(13-4-16(24)14(5-15(13)23)12-7-25-28(3)8-12)20-26-18(22)6-19(27-20)29-17(11(2)30)9-32-21(29)31/h4-8,10-11,17,30H,9H2,1-3H3/t10-,11+,17+/m0/s1	DHUAMXPDUGZPMC-WVQJBOLRSA-N	247610	US10112931, Example 212::US9434719, 212 as TFA salt::US9688672, Example 212	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 35					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247610	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247610&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451971	346542150							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472101	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H19Cl2N5O4/c1-10(14-7-16(31-26-14)12-3-5-13(21)6-4-12)23-19-24-17(22)8-18(25-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,23,24,25)/t10-,11+,15+/m0/s1	IPBYIAIAZKELOY-FIXISWKDSA-N	175219	US10112931, Example 213::US9688672, Example 213	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175219&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451973	363892296							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472102	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H19Cl2N5O4/c1-10(14-7-16(31-26-14)12-3-5-13(21)6-4-12)23-19-24-17(22)8-18(25-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,23,24,25)/t10-,11+,15+/m0/s1	IPBYIAIAZKELOY-FIXISWKDSA-N	175219	US10112931, Example 213::US9688672, Example 213	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 19					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175219&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451973	363892296							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472103	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(on2)-c2ccccc2)n1	InChI=1S/C20H20ClN5O4/c1-11(14-8-16(30-25-14)13-6-4-3-5-7-13)22-19-23-17(21)9-18(24-19)26-15(12(2)27)10-29-20(26)28/h3-9,11-12,15,27H,10H2,1-2H3,(H,22,23,24)/t11-,12+,15+/m0/s1	XAZFNUFCRZJXGB-YWPYICTPSA-N	247612	US10112931, Example 214::US9434719, 214 as TFA salt::US9688672, Example 214	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 46					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247612	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247612&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451974	346542152							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472104	C[C@@H](O)[C@H]1COC(=O)N1c1cc(F)nc(N[C@@H](C)c2cnn(c2)-c2ccc(F)cc2)n1	InChI=1S/C20H20F2N6O3/c1-11(13-8-23-27(9-13)15-5-3-14(21)4-6-15)24-19-25-17(22)7-18(26-19)28-16(12(2)29)10-31-20(28)30/h3-9,11-12,16,29H,10H2,1-2H3,(H,24,25,26)/t11-,12+,16+/m0/s1	TYFOBZWTJHMKET-HWWQOWPSSA-N	247613	US10112931, Example 215::US9434719, 215 as TFA salt::US9688672, Example 215	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 55					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247613	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247613&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118121703	346542153							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472105	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H19Cl2N5O3S/c1-10(15-8-23-18(31-15)12-3-5-13(21)6-4-12)24-19-25-16(22)7-17(26-19)27-14(11(2)28)9-30-20(27)29/h3-8,10-11,14,28H,9H2,1-2H3,(H,24,25,26)/t10-,11+,14+/m0/s1	GATAMUFLGVCKNZ-MISXGVKJSA-N	247614	US10112931, Example 216::US9434719, 216 as TFA salt::US9688672, Example 216	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4.00					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247614	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247614&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451972	346542154							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472106	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C20H19ClFN5O3S/c1-10(16-8-23-18(31-16)12-3-5-13(21)6-4-12)25-19-24-7-14(22)17(26-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,24,25,26)/t10-,11+,15+/m0/s1	WUFHWWGCPRCXLY-FIXISWKDSA-N	247615	US10112931, Example 217::US9434719, 217 as TFA salt::US9688672, Example 217	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 22					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247615	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247615&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269209	346542155							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472107	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C20H19ClFN5O4/c1-10(15-7-17(31-26-15)12-3-5-13(21)6-4-12)24-19-23-8-14(22)18(25-19)27-16(11(2)28)9-30-20(27)29/h3-8,10-11,16,28H,9H2,1-2H3,(H,23,24,25)/t10-,11+,16+/m0/s1	NFYDSEIEOVKCOW-LYOVBCGYSA-N	247616	US10112931, Example 218::US9434719, 218 as TFA salt::US9688672, Example 218	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 19					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247616	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247616&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451976	346542156							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472108	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2nnc(s2)-c2ccc(Cl)cc2)n1	InChI=1S/C19H18Cl2N6O3S/c1-9(16-25-26-17(31-16)11-3-5-12(20)6-4-11)22-18-23-14(21)7-15(24-18)27-13(10(2)28)8-30-19(27)29/h3-7,9-10,13,28H,8H2,1-2H3,(H,22,23,24)/t9-,10+,13+/m0/s1	RAIZFAORMPTPAT-OPQQBVKSSA-N	247617	US10112931, Example 219::US9434719, 219 as TFA salt::US9688672, Example 219	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247617	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247617&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451975	346542157							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472109	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H20Cl2N6O3/c1-11(13-8-23-27(9-13)15-5-3-14(21)4-6-15)24-19-25-17(22)7-18(26-19)28-16(12(2)29)10-31-20(28)30/h3-9,11-12,16,29H,10H2,1-2H3,(H,24,25,26)/t11-,12+,16+/m0/s1	GLNIOVVBUOTMDV-HWWQOWPSSA-N	247618	US10112931, Example 220::US9434719, 220 as TFA salt::US9688672, Example 220	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247618	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247618&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451977	346542158							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472110	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C20H20ClFN6O3/c1-11(13-7-24-27(9-13)15-5-3-14(21)4-6-15)25-19-23-8-16(22)18(26-19)28-17(12(2)29)10-31-20(28)30/h3-9,11-12,17,29H,10H2,1-2H3,(H,23,25,26)/t11-,12+,17+/m0/s1	GRZJNGBTAXSJAT-XWCIJXRUSA-N	247619	US10112931, Example 221::US9434719, 221::US9688672, Example 221	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 61					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247619	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247619&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451978	346542159							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472111	C[C@@H](O)[C@H]1COC(=O)N1c1cc(CF)nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H21ClFN5O4/c1-11(16-8-18(32-27-16)13-3-5-14(22)6-4-13)24-20-25-15(9-23)7-19(26-20)28-17(12(2)29)10-31-21(28)30/h3-8,11-12,17,29H,9-10H2,1-2H3,(H,24,25,26)/t11-,12+,17+/m0/s1	XGWSEQREFWTISB-XWCIJXRUSA-N	247620	US10112931, Example 222::US9434719, 222 as TFA salt::US9688672, Example 222	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 47					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247620	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247620&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451979	346542160							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472112	C[C@@H](O)[C@H]1COC(=O)N1c1cc(CF)nc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H21ClFN5O3S/c1-11(17-9-24-19(32-17)13-3-5-14(22)6-4-13)25-20-26-15(8-23)7-18(27-20)28-16(12(2)29)10-31-21(28)30/h3-7,9,11-12,16,29H,8,10H2,1-2H3,(H,25,26,27)/t11-,12+,16+/m0/s1	RAIMVJDXPWQXGV-HWWQOWPSSA-N	247621	US10112931, Example 223::US9434719, 223 as TFA salt::US9688672, Example 223	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 35					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247621	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247621&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269210	346542161							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472113	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H20ClN5O3S/c1-11(16-9-23-18(30-16)13-3-5-14(21)6-4-13)24-19-22-8-7-17(25-19)26-15(12(2)27)10-29-20(26)28/h3-9,11-12,15,27H,10H2,1-2H3,(H,22,24,25)/t11-,12+,15+/m0/s1	GVHVMKBUEILJFX-YWPYICTPSA-N	247622	US10112931, Example 224::US9434719, 224::US9688672, Example 224	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247622	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247622&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269412	346542162							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472114	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H20ClN5O3S/c1-11(16-9-23-18(30-16)13-3-5-14(21)6-4-13)24-19-22-8-7-17(25-19)26-15(12(2)27)10-29-20(26)28/h3-9,11-12,15,27H,10H2,1-2H3,(H,22,24,25)/t11-,12+,15+/m0/s1	GVHVMKBUEILJFX-YWPYICTPSA-N	247622	US10112931, Example 224::US9434719, 224::US9688672, Example 224	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247622	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247622&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269412	346542162							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472115	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H21ClN6O3/c1-12(14-9-23-26(10-14)16-5-3-15(21)4-6-16)24-19-22-8-7-18(25-19)27-17(13(2)28)11-30-20(27)29/h3-10,12-13,17,28H,11H2,1-2H3,(H,22,24,25)/t12-,13+,17+/m0/s1	OQBOQQPZTMRUOB-OGHNNQOOSA-N	247623	US10112931, Example 225::US9434719, 225::US9688672, Example 225	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 37					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247623	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247623&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269413	346542163							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472116	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H21ClN6O3/c1-12(14-9-23-26(10-14)16-5-3-15(21)4-6-16)24-19-22-8-7-18(25-19)27-17(13(2)28)11-30-20(27)29/h3-10,12-13,17,28H,11H2,1-2H3,(H,22,24,25)/t12-,13+,17+/m0/s1	OQBOQQPZTMRUOB-OGHNNQOOSA-N	247623	US10112931, Example 225::US9434719, 225::US9688672, Example 225	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 35					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247623	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247623&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269413	346542163							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472117	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(no2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H19Cl2N5O4/c1-10(16-7-14(26-31-16)12-3-5-13(21)6-4-12)23-19-24-17(22)8-18(25-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,23,24,25)/t10-,11+,15+/m0/s1	SFLSLKNYLURLGQ-FIXISWKDSA-N	247624	US10112931, Example 226::US9434719, 226 as TFA salt::US9688672, Example 226	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 9.00					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247624	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247624&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451980	346542164							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472118	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(no2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C20H19ClFN5O4/c1-10(17-7-15(26-31-17)12-3-5-13(21)6-4-12)24-19-23-8-14(22)18(25-19)27-16(11(2)28)9-30-20(27)29/h3-8,10-11,16,28H,9H2,1-2H3,(H,23,24,25)/t10-,11+,16+/m0/s1	AJHHRHLQOWGOMY-LYOVBCGYSA-N	247625	US10112931, Example 227::US9434719, 227 as TFA salt::US9688672, Example 227	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 15					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247625	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247625&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451983	346542165							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472119	C[C@@H](O)[C@H]1COC(=O)N1c1cc(F)nc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H20ClFN6O3/c1-11(13-8-23-27(9-13)15-5-3-14(21)4-6-15)24-19-25-17(22)7-18(26-19)28-16(12(2)29)10-31-20(28)30/h3-9,11-12,16,29H,10H2,1-2H3,(H,24,25,26)/t11-,12+,16+/m0/s1	CUCKGGUBBMYMRU-HWWQOWPSSA-N	247626	US10112931, Example 228::US9434719, 228::US9688672, Example 228	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 19					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247626	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247626&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451981	346542166							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472120	C[C@@H](O)[C@H]1COC(=O)N1c1cc(F)nc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H20ClFN6O3/c1-11(13-8-23-27(9-13)15-5-3-14(21)4-6-15)24-19-25-17(22)7-18(26-19)28-16(12(2)29)10-31-20(28)30/h3-9,11-12,16,29H,10H2,1-2H3,(H,24,25,26)/t11-,12+,16+/m0/s1	CUCKGGUBBMYMRU-HWWQOWPSSA-N	247626	US10112931, Example 228::US9434719, 228::US9688672, Example 228	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247626	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247626&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451981	346542166							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472121	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(on2)-c2ccc(F)cc2)n1	InChI=1S/C20H19ClFN5O4/c1-10(14-7-16(31-26-14)12-3-5-13(22)6-4-12)23-19-24-17(21)8-18(25-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,23,24,25)/t10-,11+,15+/m0/s1	TWNZHXTWQYYGKW-FIXISWKDSA-N	247627	US10112931, Example 229::US9434719, 229 as TFA salt::US9688672, Example 229	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 54					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247627	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247627&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451982	346542167							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472122	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(CN3CCOCC3)on2)n1	InChI=1S/C19H25ClN6O5/c1-11(14-7-13(31-24-14)9-25-3-5-29-6-4-25)21-18-22-16(20)8-17(23-18)26-15(12(2)27)10-30-19(26)28/h7-8,11-12,15,27H,3-6,9-10H2,1-2H3,(H,21,22,23)/t11-,12+,15+/m0/s1	YSHMQMUGIYMHNN-YWPYICTPSA-N	247628	US10112931, Example 230::US9434719, 230 as TFA salt::US9688672, Example 230	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247628	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247628&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451985	346542168							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472123	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@H](C)c2cc(CN3CCOCC3)on2)n1	InChI=1S/C19H25ClN6O5/c1-11(14-7-13(31-24-14)9-25-3-5-29-6-4-25)21-18-22-16(20)8-17(23-18)26-15(12(2)27)10-30-19(26)28/h7-8,11-12,15,27H,3-6,9-10H2,1-2H3,(H,21,22,23)/t11-,12-,15-/m1/s1	YSHMQMUGIYMHNN-LALPHHSUSA-N	247629	US10112931, Example 231::US9434719, 231 as TFA salt::US9688672, Example 231	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247629	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247629&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451984	346542169							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472124	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H23ClN6O3/c1-12-8-19(28-18(14(3)29)11-31-21(28)30)26-20(24-12)25-13(2)15-9-23-27(10-15)17-6-4-16(22)5-7-17/h4-10,13-14,18,29H,11H2,1-3H3,(H,24,25,26)/t13-,14+,18+/m0/s1	IBQFUTIPFZCCSX-PMUMKWKESA-N	247630	US10112931, Example 232::US9434719, 232 as TFA salt::US9688672, Example 232	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 24					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247630	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247630&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451990	346542170							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472125	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cnc(s2)-c2ccccn2)n1	InChI=1S/C19H19ClN6O3S/c1-10(14-8-22-17(30-14)12-5-3-4-6-21-12)23-18-24-15(20)7-16(25-18)26-13(11(2)27)9-29-19(26)28/h3-8,10-11,13,27H,9H2,1-2H3,(H,23,24,25)/t10-,11+,13+/m0/s1	XGBORLPZEYFPOL-DMDPSCGWSA-N	247631	US10112931, Example 233::US9434719, 233 as TFA salt::US9688672, Example 233	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 377					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247631	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247631&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451986	346542171							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472126	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cnc(s2)-c2cccnc2)n1	InChI=1S/C19H19ClN6O3S/c1-10(14-8-22-17(30-14)12-4-3-5-21-7-12)23-18-24-15(20)6-16(25-18)26-13(11(2)27)9-29-19(26)28/h3-8,10-11,13,27H,9H2,1-2H3,(H,23,24,25)/t10-,11+,13+/m0/s1	GWNOCTRCIHVVOY-DMDPSCGWSA-N	247632	US10112931, Example 234::US9434719, 234 as TFA salt::US9688672, Example 234	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 213					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247632	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247632&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451987	346542172							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472127	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cnc(s2)-c2ccncc2)n1	InChI=1S/C19H19ClN6O3S/c1-10(14-8-22-17(30-14)12-3-5-21-6-4-12)23-18-24-15(20)7-16(25-18)26-13(11(2)27)9-29-19(26)28/h3-8,10-11,13,27H,9H2,1-2H3,(H,23,24,25)/t10-,11+,13+/m0/s1	IROXAHIFHVMTEB-DMDPSCGWSA-N	247633	US10112931, Example 235::US9434719, 235 as TFA salt::US9688672, Example 235	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 964					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247633	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247633&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451988	346542173							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472128	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H22ClN5O4/c1-11-8-19(27-17(13(3)28)10-30-21(27)29)25-20(23-11)24-12(2)16-9-18(31-26-16)14-4-6-15(22)7-5-14/h4-9,12-13,17,28H,10H2,1-3H3,(H,23,24,25)/t12-,13+,17+/m0/s1	FPLYMOMTXHDUGW-OGHNNQOOSA-N	247634	US10112931, Example 236::US9434719, 236 as TFA salt::US9688672, Example 236	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 33					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247634	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247634&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269414	346542174							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472129	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H22ClN5O3S/c1-11-8-18(27-16(13(3)28)10-30-21(27)29)26-20(24-11)25-12(2)17-9-23-19(31-17)14-4-6-15(22)7-5-14/h4-9,12-13,16,28H,10H2,1-3H3,(H,24,25,26)/t12-,13+,16+/m0/s1	ZOKITBNIUWKILT-WOSRLPQWSA-N	247635	US10112931, Example 237::US9434719, 237 as TFA salt::US9688672, Example 237	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 22					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247635	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247635&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269415	346542175							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472130	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H23ClN6O3/c1-12-8-19(28-18(14(3)29)10-31-21(28)30)26-20(24-12)25-13(2)17-9-27(11-23-17)16-6-4-15(22)5-7-16/h4-9,11,13-14,18,29H,10H2,1-3H3,(H,24,25,26)/t13-,14+,18+/m0/s1	HECWSALEDFQPTC-PMUMKWKESA-N	247636	US10112931, Example 238::US9434719, 238 as TFA salt::US9688672, Example 238	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 21					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247636	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247636&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269416	346542176							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472131	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2nc(no2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H21ClN6O4/c1-10-8-16(27-15(12(3)28)9-30-20(27)29)24-19(22-10)23-11(2)18-25-17(26-31-18)13-4-6-14(21)7-5-13/h4-8,11-12,15,28H,9H2,1-3H3,(H,22,23,24)/t11-,12+,15+/m0/s1	UFZIIKCLHDLDOA-YWPYICTPSA-N	247637	US10112931, Example 239::US9434719, 239 as TFA salt::US9688672, Example 239	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 54					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247637	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247637&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451991	346542177							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472132	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2ccn(n2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H23ClN6O3/c1-12-10-19(28-18(14(3)29)11-31-21(28)30)25-20(23-12)24-13(2)17-8-9-27(26-17)16-6-4-15(22)5-7-16/h4-10,13-14,18,29H,11H2,1-3H3,(H,23,24,25)/t13-,14+,18+/m0/s1	ZORATSZUVFSTGC-PMUMKWKESA-N	247638	US10112931, Example 240::US9434719, 240 as TFA salt::US9688672, Example 240	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 142					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247638	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247638&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451989	346542178							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472133	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2cn(nn2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H22ClN7O3/c1-11-8-18(28-17(13(3)29)10-31-20(28)30)24-19(22-11)23-12(2)16-9-27(26-25-16)15-6-4-14(21)5-7-15/h4-9,12-13,17,29H,10H2,1-3H3,(H,22,23,24)/t12-,13+,17+/m0/s1	IDFAFGSODHNRAE-OGHNNQOOSA-N	247639	US10112931, Example 241::US9434719, 241 as TFA salt::US9688672, Example 241	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 114					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247639	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247639&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452008	346542179							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472134	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cn(nn2)-c2ccc(Cl)cc2)n1	InChI=1S/C19H19Cl2N7O3/c1-10(14-8-27(26-25-14)13-5-3-12(20)4-6-13)22-18-23-16(21)7-17(24-18)28-15(11(2)29)9-31-19(28)30/h3-8,10-11,15,29H,9H2,1-2H3,(H,22,23,24)/t10-,11+,15+/m0/s1	MVNFRIVYALUSNC-FIXISWKDSA-N	247640	US10112931, Example 242::US9434719, 242 as TFA salt::US9688672, Example 242	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 42					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247640	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247640&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451996	346542180							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472135	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(nn2)-c2ccc(Cl)cc2)n1	InChI=1S/C19H20ClN7O3/c1-11(15-9-26(25-24-15)14-5-3-13(20)4-6-14)22-18-21-8-7-17(23-18)27-16(12(2)28)10-30-19(27)29/h3-9,11-12,16,28H,10H2,1-2H3,(H,21,22,23)/t11-,12+,16+/m0/s1	YMPRBDSLBVYVDN-HWWQOWPSSA-N	247641	US10112931, Example 243::US9434719, 243 as TFA salt::US9688672, Example 243	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 141					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247641	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247641&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452006	346542181							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472136	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2ccc(cc2F)C(C)(F)F)n1	InChI=1S/C20H23F3N4O3/c1-10-7-17(27-16(12(3)28)9-30-19(27)29)26-18(24-10)25-11(2)14-6-5-13(8-15(14)21)20(4,22)23/h5-8,11-12,16,28H,9H2,1-4H3,(H,24,25,26)/t11-,12+,16+/m0/s1	MFKGBSTYHGRYAC-HWWQOWPSSA-N	247642	US10112931, Example 244::US9434719, 244 as TFA salt::US9688672, Example 244	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 300					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247642	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247642&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452007	346542182							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472137	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2cc(F)c(OCC(F)(F)F)cc2F)n1	InChI=1S/C20H21F5N4O4/c1-9-4-17(29-15(11(3)30)7-32-19(29)31)28-18(26-9)27-10(2)12-5-14(22)16(6-13(12)21)33-8-20(23,24)25/h4-6,10-11,15,30H,7-8H2,1-3H3,(H,26,27,28)/t10-,11+,15+/m0/s1	HLWUMVHBOXMUDW-FIXISWKDSA-N	247643	US10112931, Example 245::US9434719, 245 as TFA salt::US9688672, Example 245	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 115					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247643	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247643&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452009	346542183							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472138	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2cnc(s2)-c2ccc(C)nc2)n1	InChI=1S/C21H24N6O3S/c1-11-5-6-15(8-22-11)19-23-9-17(31-19)13(3)25-20-24-12(2)7-18(26-20)27-16(14(4)28)10-30-21(27)29/h5-9,13-14,16,28H,10H2,1-4H3,(H,24,25,26)/t13-,14+,16+/m0/s1	ZJUXDIOBFVYEMM-SQWLQELKSA-N	247644	US10112931, Example 246::US9434719, 246 as TFA salt::US9688672, Example 246	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 273					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247644	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247644&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452001	346542184							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472139	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(nc2)C(F)(F)F)n1	InChI=1S/C20H19F3N6O3S/c1-10(14-8-26-17(33-14)12-3-4-15(25-7-12)20(21,22)23)27-18-24-6-5-16(28-18)29-13(11(2)30)9-32-19(29)31/h3-8,10-11,13,30H,9H2,1-2H3,(H,24,27,28)/t10-,11+,13+/m0/s1	YOXVWMIYZJNANU-DMDPSCGWSA-N	247645	US10112931, Example 247::US9434719, 247 as TFA salt::US9688672, Example 247	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 79					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247645	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247645&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451999	346542185							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472140	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H19F3N6O3S/c1-10(14-8-26-17(33-14)12-3-5-24-15(7-12)20(21,22)23)27-18-25-6-4-16(28-18)29-13(11(2)30)9-32-19(29)31/h3-8,10-11,13,30H,9H2,1-2H3,(H,25,27,28)/t10-,11+,13+/m0/s1	CUGAITRVORLYKS-DMDPSCGWSA-N	247646	US10112931, Example 248::US9434719, 248 as TFA salt::US9688672, Example 248	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 172					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247646	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247646&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451998	346542186							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472141	COC(=O)c1cc(nc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1)N1[C@H](COC1=O)[C@@H](C)O	InChI=1S/C22H22ClN5O5S/c1-11(17-9-24-19(34-17)13-4-6-14(23)7-5-13)25-21-26-15(20(30)32-3)8-18(27-21)28-16(12(2)29)10-33-22(28)31/h4-9,11-12,16,29H,10H2,1-3H3,(H,25,26,27)/t11-,12+,16+/m0/s1	RTOYWSLPXKHJCU-HWWQOWPSSA-N	247647	US10112931, Example 249::US9434719, 249 as TFA salt::US9688672, Example 249	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 635					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247647	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247647&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452000	346542187							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472142	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(c(C)n2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H23ClN6O3/c1-12(17-10-27(14(3)25-17)16-6-4-15(22)5-7-16)24-20-23-9-8-19(26-20)28-18(13(2)29)11-31-21(28)30/h4-10,12-13,18,29H,11H2,1-3H3,(H,23,24,26)/t12-,13+,18+/m0/s1	YPKNXPWEMZFDTH-VEVIJQCQSA-N	247648	US10112931, Example 250::US9434719, 250 as TFA salt::US9688672, Example 250	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 36					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247648	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247648&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452002	346542188							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472143	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(cc2)C(F)F)n1	InChI=1S/C21H21F2N5O3S/c1-11(16-9-25-19(32-16)14-5-3-13(4-6-14)18(22)23)26-20-24-8-7-17(27-20)28-15(12(2)29)10-31-21(28)30/h3-9,11-12,15,18,29H,10H2,1-2H3,(H,24,26,27)/t11-,12+,15+/m0/s1	OZBMOMJUPQEKSW-YWPYICTPSA-N	247649	US10112931, Example 251::US9434719, 251 as TFA salt::US9688672, Example 251	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247649	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247649&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269417	346542189							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472144	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cc2F)C(F)(F)F)n1	InChI=1S/C18H18F4N4O3/c1-9(12-4-3-11(7-13(12)19)18(20,21)22)24-16-23-6-5-15(25-16)26-14(10(2)27)8-29-17(26)28/h3-7,9-10,14,27H,8H2,1-2H3,(H,23,24,25)/t9-,10+,14+/m0/s1	RYHKACMYIHVDLT-IMSIIYSGSA-N	247650	US10112931, Example 252::US9434719, 252 as TFA salt::US9688672, Example 252	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 309					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247650	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247650&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452010	346542190							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472145	CCOC1(CC1)c1ccc([C@H](C)Nc2nccc(n2)N2[C@H](COC2=O)[C@@H](C)O)c(F)c1	InChI=1S/C22H27FN4O4/c1-4-31-22(8-9-22)15-5-6-16(17(23)11-15)13(2)25-20-24-10-7-19(26-20)27-18(14(3)28)12-30-21(27)29/h5-7,10-11,13-14,18,28H,4,8-9,12H2,1-3H3,(H,24,25,26)/t13-,14+,18+/m0/s1	AQYCAWIUYRMHIB-PMUMKWKESA-N	247651	US10112931, Example 253::US9434719, 253 as TFA salt::US9688672, Example 253	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 109					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247651	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247651&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452005	346542191							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472146	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(C(=O)NC3CCCC3)c(Cl)c2)n1	InChI=1S/C23H28ClN5O4/c1-13(15-7-8-17(18(24)11-15)21(31)27-16-5-3-4-6-16)26-22-25-10-9-20(28-22)29-19(14(2)30)12-33-23(29)32/h7-11,13-14,16,19,30H,3-6,12H2,1-2H3,(H,27,31)(H,25,26,28)/t13-,14+,19+/m0/s1	XRZIQGOJIJWMMV-IQUTYRLHSA-N	247652	US10112931, Example 254::US9434719, 254 as TFA salt::US9688672, Example 254	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 234					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247652	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247652&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454395	346542192							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472147	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cc2F)C2(CC2)C#N)n1	InChI=1S/C21H22FN5O3/c1-12(15-4-3-14(9-16(15)22)21(11-23)6-7-21)25-19-24-8-5-18(26-19)27-17(13(2)28)10-30-20(27)29/h3-5,8-9,12-13,17,28H,6-7,10H2,1-2H3,(H,24,25,26)/t12-,13+,17+/m0/s1	QBZLIKUJCVQCBW-OGHNNQOOSA-N	247653	US10112931, Example 255::US9434719, 255 as TFA salt::US9688672, Example 255	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 450					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247653	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247653&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452003	346542193							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472148	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cc2F)-c2cnn(C)c2)n1	InChI=1S/C21H23FN6O3/c1-12(16-5-4-14(8-17(16)22)15-9-24-27(3)10-15)25-20-23-7-6-19(26-20)28-18(13(2)29)11-31-21(28)30/h4-10,12-13,18,29H,11H2,1-3H3,(H,23,25,26)/t12-,13+,18+/m0/s1	GHQLTKCUTUVNJO-VEVIJQCQSA-N	247654	US10112931, Example 256::US9434719, 256 as TFA salt::US9688672, Example 256	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 570					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247654	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247654&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452015	346542194							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472149	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cc2)-c2cnn(C)c2)n1	InChI=1S/C21H24N6O3/c1-13(15-4-6-16(7-5-15)17-10-23-26(3)11-17)24-20-22-9-8-19(25-20)27-18(14(2)28)12-30-21(27)29/h4-11,13-14,18,28H,12H2,1-3H3,(H,22,24,25)/t13-,14+,18+/m0/s1	ZHQOAULHCPIAQO-PMUMKWKESA-N	247655	US10112931, Example 257::US9434719, 257 as TFA salt::US9688672, Example 257	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1200					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247655	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247655&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452017	346542195							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472150	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cc2F)-c2cn[nH]c2)n1			247656	US10112931, Example 258::US9434719, 258 as TFA salt::US9688672, Example 258	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 737					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247656	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247656&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452011	346542196							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472151	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)C(F)(F)F)ncc1F	InChI=1S/C18H17F5N4O3/c1-8(11-4-3-10(5-12(11)19)18(21,22)23)25-16-24-6-13(20)15(26-16)27-14(9(2)28)7-30-17(27)29/h3-6,8-9,14,28H,7H2,1-2H3,(H,24,25,26)/t8-,9+,14+/m0/s1	PEBYCAUAWFUTMN-ATEUNZGCSA-N	247657	US10112931, Example 259::US9434719, 259::US9688672, Example 259	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 105					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247657	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247657&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452004	346542197							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472152	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)C(F)(F)F)ncc1F	InChI=1S/C18H17F5N4O3/c1-8(11-4-3-10(5-12(11)19)18(21,22)23)25-16-24-6-13(20)15(26-16)27-14(9(2)28)7-30-17(27)29/h3-6,8-9,14,28H,7H2,1-2H3,(H,24,25,26)/t8-,9+,14+/m0/s1	PEBYCAUAWFUTMN-ATEUNZGCSA-N	247657	US10112931, Example 259::US9434719, 259::US9688672, Example 259	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 49					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247657	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247657&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452004	346542197							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472153	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cc2F)C2(C)CC2)n1	InChI=1S/C21H25FN4O3/c1-12(15-5-4-14(10-16(15)22)21(3)7-8-21)24-19-23-9-6-18(25-19)26-17(13(2)27)11-29-20(26)28/h4-6,9-10,12-13,17,27H,7-8,11H2,1-3H3,(H,23,24,25)/t12-,13+,17+/m0/s1	IOJOVSUDBXKRLR-OGHNNQOOSA-N	247658	US10112931, Example 260::US9434719, 260 as TFA salt::US9688672, Example 260	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 40					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247658	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247658&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269623	346542198							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472154	CC(C)c1ccc([C@H](C)Nc2nccc(n2)N2[C@H](COC2=O)[C@@H](C)O)c(F)c1	InChI=1S/C20H25FN4O3/c1-11(2)14-5-6-15(16(21)9-14)12(3)23-19-22-8-7-18(24-19)25-17(13(4)26)10-28-20(25)27/h5-9,11-13,17,26H,10H2,1-4H3,(H,22,23,24)/t12-,13+,17+/m0/s1	CDQINWYQTPTUKW-OGHNNQOOSA-N	247659	US10112931, Example 261::US9434719, 261 as TFA salt::US9688672, Example 261	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 64					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247659	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247659&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452012	346542199							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472155	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)-c2cnn(C)c2)ncc1F	InChI=1S/C21H22F2N6O3/c1-11(15-5-4-13(6-16(15)22)14-7-25-28(3)9-14)26-20-24-8-17(23)19(27-20)29-18(12(2)30)10-32-21(29)31/h4-9,11-12,18,30H,10H2,1-3H3,(H,24,26,27)/t11-,12+,18+/m0/s1	TXAUZBVLXHFROM-VNBZBWLYSA-N	247660	US10112931, Example 262::US9434719, 262 as TFA salt::US9688672, Example 262	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 88					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247660	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247660&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118121698	346542200							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472156	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)C2(C)CC2)ncc1F	InChI=1S/C21H24F2N4O3/c1-11(14-5-4-13(8-15(14)22)21(3)6-7-21)25-19-24-9-16(23)18(26-19)27-17(12(2)28)10-30-20(27)29/h4-5,8-9,11-12,17,28H,6-7,10H2,1-3H3,(H,24,25,26)/t11-,12+,17+/m0/s1	MGAMZOLBMBPWEM-XWCIJXRUSA-N	247661	US10112931, Example 263::US9434719, 263 as TFA salt::US9688672, Example 263	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247661	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247661&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452024	346542201							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472157	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)-c2cn[nH]c2)ncc1F			247662	US10112931, Example 264::US9434719, 264 as TFA salt::US9688672, Example 264	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 152					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247662	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247662&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452013	346542202							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472158	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)C(C)(C)O)ncc1F	InChI=1S/C20H24F2N4O4/c1-10(13-6-5-12(7-14(13)21)20(3,4)29)24-18-23-8-15(22)17(25-18)26-16(11(2)27)9-30-19(26)28/h5-8,10-11,16,27,29H,9H2,1-4H3,(H,23,24,25)/t10-,11+,16+/m0/s1	MGUKRKGLGOTAFE-LYOVBCGYSA-N	247664	US10112931, Example 266::US9434719, 266 as TFA salt::US9688672, Example 266	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 453					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247664	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247664&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452016	346542204							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472159	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(F)c(cc2F)-c2cnn(C)c2)ncc1F	InChI=1S/C21H21F3N6O3/c1-10(13-4-16(23)14(5-15(13)22)12-6-26-29(3)8-12)27-20-25-7-17(24)19(28-20)30-18(11(2)31)9-33-21(30)32/h4-8,10-11,18,31H,9H2,1-3H3,(H,25,27,28)/t10-,11+,18+/m0/s1	IOWKGSVTZWXRBF-CSJMPQKXSA-N	247665	US10112931, Example 267::US9434719, 267 as TFA salt::US9688672, Example 267	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 48					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247665	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247665&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452019	346542205							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472160	C[C@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H20ClN5O3S/c1-11(16-9-23-18(30-16)13-3-5-14(21)6-4-13)24-19-22-8-7-17(25-19)26-15(12(2)27)10-29-20(26)28/h3-9,11-12,15,27H,10H2,1-2H3,(H,22,24,25)/t11-,12-,15+/m0/s1	GVHVMKBUEILJFX-SLEUVZQESA-N	247666	US10112931, Example 268::US9434719, 268 as TFA salt::US9688672, Example 268	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 338					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247666	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247666&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414838	346542206							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472161	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(cc2F)C(C)(C)F)n1	InChI=1S/C20H23ClF2N4O3/c1-10(13-6-5-12(7-14(13)22)20(3,4)23)24-18-25-16(21)8-17(26-18)27-15(11(2)28)9-30-19(27)29/h5-8,10-11,15,28H,9H2,1-4H3,(H,24,25,26)/t10-,11+,15+/m0/s1	YUIMGYKEBSSANY-FIXISWKDSA-N	247667	US10112931, Example 269::US9434719, 269::US9688672, Example 269	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 251					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247667	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247667&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452021	346542207							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472162	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)ncc1Cl	InChI=1S/C20H20Cl2N6O3/c1-11(16-8-27(10-24-16)14-5-3-13(21)4-6-14)25-19-23-7-15(22)18(26-19)28-17(12(2)29)9-31-20(28)30/h3-8,10-12,17,29H,9H2,1-2H3,(H,23,25,26)/t11-,12+,17+/m0/s1	MFAIVUGSMBNZNQ-XWCIJXRUSA-N	247668	US10112931, Example 270::US9434719, 270 as TFA salt::US9688672, Example 270	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 174					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247668	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247668&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452018	346542208							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472163	CC(C)c1cc(F)c(cc1F)[C@H](C)Nc1nccc(n1)N1[C@H](COC1=O)C(C)O	InChI=1S/C20H24F2N4O3/c1-10(2)13-7-16(22)14(8-15(13)21)11(3)24-19-23-6-5-18(25-19)26-17(12(4)27)9-29-20(26)28/h5-8,10-12,17,27H,9H2,1-4H3,(H,23,24,25)/t11-,12?,17+/m0/s1	ZGASCMMHPOSBQL-SHECSYJXSA-N	247669	US10112931, Example 271::US9434719, 271 as TFA salt::US9688672, Example 271	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 339					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247669	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247669&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452020	346542209							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472164	CC(O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(Br)cc2F)n1	InChI=1S/C17H17BrF2N4O3/c1-8(10-5-13(20)11(18)6-12(10)19)22-16-21-4-3-15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)/t8-,9?,14+/m0/s1	NPDKKAHJQMWLIK-MCFIVFDNSA-N	247670	US10112931, Example 272::US9434719, 272 as TFA salt::US9688672, Example 272	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 117					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247670	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247670&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452023	346542210							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472165	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Cl)cc2F)ncc1F	InChI=1S/C17H17ClF2N4O3/c1-8(11-4-3-10(18)5-12(11)19)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)/t8-,9+,14+/m0/s1	MIKNJCHRGQEDCS-ATEUNZGCSA-N	247675	US10112931, Example 278::US9434719, 277 as TFA salt::US9434719, 278 as TFA salt::US9688672, Example 278	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 174					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247675	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247675&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452029	346542215							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472166	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ncc(Br)cc2F)ncc1F	InChI=1S/C16H16BrF2N5O3/c1-7(13-10(18)3-9(17)4-20-13)22-15-21-5-11(19)14(23-15)24-12(8(2)25)6-27-16(24)26/h3-5,7-8,12,25H,6H2,1-2H3,(H,21,22,23)/t7-,8+,12+/m0/s1	YTKUKOMQKYDZGC-JOAULVNJSA-N	247677	US10112931, Example 279::US9434719, 279 as TFA salt::US9688672, Example 279	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12700					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247677	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247677&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452030	346542216							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472167	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@H](C)c2ncc(Br)cc2F)ncc1F	InChI=1S/C16H16BrF2N5O3/c1-7(13-10(18)3-9(17)4-20-13)22-15-21-5-11(19)14(23-15)24-12(8(2)25)6-27-16(24)26/h3-5,7-8,12,25H,6H2,1-2H3,(H,21,22,23)/t7-,8-,12-/m1/s1	YTKUKOMQKYDZGC-DNSOKLHBSA-N	247678	US10112931, Example 280::US9434719, 280 as TFA salt::US9688672, Example 280	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3640					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247678	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247678&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452031	346542217							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472168	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2nc(no2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C19H18ClFN6O4/c1-9(17-24-15(26-31-17)11-3-5-12(20)6-4-11)23-18-22-7-13(21)16(25-18)27-14(10(2)28)8-30-19(27)29/h3-7,9-10,14,28H,8H2,1-2H3,(H,22,23,25)/t9-,10+,14+/m0/s1	PESHRRIJDGTOFK-IMSIIYSGSA-N	247679	US10112931, Example 281::US9434719, 281 as TFA salt::US9688672, Example 281	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 26					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247679	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247679&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452032	346542218							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472169	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Br)cn2)ncc1F	InChI=1S/C16H17BrFN5O3/c1-8(12-4-3-10(17)5-19-12)21-15-20-6-11(18)14(22-15)23-13(9(2)24)7-26-16(23)25/h3-6,8-9,13,24H,7H2,1-2H3,(H,20,21,22)/t8-,9+,13+/m0/s1	RBAOXXAHDHLUBH-IGJMFERPSA-N	247680	US10112931, Example 282::US9434719, 282 as TFA salt::US9688672, Example 282	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4270					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247680	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247680&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452034	346542219							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472170	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Br)c(F)c2)ncc1F	InChI=1S/C17H17BrF2N4O3/c1-8(10-3-4-11(18)12(19)5-10)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)/t8-,9+,14+/m0/s1	WTPORLYMZRGTMX-ATEUNZGCSA-N	247681	US10112931, Example 283::US9434719, 283 as TFA salt::US9688672, Example 283	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 68					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247681	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247681&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452035	346542220							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472171	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnc(c(Cl)c2)C(C)(F)F)ncc1F	InChI=1S/C18H19ClF3N5O3/c1-8(10-4-11(19)14(23-5-10)18(3,21)22)25-16-24-6-12(20)15(26-16)27-13(9(2)28)7-30-17(27)29/h4-6,8-9,13,28H,7H2,1-3H3,(H,24,25,26)/t8-,9+,13+/m0/s1	FXEUSGVGTLCLKW-IGJMFERPSA-N	247682	US10112931, Example 284::US9434719, 284 as TFA salt::US9688672, Example 284	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 266					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247682	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247682&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452033	346542221							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472172	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnc(OCC(F)(F)F)c(Cl)c2)ncc1F	InChI=1S/C18H18ClF4N5O4/c1-8(10-3-11(19)15(24-4-10)32-7-18(21,22)23)26-16-25-5-12(20)14(27-16)28-13(9(2)29)6-31-17(28)30/h3-5,8-9,13,29H,6-7H2,1-2H3,(H,25,26,27)/t8-,9+,13+/m0/s1	OGZGYYFXIANBIU-IGJMFERPSA-N	247683	US10112931, Example 285::US9434719, 285 as TFA salt::US9688672, Example 285	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 53					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247683	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247683&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414304	346542222							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472173	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Cl)cc2Cl)ncc1F	InChI=1S/C17H17Cl2FN4O3/c1-8(11-4-3-10(18)5-12(11)19)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)/t8-,9+,14+/m0/s1	CEORPLNBANSUEU-ATEUNZGCSA-N	247684	US10112931, Example 286::US9434719, 286 as TFA salt::US9688672, Example 286	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 36					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247684	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247684&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452036	346542223							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472174	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Br)nc2)ncc1F	InChI=1S/C16H17BrFN5O3/c1-8(10-3-4-13(17)19-5-10)21-15-20-6-11(18)14(22-15)23-12(9(2)24)7-26-16(23)25/h3-6,8-9,12,24H,7H2,1-2H3,(H,20,21,22)/t8-,9+,12+/m0/s1	UQOZSNMDWKOGKY-YGOYTEALSA-N	247685	US10112931, Example 287::US9434719, 287 as TFA salt::US9688672, Example 287	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2250					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247685	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247685&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452037	346542224							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472175	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Cl)c(F)c2)ncc1F	InChI=1S/C17H17ClF2N4O3/c1-8(10-3-4-11(18)12(19)5-10)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)/t8-,9+,14+/m0/s1	IDOWDLBTGMMLQK-ATEUNZGCSA-N	247686	US10112931, Example 288::US9434719, 288 as TFA salt::US9688672, Example 288	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 55					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247686	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247686&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452039	346542225							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472176	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@H](C)c2ccc(Br)cn2)ncc1F	InChI=1S/C16H17BrFN5O3/c1-8(12-4-3-10(17)5-19-12)21-15-20-6-11(18)14(22-15)23-13(9(2)24)7-26-16(23)25/h3-6,8-9,13,24H,7H2,1-2H3,(H,20,21,22)/t8-,9-,13-/m1/s1	RBAOXXAHDHLUBH-JRKPZEMJSA-N	247687	US10112931, Example 289::US9434719, 289 as TFA salt::US9688672, Example 289	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2110					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247687	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247687&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452038	346542226							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472177	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Cl)c(Cl)c2)ncc1F	InChI=1S/C17H17Cl2FN4O3/c1-8(10-3-4-11(18)12(19)5-10)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)/t8-,9+,14+/m0/s1	WFOPXBRBZHRGKH-ATEUNZGCSA-N	247688	US10112931, Example 290::US9434719, 290 as TFA salt::US9688672, Example 290	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 34					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247688	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247688&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452046	346542227							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472178	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnc(Cl)c(F)c2)ncc1F	InChI=1S/C16H16ClF2N5O3/c1-7(9-3-10(18)13(17)20-4-9)22-15-21-5-11(19)14(23-15)24-12(8(2)25)6-27-16(24)26/h3-5,7-8,12,25H,6H2,1-2H3,(H,21,22,23)/t7-,8+,12+/m0/s1	KFYDKIZAFGPBDT-JOAULVNJSA-N	247689	US10112931, Example 291::US9434719, 291::US9688672, Example 291	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247689	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247689&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452040	346542228							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472179	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnc(Cl)c(Cl)c2)ncc1F	InChI=1S/C16H16Cl2FN5O3/c1-7(9-3-10(17)13(18)20-4-9)22-15-21-5-11(19)14(23-15)24-12(8(2)25)6-27-16(24)26/h3-5,7-8,12,25H,6H2,1-2H3,(H,21,22,23)/t7-,8+,12+/m0/s1	JRULGSSMSCVTFJ-JOAULVNJSA-N	247690	US10112931, Example 292::US9434719, 292::US9688672, Example 292	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1850					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247690	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247690&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452041	346542229							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472180	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@H](C)c2ncc(Cl)cc2Cl)ncc1F	InChI=1S/C16H16Cl2FN5O3/c1-7(13-10(18)3-9(17)4-20-13)22-15-21-5-11(19)14(23-15)24-12(8(2)25)6-27-16(24)26/h3-5,7-8,12,25H,6H2,1-2H3,(H,21,22,23)/t7-,8-,12-/m1/s1	DWCICAAUBMNBFX-DNSOKLHBSA-N	247691	US10112931, Example 293::US9434719, 293::US9688672, Example 293	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>7910					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247691	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247691&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452042	346542230							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472181	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ncc(Cl)cc2Cl)ncc1F	InChI=1S/C16H16Cl2FN5O3/c1-7(13-10(18)3-9(17)4-20-13)22-15-21-5-11(19)14(23-15)24-12(8(2)25)6-27-16(24)26/h3-5,7-8,12,25H,6H2,1-2H3,(H,21,22,23)/t7-,8+,12+/m0/s1	DWCICAAUBMNBFX-JOAULVNJSA-N	247692	US10112931, Example 294::US9434719, 294::US9688672, Example 294	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 466					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247692	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247692&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452045	346542231							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472182	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ncc(Cl)cc2Cl)n1	InChI=1S/C16H16Cl3N5O3/c1-7(14-10(18)3-9(17)5-20-14)21-15-22-12(19)4-13(23-15)24-11(8(2)25)6-27-16(24)26/h3-5,7-8,11,25H,6H2,1-2H3,(H,21,22,23)/t7-,8+,11+/m0/s1	AGPUBPGXSXBHPI-VAOFZXAKSA-N	247693	US10112931, Example 295::US9434719, 295::US9688672, Example 295	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247693	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247693&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452043	346542232							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472183	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ncc(OCC(F)(F)F)cc2F)n1	InChI=1S/C18H18ClF4N5O4/c1-8(15-11(20)3-10(5-24-15)32-7-18(21,22)23)25-16-26-13(19)4-14(27-16)28-12(9(2)29)6-31-17(28)30/h3-5,8-9,12,29H,6-7H2,1-2H3,(H,25,26,27)/t8-,9+,12+/m0/s1	FJIZBPDEWHMTDE-YGOYTEALSA-N	247694	US10112931, Example 296::US9434719, 296::US9688672, Example 296	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 251					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247694	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247694&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452044	346542233							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472184	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@H](C)c2ccn(n2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C20H20ClFN6O3/c1-11(16-7-8-27(26-16)14-5-3-13(21)4-6-14)24-19-23-9-15(22)18(25-19)28-17(12(2)29)10-31-20(28)30/h3-9,11-12,17,29H,10H2,1-2H3,(H,23,24,25)/t11-,12-,17-/m1/s1	RWUSZRWKGUZDBQ-PSTGCABASA-N	247695	US10112931, Example 297::US9434719, 297::US9688672, Example 297	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2960					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247695	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247695&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452047	346542234							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472185	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccn(n2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C20H20ClFN6O3/c1-11(16-7-8-27(26-16)14-5-3-13(21)4-6-14)24-19-23-9-15(22)18(25-19)28-17(12(2)29)10-31-20(28)30/h3-9,11-12,17,29H,10H2,1-2H3,(H,23,24,25)/t11-,12+,17+/m0/s1	RWUSZRWKGUZDBQ-XWCIJXRUSA-N	247696	US10112931, Example 298::US9434719, 298::US9688672, Example 298	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247696	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247696&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452048	346542235							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472186	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@H](C)c2cn(cn2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C20H20ClFN6O3/c1-11(16-8-27(10-24-16)14-5-3-13(21)4-6-14)25-19-23-7-15(22)18(26-19)28-17(12(2)29)9-31-20(28)30/h3-8,10-12,17,29H,9H2,1-2H3,(H,23,25,26)/t11-,12-,17-/m1/s1	GREBTMQANDUXHS-PSTGCABASA-N	247697	US10112931, Example 299::US9434719, 299::US9688672, Example 299	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 457					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247697	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247697&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452050	346542236							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472187	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C20H20ClFN6O3/c1-11(16-8-27(10-24-16)14-5-3-13(21)4-6-14)25-19-23-7-15(22)18(26-19)28-17(12(2)29)9-31-20(28)30/h3-8,10-12,17,29H,9H2,1-2H3,(H,23,25,26)/t11-,12+,17+/m0/s1	GREBTMQANDUXHS-XWCIJXRUSA-N	247698	US10112931, Example 300::US9434719, 300::US9688672, Example 300	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10.00					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247698	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247698&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452052	346542237							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472188	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(F)c(OCC(F)(F)F)cc2F)ncc1F	InChI=1S/C19H18F6N4O4/c1-8(10-3-12(21)15(4-11(10)20)33-7-19(23,24)25)27-17-26-5-13(22)16(28-17)29-14(9(2)30)6-32-18(29)31/h3-5,8-9,14,30H,6-7H2,1-2H3,(H,26,27,28)/t8-,9+,14+/m0/s1	YZZWVWNMONRDBU-ATEUNZGCSA-N	247699	US10112931, Example 301::US9434719, 301::US9688672, Example 301	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 21					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247699	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247699&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452051	346542238							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472189	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OCC(F)(F)F)cc2F)ncc1F	InChI=1S/C19H19F5N4O4/c1-9(12-4-3-11(5-13(12)20)32-8-19(22,23)24)26-17-25-6-14(21)16(27-17)28-15(10(2)29)7-31-18(28)30/h3-6,9-10,15,29H,7-8H2,1-2H3,(H,25,26,27)/t9-,10+,15+/m0/s1	LFTKBFBHPUUCMO-FEUHOPSXSA-N	247700	US10112931, Example 302::US9434719, 302::US9688672, Example 302	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 45					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247700	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247700&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452049	346542239							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472190	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OCC(F)(F)F)c(F)c2)ncc1F	InChI=1S/C19H19F5N4O4/c1-9(11-3-4-15(12(20)5-11)32-8-19(22,23)24)26-17-25-6-13(21)16(27-17)28-14(10(2)29)7-31-18(28)30/h3-6,9-10,14,29H,7-8H2,1-2H3,(H,25,26,27)/t9-,10+,14+/m0/s1	WVFOOPQGQMFLTC-IMSIIYSGSA-N	247701	US10112931, Example 303::US9434719, 303::US9688672, Example 303	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 9.00					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247701	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247701&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452053	346542240							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472191	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccn(n2)-c2ccc(F)cc2)ncc1F	InChI=1S/C20H20F2N6O3/c1-11(16-7-8-27(26-16)14-5-3-13(21)4-6-14)24-19-23-9-15(22)18(25-19)28-17(12(2)29)10-31-20(28)30/h3-9,11-12,17,29H,10H2,1-2H3,(H,23,24,25)/t11-,12+,17+/m0/s1	WTONQGGHWHWAFG-XWCIJXRUSA-N	247702	US10112931, Example 304::US9434719, 304::US9688672, Example 304	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 304					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247702	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247702&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452056	346542241							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472192	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OCC(F)(F)F)cn2)ncc1F	InChI=1S/C18H19F4N5O4/c1-9(13-4-3-11(5-23-13)31-8-18(20,21)22)25-16-24-6-12(19)15(26-16)27-14(10(2)28)7-30-17(27)29/h3-6,9-10,14,28H,7-8H2,1-2H3,(H,24,25,26)/t9-,10+,14+/m0/s1	BDQMYRKYRKFFNS-IMSIIYSGSA-N	247703	US10112931, Example 305::US9434719, 305::US9688672, Example 305	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 968					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247703	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247703&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452055	346542242							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472193	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@H](C)c2ccc(OCC(F)(F)F)cn2)ncc1F	InChI=1S/C18H19F4N5O4/c1-9(13-4-3-11(5-23-13)31-8-18(20,21)22)25-16-24-6-12(19)15(26-16)27-14(10(2)28)7-30-17(27)29/h3-6,9-10,14,28H,7-8H2,1-2H3,(H,24,25,26)/t9-,10-,14-/m1/s1	BDQMYRKYRKFFNS-GPCCPHFNSA-N	247704	US10112931, Example 306::US9434719, 306::US9688672, Example 306	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2570					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247704	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247704&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452054	346542243							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472194	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H21ClN6O3/c1-12(16-9-26(11-23-16)15-5-3-14(21)4-6-15)24-19-22-8-7-18(25-19)27-17(13(2)28)10-30-20(27)29/h3-9,11-13,17,28H,10H2,1-2H3,(H,22,24,25)/t12-,13+,17+/m0/s1	YFYRVKRJXKSDNY-OGHNNQOOSA-N	247705	US10112931, Example 307::US9434719, 307 as TFA salt::US9688672, Example 307	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 39					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247705	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247705&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90413907	346542244							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472195	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccn(n2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H21ClN6O3/c1-12(16-8-10-26(25-16)15-5-3-14(21)4-6-15)23-19-22-9-7-18(24-19)27-17(13(2)28)11-30-20(27)29/h3-10,12-13,17,28H,11H2,1-2H3,(H,22,23,24)/t12-,13+,17+/m0/s1	KVRCKPJAUVKNSX-OGHNNQOOSA-N	247706	US10112931, Example 308::US9434719, 308 as TFA salt::US9688672, Example 308	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 73					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247706	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247706&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118121699	346542245							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472196	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H20Cl2N6O3/c1-11(15-8-27(10-23-15)14-5-3-13(21)4-6-14)24-19-25-17(22)7-18(26-19)28-16(12(2)29)9-31-20(28)30/h3-8,10-12,16,29H,9H2,1-2H3,(H,24,25,26)/t11-,12+,16+/m0/s1	OYVVZWSDLVZFTI-HWWQOWPSSA-N	247707	US10112931, Example 309::US9434719, 309::US9688672, Example 309	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3.00					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247707	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247707&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			85470932	346542246							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472197	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H20Cl2N6O3/c1-11(15-8-27(10-23-15)14-5-3-13(21)4-6-14)24-19-25-17(22)7-18(26-19)28-16(12(2)29)9-31-20(28)30/h3-8,10-12,16,29H,9H2,1-2H3,(H,24,25,26)/t11-,12+,16+/m0/s1	OYVVZWSDLVZFTI-HWWQOWPSSA-N	247707	US10112931, Example 309::US9434719, 309::US9688672, Example 309	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3.00					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247707	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247707&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			85470932	346542246							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472198	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccn(n2)-c2ccc(F)cc2)n1	InChI=1S/C20H20ClFN6O3/c1-11(15-7-8-27(26-15)14-5-3-13(22)4-6-14)23-19-24-17(21)9-18(25-19)28-16(12(2)29)10-31-20(28)30/h3-9,11-12,16,29H,10H2,1-2H3,(H,23,24,25)/t11-,12+,16+/m0/s1	FSZZEMMBYJPKMX-HWWQOWPSSA-N	247708	US10112931, Example 310::US9434719, 310 as TFA salt::US9688672, Example 310	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 72					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247708	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247708&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118121688	346542247							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472199	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(Cl)cc2Cl)n1	InChI=1S/C17H18Cl2N4O3/c1-9(12-4-3-11(18)7-13(12)19)21-16-20-6-5-15(22-16)23-14(10(2)24)8-26-17(23)25/h3-7,9-10,14,24H,8H2,1-2H3,(H,20,21,22)/t9-,10+,14+/m0/s1	ZGKFKVBNBLHBED-IMSIIYSGSA-N	247709	US10112931, Example 311::US9434719, 311 as TFA salt::US9688672, Example 311	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 518					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247709	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247709&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452059	346542248							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472200	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(Cl)c(Cl)c2)n1	InChI=1S/C17H18Cl2N4O3/c1-9(11-3-4-12(18)13(19)7-11)21-16-20-6-5-15(22-16)23-14(10(2)24)8-26-17(23)25/h3-7,9-10,14,24H,8H2,1-2H3,(H,20,21,22)/t9-,10+,14+/m0/s1	NLZRXHNICGFSSB-IMSIIYSGSA-N	247710	US10112931, Example 312::US9434719, 312 as TFA salt::US9688672, Example 312	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 66					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247710	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247710&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452058	346542249							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472201	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccn(n2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H20Cl2N6O3/c1-11(15-7-8-27(26-15)14-5-3-13(21)4-6-14)23-19-24-17(22)9-18(25-19)28-16(12(2)29)10-31-20(28)30/h3-9,11-12,16,29H,10H2,1-2H3,(H,23,24,25)/t11-,12+,16+/m0/s1	RHVLPDFZYSXTKH-HWWQOWPSSA-N	247711	US10112931, Example 313::US9434719, 313 as TFA salt::US9688672, Example 313	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247711	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247711&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118121710	346542250							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472202	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(OCC(F)(F)F)cc2F)n1	InChI=1S/C19H19F5N4O4/c1-9(11-5-13(21)15(6-12(11)20)32-8-19(22,23)24)26-17-25-4-3-16(27-17)28-14(10(2)29)7-31-18(28)30/h3-6,9-10,14,29H,7-8H2,1-2H3,(H,25,26,27)/t9-,10+,14+/m0/s1	AIKWSLRSPJRXMX-IMSIIYSGSA-N	247712	US10112931, Example 314::US9434719, 314 as TFA salt::US9688672, Example 314	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 113					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247712	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247712&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452061	346542251							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472203	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OCC(F)(F)F)cc2F)n1	InChI=1S/C19H20F4N4O4/c1-10(13-4-3-12(7-14(13)20)31-9-19(21,22)23)25-17-24-6-5-16(26-17)27-15(11(2)28)8-30-18(27)29/h3-7,10-11,15,28H,8-9H2,1-2H3,(H,24,25,26)/t10-,11+,15+/m0/s1	JOAMIQUKLNKTDJ-FIXISWKDSA-N	247713	US10112931, Example 315::US9434719, 315 as TFA salt::US9688672, Example 315	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 338					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247713	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247713&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452069	346542252							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472204	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OCC(F)(F)F)c(F)c2)n1	InChI=1S/C19H20F4N4O4/c1-10(12-3-4-15(13(20)7-12)31-9-19(21,22)23)25-17-24-6-5-16(26-17)27-14(11(2)28)8-30-18(27)29/h3-7,10-11,14,28H,8-9H2,1-2H3,(H,24,25,26)/t10-,11+,14+/m0/s1	BLTGWFIGQAUGPI-MISXGVKJSA-N	247714	US10112931, Example 316::US9434719, 316 as TFA salt::US9688672, Example 316	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 206					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247714	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247714&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452060	346542253							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472205	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(Br)cn2)n1	InChI=1S/C16H18BrN5O3/c1-9(12-4-3-11(17)7-19-12)20-15-18-6-5-14(21-15)22-13(10(2)23)8-25-16(22)24/h3-7,9-10,13,23H,8H2,1-2H3,(H,18,20,21)/t9-,10+,13+/m0/s1	PUDVPUCKGIGHBC-OPQQBVKSSA-N	247715	US10112931, Example 317::US9434719, 317 as TFA salt::US9688672, Example 317	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4665					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247715	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247715&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452065	346542254							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472206	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@H](C)c2ccc(Br)cn2)n1	InChI=1S/C16H18BrN5O3/c1-9(12-4-3-11(17)7-19-12)20-15-18-6-5-14(21-15)22-13(10(2)23)8-25-16(22)24/h3-7,9-10,13,23H,8H2,1-2H3,(H,18,20,21)/t9-,10-,13-/m1/s1	PUDVPUCKGIGHBC-GIPNMCIBSA-N	247716	US10112931, Example 318::US9434719, 318 as TFA salt::US9688672, Example 318	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247716	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247716&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452067	346542255							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472207	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(Cl)c(Cl)cc2F)n1	InChI=1S/C17H17Cl2FN4O3/c1-8(10-5-11(18)12(19)6-13(10)20)22-16-21-4-3-15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)/t8-,9+,14+/m0/s1	MQSONJGUBHNIMZ-ATEUNZGCSA-N	247717	US10112931, Example 319::US9434719, 319 as TFA salt::US9688672, Example 319	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 35					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247717	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247717&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452062	346542256							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472208	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-n2cnc(C)c2)n1	InChI=1S/C21H22F2N6O3/c1-11-8-28(10-25-11)17-7-15(22)14(6-16(17)23)12(2)26-20-24-5-4-19(27-20)29-18(13(3)30)9-32-21(29)31/h4-8,10,12-13,18,30H,9H2,1-3H3,(H,24,26,27)/t12-,13+,18+/m0/s1	NUNXMAPPGUYGGL-VEVIJQCQSA-N	247718	US10112931, Example 320::US9434719, 320 as TFA salt::US9688672, Example 320	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 426					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247718	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247718&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118121700	346542257							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472209	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(Cl)c(cc2F)-n2cnc(C)c2)n1	InChI=1S/C21H22ClFN6O3/c1-11-8-28(10-25-11)17-7-16(23)14(6-15(17)22)12(2)26-20-24-5-4-19(27-20)29-18(13(3)30)9-32-21(29)31/h4-8,10,12-13,18,30H,9H2,1-3H3,(H,24,26,27)/t12-,13+,18+/m0/s1	STJRILYULWTXJS-VEVIJQCQSA-N	175541	US9688672, Example 321	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 13					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175541	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175541&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			133081638	363892397							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472210	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-c2ccnc(C)c2)n1	InChI=1S/C23H23F2N5O3/c1-12-8-15(4-6-26-12)17-10-18(24)16(9-19(17)25)13(2)28-22-27-7-5-21(29-22)30-20(14(3)31)11-33-23(30)32/h4-10,13-14,20,31H,11H2,1-3H3,(H,27,28,29)/t13-,14+,20+/m0/s1	MIZZAXMUDXGBTL-LRDNONRASA-N	247719	US10112931, Example 322::US9434719, 322 as TFA salt::US9688672, Example 322	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 71					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247719	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247719&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268803	346542258							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472211	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-c2ccc(C)nc2)n1	InChI=1S/C23H23F2N5O3/c1-12-4-5-15(10-27-12)17-9-18(24)16(8-19(17)25)13(2)28-22-26-7-6-21(29-22)30-20(14(3)31)11-33-23(30)32/h4-10,13-14,20,31H,11H2,1-3H3,(H,26,28,29)/t13-,14+,20+/m0/s1	CBMZECRSIJOBEO-LRDNONRASA-N	247720	US10112931, Example 323::US9434719, 323 as TFA salt::US9688672, Example 323	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 97					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247720	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247720&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452068	346542259							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472212	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-c2ccnc(c2)C(F)(F)F)n1	InChI=1S/C23H20F5N5O3/c1-11(31-21-30-6-4-20(32-21)33-18(12(2)34)10-36-22(33)35)14-8-17(25)15(9-16(14)24)13-3-5-29-19(7-13)23(26,27)28/h3-9,11-12,18,34H,10H2,1-2H3,(H,30,31,32)/t11-,12+,18+/m0/s1	DZFQRZNEFQNGMD-VNBZBWLYSA-N	247721	US10112931, Example 324::US9434719, 324 as TFA salt::US9688672, Example 324	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 30					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247721	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247721&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452066	346542260							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472213	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-c2ccc(nc2)C(F)(F)F)n1	InChI=1S/C23H20F5N5O3/c1-11(31-21-29-6-5-20(32-21)33-18(12(2)34)10-36-22(33)35)14-7-17(25)15(8-16(14)24)13-3-4-19(30-9-13)23(26,27)28/h3-9,11-12,18,34H,10H2,1-2H3,(H,29,31,32)/t11-,12+,18+/m0/s1	DZGGVPVGJLJAFA-VNBZBWLYSA-N	247722	US10112931, Example 325::US9434719, 325 as TFA salt::US9688672, Example 325	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 41					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247722	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247722&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452070	346542261							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472214	CC(C)COc1ccc(cc1)[C@H](C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O	InChI=1S/C21H28N4O4/c1-13(2)11-28-17-7-5-16(6-8-17)14(3)23-20-22-10-9-19(24-20)25-18(15(4)26)12-29-21(25)27/h5-10,13-15,18,26H,11-12H2,1-4H3,(H,22,23,24)/t14-,15+,18+/m0/s1	BNQMHZZWBOBODR-HDMKZQKVSA-N	247723	US10112931, Example 326::US9434719, 326 as TFA salt::US9688672, Example 326	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 63					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247723	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247723&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454331	346542262							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472215	COc1ccc([C@H](C)Nc2ncc(F)c(n2)N2[C@H](COC2=O)[C@@H](C)O)c(F)c1	InChI=1S/C18H20F2N4O4/c1-9(12-5-4-11(27-3)6-13(12)19)22-17-21-7-14(20)16(23-17)24-15(10(2)25)8-28-18(24)26/h4-7,9-10,15,25H,8H2,1-3H3,(H,21,22,23)/t9-,10+,15+/m0/s1	DQUGIFZLFAYLDQ-FEUHOPSXSA-N	247724	US10112931, Example 327::US9434719, 327 as TFA salt::US9688672, Example 327	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 236					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247724	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247724&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454305	346542263							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472216	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cccc(F)c2F)n1	InChI=1S/C17H18F2N4O3/c1-9(11-4-3-5-12(18)15(11)19)21-16-20-7-6-14(22-16)23-13(10(2)24)8-26-17(23)25/h3-7,9-10,13,24H,8H2,1-2H3,(H,20,21,22)/t9-,10+,13+/m0/s1	FWULJMBJDVDQPS-OPQQBVKSSA-N	247725	US10112931, Example 328::US9434719, 328 as TFA salt::US9688672, Example 328	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1800					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247725	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247725&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454410	346542264							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472217	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cccc(F)c2F)ncc1F	InChI=1S/C17H17F3N4O3/c1-8(10-4-3-5-11(18)14(10)20)22-16-21-6-12(19)15(23-16)24-13(9(2)25)7-27-17(24)26/h3-6,8-9,13,25H,7H2,1-2H3,(H,21,22,23)/t8-,9+,13+/m0/s1	JJBVNJOXQQKWHK-IGJMFERPSA-N	247726	US10112931, Example 329::US9434719, 329 as TFA salt::US9688672, Example 329	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 863					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247726	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247726&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454413	346542265							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472218	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(F)c(F)c2)ncc1F	InChI=1S/C17H17F3N4O3/c1-8(10-3-4-11(18)12(19)5-10)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)/t8-,9+,14+/m0/s1	WAPMSDNNNKZXNB-ATEUNZGCSA-N	247727	US10112931, Example 330::US9434719, 330 as TFA salt::US9688672, Example 330	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 268					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247727	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247727&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454308	346542266							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472219	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(F)cc2F)ncc1F	InChI=1S/C17H17F3N4O3/c1-8(11-4-3-10(18)5-12(11)19)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)/t8-,9+,14+/m0/s1	FGUKTBUGWSRXPO-ATEUNZGCSA-N	247728	US10112931, Example 331::US9434719, 331 as TFA salt::US9688672, Example 331	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 190					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247728	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247728&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454306	346542267							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472220	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(F)cc(F)c2)ncc1F	InChI=1S/C17H17F3N4O3/c1-8(10-3-11(18)5-12(19)4-10)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)/t8-,9+,14+/m0/s1	GJCKVKJRXJEBFW-ATEUNZGCSA-N	247729	US10112931, Example 332::US9434719, 332 as TFA salt::US9688672, Example 332	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1020					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247729	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247729&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454412	346542268							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472221	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ncc(cn2)-c2ccnc(c2)C(F)(F)F)ncc1Cl	InChI=1S/C21H19ClF3N7O3/c1-10(17-27-6-13(7-28-17)12-3-4-26-16(5-12)21(23,24)25)30-19-29-8-14(22)18(31-19)32-15(11(2)33)9-35-20(32)34/h3-8,10-11,15,33H,9H2,1-2H3,(H,29,30,31)/t10-,11+,15+/m0/s1	SJEQFJFYRZCISY-FIXISWKDSA-N	247730	US10112931, Example 333::US9434719, 333 as TFA salt::US9688672, Example 333	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 944					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247730	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247730&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454437	346542269							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472222	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OCC(F)(F)F)nc2)ncc1F	InChI=1S/C18H19F4N5O4/c1-9(11-3-4-14(23-5-11)31-8-18(20,21)22)25-16-24-6-12(19)15(26-16)27-13(10(2)28)7-30-17(27)29/h3-6,9-10,13,28H,7-8H2,1-2H3,(H,24,25,26)/t9-,10+,13+/m0/s1	OEGBQUWOHADSRG-OPQQBVKSSA-N	247731	US10112931, Example 334::US9434719, 334 as TFA salt::US9688672, Example 334	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 341					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247731	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247731&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90417127	346542270							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472223	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)C(F)F)ncc1F	InChI=1S/C18H18F4N4O3/c1-8(11-4-3-10(15(21)22)5-12(11)19)24-17-23-6-13(20)16(25-17)26-14(9(2)27)7-29-18(26)28/h3-6,8-9,14-15,27H,7H2,1-2H3,(H,23,24,25)/t8-,9+,14+/m0/s1	TYNNDJIMSFTUKJ-ATEUNZGCSA-N	247732	US10112931, Example 335::US9434719, 335 as TFA salt::US9688672, Example 335	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 257					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247732	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247732&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414384	346542271							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472224	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)C(C)(F)F)ncc1F	InChI=1S/C19H20F4N4O3/c1-9(12-5-4-11(6-13(12)20)19(3,22)23)25-17-24-7-14(21)16(26-17)27-15(10(2)28)8-30-18(27)29/h4-7,9-10,15,28H,8H2,1-3H3,(H,24,25,26)/t9-,10+,15+/m0/s1	FXGBDOOFJISKMB-FEUHOPSXSA-N	247733	US10112931, Example 336::US9434719, 336::US9688672, Example 336	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 35					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247733	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247733&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414216	346542272							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472225	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)C(C)(F)F)ncc1F	InChI=1S/C19H20F4N4O3/c1-9(12-5-4-11(6-13(12)20)19(3,22)23)25-17-24-7-14(21)16(26-17)27-15(10(2)28)8-30-18(27)29/h4-7,9-10,15,28H,8H2,1-3H3,(H,24,25,26)/t9-,10+,15+/m0/s1	FXGBDOOFJISKMB-FEUHOPSXSA-N	247733	US10112931, Example 336::US9434719, 336::US9688672, Example 336	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 27					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247733	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247733&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414216	346542272							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472226	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(cc2F)C(F)F)n1	InChI=1S/C18H18ClF3N4O3/c1-8(11-4-3-10(16(21)22)5-12(11)20)23-17-24-14(19)6-15(25-17)26-13(9(2)27)7-29-18(26)28/h3-6,8-9,13,16,27H,7H2,1-2H3,(H,23,24,25)/t8-,9+,13+/m0/s1	GWDKSDYMGHXQMI-IGJMFERPSA-N	175572	US10112931, Example 337::US9688672, Example 337	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 313					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175572	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175572&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415594	363892413							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472227	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(cc2F)C(C)(F)F)n1	InChI=1S/C19H20ClF3N4O3/c1-9(12-5-4-11(6-13(12)21)19(3,22)23)24-17-25-15(20)7-16(26-17)27-14(10(2)28)8-30-18(27)29/h4-7,9-10,14,28H,8H2,1-3H3,(H,24,25,26)/t9-,10+,14+/m0/s1	JKPMOPSJPVARMR-IMSIIYSGSA-N	175573	US10112931, Example 338::US9688672, Example 338	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 91					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175573	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175573&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415070	363892414							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472228	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(s2)-c2ccccc2)n1	InChI=1S/C21H21ClN4O3S/c1-12(16-8-9-17(30-16)14-6-4-3-5-7-14)23-20-24-18(22)10-19(25-20)26-15(13(2)27)11-29-21(26)28/h3-10,12-13,15,27H,11H2,1-2H3,(H,23,24,25)/t12-,13+,15+/m0/s1	LOJDRZQZYPCFHT-GZBFAFLISA-N	247736	US10112931, Example 339::US9434719, 339 as TFA salt::US9688672, Example 339	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247736	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247736&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416664	346542275							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472229	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(s2)-c2ccccn2)n1	InChI=1S/C20H20ClN5O3S/c1-11(15-6-7-16(30-15)13-5-3-4-8-22-13)23-19-24-17(21)9-18(25-19)26-14(12(2)27)10-29-20(26)28/h3-9,11-12,14,27H,10H2,1-2H3,(H,23,24,25)/t11-,12+,14+/m0/s1	MIPXSCOEYZXMHU-OUCADQQQSA-N	247737	US10112931, Example 340::US9434719, 340 as TFA salt::US9688672, Example 340	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 61					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247737	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247737&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90417102	346542276							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472230	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cccc(O[C@H]3CCOC3)c2)n1	InChI=1S/C21H26N4O5/c1-13(15-4-3-5-16(10-15)30-17-7-9-28-11-17)23-20-22-8-6-19(24-20)25-18(14(2)26)12-29-21(25)27/h3-6,8,10,13-14,17-18,26H,7,9,11-12H2,1-2H3,(H,22,23,24)/t13-,14+,17-,18+/m0/s1	GGQKMNMZJGIESS-IHETXDGRSA-N	247738	US10112931, Example 341::US9434719, 341 as TFA salt::US9688672, Example 341	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7050					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247738	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247738&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414484	346542277							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472231	CC(C)COc1cccc(c1)[C@H](C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O	InChI=1S/C21H28N4O4/c1-13(2)11-28-17-7-5-6-16(10-17)14(3)23-20-22-9-8-19(24-20)25-18(15(4)26)12-29-21(25)27/h5-10,13-15,18,26H,11-12H2,1-4H3,(H,22,23,24)/t14-,15+,18+/m0/s1	HBTZBVJYHABTQW-HDMKZQKVSA-N	247739	US10112931, Example 342::US9434719, 342 as TFA salt::US9688672, Example 342	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 465					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247739	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247739&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454416	346542278							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472232	CC(C)CS(=O)(=O)c1ccc(cc1)[C@H](C)Nc1nc(Cl)cc(n1)N1[C@H](COC1=O)[C@@H](C)O	InChI=1S/C21H27ClN4O5S/c1-12(2)11-32(29,30)16-7-5-15(6-8-16)13(3)23-20-24-18(22)9-19(25-20)26-17(14(4)27)10-31-21(26)28/h5-9,12-14,17,27H,10-11H2,1-4H3,(H,23,24,25)/t13-,14+,17+/m0/s1	VSYICTLIYPIIPO-JJRVBVJISA-N	247740	US10112931, Example 343::US9434719, 343 as TFA salt::US9688672, Example 343	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 73					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247740	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247740&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454445	346542279							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472233	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OC(F)(F)F)cc2)n1	InChI=1S/C18H19F3N4O4/c1-10(12-3-5-13(6-4-12)29-18(19,20)21)23-16-22-8-7-15(24-16)25-14(11(2)26)9-28-17(25)27/h3-8,10-11,14,26H,9H2,1-2H3,(H,22,23,24)/t10-,11+,14+/m0/s1	MBCIKYUWMXLUQE-MISXGVKJSA-N	247741	US10112931, Example 344::US9434719, 344 as TFA salt::US9688672, Example 344	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 190					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247741	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247741&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454417	346542280							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472234	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OC(F)(F)F)c(F)c2)n1	InChI=1S/C18H18F4N4O4/c1-9(11-3-4-14(12(19)7-11)30-18(20,21)22)24-16-23-6-5-15(25-16)26-13(10(2)27)8-29-17(26)28/h3-7,9-10,13,27H,8H2,1-2H3,(H,23,24,25)/t9-,10+,13+/m0/s1	ANLABPQVTMIFQY-OPQQBVKSSA-N	247742	US10112931, Example 345::US9434719, 345 as TFA salt::US9688672, Example 345	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 201					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247742	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247742&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454309	346542281							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472235	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OC(F)(F)F)cc2F)n1	InChI=1S/C18H18F4N4O4/c1-9(12-4-3-11(7-13(12)19)30-18(20,21)22)24-16-23-6-5-15(25-16)26-14(10(2)27)8-29-17(26)28/h3-7,9-10,14,27H,8H2,1-2H3,(H,23,24,25)/t9-,10+,14+/m0/s1	KPRPSTUXEKHBOA-IMSIIYSGSA-N	247743	US10112931, Example 346::US9434719, 346 as TFA salt::US9688672, Example 346	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 189					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247743	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247743&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454353	346542282							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472236	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OC(F)F)c(F)c2)n1	InChI=1S/C18H19F3N4O4/c1-9(11-3-4-14(12(19)7-11)29-16(20)21)23-17-22-6-5-15(24-17)25-13(10(2)26)8-28-18(25)27/h3-7,9-10,13,16,26H,8H2,1-2H3,(H,22,23,24)/t9-,10+,13+/m0/s1	DYUBLOOWSLOZII-OPQQBVKSSA-N	247744	US10112931, Example 347::US9434719, 347 as TFA salt::US9688672, Example 347	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 395					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247744	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247744&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454441	346542283							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472237	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OC(F)F)c(F)c2)ncc1F	InChI=1S/C18H18F4N4O4/c1-8(10-3-4-14(11(19)5-10)30-16(21)22)24-17-23-6-12(20)15(25-17)26-13(9(2)27)7-29-18(26)28/h3-6,8-9,13,16,27H,7H2,1-2H3,(H,23,24,25)/t8-,9+,13+/m0/s1	KPAIFCRBNKBGFW-IGJMFERPSA-N	247745	US10112931, Example 348::US9434719, 348 as TFA salt::US9688672, Example 348	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 177					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247745	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247745&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454322	346542284							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472238	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OC(F)F)cc2)n1	InChI=1S/C18H20F2N4O4/c1-10(12-3-5-13(6-4-12)28-16(19)20)22-17-21-8-7-15(23-17)24-14(11(2)25)9-27-18(24)26/h3-8,10-11,14,16,25H,9H2,1-2H3,(H,21,22,23)/t10-,11+,14+/m0/s1	XWGFOVNGXKQOSI-MISXGVKJSA-N	247746	US10112931, Example 349::US9434719, 349 as TFA salt::US9688672, Example 349	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 681					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247746	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247746&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454448	346542285							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472239	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OC(F)F)cc2F)n1	InChI=1S/C18H19F3N4O4/c1-9(12-4-3-11(7-13(12)19)29-16(20)21)23-17-22-6-5-15(24-17)25-14(10(2)26)8-28-18(25)27/h3-7,9-10,14,16,26H,8H2,1-2H3,(H,22,23,24)/t9-,10+,14+/m0/s1	YFLKUCNNFILRRP-IMSIIYSGSA-N	247747	US10112931, Example 350::US9434719, 350 as TFA salt::US9688672, Example 350	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 413					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247747	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247747&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454330	346542286							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472240	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cccc(OC(F)(F)F)c2)n1	InChI=1S/C18H19F3N4O4/c1-10(12-4-3-5-13(8-12)29-18(19,20)21)23-16-22-7-6-15(24-16)25-14(11(2)26)9-28-17(25)27/h3-8,10-11,14,26H,9H2,1-2H3,(H,22,23,24)/t10-,11+,14+/m0/s1	PKLONOWRTBRHFD-MISXGVKJSA-N	247748	US10112931, Example 351::US9434719, 351 as TFA salt::US9688672, Example 351	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 168					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247748	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247748&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454411	346542287							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472241	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cccc(OC(F)F)c2)n1	InChI=1S/C18H20F2N4O4/c1-10(12-4-3-5-13(8-12)28-16(19)20)22-17-21-7-6-15(23-17)24-14(11(2)25)9-27-18(24)26/h3-8,10-11,14,16,25H,9H2,1-2H3,(H,21,22,23)/t10-,11+,14+/m0/s1	PKRAGBQEVPWLDS-MISXGVKJSA-N	247749	US10112931, Example 352::US9434719, 352 as TFA salt::US9688672, Example 352	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 770					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247749	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247749&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454419	346542288							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472242	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OC(F)F)cc2F)ncc1F	InChI=1S/C18H18F4N4O4/c1-8(11-4-3-10(5-12(11)19)30-16(21)22)24-17-23-6-13(20)15(25-17)26-14(9(2)27)7-29-18(26)28/h3-6,8-9,14,16,27H,7H2,1-2H3,(H,23,24,25)/t8-,9+,14+/m0/s1	YDCZLLOGUUVLIS-ATEUNZGCSA-N	247750	US10112931, Example 353::US9434719, 353 as TFA salt::US9688672, Example 353	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 103					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247750	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247750&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454335	346542289							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472243	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cccc(OC(F)(F)F)c2)ncc1F	InChI=1S/C18H18F4N4O4/c1-9(11-4-3-5-12(6-11)30-18(20,21)22)24-16-23-7-13(19)15(25-16)26-14(10(2)27)8-29-17(26)28/h3-7,9-10,14,27H,8H2,1-2H3,(H,23,24,25)/t9-,10+,14+/m0/s1	JSGZIGKPIXFXHH-IMSIIYSGSA-N	247751	US10112931, Example 354::US9434719, 354 as TFA salt::US9688672, Example 354	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 51					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247751	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247751&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454312	346542290							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472244	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cccc(OC(F)F)c2)ncc1F	InChI=1S/C18H19F3N4O4/c1-9(11-4-3-5-12(6-11)29-16(20)21)23-17-22-7-13(19)15(24-17)25-14(10(2)26)8-28-18(25)27/h3-7,9-10,14,16,26H,8H2,1-2H3,(H,22,23,24)/t9-,10+,14+/m0/s1	LMGCJWUBCBQFCU-IMSIIYSGSA-N	247752	US10112931, Example 355::US9434719, 355 as TFA salt::US9688672, Example 355	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 152					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247752	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247752&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454444	346542291							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472245	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cccc(Oc3ccccc3)c2)n1	InChI=1S/C23H24N4O4/c1-15(17-7-6-10-19(13-17)31-18-8-4-3-5-9-18)25-22-24-12-11-21(26-22)27-20(16(2)28)14-30-23(27)29/h3-13,15-16,20,28H,14H2,1-2H3,(H,24,25,26)/t15-,16+,20+/m0/s1	AEQXLYPLJRGDNI-RZQQEMMASA-N	247753	US10112931, Example 356::US9434719, 356 as TFA salt::US9688672, Example 356	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 120					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247753	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247753&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416330	346542292							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472246	CC(C)Oc1ccc(cc1)[C@H](C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O	InChI=1S/C20H26N4O4/c1-12(2)28-16-7-5-15(6-8-16)13(3)22-19-21-10-9-18(23-19)24-17(14(4)25)11-27-20(24)26/h5-10,12-14,17,25H,11H2,1-4H3,(H,21,22,23)/t13-,14+,17+/m0/s1	OJWQIUREUZEYHW-JJRVBVJISA-N	247754	US10112931, Example 357::US9434719, 357 as TFA salt::US9688672, Example 357	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 358					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247754	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247754&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454415	346542293							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472247	CC(C)COc1ccc(cc1C)[C@H](C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O	InChI=1S/C22H30N4O4/c1-13(2)11-29-19-7-6-17(10-14(19)3)15(4)24-21-23-9-8-20(25-21)26-18(16(5)27)12-30-22(26)28/h6-10,13,15-16,18,27H,11-12H2,1-5H3,(H,23,24,25)/t15-,16+,18+/m0/s1	GHWKXMZIPLJSMM-LZLYRXPVSA-N	247755	US10112931, Example 358::US9434719, 358 as TFA salt::US9688672, Example 358	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 123					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247755	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247755&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454311	346542294							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472248	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(OC(F)(F)F)cc2)n1	InChI=1S/C18H18ClF3N4O4/c1-9(11-3-5-12(6-4-11)30-18(20,21)22)23-16-24-14(19)7-15(25-16)26-13(10(2)27)8-29-17(26)28/h3-7,9-10,13,27H,8H2,1-2H3,(H,23,24,25)/t9-,10+,13+/m0/s1	SLTPWQWFEDBFLL-OPQQBVKSSA-N	247756	US10112931, Example 359::US9434719, 359 as TFA salt::US9688672, Example 359	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 171					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247756	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247756&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454325	346542295							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472249	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OC(F)(F)F)cc2)ncc1F	InChI=1S/C18H18F4N4O4/c1-9(11-3-5-12(6-4-11)30-18(20,21)22)24-16-23-7-13(19)15(25-16)26-14(10(2)27)8-29-17(26)28/h3-7,9-10,14,27H,8H2,1-2H3,(H,23,24,25)/t9-,10+,14+/m0/s1	SWVDZCOMSHWEEZ-IMSIIYSGSA-N	247757	US10112931, Example 360::US9434719, 360 as TFA salt::US9688672, Example 360	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 56					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247757	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247757&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454340	346542296							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472250	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(OC(F)(F)F)cc2F)n1	InChI=1S/C18H17ClF4N4O4/c1-8(11-4-3-10(5-12(11)20)31-18(21,22)23)24-16-25-14(19)6-15(26-16)27-13(9(2)28)7-30-17(27)29/h3-6,8-9,13,28H,7H2,1-2H3,(H,24,25,26)/t8-,9+,13+/m0/s1	SWAWFUARYJDPBB-IGJMFERPSA-N	247758	US10112931, Example 361::US9434719, 361 as TFA salt::US9688672, Example 361	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 107					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247758	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247758&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454314	346542297							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472251	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OC(F)(F)F)cc2F)ncc1F	InChI=1S/C18H17F5N4O4/c1-8(11-4-3-10(5-12(11)19)31-18(21,22)23)25-16-24-6-13(20)15(26-16)27-14(9(2)28)7-30-17(27)29/h3-6,8-9,14,28H,7H2,1-2H3,(H,24,25,26)/t8-,9+,14+/m0/s1	HDTHZQWZFMBYRG-ATEUNZGCSA-N	247759	US10112931, Example 362::US9434719, 362 as TFA salt::US9688672, Example 362	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 72					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247759	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247759&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454351	346542298							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472252	CC(C)COc1ccc([C@H](C)Nc2ncc(F)c(n2)N2[C@H](COC2=O)[C@@H](C)O)c(F)c1	InChI=1S/C21H26F2N4O4/c1-11(2)9-30-14-5-6-15(16(22)7-14)12(3)25-20-24-8-17(23)19(26-20)27-18(13(4)28)10-31-21(27)29/h5-8,11-13,18,28H,9-10H2,1-4H3,(H,24,25,26)/t12-,13+,18+/m0/s1	DMKMOSRSPBXKFD-VEVIJQCQSA-N	247760	US10112931, Example 363::US9434719, 363 as TFA salt::US9688672, Example 363	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7.00					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247760	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247760&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269624	346542299							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472253	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OC(F)F)cc2)ncc1F	InChI=1S/C18H19F3N4O4/c1-9(11-3-5-12(6-4-11)29-16(20)21)23-17-22-7-13(19)15(24-17)25-14(10(2)26)8-28-18(25)27/h3-7,9-10,14,16,26H,8H2,1-2H3,(H,22,23,24)/t9-,10+,14+/m0/s1	FQHLHYFBIHYYEA-IMSIIYSGSA-N	247761	US10112931, Example 364::US9434719, 364 as TFA salt::US9688672, Example 364	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 124					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247761	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247761&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454323	346542300							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472254	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OC(F)(F)F)c(F)c2)ncc1F	InChI=1S/C18H17F5N4O4/c1-8(10-3-4-14(11(19)5-10)31-18(21,22)23)25-16-24-6-12(20)15(26-16)27-13(9(2)28)7-30-17(27)29/h3-6,8-9,13,28H,7H2,1-2H3,(H,24,25,26)/t8-,9+,13+/m0/s1	GYAMWEZQXHMOAV-IGJMFERPSA-N	247762	US10112931, Example 365::US9434719, 365 as TFA salt::US9688672, Example 365	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 33					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247762	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247762&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454328	346542301							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472255	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(OC(F)F)cc2)n1	InChI=1S/C18H19ClF2N4O4/c1-9(11-3-5-12(6-4-11)29-16(20)21)22-17-23-14(19)7-15(24-17)25-13(10(2)26)8-28-18(25)27/h3-7,9-10,13,16,26H,8H2,1-2H3,(H,22,23,24)/t9-,10+,13+/m0/s1	VLNLAVUCHCZALI-OPQQBVKSSA-N	247763	US10112931, Example 366::US9434719, 366 as TFA salt::US9688672, Example 366	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 151					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247763	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247763&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454337	346542302							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472256	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(OC(F)(F)F)c(F)c2)n1	InChI=1S/C18H17ClF4N4O4/c1-8(10-3-4-13(11(20)5-10)31-18(21,22)23)24-16-25-14(19)6-15(26-16)27-12(9(2)28)7-30-17(27)29/h3-6,8-9,12,28H,7H2,1-2H3,(H,24,25,26)/t8-,9+,12+/m0/s1	YRQFYFCQIZEOKP-YGOYTEALSA-N	247764	US10112931, Example 367::US9434719, 367 as TFA salt::US9688672, Example 367	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 127					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247764	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247764&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454352	346542303							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472257	CC(C)CS(=O)(=O)c1ccc(cc1)[C@H](C)Nc1ncc(F)c(n1)N1[C@H](COC1=O)[C@@H](C)O	InChI=1S/C21H27FN4O5S/c1-12(2)11-32(29,30)16-7-5-15(6-8-16)13(3)24-20-23-9-17(22)19(25-20)26-18(14(4)27)10-31-21(26)28/h5-9,12-14,18,27H,10-11H2,1-4H3,(H,23,24,25)/t13-,14+,18+/m0/s1	BENRISSQCAMHJD-PMUMKWKESA-N	247765	US10112931, Example 368::US9434719, 368 as TFA salt::US9688672, Example 368	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 91					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247765	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247765&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454315	346542304							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472258	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2)S(=O)(=O)C(C)C)ncc1F	InChI=1S/C20H25FN4O5S/c1-11(2)31(28,29)15-7-5-14(6-8-15)12(3)23-19-22-9-16(21)18(24-19)25-17(13(4)26)10-30-20(25)27/h5-9,11-13,17,26H,10H2,1-4H3,(H,22,23,24)/t12-,13+,17+/m0/s1	AKIWXGQITISGLG-OGHNNQOOSA-N	247766	US10112931, Example 369::US9434719, 369 as TFA salt::US9688672, Example 369	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 397					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247766	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247766&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454327	346542305							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472259	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(cc2)S(=O)(=O)C(C)C)n1	InChI=1S/C20H25ClN4O5S/c1-11(2)31(28,29)15-7-5-14(6-8-15)12(3)22-19-23-17(21)9-18(24-19)25-16(13(4)26)10-30-20(25)27/h5-9,11-13,16,26H,10H2,1-4H3,(H,22,23,24)/t12-,13+,16+/m0/s1	VYAVVBNXCNPSAJ-WOSRLPQWSA-N	247767	US10112931, Example 370::US9434719, 370 as TFA salt::US9688672, Example 370	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 441					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247767	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247767&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454420	346542306							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472260	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OCC3CC3)cc2)n1	InChI=1S/C21H26N4O4/c1-13(16-5-7-17(8-6-16)28-11-15-3-4-15)23-20-22-10-9-19(24-20)25-18(14(2)26)12-29-21(25)27/h5-10,13-15,18,26H,3-4,11-12H2,1-2H3,(H,22,23,24)/t13-,14+,18+/m0/s1	ZCOLCSIPNKKCDE-PMUMKWKESA-N	247768	US10112931, Example 371::US9434719, 371 as TFA salt::US9688672, Example 371	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 125					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247768	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247768&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454354	346542307							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472261	CC(C)COc1ccc([C@H](C)Nc2nccc(n2)N2[C@H](COC2=O)[C@@H](C)O)c(F)c1	InChI=1S/C21H27FN4O4/c1-12(2)10-29-15-5-6-16(17(22)9-15)13(3)24-20-23-8-7-19(25-20)26-18(14(4)27)11-30-21(26)28/h5-9,12-14,18,27H,10-11H2,1-4H3,(H,23,24,25)/t13-,14+,18+/m0/s1	LJIFTDXMEPVARJ-PMUMKWKESA-N	247769	US10112931, Example 372::US9434719, 372 as TFA salt::US9688672, Example 372	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247769	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247769&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269625	346542308							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472262	CO[C@H](C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H22ClN5O3S/c1-12(17-10-24-19(31-17)14-4-6-15(22)7-5-14)25-20-23-9-8-18(26-20)27-16(13(2)29-3)11-30-21(27)28/h4-10,12-13,16H,11H2,1-3H3,(H,23,25,26)/t12-,13+,16+/m0/s1	SAIODZDRCACKIB-WOSRLPQWSA-N	247770	US10112931, Example 373::US9434719, 373 as TFA salt::US9688672, Example 373	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 51					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247770	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247770&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414996	346542309							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472263	CO[C@H](C)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(F)c(cc2F)-c2cnn(C)c2)n1	InChI=1S/C22H23ClF2N6O3/c1-11(14-5-17(25)15(6-16(14)24)13-8-26-30(3)9-13)27-21-28-19(23)7-20(29-21)31-18(12(2)33-4)10-34-22(31)32/h5-9,11-12,18H,10H2,1-4H3,(H,27,28,29)/t11-,12+,18+/m0/s1	HNOZDTOTLCCUPT-VNBZBWLYSA-N	247771	US10112931, Example 374::US9434719, 374::US9688672, Example 374	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 32					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247771	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247771&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454332	346542310							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472264	CO[C@H](C)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(cc2F)C(F)(F)F)n1	InChI=1S/C19H19ClF4N4O3/c1-9(12-5-4-11(6-13(12)21)19(22,23)24)25-17-26-15(20)7-16(27-17)28-14(10(2)30-3)8-31-18(28)29/h4-7,9-10,14H,8H2,1-3H3,(H,25,26,27)/t9-,10+,14+/m0/s1	IAZOCXPCSBFWIH-IMSIIYSGSA-N	247772	US10112931, Example 375::US9434719, 375::US9688672, Example 375	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 93					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247772	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247772&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454333	346542311							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472265	CO[C@H](C)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H21Cl2N5O3S/c1-11(16-9-24-19(32-16)13-4-6-14(22)7-5-13)25-20-26-17(23)8-18(27-20)28-15(12(2)30-3)10-31-21(28)29/h4-9,11-12,15H,10H2,1-3H3,(H,25,26,27)/t11-,12+,15+/m0/s1	IQBNFHYCKUJXMY-YWPYICTPSA-N	247773	US10112931, Example 376::US9434719, 376 as TFA salt::US9688672, Example 376	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 23					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247773	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247773&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269626	346542312							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472266	CO[C@H](C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H22ClN5O4/c1-12(16-10-18(31-26-16)14-4-6-15(22)7-5-14)24-20-23-9-8-19(25-20)27-17(13(2)29-3)11-30-21(27)28/h4-10,12-13,17H,11H2,1-3H3,(H,23,24,25)/t12-,13+,17+/m0/s1	OCQDKNFJFBGAAN-OGHNNQOOSA-N	247774	US10112931, Example 377::US9434719, 377 as TFA salt::US9688672, Example 377	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 52					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247774	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247774&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454338	346542313							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472267	CO[C@H](C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H23ClN6O3/c1-13(17-10-27(12-24-17)16-6-4-15(22)5-7-16)25-20-23-9-8-19(26-20)28-18(14(2)30-3)11-31-21(28)29/h4-10,12-14,18H,11H2,1-3H3,(H,23,25,26)/t13-,14+,18+/m0/s1	ZXSRGQFMTVABKG-PMUMKWKESA-N	247775	US10112931, Example 378::US9434719, 378 as TFA salt::US9688672, Example 378	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 27					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247775	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247775&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269627	346542314							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472268	CO[C@H](C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-c2ccc(C)nc2)n1	InChI=1S/C24H25F2N5O3/c1-13-5-6-16(11-28-13)18-10-19(25)17(9-20(18)26)14(2)29-23-27-8-7-22(30-23)31-21(15(3)33-4)12-34-24(31)32/h5-11,14-15,21H,12H2,1-4H3,(H,27,29,30)/t14-,15+,21+/m0/s1	PXWHOSZDRFRQIM-PDSXEYIOSA-N	247776	US10112931, Example 379::US9434719, 379 as TFA salt::US9688672, Example 379	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 53					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247776	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247776&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454447	346542315							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472269	C[C@@H](N)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H21ClN6O2S/c1-11(22)15-10-29-20(28)27(15)17-7-8-23-19(26-17)25-12(2)16-9-24-18(30-16)13-3-5-14(21)6-4-13/h3-9,11-12,15H,10,22H2,1-2H3,(H,23,25,26)/t11-,12+,15-/m1/s1	TWTIWFVVDBVARH-TYNCELHUSA-N	247777	US10112931, Example 380::US9434719, 380::US9688672, Example 380	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 36					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247777	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247777&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269827	346542316							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472270	C[C@@H](N)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H21ClN6O2S/c1-11(22)15-10-29-20(28)27(15)17-7-8-23-19(26-17)25-12(2)16-9-24-18(30-16)13-3-5-14(21)6-4-13/h3-9,11-12,15H,10,22H2,1-2H3,(H,23,25,26)/t11-,12+,15-/m1/s1	TWTIWFVVDBVARH-TYNCELHUSA-N	247777	US10112931, Example 380::US9434719, 380::US9688672, Example 380	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 45					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247777	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247777&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269827	346542316							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472271	C[C@@H](N)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H22ClN7O2/c1-12(22)17-10-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)16-9-27(11-24-16)15-5-3-14(21)4-6-15/h3-9,11-13,17H,10,22H2,1-2H3,(H,23,25,26)/t12-,13+,17-/m1/s1	ZPVIMCNUFDJSOY-IIYDPXPESA-N	247778	US10112931, Example 381::US9434719, 381 as TFA salt::US9688672, Example 381	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 139					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247778	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247778&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454339	346542317							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472272	C[C@@H](N)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H21ClN6O3/c1-11(22)16-10-29-20(28)27(16)18-7-8-23-19(25-18)24-12(2)15-9-17(30-26-15)13-3-5-14(21)6-4-13/h3-9,11-12,16H,10,22H2,1-2H3,(H,23,24,25)/t11-,12+,16-/m1/s1	IFICRBVGACOUTK-BFQNTYOBSA-N	247779	US10112931, Example 382::US9434719, 382 as TFA salt::US9688672, Example 382	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 219					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247779	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247779&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454355	346542318							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472273	C[C@@H](N)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-c2ccc(C)nc2)n1	InChI=1S/C23H24F2N6O2/c1-12-4-5-15(10-28-12)17-9-18(24)16(8-19(17)25)14(3)29-22-27-7-6-21(30-22)31-20(13(2)26)11-33-23(31)32/h4-10,13-14,20H,11,26H2,1-3H3,(H,27,29,30)/t13-,14+,20-/m1/s1	VEDLXIHGLCIYPF-LAPQFRIASA-N	247780	US10112931, Example 383::US9434719, 383 as TFA salt::US9688672, Example 383	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 164					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247780	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247780&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454336	346542319							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472274	CN[C@H](C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H23ClN6O2S/c1-12(23-3)16-11-30-21(29)28(16)18-8-9-24-20(27-18)26-13(2)17-10-25-19(31-17)14-4-6-15(22)7-5-14/h4-10,12-13,16,23H,11H2,1-3H3,(H,24,26,27)/t12-,13+,16-/m1/s1	HSAYUWLDZHIRGI-DVOMOZLQSA-N	247781	US10112931, Example 384::US9434719, 384 as TFA salt::US9688672, Example 384	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17750					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247781	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247781&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415677	346542320							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472275	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H20ClFN6O2/c1-12(22)17-10-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)16-9-27(11-24-16)15-5-3-14(21)4-6-15/h3-9,11-13,17H,10H2,1-2H3,(H,23,25,26)/t12-,13+,17-/m1/s1	JJRFKCRKJUIUTG-IIYDPXPESA-N	247782	US10112931, Example 385::US9434719, 385::US9688672, Example 385	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247782	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247782&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269828	346542321							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472276	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H20ClFN6O2/c1-12(22)17-10-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)16-9-27(11-24-16)15-5-3-14(21)4-6-15/h3-9,11-13,17H,10H2,1-2H3,(H,23,25,26)/t12-,13+,17-/m1/s1	JJRFKCRKJUIUTG-IIYDPXPESA-N	247782	US10112931, Example 385::US9434719, 385::US9688672, Example 385	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 21					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247782	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247782&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269828	346542321							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472277	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H19ClFN5O3/c1-11(22)16-10-29-20(28)27(16)18-7-8-23-19(25-18)24-12(2)15-9-17(30-26-15)13-3-5-14(21)6-4-13/h3-9,11-12,16H,10H2,1-2H3,(H,23,24,25)/t11-,12+,16-/m1/s1	GQYRXSSAUNIXGN-BFQNTYOBSA-N	247783	US10112931, Example 386::US9434719, 386 as TFA salt::US9688672, Example 386	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 59					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247783	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247783&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454422	346542322							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472278	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H19ClFN5O2S/c1-11(22)15-10-29-20(28)27(15)17-7-8-23-19(26-17)25-12(2)16-9-24-18(30-16)13-3-5-14(21)6-4-13/h3-9,11-12,15H,10H2,1-2H3,(H,23,25,26)/t11-,12+,15-/m1/s1	YBAPMBOREDPGCY-TYNCELHUSA-N	247784	US10112931, Example 387::US9434719, 387 as TFA salt::US9688672, Example 387	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 34					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247784	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247784&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454317	346542323							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472279	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H20ClFN6O2/c1-12(22)17-10-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)16-9-27(11-24-16)15-5-3-14(21)4-6-15/h3-9,11-13,17H,10H2,1-2H3,(H,23,25,26)/t12-,13-,17+/m0/s1	JJRFKCRKJUIUTG-GDZNZVCISA-N	247785	US10112931, Example 388::US9434719, 388 as TFA salt::US9688672, Example 388	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247785	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247785&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269829	346542324							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472280	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H19ClFN5O2S/c1-11(22)15-10-29-20(28)27(15)17-7-8-23-19(26-17)25-12(2)16-9-24-18(30-16)13-3-5-14(21)6-4-13/h3-9,11-12,15H,10H2,1-2H3,(H,23,25,26)/t11-,12-,15+/m0/s1	YBAPMBOREDPGCY-SLEUVZQESA-N	247786	US10112931, Example 389::US9434719, 389 as TFA salt::US9688672, Example 389	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247786	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247786&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86270013	346542325							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472281	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H19ClFN5O3/c1-11(22)16-10-29-20(28)27(16)18-7-8-23-19(25-18)24-12(2)15-9-17(30-26-15)13-3-5-14(21)6-4-13/h3-9,11-12,16H,10H2,1-2H3,(H,23,24,25)/t11-,12-,16+/m0/s1	GQYRXSSAUNIXGN-MQIPJXDCSA-N	247787	US10112931, Example 390::US9434719, 390 as TFA salt::US9688672, Example 390	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247787	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247787&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86270014	346542326							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472282	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2nc(no2)-c2ccc(Cl)cc2)n1	InChI=1S/C19H18ClFN6O3/c1-10(21)14-9-29-19(28)27(14)15-7-8-22-18(24-15)23-11(2)17-25-16(26-30-17)12-3-5-13(20)6-4-12/h3-8,10-11,14H,9H2,1-2H3,(H,22,23,24)/t10-,11+,14-/m1/s1	GWEUWUPKNPRHLY-UHIISALHSA-N	247788	US10112931, Example 391::US9434719, 391 as TFA salt::US9688672, Example 391	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 53					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247788	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247788&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454334	346542327							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472283	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H18F4N6O2S/c1-10(21)13-9-32-19(31)30(13)16-4-6-26-18(29-16)28-11(2)14-8-27-17(33-14)12-3-5-25-15(7-12)20(22,23)24/h3-8,10-11,13H,9H2,1-2H3,(H,26,28,29)/t10-,11+,13-/m1/s1	WGHDFKRAKKPLGU-NTZNESFSSA-N	247789	US10112931, Example 392::US9434719, 392 as TFA salt::US9688672, Example 392	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 121					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247789	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247789&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454341	346542328							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472284	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(nc2)C(F)(F)F)n1	InChI=1S/C20H18F4N6O2S/c1-10(21)13-9-32-19(31)30(13)16-5-6-25-18(29-16)28-11(2)14-8-27-17(33-14)12-3-4-15(26-7-12)20(22,23)24/h3-8,10-11,13H,9H2,1-2H3,(H,25,28,29)/t10-,11+,13-/m1/s1	QITCTFCYZWAPJB-NTZNESFSSA-N	247790	US10112931, Example 393::US9434719, 393 as TFA salt::US9688672, Example 393	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 69					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247790	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247790&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454446	346542329							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472285	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H20ClFN6O2/c1-12(22)17-11-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)14-9-24-27(10-14)16-5-3-15(21)4-6-16/h3-10,12-13,17H,11H2,1-2H3,(H,23,25,26)/t12-,13+,17-/m1/s1	NJHKNRVBHGOLEU-IIYDPXPESA-N	247791	US10112931, Example 394::US9434719, 394 as TFA salt::US9688672, Example 394	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 41					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247791	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247791&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454450	346542330							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472286	C[C@@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C20H18ClF2N5O2S/c1-10(22)15-9-30-20(29)28(15)17-14(23)7-25-19(27-17)26-11(2)16-8-24-18(31-16)12-3-5-13(21)6-4-12/h3-8,10-11,15H,9H2,1-2H3,(H,25,26,27)/t10-,11+,15-/m1/s1	UIZLKFKSWCSCMM-JRPNMDOOSA-N	247792	US10112931, Example 395::US9434719, 395 as TFA salt::US9688672, Example 395	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 40					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247792	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247792&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454342	346542331							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472287	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1	InChI=1S/C20H20ClFN6O2/c1-12(22)17-11-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)14-9-24-27(10-14)16-5-3-15(21)4-6-16/h3-10,12-13,17H,11H2,1-2H3,(H,23,25,26)/t12-,13-,17+/m0/s1	NJHKNRVBHGOLEU-GDZNZVCISA-N	247793	US10112931, Example 396::US9434719, 396 as TFA salt::US9688672, Example 396	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 33					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247793	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247793&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454329	346542332							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472288	C[C@@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C20H19ClF2N6O2/c1-11(22)17-10-31-20(30)29(17)18-16(23)8-24-19(27-18)26-12(2)13-7-25-28(9-13)15-5-3-14(21)4-6-15/h3-9,11-12,17H,10H2,1-2H3,(H,24,26,27)/t11-,12+,17-/m1/s1	YFWQMXWNYLZFPV-BWACUDIHSA-N	247794	US10112931, Example 397::US9434719, 397 as TFA salt::US9688672, Example 397	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 66					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247794	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247794&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454421	346542333							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472289	C[C@@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C20H18ClF2N5O3/c1-10(22)16-9-30-20(29)28(16)18-14(23)8-24-19(26-18)25-11(2)15-7-17(31-27-15)12-3-5-13(21)6-4-12/h3-8,10-11,16H,9H2,1-2H3,(H,24,25,26)/t10-,11+,16-/m1/s1	KPUWPLMVSGVTML-OHUAYANFSA-N	175633	US10112931, Example 398::US9688672, Example 398	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 39					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175633	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175633&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454449	363892473							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472290	C[C@@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C20H19ClF2N6O2/c1-11(22)17-9-31-20(30)29(17)18-15(23)7-24-19(27-18)26-12(2)16-8-28(10-25-16)14-5-3-13(21)4-6-14/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)/t11-,12+,17-/m1/s1	TXJIZORMCOMGCK-BWACUDIHSA-N	247796	US10112931, Example 399::US9434719, 399 as TFA salt::US9688672, Example 399	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247796	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247796&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86270015	346542335							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472291	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(c(C)n2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H22ClFN6O2/c1-12(23)18-11-31-21(30)29(18)19-8-9-24-20(27-19)25-13(2)17-10-28(14(3)26-17)16-6-4-15(22)5-7-16/h4-10,12-13,18H,11H2,1-3H3,(H,24,25,27)/t12-,13-,18+/m0/s1	ZQMNNLVJLTTWPP-ZJNRKIDTSA-N	247797	US10112931, Example 400::US9434719, 400 as TFA salt::US9688672, Example 400	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 26					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247797	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247797&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269830	346542336							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472292	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(F)cc2)n1	InChI=1S/C20H20F2N6O2/c1-12(21)17-10-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)16-9-27(11-24-16)15-5-3-14(22)4-6-15/h3-9,11-13,17H,10H2,1-2H3,(H,23,25,26)/t12-,13-,17+/m0/s1	QPJBWMOBPCRKLJ-GDZNZVCISA-N	247798	US10112931, Example 401::US9434719, 401::US9688672, Example 401	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 26					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247798	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247798&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269831	346542337							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472293	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(F)cc2)n1	InChI=1S/C20H20F2N6O2/c1-12(21)17-10-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)16-9-27(11-24-16)15-5-3-14(22)4-6-15/h3-9,11-13,17H,10H2,1-2H3,(H,23,25,26)/t12-,13-,17+/m0/s1	QPJBWMOBPCRKLJ-GDZNZVCISA-N	247798	US10112931, Example 401::US9434719, 401::US9688672, Example 401	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247798	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247798&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269831	346542337							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472294	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-n2cnc(C)c2)n1	InChI=1S/C21H21F3N6O2/c1-11-8-29(10-26-11)17-7-15(23)14(6-16(17)24)13(3)27-20-25-5-4-19(28-20)30-18(12(2)22)9-32-21(30)31/h4-8,10,12-13,18H,9H2,1-3H3,(H,25,27,28)/t12-,13-,18+/m0/s1	WXQFMXGYILZLDK-ZJNRKIDTSA-N	247799	US10112931, Example 402::US9434719, 402 as TFA salt::US9688672, Example 402	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 47					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247799	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247799&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454356	346542338							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472295	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccn(n2)-c2ccc(nc2)C(F)(F)F)n1	InChI=1S/C20H19F4N7O2/c1-11(21)15-10-33-19(32)31(15)17-5-7-25-18(28-17)27-12(2)14-6-8-30(29-14)13-3-4-16(26-9-13)20(22,23)24/h3-9,11-12,15H,10H2,1-2H3,(H,25,27,28)/t11-,12-,15+/m0/s1	QLUIPEQIKSKHHT-SLEUVZQESA-N	247800	US10112931, Example 403::US9434719, 403 as TFA salt::US9688672, Example 403	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 137					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247800	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247800&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415067	346542339							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472296	C[C@H](Nc1nccc(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(Cl)cc1	InChI=1S/C19H18ClFN6O2/c1-12(16-9-26(11-23-16)14-4-2-13(20)3-5-14)24-18-22-7-6-17(25-18)27-15(8-21)10-29-19(27)28/h2-7,9,11-12,15H,8,10H2,1H3,(H,22,24,25)/t12-,15-/m0/s1	KPEQYRKGPMZOQE-WFASDCNBSA-N	247801	US10112931, Example 404::US9434719, 404::US9688672, Example 404	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 23					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247801	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247801&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269832	346542340							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472297	C[C@H](Nc1nccc(n1)N1[C@@H](CF)COC1=O)c1cc(on1)-c1ccc(Cl)cc1	InChI=1S/C19H17ClFN5O3/c1-11(15-8-16(29-25-15)12-2-4-13(20)5-3-12)23-18-22-7-6-17(24-18)26-14(9-21)10-28-19(26)27/h2-8,11,14H,9-10H2,1H3,(H,22,23,24)/t11-,14-/m0/s1	BFRYXYOIUNFQSA-FZMZJTMJSA-N	247802	US10112931, Example 405::US9434719, 405::US9688672, Example 405	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 32					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247802	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247802&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452072	346542341							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472298	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(c(C)n2)-c2ccc(Cl)cc2)n1	InChI=1S/C21H22ClFN6O2/c1-12(23)18-11-31-21(30)29(18)19-8-9-24-20(27-19)25-13(2)17-10-28(14(3)26-17)16-6-4-15(22)5-7-16/h4-10,12-13,18H,11H2,1-3H3,(H,24,25,27)/t12-,13+,18-/m1/s1	ZQMNNLVJLTTWPP-FHSNZYRGSA-N	247803	US10112931, Example 406::US9434719, 406 as TFA salt::US9688672, Example 406	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247803	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247803&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452073	346542342							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472299	CC(O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)C2CCN(CC2)c2ccnc(c2)C(C)(C)C(F)(F)F)n1	InChI=1S/C25H33F3N6O3/c1-15(31-22-30-10-6-21(32-22)34-19(16(2)35)14-37-23(34)36)17-7-11-33(12-8-17)18-5-9-29-20(13-18)24(3,4)25(26,27)28/h5-6,9-10,13,15-17,19,35H,7-8,11-12,14H2,1-4H3,(H,30,31,32)/t15-,16?,19+/m0/s1	WSAGULHYKDXCCD-SCVGIUIWSA-N	247804	US10112931, Example 407::US9434719, 407::US9688672, Example 407	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 71					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247804	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247804&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452074	346542343							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472300	CC(O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)C2CCN(CC2)c2ccc(Cl)c(OC(F)(F)F)c2)n1	InChI=1S/C23H27ClF3N5O4/c1-13(29-21-28-8-5-20(30-21)32-18(14(2)33)12-35-22(32)34)15-6-9-31(10-7-15)16-3-4-17(24)19(11-16)36-23(25,26)27/h3-5,8,11,13-15,18,33H,6-7,9-10,12H2,1-2H3,(H,28,29,30)/t13-,14?,18+/m0/s1	GMDXACMJICLXKB-IXRXBBNISA-N	175643	BDBM247805::US10112931, Example 408::US9688672, Example 408	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 43					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175643	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175643&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			131635548	363892483							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472301	C[C@H](Nc1ncc(F)c(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1ccc(cc1F)C(F)F	InChI=1S/C19H18F6N4O2/c1-8(15(22)23)14-7-31-19(30)29(14)17-13(21)6-26-18(28-17)27-9(2)11-4-3-10(16(24)25)5-12(11)20/h3-6,8-9,14-16H,7H2,1-2H3,(H,26,27,28)/t8-,9+,14-/m1/s1	SIYAUCMYORHPJS-TVLCNXBWSA-N	247806	US10112931, Example 409::US9434719, 409 as TFA salt::US9688672, Example 409	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 209					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247806	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247806&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414243	346542345							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472302	CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1nc(no1)-c1ccc(Cl)cc1	InChI=1S/C20H19ClF2N6O3/c1-10(16(22)23)14-9-31-20(30)29(14)15-7-8-24-19(26-15)25-11(2)18-27-17(28-32-18)12-3-5-13(21)6-4-12/h3-8,10-11,14,16H,9H2,1-2H3,(H,24,25,26)/t10-,11?,14-/m1/s1	NOOITAIFTJACTE-VBCZDQSUSA-N	247807	US10112931, Example 411::US9434719, 411 as TFA salt::US9688672, Example 411	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247807	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247807&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454326	346542346							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472303	CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1nc(no1)-c1ccc(Cl)cc1	InChI=1S/C20H19ClF2N6O3/c1-10(16(22)23)14-9-31-20(30)29(14)15-7-8-24-19(26-15)25-11(2)18-27-17(28-32-18)12-3-5-13(21)6-4-12/h3-8,10-11,14,16H,9H2,1-2H3,(H,24,25,26)/t10-,11?,14-/m1/s1	NOOITAIFTJACTE-VBCZDQSUSA-N	247807	US10112931, Example 411::US9434719, 411 as TFA salt::US9688672, Example 411	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 756					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247807	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247807&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454326	346542346							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472304	C[C@H](Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1ccc(cc1F)C(F)F	InChI=1S/C19H19F5N4O2/c1-9(16(21)22)14-8-30-19(29)28(14)15-5-6-25-18(27-15)26-10(2)12-4-3-11(17(23)24)7-13(12)20/h3-7,9-10,14,16-17H,8H2,1-2H3,(H,25,26,27)/t9-,10+,14-/m1/s1	VLOHNXLYDJXLOT-ISTVAULSSA-N	247808	US10112931, Example 412::US9434719, 412 as TFA salt::US9688672, Example 412	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 108					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247808	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247808&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414308	346542347							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472305	CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1ncc(cn1)-c1ccc(F)c(C)c1	InChI=1S/C23H23F3N6O2/c1-12-8-15(4-5-17(12)24)16-9-28-21(29-10-16)14(3)30-22-27-7-6-19(31-22)32-18(11-34-23(32)33)13(2)20(25)26/h4-10,13-14,18,20H,11H2,1-3H3,(H,27,30,31)/t13-,14?,18-/m1/s1	WWYFVFJZLKWRGV-VZGYSGOJSA-N	247809	US10112931, Example 414::US9434719, 414 as TFA salt::US9688672, Example 414	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 23					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247809	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247809&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454324	346542348							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472306	CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1ncc(cn1)-c1ccc(F)c(C)c1	InChI=1S/C23H23F3N6O2/c1-12-8-15(4-5-17(12)24)16-9-28-21(29-10-16)14(3)30-22-27-7-6-19(31-22)32-18(11-34-23(32)33)13(2)20(25)26/h4-10,13-14,18,20H,11H2,1-3H3,(H,27,30,31)/t13-,14?,18-/m1/s1	WWYFVFJZLKWRGV-VZGYSGOJSA-N	247809	US10112931, Example 414::US9434719, 414 as TFA salt::US9688672, Example 414	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2210					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247809	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247809&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454324	346542348							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472307	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc3ccn(C)c3c2)n1	InChI=1S/C22H23N7O4/c1-12(20-26-19(27-33-20)15-5-4-14-7-9-28(3)16(14)10-15)24-21-23-8-6-18(25-21)29-17(13(2)30)11-32-22(29)31/h4-10,12-13,17,30H,11H2,1-3H3,(H,23,24,25)/t12?,13-,17-/m1/s1	HGCRGOJZYKVSGJ-QQGYXAEISA-N	247810	US10112931, Example 415::US9434719, 415::US9688672, Example 415	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 671					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247810	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247810&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452076	346542349							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472308	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(OC(F)(F)F)c2)n1	InChI=1S/C20H19F3N6O5/c1-10(17-27-16(28-34-17)12-4-3-5-13(8-12)33-20(21,22)23)25-18-24-7-6-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)/t10?,11-,14-/m1/s1	ZJFRSZUNHMBIIV-MDLDFJCZSA-N	247811	US10112931, Example 416::US9434719, 416::US9688672, Example 416	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 97					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247811	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247811&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452075	346542350							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472309	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc3n(C)c(C)cc23)n1	InChI=1S/C23H25N7O4/c1-12-10-16-15(6-5-7-17(16)29(12)4)20-27-21(34-28-20)13(2)25-22-24-9-8-19(26-22)30-18(14(3)31)11-33-23(30)32/h5-10,13-14,18,31H,11H2,1-4H3,(H,24,25,26)/t13?,14-,18-/m1/s1	GBVOTMFBOODMEE-JDPNFYKBSA-N	247812	US10112931, Example 417::US9434719, 417::US9688672, Example 417	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 207					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247812	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247812&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452078	346542351							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472310	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)c(OC(F)(F)F)c2)n1	InChI=1S/C20H18ClF3N6O5/c1-9(26-18-25-6-5-15(27-18)30-13(10(2)31)8-33-19(30)32)17-28-16(29-35-17)11-3-4-12(21)14(7-11)34-20(22,23)24/h3-7,9-10,13,31H,8H2,1-2H3,(H,25,26,27)/t9?,10-,13-/m1/s1	NXPYTJOUNUPUMU-SVLLLCHKSA-N	247813	US10112931, Example 418::US9434719, 418::US9688672, Example 418	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247813	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247813&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452077	346542352							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472311	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)c(C)c2)n1	InChI=1S/C20H21ClN6O4/c1-10-8-13(4-5-14(10)21)17-25-18(31-26-17)11(2)23-19-22-7-6-16(24-19)27-15(12(3)28)9-30-20(27)29/h4-8,11-12,15,28H,9H2,1-3H3,(H,22,23,24)/t11?,12-,15-/m1/s1	CTNWFAVTVAQWHU-AADWAWOOSA-N	247814	US10112931, Example 419::US9434719, 419::US9688672, Example 419	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 96					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247814	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247814&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452079	346542353							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472312	COc1cc(ccc1Br)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O	InChI=1S/C20H21BrN6O5/c1-10(18-25-17(26-32-18)12-4-5-13(21)15(8-12)30-3)23-19-22-7-6-16(24-19)27-14(11(2)28)9-31-20(27)29/h4-8,10-11,14,28H,9H2,1-3H3,(H,22,23,24)/t10?,11-,14-/m1/s1	UFWGCYQKPCABFB-MDLDFJCZSA-N	247815	US10112931, Example 420::US9434719, 420::US9688672, Example 420	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 89					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247815	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247815&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452081	346542354							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472313	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(c2)C(C)(C)C)n1	InChI=1S/C23H28N6O4/c1-13(20-27-19(28-33-20)15-7-6-8-16(11-15)23(3,4)5)25-21-24-10-9-18(26-21)29-17(14(2)30)12-32-22(29)31/h6-11,13-14,17,30H,12H2,1-5H3,(H,24,25,26)/t13?,14-,17-/m1/s1	PYBGXOXYGBVPRM-DTLKIFBZSA-N	247816	US10112931, Example 421::US9434719, 421::US9688672, Example 421	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 23					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247816	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247816&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452080	346542355							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472314	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc3CCCc3c2)n1	InChI=1S/C22H24N6O4/c1-12(20-26-19(27-32-20)16-7-6-14-4-3-5-15(14)10-16)24-21-23-9-8-18(25-21)28-17(13(2)29)11-31-22(28)30/h6-10,12-13,17,29H,3-5,11H2,1-2H3,(H,23,24,25)/t12?,13-,17-/m1/s1	BOZGVLGFGSEXBU-QQGYXAEISA-N	247817	US10112931, Example 423::US9434719, 423::US9688672, Example 423	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1895					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247817	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247817&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452082	346542356							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472315	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc3CCCc3c2)n1	InChI=1S/C22H24N6O4/c1-12(20-26-19(27-32-20)16-7-6-14-4-3-5-15(14)10-16)24-21-23-9-8-18(25-21)28-17(13(2)29)11-31-22(28)30/h6-10,12-13,17,29H,3-5,11H2,1-2H3,(H,23,24,25)/t12?,13-,17-/m1/s1	BOZGVLGFGSEXBU-QQGYXAEISA-N	247817	US10112931, Example 423::US9434719, 423::US9688672, Example 423	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 39					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247817	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247817&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452082	346542356							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472316	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2noc(n2)-c2ccc(Cl)cc2)n1	InChI=1S/C19H19ClN6O4/c1-10(16-24-17(30-25-16)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)/t10?,11-,14-/m1/s1	HQFBCUBMPLPKFP-MDLDFJCZSA-N	247818	US10112931, Example 425::US9434719, 425::US9688672, Example 425	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7710					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247818	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247818&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414634	346542357							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472317	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2noc(n2)-c2ccc(Cl)cc2)n1	InChI=1S/C19H19ClN6O4/c1-10(16-24-17(30-25-16)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)/t10?,11-,14-/m1/s1	HQFBCUBMPLPKFP-MDLDFJCZSA-N	247818	US10112931, Example 425::US9434719, 425::US9688672, Example 425	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 303					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247818	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247818&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414634	346542357							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472318	C[C@H](Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1cn(cn1)-c1ccc(Cl)cc1	InChI=1S/C21H21ClF2N6O2/c1-12(19(23)24)17-10-32-21(31)30(17)18-7-8-25-20(28-18)27-13(2)16-9-29(11-26-16)15-5-3-14(22)4-6-15/h3-9,11-13,17,19H,10H2,1-2H3,(H,25,27,28)/t12-,13+,17-/m1/s1	ISURFSGOOSPXEW-IIYDPXPESA-N	247819	US10112931, Example 426::US9434719, 426 as TFA salt::US9688672, Example 426	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247819	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247819&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86270012	346542358							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472319	C[C@H](Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1cn(cn1)-c1ccc(F)cc1	InChI=1S/C21H21F3N6O2/c1-12(19(23)24)17-10-32-21(31)30(17)18-7-8-25-20(28-18)27-13(2)16-9-29(11-26-16)15-5-3-14(22)4-6-15/h3-9,11-13,17,19H,10H2,1-2H3,(H,25,27,28)/t12-,13+,17-/m1/s1	DKEIWINCRUGBON-IIYDPXPESA-N	247820	US10112931, Example 427::US9434719, 427 as TFA salt::US9688672, Example 427	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 295					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247820	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247820&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414508	346542359							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472320	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccnc(F)c2)n1	InChI=1S/C19H18F2N6O2S/c1-10(20)13-9-29-19(28)27(13)16-4-6-23-18(26-16)25-11(2)14-8-24-17(30-14)12-3-5-22-15(21)7-12/h3-8,10-11,13H,9H2,1-2H3,(H,23,25,26)/t10-,11-,13+/m0/s1	LLBAUGAZAHYFIF-GMXVVIOVSA-N	175659	US9688672, Example 428	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 68					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175659	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175659&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129286851	363892499							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472321	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(Cl)cc1	InChI=1S/C19H17ClF2N6O2/c1-11(16-8-27(10-24-16)13-4-2-12(20)3-5-13)25-18-23-7-15(22)17(26-18)28-14(6-21)9-30-19(28)29/h2-5,7-8,10-11,14H,6,9H2,1H3,(H,23,25,26)/t11-,14-/m0/s1	RRSNVVPVDMADPO-FZMZJTMJSA-N	247822	US10112931, Example 429::US9434719, 429::US9688672, Example 429	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247822	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247822&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452084	346542361							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472322	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(F)cc1	InChI=1S/C19H17F3N6O2/c1-11(16-8-27(10-24-16)13-4-2-12(21)3-5-13)25-18-23-7-15(22)17(26-18)28-14(6-20)9-30-19(28)29/h2-5,7-8,10-11,14H,6,9H2,1H3,(H,23,25,26)/t11-,14-/m0/s1	GXKZHLYWKDTOMF-FZMZJTMJSA-N	247823	US10112931, Example 430::US9434719, 430 as TFA salt::US9688672, Example 430	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 50					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247823	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247823&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452085	346542362							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472323	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(F)c(F)c1	InChI=1S/C19H16F4N6O2/c1-10(16-7-28(9-25-16)11-2-3-13(21)14(22)4-11)26-18-24-6-15(23)17(27-18)29-12(5-20)8-31-19(29)30/h2-4,6-7,9-10,12H,5,8H2,1H3,(H,24,26,27)/t10-,12-/m0/s1	VOPIQBRBHXRUFL-JQWIXIFHSA-N	247824	US10112931, Example 431::US9434719, 431 as TFA salt::US9688672, Example 431	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 47					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247824	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247824&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452086	346542363							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472324	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(Cl)c(F)c1	InChI=1S/C19H16ClF3N6O2/c1-10(16-7-28(9-25-16)11-2-3-13(20)14(22)4-11)26-18-24-6-15(23)17(27-18)29-12(5-21)8-31-19(29)30/h2-4,6-7,9-10,12H,5,8H2,1H3,(H,24,26,27)/t10-,12-/m0/s1	RJKUDZZRLBWLPG-JQWIXIFHSA-N	247825	US10112931, Example 432::US9434719, 432 as TFA salt::US9688672, Example 432	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 16					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247825	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247825&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452087	346542364							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472325	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(F)c(Cl)c1	InChI=1S/C19H16ClF3N6O2/c1-10(16-7-28(9-25-16)11-2-3-14(22)13(20)4-11)26-18-24-6-15(23)17(27-18)29-12(5-21)8-31-19(29)30/h2-4,6-7,9-10,12H,5,8H2,1H3,(H,24,26,27)/t10-,12-/m0/s1	NVVSKMGWOOUBRS-JQWIXIFHSA-N	247826	US10112931, Example 472::US9434719, 433 as TFA salt::US9434719, 472 as TFA salt::US9688672, Example 472	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 32					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247826	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247826&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415023	346542365							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472326	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(cc1)C(F)F	InChI=1S/C20H18F4N6O2/c1-11(16-8-29(10-26-16)13-4-2-12(3-5-13)17(23)24)27-19-25-7-15(22)18(28-19)30-14(6-21)9-32-20(30)31/h2-5,7-8,10-11,14,17H,6,9H2,1H3,(H,25,27,28)/t11-,14-/m0/s1	LNZPECKHDHOCTH-FZMZJTMJSA-N	247827	US10112931, Example 434::US9434719, 434 as TFA salt::US9688672, Example 434	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247827	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247827&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452088	346542366							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472327	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(C(F)F)c(F)c1	InChI=1S/C20H17F5N6O2/c1-10(16-7-30(9-27-16)11-2-3-13(17(24)25)14(22)4-11)28-19-26-6-15(23)18(29-19)31-12(5-21)8-33-20(31)32/h2-4,6-7,9-10,12,17H,5,8H2,1H3,(H,26,28,29)/t10-,12-/m0/s1	YEEAJLVWHWXJEY-JQWIXIFHSA-N	247828	US10112931, Example 435::US9434719, 435 as TFA salt::US9688672, Example 435	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247828	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247828&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452089	346542367							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472328	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1cc(F)cc(F)c1	InChI=1S/C19H16F4N6O2/c1-10(16-7-28(9-25-16)13-3-11(21)2-12(22)4-13)26-18-24-6-15(23)17(27-18)29-14(5-20)8-31-19(29)30/h2-4,6-7,9-10,14H,5,8H2,1H3,(H,24,26,27)/t10-,14-/m0/s1	JWXZESLECHVDLG-HZMBPMFUSA-N	247829	US10112931, Example 436::US9434719, 436 as TFA salt::US9688672, Example 436	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 60					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247829	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247829&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452090	346542368							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472329	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cc(on1)-c1ccc(Cl)cc1	InChI=1S/C19H16ClF2N5O3/c1-10(15-6-16(30-26-15)11-2-4-12(20)5-3-11)24-18-23-8-14(22)17(25-18)27-13(7-21)9-29-19(27)28/h2-6,8,10,13H,7,9H2,1H3,(H,23,24,25)/t10-,13-/m0/s1	AEANJYOKYOSHMJ-GWCFXTLKSA-N	247830	US10112931, Example 437::US9434719, 437 as TFA salt::US9688672, Example 437	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 36					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247830	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247830&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452091	346542369							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472330	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cnc(s1)-c1ccc(Cl)cc1	InChI=1S/C19H16ClF2N5O2S/c1-10(15-8-23-17(30-15)11-2-4-12(20)5-3-11)25-18-24-7-14(22)16(26-18)27-13(6-21)9-29-19(27)28/h2-5,7-8,10,13H,6,9H2,1H3,(H,24,25,26)/t10-,13-/m0/s1	JTVBEMFJLCUDSF-GWCFXTLKSA-N	247831	US10112931, Example 438::US9434719, 438 as TFA salt::US9688672, Example 438	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 45					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247831	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247831&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452092	346542370							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472331	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(c(C)n1)-c1ccc(Cl)cc1	InChI=1S/C20H19ClF2N6O2/c1-11(17-9-28(12(2)26-17)14-5-3-13(21)4-6-14)25-19-24-8-16(23)18(27-19)29-15(7-22)10-31-20(29)30/h3-6,8-9,11,15H,7,10H2,1-2H3,(H,24,25,27)/t11-,15-/m0/s1	KKBKZLBPYXMPHF-NHYWBVRUSA-N	247832	US10112931, Example 439::US9434719, 439 as TFA salt::US9688672, Example 439	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 392					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247832	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247832&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452093	346542371							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472332	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cnc(s1)-c1ccnc(F)c1	InChI=1S/C18H15F3N6O2S/c1-9(13-7-23-16(30-13)10-2-3-22-14(21)4-10)25-17-24-6-12(20)15(26-17)27-11(5-19)8-29-18(27)28/h2-4,6-7,9,11H,5,8H2,1H3,(H,24,25,26)/t9-,11-/m0/s1	LAVCAOAYAIPTIB-ONGXEEELSA-N	175671	US9688672, Example 440	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 172					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175671	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175671&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129286852	363892511							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472333	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cc(F)c(cc1F)-c1ccnc(C)c1	InChI=1S/C22H19F4N5O2/c1-11-5-13(3-4-27-11)16-7-17(24)15(6-18(16)25)12(2)29-21-28-9-19(26)20(30-21)31-14(8-23)10-33-22(31)32/h3-7,9,12,14H,8,10H2,1-2H3,(H,28,29,30)/t12-,14-/m0/s1	QUJSQKQTOGJSQE-JSGCOSHPSA-N	247834	US10112931, Example 441::US9434719, 441 as TFA salt::US9688672, Example 441	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247834	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247834&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452095	346542373							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472334	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cc(F)c(cc1F)-c1ccc(C)nc1	InChI=1S/C22H19F4N5O2/c1-11-3-4-13(8-27-11)16-6-17(24)15(5-18(16)25)12(2)29-21-28-9-19(26)20(30-21)31-14(7-23)10-33-22(31)32/h3-6,8-9,12,14H,7,10H2,1-2H3,(H,28,29,30)/t12-,14-/m0/s1	ZTPQMXHQHNRVHT-JSGCOSHPSA-N	247835	US10112931, Example 442::US9434719, 442 as TFA salt::US9688672, Example 442	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 38					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247835	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247835&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452096	346542374							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472335	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cc(F)c(cc1F)-c1ccc(nc1)C(F)(F)F	InChI=1S/C22H16F7N5O2/c1-10(32-20-31-8-17(26)19(33-20)34-12(6-23)9-36-21(34)35)13-4-16(25)14(5-15(13)24)11-2-3-18(30-7-11)22(27,28)29/h2-5,7-8,10,12H,6,9H2,1H3,(H,31,32,33)/t10-,12-/m0/s1	UJHALGOXSDSNLN-JQWIXIFHSA-N	247836	US10112931, Example 443::US9434719, 443 as TFA salt::US9688672, Example 443	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247836	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247836&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452097	346542375							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472336	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cc(F)c(cc1F)-c1ccnc(c1)C(F)(F)F	InChI=1S/C22H16F7N5O2/c1-10(32-20-31-8-17(26)19(33-20)34-12(7-23)9-36-21(34)35)13-5-16(25)14(6-15(13)24)11-2-3-30-18(4-11)22(27,28)29/h2-6,8,10,12H,7,9H2,1H3,(H,31,32,33)/t10-,12-/m0/s1	BUQIWBTXPVHMKM-JQWIXIFHSA-N	247837	US10112931, Example 444::US9434719, 444 as TFA salt::US9688672, Example 444	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247837	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247837&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452098	346542376							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472337	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cc(F)c(cc1F)-n1cnc(C)c1	InChI=1S/C20H18F4N6O2/c1-10-7-29(9-26-10)17-4-14(22)13(3-15(17)23)11(2)27-19-25-6-16(24)18(28-19)30-12(5-21)8-32-20(30)31/h3-4,6-7,9,11-12H,5,8H2,1-2H3,(H,25,27,28)/t11-,12-/m0/s1	WWELKOSMVLYQSW-RYUDHWBXSA-N	247838	US10112931, Example 445::US9434719, 445 as TFA salt::US9688672, Example 445	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 112					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247838	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247838&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452099	346542377							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472338	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(C(F)F)c(F)c2)ncc1F	InChI=1S/C21H19F5N6O2/c1-10(22)17-8-34-21(33)32(17)19-15(24)6-27-20(30-19)29-11(2)16-7-31(9-28-16)12-3-4-13(18(25)26)14(23)5-12/h3-7,9-11,17-18H,8H2,1-2H3,(H,27,29,30)/t10-,11-,17+/m0/s1	BRHQSNMICOTJLU-PSVSLLHZSA-N	247839	US10112931, Example 446::US9434719, 446 as TFA salt::US9688672, Example 446	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 27					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247839	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247839&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454455	346542378							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472339	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(cc2)C(F)F)ncc1F	InChI=1S/C21H20F4N6O2/c1-11(22)17-9-33-21(32)31(17)19-15(23)7-26-20(29-19)28-12(2)16-8-30(10-27-16)14-5-3-13(4-6-14)18(24)25/h3-8,10-12,17-18H,9H2,1-2H3,(H,26,28,29)/t11-,12-,17+/m0/s1	YZTROUKWLNOSAK-NVGCLXPQSA-N	247840	US10112931, Example 447::US9434719, 447 as TFA salt::US9688672, Example 447	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 28					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247840	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247840&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454433	346542379							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472340	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)c(F)c2)ncc1F	InChI=1S/C20H18ClF3N6O2/c1-10(22)17-8-32-20(31)30(17)18-15(24)6-25-19(28-18)27-11(2)16-7-29(9-26-16)12-3-4-13(21)14(23)5-12/h3-7,9-11,17H,8H2,1-2H3,(H,25,27,28)/t10-,11-,17+/m0/s1	BWMXYVHTSYLXNW-PSVSLLHZSA-N	247841	US10112931, Example 448::US9434719, 448 as TFA salt::US9688672, Example 448	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247841	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247841&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454343	346542380							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472341	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2cc(F)cc(F)c2)ncc1F	InChI=1S/C20H18F4N6O2/c1-10(21)17-8-32-20(31)30(17)18-15(24)6-25-19(28-18)27-11(2)16-7-29(9-26-16)14-4-12(22)3-13(23)5-14/h3-7,9-11,17H,8H2,1-2H3,(H,25,27,28)/t10-,11-,17+/m0/s1	SHUACSXYCKAFCG-PSVSLLHZSA-N	247842	US10112931, Example 449::US9434719, 449 as TFA salt::US9688672, Example 449	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 30					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247842	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247842&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454357	346542381							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472342	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C20H19ClF2N6O2/c1-11(22)17-9-31-20(30)29(17)18-15(23)7-24-19(27-18)26-12(2)16-8-28(10-25-16)14-5-3-13(21)4-6-14/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)/t11-,12-,17+/m0/s1	TXJIZORMCOMGCK-NVGCLXPQSA-N	247843	US10112931, Example 450::US9434719, 450 as TFA salt::US9688672, Example 450	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247843	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247843&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454346	346542382							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472343	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(F)cc2)ncc1F	InChI=1S/C20H19F3N6O2/c1-11(21)17-9-31-20(30)29(17)18-15(23)7-24-19(27-18)26-12(2)16-8-28(10-25-16)14-5-3-13(22)4-6-14/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)/t11-,12-,17+/m0/s1	XSQQJNHGJYGXLX-NVGCLXPQSA-N	247844	US10112931, Example 451::US9434719, 451 as TFA salt::US9688672, Example 451	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 44					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247844	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247844&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454320	346542383							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472344	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C20H18ClF2N5O3/c1-10(22)16-9-30-20(29)28(16)18-14(23)8-24-19(26-18)25-11(2)15-7-17(31-27-15)12-3-5-13(21)6-4-12/h3-8,10-11,16H,9H2,1-2H3,(H,24,25,26)/t10-,11-,16+/m0/s1	KPUWPLMVSGVTML-XMZIXOGTSA-N	247845	US10112931, Example 452::US9434719, 452 as TFA salt::US9688672, Example 452	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247845	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247845&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454348	346542384							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472345	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)ncc1F	InChI=1S/C20H19ClF2N6O2/c1-11(22)17-10-31-20(30)29(17)18-16(23)8-24-19(27-18)26-12(2)13-7-25-28(9-13)15-5-3-14(21)4-6-15/h3-9,11-12,17H,10H2,1-2H3,(H,24,26,27)/t11-,12-,17+/m0/s1	YFWQMXWNYLZFPV-NVGCLXPQSA-N	247846	US10112931, Example 453::US9434719, 453 as TFA salt::US9688672, Example 453	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 36					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247846	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247846&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454344	346542385							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472346	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2cc(F)cc(F)c2)n1	InChI=1S/C20H19F3N6O2/c1-11(21)17-9-31-20(30)29(17)18-3-4-24-19(27-18)26-12(2)16-8-28(10-25-16)15-6-13(22)5-14(23)7-15/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)/t11-,12-,17+/m0/s1	XXNNSQAHQANGNY-NVGCLXPQSA-N	247847	US10112931, Example 454::US9434719, 454 as TFA salt::US9688672, Example 454	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 23					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247847	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247847&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454345	346542386							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472347	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(C(F)F)c(F)c2)n1	InChI=1S/C21H20F4N6O2/c1-11(22)17-9-33-21(32)31(17)18-5-6-26-20(29-18)28-12(2)16-8-30(10-27-16)13-3-4-14(19(24)25)15(23)7-13/h3-8,10-12,17,19H,9H2,1-2H3,(H,26,28,29)/t11-,12-,17+/m0/s1	NAOADSREFWJWOH-NVGCLXPQSA-N	247848	US10112931, Example 455::US9434719, 455 as TFA salt::US9688672, Example 455	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247848	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247848&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454425	346542387							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472348	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(cc2)C(F)F)n1	InChI=1S/C21H21F3N6O2/c1-12(22)17-10-32-21(31)30(17)18-7-8-25-20(28-18)27-13(2)16-9-29(11-26-16)15-5-3-14(4-6-15)19(23)24/h3-9,11-13,17,19H,10H2,1-2H3,(H,25,27,28)/t12-,13-,17+/m0/s1	RJYKUROAIMWHTJ-GDZNZVCISA-N	247849	US10112931, Example 456::US9434719, 456::US9688672, Example 456	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247849	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247849&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454349	346542388							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472349	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(cc2)C(F)F)n1	InChI=1S/C21H21F3N6O2/c1-12(22)17-10-32-21(31)30(17)18-7-8-25-20(28-18)27-13(2)16-9-29(11-26-16)15-5-3-14(4-6-15)19(23)24/h3-9,11-13,17,19H,10H2,1-2H3,(H,25,27,28)/t12-,13-,17+/m0/s1	RJYKUROAIMWHTJ-GDZNZVCISA-N	247849	US10112931, Example 456::US9434719, 456::US9688672, Example 456	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1.00					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247849	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247849&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454349	346542388							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472350	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(F)c(Cl)c2)n1	InChI=1S/C20H19ClF2N6O2/c1-11(22)17-9-31-20(30)29(17)18-5-6-24-19(27-18)26-12(2)16-8-28(10-25-16)13-3-4-15(23)14(21)7-13/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)/t11-,12-,17+/m0/s1	SUNCNPZABKTXGR-NVGCLXPQSA-N	247850	US10112931, Example 457::US9434719, 457 as TFA salt::US9688672, Example 457	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247850	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247850&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454350	346542389							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472351	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)c(F)c2)n1	InChI=1S/C20H19ClF2N6O2/c1-11(22)17-9-31-20(30)29(17)18-5-6-24-19(27-18)26-12(2)16-8-28(10-25-16)13-3-4-14(21)15(23)7-13/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)/t11-,12-,17+/m0/s1	VTNGUBXZQCZZRS-NVGCLXPQSA-N	247851	US10112931, Example 458::US9434719, 458 as TFA salt::US9688672, Example 458	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247851	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247851&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454319	346542390							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472352	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(F)c(F)c2)n1	InChI=1S/C20H19F3N6O2/c1-11(21)17-9-31-20(30)29(17)18-5-6-24-19(27-18)26-12(2)16-8-28(10-25-16)13-3-4-14(22)15(23)7-13/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)/t11-,12-,17+/m0/s1	BVIGUFPJCYRDKX-NVGCLXPQSA-N	247852	US10112931, Example 459::US9434719, 459 as TFA salt::US9688672, Example 459	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 25					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247852	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247852&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454359	346542391							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472353	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-c2cnn(C)c2)n1	InChI=1S/C21H21F3N6O2/c1-11(22)18-10-32-21(31)30(18)19-4-5-25-20(28-19)27-12(2)14-6-17(24)15(7-16(14)23)13-8-26-29(3)9-13/h4-9,11-12,18H,10H2,1-3H3,(H,25,27,28)/t11-,12-,18+/m0/s1	PRQTXEWKEGXZSP-OAVHHTNSSA-N	247853	US10112931, Example 460::US9434719, 460 as TFA salt::US9688672, Example 460	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 34					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247853	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247853&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454347	346542392							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472354	C[C@@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(F)cc2)ncc1F	InChI=1S/C20H19F3N6O2/c1-11(21)17-9-31-20(30)29(17)18-15(23)7-24-19(27-18)26-12(2)16-8-28(10-25-16)14-5-3-13(22)4-6-14/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)/t11-,12+,17-/m1/s1	XSQQJNHGJYGXLX-BWACUDIHSA-N	247854	US10112931, Example 461::US9434719, 461 as TFA salt::US9688672, Example 461	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 54					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247854	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247854&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452100	346542393							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472355	C[C@@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ncc(cc2F)-c2ccnc(c2)C(F)(F)F)ncc1F	InChI=1S/C22H18F6N6O2/c1-10(23)16-9-36-21(35)34(16)19-15(25)8-31-20(33-19)32-11(2)18-14(24)5-13(7-30-18)12-3-4-29-17(6-12)22(26,27)28/h3-8,10-11,16H,9H2,1-2H3,(H,31,32,33)/t10-,11+,16-/m1/s1	RZJWJDQMMZKFDZ-OHUAYANFSA-N	247855	US10112931, Example 462::US9434719, 462 as TFA salt::US9688672, Example 462	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 74					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247855	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247855&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452101	346542394							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472356	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cc2F)-c2ccnc(c2)C(F)(F)F)n1	InChI=1S/C22H19F5N6O2/c1-11(23)16-10-35-21(34)33(16)18-4-6-29-20(32-18)31-12(2)19-15(24)7-14(9-30-19)13-3-5-28-17(8-13)22(25,26)27/h3-9,11-12,16H,10H2,1-2H3,(H,29,31,32)/t11-,12-,16+/m0/s1	IOIQVLOYWKIJAZ-MQIPJXDCSA-N	247856	US10112931, Example 463::US9434719, 463::US9688672, Example 463	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 38					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247856	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247856&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452102	346542395							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472357	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cc2F)-c2ccnc(c2)C(F)(F)F)n1	InChI=1S/C22H19F5N6O2/c1-11(23)16-10-35-21(34)33(16)18-4-6-29-20(32-18)31-12(2)19-15(24)7-14(9-30-19)13-3-5-28-17(8-13)22(25,26)27/h3-9,11-12,16H,10H2,1-2H3,(H,29,31,32)/t11-,12-,16+/m0/s1	IOIQVLOYWKIJAZ-MQIPJXDCSA-N	247856	US10112931, Example 463::US9434719, 463::US9688672, Example 463	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 38					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247856	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247856&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452102	346542395							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472358	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cc2F)-c2ccnc(c2)C(F)(F)F)n1	InChI=1S/C22H19F5N6O2/c1-11(23)16-10-35-21(34)33(16)18-4-6-29-20(32-18)31-12(2)19-15(24)7-14(9-30-19)13-3-5-28-17(8-13)22(25,26)27/h3-9,11-12,16H,10H2,1-2H3,(H,29,31,32)/t11-,12+,16-/m1/s1	IOIQVLOYWKIJAZ-BFQNTYOBSA-N	247857	US10112931, Example 464::US9434719, 464 as TFA salt::US9688672, Example 464	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 94					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247857	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247857&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452103	346542396							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472359	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ncc(cc2F)-c2ccnc(c2)C(F)(F)F)ncc1F	InChI=1S/C22H18F6N6O2/c1-10(23)16-9-36-21(35)34(16)19-15(25)8-31-20(33-19)32-11(2)18-14(24)5-13(7-30-18)12-3-4-29-17(6-12)22(26,27)28/h3-8,10-11,16H,9H2,1-2H3,(H,31,32,33)/t10-,11-,16+/m0/s1	RZJWJDQMMZKFDZ-XMZIXOGTSA-N	247858	US10112931, Example 465::US9434719, 465 as TFA salt::US9688672, Example 465	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 68					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247858	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247858&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452104	346542397							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472360	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(C)c(cn2)-c2ccnc(c2)C(F)(F)F)n1	InChI=1S/C23H22F4N6O2/c1-12-8-17(30-10-16(12)15-4-6-28-19(9-15)23(25,26)27)14(3)31-21-29-7-5-20(32-21)33-18(13(2)24)11-35-22(33)34/h4-10,13-14,18H,11H2,1-3H3,(H,29,31,32)/t13-,14-,18+/m0/s1	DCGDPJCUIKLTDU-SUNYJGFJSA-N	247859	US10112931, Example 466::US9434719, 466::US9688672, Example 466	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 26					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247859	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247859&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	C81	6B0Z	90415637	346542398							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472361	C[C@H](F)C1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cn2)-c2cccc(c2F)C(F)(F)F)n1	InChI=1S/C22H19F5N6O2/c1-11(23)16-10-35-21(34)33(16)17-6-7-28-20(32-17)31-12(2)19-29-8-13(9-30-19)14-4-3-5-15(18(14)24)22(25,26)27/h3-9,11-12,16H,10H2,1-2H3,(H,28,31,32)/t11-,12-,16?/m0/s1	GRLDXWXKPBGGFY-YSWZKLOHSA-N	247860	US9434719, 467::US9688672, Example 467	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 9.00					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247860	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247860&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416568	346542399							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472362	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2ccnc(c2)C(F)(F)F)n1	InChI=1S/C22H20F4N6O2/c1-12(23)17-11-34-21(33)32(17)19-6-8-28-20(31-19)30-13(2)16-4-3-15(10-29-16)14-5-7-27-18(9-14)22(24,25)26/h3-10,12-13,17H,11H2,1-2H3,(H,28,30,31)/t12-,13-,17+/m0/s1	CRWAIFFIPSZEKI-GDZNZVCISA-N	247861	US10112931, Example 468::US9434719, 468::US9688672, Example 468	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 128					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247861	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247861&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416189	346542400							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472363	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cn2)-c2ccc(F)c(C)c2)n1	InChI=1S/C22H22F2N6O2/c1-12-8-15(4-5-17(12)24)16-9-26-20(27-10-16)14(3)28-21-25-7-6-19(29-21)30-18(13(2)23)11-32-22(30)31/h4-10,13-14,18H,11H2,1-3H3,(H,25,28,29)/t13-,14-,18+/m0/s1	RYLRLADEFFZKLS-SUNYJGFJSA-N	247862	US10112931, Example 469::US9434719, 469::US9688672, Example 469	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247862	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247862&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416226	346542401							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472364	C[C@H](Nc1nccc(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(F)cc1	InChI=1S/C19H18F2N6O2/c1-12(16-9-26(11-23-16)14-4-2-13(21)3-5-14)24-18-22-7-6-17(25-18)27-15(8-20)10-29-19(27)28/h2-7,9,11-12,15H,8,10H2,1H3,(H,22,24,25)/t12-,15-/m0/s1	MUJQDKNKSGDIBR-WFASDCNBSA-N	247864	US10112931, Example 471::US9434719, 471 as TFA salt::US9688672, Example 471	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 49					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247864	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247864&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90417235	346542403							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472365	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(F)c(Cl)c1	InChI=1S/C19H16ClF3N6O2/c1-10(16-7-28(9-25-16)11-2-3-14(22)13(20)4-11)26-18-24-6-15(23)17(27-18)29-12(5-21)8-31-19(29)30/h2-4,6-7,9-10,12H,5,8H2,1H3,(H,24,26,27)/t10-,12-/m0/s1	NVVSKMGWOOUBRS-JQWIXIFHSA-N	247826	US10112931, Example 472::US9434719, 433 as TFA salt::US9434719, 472 as TFA salt::US9688672, Example 472	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 32					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247826	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247826&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415023	346542365							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472366	C[C@H](Nc1nccc(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(Cl)c(F)c1	InChI=1S/C19H17ClF2N6O2/c1-11(16-8-27(10-24-16)12-2-3-14(20)15(22)6-12)25-18-23-5-4-17(26-18)28-13(7-21)9-30-19(28)29/h2-6,8,10-11,13H,7,9H2,1H3,(H,23,25,26)/t11-,13-/m0/s1	KAGPKBJIFWYNFG-AAEUAGOBSA-N	247866	US10112931, Example 473::US9434719, 473 as TFA salt::US9688672, Example 473	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 19					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247866	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247866&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416762	346542404							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472367	C[C@H](Nc1nccc(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(F)c(F)c1	InChI=1S/C19H17F3N6O2/c1-11(16-8-27(10-24-16)12-2-3-14(21)15(22)6-12)25-18-23-5-4-17(26-18)28-13(7-20)9-30-19(28)29/h2-6,8,10-11,13H,7,9H2,1H3,(H,23,25,26)/t11-,13-/m0/s1	CCFPSGAPMCORJU-AAEUAGOBSA-N	247867	US10112931, Example 474::US9434719, 474 as TFA salt::US9688672, Example 474	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 77					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247867	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247867&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90417093	346542405							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472368	C[C@H](Nc1nccc(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(C(F)F)c(F)c1	InChI=1S/C20H18F4N6O2/c1-11(16-8-29(10-26-16)12-2-3-14(18(23)24)15(22)6-12)27-19-25-5-4-17(28-19)30-13(7-21)9-32-20(30)31/h2-6,8,10-11,13,18H,7,9H2,1H3,(H,25,27,28)/t11-,13-/m0/s1	KQAQIPGOQYGYGU-AAEUAGOBSA-N	247868	US10112931, Example 475::US9434719, 475 as TFA salt::US9688672, Example 475	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 22					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247868	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247868&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414573	346542406							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472369	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2F)n1	InChI=1S/C20H19ClF2N6O2/c1-11(22)17-9-31-20(30)29(17)18-5-6-24-19(27-18)26-12(2)15-8-28(10-25-15)16-4-3-13(21)7-14(16)23/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)/t11-,12-,17+/m0/s1	GBVGVZWPJUJRID-NVGCLXPQSA-N	247869	US10112931, Example 476::US9434719, 476 as TFA salt::US9688672, Example 476	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247869	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247869&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415785	346542407							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472370	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2F)ncc1F	InChI=1S/C20H18ClF3N6O2/c1-10(22)17-8-32-20(31)30(17)18-14(24)6-25-19(28-18)27-11(2)15-7-29(9-26-15)16-4-3-12(21)5-13(16)23/h3-7,9-11,17H,8H2,1-2H3,(H,25,27,28)/t10-,11-,17+/m0/s1	LOFZHNKWHDCFGV-PSVSLLHZSA-N	247870	US10112931, Example 477::US9434719, 477::US9688672, Example 477	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247870	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247870&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90417032	346542408							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472371	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(F)cc2F)n1	InChI=1S/C20H19F3N6O2/c1-11(21)17-9-31-20(30)29(17)18-5-6-24-19(27-18)26-12(2)15-8-28(10-25-15)16-4-3-13(22)7-14(16)23/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)/t11-,12-,17+/m0/s1	QSXVHTSSRYSMHW-NVGCLXPQSA-N	247871	US10112931, Example 478::US9434719, 478 as TFA salt::US9688672, Example 478	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 51					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247871	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247871&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414670	346542409							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472372	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(F)cc2F)ncc1F	InChI=1S/C20H18F4N6O2/c1-10(21)17-8-32-20(31)30(17)18-14(24)6-25-19(28-18)27-11(2)15-7-29(9-26-15)16-4-3-12(22)5-13(16)23/h3-7,9-11,17H,8H2,1-2H3,(H,25,27,28)/t10-,11-,17+/m0/s1	JVMVIFQILNOBFI-PSVSLLHZSA-N	247872	US10112931, Example 479::US9434719, 479 as TFA salt::US9688672, Example 479	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 87					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247872	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247872&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416756	346542410							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
472373	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1ncc(o1)-c1ccc(Cl)cc1	InChI=1S/C19H16ClF2N5O3/c1-10(17-23-8-15(30-17)11-2-4-12(20)5-3-11)25-18-24-7-14(22)16(26-18)27-13(6-21)9-29-19(27)28/h2-5,7-8,10,13H,6,9H2,1H3,(H,24,25,26)/t10-,13-/m0/s1	SDTNROJHSVEFHF-GWCFXTLKSA-N	247873	US10112931, Example 480::US9434719, 480::US9688672, Example 480	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17					7.5	25.00 C	US Patent		10.7270/Q2251GBM		aid1794982	US9688672	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	6/27/2017	3/19/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247873	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247873&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90423199	346542411							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529890	CC1(COC1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H17Cl3N2O5/c1-25(11-34-12-25)23-21(22(29-35-23)20-16(27)9-14(26)10-17(20)28)24(33)30-8-7-15-13(5-6-19(31)32)3-2-4-18(15)30/h2-10H,11-12H2,1H3,(H,31,32)/b6-5+	GUUIMFGRPPTLFX-AATRIKPKSA-N	278539	(2E)-3-(1-{[5-(3-Methyloxetan-3-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10.00					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278539	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278539&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130306974	378160133							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529892	Cc1cn(C(=O)c2c(noc2C2(C)COC2)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H19Cl3N2O5/c1-13-10-31(18-5-3-4-14(20(13)18)6-7-19(32)33)25(34)22-23(21-16(28)8-15(27)9-17(21)29)30-36-24(22)26(2)11-35-12-26/h3-10H,11-12H2,1-2H3,(H,32,33)/b7-6+	HYWBLOXYWSBDNM-VOTSOKGWSA-N	278540	 (2E)-3-(3-Methyl-1-{[5-(3-methyloxetan-3-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7.00					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278540	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278540&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307051	378160134							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529894	COC1(COC1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H17Cl3N2O6/c1-34-25(11-35-12-25)23-21(22(29-36-23)20-16(27)9-14(26)10-17(20)28)24(33)30-8-7-15-13(5-6-19(31)32)3-2-4-18(15)30/h2-10H,11-12H2,1H3,(H,31,32)/b6-5+	STYBXRKGHGFUHP-AATRIKPKSA-N	278541	 (2E)-3-(1-{[5-(3-Methoxyoxetan-3-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 3	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7.00					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278541	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278541&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307131	378160135							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529896	COC1(COC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C26H19Cl3N2O6/c1-13-10-31(18-5-3-4-14(20(13)18)6-7-19(32)33)25(34)22-23(21-16(28)8-15(27)9-17(21)29)30-37-24(22)26(35-2)11-36-12-26/h3-10H,11-12H2,1-2H3,(H,32,33)/b7-6+	LEFPHBUXKVVVQR-VOTSOKGWSA-N	278542	 (2E)-3-(1-{[5-(3-Methoxyoxetan-3-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 8.00					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278542	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278542&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307233	378160136							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529898	CCC1(COC1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C26H20Cl2N2O5/c1-2-26(13-34-14-26)24-22(23(29-35-24)21-17(27)6-4-7-18(21)28)25(33)30-12-11-16-15(9-10-20(31)32)5-3-8-19(16)30/h3-12H,2,13-14H2,1H3,(H,31,32)/b10-9+	XEODONMEYPNKSS-MDZDMXLPSA-N	278543	 (2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(3-ethyloxetan-3-yl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278543	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278543&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307317	378160137							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529900	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(noc1C1(F)COC1)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C24H14Cl3FN2O5/c25-13-8-15(26)19(16(27)9-13)21-20(22(35-29-21)24(28)10-34-11-24)23(33)30-7-6-14-12(4-5-18(31)32)2-1-3-17(14)30/h1-9H,10-11H2,(H,31,32)/b5-4+	TZFJDMKNEHTWGX-SNAWJCMRSA-N	278544	 (2E)-3-(1-{[5-(3-Fluorooxetan-3-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 6	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278544	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278544&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307129	378160138							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529902	CC(C)(O)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C24H18Cl2N2O5/c1-24(2,32)22-20(21(27-33-22)19-15(25)6-4-7-16(19)26)23(31)28-12-11-14-13(9-10-18(29)30)5-3-8-17(14)28/h3-12,32H,1-2H3,(H,29,30)/b10-9+	QCJZHAYRCPMVBV-MDZDMXLPSA-N	278545	 (2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(2-hydroxypropan-2-yl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278545	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278545&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307053	378160139							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529904	CC1(COC1)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C27H19Cl3N2O5/c1-27(11-36-12-27)25-23(24(31-37-25)22-17(29)8-15(28)9-18(22)30)26(35)32-10-14-6-5-13(7-20(33)34)16-3-2-4-19(32)21(14)16/h2-4,7-10H,5-6,11-12H2,1H3,(H,33,34)/b13-7+	YTFZGEAFVYSQNL-NTUHNPAUSA-N	278546	 (2E)-[1-{[5-(3-Methyloxetan-3-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzo[cd]indol-5(1H)-ylidene]ethanoic acid  ::US10040791, Example 8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 8.00					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278546	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278546&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307130	378160140							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529906	CC1(COC1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)ccnc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C24H16Cl3N3O5/c1-24(10-34-11-24)21-19(20(29-35-21)18-15(26)8-13(25)9-16(18)27)23(33)30-7-5-14-12(2-3-17(31)32)4-6-28-22(14)30/h2-9H,10-11H2,1H3,(H,31,32)/b3-2+	QXJHSRNWHJVTFC-NSCUHMNNSA-N	278547	 (2E)-3-(1-{[5-(3-Methyloxetan-3-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-pyrrolo[2,3-b]pyridin-4-yl]prop-2-enoic acid   ::US10040791, Example 9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 28					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278547	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278547&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130306978	378160141							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529908	Cc1cn(C(=O)c2c(noc2C2(C)CCC2)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C27H21Cl3N2O4/c1-14-13-32(19-6-3-5-15(21(14)19)7-8-20(33)34)26(35)23-24(22-17(29)11-16(28)12-18(22)30)31-36-25(23)27(2)9-4-10-27/h3,5-8,11-13H,4,9-10H2,1-2H3,(H,33,34)/b8-7+	QHSJEYJOBOUGEC-BQYQJAHWSA-N	278548	(2E)-3-(3-Methyl-1-{[5-(1-methylcyclobutyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 10	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278548	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278548&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307235	378160142							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529910	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cncc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C24H18Cl2FN3O4/c1-12-11-30(16-6-4-5-13(18(12)16)7-8-17(31)32)23(33)20-21(29-34-22(20)24(2,3)27)19-14(25)9-28-10-15(19)26/h4-11H,1-3H3,(H,31,32)/b8-7+	UHDGEPDZTMAVJV-BQYQJAHWSA-N	278549	 (2E)-3-(1-{[3-(3,5-Dichloropyridin-2-yl)-5-(2-fluoropropan-2-yl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 13					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278549	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278549&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307132	378160143							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529912	COC1(CCC1)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C28H21Cl3N2O5/c1-37-28(8-3-9-28)26-24(25(32-38-26)23-18(30)11-16(29)12-19(23)31)27(36)33-13-15-7-6-14(10-21(34)35)17-4-2-5-20(33)22(15)17/h2,4-5,10-13H,3,6-9H2,1H3,(H,34,35)/b14-10+	CAZZHNDDRFPVJL-GXDHUFHOSA-N	278550	 (2E)-[1-{[5-(1-Methoxycyclobutyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzo[cd]indol-5(1H)-::US10040791, Example 12	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 16					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278550	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278550&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307052	378160144							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529914	CC(C)(F)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C26H18Cl3FN2O4/c1-26(2,30)24-22(23(31-36-24)21-16(28)9-14(27)10-17(21)29)25(35)32-11-13-7-6-12(8-19(33)34)15-4-3-5-18(32)20(13)15/h3-5,8-11H,6-7H2,1-2H3,(H,33,34)/b12-8+	MVIGZMHMDFYACG-XYOKQWHBSA-N	278551	 (2E)-[1-{[5-(2-Fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzop[cd]indol-5(1H)-ylidene]ethanoic acid  ::US10040791, Example 13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278551	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278551&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307134	378160145							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529916	COC1(CCC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(F)cc(Cl)cc1Cl	InChI=1S/C27H21Cl2FN2O5/c1-14-13-32(19-6-3-5-15(21(14)19)7-8-20(33)34)26(35)23-24(22-17(29)11-16(28)12-18(22)30)31-37-25(23)27(36-2)9-4-10-27/h3,5-8,11-13H,4,9-10H2,1-2H3,(H,33,34)/b8-7+	HCJBIQJBHNAGCT-BQYQJAHWSA-N	278552	 (2E)-3-(1-{[3-(2,4-Dichloro-6-fluorophenyl)-5-(1-methoxycyclobutyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl]prop-2-enoic acid  ::US10040791, Example 14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278552	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278552&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130306979	378160146							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529918	COC1(CCC1)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(F)cc(Cl)cc1Cl	InChI=1S/C28H21Cl2FN2O5/c1-37-28(8-3-9-28)26-24(25(32-38-26)23-18(30)11-16(29)12-19(23)31)27(36)33-13-15-7-6-14(10-21(34)35)17-4-2-5-20(33)22(15)17/h2,4-5,10-13H,3,6-9H2,1H3,(H,34,35)/b14-10+	KXHHUBQLBSPFKX-GXDHUFHOSA-N	278553	 (2E)-[1-{[3-(2,4-Dichloro-6-fluorophenyl)-5-(1-methoxycyclobutyl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzo[cd]indol-5(1H)-::US10040791, Example 15	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278553	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278553&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130306981	378160147							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529920	CC(C)(F)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(F)cc(Cl)cc1Cl	InChI=1S/C26H18Cl2F2N2O4/c1-26(2,30)24-22(23(31-36-24)21-16(28)9-14(27)10-17(21)29)25(35)32-11-13-7-6-12(8-19(33)34)15-4-3-5-18(32)20(13)15/h3-5,8-11H,6-7H2,1-2H3,(H,33,34)/b12-8+	KKYRFHWXZPWGSG-XYOKQWHBSA-N	278554	 (2E)-[1-{[3-(2,4-Dichloro-6-fluorophenyl)-5-(2-fluoropropan-2-yl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzo[cd]indol-5(1H)-::US10040791, Example 16	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 15					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278554	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278554&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307324	378160148							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529922	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2ccc(Cl)c(F)c2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H18Cl2F2N2O4/c1-12-11-31(16-6-4-5-13(18(12)16)7-10-17(32)33)24(34)19-22(30-35-23(19)25(2,3)29)14-8-9-15(26)21(28)20(14)27/h4-11H,1-3H3,(H,32,33)/b10-7+	CASAMGIMEQMXAY-JXMROGBWSA-N	278555	 (2E)-3-(1-{[3-(2,4-Dichloro-3-fluorophenyl-5-(2-fluoropropan-2-yl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 17	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 24					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278555	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278555&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307322	378160149							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529924	CC(C)(F)c1onc(c1C(=O)n1ccc2c3CC(CCc3ccc12)C(O)=O)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C26H20Cl3FN2O4/c1-26(2,30)23-21(22(31-36-23)20-17(28)10-14(27)11-18(20)29)24(33)32-8-7-15-16-9-13(25(34)35)4-3-12(16)5-6-19(15)32/h5-8,10-11,13H,3-4,9H2,1-2H3,(H,34,35)	HAFXELMPPKAVQF-UHFFFAOYSA-N	278556	 3-{[5-(2-Fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-6,7,8,9-tetrahydro-3H-Benzo[e]indole-8-carboxylic acid  ::US10040791, Example 18	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 19					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278556	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278556&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307237	378160150							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529926	CC1(CC(F)(F)C1)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C28H19Cl3F2N2O4/c1-27(11-28(32,33)12-27)25-23(24(34-39-25)22-17(30)8-15(29)9-18(22)31)26(38)35-10-14-6-5-13(7-20(36)37)16-3-2-4-19(35)21(14)16/h2-4,7-10H,5-6,11-12H2,1H3,(H,36,37)/b13-7+	RXFMFDIZFGQVGG-NTUHNPAUSA-N	278557	 (2E)-[1-{[5-(3,3-Difluoro-1-methylcyclobutyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3,4-::US10040791, Example 19	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 16					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278557	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278557&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307135	378160151							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529928	CC(C)(F)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1ccc(Cl)c(F)c1Cl	InChI=1S/C26H18Cl2F2N2O4/c1-26(2,30)24-20(23(31-36-24)15-8-9-16(27)22(29)21(15)28)25(35)32-11-13-7-6-12(10-18(33)34)14-4-3-5-17(32)19(13)14/h3-5,8-11H,6-7H2,1-2H3,(H,33,34)/b12-10+	LGQXUYAGLCRTRI-ZRDIBKRKSA-N	278558	 (2E)-[1-{[3-(2,4-Dichloro-3-fluorophenyl)-5-(2-fluoropropan-2-yl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzo[cd]indol-5(1H)-::US10040791, Example 20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 27					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278558	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278558&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307321	378160152							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529930	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H18Cl3FN2O4/c1-12-11-31(17-6-4-5-13(19(12)17)7-8-18(32)33)24(34)21-22(30-35-23(21)25(2,3)29)20-15(27)9-14(26)10-16(20)28/h4-11H,1-3H3,(H,32,33)/b8-7+	BOOMBLZEOHXPPX-BQYQJAHWSA-N	278559	(2E)-3-(1-{[5-(2-Fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278559	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278559&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	7SU	7PJN	130306983	378160153							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529932	CC(C)(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H19Cl3N2O4/c1-25(2,3)23-21(22(29-34-23)20-16(27)11-14(26)12-17(20)28)24(33)30-10-9-15-13(7-8-19(31)32)5-4-6-18(15)30/h4-12H,1-3H3,(H,31,32)/b8-7+	LCOBXWZHLGWJIZ-BQYQJAHWSA-N	278560	 (2E)-3-(1-{[5-(tert-Butyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 31					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278560	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278560&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307054	378160154							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529934	CC(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C24H18Cl2N2O4/c1-13(2)23-21(22(27-32-23)20-16(25)6-4-7-17(20)26)24(31)28-12-11-15-14(9-10-19(29)30)5-3-8-18(15)28/h3-13H,1-2H3,(H,29,30)/b10-9+	KADGEUCPGOYAHO-MDZDMXLPSA-N	278561	 (2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 23	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 6.00					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278561	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278561&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307133	378160155							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529936	CC(C)(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C25H20Cl2N2O4/c1-25(2,3)23-21(22(28-33-23)20-16(26)7-5-8-17(20)27)24(32)29-13-12-15-14(10-11-19(30)31)6-4-9-18(15)29/h4-13H,1-3H3,(H,30,31)/b11-10+	PTWCGRGZFAKIRK-ZHACJKMWSA-N	278562	 (2E)-3-(1-{[5-(tert-Butyl)-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 24	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 30					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278562	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278562&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307323	378160156							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529938	CC(C)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C25H20Cl2N2O4/c1-13(2)24-22(23(28-33-24)21-16(26)7-5-8-17(21)27)25(32)29-12-14(3)20-15(10-11-19(30)31)6-4-9-18(20)29/h4-13H,1-3H3,(H,30,31)/b11-10+	RRZHMFYRBCZLQU-ZHACJKMWSA-N	278563	 (2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 25	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 30					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278563	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278563&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307055	378160157							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529940	CC(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C24H17Cl3N2O4/c1-12(2)23-21(22(28-33-23)20-16(26)10-14(25)11-17(20)27)24(32)29-9-8-15-13(6-7-19(30)31)4-3-5-18(15)29/h3-12H,1-2H3,(H,30,31)/b7-6+	HJZWUPUKQAOZOL-VOTSOKGWSA-N	278564	 (2E)-3-(1-{[5-(Propan-2-yl)-3-(2,4,6-Trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 38					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278564	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278564&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307240	378160158							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529942	COC(C)(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C25H20Cl2N2O5/c1-25(2,33-3)23-21(22(28-34-23)20-16(26)7-5-8-17(20)27)24(32)29-13-12-15-14(10-11-19(30)31)6-4-9-18(15)29/h4-13H,1-3H3,(H,30,31)/b11-10+	RBYMZTGYWZYCGQ-ZHACJKMWSA-N	278565	 (2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(2-methoxypropan-2-yl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278565	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278565&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307140	378160159							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529944	CC(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)ccc(F)c1Cl	InChI=1S/C24H17Cl2FN2O4/c1-12(2)23-20(22(28-33-23)19-15(25)7-8-16(27)21(19)26)24(32)29-11-10-14-13(6-9-18(30)31)4-3-5-17(14)29/h3-12H,1-2H3,(H,30,31)/b9-6+	CEZDLRBULRMOMM-RMKNXTFCSA-N	278566	 (2E)-3-(1-{[3-(2,6-Dichloro-3-fluorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 28	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 8.00					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278566	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278566&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130306985	378160160							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529946	CC(C)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H19Cl3N2O4/c1-12(2)24-22(23(29-34-24)21-16(27)9-15(26)10-17(21)28)25(33)30-11-13(3)20-14(7-8-19(31)32)5-4-6-18(20)30/h4-12H,1-3H3,(H,31,32)/b8-7+	MNHSYSZAEPPKAS-BQYQJAHWSA-N	278567	 (2E)-3-(1-{[5-(Propan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278567	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278567&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130306988	378160161							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529948	CC(C)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)ccc(F)c1Cl	InChI=1S/C25H19Cl2FN2O4/c1-12(2)24-21(23(29-34-24)20-15(26)8-9-16(28)22(20)27)25(33)30-11-13(3)19-14(7-10-18(31)32)5-4-6-17(19)30/h4-12H,1-3H3,(H,31,32)/b10-7+	TXSKIZGFRWQAPI-JXMROGBWSA-N	278568	 (2E)-3-(1-{[3-(2,6-Dichloro-3-fluorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 30	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278568	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278568&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130306986	378160162							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529950	COC(C)(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H19Cl3N2O5/c1-25(2,34-3)23-21(22(29-35-23)20-16(27)11-14(26)12-17(20)28)24(33)30-10-9-15-13(7-8-19(31)32)5-4-6-18(15)30/h4-12H,1-3H3,(H,31,32)/b8-7+	NEJDEYZFTDRNEU-BQYQJAHWSA-N	278569	 (2E)-3-(1-{[5-(2-Methoxypropan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 31	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7.00					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278569	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278569&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307243	378160163							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529952	CC(C)(C)c1onc(c1C(=O)N1CCc2c1cccc2\C=C\C(O)=O)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H21Cl3N2O4/c1-25(2,3)23-21(22(29-34-23)20-16(27)11-14(26)12-17(20)28)24(33)30-10-9-15-13(7-8-19(31)32)5-4-6-18(15)30/h4-8,11-12H,9-10H2,1-3H3,(H,31,32)/b8-7+	DHOYKWMMIZQDPN-BQYQJAHWSA-N	278570	 (2E)-3-(1-{[5-(tert-Butyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-2,3-dihydro-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 32	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 43					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278570	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278570&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307057	378160164							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529954	Cc1cn(C(=O)c2c(noc2C(C)(C)C)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H21Cl3N2O4/c1-13-12-31(18-7-5-6-14(20(13)18)8-9-19(32)33)25(34)22-23(30-35-24(22)26(2,3)4)21-16(28)10-15(27)11-17(21)29/h5-12H,1-4H3,(H,32,33)/b9-8+	KXPPLODPOGLEGB-CMDGGOBGSA-N	278571	 (2E)-3-(1-{[5-(tert-Butyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278571	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278571&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130306987	378160165							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529956	CC(C)(C)c1noc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H19Cl3N2O4/c1-25(2,3)23-21(22(34-29-23)20-16(27)11-14(26)12-17(20)28)24(33)30-10-9-15-13(7-8-19(31)32)5-4-6-18(15)30/h4-12H,1-3H3,(H,31,32)/b8-7+	TWGYWTMUIXWFOU-BQYQJAHWSA-N	278572	 (2E)-3-(1-{[3-(tert-Butyl)-5-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 34	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 53					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278572	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278572&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307244	378160166							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529958	CC(C)(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(F)cc(Cl)cc1Cl	InChI=1S/C25H19Cl2FN2O4/c1-25(2,3)23-21(22(29-34-23)20-16(27)11-14(26)12-17(20)28)24(33)30-10-9-15-13(7-8-19(31)32)5-4-6-18(15)30/h4-12H,1-3H3,(H,31,32)/b8-7+	XDRGKEBBTDBCJD-BQYQJAHWSA-N	278573	 (2E)-3-(1-{[5-(tert-Butyl)-3-(2,4-dichloro-6-fluorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 31					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278573	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278573&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307326	378160167							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529960	CC(C)(F)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C24H16Cl3FN2O4/c1-24(2,28)22-20(21(29-34-22)19-15(26)10-13(25)11-16(19)27)23(33)30-9-8-14-12(6-7-18(31)32)4-3-5-17(14)30/h3-11H,1-2H3,(H,31,32)/b7-6+	USRBFOUUSBSCQL-VOTSOKGWSA-N	278574	 (2E)-3-(1-{[5-(2-Fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 13					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278574	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278574&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307136	378160168							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529962	CC1(CC1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H17Cl3N2O4/c1-25(8-9-25)23-21(22(29-34-23)20-16(27)11-14(26)12-17(20)28)24(33)30-10-7-15-13(5-6-19(31)32)3-2-4-18(15)30/h2-7,10-12H,8-9H2,1H3,(H,31,32)/b6-5+	HCDHCLNCWWHWFR-AATRIKPKSA-N	278575	 (2E)-3-(1-{[5-(1-Methylcyclopropyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 37	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 13					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278575	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278575&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307247	378160169							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529964	Cc1cc(Cl)c(-c2noc(c2C(=O)n2ccc3c(\C=C\C(O)=O)cccc23)C(C)(C)C)c(Cl)c1	InChI=1S/C26H22Cl2N2O4/c1-14-12-17(27)21(18(28)13-14)23-22(24(34-29-23)26(2,3)4)25(33)30-11-10-16-15(8-9-20(31)32)6-5-7-19(16)30/h5-13H,1-4H3,(H,31,32)/b9-8+	POCJZMUEOXWJNG-CMDGGOBGSA-N	278576	 (2E)-3-(1-{[5-(tert-Butyl)-3-(2,6-dichloro-4-methylphenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 34					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278576	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278576&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307328	378160170							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529966	CC(C)(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Br	InChI=1S/C25H20BrClN2O4/c1-25(2,3)23-21(22(28-33-23)20-16(26)7-5-8-17(20)27)24(32)29-13-12-15-14(10-11-19(30)31)6-4-9-18(15)29/h4-13H,1-3H3,(H,30,31)/b11-10+	IMRHNXOLHZPEKS-ZHACJKMWSA-N	278577	 (2E)-3-(1-{[3-(2-Bromo-6-chlorophenyl)-5-(tert-butyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 39	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278577	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278577&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307249	378160171							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529968	CC(C)(C)c1onc(c1C(=O)n1cc(F)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H18Cl3FN2O4/c1-25(2,3)23-21(22(30-35-23)20-14(27)9-13(26)10-15(20)28)24(34)31-11-16(29)19-12(7-8-18(32)33)5-4-6-17(19)31/h4-11H,1-3H3,(H,32,33)/b8-7+	BOIGZCYRGKILGC-BQYQJAHWSA-N	278578	 (2E)-3-(1-{[5-(tert-Butyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-fluoro-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 21					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278578	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278578&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130306990	378160172							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529970	Cc1cc(Cl)cc(Cl)c1-c1noc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)C(C)(C)C	InChI=1S/C26H22Cl2N2O4/c1-14-12-16(27)13-18(28)21(14)23-22(24(34-29-23)26(2,3)4)25(33)30-11-10-17-15(8-9-20(31)32)6-5-7-19(17)30/h5-13H,1-4H3,(H,31,32)/b9-8+	AATFCJCQCIVGMT-CMDGGOBGSA-N	278579	 (2E)-3-(1-{[5-(tert-Butyl)-3-(2,4-dichloro-6-methylphenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid   ::US10040791, Example 41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 52					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278579	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278579&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307250	378160173							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529972	COCC(C)(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C26H21Cl3N2O5/c1-26(2,13-35-3)24-22(23(30-36-24)21-17(28)11-15(27)12-18(21)29)25(34)31-10-9-16-14(7-8-20(32)33)5-4-6-19(16)31/h4-12H,13H2,1-3H3,(H,32,33)/b8-7+	JRUHHIFYIWJNCM-BQYQJAHWSA-N	278580	 (2E)-3-(1-{[5-(1-Methoxy-2-methylpropan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 42	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 50					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278580	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278580&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307137	378160174							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529974	Cc1cn(C(=O)c2c(noc2C2(C)CC2)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H19Cl3N2O4/c1-13-12-31(18-5-3-4-14(20(13)18)6-7-19(32)33)25(34)22-23(30-35-24(22)26(2)8-9-26)21-16(28)10-15(27)11-17(21)29/h3-7,10-12H,8-9H2,1-2H3,(H,32,33)/b7-6+	VYFPNWUXLMTAEQ-VOTSOKGWSA-N	278581	 (2E)-3-(3-Methyl-1-{[5-(1-methylcyclopropyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 43	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278581	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278581&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307330	378160175							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529976	COC1(CC1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C25H17Cl3N2O5/c1-34-25(8-9-25)23-21(22(29-35-23)20-16(27)11-14(26)12-17(20)28)24(33)30-10-7-15-13(5-6-19(31)32)3-2-4-18(15)30/h2-7,10-12H,8-9H2,1H3,(H,31,32)/b6-5+	PXBRVLPBVPDPSB-AATRIKPKSA-N	278582	 (2E)-3-(1-{[5-(1-Methoxycyclopropyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 22					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278582	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278582&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307331	378160176							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529978	CC(C)(F)c1onc(c1C(=O)n1cc(F)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C24H15Cl3F2N2O4/c1-24(2,29)22-20(21(30-35-22)19-13(26)8-12(25)9-14(19)27)23(34)31-10-15(28)18-11(6-7-17(32)33)4-3-5-16(18)31/h3-10H,1-2H3,(H,32,33)/b7-6+	ZWPYXTYCFJBBGS-VOTSOKGWSA-N	278583	 (2E)-3-(3-Fluoro-1-{[5-(2-fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 13					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278583	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278583&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307138	378160177							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529980	CC(C)(F)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(F)cc(Cl)cc1Cl	InChI=1S/C24H16Cl2F2N2O4/c1-24(2,28)22-20(21(29-34-22)19-15(26)10-13(25)11-16(19)27)23(33)30-9-8-14-12(6-7-18(31)32)4-3-5-17(14)30/h3-11H,1-2H3,(H,31,32)/b7-6+	AOYWWPQSXIUJOE-VOTSOKGWSA-N	278584	 (2E)-3-(1-{[3-(2,4-Dichloro-6-fluorophenyl)-5-(2-fluoropropan-2-yl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid  ::US10040791, Example 46	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 28					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278584	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278584&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307141	378160178							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529982	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(F)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H18Cl2F2N2O4/c1-12-11-31(17-6-4-5-13(19(12)17)7-8-18(32)33)24(34)21-22(30-35-23(21)25(2,3)29)20-15(27)9-14(26)10-16(20)28/h4-11H,1-3H3,(H,32,33)/b8-7+	BVUMRBVNGXVXSA-BQYQJAHWSA-N	278585	(2E)-3-(1-{[3-(2,4-Dichloro-6- fluorophenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 47	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 13					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278585	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278585&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307214	378160179							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529984	CC(C)(F)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)ccc(F)c12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C24H15Cl3F2N2O4/c1-24(2,29)22-19(20(30-35-22)18-14(26)9-12(25)10-15(18)27)23(34)31-8-7-13-11(4-6-17(32)33)3-5-16(28)21(13)31/h3-10H,1-2H3,(H,32,33)/b6-4+	MWWIJOCRHKKPLJ-GQCTYLIASA-N	278586	(2E)-3-(1-{[5-(tert-Butyl)-3- (2,4,6-trichlorophenyl)-1,2- oxazole-4-carbonyl]-7- fluoroindol-4-yl]prop-2-enoic acid ::US10040791, Example 48	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278586	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278586&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132070937	378160180							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529986	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(F)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H18Cl2F2N2O4/c1-12-11-31(17-6-4-5-13(19(12)17)7-8-18(32)33)24(34)21-22(30-35-23(21)25(2,3)29)20-15(26)9-14(28)10-16(20)27/h4-11H,1-3H3,(H,32,33)/b8-7+	NYOISIQPEVFIMT-BQYQJAHWSA-N	278587	(2E)-3-(1-{[3-(2,6-Dichloro-4- fluorophenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 49	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 9.00					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278587	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278587&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307332	378160181							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529988	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(Cl)cc2Cl)c2c(F)ccc(\C=C\C(O)=O)c12	InChI=1S/C25H17Cl3F2N2O4/c1-11-10-32(22-16(29)6-4-12(18(11)22)5-7-17(33)34)24(35)20-21(31-36-23(20)25(2,3)30)19-14(27)8-13(26)9-15(19)28/h4-10H,1-3H3,(H,33,34)/b7-5+	XUYRICDZVZLNIE-FNORWQNLSA-N	278588	(2E)-3-(7-Fluoro-1-{[5-(2- fluoropropan-2-yl)-3-(2,4,6- trichlorophenyl)-1,2-oxazol-4- yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 50	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278588	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278588&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130306989	378160182							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529990	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H18Cl3FN2O4/c1-12-11-31(17-6-4-5-13(19(12)17)7-8-18(32)33)24(34)21-22(30-35-23(21)25(2,3)29)20-15(27)9-14(26)10-16(20)28/h4-11H,1-3H3,(H,32,33)/b8-7+	BOOMBLZEOHXPPX-BQYQJAHWSA-N	278589	(2E)-3-(1-{[5-(1,1- Difluoroethyl)-3-(2,4,6- trichlorophenyl)-1,2-oxazol-4- yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 51	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 15					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278589	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278589&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	7SU	7PJN	130306983	378160183							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529992	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(F)cccc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H19ClF2N2O4/c1-13-12-30(17-9-4-6-14(19(13)17)10-11-18(31)32)24(33)21-22(29-34-23(21)25(2,3)28)20-15(26)7-5-8-16(20)27/h4-12H,1-3H3,(H,31,32)/b11-10+	DSUHFQCULGTDCW-ZHACJKMWSA-N	278590	(2E)-3-(1-{[3-(2-Chloro-6- fluorophenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 52	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278590	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278590&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307062	378160184							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529994	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cccc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H19Cl2FN2O4/c1-13-12-30(17-9-4-6-14(19(13)17)10-11-18(31)32)24(33)21-22(29-34-23(21)25(2,3)28)20-15(26)7-5-8-16(20)27/h4-12H,1-3H3,(H,31,32)/b11-10+	OQWMYJNCGHXCIT-ZHACJKMWSA-N	278591	(2E)-3-(1-{[3-(2,6- Dichlorophenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 53	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278591	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278591&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307142	378160185							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529996	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(F)cc(Cl)cc2F)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H18ClF3N2O4/c1-12-11-31(17-6-4-5-13(19(12)17)7-8-18(32)33)24(34)21-22(30-35-23(21)25(2,3)29)20-15(27)9-14(26)10-16(20)28/h4-11H,1-3H3,(H,32,33)/b8-7+	CCWLDTLJVNIOJZ-BQYQJAHWSA-N	278592	(2E)-3-(1-{[3-(4-Chloro-2,6- difluorophenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 54	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278592	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278592&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307065	378160186							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
529998	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(C)cc(Cl)cc2C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C27H24ClFN2O4/c1-14-11-18(28)12-15(2)21(14)24-23(25(35-30-24)27(4,5)29)26(34)31-13-16(3)22-17(9-10-20(32)33)7-6-8-19(22)31/h6-13H,1-5H3,(H,32,33)/b10-9+	HJHDYWCLTZCBAL-MDZDMXLPSA-N	278593	(2E)-3-(1-{[3-(4-Chloro-2,6- dimethylphenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 55	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278593	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278593&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307149	378160187							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530000	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(C)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H21Cl2FN2O4/c1-13-10-16(27)21(17(28)11-13)23-22(24(35-30-23)26(3,4)29)25(34)31-12-14(2)20-15(8-9-19(32)33)6-5-7-18(20)31/h5-12H,1-4H3,(H,32,33)/b9-8+	YJTOZPRYQQAIKI-CMDGGOBGSA-N	278594	(2E)-3-(1-{[3-(2,6-Dichloro-4- methylphenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 56	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 15					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278594	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278594&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307252	378160188							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530002	COC1(CC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C26H19Cl3N2O5/c1-13-12-31(18-5-3-4-14(20(13)18)6-7-19(32)33)25(34)22-23(21-16(28)10-15(27)11-17(21)29)30-36-24(22)26(35-2)8-9-26/h3-7,10-12H,8-9H2,1-2H3,(H,32,33)/b7-6+	WYBFBZUIZFAUMH-VOTSOKGWSA-N	278595	(2E)-3-(1-{[5-(1- Methoxycyclopropyl)-3-(2,4,6- trichlorophenyl)-1,2-oxazol-4- yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 57	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10.00					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278595	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278595&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307066	378160189							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530004	COc1cc(Cl)cc(Cl)c1-c1noc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)C(C)(C)F	InChI=1S/C26H21Cl2FN2O5/c1-13-12-31(17-7-5-6-14(20(13)17)8-9-19(32)33)25(34)22-23(30-36-24(22)26(2,3)29)21-16(28)10-15(27)11-18(21)35-4/h5-12H,1-4H3,(H,32,33)/b9-8+	CKRCXEPSLCTCII-CMDGGOBGSA-N	278596	(2E)-3-(1-{[3-(2,4-Dichloro-6- methoxyphenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 27					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278596	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278596&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307067	378160190							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530006	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(C)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H21Cl2FN2O4/c1-13-10-16(27)11-17(28)21(13)23-22(24(35-30-23)26(3,4)29)25(34)31-12-14(2)20-15(8-9-19(32)33)6-5-7-18(20)31/h5-12H,1-4H3,(H,32,33)/b9-8+	UTTTVQJNSHYJMM-CMDGGOBGSA-N	278597	(2E)-3-(1-{[3-(2,4-Dichloro-6- methylphenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 59	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 15					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278597	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278597&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307333	378160191							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530008	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(C)cc(C)cc2C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C28H27FN2O4/c1-15-12-16(2)22(17(3)13-15)25-24(26(35-30-25)28(5,6)29)27(34)31-14-18(4)23-19(10-11-21(32)33)8-7-9-20(23)31/h7-14H,1-6H3,(H,32,33)/b11-10+	FCFMKLBKEDFTME-ZHACJKMWSA-N	278598	(2E)-3-(1-{[5-(2-Fluoropropan- 2-yl)-3-(2,4,6-trimethylphenyl)- 1,2-oxazol-4-yl]carbonyl}-3- methyl-1H-indol-4-yl)prop-2- enoic acid ::US10040791, Example 60	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278598	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278598&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130306993	378160192							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530010	Cc1cn(C(=O)c2c(noc2C(F)(F)F)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C23H12Cl3F3N2O4/c1-10-9-31(15-4-2-3-11(17(10)15)5-6-16(32)33)22(34)19-20(30-35-21(19)23(27,28)29)18-13(25)7-12(24)8-14(18)26/h2-9H,1H3,(H,32,33)/b6-5+	FPKKACLXGYDUPX-AATRIKPKSA-N	278599	(2E)-3-(3-Methyl-1-{[3-(2,4,6- trichlorophenyl)-5- (trifluoromethyl)-1,2-oxazol-4- yl]carbonyl}-1H-indol-4- yl)prop-2-enoic acid ::US10040791, Example 61	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 36					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278599	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278599&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307334	378160193							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530012	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2ccc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H19Cl2FN2O4/c1-13-12-30(18-6-4-5-14(20(13)18)7-10-19(31)32)24(33)21-22(29-34-23(21)25(2,3)28)16-9-8-15(26)11-17(16)27/h4-12H,1-3H3,(H,31,32)/b10-7+	MMJOWRUYBHASCG-JXMROGBWSA-N	278600	(2E)-3-(1-{[3-(2,4- Dichlorophenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 62	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278600	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278600&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307068	378160194							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530014	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2cc(F)c(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H18Cl2F2N2O4/c1-12-11-31(18-6-4-5-13(20(12)18)7-8-19(32)33)24(34)21-22(30-35-23(21)25(2,3)29)14-9-17(28)16(27)10-15(14)26/h4-11H,1-3H3,(H,32,33)/b8-7+	WBPDQOJZARDPEL-BQYQJAHWSA-N	278601	(2E)-3-(1-{[3-(2,4-Dichloro-5- fluorophenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 63	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 15					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278601	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278601&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307253	378160195							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530016	CC(=O)c1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H18Cl3FN2O5/c1-12(33)15-11-32(18-6-4-5-13(20(15)18)7-8-19(34)35)25(36)22-23(31-37-24(22)26(2,3)30)21-16(28)9-14(27)10-17(21)29/h4-11H,1-3H3,(H,34,35)/b8-7+	QGAVUUHKYZSBQO-BQYQJAHWSA-N	278602	(2E)-3-(3-Acetyl-1-{[5-(2- fluoropropan-2-yl)-3-(2,4,6- trichlorophenyl)-1,2-oxazol-4- yl]carbonyl}-1H-indol-4- yl)prop-2-enoic acid ::US10040791, Example 64	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 252					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278602	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278602&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130306992	378160196							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530018	CCc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H20Cl3FN2O4/c1-4-13-12-32(18-7-5-6-14(20(13)18)8-9-19(33)34)25(35)22-23(31-36-24(22)26(2,3)30)21-16(28)10-15(27)11-17(21)29/h5-12H,4H2,1-3H3,(H,33,34)/b9-8+	IQILTNDZZWHOEV-CMDGGOBGSA-N	278603	(2E)-3-(3-Ethyl-1-{[5-(2- fluoropropan-2-yl)-3-(2,4,6- trichlorophenyl)-1,2-oxazol-4- yl]carbonyl}-1H-indol-4- yl)prop-2-enoic acid ::US10040791, Example 65	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 22					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278603	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278603&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130306991	378160197							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530020	CC(C)(F)c1onc(c1C(=O)n1cc(Cl)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C24H15Cl4FN2O4/c1-24(2,29)22-20(21(30-35-22)19-13(26)8-12(25)9-14(19)27)23(34)31-10-15(28)18-11(6-7-17(32)33)4-3-5-16(18)31/h3-10H,1-2H3,(H,32,33)/b7-6+	GTUFCGZBEHYIGM-VOTSOKGWSA-N	278604	(2E)-3-(3-Chloro-1-{[5-(2- fluoropropan-2-yl)-3-(2,4,6- trichlorophenyl)-1,2-oxazol-4- yl]carbonyl}-1H-indol-4- yl)prop-2-enoic acid ::US10040791, Example 66	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278604	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278604&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307139	378160198							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530022	CC(C)(F)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3c(F)ccc1c23)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C26H17Cl3F2N2O4/c1-26(2,31)24-22(23(32-37-24)21-14(28)8-13(27)9-15(21)29)25(36)33-10-12-4-3-11(7-18(34)35)19-16(30)5-6-17(33)20(12)19/h5-10H,3-4H2,1-2H3,(H,34,35)/b11-7+	HOJSBNIOXHFHBI-YRNVUSSQSA-N	278605	(2E)-[6-Fluoro-1-{[5-(2- fluoropropan-2-yl)-3-(2,4,6- trichlorophenyl)-1,2-oxazol-4- yl]carbonyl}-3,4- dihydrobenzo[cd]indol-5(1H)- ylidene]ethanoic acid ::US10040791, Example 67	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278605	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278605&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307159	378160199							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530024	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(Br)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C25H18BrCl2FN2O4/c1-12-11-31(17-6-4-5-13(19(12)17)7-8-18(32)33)24(34)21-22(30-35-23(21)25(2,3)29)20-15(27)9-14(26)10-16(20)28/h4-11H,1-3H3,(H,32,33)/b8-7+	QKRPPLFDALWFIQ-BQYQJAHWSA-N	278606	(2E)-3-(1-{[3-(4-Bromo-2,6- dichlorophenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 68	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 15					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278606	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278606&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130306994	378160200							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530026	CC(C)(F)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1ccc(Cl)cc1Cl	InChI=1S/C26H19Cl2FN2O4/c1-26(2,29)24-22(23(30-35-24)17-9-8-15(27)11-18(17)28)25(34)31-12-14-7-6-13(10-20(32)33)16-4-3-5-19(31)21(14)16/h3-5,8-12H,6-7H2,1-2H3,(H,32,33)/b13-10+	PMMGFBOYSSKUGN-JLHYYAGUSA-N	278607	(2E)-[1-{[3-(2,4- Dichlorophenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3,4- dihydrobenzo[cd]indol-5(1H)- ylidene]ethanoic acid ::US10040791, Example 69	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278607	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278607&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307070	378160201							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530028	Cc1cn(C(=O)c2c(noc2C(C)(C)F)-c2c(Cl)cc(cc2Cl)C2CC2)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C28H23Cl2FN2O4/c1-14-13-33(20-6-4-5-16(22(14)20)9-10-21(34)35)27(36)24-25(32-37-26(24)28(2,3)31)23-18(29)11-17(12-19(23)30)15-7-8-15/h4-6,9-13,15H,7-8H2,1-3H3,(H,34,35)/b10-9+	ZYBSPNFPDQBLMM-MDZDMXLPSA-N	278608	(2E)-3-(1-{[3-(2,6-Dichloro-4- cyclopropylphenyl)-5-(2- fluoropropan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 70	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 16					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278608	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278608&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130306995	378160202							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530030	CC(C)(F)c1onc(c1C(=O)n1cc(C2CC2)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C27H20Cl3FN2O4/c1-27(2,31)25-23(24(32-37-25)22-17(29)10-15(28)11-18(22)30)26(36)33-12-16(13-6-7-13)21-14(8-9-20(34)35)4-3-5-19(21)33/h3-5,8-13H,6-7H2,1-2H3,(H,34,35)/b9-8+	QFGHNJIRWWIBFH-CMDGGOBGSA-N	278609	(2E)-3-(3-Cyclopropyl-1-{[5-(2-fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 71	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 81					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278609	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278609&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307167	378160203							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530032	CC(C)(C)c1onc(c1C(=O)n1cc(C(F)F)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C26H19Cl3F2N2O4/c1-26(2,3)23-21(22(32-37-23)20-15(28)9-13(27)10-16(20)29)25(36)33-11-14(24(30)31)19-12(7-8-18(34)35)5-4-6-17(19)33/h4-11,24H,1-3H3,(H,34,35)/b8-7+	JUAQLUCSKVIFPL-BQYQJAHWSA-N	278610	(2E)-3-(1-{[5-(tert-Butyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-(difluoromethyl)-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 72	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 25					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278610	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278610&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307000	378160204							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530034	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(noc1-c1ccc(C=C)nc1)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C28H16Cl3N3O4/c1-2-18-8-6-16(14-32-18)27-25(26(33-38-27)24-20(30)12-17(29)13-21(24)31)28(37)34-11-10-19-15(7-9-23(35)36)4-3-5-22(19)34/h2-14H,1H2,(H,35,36)/b9-7+	FXAOGOGERGMUHQ-VQHVLOKHSA-N	278611	(2E)-3-(1-{[5-(6-Ethenylpyridin-3-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 73	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 43					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278611	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278611&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307147	378160205							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530036	COC1(CCC1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C26H19Cl3N2O5/c1-35-26(9-3-10-26)24-22(23(30-36-24)21-17(28)12-15(27)13-18(21)29)25(34)31-11-8-16-14(6-7-20(32)33)4-2-5-19(16)31/h2,4-8,11-13H,3,9-10H2,1H3,(H,32,33)/b7-6+	ASVPWKNLTARYMM-VOTSOKGWSA-N	278612	(2E)-3-(1-{[5-(1-Methoxycyclobutyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 74	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278612	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278612&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307337	378160206							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530038	CC1(COC1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C25H18Cl2N2O5/c1-25(12-33-13-25)23-21(22(28-34-23)20-16(26)5-3-6-17(20)27)24(32)29-11-10-15-14(8-9-19(30)31)4-2-7-18(15)29/h2-11H,12-13H2,1H3,(H,30,31)/b9-8+	JNJIAVNFRMJGQU-CMDGGOBGSA-N	278613	(2E)-3-(1-{[3-(2,6- Dichlorophenyl)-5-(3- methyloxetan-3-yl)-1,2-oxazol- 4-yl]carbonyl}-1H-indol-4- yl)prop-2-enoic acid ::US10040791, Example 75	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278613	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278613&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307005	378160207							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530040	COC1(COC1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C25H18Cl2N2O6/c1-33-25(12-34-13-25)23-21(22(28-35-23)20-16(26)5-3-6-17(20)27)24(32)29-11-10-15-14(8-9-19(30)31)4-2-7-18(15)29/h2-11H,12-13H2,1H3,(H,30,31)/b9-8+	ICGQVDDAIBQZER-CMDGGOBGSA-N	278614	(2E)-3-(1-{[3-(2,6- Dichlorophenyl)-5-(3- methoxyoxetan-3-yl)-1,2- oxazol-4-yl]carbonyl}-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 76	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 6.00					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278614	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278614&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307144	378160208							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530042	CC1(CCO1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C25H18Cl2N2O5/c1-25(11-13-33-25)23-21(22(28-34-23)20-16(26)5-3-6-17(20)27)24(32)29-12-10-15-14(8-9-19(30)31)4-2-7-18(15)29/h2-10,12H,11,13H2,1H3,(H,30,31)/b9-8+	ICORGZBJRVKPJH-CMDGGOBGSA-N	278615	(2E)-3-(1-{[3-(2,6- Dichlorophenyl)-5-(2- methyloxetan-2-yl)-1,2-oxazol- 4-yl]carbonyl}-1H-indol-4- yl)prop-2-enoic acid ::US10040791, Example 77	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 8.00					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278615	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278615&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307170	378160209							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530044	Cc1cn(C(=O)c2c(noc2C2(C)COC2)-c2ccc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H20Cl2N2O5/c1-14-11-30(19-5-3-4-15(21(14)19)6-9-20(31)32)25(33)22-23(17-8-7-16(27)10-18(17)28)29-35-24(22)26(2)12-34-13-26/h3-11H,12-13H2,1-2H3,(H,31,32)/b9-6+	QKDGUBMFMNBEAM-RMKNXTFCSA-N	278616	(2E)-3-(1-{[3-(2,4- Dichlorophenyl)-5-(3- methyloxetan-3-yl)-1,2-oxazol- 4-yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 78	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 33					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278616	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278616&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130306999	378160210							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530046	COC1(CCC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C27H21Cl3N2O5/c1-14-13-32(19-6-3-5-15(21(14)19)7-8-20(33)34)26(35)23-24(22-17(29)11-16(28)12-18(22)30)31-37-25(23)27(36-2)9-4-10-27/h3,5-8,11-13H,4,9-10H2,1-2H3,(H,33,34)/b8-7+	HOVOVARKDAICLH-BQYQJAHWSA-N	278617	(2E)-3-(1-{[5-(1- Methoxycyclobutyl)-3-(2,4,6- trichlorophenyl)-1,2-oxazol-4- yl]carbonyl}-3-methyl-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 79	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 21					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278617	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278617&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307003	378160211							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530048	COCC1(CCC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C28H23Cl3N2O5/c1-15-13-33(20-6-3-5-16(22(15)20)7-8-21(34)35)27(36)24-25(23-18(30)11-17(29)12-19(23)31)32-38-26(24)28(14-37-2)9-4-10-28/h3,5-8,11-13H,4,9-10,14H2,1-2H3,(H,34,35)/b8-7+	RQBVWIAGIKITQA-BQYQJAHWSA-N	278618	(2E)-3-(1-{[5-[1- (Methoxymethyl)cyclobutyl]-3- (2,4,6-trichlorophenyl)-1,2- oxazol-4-yl]carbonyl}-3- methyl-1H-indol-4-yl)prop-2- enoic acid ::US10040791, Example 80	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 49					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278618	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278618&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307336	378160212							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530050	CN(C)C1(CCC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C28H24Cl3N3O4/c1-15-14-34(20-7-4-6-16(22(15)20)8-9-21(35)36)27(37)24-25(23-18(30)12-17(29)13-19(23)31)32-38-26(24)28(33(2)3)10-5-11-28/h4,6-9,12-14H,5,10-11H2,1-3H3,(H,35,36)/b9-8+	HWUIGZVLXYUEMK-CMDGGOBGSA-N	278619	(2E)-3-(1-{[5-[1-(Dimethylamino)cyclobutyl]-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 26					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278619	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278619&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307173	378160213							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530052	CN(C)C1(CC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C27H22Cl3N3O4/c1-14-13-33(19-6-4-5-15(21(14)19)7-8-20(34)35)26(36)23-24(22-17(29)11-16(28)12-18(22)30)31-37-25(23)27(9-10-27)32(2)3/h4-8,11-13H,9-10H2,1-3H3,(H,34,35)/b8-7+	ADKCWUPCLIWNNO-BQYQJAHWSA-N	278620	(2E)-3-(1-{[5-[1- (Dimethylamino)cyclopropyl]- 3-(2,4,6-trichlorophenyl)-1,2- oxazol-4-yl]carbonyl}-3- methyl-1H-indol-4-yl)prop-2- enoic acid ::US10040791, Example 82	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 13					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278620	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278620&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307148	378160214							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530054	CNC1(CCC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C27H22Cl3N3O4/c1-14-13-33(19-6-3-5-15(21(14)19)7-8-20(34)35)26(36)23-24(22-17(29)11-16(28)12-18(22)30)32-37-25(23)27(31-2)9-4-10-27/h3,5-8,11-13,31H,4,9-10H2,1-2H3,(H,34,35)/b8-7+	UVTWTYURHDRISP-BQYQJAHWSA-N	278621	(2E)-3-(3-Methyl-1-{[5-[1-(methylamino)cyclobutyl]-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278621	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278621&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307008	378160215							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530056	CNC(C)(C)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C26H22Cl3N3O4/c1-13-12-32(18-7-5-6-14(20(13)18)8-9-19(33)34)25(35)22-23(31-36-24(22)26(2,3)30-4)21-16(28)10-15(27)11-17(21)29/h5-12,30H,1-4H3,(H,33,34)/b9-8+	JGTKFHUTIOMNMG-CMDGGOBGSA-N	278622	(2E)-3-[3-Methyl-1-({5-[2- (methylamino)propan-2-yl]-3- (2,4,6-trichlorophenyl)-1,2- oxazol-4-yl]carbonyl}-1H- indol-4-yl)prop-2-enoic acid ::US10040791, Example 84	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 15					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278622	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278622&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307150	378160216							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530058	CNC(C)(C)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C27H22Cl3N3O4/c1-27(2,31-3)25-23(24(32-37-25)22-17(29)10-15(28)11-18(22)30)26(36)33-12-14-8-7-13(9-20(34)35)16-5-4-6-19(33)21(14)16/h4-6,9-12,31H,7-8H2,1-3H3,(H,34,35)/b13-9+	DNMLSJMVECKSQZ-UKTHLTGXSA-N	278623	(2E)-[1-({5-[2- (Methylamino)propan-2-yl]-3- (2,4,6-trichlorophenyl)-1,2- oxazol-4-yl}carbonyl)-3,4- dihydrobenzo[cd]indol-5(1H)- ylidene]ethanoic acid ::US10040791, Example 85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278623	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278623&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307153	378160217							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530060	CNC1(CC1)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C27H20Cl3N3O4/c1-31-27(7-8-27)25-23(24(32-37-25)22-17(29)10-15(28)11-18(22)30)26(36)33-12-14-6-5-13(9-20(34)35)16-3-2-4-19(33)21(14)16/h2-4,9-12,31H,5-8H2,1H3,(H,34,35)/b13-9+	VOQZIABIIAPGMT-UKTHLTGXSA-N	278624	(2E)-[1-({5-[1- (Methylamino)cyclopropyl]-3- (2,4,6-trichlorophenyl)-1,2- oxazol-4-yl}carbonyl)-3,4- dihydrobenzo[cd]indol-5(1H)- ylidene]ethanoic acid ::US10040791, Example 86	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 8.00					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278624	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278624&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307011	378160218							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530062	CN(C(=O)C=C)C1(CCC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C30H24Cl3N3O5/c1-4-22(37)35(3)30(11-6-12-30)28-26(27(34-41-28)25-19(32)13-18(31)14-20(25)33)29(40)36-15-16(2)24-17(9-10-23(38)39)7-5-8-21(24)36/h4-5,7-10,13-15H,1,6,11-12H2,2-3H3,(H,38,39)/b10-9+	YXBCQUICNXIUIG-MDZDMXLPSA-N	278625	(2E)-3-(1-{[5-{1-[Acryloyl(methyl)amino]cyclobutyl}-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 34					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278625	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278625&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307072	378160219							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530064	CN(C)CC1(CCC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C29H26Cl3N3O4/c1-16-14-35(21-7-4-6-17(23(16)21)8-9-22(36)37)28(38)25-26(24-19(31)12-18(30)13-20(24)32)33-39-27(25)29(10-5-11-29)15-34(2)3/h4,6-9,12-14H,5,10-11,15H2,1-3H3,(H,36,37)/b9-8+	ZCYNRQVUCJXHSY-CMDGGOBGSA-N	278626	(2E)-3-(1-{[5-{1-[(Dimethylamino)methyl]cyclobutyl}-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 88	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 23					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278626	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278626&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307158	378160220							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530066	CN(C)C(=O)C1(CCC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C29H24Cl3N3O5/c1-15-14-35(20-7-4-6-16(22(15)20)8-9-21(36)37)27(38)24-25(23-18(31)12-17(30)13-19(23)32)33-40-26(24)29(10-5-11-29)28(39)34(2)3/h4,6-9,12-14H,5,10-11H2,1-3H3,(H,36,37)/b9-8+	LWWAJJNQDWRXSD-CMDGGOBGSA-N	278627	(2E)-3-(1-{[5-[1-(Dimethylcarbamoyl)cyclobutyl]-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 50					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278627	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278627&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307340	378160221							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530068	Cc1cn(C(=O)c2c(noc2C2(N)CCC2)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H20Cl3N3O4/c1-13-12-32(18-5-2-4-14(20(13)18)6-7-19(33)34)25(35)22-23(21-16(28)10-15(27)11-17(21)29)31-36-24(22)26(30)8-3-9-26/h2,4-7,10-12H,3,8-9,30H2,1H3,(H,33,34)/b7-6+	MDACIPHPUNNIDF-VOTSOKGWSA-N	278628	(2E)-3-(1-{[5-(1-Aminocyclobutyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 90	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7.00					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278628	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278628&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307162	378160222							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530070	CN(C)C(C)(C)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C27H24Cl3N3O4/c1-14-13-33(19-8-6-7-15(21(14)19)9-10-20(34)35)26(36)23-24(22-17(29)11-16(28)12-18(22)30)31-37-25(23)27(2,3)32(4)5/h6-13H,1-5H3,(H,34,35)/b10-9+	XKYNZOJQGKVERP-MDZDMXLPSA-N	278629	(2E)-3-[1-({5-[2-(Dimethylamino)propan-2-yl]-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-3-methyl-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 21					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278629	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278629&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307179	378160223							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530072	CN(C)C1(CC1)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C28H22Cl3N3O4/c1-33(2)28(8-9-28)26-24(25(32-38-26)23-18(30)11-16(29)12-19(23)31)27(37)34-13-15-7-6-14(10-21(35)36)17-4-3-5-20(34)22(15)17/h3-5,10-13H,6-9H2,1-2H3,(H,35,36)/b14-10+	PLRVVEGDTXSPNU-GXDHUFHOSA-N	278630	US10040791, Example 92	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10.00					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278630	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278630&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307017	378160224							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530074	Cc1cn(C(=O)c2c(noc2C2(CCC2)C#N)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C27H18Cl3N3O4/c1-14-12-33(19-5-2-4-15(21(14)19)6-7-20(34)35)26(36)23-24(22-17(29)10-16(28)11-18(22)30)32-37-25(23)27(13-31)8-3-9-27/h2,4-7,10-12H,3,8-9H2,1H3,(H,34,35)/b7-6+	LPZYXALZTFWCGH-VOTSOKGWSA-N	278631	(2E)-3-(1-{[5-(1-Cyanocyclobutyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3-methyl-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 93	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278631	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278631&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307258	378160225							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530076	OC(=O)\C=C1/CCc2cn(C(=O)c3c(onc3-c3c(Cl)cc(Cl)cc3Cl)C3CCN(CC3)C(=O)C=C)c3cccc1c23	InChI=1S/C31H24Cl3N3O5/c1-2-24(38)36-10-8-16(9-11-36)30-28(29(35-42-30)27-21(33)13-19(32)14-22(27)34)31(41)37-15-18-7-6-17(12-25(39)40)20-4-3-5-23(37)26(18)20/h2-5,12-16H,1,6-11H2,(H,39,40)/b17-12+	CMZJOEOPYWOXKF-SFQUDFHCSA-N	278632	(2E)-[1-{[5-(1-Acryloylpiperidin-4-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzo[cd]indol-5(1H)-ylidene]ethanoic acid::US10040791, Example 94	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 24					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278632	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278632&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307186	378160226							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530078	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)C1CN(C1)C(=O)C=C	InChI=1S/C27H18Cl3N3O5/c1-2-21(34)32-12-15(13-32)26-24(25(31-38-26)23-18(29)10-16(28)11-19(23)30)27(37)33-9-8-17-14(6-7-22(35)36)4-3-5-20(17)33/h2-11,15H,1,12-13H2,(H,35,36)/b7-6+	LSNVNZWGLMRMOA-VOTSOKGWSA-N	278633	US10040791, Example 95	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 6.00					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278633	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278633&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307165	378160227							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530080	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)C1CCCN(C1)C(=O)C=C	InChI=1S/C29H22Cl3N3O5/c1-2-23(36)34-11-4-6-17(15-34)28-26(27(33-40-28)25-20(31)13-18(30)14-21(25)32)29(39)35-12-10-19-16(8-9-24(37)38)5-3-7-22(19)35/h2-3,5,7-10,12-14,17H,1,4,6,11,15H2,(H,37,38)/b9-8+	IATXSYSSKVHZIR-CMDGGOBGSA-N	278634	US10040791, Example 96	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 149					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278634	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278634&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307344	378160228							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530082	COC1(CN(C1)C(=O)C=C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C28H20Cl3N3O6/c1-3-21(35)33-13-28(14-33,39-2)26-24(25(32-40-26)23-18(30)11-16(29)12-19(23)31)27(38)34-10-9-17-15(7-8-22(36)37)5-4-6-20(17)34/h3-12H,1,13-14H2,2H3,(H,36,37)/b8-7+	ZEABNMJGQXPLEO-BQYQJAHWSA-N	278635	US10040791, Example 97	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 19					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278635	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278635&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307166	378160229							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530084	CC1(CN(C1)C(=O)C=C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C28H20Cl3N3O5/c1-3-21(35)33-13-28(2,14-33)26-24(25(32-39-26)23-18(30)11-16(29)12-19(23)31)27(38)34-10-9-17-15(7-8-22(36)37)5-4-6-20(17)34/h3-12H,1,13-14H2,2H3,(H,36,37)/b8-7+	KVSHZPGHVSROLM-BQYQJAHWSA-N	278636	US10040791, Example 98	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 19					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278636	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278636&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307190	378160230							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530086	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)C1CCN(CC1)C(=O)C=C	InChI=1S/C29H22Cl3N3O5/c1-2-23(36)34-11-8-17(9-12-34)28-26(27(33-40-28)25-20(31)14-18(30)15-21(25)32)29(39)35-13-10-19-16(6-7-24(37)38)4-3-5-22(19)35/h2-7,10,13-15,17H,1,8-9,11-12H2,(H,37,38)/b7-6+	QNXKXQBXQDNUQO-VOTSOKGWSA-N	278637	US10040791, Example 99	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 142					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278637	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278637&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307174	378160231							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530088	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)C1CCN(CC1)C(=O)C#C	InChI=1S/C29H20Cl3N3O5/c1-2-23(36)34-11-8-17(9-12-34)28-26(27(33-40-28)25-20(31)14-18(30)15-21(25)32)29(39)35-13-10-19-16(6-7-24(37)38)4-3-5-22(19)35/h1,3-7,10,13-15,17H,8-9,11-12H2,(H,37,38)/b7-6+	CHNAINSHCUVKLS-VOTSOKGWSA-N	278638	US10040791, Example 100	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 37					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278638	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278638&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307175	378160232							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530090	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)C1CN(C1)C(=O)C#C	InChI=1S/C27H16Cl3N3O5/c1-2-21(34)32-12-15(13-32)26-24(25(31-38-26)23-18(29)10-16(28)11-19(23)30)27(37)33-9-8-17-14(6-7-22(35)36)4-3-5-20(17)33/h1,3-11,15H,12-13H2,(H,35,36)/b7-6+	VIMRJHVJAVWFKT-VOTSOKGWSA-N	278639	US10040791, Example 101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 16					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278639	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278639&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307346	378160233							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530092	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cccc1Cl)C1CCN(CC1)C(=O)C=C	InChI=1S/C29H23Cl2N3O5/c1-2-23(35)33-14-11-18(12-15-33)28-26(27(32-39-28)25-20(30)6-4-7-21(25)31)29(38)34-16-13-19-17(9-10-24(36)37)5-3-8-22(19)34/h2-10,13,16,18H,1,11-12,14-15H2,(H,36,37)/b10-9+	WRWLWJJKRVPXGR-MDZDMXLPSA-N	278640	US10040791, Example 102	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 53					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278640	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278640&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307262	378160234							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530094	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)C1CCN(CC1)S(=O)(=O)C=C	InChI=1S/C28H22Cl3N3O6S/c1-2-41(38,39)33-11-8-17(9-12-33)27-25(26(32-40-27)24-20(30)14-18(29)15-21(24)31)28(37)34-13-10-19-16(6-7-23(35)36)4-3-5-22(19)34/h2-7,10,13-15,17H,1,8-9,11-12H2,(H,35,36)/b7-6+	HSWZYJKXKLAJHP-VOTSOKGWSA-N	278641	US10040791, Example 103	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 25					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278641	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278641&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307176	378160235							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530096	Cc1cn(C(=O)c2c(onc2-c2c(Cl)cc(Cl)cc2Cl)C2CCN(CC2)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C30H24Cl3N3O5/c1-3-23(37)35-11-9-18(10-12-35)29-27(28(34-41-29)26-20(32)13-19(31)14-21(26)33)30(40)36-15-16(2)25-17(7-8-24(38)39)5-4-6-22(25)36/h3-8,13-15,18H,1,9-12H2,2H3,(H,38,39)/b8-7+	OQCSPKPCFMSGAE-BQYQJAHWSA-N	278642	US10040791, Example 104	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 32					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278642	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278642&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307073	378160236							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530098	OC(=O)C1CC1c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)C1CCN(CC1)C(=O)C=C	InChI=1S/C30H24Cl3N3O5/c1-2-24(37)35-9-6-15(7-10-35)28-26(27(34-41-28)25-21(32)12-16(31)13-22(25)33)29(38)36-11-8-18-17(4-3-5-23(18)36)19-14-20(19)30(39)40/h2-5,8,11-13,15,19-20H,1,6-7,9-10,14H2,(H,39,40)	GCHDNDCHWIOMRR-UHFFFAOYSA-N	278643	US10040791, Example 105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 519					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278643	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278643&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307019	378160237							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530100	Cc1cn(C(=O)c2c(onc2-c2ccc(Cl)cc2Cl)C2CCN(CC2)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C30H25Cl2N3O5/c1-3-24(36)34-13-11-19(12-14-34)29-27(28(33-40-29)21-9-8-20(31)15-22(21)32)30(39)35-16-17(2)26-18(7-10-25(37)38)5-4-6-23(26)35/h3-10,15-16,19H,1,11-14H2,2H3,(H,37,38)/b10-7+	RDZBITAYWJWVBX-JXMROGBWSA-N	278644	US10040791, Example 106	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 64					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278644	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278644&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307345	378160238							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530102	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(F)cc(Cl)cc1Cl)C1CCN(CC1)C(=O)C=C	InChI=1S/C29H22Cl2FN3O5/c1-2-23(36)34-11-8-17(9-12-34)28-26(27(33-40-28)25-20(31)14-18(30)15-21(25)32)29(39)35-13-10-19-16(6-7-24(37)38)4-3-5-22(19)35/h2-7,10,13-15,17H,1,8-9,11-12H2,(H,37,38)/b7-6+	CYIIMTPWLIOMSY-VOTSOKGWSA-N	278645	US10040791, Example 107	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 66					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278645	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278645&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307075	378160239							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530104	Cc1cn(C(=O)c2c(onc2-c2c(Cl)cccc2Cl)C2CCN(CC2)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C30H25Cl2N3O5/c1-3-23(36)34-14-12-19(13-15-34)29-27(28(33-40-29)26-20(31)7-5-8-21(26)32)30(39)35-16-17(2)25-18(10-11-24(37)38)6-4-9-22(25)35/h3-11,16,19H,1,12-15H2,2H3,(H,37,38)/b11-10+	KRAUYSVFLVTJMW-ZHACJKMWSA-N	278646	US10040791, Example 108	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 35					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278646	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278646&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307189	378160240							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530106	Cc1cc(C)c(-c2noc(C3CCN(CC3)C(=O)C=C)c2C(=O)n2ccc3c(\C=C\C(O)=O)cccc23)c(C)c1	InChI=1S/C32H31N3O5/c1-5-26(36)34-14-11-23(12-15-34)31-29(30(33-40-31)28-20(3)17-19(2)18-21(28)4)32(39)35-16-13-24-22(9-10-27(37)38)7-6-8-25(24)35/h5-10,13,16-18,23H,1,11-12,14-15H2,2-4H3,(H,37,38)/b10-9+	IFKSWVJENTVUAV-MDZDMXLPSA-N	278647	US10040791, Example 109	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 127					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278647	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278647&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307026	378160241							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530108	Cc1cc(Cl)cc(C)c1-c1noc(C2CCN(CC2)C(=O)C=C)c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12	InChI=1S/C31H28ClN3O5/c1-4-25(36)34-13-10-21(11-14-34)30-28(29(33-40-30)27-18(2)16-22(32)17-19(27)3)31(39)35-15-12-23-20(8-9-26(37)38)6-5-7-24(23)35/h4-9,12,15-17,21H,1,10-11,13-14H2,2-3H3,(H,37,38)/b9-8+	NKXDOIDVZXEBPS-CMDGGOBGSA-N	278648	US10040791, Example 110	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 158					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278648	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278648&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307177	378160242							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530110	CC1(CCN(CC1)C(=O)C=C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C30H24Cl3N3O5/c1-3-23(37)35-13-10-30(2,11-14-35)28-26(27(34-41-28)25-20(32)15-18(31)16-21(25)33)29(40)36-12-9-19-17(7-8-24(38)39)5-4-6-22(19)36/h3-9,12,15-16H,1,10-11,13-14H2,2H3,(H,38,39)/b8-7+	QHIWXOFVPUWFCD-BQYQJAHWSA-N	278649	US10040791, Example 111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 69					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278649	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278649&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307027	378160243							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530112	Cc1cn(C(=O)c2c(onc2-c2c(Cl)cc(F)cc2Cl)C2CCN(CC2)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C30H24Cl2FN3O5/c1-3-23(37)35-11-9-18(10-12-35)29-27(28(34-41-29)26-20(31)13-19(33)14-21(26)32)30(40)36-15-16(2)25-17(7-8-24(38)39)5-4-6-22(25)36/h3-8,13-15,18H,1,9-12H2,2H3,(H,38,39)/b8-7+	OLSZYSVLPKIWFU-BQYQJAHWSA-N	278650	US10040791, Example 112	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 31					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278650	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278650&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307076	378160244							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530114	Cc1cn(C(=O)c2c(noc2C2(C)CCN(CC2)C(=O)C=C)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C31H26Cl3N3O5/c1-4-23(38)36-12-10-31(3,11-13-36)29-27(28(35-42-29)26-20(33)14-19(32)15-21(26)34)30(41)37-16-17(2)25-18(8-9-24(39)40)6-5-7-22(25)37/h4-9,14-16H,1,10-13H2,2-3H3,(H,39,40)/b9-8+	NRZOBPKLVYBMMQ-CMDGGOBGSA-N	278651	US10040791, Example 113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 27					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278651	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278651&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307348	378160245							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530116	Cc1cn(C(=O)c2c(onc2-c2c(C)cc(C)cc2C)C2CCN(CC2)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C33H33N3O5/c1-6-26(37)35-14-12-24(13-15-35)32-30(31(34-41-32)28-20(3)16-19(2)17-21(28)4)33(40)36-18-22(5)29-23(10-11-27(38)39)8-7-9-25(29)36/h6-11,16-18,24H,1,12-15H2,2-5H3,(H,38,39)/b11-10+	ASRIWAMVNPKEQY-ZHACJKMWSA-N	278652	US10040791, Example 114	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 21					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278652	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278652&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307263	378160246							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530118	Cc1cn(C(=O)c2c(onc2-c2c(Cl)cc(Cl)cc2Cl)C2CCN(CC2)C(=O)C=C)c2cccc(CCC(O)=O)c12	InChI=1S/C30H26Cl3N3O5/c1-3-23(37)35-11-9-18(10-12-35)29-27(28(34-41-29)26-20(32)13-19(31)14-21(26)33)30(40)36-15-16(2)25-17(7-8-24(38)39)5-4-6-22(25)36/h3-6,13-15,18H,1,7-12H2,2H3,(H,38,39)	APFWWCWTBSANOT-UHFFFAOYSA-N	278653	US10040791, Example 115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 147					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278653	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278653&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307350	378160247							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530120	C\C(=C/c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)C1CCN(CC1)C(=O)C=C)C(O)=O	InChI=1S/C30H24Cl3N3O5/c1-3-24(37)35-10-7-17(8-11-35)28-26(27(34-41-28)25-21(32)14-19(31)15-22(25)33)29(38)36-12-9-20-18(5-4-6-23(20)36)13-16(2)30(39)40/h3-6,9,12-15,17H,1,7-8,10-11H2,2H3,(H,39,40)/b16-13+	DVCSJUAIOWDAIW-DTQAZKPQSA-N	278654	US10040791, Example 116	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 440					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278654	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278654&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307191	378160248							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530122	COC1(CCN(CC1)C(=O)C=C)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C31H26Cl3N3O6/c1-4-23(38)36-12-10-31(42-3,11-13-36)29-27(28(35-43-29)26-20(33)14-19(32)15-21(26)34)30(41)37-16-17(2)25-18(8-9-24(39)40)6-5-7-22(25)37/h4-9,14-16H,1,10-13H2,2-3H3,(H,39,40)/b9-8+	IQVLOSQGBGAFAU-CMDGGOBGSA-N	278655	US10040791, Example 117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 23					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278655	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278655&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307031	378160249							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530124	OC(=O)\C=C\c1cccc2n(ncc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)C1CCN(CC1)C(=O)C=C	InChI=1S/C28H21Cl3N4O5/c1-2-22(36)34-10-8-16(9-11-34)27-25(26(33-40-27)24-19(30)12-17(29)13-20(24)31)28(39)35-21-5-3-4-15(6-7-23(37)38)18(21)14-32-35/h2-7,12-14,16H,1,8-11H2,(H,37,38)/b7-6+	SWURKQYRUCMQLT-VOTSOKGWSA-N	278656	US10040791, Example 118	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 509					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278656	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278656&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307184	378160250							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530126	C\C=C\C(=O)N1CCC(CC1)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C31H26Cl3N3O5/c1-3-5-24(38)36-12-10-19(11-13-36)30-28(29(35-42-30)27-21(33)14-20(32)15-22(27)34)31(41)37-16-17(2)26-18(8-9-25(39)40)6-4-7-23(26)37/h3-9,14-16,19H,10-13H2,1-2H3,(H,39,40)/b5-3+,9-8+	JQOLVOZQJFCFCB-YEQUJYSKSA-N	278657	US10040791, Example 119	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 73					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278657	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278657&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307351	378160251							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530128	COCC1(CCN(CC1)C(=O)C=C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C31H26Cl3N3O6/c1-3-24(38)36-13-10-31(11-14-36,17-42-2)29-27(28(35-43-29)26-21(33)15-19(32)16-22(26)34)30(41)37-12-9-20-18(7-8-25(39)40)5-4-6-23(20)37/h3-9,12,15-16H,1,10-11,13-14,17H2,2H3,(H,39,40)/b8-7+	PRKOTSIWJLRFJM-BQYQJAHWSA-N	278658	US10040791, Example 120	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 119					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278658	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278658&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307353	378160252							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530130	Cc1cn(C(=O)c2c(onc2-c2cc(F)c(Cl)cc2Cl)C2CCN(CC2)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C30H24Cl2FN3O5/c1-3-24(37)35-11-9-18(10-12-35)29-27(28(34-41-29)19-13-22(33)21(32)14-20(19)31)30(40)36-15-16(2)26-17(7-8-25(38)39)5-4-6-23(26)36/h3-8,13-15,18H,1,9-12H2,2H3,(H,38,39)/b8-7+	OCEWIPPXOQOQQP-BQYQJAHWSA-N	278659	US10040791, Example 121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 43					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278659	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278659&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307077	378160253							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530132	Cc1cn(C(=O)c2c(onc2-c2c(C)cc(Cl)cc2C)C2CCN(CC2)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C32H30ClN3O5/c1-5-25(37)35-13-11-22(12-14-35)31-29(30(34-41-31)27-18(2)15-23(33)16-19(27)3)32(40)36-17-20(4)28-21(9-10-26(38)39)7-6-8-24(28)36/h5-10,15-17,22H,1,11-14H2,2-4H3,(H,38,39)/b10-9+	MVRYLDWWLXDTFY-MDZDMXLPSA-N	278660	US10040791, Example 122	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 32					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278660	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278660&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307032	378160254							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530134	Cc1cn(C(=O)c2c(noc2C2(O)CCN(CC2)C(=O)C=C)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C30H24Cl3N3O6/c1-3-22(37)35-11-9-30(41,10-12-35)28-26(27(34-42-28)25-19(32)13-18(31)14-20(25)33)29(40)36-15-16(2)24-17(7-8-23(38)39)5-4-6-21(24)36/h3-8,13-15,41H,1,9-12H2,2H3,(H,38,39)/b8-7+	WCYDRAWVHFFUSE-BQYQJAHWSA-N	278661	US10040791, Example 123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 28					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278661	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278661&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307200	378160255							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530136	Cc1cn(C(=O)c2c(onc2-c2c(Cl)cc(Cl)cc2Cl)C2C3CN(CC23)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C30H22Cl3N3O5/c1-3-22(37)35-12-17-18(13-35)25(17)29-27(28(34-41-29)26-19(32)9-16(31)10-20(26)33)30(40)36-11-14(2)24-15(7-8-23(38)39)5-4-6-21(24)36/h3-11,17-18,25H,1,12-13H2,2H3,(H,38,39)/b8-7+	VDYUEXGDLAHKLA-BQYQJAHWSA-N	278662	US10040791, Example 124	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 61					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278662	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278662&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307078	378160256							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530138	OC(=O)CC1CCc2cn(C(=O)c3c(onc3-c3c(Cl)cc(Cl)cc3Cl)C3CCN(CC3)C(=O)C=C)c3cccc1c23	InChI=1S/C31H26Cl3N3O5/c1-2-24(38)36-10-8-16(9-11-36)30-28(29(35-42-30)27-21(33)13-19(32)14-22(27)34)31(41)37-15-18-7-6-17(12-25(39)40)20-4-3-5-23(37)26(18)20/h2-5,13-17H,1,6-12H2,(H,39,40)	MCBXERFWRRATGD-UHFFFAOYSA-N	278663	US10040791, Example 125	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 355					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278663	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278663&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307264	378160257							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530140	CN(C)C1(CCN(CC1)C(=O)C=C)c1onc(c1C(=O)n1cc(C)c2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C32H29Cl3N4O5/c1-5-24(40)38-13-11-32(12-14-38,37(3)4)30-28(29(36-44-30)27-21(34)15-20(33)16-22(27)35)31(43)39-17-18(2)26-19(9-10-25(41)42)7-6-8-23(26)39/h5-10,15-17H,1,11-14H2,2-4H3,(H,41,42)/b10-9+	YHMDYZDSIMKOGF-MDZDMXLPSA-N	278664	US10040791, Example 126	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 37					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278664	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278664&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307185	378160258							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530142	OC(=O)\C=C1/CCc2cn(C(=O)c3c(onc3-c3c(Cl)cc(Cl)cc3Cl)C3CCN(CC3)C(=O)C=C)c3cccc1c23	InChI=1S/C31H24Cl3N3O5/c1-2-24(38)36-10-8-16(9-11-36)30-28(29(35-42-30)27-21(33)13-19(32)14-22(27)34)31(41)37-15-18-7-6-17(12-25(39)40)20-4-3-5-23(37)26(18)20/h2-5,12-16H,1,6-11H2,(H,39,40)/b17-12+	CMZJOEOPYWOXKF-SFQUDFHCSA-N	278665	US10040791, Example 127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 46					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278665	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278665&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307186	378160259							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530144	OC(=O)\C=C1/CCc2cn(C(=O)c3c(onc3-c3cc(F)c(Cl)cc3Cl)C3CCN(CC3)C(=O)C=C)c3cccc1c23	InChI=1S/C31H24Cl2FN3O5/c1-2-25(38)36-10-8-16(9-11-36)30-28(29(35-42-30)20-13-23(34)22(33)14-21(20)32)31(41)37-15-18-7-6-17(12-26(39)40)19-4-3-5-24(37)27(18)19/h2-5,12-16H,1,6-11H2,(H,39,40)/b17-12+	QNNPJOOJDDDDNY-SFQUDFHCSA-N	278666	US10040791, Example 128	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 38					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278666	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278666&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307036	378160260							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530146	Cc1cn(C(=O)c2c(onc2-c2ccc(Cl)c(F)c2Cl)C2CCN(CC2)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C30H24Cl2FN3O5/c1-3-22(37)35-13-11-18(12-14-35)29-25(28(34-41-29)19-8-9-20(31)27(33)26(19)32)30(40)36-15-16(2)24-17(7-10-23(38)39)5-4-6-21(24)36/h3-10,15,18H,1,11-14H2,2H3,(H,38,39)/b10-7+	ICCSHMQZNRTNRV-JXMROGBWSA-N	278667	US10040791, Example 129	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 85					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278667	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278667&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307201	378160261							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530148	OC(=O)\C=C1/CCc2cn(C(=O)c3c(onc3-c3ccc(Cl)c(F)c3Cl)C3CCN(CC3)C(=O)C=C)c3cccc1c23	InChI=1S/C31H24Cl2FN3O5/c1-2-23(38)36-12-10-16(11-13-36)30-26(29(35-42-30)20-8-9-21(32)28(34)27(20)33)31(41)37-15-18-7-6-17(14-24(39)40)19-4-3-5-22(37)25(18)19/h2-5,8-9,14-16H,1,6-7,10-13H2,(H,39,40)/b17-14+	QKYJFALUFVDGFL-SAPNQHFASA-N	278668	 (2E)-[1-{[5-(1-Acryloylpiperidin-4-yl)-3-(2,4-dichloro-3-fluorophenyl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzo[cd]indol-5(1H)-ylidene]ethanoic acid::US10040791, Example 130	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 60					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278668	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278668&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307192	378160262							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530150	OC(=O)\C=C1/CCc2cn(C(=O)c3c(onc3-c3ccc(Cl)cc3Cl)C3CCN(CC3)C(=O)C=C)c3cccc1c23	InChI=1S/C31H25Cl2N3O5/c1-2-25(37)35-12-10-17(11-13-35)30-28(29(34-41-30)22-9-8-20(32)15-23(22)33)31(40)36-16-19-7-6-18(14-26(38)39)21-4-3-5-24(36)27(19)21/h2-5,8-9,14-17H,1,6-7,10-13H2,(H,38,39)/b18-14+	TXEIQQMABKQWLJ-NBVRZTHBSA-N	278669	 (2E)-[1-{[5-(1-Acryloylpiperidin-4-yl)-3-(2,4-dichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzo[cd]indol-5(1H)-ylidene]ethanoic acid::US10040791, Example 131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 62					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278669	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278669&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307352	378160263							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530152	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(noc1-c1c(Cl)cc(Cl)cc1Cl)C1CCN(CC1)C(=O)C=C	InChI=1S/C29H22Cl3N3O5/c1-2-23(36)34-11-8-17(9-12-34)27-26(28(40-33-27)25-20(31)14-18(30)15-21(25)32)29(39)35-13-10-19-16(6-7-24(37)38)4-3-5-22(19)35/h2-7,10,13-15,17H,1,8-9,11-12H2,(H,37,38)/b7-6+	HPILQFSRJMCTKF-VOTSOKGWSA-N	278670	(2E)-3-(1-{[3-(1-Acryloylpiperidin-4-yl)-5-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 132	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 162					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278670	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278670&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307266	378160264							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530154	CN(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C23H17Cl2N3O4/c1-27(2)23-20(21(26-32-23)19-15(24)6-4-7-16(19)25)22(31)28-12-11-14-13(9-10-18(29)30)5-3-8-17(14)28/h3-12H,1-2H3,(H,29,30)/b10-9+	MMFAVRRGTJHELG-MDZDMXLPSA-N	278671	(2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(dimethylamino)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10.00					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278671	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278671&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307354	378160265							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530156	CCN(CC)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C25H21Cl2N3O4/c1-3-29(4-2)25-22(23(28-34-25)21-17(26)8-6-9-18(21)27)24(33)30-14-13-16-15(11-12-20(31)32)7-5-10-19(16)30/h5-14H,3-4H2,1-2H3,(H,31,32)/b12-11+	JFFOTDLLWGLPHG-VAWYXSNFSA-N	278672	 (2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(diethylamino)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 134	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 31					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278672	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278672&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307368	378160266							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530158	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cccc1Cl)N1CCCC1	InChI=1S/C25H19Cl2N3O4/c26-17-6-4-7-18(27)21(17)23-22(25(34-28-23)29-12-1-2-13-29)24(33)30-14-11-16-15(9-10-20(31)32)5-3-8-19(16)30/h3-11,14H,1-2,12-13H2,(H,31,32)/b10-9+	PNEPUQSOUVIVBT-MDZDMXLPSA-N	278673	 (2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(pyrrolidin-1-yl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 135	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278673	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278673&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307361	378160267							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530160	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(noc1N1CCOCC1)-c1c(Cl)cccc1Cl	InChI=1S/C25H19Cl2N3O5/c26-17-4-2-5-18(27)21(17)23-22(25(35-28-23)29-11-13-34-14-12-29)24(33)30-10-9-16-15(7-8-20(31)32)3-1-6-19(16)30/h1-10H,11-14H2,(H,31,32)/b8-7+	GTCIZPWDOPSRCT-BQYQJAHWSA-N	278674	 (2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(morpholin-4-yl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 136	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 27					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278674	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278674&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307037	378160268							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530162	C[C@H]1CCC[C@@H](C)N1c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C28H25Cl2N3O4/c1-16-6-3-7-17(2)33(16)28-25(26(31-37-28)24-20(29)9-5-10-21(24)30)27(36)32-15-14-19-18(12-13-23(34)35)8-4-11-22(19)32/h4-5,8-17H,3,6-7H2,1-2H3,(H,34,35)/b13-12+/t16-,17+	XZNPFKYVGHWAEQ-JZDNNTCESA-N	278675	(2E)-3-(1-{[3-(2,6-Dichlorophenyl)-5-(cis-2,6-dimethylpiperidin-1-yl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 137	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 28					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278675	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278675&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307359	378160269							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530164	CN(C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C23H16Cl3N3O4/c1-28(2)23-20(21(27-33-23)19-15(25)10-13(24)11-16(19)26)22(32)29-9-8-14-12(6-7-18(30)31)4-3-5-17(14)29/h3-11H,1-2H3,(H,30,31)/b7-6+	GTIQFOVRFAIMPD-VOTSOKGWSA-N	278676	 (2E)-3-(1-{[5-(Dimethylamino)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 138	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278676	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278676&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307196	378160270							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530166	NC[C@H]1CCN(C1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C26H22Cl2N4O4/c27-18-4-2-5-19(28)22(18)24-23(26(36-30-24)31-11-9-15(13-29)14-31)25(35)32-12-10-17-16(7-8-21(33)34)3-1-6-20(17)32/h1-8,10,12,15H,9,11,13-14,29H2,(H,33,34)/b8-7+/t15-/m1/s1	NUMWHIFQZLUUBP-MVGZEHJDSA-N	278677	(2E)-3-[1-({5-[(3R)-3-(Aminomethyl)pyrrolidin-1-yl]-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 139	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 183					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278677	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278677&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307371	378160271							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530168	NC[C@@H]1CCN(C1)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl	InChI=1S/C26H22Cl2N4O4/c27-18-4-2-5-19(28)22(18)24-23(26(36-30-24)31-11-9-15(13-29)14-31)25(35)32-12-10-17-16(7-8-21(33)34)3-1-6-20(17)32/h1-8,10,12,15H,9,11,13-14,29H2,(H,33,34)/b8-7+/t15-/m0/s1	NUMWHIFQZLUUBP-KIUWMYQTSA-N	278678	 (2E)-3[1-({5-[(3S)-3-(Aminomethyl)pyrrolidin-1-yl]-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 140	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 256					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278678	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278678&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307038	378160272							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530170	C[C@@H]1CN(CCN1c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl)C(=O)C=C	InChI=1S/C29H24Cl2N4O5/c1-3-23(36)33-14-15-34(17(2)16-33)29-26(27(32-40-29)25-20(30)7-5-8-21(25)31)28(39)35-13-12-19-18(10-11-24(37)38)6-4-9-22(19)35/h3-13,17H,1,14-16H2,2H3,(H,37,38)/b11-10+/t17-/m1/s1	QZOLGWIJLOKKGY-SXSDINLZSA-N	278679	(2E)-3-[1-({5-[(2R)-4-Acryloyl-2-methylpiperazin-1-yl]-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 141	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 160					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278679	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278679&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307048	378160273							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530172	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(noc1N1CCN(CC1)C(=O)C=C)-c1c(Cl)cccc1Cl	InChI=1S/C28H22Cl2N4O5/c1-2-22(35)32-13-15-33(16-14-32)28-25(26(31-39-28)24-19(29)6-4-7-20(24)30)27(38)34-12-11-18-17(9-10-23(36)37)5-3-8-21(18)34/h2-12H,1,13-16H2,(H,36,37)/b10-9+	JRZUMJQOESHEED-MDZDMXLPSA-N	278680	 (2E)-3-(1-{[5-(4-Acryloylpiperazin-1-yl)-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 142	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 83					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278680	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278680&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307197	378160274							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530174	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(noc1N1CCN(CC1)C(=O)C=C)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C28H21Cl3N4O5/c1-2-22(36)33-10-12-34(13-11-33)28-25(26(32-40-28)24-19(30)14-17(29)15-20(24)31)27(39)35-9-8-18-16(6-7-23(37)38)4-3-5-21(18)35/h2-9,14-15H,1,10-13H2,(H,37,38)/b7-6+	KKHDGMIUMMNJGD-VOTSOKGWSA-N	278681	 (2E)-3-(1-{[5-(4-Acryloylpiperazin-1-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 143	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 116					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278681	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278681&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307081	378160275							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530176	C[C@H]1CN(C[C@@H](C)N1c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl)C(=O)C=C	InChI=1S/C30H26Cl2N4O5/c1-4-24(37)34-15-17(2)36(18(3)16-34)30-27(28(33-41-30)26-21(31)8-6-9-22(26)32)29(40)35-14-13-20-19(11-12-25(38)39)7-5-10-23(20)35/h4-14,17-18H,1,15-16H2,2-3H3,(H,38,39)/b12-11+/t17-,18+	IUPMKLXZXSGEEK-JZYAGYNQSA-N	278682	 (2E)-3-(1-{[5-(4-Acryloyl-cis-2,6-dimethylpiperazin-1-yl)-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 144	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 71					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278682	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278682&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307079	378160276							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530178	C[C@H]1CN(CCN1c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl)C(=O)C=C	InChI=1S/C29H24Cl2N4O5/c1-3-23(36)33-14-15-34(17(2)16-33)29-26(27(32-40-29)25-20(30)7-5-8-21(25)31)28(39)35-13-12-19-18(10-11-24(37)38)6-4-9-22(19)35/h3-13,17H,1,14-16H2,2H3,(H,37,38)/b11-10+/t17-/m0/s1	QZOLGWIJLOKKGY-DVQDXYAYSA-N	278683	 (2E)-3-[1-({5-[(2S)-4-Acryloyl-2-methylpiperazin-1-yl]-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 80					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278683	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278683&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307080	378160277							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530180	C[C@H]1CN(CCN1c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl)C(=O)C=C	InChI=1S/C29H23Cl3N4O5/c1-3-23(37)34-11-12-35(16(2)15-34)29-26(27(33-41-29)25-20(31)13-18(30)14-21(25)32)28(40)36-10-9-19-17(7-8-24(38)39)5-4-6-22(19)36/h3-10,13-14,16H,1,11-12,15H2,2H3,(H,38,39)/b8-7+/t16-/m0/s1	HGTWIFFSNDPQBH-WAVCKPEOSA-N	278684	 (2E)-3-[1-({5-[(2R)-4-Acryloyl-2-methylpiperazin-1-yl]-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 146	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 176					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278684	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278684&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132070950	378160278							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530182	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cccc1Cl)N1CCN(CC11CC1)C(=O)C=C	InChI=1S/C30H24Cl2N4O5/c1-2-23(37)34-15-16-36(30(17-34)12-13-30)29-26(27(33-41-29)25-20(31)6-4-7-21(25)32)28(40)35-14-11-19-18(9-10-24(38)39)5-3-8-22(19)35/h2-11,14H,1,12-13,15-17H2,(H,38,39)/b10-9+	KADALMMGLFJRDG-MDZDMXLPSA-N	278685	 (2E)-3-(1-{[5-[7-Acryloyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 147	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278685	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278685&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307056	378160279							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530184	C[C@@H]1CN(CCN1C(=O)C=C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C29H23Cl3N4O5/c1-3-23(37)35-12-11-34(15-16(35)2)29-26(27(33-41-29)25-20(31)13-18(30)14-21(25)32)28(40)36-10-9-19-17(7-8-24(38)39)5-4-6-22(19)36/h3-10,13-14,16H,1,11-12,15H2,2H3,(H,38,39)/b8-7+/t16-/m1/s1	SIWWMHDNRFCNDE-KXPUMZMLSA-N	278686	 (2E)-3-[1-({5-[(3R)-4-Acryloyl-3-methylpiperazin-1-yl]3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 148	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 167					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278686	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278686&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130311619	378160280							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530186	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(noc1N1CCN(CC1)S(=O)(=O)C=C)-c1c(Cl)cccc1Cl	InChI=1S/C27H22Cl2N4O6S/c1-2-40(37,38)32-15-13-31(14-16-32)27-24(25(30-39-27)23-19(28)6-4-7-20(23)29)26(36)33-12-11-18-17(9-10-22(34)35)5-3-8-21(18)33/h2-12H,1,13-16H2,(H,34,35)/b10-9+	DBJFRGCDXOKEGT-MDZDMXLPSA-N	278687	 (2E)-3-[1-({3-(2,6-Dichlorophenyl)-5-[4-(ethenylsulfonyl)piperazin-1-yl]-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 16					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278687	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278687&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307366	378160281							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530188	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cc(Cl)cc1Cl)N1CCN(CC11CC1)C(=O)C=C	InChI=1S/C30H23Cl3N4O5/c1-2-23(38)35-12-13-37(30(16-35)9-10-30)29-26(27(34-42-29)25-20(32)14-18(31)15-21(25)33)28(41)36-11-8-19-17(6-7-24(39)40)4-3-5-22(19)36/h2-8,11,14-15H,1,9-10,12-13,16H2,(H,39,40)/b7-6+	FOLZMPFXCMRKTM-VOTSOKGWSA-N	278688	 (2E)-3-(1-{[5-[7-Acryloyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 150	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 26					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278688	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278688&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307215	378160282							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530190	C[C@H]1CN(C[C@@H](C)N1c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl)C(=O)C=C	InChI=1S/C30H25Cl3N4O5/c1-4-24(38)35-14-16(2)37(17(3)15-35)30-27(28(34-42-30)26-21(32)12-19(31)13-22(26)33)29(41)36-11-10-20-18(8-9-25(39)40)6-5-7-23(20)36/h4-13,16-17H,1,14-15H2,2-3H3,(H,39,40)/b9-8+/t16-,17+	YCTWCFULURHWLP-CWNHSUMWSA-N	278689	 (2E)-3-(1-{[5-(4-Acryloyl-cis-2,6-dimethylpiperazin-1-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 151	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 98					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278689	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278689&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307199	378160283							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530192	C[C@@H]1CN([C@H](C)CN1C(=O)C=C)c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cc(Cl)cc1Cl	InChI=1S/C30H25Cl3N4O5/c1-4-24(38)36-14-17(3)37(15-16(36)2)30-27(28(34-42-30)26-21(32)12-19(31)13-22(26)33)29(41)35-11-10-20-18(8-9-25(39)40)6-5-7-23(20)35/h4-13,16-17H,1,14-15H2,2-3H3,(H,39,40)/b9-8+/t16-,17-/m1/s1	ZTABWOUHCSEFHZ-PIIXRYACSA-N	278690	 (2E)-3-[1-({5-[(2R,5R)-4-Acryloyl-2,5-dimethylpiperazin-1-yl]-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl} carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 152	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 144					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278690	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278690&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307268	378160284							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530194	CC1(C)CN(CCN1c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl)C(=O)C=C	InChI=1S/C30H26Cl2N4O5/c1-4-23(37)34-15-16-36(30(2,3)17-34)29-26(27(33-41-29)25-20(31)8-6-9-21(25)32)28(40)35-14-13-19-18(11-12-24(38)39)7-5-10-22(19)35/h4-14H,1,15-17H2,2-3H3,(H,38,39)/b12-11+	AGNMUVJZIKIIGO-VAWYXSNFSA-N	278691	 (2E)-3-(1-{[5-(4-Acryloyl-2,2-dimethylpiperazin-1-yl)-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 88					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278691	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278691&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307219	378160285							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530196	OC(=O)\C=C\c1cccc2n(ccc12)C(=O)c1c(onc1-c1c(Cl)cccc1Cl)N1CCN(C[C@H]1C1CC1)C(=O)C=C	InChI=1S/C31H26Cl2N4O5/c1-2-25(38)35-15-16-37(24(17-35)19-9-10-19)31-28(29(34-42-31)27-21(32)6-4-7-22(27)33)30(41)36-14-13-20-18(11-12-26(39)40)5-3-8-23(20)36/h2-8,11-14,19,24H,1,9-10,15-17H2,(H,39,40)/b12-11+/t24-/m0/s1	IVRTWLTWACZOFF-LCJITAHGSA-N	278692	 (2E)-3-[1-({5-[(2R)-4-Acryloyl-2-cyclopropylpiperazin-1-yl]-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 154	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 299					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278692	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278692&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307221	378160286							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530198	C[C@@H]1CN(c2onc(c2C(=O)n2ccc3c(\C=C\C(O)=O)cccc23)-c2c(Cl)cccc2Cl)C2(CC2)CN1C(=O)C=C	InChI=1S/C31H26Cl2N4O5/c1-3-24(38)36-17-31(13-14-31)37(16-18(36)2)30-27(28(34-42-30)26-21(32)7-5-8-22(26)33)29(41)35-15-12-20-19(10-11-25(39)40)6-4-9-23(20)35/h3-12,15,18H,1,13-14,16-17H2,2H3,(H,39,40)/b11-10+/t18-/m1/s1	YNMYTTWXBCEWBD-DOJUMQAQSA-N	278693	 (2E)-3-[1-({5-[(6R)7-Acryloyl-6-methyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 155	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278693	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278693&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307224	378160287							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530200	C[C@@H]1CN(c2onc(c2C(=O)n2ccc3c(\C=C\C(O)=O)cccc23)-c2c(F)cccc2Cl)C2(CC2)CN1C(=O)C=C	InChI=1S/C31H26ClFN4O5/c1-3-24(38)36-17-31(13-14-31)37(16-18(36)2)30-27(28(34-42-30)26-21(32)7-5-8-22(26)33)29(41)35-15-12-20-19(10-11-25(39)40)6-4-9-23(20)35/h3-12,15,18H,1,13-14,16-17H2,2H3,(H,39,40)/b11-10+/t18-/m1/s1	HNRBYJFAXWNXLU-DOJUMQAQSA-N	278694	 (2E)-3-[1-({5-[(6R)7-Acryloyl-6-methyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2-chloro-6-fluorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 156	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 41					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278694	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278694&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307207	378160288							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530202	CC1(C)CN(CCN1c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(F)cccc1Cl)C(=O)C=C	InChI=1S/C30H26ClFN4O5/c1-4-23(37)34-15-16-36(30(2,3)17-34)29-26(27(33-41-29)25-20(31)8-6-9-21(25)32)28(40)35-14-13-19-18(11-12-24(38)39)7-5-10-22(19)35/h4-14H,1,15-17H2,2-3H3,(H,38,39)/b12-11+	QBTZFZVPUDMQES-VAWYXSNFSA-N	278695	 (2E)-3-(1-{[5-(4-Acryloyl-2,2-dimethylpiperazin-1-yl)-3-(2-chloro-6-fluorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-4-yl)prop-2-enoic acid::US10040791, Example 157	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 314					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278695	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278695&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307209	378160289							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530204	COc1cccc(Cl)c1-c1noc(N2C[C@@H](C)N(CC22CC2)C(=O)C=C)c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12	InChI=1S/C32H29ClN4O6/c1-4-25(38)36-18-32(14-15-32)37(17-19(36)2)31-28(29(34-43-31)27-22(33)8-6-10-24(27)42-3)30(41)35-16-13-21-20(11-12-26(39)40)7-5-9-23(21)35/h4-13,16,19H,1,14-15,17-18H2,2-3H3,(H,39,40)/b12-11+/t19-/m1/s1	FZEVZYHOOKBFAQ-TZZQJPOUSA-N	278696	 (2E)-3-[1-({5-[(6R)7-Acryloyl-6-methyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2-chloro-6-methoxyphenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 158	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 64					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278696	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278696&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307269	378160290							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530206	C[C@@H]1CN(CC2(CC2)N1c1onc(c1C(=O)n1ccc2c(\C=C\C(O)=O)cccc12)-c1c(Cl)cccc1Cl)C(=O)C=C	InChI=1S/C31H26Cl2N4O5/c1-3-24(38)35-16-18(2)37(31(17-35)13-14-31)30-27(28(34-42-30)26-21(32)7-5-8-22(26)33)29(41)36-15-12-20-19(10-11-25(39)40)6-4-9-23(20)36/h3-12,15,18H,1,13-14,16-17H2,2H3,(H,39,40)/b11-10+/t18-/m1/s1	WTRJIQMMQXVJTR-DOJUMQAQSA-N	278697	 (2E)-3-[1-({5-[(5R)7-Acryloyl-5-methyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 159	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278697	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278697&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307058	378160291							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530208	CC[C@@H]1CN(c2onc(c2C(=O)n2ccc3c(\C=C\C(O)=O)cccc23)-c2c(F)cccc2Cl)C2(CC2)CN1C(=O)C=C	InChI=1S/C32H28ClFN4O5/c1-3-20-17-38(32(14-15-32)18-37(20)25(39)4-2)31-28(29(35-43-31)27-22(33)8-6-9-23(27)34)30(42)36-16-13-21-19(11-12-26(40)41)7-5-10-24(21)36/h4-13,16,20H,2-3,14-15,17-18H2,1H3,(H,40,41)/b12-11+/t20-/m1/s1	XKYRKDXEEDGAFF-YVNCXZRQSA-N	278698	 (2E)-3-[1-({5-[(6R)7-Acryloyl-6-ethyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2-chloro-6-fluorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 160	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 26					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278698	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278698&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307061	378160292							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530210	CC[C@@H]1CN(c2onc(c2C(=O)n2ccc3c(\C=C\C(O)=O)cccc23)-c2c(Cl)cccc2OC)C2(CC2)CN1C(=O)C=C	InChI=1S/C33H31ClN4O6/c1-4-21-18-38(33(15-16-33)19-37(21)26(39)5-2)32-29(30(35-44-32)28-23(34)9-7-11-25(28)43-3)31(42)36-17-14-22-20(12-13-27(40)41)8-6-10-24(22)36/h5-14,17,21H,2,4,15-16,18-19H2,1,3H3,(H,40,41)/b13-12+/t21-/m1/s1	MTTSULIETFPACO-JNCYCUAHSA-N	278699	 (2E)-3-[1-({5-{(6R)7-Acryloyl-6-ethyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2-chloro-6-methoxyphenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 35					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278699	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278699&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307367	378160293							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530212	C[C@@H]1CN(c2onc(c2C(=O)n2cc(C)c3c(\C=C\C(O)=O)cccc23)-c2c(F)cccc2Cl)C2(CC2)CN1C(=O)C=C	InChI=1S/C32H28ClFN4O5/c1-4-24(39)37-17-32(13-14-32)38(16-19(37)3)31-28(29(35-43-31)27-21(33)8-6-9-22(27)34)30(42)36-15-18(2)26-20(11-12-25(40)41)7-5-10-23(26)36/h4-12,15,19H,1,13-14,16-17H2,2-3H3,(H,40,41)/b12-11+/t19-/m1/s1	IQCLBTXWISQULI-TZZQJPOUSA-N	278700	 (2E)-3-[1-({5-[(6R)7-Acryloyl-6-methyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2-chloro-6-fluorophenyl)-1,2-oxazol-4-yl}carbonyl)-3-methyl-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 162	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278700	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278700&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307084	378160294							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530214	CC[C@@H]1CN(c2onc(c2C(=O)n2ccc3c(\C=C\C(O)=O)cccc23)-c2c(Cl)cccc2Cl)C2(CC2)CN1C(=O)C=C	InChI=1S/C32H28Cl2N4O5/c1-3-20-17-38(32(14-15-32)18-37(20)25(39)4-2)31-28(29(35-43-31)27-22(33)8-6-9-23(27)34)30(42)36-16-13-21-19(11-12-26(40)41)7-5-10-24(21)36/h4-13,16,20H,2-3,14-15,17-18H2,1H3,(H,40,41)/b12-11+/t20-/m1/s1	RUYCHNOTZLQFMC-YVNCXZRQSA-N	278701	 (2E)-3-[1-({5-[(6R)7-Acryloyl-6-ethyl-4,7-diazaspiro[2.5]oct-4-yl]-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl}carbonyl)-1H-indol-4-yl]prop-2-enoic acid::US10040791, Example 163	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 16					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278701	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278701&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307374	378160295							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530216	Cn1cc(C(=O)c2c(noc2C(C)(C)C)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H21Cl3N2O4/c1-26(2,3)25-21(22(30-35-25)20-17(28)10-14(27)11-18(20)29)24(34)16-12-31(4)23-13(8-9-19(32)33)6-5-7-15(16)23/h5-12H,1-4H3,(H,32,33)/b9-8+	KMKQLYWDTOLCEJ-CMDGGOBGSA-N	278702	(2E)-3-(3-[5-tert-Butyl-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1-methyl-1H-indol-7-yl)prop-2-enoic acid::US10040791, Example 164	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278702	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278702&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307238	378160296							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530218	Cn1cc(C(=O)c2c(noc2C2(C)CC2)-c2c(Cl)cc(Cl)cc2Cl)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C26H19Cl3N2O4/c1-26(8-9-26)25-21(22(30-35-25)20-17(28)10-14(27)11-18(20)29)24(34)16-12-31(2)23-13(6-7-19(32)33)4-3-5-15(16)23/h3-7,10-12H,8-9H2,1-2H3,(H,32,33)/b7-6+	KDZZPEPBMYAXLB-VOTSOKGWSA-N	278703	 (2E)-3-(1-Methyl-3-{[5-(1-methylcyclopropyl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1H-indol-7-yl)prop-2-enoic acid::US10040791, Example 165	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10.00					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278703	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278703&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307085	378160297							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530220	Cn1cc(C(=O)c2c(onc2-c2c(Cl)cc(Cl)cc2Cl)C2CCN(CC2)C(=O)C=C)c2cccc(\C=C\C(O)=O)c12	InChI=1S/C30H24Cl3N3O5/c1-3-23(37)36-11-9-17(10-12-36)30-26(27(34-41-30)25-21(32)13-18(31)14-22(25)33)29(40)20-15-35(2)28-16(7-8-24(38)39)5-4-6-19(20)28/h3-8,13-15,17H,1,9-12H2,2H3,(H,38,39)/b8-7+	VHTMFXILPVFQDZ-BQYQJAHWSA-N	278704	(2E)-3-(3-{[5-(1-Acryloylpiperidin-4-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1-methyl-1H-indol-7-yl)prop-2-enoic acid::US10040791, Example 166	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 54					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278704	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278704&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307211	378160298							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
530222	Cn1cc(C(=O)c2c(noc2C(C)(C)C)-c2c(Cl)cc(Cl)cc2Cl)c2ccc3ccc(cc3c12)C(O)=O	InChI=1S/C28H21Cl3N2O4/c1-28(2,3)26-22(23(32-37-26)21-19(30)10-15(29)11-20(21)31)25(34)18-12-33(4)24-16(18)8-7-13-5-6-14(27(35)36)9-17(13)24/h5-12H,1-4H3,(H,35,36)	PSGMVWXGZRFBCU-UHFFFAOYSA-N	278705	3-{[5-tert-Butyl-3-(2,4,6-trichlorophenyl)-1,2-oxazol-4-yl]carbonyl}-1-methyl-1H-benzo[g]indole-8-carboxylic acid::US10040791, Example 167	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 37					7.5	25.00 C	US Patent		10.7270/Q2JS9SF8		aid1795562	US10040791	Saito, S; Itoh, M; Fujisawa, T; Saito, H; Kiyotsuka, Y; Watanabe, H; Matsunaga, H; Kagoshima, Y; Suzuki, T; Ogawara, Y; Kitabayashi, K	8/7/2018	12/22/2018	Daiichi Sankyo Company, Limited	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=278705	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=278705&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130307271	378160299							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531925	C[C@]1(COCC(N)=N1)c1cccc(NC(=O)c2ccc(Br)cn2)n1	InChI=1S/C16H16BrN5O2/c1-16(9-24-8-13(18)22-16)12-3-2-4-14(20-12)21-15(23)11-6-5-10(17)7-19-11/h2-7H,8-9H2,1H3,(H2,18,22)(H,20,21,23)/t16-/m0/s1	WQUQHUCOJVZXJC-INIZCTEOSA-N	116227	US10035794, Example 1::US10683287, Example 1::US8637508, 1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 41.0							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116227&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70356238	199996611							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531926	CC1(COCC(N)=N1)c1cccc(NC(=O)c2ccc(Br)cn2)n1	InChI=1S/C16H16BrN5O2/c1-16(9-24-8-13(18)22-16)12-3-2-4-14(20-12)21-15(23)11-6-5-10(17)7-19-11/h2-7H,8-9H2,1H3,(H2,18,22)(H,20,21,23)	WQUQHUCOJVZXJC-UHFFFAOYSA-N	116228	US10035794, Example 2::US10683287, Example 2::US8637508, 2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 58.0							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116228&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			57523959	199996612							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531927	NC1=NC(CF)(COC1)c1cccc(NC(=O)c2ccc(Cl)cn2)n1	InChI=1S/C16H15ClFN5O2/c17-10-4-5-11(20-6-10)15(24)22-14-3-1-2-12(21-14)16(8-18)9-25-7-13(19)23-16/h1-6H,7-9H2,(H2,19,23)(H,21,22,24)	CDJHOYHFBRGWII-UHFFFAOYSA-N	279659	5-{6-[(5-Chloro-pyridine-2-carbonyl)-amino]-pyridin-2-yl}-5-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl-ammonium trifluoro acetate::US10035794, Example 3	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 140							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279659	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279659&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			57523960	378161234							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531928	[NH3+]C1=NC(CF)(COC1)c1cccc(NC(=O)c2ccc(Br)cn2)n1	InChI=1S/C16H15BrFN5O2/c17-10-4-5-11(20-6-10)15(24)22-14-3-1-2-12(21-14)16(8-18)9-25-7-13(19)23-16/h1-6H,7-9H2,(H2,19,23)(H,21,22,24)/p+1	HBAGGGIQIJILPN-UHFFFAOYSA-O	116230	BDBM279660::US10683287, Example 4::US8637508, 4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 98.0							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116230&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			91808726	199996614							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531929	Cc1cc(cnc1C(=O)Nc1cccc(n1)C1(CF)COCC([NH3+])=N1)C#N	InChI=1S/C18H17FN6O2/c1-11-5-12(6-20)7-22-16(11)17(26)24-15-4-2-3-13(23-15)18(9-19)10-27-8-14(21)25-18/h2-5,7H,8-10H2,1H3,(H2,21,25)(H,23,24,26)/p+1	DQUIQKUFQPXKNE-UHFFFAOYSA-O	116231	BDBM279661::US8637508, 5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 40.0							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116231&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			91808727	199996615							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531930	Cc1cc(Cl)cnc1C(=O)Nc1cccc(n1)C1(CF)COCC([NH3+])=N1	InChI=1S/C17H17ClFN5O2/c1-10-5-11(18)6-21-15(10)16(25)23-14-4-2-3-12(22-14)17(8-19)9-26-7-13(20)24-17/h2-6H,7-9H2,1H3,(H2,20,24)(H,22,23,25)/p+1	OEZZKNFURPODDF-UHFFFAOYSA-O	279662	US10035794, Example 6	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 63.0							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279662	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279662&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			136214975	378161237							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531931	NC(=S)c1ccc(nc1)C(=O)Nc1cccc(n1)C1(CF)COCC([NH3+])=N1	InChI=1S/C17H17FN6O2S.C2HF3O2/c18-8-17(9-26-7-13(19)24-17)12-2-1-3-14(22-12)23-16(25)11-5-4-10(6-21-11)15(20)27;3-2(4,5)1(6)7/h1-6H,7-9H2,(H2,19,24)(H2,20,27)(H,22,23,25);(H,6,7)	IBRIMKZFABBPMR-UHFFFAOYSA-N	279663	US10035794, Example 7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 640							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279663	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279663&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			136277826	378161238							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531932	Cc1cc(cnc1C(=O)Nc1cccc(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H19F3N6O2/c1-11-7-12(8-24)9-26-15(11)16(30)28-14-6-4-5-13(27-14)18(2)10-31-19(3,17(25)29-18)20(21,22)23/h4-7,9H,10H2,1-3H3,(H2,25,29)(H,27,28,30)/t18-,19+/m0/s1	HONUCNWSWWNZSP-RBUKOAKNSA-N	116233	US10035794, Example 8::US10683287, Example 8::US8637508, 8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 6.00							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116233&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70356349	199996617							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531933	C[C@@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ccc(cn2)C#N)n1	InChI=1S/C19H17F3N6O2/c1-17(10-30-18(2,16(24)28-17)19(20,21)22)13-4-3-5-14(26-13)27-15(29)12-7-6-11(8-23)9-25-12/h3-7,9H,10H2,1-2H3,(H2,24,28)(H,26,27,29)/t17-,18-/m1/s1	QSCBNUCKFXAIJL-QZTJIDSGSA-N	116234	BDBM279665::US8637508, 9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1900							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116234&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70355899	199996618							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531934	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ccc(cn2)C#N)n1	InChI=1S/C19H17F3N6O2/c1-17(10-30-18(2,16(24)28-17)19(20,21)22)13-4-3-5-14(26-13)27-15(29)12-7-6-11(8-23)9-25-12/h3-7,9H,10H2,1-2H3,(H2,24,28)(H,26,27,29)/t17-,18+/m0/s1	QSCBNUCKFXAIJL-ZWKOTPCHSA-N	116235	US10035794, Example 10::US10683287, Example 10::US8637508, 10	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17.0							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116235&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89951951	199996619							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531935	Cc1cc(cnc1C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H18F4N6O2/c1-10-6-11(7-25)8-27-14(10)16(31)29-13-5-4-12(21)15(28-13)18(2)9-32-19(3,17(26)30-18)20(22,23)24/h4-6,8H,9H2,1-3H3,(H2,26,30)(H,28,29,31)/t18-,19+/m0/s1	MTNQDQUYJFDVLS-RBUKOAKNSA-N	116236	US10035794, Example 11::US10683287, Example 11::US8637508, 11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2.00							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116236	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116236&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70356221	199996620							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531936	Cc1cc(cnc1C(=O)Nc1ccc(F)c(n1)[C@@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H18F4N6O2/c1-10-6-11(7-25)8-27-14(10)16(31)29-13-5-4-12(21)15(28-13)18(2)9-32-19(3,17(26)30-18)20(22,23)24/h4-6,8H,9H2,1-3H3,(H2,26,30)(H,28,29,31)/t18-,19-/m1/s1	MTNQDQUYJFDVLS-RTBURBONSA-N	116237	US10035794, Example 12::US10683287, Example 12::US8637508, 12	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 280							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116237&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70355933	199996621							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531937	Cc1cc(Cl)cnc1C(=O)Nc1cc(ccn1)C1(CF)COCC(N)=N1	InChI=1S/C17H17ClFN5O2/c1-10-4-12(18)6-22-15(10)16(25)23-14-5-11(2-3-21-14)17(8-19)9-26-7-13(20)24-17/h2-6H,7-9H2,1H3,(H2,20,24)(H,21,23,25)	OLVSRIFVQCSRTD-UHFFFAOYSA-N	279669	5-{2-[(5-Chloro-4,6-dideutero-3-trideuteromethyl-pyridine-2-carbonyl)-amino]-pyridin-4-yl}-5-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl-ammonium acetate::US10035794, Example 13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279669	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279669&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			76555410	378161244							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531938	[NH3+]C1=NC(CF)(COC1)c1ccnc(NC(=O)c2ccc(Cl)cn2)c1	InChI=1S/C16H15ClFN5O2/c17-11-1-2-12(21-6-11)15(24)22-14-5-10(3-4-20-14)16(8-18)9-25-7-13(19)23-16/h1-6H,7-9H2,(H2,19,23)(H,20,22,24)/p+1	GPJQSUWRIBDPMP-UHFFFAOYSA-O	116238	BDBM279670::US10683287, Example 14::US8637508, 14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 660							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116238	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116238&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			91808729	199996622							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531939	Cc1cc(cnc1C(=O)Nc1cc(c(F)cn1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H18F4N6O2/c1-10-4-11(6-25)7-28-15(10)16(31)29-14-5-12(13(21)8-27-14)18(2)9-32-19(3,17(26)30-18)20(22,23)24/h4-5,7-8H,9H2,1-3H3,(H2,26,30)(H,27,29,31)/t18-,19+/m0/s1	VAFUDQUXHDFJQT-RBUKOAKNSA-N	116240	US10035794, Example 16::US10683287, Example 16::US8637508, 16	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 77.0							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116240&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70356350	199996624							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531940	Cc1cc(cnc1C(=O)Nc1cc(c(F)cn1)[C@@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F)C#N	InChI=1S/C20H18F4N6O2/c1-10-4-11(6-25)7-28-15(10)16(31)29-14-5-12(13(21)8-27-14)18(2)9-32-19(3,17(26)30-18)20(22,23)24/h4-5,7-8H,9H2,1-3H3,(H2,26,30)(H,27,29,31)/t18-,19-/m1/s1	VAFUDQUXHDFJQT-RTBURBONSA-N	116241	US10035794, Example 17::US10683287, Example 17::US8637508, 17	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4800							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116241&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70356355	199996625							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531941	NC1=NC(CF)(COC1)c1cc(NC(=O)c2ccc(Br)cn2)cnc1Cl	InChI=1S/C16H14BrClFN5O2.ClH/c17-9-1-2-12(21-4-9)15(25)23-10-3-11(14(18)22-5-10)16(7-19)8-26-6-13(20)24-16;/h1-5H,6-8H2,(H2,20,24)(H,23,25);1H	GOPQMKFOQHZZCI-UHFFFAOYSA-N	279674	5-Bromo-pyridine-2-carboxylic acid [5-(5-amino-3-fluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-6-chloro-pyridin-3-yl]-amide hydrochloride::US10035794, Example 18	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 15.0							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279674	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279674&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			57524139	378161249							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531942	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ncc(cc2N)C#N)n1	InChI=1S/C19H18F3N7O2/c1-17(9-31-18(2,16(25)29-17)19(20,21)22)12-4-3-5-13(27-12)28-15(30)14-11(24)6-10(7-23)8-26-14/h3-6,8H,9,24H2,1-2H3,(H2,25,29)(H,27,28,30)/t17-,18+/m0/s1	QLMSSDKIDFGJDT-ZWKOTPCHSA-N	116243	US10035794, Example 19::US10683287, Example 19::US8637508, 19	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 48.0							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116243	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116243&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70355685	199996627							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531943	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ncc(cc2Cl)C#N)n1	InChI=1S/C19H16ClF3N6O2/c1-17(9-31-18(2,16(25)29-17)19(21,22)23)12-4-3-5-13(27-12)28-15(30)14-11(20)6-10(7-24)8-26-14/h3-6,8H,9H2,1-2H3,(H2,25,29)(H,27,28,30)/t17-,18+/m0/s1	DPIDWDAWIQYLLV-ZWKOTPCHSA-N	116244	US10035794, Example 20::US10683287, Example 20::US8637508, 20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5.00							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116244&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70356253	199996628							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531944	Cc1cc(Cl)cnc1C(=O)Nc1cccc(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F	InChI=1S/C19H19ClF3N5O2/c1-10-7-11(20)8-25-14(10)15(29)27-13-6-4-5-12(26-13)17(2)9-30-18(3,16(24)28-17)19(21,22)23/h4-8H,9H2,1-3H3,(H2,24,28)(H,26,27,29)/t17-,18+/m0/s1	MGXZYVPDNLXFNB-ZWKOTPCHSA-N	279677	US10035794, Example 21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 110							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279677	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279677&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			136214979	378161252							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531945	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ncc(Br)cc2Cl)n1	InChI=1S/C18H16BrClF3N5O2/c1-16(8-30-17(2,15(24)28-16)18(21,22)23)11-4-3-5-12(26-11)27-14(29)13-10(20)6-9(19)7-25-13/h3-7H,8H2,1-2H3,(H2,24,28)(H,26,27,29)/t16-,17+/m0/s1	VANDNQQVYPKEOC-DLBZAZTESA-N	116245	US10035794, Example 22::US10683287, Example 22::US8637508, 22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29.0							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116245	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116245&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70356247	199996629							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531946	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cccc(NC(=O)c2ncc(OCC(F)(F)F)nc2N)n1	InChI=1S/C19H19F6N7O3/c1-16(7-35-17(2,15(27)32-16)19(23,24)25)9-4-3-5-10(29-9)30-14(33)12-13(26)31-11(6-28-12)34-8-18(20,21)22/h3-6H,7-8H2,1-2H3,(H2,26,31)(H2,27,32)(H,29,30,33)/t16-,17+/m0/s1	FFRBKRVVRVORIQ-DLBZAZTESA-N	116246	US10035794, Example 23::US8637508, 23	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 700							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116246	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116246&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			88602533	199996630							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531947	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C#N)ccc1F	InChI=1S/C19H15ClF4N6O2/c1-17(8-32-18(2,16(26)30-17)19(22,23)24)14-11(21)3-4-12(28-14)29-15(31)13-10(20)5-9(6-25)7-27-13/h3-5,7H,8H2,1-2H3,(H2,26,30)(H,28,29,31)/t17-,18+/m0/s1	LHTZVIDMVHFLLF-ZWKOTPCHSA-N	116247	US10035794, Example 24::US10683287, Example 35::US8637508, 24	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3.00							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116247	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116247&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70355131	199996631							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531948	COc1cnc(C(=O)Nc2ccc(F)c(n2)[C@]2(C)CO[C@](C)(C(N)=N2)C(F)(F)F)c(C)c1	InChI=1S/C20H21F4N5O3/c1-10-7-11(31-4)8-26-14(10)16(30)28-13-6-5-12(21)15(27-13)18(2)9-32-19(3,17(25)29-18)20(22,23)24/h5-8H,9H2,1-4H3,(H2,25,29)(H,27,28,30)/t18-,19+/m0/s1	PWIJFDYDPIMSCV-RBUKOAKNSA-N	116248	US10035794, Example 25::US10683287, Example 25::US8637508, 25	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 76.0							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116248	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116248&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70356220	199996632							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531949	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(OCC(F)(F)F)nc2N)ccc1F	InChI=1S/C19H18F7N7O3/c1-16(6-36-17(2,15(28)33-16)19(24,25)26)12-8(20)3-4-9(30-12)31-14(34)11-13(27)32-10(5-29-11)35-7-18(21,22)23/h3-5H,6-7H2,1-2H3,(H2,27,32)(H2,28,33)(H,30,31,34)/t16-,17+/m0/s1	FKENLPZVPNVYQW-DLBZAZTESA-N	116249	US10035794, Example 26::US8637508, 26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 280							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116249	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116249&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			88602362	199996633							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531950	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(cc2N)C#N)ccc1F	InChI=1S/C19H17F4N7O2/c1-17(8-32-18(2,16(26)30-17)19(21,22)23)14-10(20)3-4-12(28-14)29-15(31)13-11(25)5-9(6-24)7-27-13/h3-5,7H,8,25H2,1-2H3,(H2,26,30)(H,28,29,31)/t17-,18+/m0/s1	MWIIPGZITGHTPU-ZWKOTPCHSA-N	116250	US10035794, Example 27::US10683287, Example 27::US8637508, 27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5.00							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116250	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116250&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89951901	199996634							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531951	Cc1cc(OC(F)F)cnc1C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F	InChI=1S/C20H19F6N5O3/c1-9-6-10(34-17(22)23)7-28-13(9)15(32)30-12-5-4-11(21)14(29-12)18(2)8-33-19(3,16(27)31-18)20(24,25)26/h4-7,17H,8H2,1-3H3,(H2,27,31)(H,29,30,32)/t18-,19+/m0/s1	IEGJECJTLOSIQV-RBUKOAKNSA-N	116252	US10035794, Example 29::US10683287, Example 30::US8637508, 29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 24.0							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116252	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116252&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			88602949	199996636							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531952	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(OC(F)F)cc2Cl)ccc1F	InChI=1S/C19H16ClF6N5O3/c1-17(7-33-18(2,15(27)31-17)19(24,25)26)13-10(21)3-4-11(29-13)30-14(32)12-9(20)5-8(6-28-12)34-16(22)23/h3-6,16H,7H2,1-2H3,(H2,27,31)(H,29,30,32)/t17-,18+/m0/s1	DOJQNRYLSRMQDA-ZWKOTPCHSA-N	116253	US10035794, Example 30::US10683287, Example 36::US8637508, 30	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 24.0							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116253	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116253&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89951915	199996637							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531953	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(Cl)cc2Cl)ccc1F	InChI=1S/C18H15Cl2F4N5O2/c1-16(7-31-17(2,15(25)29-16)18(22,23)24)13-10(21)3-4-11(27-13)28-14(30)12-9(20)5-8(19)6-26-12/h3-6H,7H2,1-2H3,(H2,25,29)(H,27,28,30)/t16-,17+/m0/s1	DRKAFGKWERJHKK-DLBZAZTESA-N	116254	US10035794, Example 31::US10683287, Example 31::US8637508, 31	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10.00							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116254	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116254&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89951906	199996638							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531954	Cc1cc(OCF)cnc1C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F	InChI=1S/C20H20F5N5O3/c1-10-6-11(32-9-21)7-27-14(10)16(31)29-13-5-4-12(22)15(28-13)18(2)8-33-19(3,17(26)30-18)20(23,24)25/h4-7H,8-9H2,1-3H3,(H2,26,30)(H,28,29,31)/t18-,19+/m0/s1	VZKUTAXMEIXBFQ-RBUKOAKNSA-N	116255	US10035794, Example 32::US10683287, Example 32::US8637508, 32	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 26.0							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116255	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116255&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70356240	199996639							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531955	Cc1cnc(cn1)C(=O)Nc1ccc(F)c(n1)[C@]1(C)CO[C@](C)(C(N)=N1)C(F)(F)F	InChI=1S/C18H18F4N6O2/c1-9-6-25-11(7-24-9)14(29)27-12-5-4-10(19)13(26-12)16(2)8-30-17(3,15(23)28-16)18(20,21)22/h4-7H,8H2,1-3H3,(H2,23,28)(H,26,27,29)/t16-,17+/m0/s1	QEEWKGAHKUUMAX-DLBZAZTESA-N	116256	US10035794, Example 33::US10683287, Example 33::US8637508, 33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 130							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116256	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116256&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70356222	199996640							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531956	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C(F)(F)F)ccc1F	InChI=1S/C19H15ClF7N5O2/c1-16(7-34-17(2,15(28)32-16)19(25,26)27)13-10(21)3-4-11(30-13)31-14(33)12-9(20)5-8(6-29-12)18(22,23)24/h3-6H,7H2,1-2H3,(H2,28,32)(H,30,31,33)/t16-,17+/m0/s1	PSBBWFNMHDUTRH-DLBZAZTESA-N	116257	US10035794, Example 34::US10683287, Example 34::US8637508, 34	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3.00							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116257&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	BUH	6EQM	88602735	199996641							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531957	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cc(NC(=O)c2ncc(cc2Cl)C#N)ncc1F	InChI=1S/C19H15ClF4N6O2/c1-17(8-32-18(2,16(26)30-17)19(22,23)24)10-4-13(27-7-12(10)21)29-15(31)14-11(20)3-9(5-25)6-28-14/h3-4,6-7H,8H2,1-2H3,(H2,26,30)(H,27,29,31)/t17-,18+/m0/s1	RPVSVZJNXFHPNA-ZWKOTPCHSA-N	116258	US10035794, Example 35::US8637508, 35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 140							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116258	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116258&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70356241	199996642							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531958	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1cc(NC(=O)c2ncc(OC(F)F)cc2Cl)ncc1F	InChI=1S/C19H16ClF6N5O3/c1-17(7-33-18(2,15(27)31-17)19(24,25)26)9-4-12(28-6-11(9)21)30-14(32)13-10(20)3-8(5-29-13)34-16(22)23/h3-6,16H,7H2,1-2H3,(H2,27,31)(H,28,30,32)/t17-,18+/m0/s1	QONFJNGJOVKPCS-ZWKOTPCHSA-N	116259	US10035794, Example 36::US8637508, 36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 410							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116259	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116259&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			88602761	199996643							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531959	Cc1cc(cnc1C(=O)Nc1cc(c(F)cn1)[C@]1(C)COC(CF)(CF)C(N)=N1)C#N	InChI=1S/C20H19F3N6O2/c1-11-3-12(5-24)6-27-16(11)17(30)28-15-4-13(14(23)7-26-15)19(2)10-31-20(8-21,9-22)18(25)29-19/h3-4,6-7H,8-10H2,1-2H3,(H2,25,29)(H,26,28,30)/t19-/m0/s1	ZDOMSYMJUOFARG-IBGZPJMESA-N	116260	US10035794, Example 37::US10683287, Example 37::US8637508, 37	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 83.0							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116260	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116260&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70351283	199996644							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531960	Cc1cc(cnc1C(=O)Nc1ccc(F)c(n1)[C@@]1(COCC(N)=N1)C(F)F)C#N	InChI=1S/C18H15F3N6O2/c1-9-4-10(5-22)6-24-14(9)16(28)26-13-3-2-11(19)15(25-13)18(17(20)21)8-29-7-12(23)27-18/h2-4,6,17H,7-8H2,1H3,(H2,23,27)(H,25,26,28)/t18-/m0/s1	GIKOSRRRDYUWLE-SFHVURJKSA-N	116261	US10035794, Example 38::US10683287, Example 38::US8637508, 38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5.00							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116261	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116261&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70355171	199996645							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531961	Cc1cc(cnc1C(=O)Nc1ccc(F)c(n1)[C@]1(COCC(N)=N1)C(F)F)C#N	InChI=1S/C18H15F3N6O2/c1-9-4-10(5-22)6-24-14(9)16(28)26-13-3-2-11(19)15(25-13)18(17(20)21)8-29-7-12(23)27-18/h2-4,6,17H,7-8H2,1H3,(H2,23,27)(H,25,26,28)/t18-/m1/s1	GIKOSRRRDYUWLE-GOSISDBHSA-N	116262	US10035794, Example 39::US10683287, Example 39::US8637508, 39	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 290							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116262	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116262&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70356010	199996646							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531962	NC1=N[C@](COC1)(C(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C#N)ccc1F	InChI=1S/C17H12ClF3N6O2/c18-9-3-8(4-22)5-24-13(9)15(28)26-12-2-1-10(19)14(25-12)17(16(20)21)7-29-6-11(23)27-17/h1-3,5,16H,6-7H2,(H2,23,27)(H,25,26,28)/t17-/m0/s1	LVXIXHYWPFXDKS-KRWDZBQOSA-N	116263	US10035794, Example 40::US10683287, Example 40::US8637508, 40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12.0							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116263	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116263&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70356242	199996647							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531963	Cc1cnc(C(=O)Nc2ccc(F)c(n2)[C@]2(C)CO[C@](C)(C(N)=N2)C(F)(F)F)c(C)n1	InChI=1S/C19H20F4N6O2/c1-9-7-25-13(10(2)26-9)15(30)28-12-6-5-11(20)14(27-12)17(3)8-31-18(4,16(24)29-17)19(21,22)23/h5-7H,8H2,1-4H3,(H2,24,29)(H,27,28,30)/t17-,18+/m0/s1	NHQMQCNPITZLAA-ZWKOTPCHSA-N	116264	US10035794, Example 41::US10683287, Example 41::US8637508, 41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 161							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116264	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116264&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89951896	199996648							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531964	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(OCCCF)nc2N)ccc1F	InChI=1S/C20H22F5N7O3/c1-18(9-35-19(2,17(27)32-18)20(23,24)25)14-10(22)4-5-11(29-14)30-16(33)13-15(26)31-12(8-28-13)34-7-3-6-21/h4-5,8H,3,6-7,9H2,1-2H3,(H2,26,31)(H2,27,32)(H,29,30,33)/t18-,19+/m0/s1	JKHHBPZBBWGXHT-RBUKOAKNSA-N	116265	US10035794, Example 42::US10683287, Example 42::US8637508, 42	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 72.0							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116265	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116265&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70356059	199996649							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531965	COCCn1ccc2nc(C(=O)Nc3ccc(F)c(n3)[C@]3(C)CO[C@](C)(C(N)=N3)C(F)(F)F)c(N)nc12	InChI=1S/C22H24F4N8O3/c1-20(10-37-21(2,19(28)33-20)22(24,25)26)15-11(23)4-5-13(30-15)31-18(35)14-16(27)32-17-12(29-14)6-7-34(17)8-9-36-3/h4-7H,8-10H2,1-3H3,(H2,27,32)(H2,28,33)(H,30,31,35)/t20-,21+/m0/s1	MMFYRHYCSIOPDG-LEWJYISDSA-N	116266	US10035794, Example 43::US10683287, Example 43::US8637508, 43	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 370							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116266	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116266&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			70355173	199996650							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531966	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2ncc(nc2N)C(F)(F)F)ccc1F	InChI=1S/C18H16F7N7O2/c1-15(6-34-16(2,14(27)32-15)18(23,24)25)11-7(19)3-4-9(30-11)31-13(33)10-12(26)29-8(5-28-10)17(20,21)22/h3-5H,6H2,1-2H3,(H2,26,29)(H2,27,32)(H,30,31,33)/t15-,16+/m0/s1	HUQALVJHHCENTE-JKSUJKDBSA-N	116267	US10035794, Example 44::US10683287, Example 44::US8637508, 44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 30.0							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116267	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116267&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89951897	199996651							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
531967	C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2nc3ccn(CC(F)F)c3nc2N)ccc1F	InChI=1S/C21H20F6N8O2/c1-19(8-37-20(2,18(29)34-19)21(25,26)27)14-9(22)3-4-12(31-14)32-17(36)13-15(28)33-16-10(30-13)5-6-35(16)7-11(23)24/h3-6,11H,7-8H2,1-2H3,(H2,28,33)(H2,29,34)(H,31,32,36)/t19-,20+/m0/s1	WBCXJAZBPSKARJ-VQTJNVASSA-N	116268	US10035794, Example 45::US8637508, 45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3600							US Patent		10.7270/Q2RB76M3		aid1795587	US10035794	Badiger, S; Chebrolu, M; Hurth, K; Jacquier, S; Lueoend, RM; Machauer, R; Rueeger, H; Tintelnot-Blomley, M; Veenstra, SJ; Voegtle, M	7/31/2018	12/25/2018	Novartis AG	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=116268	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=116268&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			88602589	199996652							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532361	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC2)nc(NCC2CC2)n1	InChI=1S/C17H19F3N6/c18-17(19,20)13-3-1-2-12(23-13)14-24-15(21-8-10-4-5-10)26-16(25-14)22-9-11-6-7-11/h1-3,10-11H,4-9H2,(H2,21,22,24,25,26)	KNDBYTOOVAJFRN-UHFFFAOYSA-N	279854	US10028961, Compound 1::US10172864, Compound 1::US10946023, Compound 1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279854	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279854&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817069	378161425							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532365	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C19H23F3N6/c1-10(12-6-7-12)23-17-26-16(14-4-3-5-15(25-14)19(20,21)22)27-18(28-17)24-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,23,24,26,27,28)/t10-,11-/m1/s1	KRSKURCJOGAEOS-GHMZBOCLSA-N	279855	US10028961, Compound 2::US10172864, Compound 2::US10946023, Compound 2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279855	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279855&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	QWM	6VG0	117817076	378161426							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532370	CC(C)Nc1nc(NC(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C15H19F3N6/c1-8(2)19-13-22-12(23-14(24-13)20-9(3)4)10-6-5-7-11(21-10)15(16,17)18/h5-9H,1-4H3,(H2,19,20,22,23,24)	WDSFOQJWJKBMPM-UHFFFAOYSA-N	279856	US10028961, Compound 3::US10172864, Compound 3::US10946023, Compound 3	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279856	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279856&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817527	378161427							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532372	CC(C)(C)Nc1nc(NC(C)(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C17H23F3N6/c1-15(2,3)25-13-22-12(23-14(24-13)26-16(4,5)6)10-8-7-9-11(21-10)17(18,19)20/h7-9H,1-6H3,(H2,22,23,24,25,26)	GSAWFHLLQMRJAD-UHFFFAOYSA-N	279857	BDBM279926::US10028961, Compound 4::US10172864, Compound 76::US10946023, Compound 76	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279857	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279857&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466272	378161428							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532376	C[C@@H](Nc1nc(NCC(N)=O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C16H18F3N7O/c1-8(9-5-6-9)22-15-25-13(24-14(26-15)21-7-12(20)27)10-3-2-4-11(23-10)16(17,18)19/h2-4,8-9H,5-7H2,1H3,(H2,20,27)(H2,21,22,24,25,26)/t8-/m1/s1	YDQAYHKPLFMZEJ-MRVPVSSYSA-N	279858	US10028961, Compound 5::US10172864, Compound 5::US10946023, Compound 5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279858	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279858&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817530	378161429							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532377	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccccc1F)C1CC1	InChI=1S/C19H24FN5/c1-11(13-7-8-13)21-18-23-17(15-5-3-4-6-16(15)20)24-19(25-18)22-12(2)14-9-10-14/h3-6,11-14H,7-10H2,1-2H3,(H2,21,22,23,24,25)/t11-,12-/m1/s1	SBWSJSCKQBEYEK-VXGBXAGGSA-N	279859	US10028961, Compound 6::US10028961, Compound 77::US10172864, Compound 77::US10946023, Compound 77	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279859	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279859&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817088	378161430							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532379	FC(F)(F)c1cccc(n1)-c1nc(NCC2CCC2)nc(NCC2CCC2)n1	InChI=1S/C19H23F3N6/c20-19(21,22)15-9-3-8-14(25-15)16-26-17(23-10-12-4-1-5-12)28-18(27-16)24-11-13-6-2-7-13/h3,8-9,12-13H,1-2,4-7,10-11H2,(H2,23,24,26,27,28)	VPNNRJRDRDIMTN-UHFFFAOYSA-N	279860	US10028961, Compound 7::US10172864, Compound 7::US10946023, Compound 7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279860	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279860&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466271	378161431							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532384	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC2)nc(NC2CCC2)n1	InChI=1S/C17H19F3N6/c18-17(19,20)13-9-3-8-12(23-13)14-24-15(21-10-4-1-5-10)26-16(25-14)22-11-6-2-7-11/h3,8-11H,1-2,4-7H2,(H2,21,22,24,25,26)	PVIJXHIYMYVGOF-UHFFFAOYSA-N	279862	US10028961, Compound 9::US10172864, Compound 9::US10946023, Compound 9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279862	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279862&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466412	378161433							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532387	C[C@@H](Nc1nc(NCC(C)(C)O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C18H23F3N6O/c1-10(11-7-8-11)23-16-26-14(25-15(27-16)22-9-17(2,3)28)12-5-4-6-13(24-12)18(19,20)21/h4-6,10-11,28H,7-9H2,1-3H3,(H2,22,23,25,26,27)/t10-/m1/s1	BMMLVEOASUDOHV-SNVBAGLBSA-N	279863	US10028961, Compound 10::US10028961, Compound 79::US10172864, Compound 79::US10946023, Compound 79	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279863	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279863&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817095	378161434							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532390	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(O)c1)C1CC1	InChI=1S/C19H25N5O/c1-11(13-6-7-13)20-18-22-17(15-4-3-5-16(25)10-15)23-19(24-18)21-12(2)14-8-9-14/h3-5,10-14,25H,6-9H2,1-2H3,(H2,20,21,22,23,24)/t11-,12-/m1/s1	JCZPGZCYKZMOEK-VXGBXAGGSA-N	279864	US10028961, Compound 11::US10028961, Compound 80::US10172864, Compound 80::US10946023, Compound 80	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279864	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279864&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799184	378161435							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532394	CC(O)CNc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C17H21F3N6O/c1-9(27)8-21-15-24-14(12-4-3-5-13(23-12)17(18,19)20)25-16(26-15)22-10(2)11-6-7-11/h3-5,9-11,27H,6-8H2,1-2H3,(H2,21,22,24,25,26)/t9?,10-/m1/s1	YADRVMCMMMHOSZ-QVDQXJPCSA-N	279865	US10028961, Compound 12::US10028961, Compound 81::US10172864, Compound 81::US10946023, Compound 81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279865	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279865&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817110	378161436							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532397	CC(C)C(C)Nc1nc(NC(C)C(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H27F3N6/c1-10(2)12(5)23-17-26-16(27-18(28-17)24-13(6)11(3)4)14-8-7-9-15(25-14)19(20,21)22/h7-13H,1-6H3,(H2,23,24,26,27,28)	OLELDTDOYATLQM-UHFFFAOYSA-N	279866	US10028961, Compound 13::US10172864, Compound 13::US10946023, Compound 13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279866	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279866&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466273	378161437							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532400	CC(O)CNc1nc(NCC(C)O)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C15H19F3N6O2/c1-8(25)6-19-13-22-12(23-14(24-13)20-7-9(2)26)10-4-3-5-11(21-10)15(16,17)18/h3-5,8-9,25-26H,6-7H2,1-2H3,(H2,19,20,22,23,24)	QYMUDBQWLSGBAS-UHFFFAOYSA-N	279867	US10028961, Compound 14::US10172864, Compound 14::US10946023, Compound 14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279867	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279867&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817085	378161438							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532403	C[C@@H](Nc1nc(NCC(C)=O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C17H19F3N6O/c1-9(27)8-21-15-24-14(12-4-3-5-13(23-12)17(18,19)20)25-16(26-15)22-10(2)11-6-7-11/h3-5,10-11H,6-8H2,1-2H3,(H2,21,22,24,25,26)/t10-/m1/s1	GZYMCQBNCUYDKE-SNVBAGLBSA-N	279868	US10028961, Compound 15::US10172864, Compound 15::US10946023, Compound 15	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279868	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279868&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817099	378161439							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532405	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(CO)c1)C1CC1	InChI=1S/C20H27N5O/c1-12(15-6-7-15)21-19-23-18(17-5-3-4-14(10-17)11-26)24-20(25-19)22-13(2)16-8-9-16/h3-5,10,12-13,15-16,26H,6-9,11H2,1-2H3,(H2,21,22,23,24,25)/t12-,13-/m1/s1	DXDMRKXHWQBBBA-CHWSQXEVSA-N	279869	US10028961, Compound 16::US10028961, Compound 82::US10172864, Compound 82::US10946023, Compound 82	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279869	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279869&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817092	378161440							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532408	CC(C)[C@H](C)Nc1nc(N[C@@H](C)C(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H27F3N6/c1-10(2)12(5)23-17-26-16(27-18(28-17)24-13(6)11(3)4)14-8-7-9-15(25-14)19(20,21)22/h7-13H,1-6H3,(H2,23,24,26,27,28)/t12-,13-/m0/s1	OLELDTDOYATLQM-STQMWFEESA-N	279870	US10028961, Compound 17::US10172864, Compound 17::US10946023, Compound 17	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279870	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279870&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817087	378161441							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532411	CC(C)[C@@H](C)Nc1nc(N[C@H](C)C(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H27F3N6/c1-10(2)12(5)23-17-26-16(27-18(28-17)24-13(6)11(3)4)14-8-7-9-15(25-14)19(20,21)22/h7-13H,1-6H3,(H2,23,24,26,27,28)/t12-,13-/m1/s1	OLELDTDOYATLQM-CHWSQXEVSA-N	279871	US10028961, Compound 18::US10172864, Compound 18::US10946023, Compound 18	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279871	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279871&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817080	378161442							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532414	C[C@@H](Nc1nc(N[C@H](C)C2CCC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CCC1	InChI=1S/C21H27F3N6/c1-12(14-6-3-7-14)25-19-28-18(16-10-5-11-17(27-16)21(22,23)24)29-20(30-19)26-13(2)15-8-4-9-15/h5,10-15H,3-4,6-9H2,1-2H3,(H2,25,26,28,29,30)/t12-,13-/m1/s1	HTFFUPGDRXDEIP-CHWSQXEVSA-N	279872	US10028961, Compound 19::US10172864, Compound 19::US10946023, Compound 19	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279872	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279872&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817233	378161443							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532417	C[C@@H](Nc1nc(N[C@@H](C)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C22H23F3N6/c1-13(15-7-4-3-5-8-15)26-20-29-19(17-9-6-10-18(28-17)22(23,24)25)30-21(31-20)27-14(2)16-11-12-16/h3-10,13-14,16H,11-12H2,1-2H3,(H2,26,27,29,30,31)/t13-,14+/m0/s1	YJZZCQZAKQBAMU-UONOGXRCSA-N	279873	US10028961, Compound 20::US10172864, Compound 20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279873	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279873&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817082	378161444							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532418	C[C@@H](Nc1nc(N[C@@H](C)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C22H23F3N6/c1-13(15-7-4-3-5-8-15)26-20-29-19(17-9-6-10-18(28-17)22(23,24)25)30-21(31-20)27-14(2)16-11-12-16/h3-10,13-14,16H,11-12H2,1-2H3,(H2,26,27,29,30,31)/t13-,14+/m0/s1	YJZZCQZAKQBAMU-UONOGXRCSA-N	279873	US10028961, Compound 20::US10172864, Compound 20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279873	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279873&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817082	378161444							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532421	C[C@@H](Nc1nc(NCc2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C21H21F3N6/c1-13(15-10-11-15)26-20-29-18(16-8-5-9-17(27-16)21(22,23)24)28-19(30-20)25-12-14-6-3-2-4-7-14/h2-9,13,15H,10-12H2,1H3,(H2,25,26,28,29,30)/t13-/m1/s1	IUYXTIDKXVUWDD-CYBMUJFWSA-N	279874	US10028961, Compound 21::US10172864, Compound 21::US10946023, Compound 21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279874	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279874&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817101	378161445							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532424	C[C@@H](Nc1nc(N[C@H](C)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C22H23F3N6/c1-13(15-7-4-3-5-8-15)26-20-29-19(17-9-6-10-18(28-17)22(23,24)25)30-21(31-20)27-14(2)16-11-12-16/h3-10,13-14,16H,11-12H2,1-2H3,(H2,26,27,29,30,31)/t13-,14-/m1/s1	YJZZCQZAKQBAMU-ZIAGYGMSSA-N	279875	US10028961, Compound 22::US10172864, Compound 22::US10946023, Compound 22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279875	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279875&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817118	378161446							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532427	C[C@@H](Nc1nc(N[C@@H]2C[C@H]2c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C23H23F3N6/c1-13(14-10-11-14)27-21-30-20(17-8-5-9-19(28-17)23(24,25)26)31-22(32-21)29-18-12-16(18)15-6-3-2-4-7-15/h2-9,13-14,16,18H,10-12H2,1H3,(H2,27,29,30,31,32)/t13-,16+,18-/m1/s1	MPVKJRGUFDYPQR-RPVQJOFSSA-N	279876	US10028961, Compound 23::US10172864, Compound 23::US10946023, Compound 23	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279876	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279876&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817033	378161447							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532429	C[C@@H](Nc1nc(NCc2ccccn2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H20F3N7/c1-12(13-8-9-13)26-19-29-17(15-6-4-7-16(27-15)20(21,22)23)28-18(30-19)25-11-14-5-2-3-10-24-14/h2-7,10,12-13H,8-9,11H2,1H3,(H2,25,26,28,29,30)/t12-/m1/s1	YMKOTGDUPIYQMS-GFCCVEGCSA-N	279877	US10028961, Compound 24::US10028961, Compound 83::US10172864, Compound 83::US10946023, Compound 83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279877	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279877&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817120	378161448							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532431	C[C@@H](Nc1nc(NC(C)c2ccccn2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C21H22F3N7/c1-12(14-9-10-14)26-19-29-18(16-7-5-8-17(28-16)21(22,23)24)30-20(31-19)27-13(2)15-6-3-4-11-25-15/h3-8,11-14H,9-10H2,1-2H3,(H2,26,27,29,30,31)/t12-,13?/m1/s1	PVBOMIYGGWSXIY-PZORYLMUSA-N	279878	US10028961, Compound 25::US10028961, Compound 84::US10172864, Compound 84::US10946023, Compound 84	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279878	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279878&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817107	378161449							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532433	C[C@@H](Nc1nc(N[C@@H](C)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)c1ccccc1	InChI=1S/C25H23F3N6/c1-16(18-10-5-3-6-11-18)29-23-32-22(20-14-9-15-21(31-20)25(26,27)28)33-24(34-23)30-17(2)19-12-7-4-8-13-19/h3-17H,1-2H3,(H2,29,30,32,33,34)/t16-,17+	LBAZIFOJZOIFON-CALCHBBNSA-N	279879	US10028961, Compound 26::US10172864, Compound 26::US10946023, Compound 26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279879	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279879&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817147	378161450							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532436	C[C@@H](Nc1nc(NC(C)c2cccc(c2)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C23H22F6N6/c1-12(14-9-10-14)30-20-33-19(17-7-4-8-18(32-17)23(27,28)29)34-21(35-20)31-13(2)15-5-3-6-16(11-15)22(24,25)26/h3-8,11-14H,9-10H2,1-2H3,(H2,30,31,33,34,35)/t12-,13?/m1/s1	OUNUKDITMWXSMU-PZORYLMUSA-N	279880	US10028961, Compound 27::US10172864, Compound 27::US10946023, Compound 27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279880	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279880&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817140	378161451							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532438	C[C@@H](Nc1nc(NC(C)c2cccc(F)c2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C22H22F4N6/c1-12(14-9-10-14)27-20-30-19(17-7-4-8-18(29-17)22(24,25)26)31-21(32-20)28-13(2)15-5-3-6-16(23)11-15/h3-8,11-14H,9-10H2,1-2H3,(H2,27,28,30,31,32)/t12-,13?/m1/s1	JYVZJECTMOHVFX-PZORYLMUSA-N	279881	US10028961, Compound 28::US10172864, Compound 28::US10946023, Compound 28	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279881	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279881&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817145	378161452							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532439	C[C@@H](Nc1nc(NC(C)c2cccc(F)c2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C22H22F4N6/c1-12(14-9-10-14)27-20-30-19(17-7-4-8-18(29-17)22(24,25)26)31-21(32-20)28-13(2)15-5-3-6-16(23)11-15/h3-8,11-14H,9-10H2,1-2H3,(H2,27,28,30,31,32)/t12-,13?/m1/s1	JYVZJECTMOHVFX-PZORYLMUSA-N	279881	US10028961, Compound 28::US10172864, Compound 28::US10946023, Compound 28	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279881	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279881&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817145	378161452							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532442	C[C@@H](Nc1nc(NC(=O)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C21H19F3N6O/c1-12(13-10-11-13)25-19-27-17(15-8-5-9-16(26-15)21(22,23)24)28-20(30-19)29-18(31)14-6-3-2-4-7-14/h2-9,12-13H,10-11H2,1H3,(H2,25,27,28,29,30,31)/t12-/m1/s1	IQRLKQDCDTZTJN-GFCCVEGCSA-N	279882	US10028961, Compound 29::US10172864, Compound 29::US10946023, Compound 29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279882	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279882&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817153	378161453							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532444	C[C@@H](Nc1nc(NC2(CC2)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C23H23F3N6/c1-14(15-10-11-15)27-20-29-19(17-8-5-9-18(28-17)23(24,25)26)30-21(31-20)32-22(12-13-22)16-6-3-2-4-7-16/h2-9,14-15H,10-13H2,1H3,(H2,27,29,30,31,32)/t14-/m1/s1	MMQKYUIBTNHALE-CQSZACIVSA-N	279883	US10028961, Compound 30::US10028961, Compound 85::US10172864, Compound 85::US10946023, Compound 85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279883	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279883&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466563	378161454							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532447	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	JWMKUJAOIPXYIG-UHFFFAOYSA-N	279884	US10028961, Compound 31::US10172864, Compound 31::US10946023, Compound 31	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279884	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279884&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86580656	378161455							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532451	COc1ccc(F)c(c1)-c1nc(NC(C)C)nc(NC(C)(C)C#N)n1	InChI=1S/C17H21FN6O/c1-10(2)20-15-21-14(12-8-11(25-5)6-7-13(12)18)22-16(23-15)24-17(3,4)9-19/h6-8,10H,1-5H3,(H2,20,21,22,23,24)	JTBPNQFDWIZOKU-UHFFFAOYSA-N	279885	US10028961, Compound 32::US10172864, Compound 32::US10946023, Compound 32	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279885	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279885&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799404	378161456							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532453	C[C@H](Nc1nc(N[C@@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C19H23F3N6/c1-10(12-6-7-12)23-17-26-16(14-4-3-5-15(25-14)19(20,21)22)27-18(28-17)24-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,23,24,26,27,28)/t10-,11-/m0/s1	KRSKURCJOGAEOS-QWRGUYRKSA-N	279886	US10028961, Compound 33::US10172864, Compound 33::US10946023, Compound 33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279886	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279886&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817234	378161457							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532456	C[C@@H](Nc1nc(N[C@@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C19H23F3N6/c1-10(12-6-7-12)23-17-26-16(14-4-3-5-15(25-14)19(20,21)22)27-18(28-17)24-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,23,24,26,27,28)/t10-,11+	KRSKURCJOGAEOS-PHIMTYICSA-N	279887	US10028961, Compound 34::US10172864, Compound 34::US10946023, Compound 34	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279887	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279887&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817526	378161458							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532459	CC(C)Nc1nc(NC(C)(C)C#N)nc(n1)-c1cc(O)ccc1F	InChI=1S/C16H19FN6O/c1-9(2)19-14-20-13(11-7-10(24)5-6-12(11)17)21-15(22-14)23-16(3,4)8-18/h5-7,9,24H,1-4H3,(H2,19,20,21,22,23)	ZKCSHTWHAVTEDI-UHFFFAOYSA-N	279888	US10028961, Compound 35::US10172864, Compound 35::US10946023, Compound 35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279888	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279888&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817394	378161459							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532461	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3CC3C2)nc(NC2CC3CC3C2)n1	InChI=1S/C21H23F3N6/c22-21(23,24)17-3-1-2-16(27-17)18-28-19(25-14-6-10-4-11(10)7-14)30-20(29-18)26-15-8-12-5-13(12)9-15/h1-3,10-15H,4-9H2,(H2,25,26,28,29,30)	DLSICRMIGDILCI-UHFFFAOYSA-N	279889	US10028961, Compound 36::US10172864, Compound 36::US10946023, Compound 36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279889	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279889&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466413	378161460							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532462	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3CC3C2)nc(NC2CC3CC3C2)n1	InChI=1S/C21H23F3N6/c22-21(23,24)17-3-1-2-16(27-17)18-28-19(25-14-6-10-4-11(10)7-14)30-20(29-18)26-15-8-12-5-13(12)9-15/h1-3,10-15H,4-9H2,(H2,25,26,28,29,30)	DLSICRMIGDILCI-UHFFFAOYSA-N	279889	US10028961, Compound 36::US10172864, Compound 36::US10946023, Compound 36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279889	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279889&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466413	378161460							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532464	C[C@@H](Nc1nc(NC(C)(C)C#N)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C18H20F3N7/c1-10(11-7-8-11)23-15-25-14(26-16(27-15)28-17(2,3)9-22)12-5-4-6-13(24-12)18(19,20)21/h4-6,10-11H,7-8H2,1-3H3,(H2,23,25,26,27,28)/t10-/m1/s1	QDXATNXZLOTYRV-SNVBAGLBSA-N	279890	US10028961, Compound 37::US10028961, Compound 87::US10172864, Compound 87::US10946023, Compound 87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279890	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279890&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817466	378161461							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532466	C[C@@H](Nc1nc(NC2CCOC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C18H21F3N6O/c1-10(11-5-6-11)22-16-25-15(13-3-2-4-14(24-13)18(19,20)21)26-17(27-16)23-12-7-8-28-9-12/h2-4,10-12H,5-9H2,1H3,(H2,22,23,25,26,27)/t10-,12?/m1/s1	RWSYXAQFFAQAEC-RWANSRKNSA-N	279891	US10028961, Compound 38::US10172864, Compound 38::US10946023, Compound 38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279891	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279891&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817537	378161462							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532468	CCCC(C)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H25F3N6/c1-4-6-11(2)23-17-26-16(14-7-5-8-15(25-14)19(20,21)22)27-18(28-17)24-12(3)13-9-10-13/h5,7-8,11-13H,4,6,9-10H2,1-3H3,(H2,23,24,26,27,28)/t11?,12-/m1/s1	PETSAMLQOBIHSS-PIJUOVFKSA-N	279892	US10028961, Compound 39::US10172864, Compound 39::US10946023, Compound 39	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279892	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279892&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799007	378161463							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532471	CC(Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C17H18F3N7/c1-9(8-21)22-15-25-14(12-4-3-5-13(24-12)17(18,19)20)26-16(27-15)23-10(2)11-6-7-11/h3-5,9-11H,6-7H2,1-2H3,(H2,22,23,25,26,27)/t9?,10-/m1/s1	YBMLCUNTUFVOKD-QVDQXJPCSA-N	279893	US10028961, Compound 40::US10172864, Compound 40::US10946023, Compound 40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279893	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279893&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817588	378161464							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532473	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H23F7N6/c22-19(23)8-4-12(5-9-19)29-17-32-16(14-2-1-3-15(31-14)21(26,27)28)33-18(34-17)30-13-6-10-20(24,25)11-7-13/h1-3,12-13H,4-11H2,(H2,29,30,32,33,34)	LYMZYGUSADHRMY-UHFFFAOYSA-N	279894	US10028961, Compound 41::US10172864, Compound 41::US10946023, Compound 41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279894	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279894&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466415	378161465							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532475	C[C@@H](Nc1nc(N[C@H]2CCCC[C@@H]2O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H25F3N6O/c1-11(12-9-10-12)24-18-27-17(14-6-4-8-16(25-14)20(21,22)23)28-19(29-18)26-13-5-2-3-7-15(13)30/h4,6,8,11-13,15,30H,2-3,5,7,9-10H2,1H3,(H2,24,26,27,28,29)/t11-,13+,15+/m1/s1	DNYYBCNJEMMGNA-ZLDLUXBVSA-N	279895	US10028961, Compound 42::US10172864, Compound 42::US10946023, Compound 42	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279895	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279895&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817502	378161466							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532477	C[C@@H](Nc1nc(N[C@H]2CCC[C@H]2O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C19H23F3N6O/c1-10(11-8-9-11)23-17-26-16(13-5-3-7-15(24-13)19(20,21)22)27-18(28-17)25-12-4-2-6-14(12)29/h3,5,7,10-12,14,29H,2,4,6,8-9H2,1H3,(H2,23,25,26,27,28)/t10-,12+,14-/m1/s1	UHUHOBBXPQIHRY-SCDSUCTJSA-N	279896	US10028961, Compound 43::US10172864, Compound 43::US10946023, Compound 43	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279896	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279896&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			122440835	378161467							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532479	COCC(C)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C18H23F3N6O/c1-10(9-28-3)22-16-25-15(13-5-4-6-14(24-13)18(19,20)21)26-17(27-16)23-11(2)12-7-8-12/h4-6,10-12H,7-9H2,1-3H3,(H2,22,23,25,26,27)/t10?,11-/m1/s1	LUBVUPNBKHPQTK-RRKGBCIJSA-N	279897	US10028961, Compound 44::US10172864, Compound 44::US10946023, Compound 44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279897	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279897&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817089	378161468							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532481	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(Cl)n1)C1CC1	InChI=1S/C18H23ClN6/c1-10(12-6-7-12)20-17-23-16(14-4-3-5-15(19)22-14)24-18(25-17)21-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,20,21,23,24,25)/t10-,11-/m1/s1	GTMXNXATSGQGCH-GHMZBOCLSA-N	279898	US10028961, Compound 45::US10172864, Compound 45::US10946023, Compound 45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279898	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279898&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799064	378161469							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532483	CCN(CC)c1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(Cl)n1	InChI=1S/C17H23ClN6/c1-4-24(5-2)17-22-15(13-7-6-8-14(18)20-13)21-16(23-17)19-11(3)12-9-10-12/h6-8,11-12H,4-5,9-10H2,1-3H3,(H,19,21,22,23)/t11-/m1/s1	XYQKRMAHYVIZRA-LLVKDONJSA-N	279899	US10028961, Compound 46::US10028961, Compound 88::US10172864, Compound 88::US10946023, Compound 88	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279899	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279899&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817084	378161470							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532485	C[C@@H](Nc1nc(N[C@H](C)C(O)=O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C17H19F3N6O2/c1-8(10-6-7-10)21-15-24-13(25-16(26-15)22-9(2)14(27)28)11-4-3-5-12(23-11)17(18,19)20/h3-5,8-10H,6-7H2,1-2H3,(H,27,28)(H2,21,22,24,25,26)/t8-,9-/m1/s1	OVEVKHHIEURDIP-RKDXNWHRSA-N	279900	US10028961, Compound 47::US10172864, Compound 47::US10946023, Compound 47	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279900	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279900&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817090	378161471							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532486	C[C@@H](Nc1nc(N[C@H](C)C(=O)N(C)C)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C19H24F3N7O/c1-10(12-8-9-12)23-17-26-15(13-6-5-7-14(25-13)19(20,21)22)27-18(28-17)24-11(2)16(30)29(3)4/h5-7,10-12H,8-9H2,1-4H3,(H2,23,24,26,27,28)/t10-,11-/m1/s1	GFSAAPLIWHCOTJ-GHMZBOCLSA-N	279901	US10028961, Compound 48::US10172864, Compound 48::US10946023, Compound 48	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279901	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279901&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817102	378161472							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532487	CC(C)(CO)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H20F5N7O/c1-18(2,10-33)32-17-30-15(12-5-4-6-13(28-12)20(23,24)25)29-16(31-17)27-11-7-8-26-14(9-11)19(3,21)22/h4-9,33H,10H2,1-3H3,(H2,26,27,29,30,31,32)	VPNOHMBISYXVRN-UHFFFAOYSA-N	279902	US10028961, Compound 49::US10172864, Compound 49::US10946023, Compound 49	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279902	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279902&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817105	378161473							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532489	C[C@@H](Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H23F5N6/c1-11(12-5-6-12)26-17-29-16(14-3-2-4-15(28-14)20(23,24)25)30-18(31-17)27-13-7-9-19(21,22)10-8-13/h2-4,11-13H,5-10H2,1H3,(H2,26,27,29,30,31)/t11-/m1/s1	VHWMBKQPXXLOFJ-LLVKDONJSA-N	279903	US10028961, Compound 50::US10172864, Compound 50	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279903	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279903&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817596	378161474							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532490	C[C@@H](Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H23F5N6/c1-11(12-5-6-12)26-17-29-16(14-3-2-4-15(28-14)20(23,24)25)30-18(31-17)27-13-7-9-19(21,22)10-8-13/h2-4,11-13H,5-10H2,1H3,(H2,26,27,29,30,31)/t11-/m1/s1	VHWMBKQPXXLOFJ-LLVKDONJSA-N	279903	US10028961, Compound 50::US10172864, Compound 50	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279903	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279903&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817596	378161474							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532492	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)N1CCC1)C1CC1	InChI=1S/C21H29N7/c1-13(15-7-8-15)22-20-25-19(26-21(27-20)23-14(2)16-9-10-16)17-5-3-6-18(24-17)28-11-4-12-28/h3,5-6,13-16H,4,7-12H2,1-2H3,(H2,22,23,25,26,27)/t13-,14-/m1/s1	HSMKSLUXGRHQJU-ZIAGYGMSSA-N	279904	US10028961, Compound 51::US10028961, Compound 89::US10172864, Compound 89::US10946023, Compound 89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279904	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279904&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817093	378161475							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532494	FC(F)(F)c1cccc(n1)-c1nc(NC2CCOC2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H19F5N6O/c19-17(20)6-4-10(8-17)24-15-27-14(12-2-1-3-13(26-12)18(21,22)23)28-16(29-15)25-11-5-7-30-9-11/h1-3,10-11H,4-9H2,(H2,24,25,27,28,29)	HBTPVNIAECEEFE-UHFFFAOYSA-N	279905	US10028961, Compound 52::US10172864, Compound 52::US10946023, Compound 52	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279905	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279905&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466560	378161476							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532496	CC(C)(C)OC(=O)N1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C23H28F5N7O2/c1-21(2,3)37-20(36)35-10-8-14(12-35)30-19-33-17(15-5-4-6-16(31-15)23(26,27)28)32-18(34-19)29-13-7-9-22(24,25)11-13/h4-6,13-14H,7-12H2,1-3H3,(H2,29,30,32,33,34)	MDGYQOGSIDPTTI-UHFFFAOYSA-N	279906	US10028961, Compound 53::US10028961, Compound 90::US10172864, Compound 90::US10946023, Compound 90	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279906	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279906&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466417	378161477							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532498	FC(F)(F)c1cccc(n1)-c1nc(NC2CCNC2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H20F5N7/c19-17(20)6-4-10(8-17)25-15-28-14(12-2-1-3-13(27-12)18(21,22)23)29-16(30-15)26-11-5-7-24-9-11/h1-3,10-11,24H,4-9H2,(H2,25,26,28,29,30)	IXFTZPSJWXQNPG-UHFFFAOYSA-N	279907	US10028961, Compound 54::US10028961, Compound 91::US10172864, Compound 91::US10946023, Compound 91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279907	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279907&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466416	378161478							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532500	CC(=O)N1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H22F5N7O/c1-11(33)32-8-6-13(10-32)27-18-30-16(14-3-2-4-15(28-14)20(23,24)25)29-17(31-18)26-12-5-7-19(21,22)9-12/h2-4,12-13H,5-10H2,1H3,(H2,26,27,29,30,31)	YVNPRQSYAIXEEB-UHFFFAOYSA-N	279908	US10028961, Compound 55::US10172864, Compound 55::US10946023, Compound 55	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279908	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279908&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817503	378161479							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532502	CS(=O)(=O)N1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H22F5N7O2S/c1-34(32,33)31-8-6-12(10-31)26-17-29-15(13-3-2-4-14(27-13)19(22,23)24)28-16(30-17)25-11-5-7-18(20,21)9-11/h2-4,11-12H,5-10H2,1H3,(H2,25,26,28,29,30)	CCAAECSCQISUPX-UHFFFAOYSA-N	279909	US10028961, Compound 56::US10172864, Compound 56::US10946023, Compound 56	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279909	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279909&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817533	378161480							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532504	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccnc1)C1CC1	InChI=1S/C18H24N6/c1-11(13-5-6-13)20-17-22-16(15-4-3-9-19-10-15)23-18(24-17)21-12(2)14-7-8-14/h3-4,9-14H,5-8H2,1-2H3,(H2,20,21,22,23,24)/t11-,12-/m1/s1	GWYWLYIKFLDUMQ-VXGBXAGGSA-N	279910	US10028961, Compound 57::US10028961, Compound 92::US10172864, Compound 92::US10946023, Compound 92	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279910	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279910&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466562	378161481							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532506	C[C@@H](Nc1nc(NC2CC3(C2)CC(F)(F)C3)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C21H23F5N6/c1-11(12-5-6-12)27-17-30-16(14-3-2-4-15(29-14)21(24,25)26)31-18(32-17)28-13-7-19(8-13)9-20(22,23)10-19/h2-4,11-13H,5-10H2,1H3,(H2,27,28,30,31,32)/t11-/m1/s1	RMLKOVRFURMNDJ-LLVKDONJSA-N	279911	US10028961, Compound 58::US10172864, Compound 58::US10946023, Compound 58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279911	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279911&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817535	378161482							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532508	COC(=O)N1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H22F5N7O2/c1-34-18(33)32-8-6-12(10-32)27-17-30-15(13-3-2-4-14(28-13)20(23,24)25)29-16(31-17)26-11-5-7-19(21,22)9-11/h2-4,11-12H,5-10H2,1H3,(H2,26,27,29,30,31)	HBUVPQWRGSFFAM-UHFFFAOYSA-N	279912	US10028961, Compound 59::US10172864, Compound 59::US10946023, Compound 59	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279912	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279912&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799339	378161483							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532509	C[C@@H](Nc1nc(NC2Cc3ccccc3C2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C23H23F3N6/c1-13(14-9-10-14)27-21-30-20(18-7-4-8-19(29-18)23(24,25)26)31-22(32-21)28-17-11-15-5-2-3-6-16(15)12-17/h2-8,13-14,17H,9-12H2,1H3,(H2,27,28,30,31,32)/t13-/m1/s1	QNCFEEZALZKPFF-CYBMUJFWSA-N	279913	US10028961, Compound 60::US10172864, Compound 60::US10946023, Compound 60	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279913	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279913&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466561	378161484							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532510	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccccn1)C1CC1	InChI=1S/C18H24N6/c1-11(13-6-7-13)20-17-22-16(15-5-3-4-10-19-15)23-18(24-17)21-12(2)14-8-9-14/h3-5,10-14H,6-9H2,1-2H3,(H2,20,21,22,23,24)/t11-,12-/m1/s1	LQIAKXUZNSTYRL-VXGBXAGGSA-N	279914	US10028961, Compound 61::US10028961, Compound 93::US10172864, Compound 93::US10946023, Compound 93	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279914	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279914&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817412	378161485							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532512	COCC(COC)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H25F3N6O2/c1-11(12-7-8-12)23-17-26-16(14-5-4-6-15(25-14)19(20,21)22)27-18(28-17)24-13(9-29-2)10-30-3/h4-6,11-13H,7-10H2,1-3H3,(H2,23,24,26,27,28)/t11-/m1/s1	UALNWZBGYZUTGB-LLVKDONJSA-N	279915	US10028961, Compound 63::US10172864, Compound 63::US10946023, Compound 63	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279915	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279915&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817501	378161486							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532513	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(Cl)c1)C1CC1	InChI=1S/C19H24ClN5/c1-11(13-6-7-13)21-18-23-17(15-4-3-5-16(20)10-15)24-19(25-18)22-12(2)14-8-9-14/h3-5,10-14H,6-9H2,1-2H3,(H2,21,22,23,24,25)/t11-,12-/m1/s1	MUAWGTSYRLJHHM-VXGBXAGGSA-N	279916	US10028961, Compound 64::US10172864, Compound 64::US10946023, Compound 64	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279916	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279916&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817534	378161487							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532514	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccccc1Cl)C1CC1	InChI=1S/C19H24ClN5/c1-11(13-7-8-13)21-18-23-17(15-5-3-4-6-16(15)20)24-19(25-18)22-12(2)14-9-10-14/h3-6,11-14H,7-10H2,1-2H3,(H2,21,22,23,24,25)/t11-,12-/m1/s1	BFRTUOCWCLMKIN-VXGBXAGGSA-N	279917	US10028961, Compound 66::US10028961, Compound 94::US10172864, Compound 94::US10946023, Compound 94	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279917	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279917&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817340	378161488							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532515	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccncc1)C1CC1	InChI=1S/C18H24N6/c1-11(13-3-4-13)20-17-22-16(15-7-9-19-10-8-15)23-18(24-17)21-12(2)14-5-6-14/h7-14H,3-6H2,1-2H3,(H2,20,21,22,23,24)/t11-,12-/m1/s1	JZOVQRSRIPIGKZ-VXGBXAGGSA-N	279918	US10028961, Compound 67::US10028961, Compound 95::US10172864, Compound 95::US10946023, Compound 95	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279918	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279918&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817342	378161489							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532527	CC(C)(C)Nc1nc(NC(C)(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C17H23F3N6/c1-15(2,3)25-13-22-12(23-14(24-13)26-16(4,5)6)10-8-7-9-11(21-10)17(18,19)20/h7-9H,1-6H3,(H2,22,23,24,25,26)	GSAWFHLLQMRJAD-UHFFFAOYSA-N	279857	BDBM279926::US10028961, Compound 4::US10172864, Compound 76::US10946023, Compound 76	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279857	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279857&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466272	378161428							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532531	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccccc1F)C1CC1	InChI=1S/C19H24FN5/c1-11(13-7-8-13)21-18-23-17(15-5-3-4-6-16(15)20)24-19(25-18)22-12(2)14-9-10-14/h3-6,11-14H,7-10H2,1-2H3,(H2,21,22,23,24,25)/t11-,12-/m1/s1	SBWSJSCKQBEYEK-VXGBXAGGSA-N	279859	US10028961, Compound 6::US10028961, Compound 77::US10172864, Compound 77::US10946023, Compound 77	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279859	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279859&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817088	378161430							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532535	C[C@@H](Nc1nc(NCC(C)(C)O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C18H23F3N6O/c1-10(11-7-8-11)23-16-26-14(25-15(27-16)22-9-17(2,3)28)12-5-4-6-13(24-12)18(19,20)21/h4-6,10-11,28H,7-9H2,1-3H3,(H2,22,23,25,26,27)/t10-/m1/s1	BMMLVEOASUDOHV-SNVBAGLBSA-N	279863	US10028961, Compound 10::US10028961, Compound 79::US10172864, Compound 79::US10946023, Compound 79	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279863	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279863&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817095	378161434							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532538	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(O)c1)C1CC1	InChI=1S/C19H25N5O/c1-11(13-6-7-13)20-18-22-17(15-4-3-5-16(25)10-15)23-19(24-18)21-12(2)14-8-9-14/h3-5,10-14,25H,6-9H2,1-2H3,(H2,20,21,22,23,24)/t11-,12-/m1/s1	JCZPGZCYKZMOEK-VXGBXAGGSA-N	279864	US10028961, Compound 11::US10028961, Compound 80::US10172864, Compound 80::US10946023, Compound 80	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279864	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279864&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799184	378161435							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532542	CC(O)CNc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C17H21F3N6O/c1-9(27)8-21-15-24-14(12-4-3-5-13(23-12)17(18,19)20)25-16(26-15)22-10(2)11-6-7-11/h3-5,9-11,27H,6-8H2,1-2H3,(H2,21,22,24,25,26)/t9?,10-/m1/s1	YADRVMCMMMHOSZ-QVDQXJPCSA-N	279865	US10028961, Compound 12::US10028961, Compound 81::US10172864, Compound 81::US10946023, Compound 81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279865	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279865&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817110	378161436							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532545	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(CO)c1)C1CC1	InChI=1S/C20H27N5O/c1-12(15-6-7-15)21-19-23-18(17-5-3-4-14(10-17)11-26)24-20(25-19)22-13(2)16-8-9-16/h3-5,10,12-13,15-16,26H,6-9,11H2,1-2H3,(H2,21,22,23,24,25)/t12-,13-/m1/s1	DXDMRKXHWQBBBA-CHWSQXEVSA-N	279869	US10028961, Compound 16::US10028961, Compound 82::US10172864, Compound 82::US10946023, Compound 82	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279869	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279869&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817092	378161440							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532548	C[C@@H](Nc1nc(NCc2ccccn2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H20F3N7/c1-12(13-8-9-13)26-19-29-17(15-6-4-7-16(27-15)20(21,22)23)28-18(30-19)25-11-14-5-2-3-10-24-14/h2-7,10,12-13H,8-9,11H2,1H3,(H2,25,26,28,29,30)/t12-/m1/s1	YMKOTGDUPIYQMS-GFCCVEGCSA-N	279877	US10028961, Compound 24::US10028961, Compound 83::US10172864, Compound 83::US10946023, Compound 83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279877	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279877&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817120	378161448							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532550	C[C@@H](Nc1nc(NC(C)c2ccccn2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C21H22F3N7/c1-12(14-9-10-14)26-19-29-18(16-7-5-8-17(28-16)21(22,23)24)30-20(31-19)27-13(2)15-6-3-4-11-25-15/h3-8,11-14H,9-10H2,1-2H3,(H2,26,27,29,30,31)/t12-,13?/m1/s1	PVBOMIYGGWSXIY-PZORYLMUSA-N	279878	US10028961, Compound 25::US10028961, Compound 84::US10172864, Compound 84::US10946023, Compound 84	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279878	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279878&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817107	378161449							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532552	C[C@@H](Nc1nc(NC2(CC2)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C23H23F3N6/c1-14(15-10-11-15)27-20-29-19(17-8-5-9-18(28-17)23(24,25)26)30-21(31-20)32-22(12-13-22)16-6-3-2-4-7-16/h2-9,14-15H,10-13H2,1H3,(H2,27,29,30,31,32)/t14-/m1/s1	MMQKYUIBTNHALE-CQSZACIVSA-N	279883	US10028961, Compound 30::US10028961, Compound 85::US10172864, Compound 85::US10946023, Compound 85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279883	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279883&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466563	378161454							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532555	CC(C)CNc1nc(NC(C)(C)C#N)nc(n1)-c1cc(O)ccc1F	InChI=1S/C17H21FN6O/c1-10(2)8-20-15-21-14(12-7-11(25)5-6-13(12)18)22-16(23-15)24-17(3,4)9-19/h5-7,10,25H,8H2,1-4H3,(H2,20,21,22,23,24)	SXDPYZOSOGORMF-UHFFFAOYSA-N	279936	US10028961, Compound 86::US10172864, Compound 86::US10946023, Compound 86	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279936	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279936&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817467	378161495							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532556	CC(C)CNc1nc(NC(C)(C)C#N)nc(n1)-c1cc(O)ccc1F	InChI=1S/C17H21FN6O/c1-10(2)8-20-15-21-14(12-7-11(25)5-6-13(12)18)22-16(23-15)24-17(3,4)9-19/h5-7,10,25H,8H2,1-4H3,(H2,20,21,22,23,24)	SXDPYZOSOGORMF-UHFFFAOYSA-N	279936	US10028961, Compound 86::US10172864, Compound 86::US10946023, Compound 86	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279936	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279936&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817467	378161495							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532558	C[C@@H](Nc1nc(NC(C)(C)C#N)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C18H20F3N7/c1-10(11-7-8-11)23-15-25-14(26-16(27-15)28-17(2,3)9-22)12-5-4-6-13(24-12)18(19,20)21/h4-6,10-11H,7-8H2,1-3H3,(H2,23,25,26,27,28)/t10-/m1/s1	QDXATNXZLOTYRV-SNVBAGLBSA-N	279890	US10028961, Compound 37::US10028961, Compound 87::US10172864, Compound 87::US10946023, Compound 87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279890	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279890&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817466	378161461							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532560	CCN(CC)c1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(Cl)n1	InChI=1S/C17H23ClN6/c1-4-24(5-2)17-22-15(13-7-6-8-14(18)20-13)21-16(23-17)19-11(3)12-9-10-12/h6-8,11-12H,4-5,9-10H2,1-3H3,(H,19,21,22,23)/t11-/m1/s1	XYQKRMAHYVIZRA-LLVKDONJSA-N	279899	US10028961, Compound 46::US10028961, Compound 88::US10172864, Compound 88::US10946023, Compound 88	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279899	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279899&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817084	378161470							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532562	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)N1CCC1)C1CC1	InChI=1S/C21H29N7/c1-13(15-7-8-15)22-20-25-19(26-21(27-20)23-14(2)16-9-10-16)17-5-3-6-18(24-17)28-11-4-12-28/h3,5-6,13-16H,4,7-12H2,1-2H3,(H2,22,23,25,26,27)/t13-,14-/m1/s1	HSMKSLUXGRHQJU-ZIAGYGMSSA-N	279904	US10028961, Compound 51::US10028961, Compound 89::US10172864, Compound 89::US10946023, Compound 89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279904	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279904&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817093	378161475							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532564	CC(C)(C)OC(=O)N1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C23H28F5N7O2/c1-21(2,3)37-20(36)35-10-8-14(12-35)30-19-33-17(15-5-4-6-16(31-15)23(26,27)28)32-18(34-19)29-13-7-9-22(24,25)11-13/h4-6,13-14H,7-12H2,1-3H3,(H2,29,30,32,33,34)	MDGYQOGSIDPTTI-UHFFFAOYSA-N	279906	US10028961, Compound 53::US10028961, Compound 90::US10172864, Compound 90::US10946023, Compound 90	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279906	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279906&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466417	378161477							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532566	FC(F)(F)c1cccc(n1)-c1nc(NC2CCNC2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H20F5N7/c19-17(20)6-4-10(8-17)25-15-28-14(12-2-1-3-13(27-12)18(21,22)23)29-16(30-15)26-11-5-7-24-9-11/h1-3,10-11,24H,4-9H2,(H2,25,26,28,29,30)	IXFTZPSJWXQNPG-UHFFFAOYSA-N	279907	US10028961, Compound 54::US10028961, Compound 91::US10172864, Compound 91::US10946023, Compound 91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279907	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279907&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466416	378161478							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532568	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccnc1)C1CC1	InChI=1S/C18H24N6/c1-11(13-5-6-13)20-17-22-16(15-4-3-9-19-10-15)23-18(24-17)21-12(2)14-7-8-14/h3-4,9-14H,5-8H2,1-2H3,(H2,20,21,22,23,24)/t11-,12-/m1/s1	GWYWLYIKFLDUMQ-VXGBXAGGSA-N	279910	US10028961, Compound 57::US10028961, Compound 92::US10172864, Compound 92::US10946023, Compound 92	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279910	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279910&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466562	378161481							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532570	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccccn1)C1CC1	InChI=1S/C18H24N6/c1-11(13-6-7-13)20-17-22-16(15-5-3-4-10-19-15)23-18(24-17)21-12(2)14-8-9-14/h3-5,10-14H,6-9H2,1-2H3,(H2,20,21,22,23,24)/t11-,12-/m1/s1	LQIAKXUZNSTYRL-VXGBXAGGSA-N	279914	US10028961, Compound 61::US10028961, Compound 93::US10172864, Compound 93::US10946023, Compound 93	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279914	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279914&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817412	378161485							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532571	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccccc1Cl)C1CC1	InChI=1S/C19H24ClN5/c1-11(13-7-8-13)21-18-23-17(15-5-3-4-6-16(15)20)24-19(25-18)22-12(2)14-9-10-14/h3-6,11-14H,7-10H2,1-2H3,(H2,21,22,23,24,25)/t11-,12-/m1/s1	BFRTUOCWCLMKIN-VXGBXAGGSA-N	279917	US10028961, Compound 66::US10028961, Compound 94::US10172864, Compound 94::US10946023, Compound 94	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279917	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279917&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817340	378161488							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532572	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccncc1)C1CC1	InChI=1S/C18H24N6/c1-11(13-3-4-13)20-17-22-16(15-7-9-19-10-8-15)23-18(24-17)21-12(2)14-5-6-14/h7-14H,3-6H2,1-2H3,(H2,20,21,22,23,24)/t11-,12-/m1/s1	JZOVQRSRIPIGKZ-VXGBXAGGSA-N	279918	US10028961, Compound 67::US10028961, Compound 95::US10172864, Compound 95::US10946023, Compound 95	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279918	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279918&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817342	378161489							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532573	CN1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H22F5N7/c1-31-8-6-12(10-31)26-17-29-15(13-3-2-4-14(27-13)19(22,23)24)28-16(30-17)25-11-5-7-18(20,21)9-11/h2-4,11-12H,5-10H2,1H3,(H2,25,26,28,29,30)	FKUYTXAMGGWNHC-UHFFFAOYSA-N	279946	US10028961, Compound 326::US10028961, Compound 96::US10172864, Compound 96::US10946023, Compound 326	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279946	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279946&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817313	378161496							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532574	C[C@@H](Nc1nc(NC(C(F)(F)F)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C14H10ClF9N6/c1-5(12(16,17)18)25-10-27-8(6-3-2-4-7(15)26-6)28-11(30-10)29-9(13(19,20)21)14(22,23)24/h2-5,9H,1H3,(H2,25,27,28,29,30)/t5-/m1/s1	VTJODCQTJUKOPV-RXMQYKEDSA-N	279947	US10028961, Compound 100::US10172864, Compound 100::US10946023, Compound 100	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279947	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279947&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817515	378161497							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532577	C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)/t6-,7-/m1/s1	QCZAWDGAVJMPTA-RNFRBKRXSA-N	279948	US10028961, Compound 101::US10172864, Compound 101::US10946023, Compound 101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279948	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279948&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	9UO	6VFZ,6VEI,6ADG,6ADI	117817422	378161498							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532582	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(N[C@@H]2CCC(F)(F)C2)n1	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)/t10-,11+	JWMKUJAOIPXYIG-PHIMTYICSA-N	279949	US10028961, Compound 102::US10172864, Compound 102::US10946023, Compound 102	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279949	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279949&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799093	378161499							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532586	CCC(Nc1nc(NC(CC)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C16H17ClF6N6/c1-3-9(15(18,19)20)25-13-27-12(8-6-5-7-11(17)24-8)28-14(29-13)26-10(4-2)16(21,22)23/h5-7,9-10H,3-4H2,1-2H3,(H2,25,26,27,28,29)	SDUBFPITPDQUSW-UHFFFAOYSA-N	279950	US10028961, Compound 103::US10172864, Compound 103::US10946023, Compound 103	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279950	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279950&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817517	378161500							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532590	CC[C@@H](Nc1nc(N[C@H](CC)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C16H17ClF6N6/c1-3-9(15(18,19)20)25-13-27-12(8-6-5-7-11(17)24-8)28-14(29-13)26-10(4-2)16(21,22)23/h5-7,9-10H,3-4H2,1-2H3,(H2,25,26,27,28,29)/t9-,10-/m1/s1	SDUBFPITPDQUSW-NXEZZACHSA-N	279951	US10028961, Compound 104::US10172864, Compound 104::US10946023, Compound 104	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279951	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279951&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817514	378161501							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532594	CC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C20H22F6N6/c1-18(21,22)14-4-2-3-13(29-14)15-30-16(27-11-5-7-19(23,24)9-11)32-17(31-15)28-12-6-8-20(25,26)10-12/h2-4,11-12H,5-10H2,1H3,(H2,27,28,30,31,32)	RZUPVAWGQZNFEZ-UHFFFAOYSA-N	279952	US10028961, Compound 105::US10172864, Compound 105::US10946023, Compound 105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279952	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279952&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817521	378161502							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532599	Fc1cc(F)cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-n2ccc(n2)C(F)(F)F)c1	InChI=1S/C17H12F7N7/c18-8-3-9(19)5-10(4-8)25-13-27-14(26-11-6-16(20,21)7-11)29-15(28-13)31-2-1-12(30-31)17(22,23)24/h1-5,11H,6-7H2,(H2,25,26,27,28,29)	XSFFZJKIWXEYIL-UHFFFAOYSA-N	279953	US10028961, Compound 106::US10172864, Compound 106::US10946023, Compound 106	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279953	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279953&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799077	378161503							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532603	CC(Nc1nc(Nc2cc(F)cc(F)c2)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C16H11F8N7/c1-7(15(19,20)21)25-12-27-13(26-10-5-8(17)4-9(18)6-10)29-14(28-12)31-3-2-11(30-31)16(22,23)24/h2-7H,1H3,(H2,25,26,27,28,29)	AQCLVWSTMGVZRR-UHFFFAOYSA-N	279954	US10028961, Compound 107::US10172864, Compound 107::US10946023, Compound 107	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279954	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279954&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817516	378161504							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532607	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-n2ccc(n2)C(F)(F)F)c1	InChI=1S/C18H14F7N7/c19-9-5-10(20)7-12(6-9)27-15-28-14(26-11-1-3-17(21,22)8-11)29-16(30-15)32-4-2-13(31-32)18(23,24)25/h2,4-7,11H,1,3,8H2,(H2,26,27,28,29,30)	UFZDFINJOJHYMD-UHFFFAOYSA-N	279955	US10028961, Compound 108::US10172864, Compound 108::US10946023, Compound 108	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279955	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279955&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817518	378161505							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532611	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cncc(Cl)n2)c1	InChI=1S/C18H14ClF4N7/c19-14-8-24-7-13(27-14)15-28-16(25-11-1-2-18(22,23)6-11)30-17(29-15)26-12-4-9(20)3-10(21)5-12/h3-5,7-8,11H,1-2,6H2,(H2,25,26,28,29,30)	FQSFRGSJYCFQDI-UHFFFAOYSA-N	279956	US10028961, Compound 109::US10172864, Compound 109::US10946023, Compound 109	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279956	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279956&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799583	378161506							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532614	CCC(Nc1nc(NC(CC)C2CC2)nc(n1)-c1cccc(Cl)n1)C1CC1	InChI=1S/C20H27ClN6/c1-3-14(12-8-9-12)23-19-25-18(16-6-5-7-17(21)22-16)26-20(27-19)24-15(4-2)13-10-11-13/h5-7,12-15H,3-4,8-11H2,1-2H3,(H2,23,24,25,26,27)	SDVGLHHVYYZRJZ-UHFFFAOYSA-N	279957	US10028961, Compound 110::US10172864, Compound 110::US10946023, Compound 110	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279957	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279957&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817125	378161507							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532619	FC(F)(F)c1cccc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(N[C@@H]2CCC(F)(F)C2)n1	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)/t10-,11-/m1/s1	JWMKUJAOIPXYIG-GHMZBOCLSA-N	279958	US10028961, Compound 111::US10172864, Compound 111::US10946023, Compound 111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279958	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279958&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817150	378161508							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532623	Fc1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-n2ccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C19H14F6N8/c20-11-5-10(9-26)6-13(7-11)28-16-29-15(27-12-1-3-18(21,22)8-12)30-17(31-16)33-4-2-14(32-33)19(23,24)25/h2,4-7,12H,1,3,8H2,(H2,27,28,29,30,31)	GOMGSGWMVHCJSA-UHFFFAOYSA-N	279959	US10028961, Compound 112::US10172864, Compound 112::US10946023, Compound 112	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279959	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279959&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817138	378161509							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532627	FC1(F)CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(Cl)n1	InChI=1S/C18H19ClF4N6/c19-13-3-1-2-12(26-13)14-27-15(24-10-4-6-17(20,21)8-10)29-16(28-14)25-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,24,25,27,28,29)	WFTCEDYVKXKHBE-UHFFFAOYSA-N	279960	US10028961, Compound 113::US10172864, Compound 113::US10946023, Compound 113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279960	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279960&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817141	378161510							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532632	C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1csc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C13H11F9N6S/c1-4(11(14,15)16)23-9-26-7(6-3-29-8(25-6)13(20,21)22)27-10(28-9)24-5(2)12(17,18)19/h3-5H,1-2H3,(H2,23,24,26,27,28)/t4-,5-/m1/s1	ZNKBYOAOGUGDDM-RFZPGFLSSA-N	279961	US10028961, Compound 114::US10172864, Compound 114::US10946023, Compound 114	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279961	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279961&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817136	378161511							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532636	FC(F)(F)c1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(Cl)n2)ccn1	InChI=1S/C19H15ClF5N7/c20-14-3-1-2-12(29-14)15-30-16(27-10-5-7-26-13(8-10)19(23,24)25)32-17(31-15)28-11-4-6-18(21,22)9-11/h1-3,5,7-8,11H,4,6,9H2,(H2,26,27,28,30,31,32)	GCDKECOSGNFZAP-UHFFFAOYSA-N	279962	US10028961, Compound 115::US10172864, Compound 115::US10946023, Compound 115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279962	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279962&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798735	378161512							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532641	FC(F)(F)c1cncc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C19H14F8N8/c20-17(21)3-1-10(6-17)31-16-34-14(11-7-28-8-13(32-11)19(25,26)27)33-15(35-16)30-9-2-4-29-12(5-9)18(22,23)24/h2,4-5,7-8,10H,1,3,6H2,(H2,29,30,31,33,34,35)/t10-/m1/s1	ONCVYPCVWHYEJW-SNVBAGLBSA-N	279963	US10028961, Compound 116::US10172864, Compound 116::US10946023, Compound 116	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279963	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279963&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799248	378161513							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532645	CC(C)(C)Nc1nc(Nc2cccc(c2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H18F3N7/c1-19(2,3)30-18-28-16(14-8-5-9-15(26-14)20(21,22)23)27-17(29-18)25-13-7-4-6-12(10-13)11-24/h4-10H,1-3H3,(H2,25,27,28,29,30)	CZMWMJOWERHTGF-UHFFFAOYSA-N	279964	US10028961, Compound 117::US10172864, Compound 117::US10946023, Compound 117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279964	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279964&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799236	378161514							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532650	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(N[C@H]2CCC(F)(F)C2)n1	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)/t10-,11-/m0/s1	JWMKUJAOIPXYIG-QWRGUYRKSA-N	279965	US10028961, Compound 118::US10172864, Compound 118::US10946023, Compound 118	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279965	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279965&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817143	378161515							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532654	CC(Nc1nc(Nc2cc(F)cc(c2)C#N)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C17H11F7N8/c1-8(16(19,20)21)26-13-28-14(27-11-5-9(7-25)4-10(18)6-11)30-15(29-13)32-3-2-12(31-32)17(22,23)24/h2-6,8H,1H3,(H2,26,27,28,29,30)	WXBOZLIIKJDCRJ-UHFFFAOYSA-N	279966	US10028961, Compound 119::US10172864, Compound 119::US10946023, Compound 119	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279966	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279966&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817540	378161516							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532658	Fc1cc(F)cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2cncc(Cl)n2)c1	InChI=1S/C17H12ClF4N7/c18-13-7-23-6-12(26-13)14-27-15(24-10-2-8(19)1-9(20)3-10)29-16(28-14)25-11-4-17(21,22)5-11/h1-3,6-7,11H,4-5H2,(H2,24,25,27,28,29)	DJUDMNYUQIPAHU-UHFFFAOYSA-N	279967	US10028961, Compound 120::US10172864, Compound 120::US10946023, Compound 120	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279967	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279967&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799523	378161517							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532661	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-n1ccc(n1)C(F)(F)F)C1CC1	InChI=1S/C17H22F3N7/c1-9(11-3-4-11)21-14-23-15(22-10(2)12-5-6-12)25-16(24-14)27-8-7-13(26-27)17(18,19)20/h7-12H,3-6H2,1-2H3,(H2,21,22,23,24,25)/t9-,10-/m1/s1	ZFCNVKABVPLJJM-NXEZZACHSA-N	279968	US10028961, Compound 121::US10172864, Compound 121::US10946023, Compound 121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279968	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279968&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817536	378161518							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532666	Fc1cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2nc(cs2)C(F)(F)F)cc(c1)C#N	InChI=1S/C18H11F6N7S/c19-9-1-8(6-25)2-10(3-9)26-15-29-13(14-28-12(7-32-14)18(22,23)24)30-16(31-15)27-11-4-17(20,21)5-11/h1-3,7,11H,4-5H2,(H2,26,27,29,30,31)	MHTOHBOHQAYWJP-UHFFFAOYSA-N	279969	US10028961, Compound 122::US10172864, Compound 122::US10946023, Compound 122	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279969	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279969&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799023	378161519							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532670	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)c1	InChI=1S/C20H15F7N6/c21-10-6-11(22)8-13(7-10)29-18-32-16(14-2-1-3-15(30-14)20(25,26)27)31-17(33-18)28-12-4-5-19(23,24)9-12/h1-3,6-8,12H,4-5,9H2,(H2,28,29,31,32,33)	DTFRDAWQNHNMEU-UHFFFAOYSA-N	279970	US10028961, Compound 123::US10172864, Compound 123::US10946023, Compound 123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279970	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279970&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798777	378161520							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532675	Fc1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C21H15F6N7/c22-12-6-11(10-28)7-14(8-12)30-19-33-17(15-2-1-3-16(31-15)21(25,26)27)32-18(34-19)29-13-4-5-20(23,24)9-13/h1-3,6-8,13H,4-5,9H2,(H2,29,30,32,33,34)	NTKHRYLRDAXKRH-UHFFFAOYSA-N	279971	US10028961, Compound 124::US10172864, Compound 124::US10946023, Compound 124	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279971	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279971&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799282	378161521							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532679	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)CC3)nc(n2)-c2cccc(n2)C(F)(F)F)c1	InChI=1S/C21H17F7N6/c22-11-8-12(23)10-14(9-11)30-19-33-17(15-2-1-3-16(31-15)21(26,27)28)32-18(34-19)29-13-4-6-20(24,25)7-5-13/h1-3,8-10,13H,4-7H2,(H2,29,30,32,33,34)	PEKCODXRCQZWOA-UHFFFAOYSA-N	279972	US10028961, Compound 125::US10172864, Compound 125::US10946023, Compound 125	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279972	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279972&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817565	378161522							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532683	FC(F)(F)c1ccn(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H14F7N7/c16-13(17)3-7(4-13)23-10-25-11(24-8-5-14(18,19)6-8)27-12(26-10)29-2-1-9(28-29)15(20,21)22/h1-2,7-8H,3-6H2,(H2,23,24,25,26,27)	NYHCCPXGTKQDAW-UHFFFAOYSA-N	279973	US10028961, Compound 126::US10172864, Compound 126::US10946023, Compound 126	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279973	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279973&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817544	378161523							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532687	FC1(F)CCC(C1)Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(Cl)n1	InChI=1S/C22H19ClF2N8/c23-17-3-1-2-15(30-17)18-31-19(33-20(32-18)29-14-4-6-22(24,25)11-14)28-13-5-9-27-16(10-13)21(12-26)7-8-21/h1-3,5,9-10,14H,4,6-8,11H2,(H2,27,28,29,31,32,33)	ZENVCUIOSQAXHI-UHFFFAOYSA-N	279974	US10028961, Compound 127::US10172864, Compound 127::US10946023, Compound 127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279974	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279974&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799128	378161524							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532692	FC(F)(F)c1csc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H13F7N6S/c16-13(17)1-6(2-13)23-11-26-9(10-25-8(5-29-10)15(20,21)22)27-12(28-11)24-7-3-14(18,19)4-7/h5-7H,1-4H2,(H2,23,24,26,27,28)	DSJXHLDOLTTWGN-UHFFFAOYSA-N	279975	US10028961, Compound 128::US10172864, Compound 128::US10946023, Compound 128	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279975	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279975&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817465	378161525							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532697	FC1(F)CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cncc(Cl)n1	InChI=1S/C17H18ClF4N7/c18-12-8-23-7-11(26-12)13-27-14(24-9-1-3-16(19,20)5-9)29-15(28-13)25-10-2-4-17(21,22)6-10/h7-10H,1-6H2,(H2,24,25,27,28,29)	RZIGAQYBYPZUMX-UHFFFAOYSA-N	279976	US10028961, Compound 129::US10172864, Compound 129::US10946023, Compound 129	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279976	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279976&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817433	378161526							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532700	CC(Nc1nc(NC(C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)	QCZAWDGAVJMPTA-UHFFFAOYSA-N	279977	US10028961, Compound 130::US10172864, Compound 130::US10946023, Compound 130	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279977	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279977&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	9UO	6VFZ,6VEI,6ADG,6ADI	117817435	378161527							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532705	Clc1cccc(n1)-c1nc(NC(C2CC2)C2CC2)nc(NC(C2CC2)C2CC2)n1	InChI=1S/C22H27ClN6/c23-17-3-1-2-16(24-17)20-27-21(25-18(12-4-5-12)13-6-7-13)29-22(28-20)26-19(14-8-9-14)15-10-11-15/h1-3,12-15,18-19H,4-11H2,(H2,25,26,27,28,29)	UYZPRJVBJGBQLI-UHFFFAOYSA-N	279978	US10028961, Compound 131::US10172864, Compound 131::US10946023, Compound 131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279978	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279978&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817455	378161528							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532709	Fc1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2nc(cs2)C(F)(F)F)cc(c1)[N+]#[C-]	InChI=1S/C19H13F6N7S/c1-26-11-4-9(20)5-12(6-11)28-17-31-14(15-29-13(8-33-15)19(23,24)25)30-16(32-17)27-10-2-3-18(21,22)7-10/h4-6,8,10H,2-3,7H2,(H2,27,28,30,31,32)	KEBOTYHGXMTVHD-UHFFFAOYSA-N	279979	US10028961, Compound 132::US10172864, Compound 132	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279979	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279979&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123723292	378161529							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532713	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C23H19F5N8/c24-22(25)6-4-14(11-22)32-20-35-18(15-2-1-3-16(33-15)23(26,27)28)34-19(36-20)31-13-5-9-30-17(10-13)21(12-29)7-8-21/h1-3,5,9-10,14H,4,6-8,11H2,(H2,30,31,32,34,35,36)/t14-/m0/s1	FQOVWGJWJAOWBO-AWEZNQCLSA-N	279980	US10028961, Compound 133::US10172864, Compound 133::US10946023, Compound 133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279980	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279980&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817510	378161530							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532717	CC(Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C20H16ClF3N8/c1-11(20(22,23)24)27-17-30-16(13-3-2-4-15(21)29-13)31-18(32-17)28-12-5-8-26-14(9-12)19(10-25)6-7-19/h2-5,8-9,11H,6-7H2,1H3,(H2,26,27,28,30,31,32)	CFSIYYWIWLPLNQ-UHFFFAOYSA-N	279981	US10028961, Compound 134::US10172864, Compound 134::US10946023, Compound 134	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279981	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279981&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817443	378161531							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532722	C[C@@H](Nc1nc(NC2CCc3ccccc23)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C23H23F3N6/c1-13(14-9-10-14)27-21-30-20(18-7-4-8-19(28-18)23(24,25)26)31-22(32-21)29-17-12-11-15-5-2-3-6-16(15)17/h2-8,13-14,17H,9-12H2,1H3,(H2,27,29,30,31,32)/t13-,17?/m1/s1	SNCVLWHFGQJUFT-FWJOYPJLSA-N	279982	US10028961, Compound 135::US10172864, Compound 135::US10946023, Compound 135	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279982	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279982&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817509	378161532							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532723	C[C@@H](Nc1nc(N[C@@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)/t6-,7+	QCZAWDGAVJMPTA-KNVOCYPGSA-N	279983	US10028961, Compound 136::US10172864, Compound 136::US10946023, Compound 136	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279983	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279983&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817448	378161533							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532728	FC(F)(F)c1cccc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C23H19F5N8/c24-22(25)6-4-14(11-22)32-20-35-18(15-2-1-3-16(33-15)23(26,27)28)34-19(36-20)31-13-5-9-30-17(10-13)21(12-29)7-8-21/h1-3,5,9-10,14H,4,6-8,11H2,(H2,30,31,32,34,35,36)/t14-/m1/s1	FQOVWGJWJAOWBO-CQSZACIVSA-N	279984	US10028961, Compound 137::US10172864, Compound 137::US10946023, Compound 137	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279984	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279984&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799135	378161534							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532732	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H18F7N7/c19-16(20)3-1-9(5-16)27-14-30-13(11-7-26-8-12(29-11)18(23,24)25)31-15(32-14)28-10-2-4-17(21,22)6-10/h7-10H,1-6H2,(H2,27,28,30,31,32)	YWUBJNPVIIBDPD-UHFFFAOYSA-N	279985	US10028961, Compound 138::US10172864, Compound 138::US10946023, Compound 138	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279985	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279985&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817513	378161535							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532736	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2nc(F)ccc2F)c1	InChI=1S/C19H14F6N6/c20-9-5-10(21)7-12(6-9)27-18-30-16(15-13(22)1-2-14(23)28-15)29-17(31-18)26-11-3-4-19(24,25)8-11/h1-2,5-7,11H,3-4,8H2,(H2,26,27,29,30,31)	NODRFDKTDCPLDT-UHFFFAOYSA-N	279986	US10028961, Compound 139::US10172864, Compound 139::US10946023, Compound 139	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279986	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279986&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817539	378161536							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532739	Fc1cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-n2ccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C18H12F6N8/c19-10-3-9(8-25)4-11(5-10)26-14-28-15(27-12-6-17(20,21)7-12)30-16(29-14)32-2-1-13(31-32)18(22,23)24/h1-5,12H,6-7H2,(H2,26,27,28,29,30)	LDOFFBDPIFZNNG-UHFFFAOYSA-N	279987	US10028961, Compound 140::US10172864, Compound 140::US10946023, Compound 140	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279987	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279987&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799247	378161537							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532743	CC(Nc1nc(NC(C)C(F)(F)F)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C13H12F9N7/c1-5(11(14,15)16)23-8-25-9(24-6(2)12(17,18)19)27-10(26-8)29-4-3-7(28-29)13(20,21)22/h3-6H,1-2H3,(H2,23,24,25,26,27)	FYQXPMJBVPBLMP-UHFFFAOYSA-N	279988	US10028961, Compound 141::US10172864, Compound 141::US10946023, Compound 141	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279988	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279988&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817582	378161538							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532747	C[C@H](Nc1nc(N[C@@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)/t6-,7-/m0/s1	QCZAWDGAVJMPTA-BQBZGAKWSA-N	279989	US10028961, Compound 142::US10172864, Compound 142::US10946023, Compound 142	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279989	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279989&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817339	378161539							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532752	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(5-7-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-8-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	ACLXKIHIMONNBV-UHFFFAOYSA-N	279990	US10028961, Compound 143::US10172864, Compound 143::US10946023, Compound 143	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279990	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279990&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817512	378161540							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532756	FC1(F)CC(C1)Nc1nc(NC2CC(F)(F)C2)nc(n1)-c1cncc(Cl)n1	InChI=1S/C15H14ClF4N7/c16-10-6-21-5-9(24-10)11-25-12(22-7-1-14(17,18)2-7)27-13(26-11)23-8-3-15(19,20)4-8/h5-8H,1-4H2,(H2,22,23,25,26,27)	YLBDZIMKQYQWBZ-UHFFFAOYSA-N	279991	US10028961, Compound 144::US10172864, Compound 144::US10946023, Compound 144	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279991	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279991&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817496	378161541							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532760	FC(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C17H16F6N6/c18-12(19)10-2-1-3-11(26-10)13-27-14(24-8-4-16(20,21)5-8)29-15(28-13)25-9-6-17(22,23)7-9/h1-3,8-9,12H,4-7H2,(H2,24,25,27,28,29)	CMDVCIGBLUTSCG-UHFFFAOYSA-N	279992	US10028961, Compound 145::US10172864, Compound 145::US10946023, Compound 145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279992	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279992&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466129	378161542							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532765	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C17H18F7N7/c18-15(19)4-1-9(7-15)25-12-27-13(26-10-2-5-16(20,21)8-10)29-14(28-12)31-6-3-11(30-31)17(22,23)24/h3,6,9-10H,1-2,4-5,7-8H2,(H2,25,26,27,28,29)	MLJRZPLHOBYNMG-UHFFFAOYSA-N	279993	US10028961, Compound 146::US10172864, Compound 146::US10946023, Compound 146	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279993	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279993&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817473	378161543							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532769	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cncc(Cl)n1	InChI=1S/C19H22ClF4N7/c20-14-10-25-9-13(28-14)15-29-16(26-11-1-5-18(21,22)6-2-11)31-17(30-15)27-12-3-7-19(23,24)8-4-12/h9-12H,1-8H2,(H2,26,27,29,30,31)	MEWHAARPVJKYDP-UHFFFAOYSA-N	279994	US10028961, Compound 147::US10172864, Compound 147::US10946023, Compound 147	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279994	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279994&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817495	378161544							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532774	FC(F)(F)c1csc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C17H17F7N6S/c18-15(19)3-1-8(5-15)25-13-28-11(12-27-10(7-31-12)17(22,23)24)29-14(30-13)26-9-2-4-16(20,21)6-9/h7-9H,1-6H2,(H2,25,26,28,29,30)	CAFOCHZZWAYFKC-UHFFFAOYSA-N	279995	US10028961, Compound 148::US10172864, Compound 148::US10946023, Compound 148	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279995	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279995&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817541	378161545							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532777	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C17H15F7N6/c18-15(19)4-8(5-15)25-13-28-12(10-2-1-3-11(27-10)17(22,23)24)29-14(30-13)26-9-6-16(20,21)7-9/h1-3,8-9H,4-7H2,(H2,25,26,28,29,30)	GJNPRCBREKXFRM-UHFFFAOYSA-N	279996	US10028961, Compound 149::US10172864, Compound 149::US10946023, Compound 149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279996	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279996&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817132	378161546							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532782	Fc1ccc2CC(Cc2c1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C23H20F6N6/c24-14-5-4-12-9-16(10-13(12)8-14)31-21-34-19(17-2-1-3-18(32-17)23(27,28)29)33-20(35-21)30-15-6-7-22(25,26)11-15/h1-5,8,15-16H,6-7,9-11H2,(H2,30,31,33,34,35)	VKNFFJYVRRTAGG-UHFFFAOYSA-N	279997	US10028961, Compound 150::US10172864, Compound 150::US10946023, Compound 150	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279997	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279997&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817109	378161547							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532785	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C23H19F5N8/c1-29-21(8-9-21)17-11-13(6-10-30-17)31-19-34-18(15-3-2-4-16(33-15)23(26,27)28)35-20(36-19)32-14-5-7-22(24,25)12-14/h2-4,6,10-11,14H,5,7-9,12H2,(H2,30,31,32,34,35,36)	LVLCYRFGYKSVJF-UHFFFAOYSA-N	279998	US10028961, Compound 151::US10172864, Compound 151	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279998	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279998&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123318205	378161548							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532790	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccccc3C2)n1	InChI=1S/C23H21F5N6/c24-22(25)9-8-15(12-22)29-20-32-19(17-6-3-7-18(31-17)23(26,27)28)33-21(34-20)30-16-10-13-4-1-2-5-14(13)11-16/h1-7,15-16H,8-12H2,(H2,29,30,32,33,34)	WFJGUJXRROVRQM-UHFFFAOYSA-N	279999	US10028961, Compound 152::US10172864, Compound 152::US10946023, Compound 152	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279999	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279999&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817119	378161549							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532794	Nc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2cc(F)cc(F)c2)n1	InChI=1S/C19H16F5N7/c20-9-5-10(21)7-12(6-9)27-18-30-16(15-13(22)1-2-14(25)28-15)29-17(31-18)26-11-3-4-19(23,24)8-11/h1-2,5-7,11H,3-4,8H2,(H2,25,28)(H2,26,27,29,30,31)	QJZUODUNLOWRRS-UHFFFAOYSA-N	280000	US10028961, Compound 153::US10172864, Compound 153::US10946023, Compound 153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280000	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280000&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799273	378161550							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532798	Fc1cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C20H13F6N7/c21-11-4-10(9-27)5-12(6-11)28-17-31-16(14-2-1-3-15(30-14)20(24,25)26)32-18(33-17)29-13-7-19(22,23)8-13/h1-6,13H,7-8H2,(H2,28,29,31,32,33)	NLDPPNGLSHUYFG-UHFFFAOYSA-N	280001	US10028961, Compound 154::US10172864, Compound 154::US10946023, Compound 154	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280001	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280001&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817126	378161551							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532802	CC(F)(F)c1nc(cs1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H20F6N6S/c1-16(19,20)13-27-11(8-31-13)12-28-14(25-9-2-4-17(21,22)6-9)30-15(29-12)26-10-3-5-18(23,24)7-10/h8-10H,2-7H2,1H3,(H2,25,26,28,29,30)	OMZLJEXLAIMEOS-UHFFFAOYSA-N	280002	US10028961, Compound 155::US10172864, Compound 155::US10946023, Compound 155	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280002	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280002&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817127	378161552							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532806	CC(Nc1nc(NC(C)C(F)(F)F)nc(n1)-c1cncc(Cl)n1)C(F)(F)F	InChI=1S/C13H12ClF6N7/c1-5(12(15,16)17)22-10-25-9(7-3-21-4-8(14)24-7)26-11(27-10)23-6(2)13(18,19)20/h3-6H,1-2H3,(H2,22,23,25,26,27)	QETWKMKQNIKDLH-UHFFFAOYSA-N	280003	US10028961, Compound 156::US10172864, Compound 156::US10946023, Compound 156	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280003	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280003&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817111	378161553							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532810	FC1(F)CCCC1Nc1nc(NC2CCCC2(F)F)nc(n1)-c1cccc(Cl)n1	InChI=1S/C18H19ClF4N6/c19-13-7-1-4-10(24-13)14-27-15(25-11-5-2-8-17(11,20)21)29-16(28-14)26-12-6-3-9-18(12,22)23/h1,4,7,11-12H,2-3,5-6,8-9H2,(H2,25,26,27,28,29)	PDSKCDIBFYQGCE-UHFFFAOYSA-N	280004	US10028961, Compound 157::US10172864, Compound 157::US10946023, Compound 157	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280004	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280004&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817134	378161554							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532814	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H15F8N7/c21-18(22)6-4-11(9-18)31-17-34-15(12-2-1-3-13(32-12)19(23,24)25)33-16(35-17)30-10-5-7-29-14(8-10)20(26,27)28/h1-3,5,7-8,11H,4,6,9H2,(H2,29,30,31,33,34,35)/t11-/m0/s1	PDXMOPYZKDLAPA-NSHDSACASA-N	280005	US10028961, Compound 158::US10172864, Compound 158::US10946023, Compound 158	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280005	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280005&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799020	378161555							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532818	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2nc(cs2)C(F)(F)F)c1	InChI=1S/C18H13F7N6S/c19-8-3-9(20)5-11(4-8)27-16-30-13(14-28-12(7-32-14)18(23,24)25)29-15(31-16)26-10-1-2-17(21,22)6-10/h3-5,7,10H,1-2,6H2,(H2,26,27,29,30,31)	YXCYCZLJJZKMJO-UHFFFAOYSA-N	280006	US10028961, Compound 159::US10172864, Compound 159::US10946023, Compound 159	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280006	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280006&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817493	378161556							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532822	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F7N7/c21-18(22)5-1-11(2-6-18)29-16-32-15(13-9-28-10-14(31-13)20(25,26)27)33-17(34-16)30-12-3-7-19(23,24)8-4-12/h9-12H,1-8H2,(H2,29,30,32,33,34)	SUGBJFIPDULVRS-UHFFFAOYSA-N	280007	US10028961, Compound 160::US10172864, Compound 160::US10946023, Compound 160	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280007	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280007&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817538	378161557							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532826	FC(F)(F)c1cncc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H14F7N7/c17-14(18)1-7(2-14)25-12-28-11(9-5-24-6-10(27-9)16(21,22)23)29-13(30-12)26-8-3-15(19,20)4-8/h5-8H,1-4H2,(H2,25,26,28,29,30)	BJUUMSAHTGGBTK-UHFFFAOYSA-N	280008	US10028961, Compound 161::US10172864, Compound 161::US10946023, Compound 161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280008	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280008&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817567	378161558							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532830	CC(C)(C)Nc1nc(Nc2ccnc(c2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H17F3N8/c1-18(2,3)30-17-28-15(13-5-4-6-14(26-13)19(20,21)22)27-16(29-17)25-11-7-8-24-12(9-11)10-23/h4-9H,1-3H3,(H2,24,25,27,28,29,30)	AJDWHCKBPZAYQS-UHFFFAOYSA-N	280009	US10028961, Compound 162::US10172864, Compound 162::US10946023, Compound 162	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280009	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280009&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799392	378161559							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532834	CC(F)(F)c1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)ccn1	InChI=1S/C21H18F7N7/c1-19(22,23)15-9-11(6-8-29-15)30-17-33-16(13-3-2-4-14(32-13)21(26,27)28)34-18(35-17)31-12-5-7-20(24,25)10-12/h2-4,6,8-9,12H,5,7,10H2,1H3,(H2,29,30,31,33,34,35)	RJZGABPOSOZJRY-UHFFFAOYSA-N	280010	US10028961, Compound 163::US10172864, Compound 163::US10946023, Compound 163	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280010	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280010&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817586	378161560							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532838	Fc1cc(Nc2nc(NC3CCC(F)(F)CC3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C22H17F6N7/c23-13-8-12(11-29)9-15(10-13)31-20-34-18(16-2-1-3-17(32-16)22(26,27)28)33-19(35-20)30-14-4-6-21(24,25)7-5-14/h1-3,8-10,14H,4-7H2,(H2,30,31,33,34,35)	RAQUPWWEGSOPEV-UHFFFAOYSA-N	280011	US10028961, Compound 164::US10172864, Compound 164::US10946023, Compound 164	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280011	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280011&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817554	378161561							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532842	Nc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2cc(F)cc(F)c2)n1	InChI=1S/C20H18F5N7/c21-10-7-11(22)9-13(8-10)28-19-31-17(16-14(23)1-2-15(26)29-16)30-18(32-19)27-12-3-5-20(24,25)6-4-12/h1-2,7-9,12H,3-6H2,(H2,26,29)(H2,27,28,30,31,32)	JAYZPFRYKWCBQZ-UHFFFAOYSA-N	280012	US10028961, Compound 165::US10172864, Compound 165::US10946023, Compound 165	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280012	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280012&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799099	378161562							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532846	COc1ccc2CC(Cc2c1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C24H23F5N6O/c1-36-17-6-5-13-9-16(10-14(13)11-17)31-22-34-20(18-3-2-4-19(32-18)24(27,28)29)33-21(35-22)30-15-7-8-23(25,26)12-15/h2-6,11,15-16H,7-10,12H2,1H3,(H2,30,31,33,34,35)	KUJAJRWAMBXQRE-UHFFFAOYSA-N	280013	US10028961, Compound 166::US10172864, Compound 166::US10946023, Compound 166	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280013	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280013&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817584	378161563							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532848	C[C@@H](Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(Cl)n1)C1CC1	InChI=1S/C22H21ClN8/c1-13(14-5-6-14)26-20-29-19(16-3-2-4-18(23)28-16)30-21(31-20)27-15-7-10-25-17(11-15)22(12-24)8-9-22/h2-4,7,10-11,13-14H,5-6,8-9H2,1H3,(H2,25,26,27,29,30,31)/t13-/m1/s1	YPMMASFCPXGGFB-CYBMUJFWSA-N	280014	US10028961, Compound 167::US10172864, Compound 167::US10946023, Compound 167	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280014	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280014&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799158	378161564							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532852	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C22H17F5N8/c1-28-20(6-7-20)16-9-12(5-8-29-16)30-18-33-17(14-3-2-4-15(32-14)22(25,26)27)34-19(35-18)31-13-10-21(23,24)11-13/h2-5,8-9,13H,6-7,10-11H2,(H2,29,30,31,33,34,35)	MNROPBMECNHKDS-UHFFFAOYSA-N	280015	US10028961, Compound 168::US10172864, Compound 168	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280015	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280015&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123886256	378161565							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532856	FC(F)(F)c1ccn(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C20H16F5N9/c1-26-18(4-5-18)14-8-11(2-6-27-14)28-15-30-16(29-12-9-19(21,22)10-12)32-17(31-15)34-7-3-13(33-34)20(23,24)25/h2-3,6-8,12H,4-5,9-10H2,(H2,27,28,29,30,31,32)	BYFJDMHRGJRSCN-UHFFFAOYSA-N	280016	US10028961, Compound 169::US10172864, Compound 169	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280016	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280016&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124026281	378161566							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532860	FC(F)(F)c1nc(cs1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H13F7N6S/c16-13(17)1-6(2-13)23-11-26-9(8-5-29-10(25-8)15(20,21)22)27-12(28-11)24-7-3-14(18,19)4-7/h5-7H,1-4H2,(H2,23,24,26,27,28)	PFVOIDGYPOBGID-UHFFFAOYSA-N	280017	US10028961, Compound 170::US10172864, Compound 170::US10946023, Compound 170	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280017	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280017&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817334	378161567							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532864	CC(Nc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C18H12F9N7/c1-8(16(19,20)21)29-14-32-13(10-3-2-4-11(31-10)17(22,23)24)33-15(34-14)30-9-5-6-28-12(7-9)18(25,26)27/h2-8H,1H3,(H2,28,29,30,32,33,34)	RJRSWUFHCKWNQG-UHFFFAOYSA-N	280018	US10028961, Compound 171::US10172864, Compound 171::US10946023, Compound 171	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280018	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280018&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799090	378161568							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532868	FC(F)(F)c1cccc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H15F8N7/c21-18(22)6-4-11(9-18)31-17-34-15(12-2-1-3-13(32-12)19(23,24)25)33-16(35-17)30-10-5-7-29-14(8-10)20(26,27)28/h1-3,5,7-8,11H,4,6,9H2,(H2,29,30,31,33,34,35)/t11-/m1/s1	PDXMOPYZKDLAPA-LLVKDONJSA-N	280019	US10028961, Compound 172::US10172864, Compound 172::US10946023, Compound 172	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280019	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280019&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798963	378161569							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532872	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C18H14F8N8/c19-16(20)4-1-10(8-16)29-14-30-13(28-9-2-5-27-12(7-9)18(24,25)26)31-15(32-14)34-6-3-11(33-34)17(21,22)23/h2-3,5-7,10H,1,4,8H2,(H2,27,28,29,30,31,32)	RACFSMUYWZWUMF-UHFFFAOYSA-N	280020	US10028961, Compound 173::US10172864, Compound 173::US10946023, Compound 173	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280020	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280020&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798964	378161570							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532876	FC(F)(F)c1ccn(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C21H18F5N9/c1-27-19(6-7-19)15-10-12(3-8-28-15)29-16-31-17(30-13-2-5-20(22,23)11-13)33-18(32-16)35-9-4-14(34-35)21(24,25)26/h3-4,8-10,13H,2,5-7,11H2,(H2,28,29,30,31,32,33)/t13-/m0/s1	ZSYUHTUAGISLHX-ZDUSSCGKSA-N	280021	US10028961, Compound 174::US10172864, Compound 174	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280021	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280021&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123271414	378161571							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532880	Fc1cc(Nc2nc(NCC3CC3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)[N+]#[C-]	InChI=1S/C20H15F4N7/c1-25-13-7-12(21)8-14(9-13)27-19-30-17(29-18(31-19)26-10-11-5-6-11)15-3-2-4-16(28-15)20(22,23)24/h2-4,7-9,11H,5-6,10H2,(H2,26,27,29,30,31)	JVFNMBJVSBMSCG-UHFFFAOYSA-N	280022	US10028961, Compound 175::US10172864, Compound 175	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280022	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280022&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123300524	378161572							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532884	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H22F7N7/c20-17(21)6-1-11(2-7-17)27-14-29-15(28-12-3-8-18(22,23)9-4-12)31-16(30-14)33-10-5-13(32-33)19(24,25)26/h5,10-12H,1-4,6-9H2,(H2,27,28,29,30,31)	SLPLEYMIEBFOSW-UHFFFAOYSA-N	280023	US10028961, Compound 176::US10172864, Compound 176::US10946023, Compound 176	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280023	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280023&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817355	378161573							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532889	CC(Nc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C16H11F9N8/c1-7(14(17,18)19)27-11-29-12(28-8-2-4-26-10(6-8)16(23,24)25)31-13(30-11)33-5-3-9(32-33)15(20,21)22/h2-7H,1H3,(H2,26,27,28,29,30,31)	ORPDRKJAHZEOLR-UHFFFAOYSA-N	280024	US10028961, Compound 177::US10172864, Compound 177::US10946023, Compound 177	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280024	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280024&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817357	378161574							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532893	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H15F8N7/c21-18(22)6-4-11(9-18)31-17-34-15(12-2-1-3-13(32-12)19(23,24)25)33-16(35-17)30-10-5-7-29-14(8-10)20(26,27)28/h1-3,5,7-8,11H,4,6,9H2,(H2,29,30,31,33,34,35)	PDXMOPYZKDLAPA-UHFFFAOYSA-N	280025	US10028961, Compound 178::US10172864, Compound 178::US10946023, Compound 178	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280025	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280025&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798985	378161575							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532898	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C18H14F5N9/c19-17(20)4-1-11(8-17)27-15-28-14(26-10-2-5-25-12(7-10)9-24)29-16(30-15)32-6-3-13(31-32)18(21,22)23/h2-3,5-7,11H,1,4,8H2,(H2,25,26,27,28,29,30)	LUJOXCPZQNCMMB-UHFFFAOYSA-N	280026	US10028961, Compound 179::US10172864, Compound 179::US10946023, Compound 179	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280026	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280026&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817116	378161576							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532902	CC[C@H](Nc1nc(N[C@@H](CC)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C16H17ClF6N6/c1-3-9(15(18,19)20)25-13-27-12(8-6-5-7-11(17)24-8)28-14(29-13)26-10(4-2)16(21,22)23/h5-7,9-10H,3-4H2,1-2H3,(H2,25,26,27,28,29)/t9-,10-/m0/s1	SDUBFPITPDQUSW-UWVGGRQHSA-N	280027	US10028961, Compound 180::US10172864, Compound 180::US10946023, Compound 180	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280027	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280027&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817137	378161577							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532906	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C20H15F5N8/c21-19(22)6-4-12(9-19)29-18-32-16(14-2-1-3-15(30-14)20(23,24)25)31-17(33-18)28-11-5-7-27-13(8-11)10-26/h1-3,5,7-8,12H,4,6,9H2,(H2,27,28,29,31,32,33)	CPONOLJSMXHPCO-UHFFFAOYSA-N	280028	US10028961, Compound 181::US10172864, Compound 181::US10946023, Compound 181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280028	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280028&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799213	378161578							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532911	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccc(Cl)cc3C2)n1	InChI=1S/C23H20ClF5N6/c24-14-5-4-12-9-16(10-13(12)8-14)31-21-34-19(17-2-1-3-18(32-17)23(27,28)29)33-20(35-21)30-15-6-7-22(25,26)11-15/h1-5,8,15-16H,6-7,9-11H2,(H2,30,31,33,34,35)	XWCYRXFAEIUJMO-UHFFFAOYSA-N	280029	US10028961, Compound 182::US10172864, Compound 182::US10946023, Compound 182	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280029	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280029&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817114	378161579							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532915	FC(F)(F)c1csc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H21F7N6S/c20-17(21)5-1-10(2-6-17)27-15-30-13(14-29-12(9-33-14)19(24,25)26)31-16(32-15)28-11-3-7-18(22,23)8-4-11/h9-11H,1-8H2,(H2,27,28,30,31,32)	AKRQSKYNRTUAQA-UHFFFAOYSA-N	280030	US10028961, Compound 183::US10172864, Compound 183::US10946023, Compound 183	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280030	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280030&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817122	378161580							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532919	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(C2)c2ccccc2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C25H25F5N6/c26-24(27)12-11-18(14-24)32-23-35-21(19-7-4-8-20(33-19)25(28,29)30)34-22(36-23)31-17-10-9-16(13-17)15-5-2-1-3-6-15/h1-8,16-18H,9-14H2,(H2,31,32,34,35,36)	VFMVBGKNWIWEDT-UHFFFAOYSA-N	280031	US10028961, Compound 184::US10172864, Compound 184::US10946023, Compound 184	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280031	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280031&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817117	378161581							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532922	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C21H18F5N9/c22-20(23)4-1-13(10-20)30-17-31-16(29-12-2-7-28-15(9-12)19(11-27)5-6-19)32-18(33-17)35-8-3-14(34-35)21(24,25)26/h2-3,7-9,13H,1,4-6,10H2,(H2,28,29,30,31,32,33)	WFGLMCWPQJGAJJ-UHFFFAOYSA-N	280032	US10028961, Compound 185::US10172864, Compound 185::US10946023, Compound 185	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280032	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280032&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799291	378161582							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532926	FC(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H23F6N7/c21-15(22)13-9-27-10-14(30-13)16-31-17(28-11-1-5-19(23,24)6-2-11)33-18(32-16)29-12-3-7-20(25,26)8-4-12/h9-12,15H,1-8H2,(H2,28,29,31,32,33)	NNVCNVORYXXOAM-UHFFFAOYSA-N	280033	US10028961, Compound 186::US10172864, Compound 186::US10946023, Compound 186	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280033	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280033&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817121	378161583							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532930	CC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C18H18F6N6/c1-16(19,20)12-4-2-3-11(27-12)13-28-14(25-9-5-17(21,22)6-9)30-15(29-13)26-10-7-18(23,24)8-10/h2-4,9-10H,5-8H2,1H3,(H2,25,26,28,29,30)	YRSZQQILDIHZRT-UHFFFAOYSA-N	280034	US10028961, Compound 187::US10172864, Compound 187::US10946023, Compound 187	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280034	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280034&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817115	378161584							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532934	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3cccnc3C2)n1	InChI=1S/C22H20F5N7/c23-21(24)7-6-13(11-21)29-19-32-18(15-4-1-5-17(31-15)22(25,26)27)33-20(34-19)30-14-9-12-3-2-8-28-16(12)10-14/h1-5,8,13-14H,6-7,9-11H2,(H2,29,30,32,33,34)	UUDARVDQIIXFAL-UHFFFAOYSA-N	280035	US10028961, Compound 188::US10172864, Compound 188::US10946023, Compound 188	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280035	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280035&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817139	378161585							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532936	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C24H21F5N8/c1-30-22(10-11-22)18-13-15(7-12-31-18)33-21-36-19(16-3-2-4-17(34-16)24(27,28)29)35-20(37-21)32-14-5-8-23(25,26)9-6-14/h2-4,7,12-14H,5-6,8-11H2,(H2,31,32,33,35,36,37)	RLVMMYRYFBQTDM-UHFFFAOYSA-N	280036	US10028961, Compound 189::US10172864, Compound 189	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280036	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280036&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123396437	378161586							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532941	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C19H13F8N7/c20-17(21)7-10(8-17)30-16-33-14(11-2-1-3-12(31-11)18(22,23)24)32-15(34-16)29-9-4-5-28-13(6-9)19(25,26)27/h1-6,10H,7-8H2,(H2,28,29,30,32,33,34)	VURZKJCJGOOOFL-UHFFFAOYSA-N	280037	US10028961, Compound 190::US10172864, Compound 190::US10946023, Compound 190	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280037	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280037&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817505	378161587							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532945	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C21H21F7N6/c22-19(23)5-4-11(8-19)29-16-32-15(13-2-1-3-14(31-13)21(26,27)28)33-17(34-16)30-12-6-18(7-12)9-20(24,25)10-18/h1-3,11-12H,4-10H2,(H2,29,30,32,33,34)	RHCDZLRZYCRNDX-UHFFFAOYSA-N	280038	US10028961, Compound 191::US10172864, Compound 191::US10946023, Compound 191	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280038	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280038&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817431	378161588							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532950	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C21H17F8N7/c22-19(23)7-4-11(5-8-19)31-17-34-16(13-2-1-3-14(33-13)20(24,25)26)35-18(36-17)32-12-6-9-30-15(10-12)21(27,28)29/h1-3,6,9-11H,4-5,7-8H2,(H2,30,31,32,34,35,36)	ODBLPFGHFKRKHG-UHFFFAOYSA-N	280039	US10028961, Compound 192::US10172864, Compound 192::US10946023, Compound 192	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280039	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280039&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798913	378161589							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532955	C[C@@H](Nc1nc(NC(C2CC2)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C21H25F3N6/c1-11(12-5-6-12)25-19-28-18(15-3-2-4-16(26-15)21(22,23)24)29-20(30-19)27-17(13-7-8-13)14-9-10-14/h2-4,11-14,17H,5-10H2,1H3,(H2,25,27,28,29,30)/t11-/m1/s1	IEWNKIUGPADRRO-LLVKDONJSA-N	280040	US10028961, Compound 193::US10172864, Compound 193::US10946023, Compound 193	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280040	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280040&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817507	378161590							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532959	FC(F)(F)c1nccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H18F7N7/c19-16(20)4-1-9(7-16)27-14-30-12(11-3-6-26-13(29-11)18(23,24)25)31-15(32-14)28-10-2-5-17(21,22)8-10/h3,6,9-10H,1-2,4-5,7-8H2,(H2,27,28,30,31,32)	VWUHSVAZJFWQPW-UHFFFAOYSA-N	280041	US10028961, Compound 194::US10172864, Compound 194::US10946023, Compound 194	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280041	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280041&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817504	378161591							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532963	Fc1cc(F)cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2nc(F)ccc2F)c1	InChI=1S/C18H12F6N6/c19-8-3-9(20)5-10(4-8)25-16-28-15(14-12(21)1-2-13(22)27-14)29-17(30-16)26-11-6-18(23,24)7-11/h1-5,11H,6-7H2,(H2,25,26,28,29,30)	YOKUNNSAZUOEON-UHFFFAOYSA-N	280042	US10028961, Compound 195::US10172864, Compound 195::US10946023, Compound 195	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280042	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280042&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798724	378161592							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532967	CC[C@@H](Nc1nc(N[C@@H](CC)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C16H17ClF6N6/c1-3-9(15(18,19)20)25-13-27-12(8-6-5-7-11(17)24-8)28-14(29-13)26-10(4-2)16(21,22)23/h5-7,9-10H,3-4H2,1-2H3,(H2,25,26,27,28,29)/t9-,10+	SDUBFPITPDQUSW-AOOOYVTPSA-N	280043	US10028961, Compound 196::US10172864, Compound 196::US10946023, Compound 196	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280043	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280043&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817506	378161593							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532971	FC(F)(F)c1ccn(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C17H12F8N8/c18-15(19)6-9(7-15)28-13-29-12(27-8-1-3-26-11(5-8)17(23,24)25)30-14(31-13)33-4-2-10(32-33)16(20,21)22/h1-5,9H,6-7H2,(H2,26,27,28,29,30,31)	GIXRLAOMSYYYTD-UHFFFAOYSA-N	280044	US10028961, Compound 197::US10172864, Compound 197::US10946023, Compound 197	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280044	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280044&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798951	378161594							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532975	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)F)C1CC1	InChI=1S/C19H24F2N6/c1-10(12-6-7-12)22-18-25-17(15-5-3-4-14(24-15)16(20)21)26-19(27-18)23-11(2)13-8-9-13/h3-5,10-13,16H,6-9H2,1-2H3,(H2,22,23,25,26,27)/t10-,11-/m1/s1	OHIIKMKNLSEDJI-GHMZBOCLSA-N	280045	US10028961, Compound 198::US10172864, Compound 198::US10946023, Compound 198	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280045	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280045&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817508	378161595							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532978	Fc1ccc(cc1)[C@@H]1C[C@@H](C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C24H22F6N6/c25-15-6-4-13(5-7-15)14-10-17(11-14)32-22-35-20(18-2-1-3-19(33-18)24(28,29)30)34-21(36-22)31-16-8-9-23(26,27)12-16/h1-7,14,16-17H,8-12H2,(H2,31,32,34,35,36)/t14-,16?,17+	MVZVTAYGMMCXIJ-FHQBBSRKSA-N	280046	US10028961, Compound 199::US10172864, Compound 199::US10946023, Compound 199	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280046	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280046&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817184	378161596							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532982	FC(F)(F)c1cc(Nc2nc(NCC3CC3)nc(n2)-c2cccc(Cl)n2)ccn1	InChI=1S/C18H15ClF3N7/c19-14-3-1-2-12(26-14)15-27-16(24-9-10-4-5-10)29-17(28-15)25-11-6-7-23-13(8-11)18(20,21)22/h1-3,6-8,10H,4-5,9H2,(H2,23,24,25,27,28,29)	ZMPPKTRRHWZFFR-UHFFFAOYSA-N	280047	US10028961, Compound 200::US10172864, Compound 200::US10946023, Compound 200	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280047	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280047&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798795	378161597							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532986	CC(Nc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C19H15F6N9/c1-10(18(20,21)22)28-14-30-15(29-11-3-7-27-13(9-11)17(26-2)5-6-17)32-16(31-14)34-8-4-12(33-34)19(23,24)25/h3-4,7-10H,5-6H2,1H3,(H2,27,28,29,30,31,32)	OQCGRHOQNOOHFP-UHFFFAOYSA-N	280048	US10028961, Compound 201::US10172864, Compound 201	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280048	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280048&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124000502	378161598							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532990	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)-c2ccccc2)n1	InChI=1S/C25H20F5N7/c26-24(27)11-9-17(14-24)33-23-36-21(18-7-4-8-20(34-18)25(28,29)30)35-22(37-23)32-16-10-12-31-19(13-16)15-5-2-1-3-6-15/h1-8,10,12-13,17H,9,11,14H2,(H2,31,32,33,35,36,37)	WBCWQBKLLSFRCG-UHFFFAOYSA-N	280049	US10028961, Compound 202::US10172864, Compound 202::US10946023, Compound 202	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280049	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280049&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798716	378161599							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532994	C[C@@H](Nc1nc(NC(C)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C17H18F6N6/c1-8(10-6-7-10)24-14-27-13(11-4-3-5-12(26-11)17(21,22)23)28-15(29-14)25-9(2)16(18,19)20/h3-5,8-10H,6-7H2,1-2H3,(H2,24,25,27,28,29)/t8-,9?/m1/s1	AFJDSJYOWKPURG-VEDVMXKPSA-N	280050	US10028961, Compound 203::US10172864, Compound 203::US10946023, Compound 203	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280050	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280050&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817231	378161600							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
532999	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C21H17F5N8/c22-20(23)7-4-12(5-8-20)29-18-32-17(15-2-1-3-16(31-15)21(24,25)26)33-19(34-18)30-13-6-9-28-14(10-13)11-27/h1-3,6,9-10,12H,4-5,7-8H2,(H2,28,29,30,32,33,34)	DWYLFGVHVCAESV-UHFFFAOYSA-N	280051	US10028961, Compound 204::US10172864, Compound 204::US10946023, Compound 204	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280051	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280051&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817471	378161601							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533002	FC(F)c1csc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H22F6N6S/c20-13(21)12-9-32-15(28-12)14-29-16(26-10-1-5-18(22,23)6-2-10)31-17(30-14)27-11-3-7-19(24,25)8-4-11/h9-11,13H,1-8H2,(H2,26,27,29,30,31)	KXYSDNWDMNWMPI-UHFFFAOYSA-N	280052	US10028961, Compound 205::US10172864, Compound 205::US10946023, Compound 205	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280052	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280052&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817472	378161602							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533006	CC(Cc1ccccc1)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C23H25F3N6/c1-14(13-16-7-4-3-5-8-16)27-21-30-20(18-9-6-10-19(29-18)23(24,25)26)31-22(32-21)28-15(2)17-11-12-17/h3-10,14-15,17H,11-13H2,1-2H3,(H2,27,28,30,31,32)/t14?,15-/m1/s1	VUQFMBNQHKOABY-YSSOQSIOSA-N	280053	US10028961, Compound 206::US10172864, Compound 206::US10946023, Compound 206	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280053	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280053&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817468	378161603							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533007	C[C@@H](Nc1nc(Nc2ccnc(c2)C#N)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C16H11F6N9/c1-8(15(17,18)19)25-12-27-13(26-9-2-4-24-10(6-9)7-23)29-14(28-12)31-5-3-11(30-31)16(20,21)22/h2-6,8H,1H3,(H2,24,25,26,27,28,29)/t8-/m1/s1	WPINTHZUZYAPQF-MRVPVSSYSA-N	280054	US10028961, Compound 207::US10172864, Compound 207::US10946023, Compound 207	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280054	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280054&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817469	378161604							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533011	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(C2)c2ccccc2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C24H23F5N6/c25-23(26)10-9-16(13-23)30-21-33-20(18-7-4-8-19(32-18)24(27,28)29)34-22(35-21)31-17-11-15(12-17)14-5-2-1-3-6-14/h1-8,15-17H,9-13H2,(H2,30,31,33,34,35)	FNNAHAWBMDYWEW-UHFFFAOYSA-N	280055	US10028961, Compound 208::US10172864, Compound 208::US10946023, Compound 208	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280055	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280055&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799210	378161605							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533012	CC(F)(F)c1nc(cs1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H16F6N6S/c1-14(17,18)11-25-9(6-29-11)10-26-12(23-7-2-15(19,20)3-7)28-13(27-10)24-8-4-16(21,22)5-8/h6-8H,2-5H2,1H3,(H2,23,24,26,27,28)	RGHZRMLVPJRYFM-UHFFFAOYSA-N	280056	US10028961, Compound 209::US10172864, Compound 209::US10946023, Compound 209	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280056	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280056&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817148	378161606							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533016	FC(F)(F)c1ccn(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C17H12F5N9/c18-16(19)6-11(7-16)26-14-27-13(25-9-1-3-24-10(5-9)8-23)28-15(29-14)31-4-2-12(30-31)17(20,21)22/h1-5,11H,6-7H2,(H2,24,25,26,27,28,29)	UDPIYDLIPGHOFT-UHFFFAOYSA-N	280057	US10028961, Compound 210::US10172864, Compound 210::US10946023, Compound 210	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280057	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280057&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799025	378161607							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533020	CC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C25H24F4N8/c1-23(26,27)18-4-2-3-17(34-18)20-35-21(32-15-5-8-25(28,29)9-6-15)37-22(36-20)33-16-7-12-31-19(13-16)24(14-30)10-11-24/h2-4,7,12-13,15H,5-6,8-11H2,1H3,(H2,31,32,33,35,36,37)	QRMZPBWPZWIROS-UHFFFAOYSA-N	280058	US10028961, Compound 211::US10172864, Compound 211::US10946023, Compound 211	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280058	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280058&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817159	378161608							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533024	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(Cl)n1	InChI=1S/C20H23ClF4N6/c21-15-3-1-2-14(28-15)16-29-17(26-12-4-8-19(22,23)9-5-12)31-18(30-16)27-13-6-10-20(24,25)11-7-13/h1-3,12-13H,4-11H2,(H2,26,27,29,30,31)	UIBBMCJNFUASJY-UHFFFAOYSA-N	280059	US10028961, Compound 212::US10172864, Compound 212::US10946023, Compound 212	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280059	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280059&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817149	378161609							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533028	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C19H13F5N8/c20-18(21)7-12(8-18)28-17-31-15(13-2-1-3-14(29-13)19(22,23)24)30-16(32-17)27-10-4-5-26-11(6-10)9-25/h1-6,12H,7-8H2,(H2,26,27,28,30,31,32)	RQRJJSVAJSUINU-UHFFFAOYSA-N	280060	US10028961, Compound 213::US10172864, Compound 213::US10946023, Compound 213	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280060	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280060&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817155	378161610							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533032	CC(CC#N)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C18H20F3N7/c1-10(8-9-22)23-16-26-15(13-4-3-5-14(25-13)18(19,20)21)27-17(28-16)24-11(2)12-6-7-12/h3-5,10-12H,6-8H2,1-2H3,(H2,23,24,26,27,28)/t10?,11-/m1/s1	IFMDZJNJPFFCSK-RRKGBCIJSA-N	280061	US10028961, Compound 214::US10172864, Compound 214::US10946023, Compound 214	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280061	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280061&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799309	378161611							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533036	FC(F)(F)CNc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-c1cccc(Cl)n1	InChI=1S/C19H14ClF3N8/c1-24-18(6-7-18)13-9-11(5-8-25-13)27-17-30-15(12-3-2-4-14(20)28-12)29-16(31-17)26-10-19(21,22)23/h2-5,8-9H,6-7,10H2,(H2,25,26,27,29,30,31)	RJYPNTZBJZUSPV-UHFFFAOYSA-N	280062	US10028961, Compound 215::US10172864, Compound 215	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280062	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280062&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124015477	378161612							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533040	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC(F)(F)C2)nc(NCC2CC(F)(F)C2)n1	InChI=1S/C19H19F7N6/c20-17(21)4-10(5-17)8-27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-9-11-6-18(22,23)7-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	OSLHWFZOOADJCB-UHFFFAOYSA-N	280063	US10028961, Compound 216::US10172864, Compound 216::US10946023, Compound 216	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280063	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280063&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817178	378161613							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533044	CC(Nc1nc(Nc2ccnc(c2)-c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C23H17F6N7/c1-13(22(24,25)26)31-20-34-19(16-8-5-9-18(33-16)23(27,28)29)35-21(36-20)32-15-10-11-30-17(12-15)14-6-3-2-4-7-14/h2-13H,1H3,(H2,30,31,32,34,35,36)	NWTISIXHXPIMSM-UHFFFAOYSA-N	280064	US10028961, Compound 217::US10172864, Compound 217::US10946023, Compound 217	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280064	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280064&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817152	378161614							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533048	CC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C22H26F6N6/c1-20(23,24)16-4-2-3-15(31-16)17-32-18(29-13-5-9-21(25,26)10-6-13)34-19(33-17)30-14-7-11-22(27,28)12-8-14/h2-4,13-14H,5-12H2,1H3,(H2,29,30,32,33,34)	NAVGNOHPZVGLBF-UHFFFAOYSA-N	280065	US10028961, Compound 218::US10172864, Compound 218::US10946023, Compound 218	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280065	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280065&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817160	378161615							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533052	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)c2ccccc2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C24H24F5N7/c25-23(26)11-9-15(13-23)30-21-33-20(18-7-4-8-19(32-18)24(27,28)29)34-22(35-21)31-16-10-12-36(14-16)17-5-2-1-3-6-17/h1-8,15-16H,9-14H2,(H2,30,31,33,34,35)	ATYUYZMINSFJHA-UHFFFAOYSA-N	280066	US10028961, Compound 219::US10172864, Compound 219::US10946023, Compound 219	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280066	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280066&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817049	378161616							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533053	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)-c2ccccc2)n1	InChI=1S/C26H22F5N7/c27-25(28)12-9-17(10-13-25)33-23-36-22(19-7-4-8-21(35-19)26(29,30)31)37-24(38-23)34-18-11-14-32-20(15-18)16-5-2-1-3-6-16/h1-8,11,14-15,17H,9-10,12-13H2,(H2,32,33,34,36,37,38)	WTQROKONFNCZLX-UHFFFAOYSA-N	280067	US10028961, Compound 220::US10172864, Compound 220::US10946023, Compound 220	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280067	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280067&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798796	378161617							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533057	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H15F8N7/c21-18(22)7-10(8-18)9-30-16-33-15(12-2-1-3-13(32-12)19(23,24)25)34-17(35-16)31-11-4-5-29-14(6-11)20(26,27)28/h1-6,10H,7-9H2,(H2,29,30,31,33,34,35)	OWAVUCAENWNGFB-UHFFFAOYSA-N	280068	US10028961, Compound 221::US10172864, Compound 221::US10946023, Compound 221	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280068	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280068&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799308	378161618							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533061	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)c2ccccn2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C23H23F5N8/c24-22(25)9-7-14(12-22)30-20-33-19(16-4-3-5-17(32-16)23(26,27)28)34-21(35-20)31-15-8-11-36(13-15)18-6-1-2-10-29-18/h1-6,10,14-15H,7-9,11-13H2,(H2,30,31,33,34,35)	TYLCUGJKUXBFOZ-UHFFFAOYSA-N	280069	US10028961, Compound 222::US10172864, Compound 222::US10946023, Compound 222	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280069	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280069&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817038	378161619							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533065	FC(F)(F)c1nc(cs1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H21F7N6S/c20-17(21)5-1-10(2-6-17)27-15-30-13(12-9-33-14(29-12)19(24,25)26)31-16(32-15)28-11-3-7-18(22,23)8-4-11/h9-11H,1-8H2,(H2,27,28,30,31,32)	PFTFOLWIPCINKJ-UHFFFAOYSA-N	280070	US10028961, Compound 223::US10172864, Compound 223::US10946023, Compound 223	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280070	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280070&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817026	378161620							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533069	FC(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H24F6N6/c22-16(23)14-2-1-3-15(30-14)17-31-18(28-12-4-8-20(24,25)9-5-12)33-19(32-17)29-13-6-10-21(26,27)11-7-13/h1-3,12-13,16H,4-11H2,(H2,28,29,31,32,33)	VPZNRBLRTQODKB-UHFFFAOYSA-N	280071	US10028961, Compound 224::US10172864, Compound 224::US10946023, Compound 224	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280071	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280071&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817029	378161621							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533074	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccc(Br)cc3C2)n1	InChI=1S/C23H20BrF5N6/c24-14-5-4-12-9-16(10-13(12)8-14)31-21-34-19(17-2-1-3-18(32-17)23(27,28)29)33-20(35-21)30-15-6-7-22(25,26)11-15/h1-5,8,15-16H,6-7,9-11H2,(H2,30,31,33,34,35)	VVBVABDTGIHRLF-UHFFFAOYSA-N	280072	US10028961, Compound 225::US10172864, Compound 225::US10946023, Compound 225	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280072	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280072&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817025	378161622							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533075	FC(F)(F)CNc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H14F6N8/c1-27-18(6-7-18)14-9-11(5-8-28-14)30-17-33-15(32-16(34-17)29-10-19(21,22)23)12-3-2-4-13(31-12)20(24,25)26/h2-5,8-9H,6-7,10H2,(H2,28,29,30,32,33,34)	PFZLERVPZNDZDD-UHFFFAOYSA-N	280073	US10028961, Compound 226::US10172864, Compound 226	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280073	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280073&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123942898	378161623							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533079	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)c2ncccn2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C22H22F5N9/c23-21(24)7-5-13(11-21)30-18-33-17(15-3-1-4-16(32-15)22(25,26)27)34-19(35-18)31-14-6-10-36(12-14)20-28-8-2-9-29-20/h1-4,8-9,13-14H,5-7,10-12H2,(H2,30,31,33,34,35)	YPXQHURHYKDPKF-UHFFFAOYSA-N	280074	US10028961, Compound 227::US10172864, Compound 227::US10946023, Compound 227	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280074	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280074&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817030	378161624							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533083	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C22H23F7N6/c23-20(24)6-4-12(5-7-20)30-17-33-16(14-2-1-3-15(32-14)22(27,28)29)34-18(35-17)31-13-8-19(9-13)10-21(25,26)11-19/h1-3,12-13H,4-11H2,(H2,30,31,33,34,35)	MBSONQUQQPPYRL-UHFFFAOYSA-N	280075	US10028961, Compound 228::US10172864, Compound 228::US10946023, Compound 228	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280075	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280075&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817032	378161625							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533086	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C25H21F5N8/c1-31-23(6-7-23)18-9-14(5-8-32-18)33-20-36-19(16-3-2-4-17(35-16)25(28,29)30)37-21(38-20)34-15-10-22(11-15)12-24(26,27)13-22/h2-5,8-9,15H,6-7,10-13H2,(H2,32,33,34,36,37,38)	QOYBVQHDVXHECC-UHFFFAOYSA-N	280076	US10028961, Compound 229::US10172864, Compound 229	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280076	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280076&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123245946	378161626							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533091	Fc1ccc(cc1)[C@H]1C[C@@H](C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C24H22F6N6/c25-15-6-4-13(5-7-15)14-10-17(11-14)32-22-35-20(18-2-1-3-19(33-18)24(28,29)30)34-21(36-22)31-16-8-9-23(26,27)12-16/h1-7,14,16-17H,8-12H2,(H2,31,32,34,35,36)/t14-,16?,17-	MVZVTAYGMMCXIJ-CRKQFFBESA-N	280077	US10028961, Compound 230::US10172864, Compound 230::US10946023, Compound 230	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280077	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280077&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817184	378161627							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533094	CC(C)(CC#N)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C21H19F5N8/c1-19(2,8-9-27)34-18-32-16(13-5-4-6-14(30-13)21(24,25)26)31-17(33-18)29-12-7-10-28-15(11-12)20(3,22)23/h4-7,10-11H,8H2,1-3H3,(H2,28,29,31,32,33,34)	BFTBMPMZGISYIU-UHFFFAOYSA-N	280078	US10028961, Compound 231::US10172864, Compound 231::US10946023, Compound 231	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280078	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280078&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117800590	378161628							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533099	FC(F)(F)CNc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C17H10F9N7/c18-15(19,20)7-28-13-31-12(9-2-1-3-10(30-9)16(21,22)23)32-14(33-13)29-8-4-5-27-11(6-8)17(24,25)26/h1-6H,7H2,(H2,27,28,29,31,32,33)	PLCJHAPDBYLXRZ-UHFFFAOYSA-N	280079	US10028961, Compound 232::US10172864, Compound 232::US10946023, Compound 232	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280079	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280079&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817637	378161629							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533103	COCCC(C)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H25F3N6O/c1-11(9-10-29-3)23-17-26-16(14-5-4-6-15(25-14)19(20,21)22)27-18(28-17)24-12(2)13-7-8-13/h4-6,11-13H,7-10H2,1-3H3,(H2,23,24,26,27,28)/t11?,12-/m1/s1	VFXTUCQMLFRPEW-PIJUOVFKSA-N	280080	US10028961, Compound 233::US10172864, Compound 233::US10946023, Compound 233	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280080	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280080&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817167	378161630							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533104	C[C@@H](Nc1nc(NC2C3CC4CC(C3)CC2C4)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C24H29F3N6/c1-12(15-5-6-15)28-22-31-21(18-3-2-4-19(29-18)24(25,26)27)32-23(33-22)30-20-16-8-13-7-14(10-16)11-17(20)9-13/h2-4,12-17,20H,5-11H2,1H3,(H2,28,30,31,32,33)/t12-,13?,14?,16?,17?,20?/m1/s1	IQUHQOIQGCZYCW-FGSOGITGSA-N	280081	US10028961, Compound 234::US10172864, Compound 234::US10946023, Compound 234	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280081	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280081&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			122440897	378161631							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533105	CC(C)(O)CNc1nc(Nc2cc(F)cc(F)c2)nc(n1)-n1ccc(n1)C(F)(F)F	InChI=1S/C17H16F5N7O/c1-16(2,30)8-23-13-25-14(24-11-6-9(18)5-10(19)7-11)27-15(26-13)29-4-3-12(28-29)17(20,21)22/h3-7,30H,8H2,1-2H3,(H2,23,24,25,26,27)	WNTKHAXLAGBPKP-UHFFFAOYSA-N	280082	US10028961, Compound 235::US10172864, Compound 235::US10946023, Compound 235	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280082	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280082&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799168	378161632							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533109	CC(C)(O)CNc1nc(Nc2cc(F)cc(Cl)c2)nc(n1)-c1cccc(n1)C(C)(F)F	InChI=1S/C20H20ClF3N6O/c1-19(2,31)10-25-17-28-16(14-5-4-6-15(27-14)20(3,23)24)29-18(30-17)26-13-8-11(21)7-12(22)9-13/h4-9,31H,10H2,1-3H3,(H2,25,26,28,29,30)	OCYNITMCPHUSLK-UHFFFAOYSA-N	280083	US10028961, Compound 236::US10172864, Compound 236::US10946023, Compound 236	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280083	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280083&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817133	378161633							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533113	FC(F)(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H18F7N7/c19-16(20)4-1-9(7-16)27-14-30-13(12-26-6-3-11(29-12)18(23,24)25)31-15(32-14)28-10-2-5-17(21,22)8-10/h3,6,9-10H,1-2,4-5,7-8H2,(H2,27,28,30,31,32)	KWUXKJRKEMYSCZ-UHFFFAOYSA-N	280084	US10028961, Compound 237::US10172864, Compound 237::US10946023, Compound 237	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280084	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280084&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817165	378161634							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533118	FC(F)(F)c1cccc(n1)-c1nc(NC2CN(C2)c2ccccn2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C22H21F5N8/c23-21(24)8-7-13(10-21)29-19-32-18(15-4-3-5-16(31-15)22(25,26)27)33-20(34-19)30-14-11-35(12-14)17-6-1-2-9-28-17/h1-6,9,13-14H,7-8,10-12H2,(H2,29,30,32,33,34)	ZBGLZSWJEQJJBZ-UHFFFAOYSA-N	280085	US10028961, Compound 238::US10172864, Compound 238::US10946023, Compound 238	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280085	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280085&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817186	378161635							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533120	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(N[C@@H]2CN(C(=O)C2)c2ccccn2)n1	InChI=1S/C23H21F5N8O/c24-22(25)8-7-13(11-22)30-20-33-19(15-4-3-5-16(32-15)23(26,27)28)34-21(35-20)31-14-10-18(37)36(12-14)17-6-1-2-9-29-17/h1-6,9,13-14H,7-8,10-12H2,(H2,30,31,33,34,35)/t13?,14-/m0/s1	JXQUUPVCXHTUAY-KZUDCZAMSA-N	280086	US10028961, Compound 239::US10172864, Compound 239::US10946023, Compound 239	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280086	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280086&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817437	378161636							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533122	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(C=C)n1)C1CC1	InChI=1S/C20H26N6/c1-4-16-6-5-7-17(23-16)18-24-19(21-12(2)14-8-9-14)26-20(25-18)22-13(3)15-10-11-15/h4-7,12-15H,1,8-11H2,2-3H3,(H2,21,22,24,25,26)/t12-,13-/m1/s1	OYMZLJQIWORYFQ-CHWSQXEVSA-N	280087	US10028961, Compound 240::US10172864, Compound 240::US10946023, Compound 240	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280087	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280087&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466127	378161637							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533123	CC(C)OCC(C)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H27F3N6O/c1-11(2)30-10-12(3)24-18-27-17(15-6-5-7-16(26-15)20(21,22)23)28-19(29-18)25-13(4)14-8-9-14/h5-7,11-14H,8-10H2,1-4H3,(H2,24,25,27,28,29)/t12?,13-/m1/s1	HNZFJEZPGBZOCO-ZGTCLIOFSA-N	280088	US10028961, Compound 241::US10172864, Compound 241::US10946023, Compound 241	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280088	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280088&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817568	378161638							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533125	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccc(cc3C2)C#N)n1	InChI=1S/C24H20F5N7/c25-23(26)7-6-16(11-23)31-21-34-20(18-2-1-3-19(33-18)24(27,28)29)35-22(36-21)32-17-9-14-5-4-13(12-30)8-15(14)10-17/h1-5,8,16-17H,6-7,9-11H2,(H2,31,32,34,35,36)	TXAOJZZVXLZXJJ-UHFFFAOYSA-N	280089	US10028961, Compound 242::US10172864, Compound 242::US10946023, Compound 242	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280089	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280089&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817436	378161639							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533127	FC(F)(F)c1cccc(n1)-c1nc(NC2CN(C2)c2cccnc2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C22H21F5N8/c23-21(24)7-6-13(9-21)29-19-32-18(16-4-1-5-17(31-16)22(25,26)27)33-20(34-19)30-14-11-35(12-14)15-3-2-8-28-10-15/h1-5,8,10,13-14H,6-7,9,11-12H2,(H2,29,30,32,33,34)	MOFOELJBPOCBKQ-UHFFFAOYSA-N	280090	US10028961, Compound 243::US10172864, Compound 243::US10946023, Compound 243	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280090	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280090&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817396	378161640							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533129	CC(C)(O)CNc1nc(Nc2cc(F)cc(c2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H17F4N7O/c1-19(2,32)10-26-17-29-16(14-4-3-5-15(28-14)20(22,23)24)30-18(31-17)27-13-7-11(9-25)6-12(21)8-13/h3-8,32H,10H2,1-2H3,(H2,26,27,29,30,31)	MVCBBRZTMZDXPK-UHFFFAOYSA-N	280091	US10028961, Compound 244::US10172864, Compound 244::US10946023, Compound 244	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280091	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280091&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798806	378161641							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533134	CC(C)(C)Nc1nc(Nc2cc(F)cc(c2)C#N)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C19H16F4N8/c1-18(2,3)31-17-29-15(14-25-5-4-13(27-14)19(21,22)23)28-16(30-17)26-12-7-10(9-24)6-11(20)8-12/h4-8H,1-3H3,(H2,26,28,29,30,31)	TWTMGQUEQUWIKR-UHFFFAOYSA-N	280092	US10028961, Compound 245::US10172864, Compound 245::US10946023, Compound 245	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280092	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280092&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817542	378161642							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533138	C[C@@H](Nc1nc(NCCOc2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C22H23F3N6O/c1-14(15-10-11-15)27-21-30-19(17-8-5-9-18(28-17)22(23,24)25)29-20(31-21)26-12-13-32-16-6-3-2-4-7-16/h2-9,14-15H,10-13H2,1H3,(H2,26,27,29,30,31)/t14-/m1/s1	YVNVAIVKELSNHE-CQSZACIVSA-N	280093	US10028961, Compound 246::US10172864, Compound 246::US10946023, Compound 246	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280093	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280093&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817294	378161643							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533142	CC(C)(Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C20H17F5N8/c1-18(2,10-26)33-17-31-15(12-5-4-6-13(29-12)20(23,24)25)30-16(32-17)28-11-7-8-27-14(9-11)19(3,21)22/h4-9H,1-3H3,(H2,27,28,30,31,32,33)	BDJHMJRZDMMMSY-UHFFFAOYSA-N	280094	US10028961, Compound 247::US10172864, Compound 247::US10946023, Compound 247	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280094	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280094&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799111	378161644							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533146	CC(C)(O)CNc1nc(Nc2cccc(Cl)c2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H18ClF3N6O/c1-18(2,30)10-24-16-27-15(13-7-4-8-14(26-13)19(21,22)23)28-17(29-16)25-12-6-3-5-11(20)9-12/h3-9,30H,10H2,1-2H3,(H2,24,25,27,28,29)	NRKSVSMTVTZXKR-UHFFFAOYSA-N	280095	US10028961, Compound 248::US10172864, Compound 248::US10946023, Compound 248	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280095	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280095&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817492	378161645							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533150	Nc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H24F5N7/c21-13-1-2-14(26)29-15(13)16-30-17(27-11-3-7-19(22,23)8-4-11)32-18(31-16)28-12-5-9-20(24,25)10-6-12/h1-2,11-12H,3-10H2,(H2,26,29)(H2,27,28,30,31,32)	AHCWVZUQCYWTLX-UHFFFAOYSA-N	280096	US10028961, Compound 249::US10172864, Compound 249::US10946023, Compound 249	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280096	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280096&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799328	378161646							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533154	CC(CC#N)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H17F5N8/c1-11(6-8-26)28-17-31-16(13-4-3-5-14(30-13)20(23,24)25)32-18(33-17)29-12-7-9-27-15(10-12)19(2,21)22/h3-5,7,9-11H,6H2,1-2H3,(H2,27,28,29,31,32,33)	KFKFZAMDAKZTOH-UHFFFAOYSA-N	280097	US10028961, Compound 250::US10172864, Compound 250::US10946023, Compound 250	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280097	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280097&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117800753	378161647							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533158	FC(F)(F)c1nccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H14F7N7/c17-14(18)3-7(4-14)25-12-28-10(9-1-2-24-11(27-9)16(21,22)23)29-13(30-12)26-8-5-15(19,20)6-8/h1-2,7-8H,3-6H2,(H2,25,26,28,29,30)	YXRZGIVPZUGDBI-UHFFFAOYSA-N	280098	US10028961, Compound 251::US10172864, Compound 251::US10946023, Compound 251	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280098	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280098&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817045	378161648							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533162	FC(F)(F)Oc1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C19H19F7N6O/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)33-19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	MQELCCGCZSQGHW-UHFFFAOYSA-N	280099	US10028961, Compound 252::US10172864, Compound 252::US10946023, Compound 252	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280099	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280099&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817037	378161649							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533166	CC(Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C19H15F5N8/c1-10(9-25)27-16-30-15(12-4-3-5-13(29-12)19(22,23)24)31-17(32-16)28-11-6-7-26-14(8-11)18(2,20)21/h3-8,10H,1-2H3,(H2,26,27,28,30,31,32)	DOYNKYWVGHFSIP-UHFFFAOYSA-N	280100	US10028961, Compound 253::US10172864, Compound 253::US10946023, Compound 253	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280100	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280100&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799196	378161650							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533170	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3cc(Br)cc(Br)c3C2)n1	InChI=1S/C23H19Br2F5N6/c24-12-6-11-7-14(9-15(11)16(25)8-12)32-21-35-19(17-2-1-3-18(33-17)23(28,29)30)34-20(36-21)31-13-4-5-22(26,27)10-13/h1-3,6,8,13-14H,4-5,7,9-10H2,(H2,31,32,34,35,36)	OLURZMKGUXLJTI-UHFFFAOYSA-N	280101	US10028961, Compound 254::US10172864, Compound 254::US10946023, Compound 254	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280101	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280101&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817035	378161651							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533171	FC(F)(F)c1cccc(n1)-c1nc(NC2CCOCC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H23F5N6O/c21-19(22)8-4-12(5-9-19)26-17-29-16(14-2-1-3-15(28-14)20(23,24)25)30-18(31-17)27-13-6-10-32-11-7-13/h1-3,12-13H,4-11H2,(H2,26,27,29,30,31)	XOGJBAWBFBEDJT-UHFFFAOYSA-N	280102	US10028961, Compound 255::US10172864, Compound 255::US10946023, Compound 255	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280102	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280102&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817036	378161652							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533174	FC(F)(F)c1ccnc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H14F7N7/c17-14(18)3-7(4-14)25-12-28-11(10-24-2-1-9(27-10)16(21,22)23)29-13(30-12)26-8-5-15(19,20)6-8/h1-2,7-8H,3-6H2,(H2,25,26,28,29,30)	FPHDGFLOXFTVGJ-UHFFFAOYSA-N	280103	US10028961, Compound 256::US10172864, Compound 256::US10946023, Compound 256	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280103	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280103&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817034	378161653							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533178	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C22H17F8N7/c23-20(24)9-19(10-20)7-12(8-19)33-18-36-16(13-2-1-3-14(34-13)21(25,26)27)35-17(37-18)32-11-4-5-31-15(6-11)22(28,29)30/h1-6,12H,7-10H2,(H2,31,32,33,35,36,37)	BTPLBROFKCBOEI-UHFFFAOYSA-N	280104	US10028961, Compound 257::US10172864, Compound 257::US10946023, Compound 257	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280104	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280104&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799484	378161654							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533182	FC1(F)CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C1CC1	InChI=1S/C21H24F4N6/c22-20(23)8-6-13(10-20)26-18-29-17(16-3-1-2-15(28-16)12-4-5-12)30-19(31-18)27-14-7-9-21(24,25)11-14/h1-3,12-14H,4-11H2,(H2,26,27,29,30,31)	KKFMWMMEDKZDHR-UHFFFAOYSA-N	280105	US10028961, Compound 258::US10172864, Compound 258::US10946023, Compound 258	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280105	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280105&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817039	378161655							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533185	CC(C)(O)CNc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C22H21F3N8O/c1-20(2,34)12-28-18-31-17(14-4-3-5-15(30-14)22(23,24)25)32-19(33-18)29-13-6-9-27-16(10-13)21(11-26)7-8-21/h3-6,9-10,34H,7-8,12H2,1-2H3,(H2,27,28,29,31,32,33)	VVOQXSMDMBLJHJ-UHFFFAOYSA-N	280106	US10028961, Compound 259::US10172864, Compound 259::US10946023, Compound 259	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280106	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280106&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798959	378161656							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533188	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)CC3)nc(n2)-c2nc(F)ccc2F)c1	InChI=1S/C20H16F6N6/c21-10-7-11(22)9-13(8-10)28-19-31-17(16-14(23)1-2-15(24)29-16)30-18(32-19)27-12-3-5-20(25,26)6-4-12/h1-2,7-9,12H,3-6H2,(H2,27,28,30,31,32)	KQPYGTOTVLIIEB-UHFFFAOYSA-N	280107	US10028961, Compound 260::US10172864, Compound 260::US10946023, Compound 260	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280107	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280107&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817161	378161657							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533193	FC(F)(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C22H18F5N9/c23-21(24)4-1-13(10-21)32-19-35-17(16-30-8-3-14(33-16)22(25,26)27)34-18(36-19)31-12-2-7-29-15(9-12)20(11-28)5-6-20/h2-3,7-9,13H,1,4-6,10H2,(H2,29,31,32,34,35,36)	NQLUCGNQWCNNAV-UHFFFAOYSA-N	280108	US10028961, Compound 261::US10172864, Compound 261::US10946023, Compound 261	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280108	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280108&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799322	378161658							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533197	C[C@@H](Nc1nc(NCC(C)(C)C#N)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C19H22F3N7/c1-11(12-7-8-12)25-17-28-15(13-5-4-6-14(26-13)19(20,21)22)27-16(29-17)24-10-18(2,3)9-23/h4-6,11-12H,7-8,10H2,1-3H3,(H2,24,25,27,28,29)/t11-/m1/s1	YMYMOIAVHSSRHV-LLVKDONJSA-N	280109	US10028961, Compound 262::US10172864, Compound 262::US10946023, Compound 262	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280109	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280109&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817189	378161659							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533199	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)C(=O)c2ccccc2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C25H24F5N7O/c26-24(27)11-9-16(13-24)31-22-34-20(18-7-4-8-19(33-18)25(28,29)30)35-23(36-22)32-17-10-12-37(14-17)21(38)15-5-2-1-3-6-15/h1-8,16-17H,9-14H2,(H2,31,32,34,35,36)	IGICKZPCOKPPMZ-UHFFFAOYSA-N	280110	US10028961, Compound 263::US10172864, Compound 263::US10946023, Compound 263	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280110	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280110&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817170	378161660							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533202	CC(C)(O)CNc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C18H21F5N6O/c1-16(2,30)9-24-14-27-13(11-4-3-5-12(26-11)18(21,22)23)28-15(29-14)25-10-6-7-17(19,20)8-10/h3-5,10,30H,6-9H2,1-2H3,(H2,24,25,27,28,29)	BBXPSOCEABWQQG-UHFFFAOYSA-N	280111	US10028961, Compound 264::US10172864, Compound 264::US10946023, Compound 264	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280111	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280111&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817169	378161661							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533204	FC1(F)CC2(CC(C2)Nc2nc(NC3CC4(C3)CC(F)(F)C4)nc(n2)-c2cccc(Cl)n2)C1	InChI=1S/C22H23ClF4N6/c23-15-3-1-2-14(30-15)16-31-17(28-12-4-19(5-12)8-21(24,25)9-19)33-18(32-16)29-13-6-20(7-13)10-22(26,27)11-20/h1-3,12-13H,4-11H2,(H2,28,29,31,32,33)	PBFHHOMGSNGWEC-UHFFFAOYSA-N	280112	US10028961, Compound 265::US10172864, Compound 265::US10946023, Compound 265	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280112	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280112&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817162	378161662							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533206	CS(=O)(=O)N1CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C21H26F5N7O2S/c1-36(34,35)33-11-7-14(8-12-33)28-19-31-17(15-3-2-4-16(29-15)21(24,25)26)30-18(32-19)27-13-5-9-20(22,23)10-6-13/h2-4,13-14H,5-12H2,1H3,(H2,27,28,30,31,32)	XMCNRFYMKPJZQG-UHFFFAOYSA-N	280113	US10028961, Compound 266::US10172864, Compound 266::US10946023, Compound 266	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280113	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280113&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817164	378161663							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533209	CC(C)(CNc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C21H19F5N8/c1-19(2,10-27)11-29-17-32-16(13-5-4-6-14(31-13)21(24,25)26)33-18(34-17)30-12-7-8-28-15(9-12)20(3,22)23/h4-9H,11H2,1-3H3,(H2,28,29,30,32,33,34)	LWUOICMGVABMMB-UHFFFAOYSA-N	280114	US10028961, Compound 267::US10172864, Compound 267::US10946023, Compound 267	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280114	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280114&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117800203	378161664							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533213	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1nccc(n1)C(F)(F)F)C1CC1	InChI=1S/C18H22F3N7/c1-9(11-3-4-11)23-16-26-15(14-22-8-7-13(25-14)18(19,20)21)27-17(28-16)24-10(2)12-5-6-12/h7-12H,3-6H2,1-2H3,(H2,23,24,26,27,28)/t9-,10-/m1/s1	DDVPWDBXRXZEBC-NXEZZACHSA-N	280115	US10028961, Compound 268::US10172864, Compound 268::US10946023, Compound 268	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280115	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280115&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817172	378161665							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533218	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C#N)C1CC1	InChI=1S/C19H23N7/c1-11(13-6-7-13)21-18-24-17(16-5-3-4-15(10-20)23-16)25-19(26-18)22-12(2)14-8-9-14/h3-5,11-14H,6-9H2,1-2H3,(H2,21,22,24,25,26)/t11-,12-/m1/s1	BOOMYPYTFNGPNE-VXGBXAGGSA-N	280116	US10028961, Compound 269::US10172864, Compound 269::US10946023, Compound 269	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280116	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280116&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466128	378161666							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533219	FC(F)(F)c1nccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F7N7/c21-18(22)6-1-11(2-7-18)29-16-32-14(13-5-10-28-15(31-13)20(25,26)27)33-17(34-16)30-12-3-8-19(23,24)9-4-12/h5,10-12H,1-4,6-9H2,(H2,29,30,32,33,34)	VFDBHGHEXPAMBP-UHFFFAOYSA-N	280117	US10028961, Compound 270::US10172864, Compound 270::US10946023, Compound 270	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280117	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280117&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817589	378161667							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533223	CC(CC#N)Nc1nc(NC(C)C[N+]#[C-])nc(n1)-c1cccc(Cl)n1	InChI=1S/C16H17ClN8/c1-10(7-8-18)20-15-23-14(12-5-4-6-13(17)22-12)24-16(25-15)21-11(2)9-19-3/h4-6,10-11H,7,9H2,1-2H3,(H2,20,21,23,24,25)	DPKMJIDGQOHGGQ-UHFFFAOYSA-N	280118	US10028961, Compound 271::US10172864, Compound 271	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280118	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280118&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124023000	378161668							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533225	Fc1ccc(cc1)[C@@H]1C[C@@H](C1)Nc1nc(N[C@H]2C[C@H](C2)c2ccc(F)cc2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C29H25F5N6/c30-20-8-4-16(5-9-20)18-12-22(13-18)35-27-38-26(24-2-1-3-25(37-24)29(32,33)34)39-28(40-27)36-23-14-19(15-23)17-6-10-21(31)11-7-17/h1-11,18-19,22-23H,12-15H2,(H2,35,36,38,39,40)/t18-,19-,22+,23+	NMLSZZYWTRQLTB-MBEIMAIZSA-N	280119	US10028961, Compound 272::US10172864, Compound 272::US10946023, Compound 272	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280119	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280119&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817318	378161669							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533230	CC(=O)N1CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C22H26F5N7O/c1-13(35)34-11-7-15(8-12-34)29-20-32-18(16-3-2-4-17(30-16)22(25,26)27)31-19(33-20)28-14-5-9-21(23,24)10-6-14/h2-4,14-15H,5-12H2,1H3,(H2,28,29,31,32,33)	PVZIUYNREPTYEJ-UHFFFAOYSA-N	280120	US10028961, Compound 273::US10172864, Compound 273::US10946023, Compound 273	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280120	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280120&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817549	378161670							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533233	CC(C)(C)OC(=O)N1CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C25H32F5N7O2/c1-23(2,3)39-22(38)37-13-9-16(10-14-37)32-21-35-19(17-5-4-6-18(33-17)25(28,29)30)34-20(36-21)31-15-7-11-24(26,27)12-8-15/h4-6,15-16H,7-14H2,1-3H3,(H2,31,32,34,35,36)	MMAPFCIIBGUZQG-UHFFFAOYSA-N	280121	US10028961, Compound 274::US10172864, Compound 274::US10946023, Compound 274	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280121	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280121&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817557	378161671							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533235	Cn1cc(c(n1)C(F)(F)F)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H24F7N7/c1-34-10-13(14(33-34)20(25,26)27)15-30-16(28-11-2-6-18(21,22)7-3-11)32-17(31-15)29-12-4-8-19(23,24)9-5-12/h10-12H,2-9H2,1H3,(H2,28,29,30,31,32)	MZFAUIFIADPAFR-UHFFFAOYSA-N	280122	US10028961, Compound 275::US10172864, Compound 275::US10946023, Compound 275	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280122	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280122&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817548	378161672							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533236	Fc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F6N6/c21-13-1-2-14(22)29-15(13)16-30-17(27-11-3-7-19(23,24)8-4-11)32-18(31-16)28-12-5-9-20(25,26)10-6-12/h1-2,11-12H,3-10H2,(H2,27,28,30,31,32)	PKVKJUWOHXPGCE-UHFFFAOYSA-N	280123	US10028961, Compound 276::US10172864, Compound 276::US10946023, Compound 276	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280123	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280123&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799150	378161673							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533238	FC(F)(F)Oc1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C17H15F7N6O/c18-15(19)4-8(5-15)25-13-28-12(10-2-1-3-11(27-10)31-17(22,23)24)29-14(30-13)26-9-6-16(20,21)7-9/h1-3,8-9H,4-7H2,(H2,25,26,28,29,30)	KBOZWPPHVTYNOC-UHFFFAOYSA-N	280124	US10028961, Compound 277::US10172864, Compound 277::US10946023, Compound 277	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280124	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280124&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817028	378161674							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533241	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cncc(Cl)c1)C1CC1	InChI=1S/C18H23ClN6/c1-10(12-3-4-12)21-17-23-16(14-7-15(19)9-20-8-14)24-18(25-17)22-11(2)13-5-6-13/h7-13H,3-6H2,1-2H3,(H2,21,22,23,24,25)/t10-,11-/m1/s1	KKRJUHWKVGWXTJ-GHMZBOCLSA-N	280125	US10028961, Compound 278::US10172864, Compound 278::US10946023, Compound 278	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280125	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280125&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817585	378161675							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533244	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-n1cc(I)cn1)C1CC1	InChI=1S/C16H22IN7/c1-9(11-3-4-11)19-14-21-15(20-10(2)12-5-6-12)23-16(22-14)24-8-13(17)7-18-24/h7-12H,3-6H2,1-2H3,(H2,19,20,21,22,23)/t9-,10-/m1/s1	XKHRDUPMIXLGTD-NXEZZACHSA-N	280126	US10028961, Compound 279::US10172864, Compound 279::US10946023, Compound 279	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280126	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280126&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817477	378161676							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533248	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(Cc3ccccc3)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C25H26F5N7/c26-24(27)11-9-17(13-24)31-22-34-21(19-7-4-8-20(33-19)25(28,29)30)35-23(36-22)32-18-10-12-37(15-18)14-16-5-2-1-3-6-16/h1-8,17-18H,9-15H2,(H2,31,32,34,35,36)	UWVLIFBOSBPFON-UHFFFAOYSA-N	280127	US10028961, Compound 280::US10172864, Compound 280::US10946023, Compound 280	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280127	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280127&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817414	378161677							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533251	C[C@H](CO)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C17H21F3N6O/c1-9(8-27)21-15-24-14(12-4-3-5-13(23-12)17(18,19)20)25-16(26-15)22-10(2)11-6-7-11/h3-5,9-11,27H,6-8H2,1-2H3,(H2,21,22,24,25,26)/t9-,10-/m1/s1	RFBMTEMJWRNYFW-NXEZZACHSA-N	280128	US10028961, Compound 281::US10172864, Compound 281::US10946023, Compound 281	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280128	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280128&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817475	378161678							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533252	Cc1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H26F4N6/c1-13-3-2-4-16(26-13)17-29-18(27-14-5-9-20(22,23)10-6-14)31-19(30-17)28-15-7-11-21(24,25)12-8-15/h2-4,14-15H,5-12H2,1H3,(H2,27,28,29,30,31)	YBYIINHMDQHRAL-UHFFFAOYSA-N	280129	US10028961, Compound 282::US10172864, Compound 282::US10946023, Compound 282	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280129	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280129&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817481	378161679							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533253	CC(F)(F)c1nc(cs1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H24F6N6S/c1-18(21,22)15-29-13(10-33-15)14-30-16(27-11-2-6-19(23,24)7-3-11)32-17(31-14)28-12-4-8-20(25,26)9-5-12/h10-12H,2-9H2,1H3,(H2,27,28,30,31,32)	BCVWBQGSHAGBJM-UHFFFAOYSA-N	280130	US10028961, Compound 283::US10172864, Compound 283::US10946023, Compound 283	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280130	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280130&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817484	378161680							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533256	C[C@@H](Nc1nc(NCC#C)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C17H17F3N6/c1-3-9-21-15-24-14(12-5-4-6-13(23-12)17(18,19)20)25-16(26-15)22-10(2)11-7-8-11/h1,4-6,10-11H,7-9H2,2H3,(H2,21,22,24,25,26)/t10-/m1/s1	NAAKTSUJFNNEGV-SNVBAGLBSA-N	280131	US10028961, Compound 284::US10172864, Compound 284::US10946023, Compound 284	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280131	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280131&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817478	378161681							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533257	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(N)n1)C1CC1	InChI=1S/C18H25N7/c1-10(12-6-7-12)20-17-23-16(14-4-3-5-15(19)22-14)24-18(25-17)21-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,19,22)(H2,20,21,23,24,25)/t10-,11-/m1/s1	PRARPIBZHWEZPY-GHMZBOCLSA-N	280132	US10028961, Compound 285::US10172864, Compound 285::US10946023, Compound 285	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280132	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280132&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817474	378161682							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533260	COC(=O)CCNc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C18H21F3N6O2/c1-10(11-6-7-11)23-17-26-15(12-4-3-5-13(24-12)18(19,20)21)25-16(27-17)22-9-8-14(28)29-2/h3-5,10-11H,6-9H2,1-2H3,(H2,22,23,25,26,27)/t10-/m1/s1	KELFRTMXGNRFFX-SNVBAGLBSA-N	280133	US10028961, Compound 286::US10172864, Compound 286::US10946023, Compound 286	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280133	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280133&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817479	378161683							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533261	CC(C)(O)CNc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H23F5N6O/c1-17(2,31)10-25-15-28-14(12-4-3-5-13(27-12)19(22,23)24)29-16(30-15)26-11-6-8-18(20,21)9-7-11/h3-5,11,31H,6-10H2,1-2H3,(H2,25,26,28,29,30)	IWJRYKAPBRKGLL-UHFFFAOYSA-N	280134	US10028961, Compound 287::US10172864, Compound 287::US10946023, Compound 287	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280134	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280134&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817444	378161684							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533265	CC(C)(O)CNc1nc(Nc2ccnc(c2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H17F3N8O/c1-18(2,31)10-25-16-28-15(13-4-3-5-14(27-13)19(20,21)22)29-17(30-16)26-11-6-7-24-12(8-11)9-23/h3-8,31H,10H2,1-2H3,(H2,24,25,26,28,29,30)	VHJMSJJKVRIIBP-UHFFFAOYSA-N	280135	US10028961, Compound 288::US10172864, Compound 288	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280135	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280135&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799170	378161685							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533268	CC(C)(C)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C19H19F5N8/c1-17(2,3)32-16-30-14(13-26-8-6-11(28-13)19(22,23)24)29-15(31-16)27-10-5-7-25-12(9-10)18(4,20)21/h5-9H,1-4H3,(H2,25,27,29,30,31,32)	VVDJVXUCSQFDNF-UHFFFAOYSA-N	280136	US10028961, Compound 289::US10172864, Compound 289::US10946023, Compound 289	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280136	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280136&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817459	378161686							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533272	OC1CCCC1Nc1nc(NC2CCCC2O)nc(n1)-c1cccc(Cl)n1	InChI=1S/C18H23ClN6O2/c19-15-9-3-6-12(20-15)16-23-17(21-10-4-1-7-13(10)26)25-18(24-16)22-11-5-2-8-14(11)27/h3,6,9-11,13-14,26-27H,1-2,4-5,7-8H2,(H2,21,22,23,24,25)	FIFASAIIXLNWSD-UHFFFAOYSA-N	280137	US10028961, Compound 290::US10172864, Compound 290::US10946023, Compound 290	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280137	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280137&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817457	378161687							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533273	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2cc3ccccc3[nH]2)n1	InChI=1S/C22H18F5N7/c23-21(24)9-8-13(11-21)28-19-32-18(15-6-3-7-16(29-15)22(25,26)27)33-20(34-19)31-17-10-12-4-1-2-5-14(12)30-17/h1-7,10,13,30H,8-9,11H2,(H2,28,31,32,33,34)	JUXFFUXEYZBADD-UHFFFAOYSA-N	280138	US10028961, Compound 291::US10172864, Compound 291::US10946023, Compound 291	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550					6.5000	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280138	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280138&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817461	378161688							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533274	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cc(F)ccc1F)C1CC1	InChI=1S/C19H23F2N5/c1-10(12-3-4-12)22-18-24-17(15-9-14(20)7-8-16(15)21)25-19(26-18)23-11(2)13-5-6-13/h7-13H,3-6H2,1-2H3,(H2,22,23,24,25,26)/t10-,11-/m1/s1	OFWGSSJSAWQKRK-GHMZBOCLSA-N	280139	US10028961, Compound 292::US10172864, Compound 292::US10946023, Compound 292	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280139	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280139&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817456	378161689							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533276	FC(F)(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F7N7/c21-18(22)6-1-11(2-7-18)29-16-32-15(14-28-10-5-13(31-14)20(25,26)27)33-17(34-16)30-12-3-8-19(23,24)9-4-12/h5,10-12H,1-4,6-9H2,(H2,29,30,32,33,34)	MDCZNBIZILVZSF-UHFFFAOYSA-N	280140	US10028961, Compound 293::US10172864, Compound 293::US10946023, Compound 293	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280140	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280140&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817463	378161690							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533280	COc1cccc(n1)-c1nc(N[C@H](C)C2CC2)nc(N[C@H](C)C2CC2)n1	InChI=1S/C19H26N6O/c1-11(13-7-8-13)20-18-23-17(15-5-4-6-16(22-15)26-3)24-19(25-18)21-12(2)14-9-10-14/h4-6,11-14H,7-10H2,1-3H3,(H2,20,21,23,24,25)/t11-,12-/m1/s1	WYXMPHFGDDGKSR-VXGBXAGGSA-N	280141	US10028961, Compound 294::US10172864, Compound 294::US10946023, Compound 294	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280141	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280141&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817460	378161691							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533281	COCCOCC(C)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H27F3N6O2/c1-12(11-31-10-9-30-3)24-18-27-17(15-5-4-6-16(26-15)20(21,22)23)28-19(29-18)25-13(2)14-7-8-14/h4-6,12-14H,7-11H2,1-3H3,(H2,24,25,27,28,29)/t12?,13-/m1/s1	OAYRAJOVHMVYGP-ZGTCLIOFSA-N	280142	US10028961, Compound 295::US10172864, Compound 295::US10946023, Compound 295	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280142	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280142&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799237	378161692							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533282	FC(F)(F)Oc1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H23F7N6O/c22-19(23)8-4-12(5-9-19)29-17-32-16(14-2-1-3-15(31-14)35-21(26,27)28)33-18(34-17)30-13-6-10-20(24,25)11-7-13/h1-3,12-13H,4-11H2,(H2,29,30,32,33,34)	HSAOXCHGPDCXKT-UHFFFAOYSA-N	280143	US10028961, Compound 296::US10172864, Compound 296::US10946023, Compound 296	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280143	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280143&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817462	378161693							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533284	FC(F)(F)c1n[nH]cc1-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H22F7N7/c20-17(21)5-1-10(2-6-17)28-15-30-14(12-9-27-33-13(12)19(24,25)26)31-16(32-15)29-11-3-7-18(22,23)8-4-11/h9-11H,1-8H2,(H,27,33)(H2,28,29,30,31,32)	WYHVNJNVMROQBY-UHFFFAOYSA-N	280144	US10028961, Compound 297::US10172864, Compound 297::US10946023, Compound 297	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280144	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280144&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817464	378161694							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533286	CC(C)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C18H17F5N8/c1-9(2)26-15-29-14(13-25-7-5-11(28-13)18(21,22)23)30-16(31-15)27-10-4-6-24-12(8-10)17(3,19)20/h4-9H,1-3H3,(H2,24,26,27,29,30,31)	MNWAUMZTPYXVGO-UHFFFAOYSA-N	280145	US10028961, Compound 298::US10172864, Compound 298::US10946023, Compound 298	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280145	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280145&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798710	378161695							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533290	Fc1ccc(cc1)[C@H]1C[C@@H](C1)Nc1nc(N[C@H]2C[C@@H](C2)c2ccc(F)cc2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C29H25F5N6/c30-20-8-4-16(5-9-20)18-12-22(13-18)35-27-38-26(24-2-1-3-25(37-24)29(32,33)34)39-28(40-27)36-23-14-19(15-23)17-6-10-21(31)11-7-17/h1-11,18-19,22-23H,12-15H2,(H2,35,36,38,39,40)/t18-,19-,22-,23-	NMLSZZYWTRQLTB-YKFMMLSNSA-N	280146	US10028961, Compound 299::US10172864, Compound 299::US10946023, Compound 299	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280146	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280146&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817318	378161696							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533291	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cncc(c1)C(F)(F)F)C1CC1	InChI=1S/C19H23F3N6/c1-10(12-3-4-12)24-17-26-16(14-7-15(9-23-8-14)19(20,21)22)27-18(28-17)25-11(2)13-5-6-13/h7-13H,3-6H2,1-2H3,(H2,24,25,26,27,28)/t10-,11-/m1/s1	ALVRRVSCSVEIIK-GHMZBOCLSA-N	280147	US10028961, Compound 300::US10172864, Compound 300::US10946023, Compound 300	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280147	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280147&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817346	378161697							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533292	Cc1nc(co1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H16F4N6O/c1-7-20-10(6-26-7)11-23-12(21-8-2-14(16,17)3-8)25-13(24-11)22-9-4-15(18,19)5-9/h6,8-9H,2-5H2,1H3,(H2,21,22,23,24,25)	YBHPSBQYBQRDEV-UHFFFAOYSA-N	280148	US10028961, Compound 301::US10172864, Compound 301::US10946023, Compound 301	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280148	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280148&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817319	378161698							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533294	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-n1cc(Cl)cn1	InChI=1S/C18H22ClF4N7/c19-11-9-24-30(10-11)16-28-14(25-12-1-5-17(20,21)6-2-12)27-15(29-16)26-13-3-7-18(22,23)8-4-13/h9-10,12-13H,1-8H2,(H2,25,26,27,28,29)	QSWMJNNVEMLNDB-UHFFFAOYSA-N	280149	US10028961, Compound 302::US10172864, Compound 302::US10946023, Compound 302	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280149	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280149&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817332	378161699							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533298	C[C@@H](Nc1nc(NCC(C)(C)C(N)=O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C19H24F3N7O/c1-10(11-7-8-11)25-17-28-14(12-5-4-6-13(26-12)19(20,21)22)27-16(29-17)24-9-18(2,3)15(23)30/h4-6,10-11H,7-9H2,1-3H3,(H2,23,30)(H2,24,25,27,28,29)/t10-/m1/s1	XTYWTUUCWNFNQP-SNVBAGLBSA-N	280150	US10028961, Compound 303::US10172864, Compound 303::US10946023, Compound 303	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280150	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280150&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817320	378161700							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533299	Cn1ccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H25F4N7/c1-30-11-6-14(29-30)15-26-16(24-12-2-7-18(20,21)8-3-12)28-17(27-15)25-13-4-9-19(22,23)10-5-13/h6,11-13H,2-5,7-10H2,1H3,(H2,24,25,26,27,28)	QCQLUIVJCWNARE-UHFFFAOYSA-N	280151	US10028961, Compound 304::US10172864, Compound 304::US10946023, Compound 304	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280151	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280151&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817330	378161701							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533300	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C1CC1	InChI=1S/C23H28F4N6/c24-22(25)10-6-15(7-11-22)28-20-31-19(18-3-1-2-17(30-18)14-4-5-14)32-21(33-20)29-16-8-12-23(26,27)13-9-16/h1-3,14-16H,4-13H2,(H2,28,29,31,32,33)	PNHZDKHPDZVPGP-UHFFFAOYSA-N	280152	US10028961, Compound 305::US10172864, Compound 305::US10946023, Compound 305	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280152	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280152&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799070	378161702							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533301	CC(CN1CCOCC1)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C21H28F3N7O/c1-13(12-31-8-10-32-11-9-31)25-19-28-18(16-4-3-5-17(27-16)21(22,23)24)29-20(30-19)26-14(2)15-6-7-15/h3-5,13-15H,6-12H2,1-2H3,(H2,25,26,28,29,30)/t13?,14-/m1/s1	FAGQCPRWPNBUIH-ARLHGKGLSA-N	280153	US10028961, Compound 306::US10172864, Compound 306::US10946023, Compound 306	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280153	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280153&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799015	378161703							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533302	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(N)=O)C1CC1	InChI=1S/C19H25N7O/c1-10(12-6-7-12)21-18-24-17(15-5-3-4-14(23-15)16(20)27)25-19(26-18)22-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,20,27)(H2,21,22,24,25,26)/t10-,11-/m1/s1	ANCUHZOTRVEMID-GHMZBOCLSA-N	280154	US10028961, Compound 307::US10172864, Compound 307::US10946023, Compound 307	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280154	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280154&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799230	378161704							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533303	FC(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H23F6N7/c21-14(22)13-5-10-27-15(30-13)16-31-17(28-11-1-6-19(23,24)7-2-11)33-18(32-16)29-12-3-8-20(25,26)9-4-12/h5,10-12,14H,1-4,6-9H2,(H2,28,29,31,32,33)	KCKMAAKVFCQNEN-UHFFFAOYSA-N	280155	US10028961, Compound 308::US10172864, Compound 308::US10946023, Compound 308	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280155	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280155&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466270	378161705							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533306	Oc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H23F5N6O/c21-13-1-2-14(32)28-15(13)16-29-17(26-11-3-7-19(22,23)8-4-11)31-18(30-16)27-12-5-9-20(24,25)10-6-12/h1-2,11-12H,3-10H2,(H,28,32)(H2,26,27,29,30,31)	LBPUKFIAHANDDC-UHFFFAOYSA-N	280156	US10028961, Compound 309::US10172864, Compound 309::US10946023, Compound 309	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280156	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280156&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799124	378161706							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533307	COC(=O)c1cccc(n1)-c1nc(N[C@H](C)C2CC2)nc(N[C@H](C)C2CC2)n1	InChI=1S/C20H26N6O2/c1-11(13-7-8-13)21-19-24-17(15-5-4-6-16(23-15)18(27)28-3)25-20(26-19)22-12(2)14-9-10-14/h4-6,11-14H,7-10H2,1-3H3,(H2,21,22,24,25,26)/t11-,12-/m1/s1	COOHZFVAXQNVEL-VXGBXAGGSA-N	280157	US10028961, Compound 310::US10172864, Compound 310::US10946023, Compound 310	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280157	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280157&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799400	378161707							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533308	Cc1cc(no1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H16F4N6O/c1-7-2-10(25-26-7)11-22-12(20-8-3-14(16,17)4-8)24-13(23-11)21-9-5-15(18,19)6-9/h2,8-9H,3-6H2,1H3,(H2,20,21,22,23,24)	JWLFPLOMUNYBLN-UHFFFAOYSA-N	280158	US10028961, Compound 311::US10172864, Compound 311::US10946023, Compound 311	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280158	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280158&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817411	378161708							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533310	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-n1cc(C)cn1)C1CC1	InChI=1S/C17H25N7/c1-10-8-18-24(9-10)17-22-15(19-11(2)13-4-5-13)21-16(23-17)20-12(3)14-6-7-14/h8-9,11-14H,4-7H2,1-3H3,(H2,19,20,21,22,23)/t11-,12-/m1/s1	CCTGXGIKECSYLR-VXGBXAGGSA-N	280159	US10028961, Compound 312::US10172864, Compound 312::US10946023, Compound 312	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280159	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280159&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817579	378161709							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533311	Fc1ccc(cc1)N1CC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C23H21F6N7/c24-13-4-6-16(7-5-13)36-11-15(12-36)31-21-34-19(17-2-1-3-18(32-17)23(27,28)29)33-20(35-21)30-14-8-9-22(25,26)10-14/h1-7,14-15H,8-12H2,(H2,30,31,33,34,35)	WKTDNXNWAJZYOL-UHFFFAOYSA-N	280160	US10028961, Compound 313::US10172864, Compound 313::US10946023, Compound 313	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280160	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280160&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817351	378161710							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533312	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cc(Cl)ccn1	InChI=1S/C20H23ClF4N6/c21-12-5-10-26-15(11-12)16-29-17(27-13-1-6-19(22,23)7-2-13)31-18(30-16)28-14-3-8-20(24,25)9-4-14/h5,10-11,13-14H,1-4,6-9H2,(H2,27,28,29,30,31)	LSGOKKOWCOIAGR-UHFFFAOYSA-N	280161	US10028961, Compound 314::US10172864, Compound 314::US10946023, Compound 314	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280161	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280161&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817483	378161711							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533313	COCCc1ccnc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C22H29F4N7O/c1-34-13-7-16-6-12-27-17(28-16)18-31-19(29-14-2-8-21(23,24)9-3-14)33-20(32-18)30-15-4-10-22(25,26)11-5-15/h6,12,14-15H,2-5,7-11,13H2,1H3,(H2,29,30,31,32,33)	IIDRMKULCOPTDM-UHFFFAOYSA-N	280162	US10028961, Compound 315::US10172864, Compound 315::US10946023, Compound 315	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280162	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280162&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466269	378161712							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533314	Cn1c(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)cc2ccccc12	InChI=1S/C23H20F5N7/c1-35-16-7-3-2-5-13(16)11-18(35)31-21-33-19(15-6-4-8-17(30-15)23(26,27)28)32-20(34-21)29-14-9-10-22(24,25)12-14/h2-8,11,14H,9-10,12H2,1H3,(H2,29,31,32,33,34)	LELUQJXOLYUADR-UHFFFAOYSA-N	280163	US10028961, Compound 316::US10172864, Compound 316::US10946023, Compound 316	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280163	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280163&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817449	378161713							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533315	Cc1nc(c[nH]1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H17F4N7/c1-7-20-6-10(21-7)11-24-12(22-8-2-14(16,17)3-8)26-13(25-11)23-9-4-15(18,19)5-9/h6,8-9H,2-5H2,1H3,(H,20,21)(H2,22,23,24,25,26)	LRORKNAAPJYJSX-UHFFFAOYSA-N	280164	US10028961, Compound 317::US10172864, Compound 317::US10946023, Compound 317	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280164	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280164&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817555	378161714							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533316	FC(F)(F)c1ccnc(c1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H23F7N6/c22-19(23)6-1-13(2-7-19)30-17-32-16(15-11-12(5-10-29-15)21(26,27)28)33-18(34-17)31-14-3-8-20(24,25)9-4-14/h5,10-11,13-14H,1-4,6-9H2,(H2,30,31,32,33,34)	CVGPCRWUHFXMHW-UHFFFAOYSA-N	280165	US10028961, Compound 318::US10172864, Compound 318::US10946023, Compound 318	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280165	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280165&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817556	378161715							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533317	Cc1nc(c[nH]1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C17H21F4N7/c1-9-22-8-12(23-9)13-26-14(24-10-2-4-16(18,19)6-10)28-15(27-13)25-11-3-5-17(20,21)7-11/h8,10-11H,2-7H2,1H3,(H,22,23)(H2,24,25,26,27,28)	WXUIXALGZVQUGH-UHFFFAOYSA-N	280166	US10028961, Compound 319::US10172864, Compound 319::US10946023, Compound 319	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000					6.5000	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280166	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280166&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817325	378161716							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533318	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(c1)C#N)C1CC1	InChI=1S/C20H24N6/c1-12(15-6-7-15)22-19-24-18(17-5-3-4-14(10-17)11-21)25-20(26-19)23-13(2)16-8-9-16/h3-5,10,12-13,15-16H,6-9H2,1-2H3,(H2,22,23,24,25,26)/t12-,13-/m1/s1	XAPUEAYQMZYLNW-CHWSQXEVSA-N	280167	US10028961, Compound 320::US10172864, Compound 320::US10946023, Compound 320	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280167	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280167&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817299	378161717							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533319	COc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H25F5N6O/c1-33-15-3-2-14(22)16(29-15)17-30-18(27-12-4-8-20(23,24)9-5-12)32-19(31-17)28-13-6-10-21(25,26)11-7-13/h2-3,12-13H,4-11H2,1H3,(H2,27,28,30,31,32)	PUYRUGBORWDDDV-UHFFFAOYSA-N	280168	US10028961, Compound 321::US10172864, Compound 321::US10946023, Compound 321	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280168	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280168&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817329	378161718							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533321	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(OC(F)(F)F)c1)C1CC1	InChI=1S/C20H24F3N5O/c1-11(13-6-7-13)24-18-26-17(27-19(28-18)25-12(2)14-8-9-14)15-4-3-5-16(10-15)29-20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,26,27,28)/t11-,12-/m1/s1	RTLORKKPLAXBLK-VXGBXAGGSA-N	280169	US10028961, Compound 322::US10172864, Compound 322::US10946023, Compound 322	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280169	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280169&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817309	378161719							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533322	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccnc(c1)C(F)(F)F)C1CC1	InChI=1S/C19H23F3N6/c1-10(12-3-4-12)24-17-26-16(14-7-8-23-15(9-14)19(20,21)22)27-18(28-17)25-11(2)13-5-6-13/h7-13H,3-6H2,1-2H3,(H2,24,25,26,27,28)/t10-,11-/m1/s1	OZTHBVUYLQRNQU-GHMZBOCLSA-N	280170	US10028961, Compound 323::US10172864, Compound 323::US10946023, Compound 323	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280170	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280170&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817302	378161720							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533323	Cc1nc(co1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H24F4N6O/c1-11-24-14(10-30-11)15-27-16(25-12-2-6-18(20,21)7-3-12)29-17(28-15)26-13-4-8-19(22,23)9-5-13/h10,12-13H,2-9H2,1H3,(H2,25,26,27,28,29)	KBXOUHBWHZCWAK-UHFFFAOYSA-N	280171	US10028961, Compound 324::US10172864, Compound 324::US10946023, Compound 324	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280171	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280171&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817327	378161721							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533324	CC(C)(O)CNc1nc(Nc2cc(F)cc(F)c2)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C18H16F5N7O/c1-17(2,31)8-25-15-28-14(13-24-4-3-12(27-13)18(21,22)23)29-16(30-15)26-11-6-9(19)5-10(20)7-11/h3-7,31H,8H2,1-2H3,(H2,25,26,28,29,30)	MDLNQVWWUAJKJT-UHFFFAOYSA-N	280172	US10028961, Compound 325::US10172864, Compound 325::US10946023, Compound 325	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280172	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280172&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799047	378161722							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533328	CN1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H22F5N7/c1-31-8-6-12(10-31)26-17-29-15(13-3-2-4-14(27-13)19(22,23)24)28-16(30-17)25-11-5-7-18(20,21)9-11/h2-4,11-12H,5-10H2,1H3,(H2,25,26,28,29,30)	FKUYTXAMGGWNHC-UHFFFAOYSA-N	279946	US10028961, Compound 326::US10028961, Compound 96::US10172864, Compound 96::US10946023, Compound 326	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279946	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279946&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817313	378161496							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533331	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(O)n1)C1CC1	InChI=1S/C18H24N6O/c1-10(12-6-7-12)19-17-22-16(14-4-3-5-15(25)21-14)23-18(24-17)20-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H,21,25)(H2,19,20,22,23,24)/t10-,11-/m1/s1	XCJURBVXBCWXNR-GHMZBOCLSA-N	280174	US10028961, Compound 327::US10172864, Compound 327::US10946023, Compound 327	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280174	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280174&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817341	378161723							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533332	Cc1nsc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C18H23F4N7S/c1-10-23-14(30-29-10)13-26-15(24-11-2-6-17(19,20)7-3-11)28-16(27-13)25-12-4-8-18(21,22)9-5-12/h11-12H,2-9H2,1H3,(H2,24,25,26,27,28)	YGASMFPIDZFMKN-UHFFFAOYSA-N	280175	US10028961, Compound 328::US10172864, Compound 328::US10946023, Compound 328	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280175	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280175&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817331	378161724							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533333	Cc1cc(no1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H24F4N6O/c1-11-10-14(29-30-11)15-26-16(24-12-2-6-18(20,21)7-3-12)28-17(27-15)25-13-4-8-19(22,23)9-5-13/h10,12-13H,2-9H2,1H3,(H2,24,25,26,27,28)	LHBMQURTVTWZJE-UHFFFAOYSA-N	280176	US10028961, Compound 329::US10172864, Compound 329::US10946023, Compound 329	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280176	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280176&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817558	378161725							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533334	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1ccn[nH]1	InChI=1S/C18H23F4N7/c19-17(20)6-1-11(2-7-17)24-15-26-14(13-5-10-23-29-13)27-16(28-15)25-12-3-8-18(21,22)9-4-12/h5,10-12H,1-4,6-9H2,(H,23,29)(H2,24,25,26,27,28)	JPXUIUIQYJBYGI-UHFFFAOYSA-N	280177	US10028961, Compound 330::US10172864, Compound 330::US10946023, Compound 330	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280177	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280177&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817574	378161726							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533335	CC(CN1CCCCC1)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C22H30F3N7/c1-14(13-32-11-4-3-5-12-32)26-20-29-19(17-7-6-8-18(28-17)22(23,24)25)30-21(31-20)27-15(2)16-9-10-16/h6-8,14-16H,3-5,9-13H2,1-2H3,(H2,26,27,29,30,31)/t14?,15-/m1/s1	PQCFYGRRHLHCMI-YSSOQSIOSA-N	280178	US10028961, Compound 331::US10172864, Compound 331::US10946023, Compound 331	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280178	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280178&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799488	378161727							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533336	Cc1nc(c[nH]1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H25F4N7/c1-11-24-10-14(25-11)15-28-16(26-12-2-6-18(20,21)7-3-12)30-17(29-15)27-13-4-8-19(22,23)9-5-13/h10,12-13H,2-9H2,1H3,(H,24,25)(H2,26,27,28,29,30)	OMGWTZOTCFNMGJ-UHFFFAOYSA-N	280179	US10028961, Compound 332::US10172864, Compound 332::US10946023, Compound 332	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280179	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280179&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817562	378161728							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533337	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1nc(ns1)-c1ccccc1	InChI=1S/C23H25F4N7S/c24-22(25)10-6-15(7-11-22)28-20-31-18(19-30-17(34-35-19)14-4-2-1-3-5-14)32-21(33-20)29-16-8-12-23(26,27)13-9-16/h1-5,15-16H,6-13H2,(H2,28,29,31,32,33)	VEBDQVKKCIRACB-UHFFFAOYSA-N	280180	US10028961, Compound 333::US10172864, Compound 333::US10946023, Compound 333	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280180	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280180&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817500	378161729							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533514	C[C@@H](Nc1cc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)/t11-,12-/m1/s1	MEKMADZCSPFPMP-VXGBXAGGSA-N	280255	US10028961, Compound 414::US10172864, Compound 414::US10946023, Compound 414	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280255	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280255&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817191	378161804							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533515	C[C@@H](Nc1cc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)/t11-,12-/m1/s1	MEKMADZCSPFPMP-VXGBXAGGSA-N	280255	US10028961, Compound 414::US10172864, Compound 414::US10946023, Compound 414	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280255	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280255&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817191	378161804							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533518	C[C@@H](Nc1cc(N[C@@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)/t11-,12+	MEKMADZCSPFPMP-TXEJJXNPSA-N	280256	US10028961, Compound 415::US10172864, Compound 415::US10946023, Compound 415	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280256	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280256&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817171	378161805							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533520	C[C@H](Nc1cc(N[C@@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)/t11-,12-/m0/s1	MEKMADZCSPFPMP-RYUDHWBXSA-N	280257	US10028961, Compound 416::US10172864, Compound 416::US10946023, Compound 416	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280257&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817194	378161806							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533521	C[C@H](Nc1cc(N[C@@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)/t11-,12-/m0/s1	MEKMADZCSPFPMP-RYUDHWBXSA-N	280257	US10028961, Compound 416::US10172864, Compound 416::US10946023, Compound 416	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280257&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817194	378161806							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533523	C[C@@H](Nc1cc(NC(C)(C)C)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C19H24F3N5/c1-11(12-8-9-12)23-15-10-16(27-18(2,3)4)26-17(25-15)13-6-5-7-14(24-13)19(20,21)22/h5-7,10-12H,8-9H2,1-4H3,(H2,23,25,26,27)/t11-/m1/s1	SICOBUZBFFTRIB-LLVKDONJSA-N	280258	US10028961, Compound 417::US10172864, Compound 417::US10946023, Compound 417	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280258	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280258&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817175	378161807							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533525	CC(Nc1cc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C18H19ClF5N5/c1-10(18(22,23)24)25-14-9-15(26-11-5-7-17(20,21)8-6-11)29-16(28-14)12-3-2-4-13(19)27-12/h2-4,9-11H,5-8H2,1H3,(H2,25,26,28,29)	KKGDMBANXIMCDA-UHFFFAOYSA-N	280259	US10028961, Compound 418	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280259	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280259&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123571386	378161808							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533526	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC2)cc(NCC2CC2)n1	InChI=1S/C18H20F3N5/c19-18(20,21)14-3-1-2-13(24-14)17-25-15(22-9-11-4-5-11)8-16(26-17)23-10-12-6-7-12/h1-3,8,11-12H,4-7,9-10H2,(H2,22,23,25,26)	QEJQVKBULWEUGT-UHFFFAOYSA-N	280260	US10028961, Compound 419::US10172864, Compound 419::US10946023, Compound 419	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280260	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280260&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817553	378161809							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533528	CC(Nc1cc(NC(C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)	MEKMADZCSPFPMP-UHFFFAOYSA-N	280261	US10028961, Compound 420::US10172864, Compound 420::US10946023, Compound 420	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795600	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280261	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280261&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817543	378161810							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533531	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)cc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H23F7N6/c22-19(23)5-1-12(2-6-19)30-16-9-17(31-13-3-7-20(24,25)8-4-13)34-18(33-16)14-10-29-11-15(32-14)21(26,27)28/h9-13H,1-8H2,(H2,30,31,33,34)	UGJNNXSKMGDBMZ-UHFFFAOYSA-N	280262	US10028961, Compound 421::US10172864, Compound 421::US10946023, Compound 421	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280262	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280262&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817529	378161811							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533532	C[C@@H](Nc1nc(NC(C(F)(F)F)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C14H10ClF9N6/c1-5(12(16,17)18)25-10-27-8(6-3-2-4-7(15)26-6)28-11(30-10)29-9(13(19,20)21)14(22,23)24/h2-5,9H,1H3,(H2,25,27,28,29,30)/t5-/m1/s1	VTJODCQTJUKOPV-RXMQYKEDSA-N	279947	US10028961, Compound 100::US10172864, Compound 100::US10946023, Compound 100	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279947	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279947&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817515	378161497							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533534	C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)/t6-,7-/m1/s1	QCZAWDGAVJMPTA-RNFRBKRXSA-N	279948	US10028961, Compound 101::US10172864, Compound 101::US10946023, Compound 101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279948	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279948&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	9UO	6VFZ,6VEI,6ADG,6ADI	117817422	378161498							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533535	C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)/t6-,7-/m1/s1	QCZAWDGAVJMPTA-RNFRBKRXSA-N	279948	US10028961, Compound 101::US10172864, Compound 101::US10946023, Compound 101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279948	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279948&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	9UO	6VFZ,6VEI,6ADG,6ADI	117817422	378161498							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533538	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(N[C@@H]2CCC(F)(F)C2)n1	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)/t10-,11+	JWMKUJAOIPXYIG-PHIMTYICSA-N	279949	US10028961, Compound 102::US10172864, Compound 102::US10946023, Compound 102	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279949	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279949&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799093	378161499							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533540	CCC(Nc1nc(NC(CC)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C16H17ClF6N6/c1-3-9(15(18,19)20)25-13-27-12(8-6-5-7-11(17)24-8)28-14(29-13)26-10(4-2)16(21,22)23/h5-7,9-10H,3-4H2,1-2H3,(H2,25,26,27,28,29)	SDUBFPITPDQUSW-UHFFFAOYSA-N	279950	US10028961, Compound 103::US10172864, Compound 103::US10946023, Compound 103	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279950	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279950&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817517	378161500							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533542	CC[C@@H](Nc1nc(N[C@H](CC)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C16H17ClF6N6/c1-3-9(15(18,19)20)25-13-27-12(8-6-5-7-11(17)24-8)28-14(29-13)26-10(4-2)16(21,22)23/h5-7,9-10H,3-4H2,1-2H3,(H2,25,26,27,28,29)/t9-,10-/m1/s1	SDUBFPITPDQUSW-NXEZZACHSA-N	279951	US10028961, Compound 104::US10172864, Compound 104::US10946023, Compound 104	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279951	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279951&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817514	378161501							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533543	CC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C20H22F6N6/c1-18(21,22)14-4-2-3-13(29-14)15-30-16(27-11-5-7-19(23,24)9-11)32-17(31-15)28-12-6-8-20(25,26)10-12/h2-4,11-12H,5-10H2,1H3,(H2,27,28,30,31,32)	RZUPVAWGQZNFEZ-UHFFFAOYSA-N	279952	US10028961, Compound 105::US10172864, Compound 105::US10946023, Compound 105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279952	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279952&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817521	378161502							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533545	Fc1cc(F)cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-n2ccc(n2)C(F)(F)F)c1	InChI=1S/C17H12F7N7/c18-8-3-9(19)5-10(4-8)25-13-27-14(26-11-6-16(20,21)7-11)29-15(28-13)31-2-1-12(30-31)17(22,23)24/h1-5,11H,6-7H2,(H2,25,26,27,28,29)	XSFFZJKIWXEYIL-UHFFFAOYSA-N	279953	US10028961, Compound 106::US10172864, Compound 106::US10946023, Compound 106	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279953	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279953&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799077	378161503							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533548	CC(Nc1nc(Nc2cc(F)cc(F)c2)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C16H11F8N7/c1-7(15(19,20)21)25-12-27-13(26-10-5-8(17)4-9(18)6-10)29-14(28-12)31-3-2-11(30-31)16(22,23)24/h2-7H,1H3,(H2,25,26,27,28,29)	AQCLVWSTMGVZRR-UHFFFAOYSA-N	279954	US10028961, Compound 107::US10172864, Compound 107::US10946023, Compound 107	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279954	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279954&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817516	378161504							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533550	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-n2ccc(n2)C(F)(F)F)c1	InChI=1S/C18H14F7N7/c19-9-5-10(20)7-12(6-9)27-15-28-14(26-11-1-3-17(21,22)8-11)29-16(30-15)32-4-2-13(31-32)18(23,24)25/h2,4-7,11H,1,3,8H2,(H2,26,27,28,29,30)	UFZDFINJOJHYMD-UHFFFAOYSA-N	279955	US10028961, Compound 108::US10172864, Compound 108::US10946023, Compound 108	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279955	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279955&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817518	378161505							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533553	CCC(Nc1nc(NC(CC)C2CC2)nc(n1)-c1cccc(Cl)n1)C1CC1	InChI=1S/C20H27ClN6/c1-3-14(12-8-9-12)23-19-25-18(16-6-5-7-17(21)22-16)26-20(27-19)24-15(4-2)13-10-11-13/h5-7,12-15H,3-4,8-11H2,1-2H3,(H2,23,24,25,26,27)	SDVGLHHVYYZRJZ-UHFFFAOYSA-N	279957	US10028961, Compound 110::US10172864, Compound 110::US10946023, Compound 110	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279957	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279957&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817125	378161507							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533556	FC(F)(F)c1cccc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(N[C@@H]2CCC(F)(F)C2)n1	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)/t10-,11-/m1/s1	JWMKUJAOIPXYIG-GHMZBOCLSA-N	279958	US10028961, Compound 111::US10172864, Compound 111::US10946023, Compound 111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279958	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279958&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817150	378161508							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533558	Fc1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-n2ccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C19H14F6N8/c20-11-5-10(9-26)6-13(7-11)28-16-29-15(27-12-1-3-18(21,22)8-12)30-17(31-16)33-4-2-14(32-33)19(23,24)25/h2,4-7,12H,1,3,8H2,(H2,27,28,29,30,31)	GOMGSGWMVHCJSA-UHFFFAOYSA-N	279959	US10028961, Compound 112::US10172864, Compound 112::US10946023, Compound 112	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279959	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279959&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817138	378161509							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533560	FC1(F)CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(Cl)n1	InChI=1S/C18H19ClF4N6/c19-13-3-1-2-12(26-13)14-27-15(24-10-4-6-17(20,21)8-10)29-16(28-14)25-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,24,25,27,28,29)	WFTCEDYVKXKHBE-UHFFFAOYSA-N	279960	US10028961, Compound 113::US10172864, Compound 113::US10946023, Compound 113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279960	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279960&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817141	378161510							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533564	FC(F)(F)c1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(Cl)n2)ccn1	InChI=1S/C19H15ClF5N7/c20-14-3-1-2-12(29-14)15-30-16(27-10-5-7-26-13(8-10)19(23,24)25)32-17(31-15)28-11-4-6-18(21,22)9-11/h1-3,5,7-8,11H,4,6,9H2,(H2,26,27,28,30,31,32)	GCDKECOSGNFZAP-UHFFFAOYSA-N	279962	US10028961, Compound 115::US10172864, Compound 115::US10946023, Compound 115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279962	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279962&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798735	378161512							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533566	FC(F)(F)c1cncc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C19H14F8N8/c20-17(21)3-1-10(6-17)31-16-34-14(11-7-28-8-13(32-11)19(25,26)27)33-15(35-16)30-9-2-4-29-12(5-9)18(22,23)24/h2,4-5,7-8,10H,1,3,6H2,(H2,29,30,31,33,34,35)/t10-/m1/s1	ONCVYPCVWHYEJW-SNVBAGLBSA-N	279963	US10028961, Compound 116::US10172864, Compound 116::US10946023, Compound 116	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279963	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279963&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799248	378161513							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533567	FC(F)(F)c1cncc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C19H14F8N8/c20-17(21)3-1-10(6-17)31-16-34-14(11-7-28-8-13(32-11)19(25,26)27)33-15(35-16)30-9-2-4-29-12(5-9)18(22,23)24/h2,4-5,7-8,10H,1,3,6H2,(H2,29,30,31,33,34,35)/t10-/m1/s1	ONCVYPCVWHYEJW-SNVBAGLBSA-N	279963	US10028961, Compound 116::US10172864, Compound 116::US10946023, Compound 116	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279963	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279963&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799248	378161513							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533570	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(N[C@H]2CCC(F)(F)C2)n1	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)/t10-,11-/m0/s1	JWMKUJAOIPXYIG-QWRGUYRKSA-N	279965	US10028961, Compound 118::US10172864, Compound 118::US10946023, Compound 118	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279965	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279965&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817143	378161515							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533572	CC(Nc1nc(Nc2cc(F)cc(c2)C#N)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C17H11F7N8/c1-8(16(19,20)21)26-13-28-14(27-11-5-9(7-25)4-10(18)6-11)30-15(29-13)32-3-2-12(31-32)17(22,23)24/h2-6,8H,1H3,(H2,26,27,28,29,30)	WXBOZLIIKJDCRJ-UHFFFAOYSA-N	279966	US10028961, Compound 119::US10172864, Compound 119::US10946023, Compound 119	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279966	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279966&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817540	378161516							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533574	Fc1cc(F)cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2cncc(Cl)n2)c1	InChI=1S/C17H12ClF4N7/c18-13-7-23-6-12(26-13)14-27-15(24-10-2-8(19)1-9(20)3-10)29-16(28-14)25-11-4-17(21,22)5-11/h1-3,6-7,11H,4-5H2,(H2,24,25,27,28,29)	DJUDMNYUQIPAHU-UHFFFAOYSA-N	279967	US10028961, Compound 120::US10172864, Compound 120::US10946023, Compound 120	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279967	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279967&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799523	378161517							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533576	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-n1ccc(n1)C(F)(F)F)C1CC1	InChI=1S/C17H22F3N7/c1-9(11-3-4-11)21-14-23-15(22-10(2)12-5-6-12)25-16(24-14)27-8-7-13(26-27)17(18,19)20/h7-12H,3-6H2,1-2H3,(H2,21,22,23,24,25)/t9-,10-/m1/s1	ZFCNVKABVPLJJM-NXEZZACHSA-N	279968	US10028961, Compound 121::US10172864, Compound 121::US10946023, Compound 121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279968	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279968&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817536	378161518							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533578	Fc1cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2nc(cs2)C(F)(F)F)cc(c1)C#N	InChI=1S/C18H11F6N7S/c19-9-1-8(6-25)2-10(3-9)26-15-29-13(14-28-12(7-32-14)18(22,23)24)30-16(31-15)27-11-4-17(20,21)5-11/h1-3,7,11H,4-5H2,(H2,26,27,29,30,31)	MHTOHBOHQAYWJP-UHFFFAOYSA-N	279969	US10028961, Compound 122::US10172864, Compound 122::US10946023, Compound 122	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279969	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279969&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799023	378161519							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533580	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)c1	InChI=1S/C20H15F7N6/c21-10-6-11(22)8-13(7-10)29-18-32-16(14-2-1-3-15(30-14)20(25,26)27)31-17(33-18)28-12-4-5-19(23,24)9-12/h1-3,6-8,12H,4-5,9H2,(H2,28,29,31,32,33)	DTFRDAWQNHNMEU-UHFFFAOYSA-N	279970	US10028961, Compound 123::US10172864, Compound 123::US10946023, Compound 123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279970	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279970&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798777	378161520							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533582	Fc1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C21H15F6N7/c22-12-6-11(10-28)7-14(8-12)30-19-33-17(15-2-1-3-16(31-15)21(25,26)27)32-18(34-19)29-13-4-5-20(23,24)9-13/h1-3,6-8,13H,4-5,9H2,(H2,29,30,32,33,34)	NTKHRYLRDAXKRH-UHFFFAOYSA-N	279971	US10028961, Compound 124::US10172864, Compound 124::US10946023, Compound 124	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279971	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279971&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799282	378161521							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533585	FC(F)(F)c1ccn(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H14F7N7/c16-13(17)3-7(4-13)23-10-25-11(24-8-5-14(18,19)6-8)27-12(26-10)29-2-1-9(28-29)15(20,21)22/h1-2,7-8H,3-6H2,(H2,23,24,25,26,27)	NYHCCPXGTKQDAW-UHFFFAOYSA-N	279973	US10028961, Compound 126::US10172864, Compound 126::US10946023, Compound 126	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279973	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279973&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817544	378161523							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533587	FC1(F)CCC(C1)Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(Cl)n1	InChI=1S/C22H19ClF2N8/c23-17-3-1-2-15(30-17)18-31-19(33-20(32-18)29-14-4-6-22(24,25)11-14)28-13-5-9-27-16(10-13)21(12-26)7-8-21/h1-3,5,9-10,14H,4,6-8,11H2,(H2,27,28,29,31,32,33)	ZENVCUIOSQAXHI-UHFFFAOYSA-N	279974	US10028961, Compound 127::US10172864, Compound 127::US10946023, Compound 127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279974	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279974&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799128	378161524							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533590	FC(F)(F)c1csc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H13F7N6S/c16-13(17)1-6(2-13)23-11-26-9(10-25-8(5-29-10)15(20,21)22)27-12(28-11)24-7-3-14(18,19)4-7/h5-7H,1-4H2,(H2,23,24,26,27,28)	DSJXHLDOLTTWGN-UHFFFAOYSA-N	279975	US10028961, Compound 128::US10172864, Compound 128::US10946023, Compound 128	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279975	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279975&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817465	378161525							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533593	CC(Nc1nc(NC(C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)	QCZAWDGAVJMPTA-UHFFFAOYSA-N	279977	US10028961, Compound 130::US10172864, Compound 130::US10946023, Compound 130	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279977	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279977&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	9UO	6VFZ,6VEI,6ADG,6ADI	117817435	378161527							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533594	Clc1cccc(n1)-c1nc(NC(C2CC2)C2CC2)nc(NC(C2CC2)C2CC2)n1	InChI=1S/C22H27ClN6/c23-17-3-1-2-16(24-17)20-27-21(25-18(12-4-5-12)13-6-7-13)29-22(28-20)26-19(14-8-9-14)15-10-11-15/h1-3,12-15,18-19H,4-11H2,(H2,25,26,27,28,29)	UYZPRJVBJGBQLI-UHFFFAOYSA-N	279978	US10028961, Compound 131::US10172864, Compound 131::US10946023, Compound 131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279978	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279978&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817455	378161528							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533596	Fc1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2nc(cs2)C(F)(F)F)cc(c1)[N+]#[C-]	InChI=1S/C19H13F6N7S/c1-26-11-4-9(20)5-12(6-11)28-17-31-14(15-29-13(8-33-15)19(23,24)25)30-16(32-17)27-10-2-3-18(21,22)7-10/h4-6,8,10H,2-3,7H2,(H2,27,28,30,31,32)	KEBOTYHGXMTVHD-UHFFFAOYSA-N	279979	US10028961, Compound 132::US10172864, Compound 132	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279979	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279979&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123723292	378161529							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533598	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C23H19F5N8/c24-22(25)6-4-14(11-22)32-20-35-18(15-2-1-3-16(33-15)23(26,27)28)34-19(36-20)31-13-5-9-30-17(10-13)21(12-29)7-8-21/h1-3,5,9-10,14H,4,6-8,11H2,(H2,30,31,32,34,35,36)/t14-/m0/s1	FQOVWGJWJAOWBO-AWEZNQCLSA-N	279980	US10028961, Compound 133::US10172864, Compound 133::US10946023, Compound 133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279980	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279980&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817510	378161530							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533601	CC(Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C20H16ClF3N8/c1-11(20(22,23)24)27-17-30-16(13-3-2-4-15(21)29-13)31-18(32-17)28-12-5-8-26-14(9-12)19(10-25)6-7-19/h2-5,8-9,11H,6-7H2,1H3,(H2,26,27,28,30,31,32)	CFSIYYWIWLPLNQ-UHFFFAOYSA-N	279981	US10028961, Compound 134::US10172864, Compound 134::US10946023, Compound 134	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279981	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279981&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817443	378161531							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533604	C[C@@H](Nc1nc(N[C@@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)/t6-,7+	QCZAWDGAVJMPTA-KNVOCYPGSA-N	279983	US10028961, Compound 136::US10172864, Compound 136::US10946023, Compound 136	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279983	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279983&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817448	378161533							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533606	FC(F)(F)c1cccc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C23H19F5N8/c24-22(25)6-4-14(11-22)32-20-35-18(15-2-1-3-16(33-15)23(26,27)28)34-19(36-20)31-13-5-9-30-17(10-13)21(12-29)7-8-21/h1-3,5,9-10,14H,4,6-8,11H2,(H2,30,31,32,34,35,36)/t14-/m1/s1	FQOVWGJWJAOWBO-CQSZACIVSA-N	279984	US10028961, Compound 137::US10172864, Compound 137::US10946023, Compound 137	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279984	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279984&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799135	378161534							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533609	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H18F7N7/c19-16(20)3-1-9(5-16)27-14-30-13(11-7-26-8-12(29-11)18(23,24)25)31-15(32-14)28-10-2-4-17(21,22)6-10/h7-10H,1-6H2,(H2,27,28,30,31,32)	YWUBJNPVIIBDPD-UHFFFAOYSA-N	279985	US10028961, Compound 138::US10172864, Compound 138::US10946023, Compound 138	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279985	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279985&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817513	378161535							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533612	Fc1cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-n2ccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C18H12F6N8/c19-10-3-9(8-25)4-11(5-10)26-14-28-15(27-12-6-17(20,21)7-12)30-16(29-14)32-2-1-13(31-32)18(22,23)24/h1-5,12H,6-7H2,(H2,26,27,28,29,30)	LDOFFBDPIFZNNG-UHFFFAOYSA-N	279987	US10028961, Compound 140::US10172864, Compound 140::US10946023, Compound 140	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279987	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279987&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799247	378161537							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533614	CC(Nc1nc(NC(C)C(F)(F)F)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C13H12F9N7/c1-5(11(14,15)16)23-8-25-9(24-6(2)12(17,18)19)27-10(26-8)29-4-3-7(28-29)13(20,21)22/h3-6H,1-2H3,(H2,23,24,25,26,27)	FYQXPMJBVPBLMP-UHFFFAOYSA-N	279988	US10028961, Compound 141::US10172864, Compound 141::US10946023, Compound 141	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279988	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279988&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817582	378161538							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533616	C[C@H](Nc1nc(N[C@@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)/t6-,7-/m0/s1	QCZAWDGAVJMPTA-BQBZGAKWSA-N	279989	US10028961, Compound 142::US10172864, Compound 142::US10946023, Compound 142	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279989	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279989&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817339	378161539							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533618	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(5-7-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-8-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	ACLXKIHIMONNBV-UHFFFAOYSA-N	279990	US10028961, Compound 143::US10172864, Compound 143::US10946023, Compound 143	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279990	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279990&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817512	378161540							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533620	FC1(F)CC(C1)Nc1nc(NC2CC(F)(F)C2)nc(n1)-c1cncc(Cl)n1	InChI=1S/C15H14ClF4N7/c16-10-6-21-5-9(24-10)11-25-12(22-7-1-14(17,18)2-7)27-13(26-11)23-8-3-15(19,20)4-8/h5-8H,1-4H2,(H2,22,23,25,26,27)	YLBDZIMKQYQWBZ-UHFFFAOYSA-N	279991	US10028961, Compound 144::US10172864, Compound 144::US10946023, Compound 144	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279991	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279991&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817496	378161541							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533622	FC(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C17H16F6N6/c18-12(19)10-2-1-3-11(26-10)13-27-14(24-8-4-16(20,21)5-8)29-15(28-13)25-9-6-17(22,23)7-9/h1-3,8-9,12H,4-7H2,(H2,24,25,27,28,29)	CMDVCIGBLUTSCG-UHFFFAOYSA-N	279992	US10028961, Compound 145::US10172864, Compound 145::US10946023, Compound 145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279992	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279992&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466129	378161542							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533624	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C17H18F7N7/c18-15(19)4-1-9(7-15)25-12-27-13(26-10-2-5-16(20,21)8-10)29-14(28-12)31-6-3-11(30-31)17(22,23)24/h3,6,9-10H,1-2,4-5,7-8H2,(H2,25,26,27,28,29)	MLJRZPLHOBYNMG-UHFFFAOYSA-N	279993	US10028961, Compound 146::US10172864, Compound 146::US10946023, Compound 146	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279993	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279993&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817473	378161543							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533626	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cncc(Cl)n1	InChI=1S/C19H22ClF4N7/c20-14-10-25-9-13(28-14)15-29-16(26-11-1-5-18(21,22)6-2-11)31-17(30-15)27-12-3-7-19(23,24)8-4-12/h9-12H,1-8H2,(H2,26,27,29,30,31)	MEWHAARPVJKYDP-UHFFFAOYSA-N	279994	US10028961, Compound 147::US10172864, Compound 147::US10946023, Compound 147	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279994	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279994&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817495	378161544							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533629	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C17H15F7N6/c18-15(19)4-8(5-15)25-13-28-12(10-2-1-3-11(27-10)17(22,23)24)29-14(30-13)26-9-6-16(20,21)7-9/h1-3,8-9H,4-7H2,(H2,25,26,28,29,30)	GJNPRCBREKXFRM-UHFFFAOYSA-N	279996	US10028961, Compound 149::US10172864, Compound 149::US10946023, Compound 149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279996	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279996&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817132	378161546							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533632	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C23H19F5N8/c1-29-21(8-9-21)17-11-13(6-10-30-17)31-19-34-18(15-3-2-4-16(33-15)23(26,27)28)35-20(36-19)32-14-5-7-22(24,25)12-14/h2-4,6,10-11,14H,5,7-9,12H2,(H2,30,31,32,34,35,36)	LVLCYRFGYKSVJF-UHFFFAOYSA-N	279998	US10028961, Compound 151::US10172864, Compound 151	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279998	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279998&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123318205	378161548							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533634	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccccc3C2)n1	InChI=1S/C23H21F5N6/c24-22(25)9-8-15(12-22)29-20-32-19(17-6-3-7-18(31-17)23(26,27)28)33-21(34-20)30-16-10-13-4-1-2-5-14(13)11-16/h1-7,15-16H,8-12H2,(H2,29,30,32,33,34)	WFJGUJXRROVRQM-UHFFFAOYSA-N	279999	US10028961, Compound 152::US10172864, Compound 152::US10946023, Compound 152	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279999	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279999&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817119	378161549							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533636	Nc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2cc(F)cc(F)c2)n1	InChI=1S/C19H16F5N7/c20-9-5-10(21)7-12(6-9)27-18-30-16(15-13(22)1-2-14(25)28-15)29-17(31-18)26-11-3-4-19(23,24)8-11/h1-2,5-7,11H,3-4,8H2,(H2,25,28)(H2,26,27,29,30,31)	QJZUODUNLOWRRS-UHFFFAOYSA-N	280000	US10028961, Compound 153::US10172864, Compound 153::US10946023, Compound 153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280000	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280000&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799273	378161550							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533637	Fc1cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C20H13F6N7/c21-11-4-10(9-27)5-12(6-11)28-17-31-16(14-2-1-3-15(30-14)20(24,25)26)32-18(33-17)29-13-7-19(22,23)8-13/h1-6,13H,7-8H2,(H2,28,29,31,32,33)	NLDPPNGLSHUYFG-UHFFFAOYSA-N	280001	US10028961, Compound 154::US10172864, Compound 154::US10946023, Compound 154	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280001	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280001&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817126	378161551							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533639	CC(F)(F)c1nc(cs1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H20F6N6S/c1-16(19,20)13-27-11(8-31-13)12-28-14(25-9-2-4-17(21,22)6-9)30-15(29-12)26-10-3-5-18(23,24)7-10/h8-10H,2-7H2,1H3,(H2,25,26,28,29,30)	OMZLJEXLAIMEOS-UHFFFAOYSA-N	280002	US10028961, Compound 155::US10172864, Compound 155::US10946023, Compound 155	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280002	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280002&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817127	378161552							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533641	CC(Nc1nc(NC(C)C(F)(F)F)nc(n1)-c1cncc(Cl)n1)C(F)(F)F	InChI=1S/C13H12ClF6N7/c1-5(12(15,16)17)22-10-25-9(7-3-21-4-8(14)24-7)26-11(27-10)23-6(2)13(18,19)20/h3-6H,1-2H3,(H2,22,23,25,26,27)	QETWKMKQNIKDLH-UHFFFAOYSA-N	280003	US10028961, Compound 156::US10172864, Compound 156::US10946023, Compound 156	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280003	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280003&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817111	378161553							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533643	FC1(F)CCCC1Nc1nc(NC2CCCC2(F)F)nc(n1)-c1cccc(Cl)n1	InChI=1S/C18H19ClF4N6/c19-13-7-1-4-10(24-13)14-27-15(25-11-5-2-8-17(11,20)21)29-16(28-14)26-12-6-3-9-18(12,22)23/h1,4,7,11-12H,2-3,5-6,8-9H2,(H2,25,26,27,28,29)	PDSKCDIBFYQGCE-UHFFFAOYSA-N	280004	US10028961, Compound 157::US10172864, Compound 157::US10946023, Compound 157	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280004	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280004&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817134	378161554							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533645	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H15F8N7/c21-18(22)6-4-11(9-18)31-17-34-15(12-2-1-3-13(32-12)19(23,24)25)33-16(35-17)30-10-5-7-29-14(8-10)20(26,27)28/h1-3,5,7-8,11H,4,6,9H2,(H2,29,30,31,33,34,35)/t11-/m0/s1	PDXMOPYZKDLAPA-NSHDSACASA-N	280005	US10028961, Compound 158::US10172864, Compound 158::US10946023, Compound 158	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280005	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280005&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799020	378161555							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533648	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2nc(cs2)C(F)(F)F)c1	InChI=1S/C18H13F7N6S/c19-8-3-9(20)5-11(4-8)27-16-30-13(14-28-12(7-32-14)18(23,24)25)29-15(31-16)26-10-1-2-17(21,22)6-10/h3-5,7,10H,1-2,6H2,(H2,26,27,29,30,31)	YXCYCZLJJZKMJO-UHFFFAOYSA-N	280006	US10028961, Compound 159::US10172864, Compound 159::US10946023, Compound 159	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280006	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280006&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817493	378161556							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533650	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F7N7/c21-18(22)5-1-11(2-6-18)29-16-32-15(13-9-28-10-14(31-13)20(25,26)27)33-17(34-16)30-12-3-7-19(23,24)8-4-12/h9-12H,1-8H2,(H2,29,30,32,33,34)	SUGBJFIPDULVRS-UHFFFAOYSA-N	280007	US10028961, Compound 160::US10172864, Compound 160::US10946023, Compound 160	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280007	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280007&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817538	378161557							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533653	FC(F)(F)c1cncc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H14F7N7/c17-14(18)1-7(2-14)25-12-28-11(9-5-24-6-10(27-9)16(21,22)23)29-13(30-12)26-8-3-15(19,20)4-8/h5-8H,1-4H2,(H2,25,26,28,29,30)	BJUUMSAHTGGBTK-UHFFFAOYSA-N	280008	US10028961, Compound 161::US10172864, Compound 161::US10946023, Compound 161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280008	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280008&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817567	378161558							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533656	CC(C)(C)Nc1nc(Nc2ccnc(c2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H17F3N8/c1-18(2,3)30-17-28-15(13-5-4-6-14(26-13)19(20,21)22)27-16(29-17)25-11-7-8-24-12(9-11)10-23/h4-9H,1-3H3,(H2,24,25,27,28,29,30)	AJDWHCKBPZAYQS-UHFFFAOYSA-N	280009	US10028961, Compound 162::US10172864, Compound 162::US10946023, Compound 162	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280009	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280009&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799392	378161559							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533658	CC(F)(F)c1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)ccn1	InChI=1S/C21H18F7N7/c1-19(22,23)15-9-11(6-8-29-15)30-17-33-16(13-3-2-4-14(32-13)21(26,27)28)34-18(35-17)31-12-5-7-20(24,25)10-12/h2-4,6,8-9,12H,5,7,10H2,1H3,(H2,29,30,31,33,34,35)	RJZGABPOSOZJRY-UHFFFAOYSA-N	280010	US10028961, Compound 163::US10172864, Compound 163::US10946023, Compound 163	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280010	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280010&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817586	378161560							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533660	Fc1cc(Nc2nc(NC3CCC(F)(F)CC3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C22H17F6N7/c23-13-8-12(11-29)9-15(10-13)31-20-34-18(16-2-1-3-17(32-16)22(26,27)28)33-19(35-20)30-14-4-6-21(24,25)7-5-14/h1-3,8-10,14H,4-7H2,(H2,30,31,33,34,35)	RAQUPWWEGSOPEV-UHFFFAOYSA-N	280011	US10028961, Compound 164::US10172864, Compound 164::US10946023, Compound 164	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280011	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280011&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817554	378161561							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533662	Nc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2cc(F)cc(F)c2)n1	InChI=1S/C20H18F5N7/c21-10-7-11(22)9-13(8-10)28-19-31-17(16-14(23)1-2-15(26)29-16)30-18(32-19)27-12-3-5-20(24,25)6-4-12/h1-2,7-9,12H,3-6H2,(H2,26,29)(H2,27,28,30,31,32)	JAYZPFRYKWCBQZ-UHFFFAOYSA-N	280012	US10028961, Compound 165::US10172864, Compound 165::US10946023, Compound 165	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280012	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280012&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799099	378161562							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533665	C[C@@H](Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(Cl)n1)C1CC1	InChI=1S/C22H21ClN8/c1-13(14-5-6-14)26-20-29-19(16-3-2-4-18(23)28-16)30-21(31-20)27-15-7-10-25-17(11-15)22(12-24)8-9-22/h2-4,7,10-11,13-14H,5-6,8-9H2,1H3,(H2,25,26,27,29,30,31)/t13-/m1/s1	YPMMASFCPXGGFB-CYBMUJFWSA-N	280014	US10028961, Compound 167::US10172864, Compound 167::US10946023, Compound 167	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280014	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280014&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799158	378161564							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533668	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C22H17F5N8/c1-28-20(6-7-20)16-9-12(5-8-29-16)30-18-33-17(14-3-2-4-15(32-14)22(25,26)27)34-19(35-18)31-13-10-21(23,24)11-13/h2-5,8-9,13H,6-7,10-11H2,(H2,29,30,31,33,34,35)	MNROPBMECNHKDS-UHFFFAOYSA-N	280015	US10028961, Compound 168::US10172864, Compound 168	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280015	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280015&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123886256	378161565							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533671	FC(F)(F)c1ccn(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C20H16F5N9/c1-26-18(4-5-18)14-8-11(2-6-27-14)28-15-30-16(29-12-9-19(21,22)10-12)32-17(31-15)34-7-3-13(33-34)20(23,24)25/h2-3,6-8,12H,4-5,9-10H2,(H2,27,28,29,30,31,32)	BYFJDMHRGJRSCN-UHFFFAOYSA-N	280016	US10028961, Compound 169::US10172864, Compound 169	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280016	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280016&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124026281	378161566							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533673	FC(F)(F)c1nc(cs1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H13F7N6S/c16-13(17)1-6(2-13)23-11-26-9(8-5-29-10(25-8)15(20,21)22)27-12(28-11)24-7-3-14(18,19)4-7/h5-7H,1-4H2,(H2,23,24,26,27,28)	PFVOIDGYPOBGID-UHFFFAOYSA-N	280017	US10028961, Compound 170::US10172864, Compound 170::US10946023, Compound 170	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280017	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280017&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817334	378161567							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533675	CC(Nc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C18H12F9N7/c1-8(16(19,20)21)29-14-32-13(10-3-2-4-11(31-10)17(22,23)24)33-15(34-14)30-9-5-6-28-12(7-9)18(25,26)27/h2-8H,1H3,(H2,28,29,30,32,33,34)	RJRSWUFHCKWNQG-UHFFFAOYSA-N	280018	US10028961, Compound 171::US10172864, Compound 171::US10946023, Compound 171	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280018	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280018&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799090	378161568							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533677	FC(F)(F)c1cccc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H15F8N7/c21-18(22)6-4-11(9-18)31-17-34-15(12-2-1-3-13(32-12)19(23,24)25)33-16(35-17)30-10-5-7-29-14(8-10)20(26,27)28/h1-3,5,7-8,11H,4,6,9H2,(H2,29,30,31,33,34,35)/t11-/m1/s1	PDXMOPYZKDLAPA-LLVKDONJSA-N	280019	US10028961, Compound 172::US10172864, Compound 172::US10946023, Compound 172	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280019	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280019&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798963	378161569							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533679	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C18H14F8N8/c19-16(20)4-1-10(8-16)29-14-30-13(28-9-2-5-27-12(7-9)18(24,25)26)31-15(32-14)34-6-3-11(33-34)17(21,22)23/h2-3,5-7,10H,1,4,8H2,(H2,27,28,29,30,31,32)	RACFSMUYWZWUMF-UHFFFAOYSA-N	280020	US10028961, Compound 173::US10172864, Compound 173::US10946023, Compound 173	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280020	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280020&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798964	378161570							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533681	FC(F)(F)c1ccn(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C21H18F5N9/c1-27-19(6-7-19)15-10-12(3-8-28-15)29-16-31-17(30-13-2-5-20(22,23)11-13)33-18(32-16)35-9-4-14(34-35)21(24,25)26/h3-4,8-10,13H,2,5-7,11H2,(H2,28,29,30,31,32,33)/t13-/m0/s1	ZSYUHTUAGISLHX-ZDUSSCGKSA-N	280021	US10028961, Compound 174::US10172864, Compound 174	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280021	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280021&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123271414	378161571							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533684	Fc1cc(Nc2nc(NCC3CC3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)[N+]#[C-]	InChI=1S/C20H15F4N7/c1-25-13-7-12(21)8-14(9-13)27-19-30-17(29-18(31-19)26-10-11-5-6-11)15-3-2-4-16(28-15)20(22,23)24/h2-4,7-9,11H,5-6,10H2,(H2,26,27,29,30,31)	JVFNMBJVSBMSCG-UHFFFAOYSA-N	280022	US10028961, Compound 175::US10172864, Compound 175	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280022	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280022&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123300524	378161572							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533686	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H22F7N7/c20-17(21)6-1-11(2-7-17)27-14-29-15(28-12-3-8-18(22,23)9-4-12)31-16(30-14)33-10-5-13(32-33)19(24,25)26/h5,10-12H,1-4,6-9H2,(H2,27,28,29,30,31)	SLPLEYMIEBFOSW-UHFFFAOYSA-N	280023	US10028961, Compound 176::US10172864, Compound 176::US10946023, Compound 176	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280023	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280023&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817355	378161573							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533688	CC(Nc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C16H11F9N8/c1-7(14(17,18)19)27-11-29-12(28-8-2-4-26-10(6-8)16(23,24)25)31-13(30-11)33-5-3-9(32-33)15(20,21)22/h2-7H,1H3,(H2,26,27,28,29,30,31)	ORPDRKJAHZEOLR-UHFFFAOYSA-N	280024	US10028961, Compound 177::US10172864, Compound 177::US10946023, Compound 177	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280024	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280024&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817357	378161574							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533690	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H15F8N7/c21-18(22)6-4-11(9-18)31-17-34-15(12-2-1-3-13(32-12)19(23,24)25)33-16(35-17)30-10-5-7-29-14(8-10)20(26,27)28/h1-3,5,7-8,11H,4,6,9H2,(H2,29,30,31,33,34,35)	PDXMOPYZKDLAPA-UHFFFAOYSA-N	280025	US10028961, Compound 178::US10172864, Compound 178::US10946023, Compound 178	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280025	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280025&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798985	378161575							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533693	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C18H14F5N9/c19-17(20)4-1-11(8-17)27-15-28-14(26-10-2-5-25-12(7-10)9-24)29-16(30-15)32-6-3-13(31-32)18(21,22)23/h2-3,5-7,11H,1,4,8H2,(H2,25,26,27,28,29,30)	LUJOXCPZQNCMMB-UHFFFAOYSA-N	280026	US10028961, Compound 179::US10172864, Compound 179::US10946023, Compound 179	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280026	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280026&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817116	378161576							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533695	CC[C@H](Nc1nc(N[C@@H](CC)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C16H17ClF6N6/c1-3-9(15(18,19)20)25-13-27-12(8-6-5-7-11(17)24-8)28-14(29-13)26-10(4-2)16(21,22)23/h5-7,9-10H,3-4H2,1-2H3,(H2,25,26,27,28,29)/t9-,10-/m0/s1	SDUBFPITPDQUSW-UWVGGRQHSA-N	280027	US10028961, Compound 180::US10172864, Compound 180::US10946023, Compound 180	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280027	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280027&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817137	378161577							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533697	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C20H15F5N8/c21-19(22)6-4-12(9-19)29-18-32-16(14-2-1-3-15(30-14)20(23,24)25)31-17(33-18)28-11-5-7-27-13(8-11)10-26/h1-3,5,7-8,12H,4,6,9H2,(H2,27,28,29,31,32,33)	CPONOLJSMXHPCO-UHFFFAOYSA-N	280028	US10028961, Compound 181::US10172864, Compound 181::US10946023, Compound 181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280028	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280028&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799213	378161578							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533699	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccc(Cl)cc3C2)n1	InChI=1S/C23H20ClF5N6/c24-14-5-4-12-9-16(10-13(12)8-14)31-21-34-19(17-2-1-3-18(32-17)23(27,28)29)33-20(35-21)30-15-6-7-22(25,26)11-15/h1-5,8,15-16H,6-7,9-11H2,(H2,30,31,33,34,35)	XWCYRXFAEIUJMO-UHFFFAOYSA-N	280029	US10028961, Compound 182::US10172864, Compound 182::US10946023, Compound 182	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280029	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280029&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817114	378161579							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533701	FC(F)(F)c1csc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H21F7N6S/c20-17(21)5-1-10(2-6-17)27-15-30-13(14-29-12(9-33-14)19(24,25)26)31-16(32-15)28-11-3-7-18(22,23)8-4-11/h9-11H,1-8H2,(H2,27,28,30,31,32)	AKRQSKYNRTUAQA-UHFFFAOYSA-N	280030	US10028961, Compound 183::US10172864, Compound 183::US10946023, Compound 183	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280030	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280030&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817122	378161580							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533704	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C21H18F5N9/c22-20(23)4-1-13(10-20)30-17-31-16(29-12-2-7-28-15(9-12)19(11-27)5-6-19)32-18(33-17)35-8-3-14(34-35)21(24,25)26/h2-3,7-9,13H,1,4-6,10H2,(H2,28,29,30,31,32,33)	WFGLMCWPQJGAJJ-UHFFFAOYSA-N	280032	US10028961, Compound 185::US10172864, Compound 185::US10946023, Compound 185	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280032	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280032&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799291	378161582							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533706	FC(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H23F6N7/c21-15(22)13-9-27-10-14(30-13)16-31-17(28-11-1-5-19(23,24)6-2-11)33-18(32-16)29-12-3-7-20(25,26)8-4-12/h9-12,15H,1-8H2,(H2,28,29,31,32,33)	NNVCNVORYXXOAM-UHFFFAOYSA-N	280033	US10028961, Compound 186::US10172864, Compound 186::US10946023, Compound 186	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280033	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280033&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817121	378161583							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533708	CC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C18H18F6N6/c1-16(19,20)12-4-2-3-11(27-12)13-28-14(25-9-5-17(21,22)6-9)30-15(29-13)26-10-7-18(23,24)8-10/h2-4,9-10H,5-8H2,1H3,(H2,25,26,28,29,30)	YRSZQQILDIHZRT-UHFFFAOYSA-N	280034	US10028961, Compound 187::US10172864, Compound 187::US10946023, Compound 187	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280034	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280034&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817115	378161584							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533711	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C24H21F5N8/c1-30-22(10-11-22)18-13-15(7-12-31-18)33-21-36-19(16-3-2-4-17(34-16)24(27,28)29)35-20(37-21)32-14-5-8-23(25,26)9-6-14/h2-4,7,12-14H,5-6,8-11H2,(H2,31,32,33,35,36,37)	RLVMMYRYFBQTDM-UHFFFAOYSA-N	280036	US10028961, Compound 189::US10172864, Compound 189	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280036	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280036&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123396437	378161586							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533714	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C19H13F8N7/c20-17(21)7-10(8-17)30-16-33-14(11-2-1-3-12(31-11)18(22,23)24)32-15(34-16)29-9-4-5-28-13(6-9)19(25,26)27/h1-6,10H,7-8H2,(H2,28,29,30,32,33,34)	VURZKJCJGOOOFL-UHFFFAOYSA-N	280037	US10028961, Compound 190::US10172864, Compound 190::US10946023, Compound 190	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280037	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280037&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817505	378161587							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533717	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C21H21F7N6/c22-19(23)5-4-11(8-19)29-16-32-15(13-2-1-3-14(31-13)21(26,27)28)33-17(34-16)30-12-6-18(7-12)9-20(24,25)10-18/h1-3,11-12H,4-10H2,(H2,29,30,32,33,34)	RHCDZLRZYCRNDX-UHFFFAOYSA-N	280038	US10028961, Compound 191::US10172864, Compound 191::US10946023, Compound 191	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280038	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280038&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817431	378161588							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533719	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C21H17F8N7/c22-19(23)7-4-11(5-8-19)31-17-34-16(13-2-1-3-14(33-13)20(24,25)26)35-18(36-17)32-12-6-9-30-15(10-12)21(27,28)29/h1-3,6,9-11H,4-5,7-8H2,(H2,30,31,32,34,35,36)	ODBLPFGHFKRKHG-UHFFFAOYSA-N	280039	US10028961, Compound 192::US10172864, Compound 192::US10946023, Compound 192	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280039	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280039&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798913	378161589							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533721	C[C@@H](Nc1nc(NC(C2CC2)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C21H25F3N6/c1-11(12-5-6-12)25-19-28-18(15-3-2-4-16(26-15)21(22,23)24)29-20(30-19)27-17(13-7-8-13)14-9-10-14/h2-4,11-14,17H,5-10H2,1H3,(H2,25,27,28,29,30)/t11-/m1/s1	IEWNKIUGPADRRO-LLVKDONJSA-N	280040	US10028961, Compound 193::US10172864, Compound 193::US10946023, Compound 193	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280040	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280040&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817507	378161590							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533724	FC(F)(F)c1nccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H18F7N7/c19-16(20)4-1-9(7-16)27-14-30-12(11-3-6-26-13(29-11)18(23,24)25)31-15(32-14)28-10-2-5-17(21,22)8-10/h3,6,9-10H,1-2,4-5,7-8H2,(H2,27,28,30,31,32)	VWUHSVAZJFWQPW-UHFFFAOYSA-N	280041	US10028961, Compound 194::US10172864, Compound 194::US10946023, Compound 194	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280041	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280041&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817504	378161591							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533726	Fc1cc(F)cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2nc(F)ccc2F)c1	InChI=1S/C18H12F6N6/c19-8-3-9(20)5-10(4-8)25-16-28-15(14-12(21)1-2-13(22)27-14)29-17(30-16)26-11-6-18(23,24)7-11/h1-5,11H,6-7H2,(H2,25,26,28,29,30)	YOKUNNSAZUOEON-UHFFFAOYSA-N	280042	US10028961, Compound 195::US10172864, Compound 195::US10946023, Compound 195	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280042	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280042&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798724	378161592							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533728	CC[C@@H](Nc1nc(N[C@@H](CC)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C16H17ClF6N6/c1-3-9(15(18,19)20)25-13-27-12(8-6-5-7-11(17)24-8)28-14(29-13)26-10(4-2)16(21,22)23/h5-7,9-10H,3-4H2,1-2H3,(H2,25,26,27,28,29)/t9-,10+	SDUBFPITPDQUSW-AOOOYVTPSA-N	280043	US10028961, Compound 196::US10172864, Compound 196::US10946023, Compound 196	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280043	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280043&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817506	378161593							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533730	FC(F)(F)c1ccn(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C17H12F8N8/c18-15(19)6-9(7-15)28-13-29-12(27-8-1-3-26-11(5-8)17(23,24)25)30-14(31-13)33-4-2-10(32-33)16(20,21)22/h1-5,9H,6-7H2,(H2,26,27,28,29,30,31)	GIXRLAOMSYYYTD-UHFFFAOYSA-N	280044	US10028961, Compound 197::US10172864, Compound 197::US10946023, Compound 197	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280044	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280044&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798951	378161594							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533733	Fc1ccc(cc1)[C@@H]1C[C@@H](C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C24H22F6N6/c25-15-6-4-13(5-7-15)14-10-17(11-14)32-22-35-20(18-2-1-3-19(33-18)24(28,29)30)34-21(36-22)31-16-8-9-23(26,27)12-16/h1-7,14,16-17H,8-12H2,(H2,31,32,34,35,36)/t14-,16?,17+	MVZVTAYGMMCXIJ-FHQBBSRKSA-N	280046	US10028961, Compound 199::US10172864, Compound 199::US10946023, Compound 199	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280046	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280046&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817184	378161596							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533735	FC(F)(F)c1cc(Nc2nc(NCC3CC3)nc(n2)-c2cccc(Cl)n2)ccn1	InChI=1S/C18H15ClF3N7/c19-14-3-1-2-12(26-14)15-27-16(24-9-10-4-5-10)29-17(28-15)25-11-6-7-23-13(8-11)18(20,21)22/h1-3,6-8,10H,4-5,9H2,(H2,23,24,25,27,28,29)	ZMPPKTRRHWZFFR-UHFFFAOYSA-N	280047	US10028961, Compound 200::US10172864, Compound 200::US10946023, Compound 200	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280047	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280047&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798795	378161597							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533737	CC(Nc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C19H15F6N9/c1-10(18(20,21)22)28-14-30-15(29-11-3-7-27-13(9-11)17(26-2)5-6-17)32-16(31-14)34-8-4-12(33-34)19(23,24)25/h3-4,7-10H,5-6H2,1H3,(H2,27,28,29,30,31,32)	OQCGRHOQNOOHFP-UHFFFAOYSA-N	280048	US10028961, Compound 201::US10172864, Compound 201	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280048	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280048&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124000502	378161598							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533739	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)-c2ccccc2)n1	InChI=1S/C25H20F5N7/c26-24(27)11-9-17(14-24)33-23-36-21(18-7-4-8-20(34-18)25(28,29)30)35-22(37-23)32-16-10-12-31-19(13-16)15-5-2-1-3-6-15/h1-8,10,12-13,17H,9,11,14H2,(H2,31,32,33,35,36,37)	WBCWQBKLLSFRCG-UHFFFAOYSA-N	280049	US10028961, Compound 202::US10172864, Compound 202::US10946023, Compound 202	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280049	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280049&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798716	378161599							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533741	C[C@@H](Nc1nc(NC(C)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C17H18F6N6/c1-8(10-6-7-10)24-14-27-13(11-4-3-5-12(26-11)17(21,22)23)28-15(29-14)25-9(2)16(18,19)20/h3-5,8-10H,6-7H2,1-2H3,(H2,24,25,27,28,29)/t8-,9?/m1/s1	AFJDSJYOWKPURG-VEDVMXKPSA-N	280050	US10028961, Compound 203::US10172864, Compound 203::US10946023, Compound 203	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280050	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280050&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817231	378161600							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533745	FC(F)c1csc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H22F6N6S/c20-13(21)12-9-32-15(28-12)14-29-16(26-10-1-5-18(22,23)6-2-10)31-17(30-14)27-11-3-7-19(24,25)8-4-11/h9-11,13H,1-8H2,(H2,26,27,29,30,31)	KXYSDNWDMNWMPI-UHFFFAOYSA-N	280052	US10028961, Compound 205::US10172864, Compound 205::US10946023, Compound 205	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280052	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280052&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817472	378161602							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533748	C[C@@H](Nc1nc(Nc2ccnc(c2)C#N)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C16H11F6N9/c1-8(15(17,18)19)25-12-27-13(26-9-2-4-24-10(6-9)7-23)29-14(28-12)31-5-3-11(30-31)16(20,21)22/h2-6,8H,1H3,(H2,24,25,26,27,28,29)/t8-/m1/s1	WPINTHZUZYAPQF-MRVPVSSYSA-N	280054	US10028961, Compound 207::US10172864, Compound 207::US10946023, Compound 207	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280054	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280054&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817469	378161604							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533751	CC(F)(F)c1nc(cs1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H16F6N6S/c1-14(17,18)11-25-9(6-29-11)10-26-12(23-7-2-15(19,20)3-7)28-13(27-10)24-8-4-16(21,22)5-8/h6-8H,2-5H2,1H3,(H2,23,24,26,27,28)	RGHZRMLVPJRYFM-UHFFFAOYSA-N	280056	US10028961, Compound 209::US10172864, Compound 209::US10946023, Compound 209	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280056	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280056&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817148	378161606							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533753	FC(F)(F)c1ccn(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C17H12F5N9/c18-16(19)6-11(7-16)26-14-27-13(25-9-1-3-24-10(5-9)8-23)28-15(29-14)31-4-2-12(30-31)17(20,21)22/h1-5,11H,6-7H2,(H2,24,25,26,27,28,29)	UDPIYDLIPGHOFT-UHFFFAOYSA-N	280057	US10028961, Compound 210::US10172864, Compound 210::US10946023, Compound 210	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280057	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280057&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799025	378161607							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533755	CC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C25H24F4N8/c1-23(26,27)18-4-2-3-17(34-18)20-35-21(32-15-5-8-25(28,29)9-6-15)37-22(36-20)33-16-7-12-31-19(13-16)24(14-30)10-11-24/h2-4,7,12-13,15H,5-6,8-11H2,1H3,(H2,31,32,33,35,36,37)	QRMZPBWPZWIROS-UHFFFAOYSA-N	280058	US10028961, Compound 211::US10172864, Compound 211::US10946023, Compound 211	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280058	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280058&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817159	378161608							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533757	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(Cl)n1	InChI=1S/C20H23ClF4N6/c21-15-3-1-2-14(28-15)16-29-17(26-12-4-8-19(22,23)9-5-12)31-18(30-16)27-13-6-10-20(24,25)11-7-13/h1-3,12-13H,4-11H2,(H2,26,27,29,30,31)	UIBBMCJNFUASJY-UHFFFAOYSA-N	280059	US10028961, Compound 212::US10172864, Compound 212::US10946023, Compound 212	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280059	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280059&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817149	378161609							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533759	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C19H13F5N8/c20-18(21)7-12(8-18)28-17-31-15(13-2-1-3-14(29-13)19(22,23)24)30-16(32-17)27-10-4-5-26-11(6-10)9-25/h1-6,12H,7-8H2,(H2,26,27,28,30,31,32)	RQRJJSVAJSUINU-UHFFFAOYSA-N	280060	US10028961, Compound 213::US10172864, Compound 213::US10946023, Compound 213	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280060	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280060&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817155	378161610							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533761	CC(CC#N)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C18H20F3N7/c1-10(8-9-22)23-16-26-15(13-4-3-5-14(25-13)18(19,20)21)27-17(28-16)24-11(2)12-6-7-12/h3-5,10-12H,6-8H2,1-2H3,(H2,23,24,26,27,28)/t10?,11-/m1/s1	IFMDZJNJPFFCSK-RRKGBCIJSA-N	280061	US10028961, Compound 214::US10172864, Compound 214::US10946023, Compound 214	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280061	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280061&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799309	378161611							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533763	FC(F)(F)CNc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-c1cccc(Cl)n1	InChI=1S/C19H14ClF3N8/c1-24-18(6-7-18)13-9-11(5-8-25-13)27-17-30-15(12-3-2-4-14(20)28-12)29-16(31-17)26-10-19(21,22)23/h2-5,8-9H,6-7,10H2,(H2,25,26,27,29,30,31)	RJYPNTZBJZUSPV-UHFFFAOYSA-N	280062	US10028961, Compound 215::US10172864, Compound 215	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280062	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280062&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124015477	378161612							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533765	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC(F)(F)C2)nc(NCC2CC(F)(F)C2)n1	InChI=1S/C19H19F7N6/c20-17(21)4-10(5-17)8-27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-9-11-6-18(22,23)7-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	OSLHWFZOOADJCB-UHFFFAOYSA-N	280063	US10028961, Compound 216::US10172864, Compound 216::US10946023, Compound 216	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280063	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280063&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817178	378161613							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533767	CC(Nc1nc(Nc2ccnc(c2)-c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C23H17F6N7/c1-13(22(24,25)26)31-20-34-19(16-8-5-9-18(33-16)23(27,28)29)35-21(36-20)32-15-10-11-30-17(12-15)14-6-3-2-4-7-14/h2-13H,1H3,(H2,30,31,32,34,35,36)	NWTISIXHXPIMSM-UHFFFAOYSA-N	280064	US10028961, Compound 217::US10172864, Compound 217::US10946023, Compound 217	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280064	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280064&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817152	378161614							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533771	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)-c2ccccc2)n1	InChI=1S/C26H22F5N7/c27-25(28)12-9-17(10-13-25)33-23-36-22(19-7-4-8-21(35-19)26(29,30)31)37-24(38-23)34-18-11-14-32-20(15-18)16-5-2-1-3-6-16/h1-8,11,14-15,17H,9-10,12-13H2,(H2,32,33,34,36,37,38)	WTQROKONFNCZLX-UHFFFAOYSA-N	280067	US10028961, Compound 220::US10172864, Compound 220::US10946023, Compound 220	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280067	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280067&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798796	378161617							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533773	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H15F8N7/c21-18(22)7-10(8-18)9-30-16-33-15(12-2-1-3-13(32-12)19(23,24)25)34-17(35-16)31-11-4-5-29-14(6-11)20(26,27)28/h1-6,10H,7-9H2,(H2,29,30,31,33,34,35)	OWAVUCAENWNGFB-UHFFFAOYSA-N	280068	US10028961, Compound 221::US10172864, Compound 221::US10946023, Compound 221	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280068	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280068&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799308	378161618							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533775	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)c2ccccn2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C23H23F5N8/c24-22(25)9-7-14(12-22)30-20-33-19(16-4-3-5-17(32-16)23(26,27)28)34-21(35-20)31-15-8-11-36(13-15)18-6-1-2-10-29-18/h1-6,10,14-15H,7-9,11-13H2,(H2,30,31,33,34,35)	TYLCUGJKUXBFOZ-UHFFFAOYSA-N	280069	US10028961, Compound 222::US10172864, Compound 222::US10946023, Compound 222	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280069	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280069&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817038	378161619							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533777	FC(F)(F)c1nc(cs1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H21F7N6S/c20-17(21)5-1-10(2-6-17)27-15-30-13(12-9-33-14(29-12)19(24,25)26)31-16(32-15)28-11-3-7-18(22,23)8-4-11/h9-11H,1-8H2,(H2,27,28,30,31,32)	PFTFOLWIPCINKJ-UHFFFAOYSA-N	280070	US10028961, Compound 223::US10172864, Compound 223::US10946023, Compound 223	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280070	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280070&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817026	378161620							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533779	FC(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H24F6N6/c22-16(23)14-2-1-3-15(30-14)17-31-18(28-12-4-8-20(24,25)9-5-12)33-19(32-17)29-13-6-10-21(26,27)11-7-13/h1-3,12-13,16H,4-11H2,(H2,28,29,31,32,33)	VPZNRBLRTQODKB-UHFFFAOYSA-N	280071	US10028961, Compound 224::US10172864, Compound 224::US10946023, Compound 224	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280071	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280071&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817029	378161621							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533782	FC(F)(F)CNc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H14F6N8/c1-27-18(6-7-18)14-9-11(5-8-28-14)30-17-33-15(32-16(34-17)29-10-19(21,22)23)12-3-2-4-13(31-12)20(24,25)26/h2-5,8-9H,6-7,10H2,(H2,28,29,30,32,33,34)	PFZLERVPZNDZDD-UHFFFAOYSA-N	280073	US10028961, Compound 226::US10172864, Compound 226	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280073	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280073&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123942898	378161623							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533784	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)c2ncccn2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C22H22F5N9/c23-21(24)7-5-13(11-21)30-18-33-17(15-3-1-4-16(32-15)22(25,26)27)34-19(35-18)31-14-6-10-36(12-14)20-28-8-2-9-29-20/h1-4,8-9,13-14H,5-7,10-12H2,(H2,30,31,33,34,35)	YPXQHURHYKDPKF-UHFFFAOYSA-N	280074	US10028961, Compound 227::US10172864, Compound 227::US10946023, Compound 227	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280074	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280074&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817030	378161624							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533787	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C25H21F5N8/c1-31-23(6-7-23)18-9-14(5-8-32-18)33-20-36-19(16-3-2-4-17(35-16)25(28,29)30)37-21(38-20)34-15-10-22(11-15)12-24(26,27)13-22/h2-5,8-9,15H,6-7,10-13H2,(H2,32,33,34,36,37,38)	QOYBVQHDVXHECC-UHFFFAOYSA-N	280076	US10028961, Compound 229::US10172864, Compound 229	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280076	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280076&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123245946	378161626							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533790	CC(C)(CC#N)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C21H19F5N8/c1-19(2,8-9-27)34-18-32-16(13-5-4-6-14(30-13)21(24,25)26)31-17(33-18)29-12-7-10-28-15(11-12)20(3,22)23/h4-7,10-11H,8H2,1-3H3,(H2,28,29,31,32,33,34)	BFTBMPMZGISYIU-UHFFFAOYSA-N	280078	US10028961, Compound 231::US10172864, Compound 231::US10946023, Compound 231	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280078	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280078&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117800590	378161628							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533792	FC(F)(F)CNc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C17H10F9N7/c18-15(19,20)7-28-13-31-12(9-2-1-3-10(30-9)16(21,22)23)32-14(33-13)29-8-4-5-27-11(6-8)17(24,25)26/h1-6H,7H2,(H2,27,28,29,31,32,33)	PLCJHAPDBYLXRZ-UHFFFAOYSA-N	280079	US10028961, Compound 232::US10172864, Compound 232::US10946023, Compound 232	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280079	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280079&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817637	378161629							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533794	C[C@@H](Nc1nc(NC2C3CC4CC(C3)CC2C4)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C24H29F3N6/c1-12(15-5-6-15)28-22-31-21(18-3-2-4-19(29-18)24(25,26)27)32-23(33-22)30-20-16-8-13-7-14(10-16)11-17(20)9-13/h2-4,12-17,20H,5-11H2,1H3,(H2,28,30,31,32,33)/t12-,13?,14?,16?,17?,20?/m1/s1	IQUHQOIQGCZYCW-FGSOGITGSA-N	280081	US10028961, Compound 234::US10172864, Compound 234::US10946023, Compound 234	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280081	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280081&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			122440897	378161631							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533797	CC(C)(O)CNc1nc(Nc2cc(F)cc(Cl)c2)nc(n1)-c1cccc(n1)C(C)(F)F	InChI=1S/C20H20ClF3N6O/c1-19(2,31)10-25-17-28-16(14-5-4-6-15(27-14)20(3,23)24)29-18(30-17)26-13-8-11(21)7-12(22)9-13/h4-9,31H,10H2,1-3H3,(H2,25,26,28,29,30)	OCYNITMCPHUSLK-UHFFFAOYSA-N	280083	US10028961, Compound 236::US10172864, Compound 236::US10946023, Compound 236	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280083	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280083&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817133	378161633							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533798	FC(F)(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H18F7N7/c19-16(20)4-1-9(7-16)27-14-30-13(12-26-6-3-11(29-12)18(23,24)25)31-15(32-14)28-10-2-5-17(21,22)8-10/h3,6,9-10H,1-2,4-5,7-8H2,(H2,27,28,30,31,32)	KWUXKJRKEMYSCZ-UHFFFAOYSA-N	280084	US10028961, Compound 237::US10172864, Compound 237::US10946023, Compound 237	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280084	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280084&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817165	378161634							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533800	FC(F)(F)c1cccc(n1)-c1nc(NC2CN(C2)c2ccccn2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C22H21F5N8/c23-21(24)8-7-13(10-21)29-19-32-18(15-4-3-5-16(31-15)22(25,26)27)33-20(34-19)30-14-11-35(12-14)17-6-1-2-9-28-17/h1-6,9,13-14H,7-8,10-12H2,(H2,29,30,32,33,34)	ZBGLZSWJEQJJBZ-UHFFFAOYSA-N	280085	US10028961, Compound 238::US10172864, Compound 238::US10946023, Compound 238	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280085	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280085&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817186	378161635							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533802	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(N[C@@H]2CN(C(=O)C2)c2ccccn2)n1	InChI=1S/C23H21F5N8O/c24-22(25)8-7-13(11-22)30-20-33-19(15-4-3-5-16(32-15)23(26,27)28)34-21(35-20)31-14-10-18(37)36(12-14)17-6-1-2-9-29-17/h1-6,9,13-14H,7-8,10-12H2,(H2,30,31,33,34,35)/t13?,14-/m0/s1	JXQUUPVCXHTUAY-KZUDCZAMSA-N	280086	US10028961, Compound 239::US10172864, Compound 239::US10946023, Compound 239	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280086	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280086&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817437	378161636							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533804	CC(C)OCC(C)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H27F3N6O/c1-11(2)30-10-12(3)24-18-27-17(15-6-5-7-16(26-15)20(21,22)23)28-19(29-18)25-13(4)14-8-9-14/h5-7,11-14H,8-10H2,1-4H3,(H2,24,25,27,28,29)/t12?,13-/m1/s1	HNZFJEZPGBZOCO-ZGTCLIOFSA-N	280088	US10028961, Compound 241::US10172864, Compound 241::US10946023, Compound 241	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280088	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280088&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817568	378161638							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533806	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccc(cc3C2)C#N)n1	InChI=1S/C24H20F5N7/c25-23(26)7-6-16(11-23)31-21-34-20(18-2-1-3-19(33-18)24(27,28)29)35-22(36-21)32-17-9-14-5-4-13(12-30)8-15(14)10-17/h1-5,8,16-17H,6-7,9-11H2,(H2,31,32,34,35,36)	TXAOJZZVXLZXJJ-UHFFFAOYSA-N	280089	US10028961, Compound 242::US10172864, Compound 242::US10946023, Compound 242	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280089	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280089&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817436	378161639							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533807	FC(F)(F)c1cccc(n1)-c1nc(NC2CN(C2)c2cccnc2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C22H21F5N8/c23-21(24)7-6-13(9-21)29-19-32-18(16-4-1-5-17(31-16)22(25,26)27)33-20(34-19)30-14-11-35(12-14)15-3-2-8-28-10-15/h1-5,8,10,13-14H,6-7,9,11-12H2,(H2,29,30,32,33,34)	MOFOELJBPOCBKQ-UHFFFAOYSA-N	280090	US10028961, Compound 243::US10172864, Compound 243::US10946023, Compound 243	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280090	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280090&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817396	378161640							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533813	C[C@@H](Nc1nc(NCCOc2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C22H23F3N6O/c1-14(15-10-11-15)27-21-30-19(17-8-5-9-18(28-17)22(23,24)25)29-20(31-21)26-12-13-32-16-6-3-2-4-7-16/h2-9,14-15H,10-13H2,1H3,(H2,26,27,29,30,31)/t14-/m1/s1	YVNVAIVKELSNHE-CQSZACIVSA-N	280093	US10028961, Compound 246::US10172864, Compound 246::US10946023, Compound 246	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280093	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280093&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817294	378161643							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533815	CC(C)(Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C20H17F5N8/c1-18(2,10-26)33-17-31-15(12-5-4-6-13(29-12)20(23,24)25)30-16(32-17)28-11-7-8-27-14(9-11)19(3,21)22/h4-9H,1-3H3,(H2,27,28,30,31,32,33)	BDJHMJRZDMMMSY-UHFFFAOYSA-N	280094	US10028961, Compound 247::US10172864, Compound 247::US10946023, Compound 247	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280094	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280094&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799111	378161644							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533818	Nc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H24F5N7/c21-13-1-2-14(26)29-15(13)16-30-17(27-11-3-7-19(22,23)8-4-11)32-18(31-16)28-12-5-9-20(24,25)10-6-12/h1-2,11-12H,3-10H2,(H2,26,29)(H2,27,28,30,31,32)	AHCWVZUQCYWTLX-UHFFFAOYSA-N	280096	US10028961, Compound 249::US10172864, Compound 249::US10946023, Compound 249	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280096	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280096&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799328	378161646							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533820	CC(CC#N)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H17F5N8/c1-11(6-8-26)28-17-31-16(13-4-3-5-14(30-13)20(23,24)25)32-18(33-17)29-12-7-9-27-15(10-12)19(2,21)22/h3-5,7,9-11H,6H2,1-2H3,(H2,27,28,29,31,32,33)	KFKFZAMDAKZTOH-UHFFFAOYSA-N	280097	US10028961, Compound 250::US10172864, Compound 250::US10946023, Compound 250	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280097	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280097&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117800753	378161647							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533823	FC(F)(F)c1nccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H14F7N7/c17-14(18)3-7(4-14)25-12-28-10(9-1-2-24-11(27-9)16(21,22)23)29-13(30-12)26-8-5-15(19,20)6-8/h1-2,7-8H,3-6H2,(H2,25,26,28,29,30)	YXRZGIVPZUGDBI-UHFFFAOYSA-N	280098	US10028961, Compound 251::US10172864, Compound 251::US10946023, Compound 251	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280098	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280098&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817045	378161648							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533825	FC(F)(F)Oc1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C19H19F7N6O/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)33-19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	MQELCCGCZSQGHW-UHFFFAOYSA-N	280099	US10028961, Compound 252::US10172864, Compound 252::US10946023, Compound 252	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280099	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280099&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817037	378161649							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533827	CC(Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C19H15F5N8/c1-10(9-25)27-16-30-15(12-4-3-5-13(29-12)19(22,23)24)31-17(32-16)28-11-6-7-26-14(8-11)18(2,20)21/h3-8,10H,1-2H3,(H2,26,27,28,30,31,32)	DOYNKYWVGHFSIP-UHFFFAOYSA-N	280100	US10028961, Compound 253::US10172864, Compound 253::US10946023, Compound 253	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280100	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280100&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799196	378161650							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533830	FC(F)(F)c1cccc(n1)-c1nc(NC2CCOCC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H23F5N6O/c21-19(22)8-4-12(5-9-19)26-17-29-16(14-2-1-3-15(28-14)20(23,24)25)30-18(31-17)27-13-6-10-32-11-7-13/h1-3,12-13H,4-11H2,(H2,26,27,29,30,31)	XOGJBAWBFBEDJT-UHFFFAOYSA-N	280102	US10028961, Compound 255::US10172864, Compound 255::US10946023, Compound 255	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280102	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280102&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817036	378161652							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533832	FC(F)(F)c1ccnc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H14F7N7/c17-14(18)3-7(4-14)25-12-28-11(10-24-2-1-9(27-10)16(21,22)23)29-13(30-12)26-8-5-15(19,20)6-8/h1-2,7-8H,3-6H2,(H2,25,26,28,29,30)	FPHDGFLOXFTVGJ-UHFFFAOYSA-N	280103	US10028961, Compound 256::US10172864, Compound 256::US10946023, Compound 256	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280103	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280103&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817034	378161653							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533834	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C22H17F8N7/c23-20(24)9-19(10-20)7-12(8-19)33-18-36-16(13-2-1-3-14(34-13)21(25,26)27)35-17(37-18)32-11-4-5-31-15(6-11)22(28,29)30/h1-6,12H,7-10H2,(H2,31,32,33,35,36,37)	BTPLBROFKCBOEI-UHFFFAOYSA-N	280104	US10028961, Compound 257::US10172864, Compound 257::US10946023, Compound 257	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280104	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280104&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799484	378161654							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533835	FC(F)(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C22H18F5N9/c23-21(24)4-1-13(10-21)32-19-35-17(16-30-8-3-14(33-16)22(25,26)27)34-18(36-19)31-12-2-7-29-15(9-12)20(11-28)5-6-20/h2-3,7-9,13H,1,4-6,10H2,(H2,29,31,32,34,35,36)	NQLUCGNQWCNNAV-UHFFFAOYSA-N	280108	US10028961, Compound 261::US10172864, Compound 261::US10946023, Compound 261	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280108	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280108&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799322	378161658							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533837	C[C@@H](Nc1nc(NCC(C)(C)C#N)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C19H22F3N7/c1-11(12-7-8-12)25-17-28-15(13-5-4-6-14(26-13)19(20,21)22)27-16(29-17)24-10-18(2,3)9-23/h4-6,11-12H,7-8,10H2,1-3H3,(H2,24,25,27,28,29)/t11-/m1/s1	YMYMOIAVHSSRHV-LLVKDONJSA-N	280109	US10028961, Compound 262::US10172864, Compound 262::US10946023, Compound 262	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280109	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280109&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817189	378161659							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533839	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)C(=O)c2ccccc2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C25H24F5N7O/c26-24(27)11-9-16(13-24)31-22-34-20(18-7-4-8-19(33-18)25(28,29)30)35-23(36-22)32-17-10-12-37(14-17)21(38)15-5-2-1-3-6-15/h1-8,16-17H,9-14H2,(H2,31,32,34,35,36)	IGICKZPCOKPPMZ-UHFFFAOYSA-N	280110	US10028961, Compound 263::US10172864, Compound 263::US10946023, Compound 263	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280110	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280110&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817170	378161660							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533841	CC(C)(O)CNc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C18H21F5N6O/c1-16(2,30)9-24-14-27-13(11-4-3-5-12(26-11)18(21,22)23)28-15(29-14)25-10-6-7-17(19,20)8-10/h3-5,10,30H,6-9H2,1-2H3,(H2,24,25,27,28,29)	BBXPSOCEABWQQG-UHFFFAOYSA-N	280111	US10028961, Compound 264::US10172864, Compound 264::US10946023, Compound 264	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280111	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280111&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817169	378161661							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533843	FC1(F)CC2(CC(C2)Nc2nc(NC3CC4(C3)CC(F)(F)C4)nc(n2)-c2cccc(Cl)n2)C1	InChI=1S/C22H23ClF4N6/c23-15-3-1-2-14(30-15)16-31-17(28-12-4-19(5-12)8-21(24,25)9-19)33-18(32-16)29-13-6-20(7-13)10-22(26,27)11-20/h1-3,12-13H,4-11H2,(H2,28,29,31,32,33)	PBFHHOMGSNGWEC-UHFFFAOYSA-N	280112	US10028961, Compound 265::US10172864, Compound 265::US10946023, Compound 265	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280112	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280112&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817162	378161662							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533845	CS(=O)(=O)N1CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C21H26F5N7O2S/c1-36(34,35)33-11-7-14(8-12-33)28-19-31-17(15-3-2-4-16(29-15)21(24,25)26)30-18(32-19)27-13-5-9-20(22,23)10-6-13/h2-4,13-14H,5-12H2,1H3,(H2,27,28,30,31,32)	XMCNRFYMKPJZQG-UHFFFAOYSA-N	280113	US10028961, Compound 266::US10172864, Compound 266::US10946023, Compound 266	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280113	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280113&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817164	378161663							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533848	CC(C)(CNc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C21H19F5N8/c1-19(2,10-27)11-29-17-32-16(13-5-4-6-14(31-13)21(24,25)26)33-18(34-17)30-12-7-8-28-15(9-12)20(3,22)23/h4-9H,11H2,1-3H3,(H2,28,29,30,32,33,34)	LWUOICMGVABMMB-UHFFFAOYSA-N	280114	US10028961, Compound 267::US10172864, Compound 267::US10946023, Compound 267	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280114	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280114&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117800203	378161664							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533850	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1nccc(n1)C(F)(F)F)C1CC1	InChI=1S/C18H22F3N7/c1-9(11-3-4-11)23-16-26-15(14-22-8-7-13(25-14)18(19,20)21)27-17(28-16)24-10(2)12-5-6-12/h7-12H,3-6H2,1-2H3,(H2,23,24,26,27,28)/t9-,10-/m1/s1	DDVPWDBXRXZEBC-NXEZZACHSA-N	280115	US10028961, Compound 268::US10172864, Compound 268::US10946023, Compound 268	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280115	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280115&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817172	378161665							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533853	FC(F)(F)c1nccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F7N7/c21-18(22)6-1-11(2-7-18)29-16-32-14(13-5-10-28-15(31-13)20(25,26)27)33-17(34-16)30-12-3-8-19(23,24)9-4-12/h5,10-12H,1-4,6-9H2,(H2,29,30,32,33,34)	VFDBHGHEXPAMBP-UHFFFAOYSA-N	280117	US10028961, Compound 270::US10172864, Compound 270::US10946023, Compound 270	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280117	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280117&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817589	378161667							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533854	CC(CC#N)Nc1nc(NC(C)C[N+]#[C-])nc(n1)-c1cccc(Cl)n1	InChI=1S/C16H17ClN8/c1-10(7-8-18)20-15-23-14(12-5-4-6-13(17)22-12)24-16(25-15)21-11(2)9-19-3/h4-6,10-11H,7,9H2,1-2H3,(H2,20,21,23,24,25)	DPKMJIDGQOHGGQ-UHFFFAOYSA-N	280118	US10028961, Compound 271::US10172864, Compound 271	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280118	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280118&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124023000	378161668							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533856	Fc1ccc(cc1)[C@@H]1C[C@@H](C1)Nc1nc(N[C@H]2C[C@H](C2)c2ccc(F)cc2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C29H25F5N6/c30-20-8-4-16(5-9-20)18-12-22(13-18)35-27-38-26(24-2-1-3-25(37-24)29(32,33)34)39-28(40-27)36-23-14-19(15-23)17-6-10-21(31)11-7-17/h1-11,18-19,22-23H,12-15H2,(H2,35,36,38,39,40)/t18-,19-,22+,23+	NMLSZZYWTRQLTB-MBEIMAIZSA-N	280119	US10028961, Compound 272::US10172864, Compound 272::US10946023, Compound 272	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280119	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280119&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817318	378161669							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533857	CC(=O)N1CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C22H26F5N7O/c1-13(35)34-11-7-15(8-12-34)29-20-32-18(16-3-2-4-17(30-16)22(25,26)27)31-19(33-20)28-14-5-9-21(23,24)10-6-14/h2-4,14-15H,5-12H2,1H3,(H2,28,29,31,32,33)	PVZIUYNREPTYEJ-UHFFFAOYSA-N	280120	US10028961, Compound 273::US10172864, Compound 273::US10946023, Compound 273	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280120	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280120&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817549	378161670							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533859	CC(C)(C)OC(=O)N1CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C25H32F5N7O2/c1-23(2,3)39-22(38)37-13-9-16(10-14-37)32-21-35-19(17-5-4-6-18(33-17)25(28,29)30)34-20(36-21)31-15-7-11-24(26,27)12-8-15/h4-6,15-16H,7-14H2,1-3H3,(H2,31,32,34,35,36)	MMAPFCIIBGUZQG-UHFFFAOYSA-N	280121	US10028961, Compound 274::US10172864, Compound 274::US10946023, Compound 274	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280121	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280121&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817557	378161671							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533861	Cn1cc(c(n1)C(F)(F)F)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H24F7N7/c1-34-10-13(14(33-34)20(25,26)27)15-30-16(28-11-2-6-18(21,22)7-3-11)32-17(31-15)29-12-4-8-19(23,24)9-5-12/h10-12H,2-9H2,1H3,(H2,28,29,30,31,32)	MZFAUIFIADPAFR-UHFFFAOYSA-N	280122	US10028961, Compound 275::US10172864, Compound 275::US10946023, Compound 275	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280122	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280122&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817548	378161672							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533862	Fc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F6N6/c21-13-1-2-14(22)29-15(13)16-30-17(27-11-3-7-19(23,24)8-4-11)32-18(31-16)28-12-5-9-20(25,26)10-6-12/h1-2,11-12H,3-10H2,(H2,27,28,30,31,32)	PKVKJUWOHXPGCE-UHFFFAOYSA-N	280123	US10028961, Compound 276::US10172864, Compound 276::US10946023, Compound 276	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280123	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280123&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799150	378161673							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533863	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-n1cc(I)cn1)C1CC1	InChI=1S/C16H22IN7/c1-9(11-3-4-11)19-14-21-15(20-10(2)12-5-6-12)23-16(22-14)24-8-13(17)7-18-24/h7-12H,3-6H2,1-2H3,(H2,19,20,21,22,23)/t9-,10-/m1/s1	XKHRDUPMIXLGTD-NXEZZACHSA-N	280126	US10028961, Compound 279::US10172864, Compound 279::US10946023, Compound 279	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280126	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280126&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817477	378161676							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533864	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(Cc3ccccc3)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C25H26F5N7/c26-24(27)11-9-17(13-24)31-22-34-21(19-7-4-8-20(33-19)25(28,29)30)35-23(36-22)32-18-10-12-37(15-18)14-16-5-2-1-3-6-16/h1-8,17-18H,9-15H2,(H2,31,32,34,35,36)	UWVLIFBOSBPFON-UHFFFAOYSA-N	280127	US10028961, Compound 280::US10172864, Compound 280::US10946023, Compound 280	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280127	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280127&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817414	378161677							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533866	CC(F)(F)c1nc(cs1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H24F6N6S/c1-18(21,22)15-29-13(10-33-15)14-30-16(27-11-2-6-19(23,24)7-3-11)32-17(31-14)28-12-4-8-20(25,26)9-5-12/h10-12H,2-9H2,1H3,(H2,27,28,30,31,32)	BCVWBQGSHAGBJM-UHFFFAOYSA-N	280130	US10028961, Compound 283::US10172864, Compound 283::US10946023, Compound 283	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280130	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280130&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817484	378161680							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533867	CC(C)(O)CNc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H23F5N6O/c1-17(2,31)10-25-15-28-14(12-4-3-5-13(27-12)19(22,23)24)29-16(30-15)26-11-6-8-18(20,21)9-7-11/h3-5,11,31H,6-10H2,1-2H3,(H2,25,26,28,29,30)	IWJRYKAPBRKGLL-UHFFFAOYSA-N	280134	US10028961, Compound 287::US10172864, Compound 287::US10946023, Compound 287	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280134	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280134&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817444	378161684							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533868	CC(C)(C)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C19H19F5N8/c1-17(2,3)32-16-30-14(13-26-8-6-11(28-13)19(22,23)24)29-15(31-16)27-10-5-7-25-12(9-10)18(4,20)21/h5-9H,1-4H3,(H2,25,27,29,30,31,32)	VVDJVXUCSQFDNF-UHFFFAOYSA-N	280136	US10028961, Compound 289::US10172864, Compound 289::US10946023, Compound 289	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280136	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280136&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817459	378161686							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533870	FC(F)(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F7N7/c21-18(22)6-1-11(2-7-18)29-16-32-15(14-28-10-5-13(31-14)20(25,26)27)33-17(34-16)30-12-3-8-19(23,24)9-4-12/h5,10-12H,1-4,6-9H2,(H2,29,30,32,33,34)	MDCZNBIZILVZSF-UHFFFAOYSA-N	280140	US10028961, Compound 293::US10172864, Compound 293::US10946023, Compound 293	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280140	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280140&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817463	378161690							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533872	FC(F)(F)Oc1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H23F7N6O/c22-19(23)8-4-12(5-9-19)29-17-32-16(14-2-1-3-15(31-14)35-21(26,27)28)33-18(34-17)30-13-6-10-20(24,25)11-7-13/h1-3,12-13H,4-11H2,(H2,29,30,32,33,34)	HSAOXCHGPDCXKT-UHFFFAOYSA-N	280143	US10028961, Compound 296::US10172864, Compound 296::US10946023, Compound 296	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280143	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280143&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817462	378161693							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533873	FC(F)(F)c1n[nH]cc1-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H22F7N7/c20-17(21)5-1-10(2-6-17)28-15-30-14(12-9-27-33-13(12)19(24,25)26)31-16(32-15)29-11-3-7-18(22,23)8-4-11/h9-11H,1-8H2,(H,27,33)(H2,28,29,30,31,32)	WYHVNJNVMROQBY-UHFFFAOYSA-N	280144	US10028961, Compound 297::US10172864, Compound 297::US10946023, Compound 297	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280144	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280144&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817464	378161694							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533874	CC(C)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C18H17F5N8/c1-9(2)26-15-29-14(13-25-7-5-11(28-13)18(21,22)23)30-16(31-15)27-10-4-6-24-12(8-10)17(3,19)20/h4-9H,1-3H3,(H2,24,26,27,29,30,31)	MNWAUMZTPYXVGO-UHFFFAOYSA-N	280145	US10028961, Compound 298::US10172864, Compound 298::US10946023, Compound 298	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280145	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280145&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798710	378161695							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533876	Cc1nc(co1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H16F4N6O/c1-7-20-10(6-26-7)11-23-12(21-8-2-14(16,17)3-8)25-13(24-11)22-9-4-15(18,19)5-9/h6,8-9H,2-5H2,1H3,(H2,21,22,23,24,25)	YBHPSBQYBQRDEV-UHFFFAOYSA-N	280148	US10028961, Compound 301::US10172864, Compound 301::US10946023, Compound 301	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280148	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280148&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817319	378161698							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533877	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-n1cc(Cl)cn1	InChI=1S/C18H22ClF4N7/c19-11-9-24-30(10-11)16-28-14(25-12-1-5-17(20,21)6-2-12)27-15(29-16)26-13-3-7-18(22,23)8-4-13/h9-10,12-13H,1-8H2,(H2,25,26,27,28,29)	QSWMJNNVEMLNDB-UHFFFAOYSA-N	280149	US10028961, Compound 302::US10172864, Compound 302::US10946023, Compound 302	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280149	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280149&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817332	378161699							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533879	FC(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H23F6N7/c21-14(22)13-5-10-27-15(30-13)16-31-17(28-11-1-6-19(23,24)7-2-11)33-18(32-16)29-12-3-8-20(25,26)9-4-12/h5,10-12,14H,1-4,6-9H2,(H2,28,29,31,32,33)	KCKMAAKVFCQNEN-UHFFFAOYSA-N	280155	US10028961, Compound 308::US10172864, Compound 308::US10946023, Compound 308	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280155	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280155&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466270	378161705							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533881	Oc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H23F5N6O/c21-13-1-2-14(32)28-15(13)16-29-17(26-11-3-7-19(22,23)8-4-11)31-18(30-16)27-12-5-9-20(24,25)10-6-12/h1-2,11-12H,3-10H2,(H,28,32)(H2,26,27,29,30,31)	LBPUKFIAHANDDC-UHFFFAOYSA-N	280156	US10028961, Compound 309::US10172864, Compound 309::US10946023, Compound 309	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280156	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280156&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799124	378161706							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533882	Cc1cc(no1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H16F4N6O/c1-7-2-10(25-26-7)11-22-12(20-8-3-14(16,17)4-8)24-13(23-11)21-9-5-15(18,19)6-9/h2,8-9H,3-6H2,1H3,(H2,20,21,22,23,24)	JWLFPLOMUNYBLN-UHFFFAOYSA-N	280158	US10028961, Compound 311::US10172864, Compound 311::US10946023, Compound 311	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280158	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280158&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817411	378161708							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533883	COCCc1ccnc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C22H29F4N7O/c1-34-13-7-16-6-12-27-17(28-16)18-31-19(29-14-2-8-21(23,24)9-3-14)33-20(32-18)30-15-4-10-22(25,26)11-5-15/h6,12,14-15H,2-5,7-11,13H2,1H3,(H2,29,30,31,32,33)	IIDRMKULCOPTDM-UHFFFAOYSA-N	280162	US10028961, Compound 315::US10172864, Compound 315::US10946023, Compound 315	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280162	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280162&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466269	378161712							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533884	Cc1nc(c[nH]1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H17F4N7/c1-7-20-6-10(21-7)11-24-12(22-8-2-14(16,17)3-8)26-13(25-11)23-9-4-15(18,19)5-9/h6,8-9H,2-5H2,1H3,(H,20,21)(H2,22,23,24,25,26)	LRORKNAAPJYJSX-UHFFFAOYSA-N	280164	US10028961, Compound 317::US10172864, Compound 317::US10946023, Compound 317	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280164	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280164&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817555	378161714							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533886	Cc1nc(c[nH]1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1			280166	US10028961, Compound 319::US10172864, Compound 319::US10946023, Compound 319	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280166	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280166&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817325	378161716							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533887	COc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H25F5N6O/c1-33-15-3-2-14(22)16(29-15)17-30-18(27-12-4-8-20(23,24)9-5-12)32-19(31-17)28-13-6-10-21(25,26)11-7-13/h2-3,12-13H,4-11H2,1H3,(H2,27,28,30,31,32)	PUYRUGBORWDDDV-UHFFFAOYSA-N	280168	US10028961, Compound 321::US10172864, Compound 321::US10946023, Compound 321	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280168	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280168&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817329	378161718							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533889	Cc1nsc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C18H23F4N7S/c1-10-23-14(30-29-10)13-26-15(24-11-2-6-17(19,20)7-3-11)28-16(27-13)25-12-4-8-18(21,22)9-5-12/h11-12H,2-9H2,1H3,(H2,24,25,26,27,28)	YGASMFPIDZFMKN-UHFFFAOYSA-N	280175	US10028961, Compound 328::US10172864, Compound 328::US10946023, Compound 328	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280175	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280175&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817331	378161724							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533890	Cc1nc(c[nH]1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H25F4N7/c1-11-24-10-14(25-11)15-28-16(26-12-2-6-18(20,21)7-3-12)30-17(29-15)27-13-4-8-19(22,23)9-5-13/h10,12-13H,2-9H2,1H3,(H,24,25)(H2,26,27,28,29,30)	OMGWTZOTCFNMGJ-UHFFFAOYSA-N	280179	US10028961, Compound 332::US10172864, Compound 332::US10946023, Compound 332	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280179	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280179&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817562	378161728							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533891	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1nc(ns1)-c1ccccc1	InChI=1S/C23H25F4N7S/c24-22(25)10-6-15(7-11-22)28-20-31-18(19-30-17(34-35-19)14-4-2-1-3-5-14)32-21(33-20)29-16-8-12-23(26,27)13-9-16/h1-5,15-16H,6-13H2,(H2,28,29,31,32,33)	VEBDQVKKCIRACB-UHFFFAOYSA-N	280180	US10028961, Compound 333::US10172864, Compound 333::US10946023, Compound 333	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280180	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280180&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817500	378161729							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533892	C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C15H13F9N6/c1-6(13(16,17)18)25-11-28-10(8-4-3-5-9(27-8)15(22,23)24)29-12(30-11)26-7(2)14(19,20)21/h3-7H,1-2H3,(H2,25,26,28,29,30)/t6-,7-/m1/s1	QTNDXEZBEFRYER-RNFRBKRXSA-N	280263	US10028961, Compound 335::US10172864, Compound 335::US10946023, Compound 335	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280263	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280263&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817551	378161812							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533894	C[C@@H](Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cncc(n1)C(F)F)C(F)(F)F	InChI=1S/C20H16F5N9/c1-10(20(23,24)25)29-17-32-16(13-8-27-7-12(31-13)15(21)22)33-18(34-17)30-11-2-5-28-14(6-11)19(9-26)3-4-19/h2,5-8,10,15H,3-4H2,1H3,(H2,28,29,30,32,33,34)/t10-/m1/s1	XRIMCXRSOOURPD-SNVBAGLBSA-N	280264	US10028961, Compound 336::US10946023, Compound 336	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280264	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280264&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817587	378161813							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533896	C[C@H](Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cncc(n1)C(F)F)C(F)(F)F	InChI=1S/C20H16F5N9/c1-10(20(23,24)25)29-17-32-16(13-8-27-7-12(31-13)15(21)22)33-18(34-17)30-11-2-5-28-14(6-11)19(9-26)3-4-19/h2,5-8,10,15H,3-4H2,1H3,(H2,28,29,30,32,33,34)/t10-/m0/s1	XRIMCXRSOOURPD-JTQLQIEISA-N	280265	US10028961, Compound 337::US10946023, Compound 337	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280265	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280265&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817592	378161814							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533898	FC(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C23H21F4N9/c24-18(25)15-10-29-11-16(33-15)19-34-20(31-13-1-4-23(26,27)5-2-13)36-21(35-19)32-14-3-8-30-17(9-14)22(12-28)6-7-22/h3,8-11,13,18H,1-2,4-7H2,(H2,30,31,32,34,35,36)	URNJUUSCJUDDRL-UHFFFAOYSA-N	280266	US10028961, Compound 338::US10946023, Compound 338	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280266	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280266&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799078	378161815							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533900	CC[C@H](Nc1nc(N[C@@H](CC)C(F)(F)F)nc(n1)-c1cncc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C16H16F9N7/c1-3-8(14(17,18)19)28-12-30-11(7-5-26-6-10(27-7)16(23,24)25)31-13(32-12)29-9(4-2)15(20,21)22/h5-6,8-9H,3-4H2,1-2H3,(H2,28,29,30,31,32)/t8-,9-/m0/s1	PVRJPVONIMLLSK-IUCAKERBSA-N	280181	US10028961, Compound 339::US10172864, Compound 339::US10946023, Compound 339	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280181	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280181&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817364	378161730							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533902	FC(F)(F)c1cc(Nc2nc(N[C@@H]3CCC(F)(F)C3)nc(n2)-c2ccnc(n2)C(F)(F)F)ccn1	InChI=1S/C19H14F8N8/c20-17(21)4-1-10(8-17)31-16-34-13(11-3-6-29-14(32-11)19(25,26)27)33-15(35-16)30-9-2-5-28-12(7-9)18(22,23)24/h2-3,5-7,10H,1,4,8H2,(H2,28,30,31,33,34,35)/t10-/m1/s1	AZYHZXGJDLEMHT-SNVBAGLBSA-N	280182	US10028961, Compound 340::US10172864, Compound 340::US10946023, Compound 340	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280182	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280182&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799016	378161731							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533904	FC(F)(F)c1nccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C22H18F5N9/c1-28-20(6-7-20)15-10-12(3-8-29-15)31-18-34-16(14-4-9-30-17(33-14)22(25,26)27)35-19(36-18)32-13-2-5-21(23,24)11-13/h3-4,8-10,13H,2,5-7,11H2,(H2,29,31,32,34,35,36)/t13-/m0/s1	BMSFMFUPGRCJSV-ZDUSSCGKSA-N	280183	US10028961, Compound 341::US10172864, Compound 341	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280183	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280183&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123266135	378161732							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533906	FC(F)(F)c1nccc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C22H18F5N9/c1-28-20(6-7-20)15-10-12(3-8-29-15)31-18-34-16(14-4-9-30-17(33-14)22(25,26)27)35-19(36-18)32-13-2-5-21(23,24)11-13/h3-4,8-10,13H,2,5-7,11H2,(H2,29,31,32,34,35,36)/t13-/m1/s1	BMSFMFUPGRCJSV-CYBMUJFWSA-N	280184	US10028961, Compound 342::US10172864, Compound 342	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280184	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280184&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123855153	378161733							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533908	FC(F)(F)c1cc(Nc2nc(N[C@H]3CCC(F)(F)C3)nc(n2)-c2ccnc(n2)C(F)(F)F)ccn1	InChI=1S/C19H14F8N8/c20-17(21)4-1-10(8-17)31-16-34-13(11-3-6-29-14(32-11)19(25,26)27)33-15(35-16)30-9-2-5-28-12(7-9)18(22,23)24/h2-3,5-7,10H,1,4,8H2,(H2,28,30,31,33,34,35)/t10-/m0/s1	AZYHZXGJDLEMHT-JTQLQIEISA-N	280185	US10028961, Compound 343::US10172864, Compound 343::US10946023, Compound 343	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280185	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280185&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799117	378161734							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533909	C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1ccnc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C14H12F9N7/c1-5(12(15,16)17)25-10-28-8(7-3-4-24-9(27-7)14(21,22)23)29-11(30-10)26-6(2)13(18,19)20/h3-6H,1-2H3,(H2,25,26,28,29,30)/t5-,6-/m1/s1	OKFOLQBIBWUZIG-PHDIDXHHSA-N	280186	US10028961, Compound 344::US10172864, Compound 344::US10946023, Compound 344	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280186	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280186&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817545	378161735							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533911	CC[C@H](Nc1nc(N[C@@H](CC)C(F)(F)F)nc(n1)-c1ccnc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C16H16F9N7/c1-3-8(14(17,18)19)28-12-30-10(7-5-6-26-11(27-7)16(23,24)25)31-13(32-12)29-9(4-2)15(20,21)22/h5-6,8-9H,3-4H2,1-2H3,(H2,28,29,30,31,32)/t8-,9-/m0/s1	BAHJVQDALFYMEG-IUCAKERBSA-N	280187	US10028961, Compound 345::US10172864, Compound 345::US10946023, Compound 345	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280187	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280187&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817569	378161736							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533913	CC[C@H](Nc1nc(N[C@@H](CC)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C17H17F9N6/c1-3-9(15(18,19)20)28-13-30-12(8-6-5-7-11(27-8)17(24,25)26)31-14(32-13)29-10(4-2)16(21,22)23/h5-7,9-10H,3-4H2,1-2H3,(H2,28,29,30,31,32)/t9-,10-/m0/s1	QTQWJQDDICMREO-UWVGGRQHSA-N	280188	US10028961, Compound 346::US10172864, Compound 346::US10946023, Compound 346	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280188	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280188&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817580	378161737							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533915	C[C@H](Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(n1)C(C)(F)F)C(F)(F)F	InChI=1S/C22H19F5N8/c1-12(22(25,26)27)30-18-33-17(14-4-3-5-15(32-14)20(2,23)24)34-19(35-18)31-13-6-9-29-16(10-13)21(11-28)7-8-21/h3-6,9-10,12H,7-8H2,1-2H3,(H2,29,30,31,33,34,35)/t12-/m0/s1	WLTAGDRBXBZXAG-LBPRGKRZSA-N	280189	US10028961, Compound 347::US10946023, Compound 347	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280189	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280189&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799048	378161738							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533917	C[C@@H](Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(n1)C(C)(F)F)C(F)(F)F	InChI=1S/C22H19F5N8/c1-12(22(25,26)27)30-18-33-17(14-4-3-5-15(32-14)20(2,23)24)34-19(35-18)31-13-6-9-29-16(10-13)21(11-28)7-8-21/h3-6,9-10,12H,7-8H2,1-2H3,(H2,29,30,31,33,34,35)/t12-/m1/s1	WLTAGDRBXBZXAG-GFCCVEGCSA-N	280190	US10028961, Compound 348::US10946023, Compound 348	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280190	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280190&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799159	378161739							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533919	C[C@H](Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C19H15F6N9/c1-10(18(20,21)22)28-14-30-15(29-11-2-6-27-13(8-11)17(9-26)4-5-17)32-16(31-14)34-7-3-12(33-34)19(23,24)25/h2-3,6-8,10H,4-5H2,1H3,(H2,27,28,29,30,31,32)/t10-/m0/s1	VXRYLBWUODLCCR-JTQLQIEISA-N	280191	US10028961, Compound 349::US10946023, Compound 349	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280191	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280191&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817454	378161740							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533921	FC(F)(F)c1ccn(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C21H18F5N9/c22-20(23)4-1-13(10-20)30-17-31-16(29-12-2-7-28-15(9-12)19(11-27)5-6-19)32-18(33-17)35-8-3-14(34-35)21(24,25)26/h2-3,7-9,13H,1,4-6,10H2,(H2,28,29,30,31,32,33)/t13-/m1/s1	WFGLMCWPQJGAJJ-CYBMUJFWSA-N	280192	US10028961, Compound 350::US10946023, Compound 350	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280192&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799289	378161741							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533922	FC(F)(F)c1ccn(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C21H18F5N9/c22-20(23)4-1-13(10-20)30-17-31-16(29-12-2-7-28-15(9-12)19(11-27)5-6-19)32-18(33-17)35-8-3-14(34-35)21(24,25)26/h2-3,7-9,13H,1,4-6,10H2,(H2,28,29,30,31,32,33)/t13-/m1/s1	WFGLMCWPQJGAJJ-CYBMUJFWSA-N	280192	US10028961, Compound 350::US10946023, Compound 350	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280192&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799289	378161741							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533925	C[C@H](Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C21H16F6N8/c1-11(20(22,23)24)30-17-33-16(13-3-2-4-14(32-13)21(25,26)27)34-18(35-17)31-12-5-8-29-15(9-12)19(10-28)6-7-19/h2-5,8-9,11H,6-7H2,1H3,(H2,29,30,31,33,34,35)/t11-/m0/s1	HJCRKYCQHOQKKS-NSHDSACASA-N	280193	US10028961, Compound 351::US10172864, Compound 351::US10946023, Compound 351	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280193	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280193&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817486	378161742							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533927	C[C@@H](Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C21H16F6N8/c1-11(20(22,23)24)30-17-33-16(13-3-2-4-14(32-13)21(25,26)27)34-18(35-17)31-12-5-8-29-15(9-12)19(10-28)6-7-19/h2-5,8-9,11H,6-7H2,1H3,(H2,29,30,31,33,34,35)/t11-/m1/s1	HJCRKYCQHOQKKS-LLVKDONJSA-N	280194	US10028961, Compound 352::US10172864, Compound 352::US10946023, Compound 352	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280194	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280194&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817489	378161743							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533929	FC(F)(F)c1csc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C18H13F8N7S/c19-16(20)3-1-9(6-16)29-15-32-12(13-30-11(7-34-13)18(24,25)26)31-14(33-15)28-8-2-4-27-10(5-8)17(21,22)23/h2,4-5,7,9H,1,3,6H2,(H2,27,28,29,31,32,33)	AQQOIBQYLSHDSV-UHFFFAOYSA-N	280195	US10028961, Compound 353::US10172864, Compound 353::US10946023, Compound 353	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280195	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280195&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817453	378161744							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533931	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC2(F)F)nc(NCC2CC2(F)F)n1	InChI=1S/C17H15F7N6/c18-15(19)4-8(15)6-25-13-28-12(10-2-1-3-11(27-10)17(22,23)24)29-14(30-13)26-7-9-5-16(9,20)21/h1-3,8-9H,4-7H2,(H2,25,26,28,29,30)	XHKYLNZMSNXADF-UHFFFAOYSA-N	280196	US10028961, Compound 354::US10172864, Compound 354::US10946023, Compound 354	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280196	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280196&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817488	378161745							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533933	CC(F)(F)c1cc(Nc2nc(N[C@@H]3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)ccn1	InChI=1S/C21H18F7N7/c1-19(22,23)15-9-11(6-8-29-15)30-17-33-16(13-3-2-4-14(32-13)21(26,27)28)34-18(35-17)31-12-5-7-20(24,25)10-12/h2-4,6,8-9,12H,5,7,10H2,1H3,(H2,29,30,31,33,34,35)/t12-/m1/s1	RJZGABPOSOZJRY-GFCCVEGCSA-N	280197	US10028961, Compound 355::US10172864, Compound 355::US10946023, Compound 355	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280197	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280197&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799376	378161746							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533935	C[C@H](Nc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C16H11F9N8/c1-7(14(17,18)19)27-11-29-12(28-8-2-4-26-10(6-8)16(23,24)25)31-13(30-11)33-5-3-9(32-33)15(20,21)22/h2-7H,1H3,(H2,26,27,28,29,30,31)/t7-/m0/s1	ORPDRKJAHZEOLR-ZETCQYMHSA-N	280198	US10028961, Compound 356::US10172864, Compound 356::US10946023, Compound 356	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280198	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280198&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817491	378161747							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533937	CC(F)(F)c1csc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H24F6N6S/c1-18(21,22)13-10-33-15(29-13)14-30-16(27-11-2-6-19(23,24)7-3-11)32-17(31-14)28-12-4-8-20(25,26)9-5-12/h10-12H,2-9H2,1H3,(H2,27,28,30,31,32)	SPXMCXYDNWDRAD-UHFFFAOYSA-N	280199	US10028961, Compound 357::US10946023, Compound 357	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280199	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280199&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817487	378161748							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533939	CC(F)(F)c1cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)ccn1	InChI=1S/C20H16F7N7/c1-18(21,22)14-7-10(5-6-28-14)29-16-32-15(12-3-2-4-13(31-12)20(25,26)27)33-17(34-16)30-11-8-19(23,24)9-11/h2-7,11H,8-9H2,1H3,(H2,28,29,30,32,33,34)	NBLZOFNGJDPRRM-UHFFFAOYSA-N	280200	US10028961, Compound 358::US10172864, Compound 358::US10946023, Compound 358	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280200	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280200&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817563	378161749							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533941	C[C@@H](Nc1nc(Nc2ccnc(c2)-c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C23H17F6N7/c1-13(22(24,25)26)31-20-34-19(16-8-5-9-18(33-16)23(27,28)29)35-21(36-20)32-15-10-11-30-17(12-15)14-6-3-2-4-7-14/h2-13H,1H3,(H2,30,31,32,34,35,36)/t13-/m1/s1	NWTISIXHXPIMSM-CYBMUJFWSA-N	280201	US10028961, Compound 359::US10172864, Compound 359::US10946023, Compound 359	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280201	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280201&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799238	378161750							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533943	CC(F)(F)c1cc(Nc2nc(N[C@H]3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)ccn1	InChI=1S/C21H18F7N7/c1-19(22,23)15-9-11(6-8-29-15)30-17-33-16(13-3-2-4-14(32-13)21(26,27)28)34-18(35-17)31-12-5-7-20(24,25)10-12/h2-4,6,8-9,12H,5,7,10H2,1H3,(H2,29,30,31,33,34,35)/t12-/m0/s1	RJZGABPOSOZJRY-LBPRGKRZSA-N	280202	US10028961, Compound 360::US10172864, Compound 360::US10946023, Compound 360	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280202	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280202&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799001	378161751							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533945	CC(F)(F)c1cc(Nc2nc(NC3CCC(F)(F)CC3)nc(n2)-c2cccc(n2)C(F)(F)F)ccn1	InChI=1S/C22H20F7N7/c1-20(23,24)16-11-13(7-10-30-16)32-19-35-17(14-3-2-4-15(33-14)22(27,28)29)34-18(36-19)31-12-5-8-21(25,26)9-6-12/h2-4,7,10-12H,5-6,8-9H2,1H3,(H2,30,31,32,34,35,36)	RSCDXFNMGRWMJK-UHFFFAOYSA-N	280203	US10028961, Compound 361::US10172864, Compound 361::US10946023, Compound 361	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280203	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280203&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799134	378161752							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533947	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC2(F)F)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C22H17F5N8/c23-21(24)9-12(21)10-30-18-33-17(14-2-1-3-15(32-14)22(25,26)27)34-19(35-18)31-13-4-7-29-16(8-13)20(11-28)5-6-20/h1-4,7-8,12H,5-6,9-10H2,(H2,29,30,31,33,34,35)	UHAUZFGASUNLGF-UHFFFAOYSA-N	280204	US10028961, Compound 362::US10946023, Compound 362	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280204	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280204&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817591	378161753							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533948	CC[C@H](Nc1nc(N[C@@H](CC)C(F)(F)F)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C15H16F9N7/c1-3-7(13(16,17)18)25-10-27-11(26-8(4-2)14(19,20)21)29-12(28-10)31-6-5-9(30-31)15(22,23)24/h5-8H,3-4H2,1-2H3,(H2,25,26,27,28,29)/t7-,8-/m0/s1	CNPVZLAVEHNGOP-YUMQZZPRSA-N	280205	US10028961, Compound 363::US10172864, Compound 363::US10946023, Compound 363	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280205	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280205&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817560	378161754							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533950	C[C@@H](Nc1nc(Nc2ccnc(c2)-c2ccc(Cl)cc2)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C23H16ClF6N7/c1-12(22(25,26)27)32-20-35-19(16-3-2-4-18(34-16)23(28,29)30)36-21(37-20)33-15-9-10-31-17(11-15)13-5-7-14(24)8-6-13/h2-12H,1H3,(H2,31,32,33,35,36,37)/t12-/m1/s1	IETQZYOXYCRTPQ-GFCCVEGCSA-N	280206	US10028961, Compound 364::US10172864, Compound 364::US10946023, Compound 364	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280206	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280206&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799131	378161755							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533952	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC2(F)F)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C19H13F8N7/c20-17(21)7-9(17)8-29-15-32-14(11-2-1-3-12(31-11)18(22,23)24)33-16(34-15)30-10-4-5-28-13(6-10)19(25,26)27/h1-6,9H,7-8H2,(H2,28,29,30,32,33,34)	JSIARFQDVBMCLB-UHFFFAOYSA-N	280207	US10028961, Compound 365::US10172864, Compound 365::US10946023, Compound 365	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280207	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280207&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798965	378161756							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533954	CC(F)(F)c1cncc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C17H17F6N7/c1-15(18,19)11-7-24-6-10(27-11)12-28-13(25-8-2-16(20,21)3-8)30-14(29-12)26-9-4-17(22,23)5-9/h6-9H,2-5H2,1H3,(H2,25,26,28,29,30)	CDUYLYBNWORMLM-UHFFFAOYSA-N	280208	US10028961, Compound 366::US10172864, Compound 366::US10946023, Compound 366	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280208	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280208&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817559	378161757							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533956	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)CC3)nc(n2)-c2cncc(n2)C(F)(F)F)c1	InChI=1S/C20H16F7N7/c21-10-5-11(22)7-13(6-10)30-18-33-16(14-8-28-9-15(31-14)20(25,26)27)32-17(34-18)29-12-1-3-19(23,24)4-2-12/h5-9,12H,1-4H2,(H2,29,30,32,33,34)	CUSSJQLSJJSNTA-UHFFFAOYSA-N	280209	US10028961, Compound 367::US10172864, Compound 367::US10946023, Compound 367	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280209	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280209&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817564	378161758							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533958	Fc1cc(F)cc(Nc2nc(N[C@H]3CCC(F)(F)C3)nc(n2)-c2cncc(n2)C(F)(F)F)c1	InChI=1S/C19H14F7N7/c20-9-3-10(21)5-12(4-9)29-17-32-15(13-7-27-8-14(30-13)19(24,25)26)31-16(33-17)28-11-1-2-18(22,23)6-11/h3-5,7-8,11H,1-2,6H2,(H2,28,29,31,32,33)/t11-/m0/s1	ZPNAECASCHOTOG-NSHDSACASA-N	280210	US10028961, Compound 368::US10172864, Compound 368::US10946023, Compound 368	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280210	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280210&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817404	378161759							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533959	Fc1cc(F)cc(Nc2nc(N[C@H]3CCC(F)(F)C3)nc(n2)-c2cncc(n2)C(F)(F)F)c1	InChI=1S/C19H14F7N7/c20-9-3-10(21)5-12(4-9)29-17-32-15(13-7-27-8-14(30-13)19(24,25)26)31-16(33-17)28-11-1-2-18(22,23)6-11/h3-5,7-8,11H,1-2,6H2,(H2,28,29,31,32,33)/t11-/m0/s1	ZPNAECASCHOTOG-NSHDSACASA-N	280210	US10028961, Compound 368::US10172864, Compound 368::US10946023, Compound 368	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280210	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280210&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817404	378161759							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533961	Fc1cc(F)cc(Nc2nc(N[C@@H]3CCC(F)(F)C3)nc(n2)-c2cncc(n2)C(F)(F)F)c1	InChI=1S/C19H14F7N7/c20-9-3-10(21)5-12(4-9)29-17-32-15(13-7-27-8-14(30-13)19(24,25)26)31-16(33-17)28-11-1-2-18(22,23)6-11/h3-5,7-8,11H,1-2,6H2,(H2,28,29,31,32,33)/t11-/m1/s1	ZPNAECASCHOTOG-LLVKDONJSA-N	280211	US10028961, Compound 369::US10172864, Compound 369::US10946023, Compound 369	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280211	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280211&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817407	378161760							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533963	CC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C19H21F6N7/c1-17(20,21)13-9-26-8-12(29-13)14-30-15(27-10-2-4-18(22,23)6-10)32-16(31-14)28-11-3-5-19(24,25)7-11/h8-11H,2-7H2,1H3,(H2,27,28,30,31,32)	HZKDADBLQPSIOY-UHFFFAOYSA-N	280212	US10028961, Compound 370::US10172864, Compound 370::US10946023, Compound 370	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280212	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280212&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817403	378161761							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533965	C[C@@H](Nc1nc(Nc2ccnc(c2)-c2ccc(F)cc2)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C23H16F7N7/c1-12(22(25,26)27)32-20-35-19(16-3-2-4-18(34-16)23(28,29)30)36-21(37-20)33-15-9-10-31-17(11-15)13-5-7-14(24)8-6-13/h2-12H,1H3,(H2,31,32,33,35,36,37)/t12-/m1/s1	AIVPAWKVFHFNSZ-GFCCVEGCSA-N	280213	US10028961, Compound 371::US10172864, Compound 371::US10946023, Compound 371	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280213	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280213&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799215	378161762							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533967	CC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C23H20F4N8/c1-21(24,25)16-4-2-3-15(32-16)18-33-19(35-20(34-18)31-14-10-23(26,27)11-14)30-13-5-8-29-17(9-13)22(12-28)6-7-22/h2-5,8-9,14H,6-7,10-11H2,1H3,(H2,29,30,31,33,34,35)	RTZBPKFZOQGNAS-UHFFFAOYSA-N	280214	US10028961, Compound 372::US10172864, Compound 372::US10946023, Compound 372	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280214	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280214&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799242	378161763							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533969	FC(F)(F)c1cncc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C22H18F5N9/c1-28-20(5-6-20)15-8-12(3-7-30-15)31-18-34-17(14-10-29-11-16(33-14)22(25,26)27)35-19(36-18)32-13-2-4-21(23,24)9-13/h3,7-8,10-11,13H,2,4-6,9H2,(H2,30,31,32,34,35,36)/t13-/m0/s1	HMXVERBLXZDCDV-ZDUSSCGKSA-N	280215	US10028961, Compound 373::US10172864, Compound 373	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280215	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280215&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123990677	378161764							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533971	CC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H25F6N7/c1-19(22,23)15-11-28-10-14(31-15)16-32-17(29-12-2-6-20(24,25)7-3-12)34-18(33-16)30-13-4-8-21(26,27)9-5-13/h10-13H,2-9H2,1H3,(H2,29,30,32,33,34)	IXEKFWPZLJDVJT-UHFFFAOYSA-N	280216	US10028961, Compound 374::US10172864, Compound 374::US10946023, Compound 374	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280216	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280216&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817406	378161765							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533973	FC(F)(F)c1ccnc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C22H18F5N9/c23-21(24)4-1-13(10-21)32-19-35-17(16-30-8-3-14(33-16)22(25,26)27)34-18(36-19)31-12-2-7-29-15(9-12)20(11-28)5-6-20/h2-3,7-9,13H,1,4-6,10H2,(H2,29,31,32,34,35,36)/t13-/m1/s1	NQLUCGNQWCNNAV-CYBMUJFWSA-N	280217	US10028961, Compound 375::US10172864, Compound 375::US10946023, Compound 375	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280217	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280217&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			122440956	378161766							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533975	FC(F)(F)c1ccnc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C22H18F5N9/c23-21(24)4-1-13(10-21)32-19-35-17(16-30-8-3-14(33-16)22(25,26)27)34-18(36-19)31-12-2-7-29-15(9-12)20(11-28)5-6-20/h2-3,7-9,13H,1,4-6,10H2,(H2,29,31,32,34,35,36)/t13-/m0/s1	NQLUCGNQWCNNAV-ZDUSSCGKSA-N	280218	US10028961, Compound 376::US10172864, Compound 376::US10946023, Compound 376	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>1000					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280218	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280218&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799341	378161767							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533976	C[C@@H](Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cncc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C20H15F6N9/c1-10(19(21,22)23)30-16-33-15(12-7-28-8-14(32-12)20(24,25)26)34-17(35-16)31-11-2-5-29-13(6-11)18(9-27)3-4-18/h2,5-8,10H,3-4H2,1H3,(H2,29,30,31,33,34,35)/t10-/m1/s1	UOBJQCXKMFJOJP-SNVBAGLBSA-N	280219	US10028961, Compound 377::US10946023, Compound 377	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280219&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817408	378161768							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533978	FC(F)(F)c1cncc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C22H18F5N9/c23-21(24)3-1-13(8-21)32-19-35-17(14-9-29-10-16(33-14)22(25,26)27)34-18(36-19)31-12-2-6-30-15(7-12)20(11-28)4-5-20/h2,6-7,9-10,13H,1,3-5,8H2,(H2,30,31,32,34,35,36)/t13-/m1/s1	XGRJPWINIPKAGC-CYBMUJFWSA-N	280220	US10028961, Compound 378::US10946023, Compound 378	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280220&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799189	378161769							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533980	FC(F)(F)c1csc(n1)-c1nc(NCC2CC2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C17H13F6N7S/c18-16(19,20)10-5-9(3-4-24-10)26-15-29-12(13-27-11(7-31-13)17(21,22)23)28-14(30-15)25-6-8-1-2-8/h3-5,7-8H,1-2,6H2,(H2,24,25,26,28,29,30)	KUPZRBAQHZPHES-UHFFFAOYSA-N	280221	US10028961, Compound 379::US10172864, Compound 379::US10946023, Compound 379	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280221&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817130	378161770							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533982	FC(F)(F)c1cncc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C21H16F8N8/c22-19(23)8-18(9-19)4-11(5-18)33-17-36-15(12-6-30-7-14(34-12)21(27,28)29)35-16(37-17)32-10-1-2-31-13(3-10)20(24,25)26/h1-3,6-7,11H,4-5,8-9H2,(H2,31,32,33,35,36,37)	UQNYKCNMQIBEFQ-UHFFFAOYSA-N	280222	US10028961, Compound 380::US10172864, Compound 380::US10946023, Compound 380	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280222	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280222&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799022	378161771							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533984	FC(F)(F)c1ccn(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C18H14F5N9/c19-17(20)4-1-11(8-17)27-15-28-14(26-10-2-5-25-12(7-10)9-24)29-16(30-15)32-6-3-13(31-32)18(21,22)23/h2-3,5-7,11H,1,4,8H2,(H2,25,26,27,28,29,30)/t11-/m0/s1	LUJOXCPZQNCMMB-NSHDSACASA-N	280223	US10028961, Compound 381::US10172864, Compound 381::US10946023, Compound 381	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280223&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817181	378161772							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533986	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C22H20F5N9/c1-28-20(8-9-20)16-12-14(4-10-29-16)31-18-32-17(30-13-2-6-21(23,24)7-3-13)33-19(34-18)36-11-5-15(35-36)22(25,26)27/h4-5,10-13H,2-3,6-9H2,(H2,29,30,31,32,33,34)	JTVHZHFBVAULDV-UHFFFAOYSA-N	280224	US10028961, Compound 382::US10172864, Compound 382	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280224	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280224&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123605512	378161773							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533987	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C22H20F5N9/c1-28-20(8-9-20)16-12-14(4-10-29-16)31-18-32-17(30-13-2-6-21(23,24)7-3-13)33-19(34-18)36-11-5-15(35-36)22(25,26)27/h4-5,10-13H,2-3,6-9H2,(H2,29,30,31,32,33,34)	JTVHZHFBVAULDV-UHFFFAOYSA-N	280224	US10028961, Compound 382::US10172864, Compound 382	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280224	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280224&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123605512	378161773							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533989	C[C@@H](Nc1nc(Nc2ccnc(c2)-c2ccc(cc2)[N+]#[C-])nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C24H16F6N8/c1-13(23(25,26)27)33-21-36-20(17-4-3-5-19(35-17)24(28,29)30)37-22(38-21)34-16-10-11-32-18(12-16)14-6-8-15(31-2)9-7-14/h3-13H,1H3,(H2,32,33,34,36,37,38)/t13-/m1/s1	GEJISPDXPBOJLP-CYBMUJFWSA-N	280225	US10028961, Compound 383::US10172864, Compound 383	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280225	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280225&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123590184	378161774							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533991	CC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C24H22F4N8/c1-22(25,26)17-4-2-3-16(33-17)19-34-20(36-21(35-19)32-15-5-7-24(27,28)12-15)31-14-6-10-30-18(11-14)23(13-29)8-9-23/h2-4,6,10-11,15H,5,7-9,12H2,1H3,(H2,30,31,32,34,35,36)	QUGNBYVSVJORNT-UHFFFAOYSA-N	280226	US10028961, Compound 384::US10172864, Compound 384::US10946023, Compound 384	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280226&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817179	378161775							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533993	FC(F)(F)c1cncc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C24H20F5N9/c25-23(26)10-21(11-23)6-14(7-21)34-20-37-18(15-8-31-9-17(35-15)24(27,28)29)36-19(38-20)33-13-1-4-32-16(5-13)22(12-30)2-3-22/h1,4-5,8-9,14H,2-3,6-7,10-11H2,(H2,32,33,34,36,37,38)	RFILWRLBMXUUTD-UHFFFAOYSA-N	280227	US10028961, Compound 385::US10172864, Compound 385::US10946023, Compound 385	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280227&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817131	378161776							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533995	C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cncc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C14H12F9N7/c1-5(12(15,16)17)25-10-28-9(7-3-24-4-8(27-7)14(21,22)23)29-11(30-10)26-6(2)13(18,19)20/h3-6H,1-2H3,(H2,25,26,28,29,30)/t5-,6-/m1/s1	WRRBNOCENGULOH-PHDIDXHHSA-N	280228	US10028961, Compound 386::US10172864, Compound 386::US10946023, Compound 386	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280228&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799027	378161777							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533997	FC(F)(F)c1cncc(n1)-c1nc(NCC2CC2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C18H14F6N8/c19-17(20,21)12-5-10(3-4-26-12)28-16-31-14(30-15(32-16)27-6-9-1-2-9)11-7-25-8-13(29-11)18(22,23)24/h3-5,7-9H,1-2,6H2,(H2,26,27,28,30,31,32)	FUVOVGXLXPPLTC-UHFFFAOYSA-N	280229	US10028961, Compound 387::US10172864, Compound 387::US10946023, Compound 387	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280229&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817183	378161778							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
533999	FC(F)(F)c1csc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C17H11F8N7S/c18-15(19)4-8(5-15)28-14-31-11(12-29-10(6-33-12)17(23,24)25)30-13(32-14)27-7-1-2-26-9(3-7)16(20,21)22/h1-3,6,8H,4-5H2,(H2,26,27,28,30,31,32)	FIHMFIIGBKKTHS-UHFFFAOYSA-N	280230	US10028961, Compound 388::US10172864, Compound 388::US10946023, Compound 388	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280230&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817151	378161779							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534001	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H16F8N8/c21-18(22)4-1-10(2-5-18)31-16-34-15(12-8-29-9-14(33-12)20(26,27)28)35-17(36-16)32-11-3-6-30-13(7-11)19(23,24)25/h3,6-10H,1-2,4-5H2,(H2,30,31,32,34,35,36)	DZAOGXHFTBFLFH-UHFFFAOYSA-N	280231	US10028961, Compound 389::US10172864, Compound 389::US10946023, Compound 389	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280231&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817166	378161780							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534002	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H16F8N8/c21-18(22)4-1-10(2-5-18)31-16-34-15(12-8-29-9-14(33-12)20(26,27)28)35-17(36-16)32-11-3-6-30-13(7-11)19(23,24)25/h3,6-10H,1-2,4-5H2,(H2,30,31,32,34,35,36)	DZAOGXHFTBFLFH-UHFFFAOYSA-N	280231	US10028961, Compound 389::US10172864, Compound 389::US10946023, Compound 389	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280231&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817166	378161780							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534005	FC(F)(F)c1cncc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C18H12F8N8/c19-16(20)4-9(5-16)30-15-33-13(10-6-27-7-12(31-10)18(24,25)26)32-14(34-15)29-8-1-2-28-11(3-8)17(21,22)23/h1-3,6-7,9H,4-5H2,(H2,28,29,30,32,33,34)	QQGZDIVDOFXSIU-UHFFFAOYSA-N	280232	US10028961, Compound 390::US10172864, Compound 390::US10946023, Compound 390	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280232	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280232&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799171	378161781							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534007	FC(F)(F)c1cncc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C19H14F8N8/c20-17(21)3-1-10(6-17)31-16-34-14(11-7-28-8-13(32-11)19(25,26)27)33-15(35-16)30-9-2-4-29-12(5-9)18(22,23)24/h2,4-5,7-8,10H,1,3,6H2,(H2,29,30,31,33,34,35)/t10-/m0/s1	ONCVYPCVWHYEJW-JTQLQIEISA-N	280233	US10028961, Compound 391::US10172864, Compound 391::US10946023, Compound 391	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280233&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799014	378161782							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534008	FC(F)(F)c1cncc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C19H14F8N8/c20-17(21)3-1-10(6-17)31-16-34-14(11-7-28-8-13(32-11)19(25,26)27)33-15(35-16)30-9-2-4-29-12(5-9)18(22,23)24/h2,4-5,7-8,10H,1,3,6H2,(H2,29,30,31,33,34,35)/t10-/m0/s1	ONCVYPCVWHYEJW-JTQLQIEISA-N	280233	US10028961, Compound 391::US10172864, Compound 391::US10946023, Compound 391	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280233&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799014	378161782							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534011	C[C@@H](Nc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C19H15F6N9/c1-10(18(20,21)22)28-14-30-15(29-11-3-7-27-13(9-11)17(26-2)5-6-17)32-16(31-14)34-8-4-12(33-34)19(23,24)25/h3-4,7-10H,5-6H2,1H3,(H2,27,28,29,30,31,32)/t10-/m1/s1	OQCGRHOQNOOHFP-SNVBAGLBSA-N	280234	US10028961, Compound 392::US10172864, Compound 392	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280234&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123157861	378161783							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534013	FC(F)(F)c1ccn(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C18H14F8N8/c19-16(20)4-1-10(8-16)29-14-30-13(28-9-2-5-27-12(7-9)18(24,25)26)31-15(32-14)34-6-3-11(33-34)17(21,22)23/h2-3,5-7,10H,1,4,8H2,(H2,27,28,29,30,31,32)/t10-/m0/s1	RACFSMUYWZWUMF-JTQLQIEISA-N	280235	US10028961, Compound 393::US10172864, Compound 393::US10946023, Compound 393	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280235&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799021	378161784							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534014	FC(F)(F)c1ccn(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C18H14F8N8/c19-16(20)4-1-10(8-16)29-14-30-13(28-9-2-5-27-12(7-9)18(24,25)26)31-15(32-14)34-6-3-11(33-34)17(21,22)23/h2-3,5-7,10H,1,4,8H2,(H2,27,28,29,30,31,32)/t10-/m0/s1	RACFSMUYWZWUMF-JTQLQIEISA-N	280235	US10028961, Compound 393::US10172864, Compound 393::US10946023, Compound 393	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280235&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799021	378161784							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534017	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C23H20F5N9/c1-29-21(7-8-21)16-10-14(4-9-31-16)33-20-36-18(15-11-30-12-17(34-15)23(26,27)28)35-19(37-20)32-13-2-5-22(24,25)6-3-13/h4,9-13H,2-3,5-8H2,(H2,31,32,33,35,36,37)	NZWQLAGSWXCELF-UHFFFAOYSA-N	280236	US10028961, Compound 394::US10172864, Compound 394	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280236	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280236&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123606255	378161785							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534019	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H21F7N6/c21-18(22)7-4-11(5-8-18)28-16-31-15(13-2-1-3-14(30-13)20(25,26)27)32-17(33-16)29-12-6-9-19(23,24)10-12/h1-3,11-12H,4-10H2,(H2,28,29,31,32,33)	TZKFRDJJAGMBLQ-UHFFFAOYSA-N	280237	US10028961, Compound 395::US10172864, Compound 395::US10946023, Compound 395	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280237&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817190	378161786							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534022	CC(C)(O)CNc1nc(Nc2cc(F)cc(c2)C(F)(F)F)nc(n1)-c1cccc(n1)C(C)(F)F	InChI=1S/C21H20F6N6O/c1-19(2,34)10-28-17-31-16(14-5-4-6-15(30-14)20(3,23)24)32-18(33-17)29-13-8-11(21(25,26)27)7-12(22)9-13/h4-9,34H,10H2,1-3H3,(H2,28,29,31,32,33)	ALWYCXBAKHGWLZ-UHFFFAOYSA-N	280238	US10028961, Compound 397::US10946023, Compound 397	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280238	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280238&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799347	378161787							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534023	CC(C)(O)CNc1nc(Nc2cc(F)cc(c2)C#N)nc(n1)-c1cccc(n1)C(C)(F)F	InChI=1S/C21H20F3N7O/c1-20(2,32)11-26-18-29-17(15-5-4-6-16(28-15)21(3,23)24)30-19(31-18)27-14-8-12(10-25)7-13(22)9-14/h4-9,32H,11H2,1-3H3,(H2,26,27,29,30,31)	VGNMNCNZHVXSEG-UHFFFAOYSA-N	280239	US10028961, Compound 398::US10946023, Compound 398	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280239	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280239&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799154	378161788							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534024	FC(F)(F)c1cncc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(N[C@@H]2CCC(F)(F)C2)n1	InChI=1S/C18H18F7N7/c19-16(20)3-1-9(5-16)27-14-30-13(11-7-26-8-12(29-11)18(23,24)25)31-15(32-14)28-10-2-4-17(21,22)6-10/h7-10H,1-6H2,(H2,27,28,30,31,32)/t9-,10+	YWUBJNPVIIBDPD-AOOOYVTPSA-N	280240	US10028961, Compound 399::US10172864, Compound 399::US10946023, Compound 399	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280240&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817142	378161789							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534026	C[C@@H](Nc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C16H11F9N8/c1-7(14(17,18)19)27-11-29-12(28-8-2-4-26-10(6-8)16(23,24)25)31-13(30-11)33-5-3-9(32-33)15(20,21)22/h2-7H,1H3,(H2,26,27,28,29,30,31)/t7-/m1/s1	ORPDRKJAHZEOLR-SSDOTTSWSA-N	280241	US10028961, Compound 400::US10172864, Compound 400::US10946023, Compound 400	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280241&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817128	378161790							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534027	C[C@@H](Nc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C16H11F9N8/c1-7(14(17,18)19)27-11-29-12(28-8-2-4-26-10(6-8)16(23,24)25)31-13(30-11)33-5-3-9(32-33)15(20,21)22/h2-7H,1H3,(H2,26,27,28,29,30,31)/t7-/m1/s1	ORPDRKJAHZEOLR-SSDOTTSWSA-N	280241	US10028961, Compound 400::US10172864, Compound 400::US10946023, Compound 400	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280241&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817128	378161790							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534030	FC(F)(F)c1cncc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C21H16F5N9/c22-20(23)6-12(7-20)31-18-34-16(13-8-28-9-15(32-13)21(24,25)26)33-17(35-18)30-11-1-4-29-14(5-11)19(10-27)2-3-19/h1,4-5,8-9,12H,2-3,6-7H2,(H2,29,30,31,33,34,35)	POVDFECNFQEJSG-UHFFFAOYSA-N	280242	US10028961, Compound 401::US10946023, Compound 401	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280242	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280242&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799510	378161791							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534031	FC(F)(F)c1cncc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C21H16F5N9/c22-20(23)6-12(7-20)31-18-34-16(13-8-28-9-15(32-13)21(24,25)26)33-17(35-18)30-11-1-4-29-14(5-11)19(10-27)2-3-19/h1,4-5,8-9,12H,2-3,6-7H2,(H2,29,30,31,33,34,35)	POVDFECNFQEJSG-UHFFFAOYSA-N	280242	US10028961, Compound 401::US10946023, Compound 401	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280242	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280242&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799510	378161791							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534034	FC(F)c1csc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C17H18F6N6S/c18-11(19)10-7-30-13(26-10)12-27-14(24-8-1-3-16(20,21)5-8)29-15(28-12)25-9-2-4-17(22,23)6-9/h7-9,11H,1-6H2,(H2,24,25,27,28,29)	VSPSEEIARINUPO-UHFFFAOYSA-N	280243	US10028961, Compound 402::US10172864, Compound 402::US10946023, Compound 402	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280243	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280243&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817157	378161792							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534036	FC(F)c1csc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H14F6N6S/c16-9(17)8-5-28-11(24-8)10-25-12(22-6-1-14(18,19)2-6)27-13(26-10)23-7-3-15(20,21)4-7/h5-7,9H,1-4H2,(H2,22,23,25,26,27)	GVVHKJZVVILBHY-UHFFFAOYSA-N	280244	US10028961, Compound 403::US10172864, Compound 403::US10946023, Compound 403	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280244&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817129	378161793							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534038	CC(Nc1nc(NC(C)C(F)(F)F)nc(n1)-c1nc(cs1)C(F)(F)F)C(F)(F)F	InChI=1S/C13H11F9N6S/c1-4(11(14,15)16)23-9-26-7(8-25-6(3-29-8)13(20,21)22)27-10(28-9)24-5(2)12(17,18)19/h3-5H,1-2H3,(H2,23,24,26,27,28)	HMRKPTGJADCEIY-UHFFFAOYSA-N	280245	US10028961, Compound 404::US10172864, Compound 404::US10946023, Compound 404	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280245	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280245&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817154	378161794							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534040	FC(F)(F)c1cncc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)c1	InChI=1S/C20H15F8N7/c21-18(22)5-4-11(7-18)30-16-33-15(13-2-1-3-14(32-13)20(26,27)28)34-17(35-16)31-12-6-10(8-29-9-12)19(23,24)25/h1-3,6,8-9,11H,4-5,7H2,(H2,30,31,33,34,35)	LRFCOIWENOAQEZ-UHFFFAOYSA-N	280246	US10028961, Compound 405::US10172864, Compound 405::US10946023, Compound 405	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280246	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280246&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799030	378161795							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534042	FC(F)(F)c1cncc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(N[C@H]2CCC(F)(F)C2)n1	InChI=1S/C18H18F7N7/c19-16(20)3-1-9(5-16)27-14-30-13(11-7-26-8-12(29-11)18(23,24)25)31-15(32-14)28-10-2-4-17(21,22)6-10/h7-10H,1-6H2,(H2,27,28,30,31,32)/t9-,10-/m0/s1	YWUBJNPVIIBDPD-UWVGGRQHSA-N	280247	US10028961, Compound 406::US10172864, Compound 406::US10946023, Compound 406	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280247	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280247&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817144	378161796							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534044	FC(F)(F)c1ccn(n1)-c1nc(NCC2CC2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C17H14F6N8/c18-16(19,20)11-4-6-31(30-11)15-28-13(25-8-9-1-2-9)27-14(29-15)26-10-3-5-24-12(7-10)17(21,22)23/h3-7,9H,1-2,8H2,(H2,24,25,26,27,28,29)	LMVUIUXDPQOTEI-UHFFFAOYSA-N	280248	US10028961, Compound 407::US10172864, Compound 407::US10946023, Compound 407	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280248	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280248&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798945	378161797							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534046	FC(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H19F6N7/c19-13(20)11-7-25-8-12(28-11)14-29-15(26-9-1-3-17(21,22)5-9)31-16(30-14)27-10-2-4-18(23,24)6-10/h7-10,13H,1-6H2,(H2,26,27,29,30,31)	IYNSADUHPNFIGN-UHFFFAOYSA-N	280249	US10028961, Compound 408::US10172864, Compound 408::US10946023, Compound 408	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280249	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280249&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817146	378161798							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534048	FC(F)c1cncc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H15F6N7/c17-11(18)9-5-23-6-10(26-9)12-27-13(24-7-1-15(19,20)2-7)29-14(28-12)25-8-3-16(21,22)4-8/h5-8,11H,1-4H2,(H2,24,25,27,28,29)	YIFYCTDCEXPZOP-UHFFFAOYSA-N	280250	US10028961, Compound 409::US10172864, Compound 409::US10946023, Compound 409	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280250	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280250&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817185	378161799							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534050	FC(F)(F)c1cncc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(N[C@@H]2CCC(F)(F)C2)n1	InChI=1S/C18H18F7N7/c19-16(20)3-1-9(5-16)27-14-30-13(11-7-26-8-12(29-11)18(23,24)25)31-15(32-14)28-10-2-4-17(21,22)6-10/h7-10H,1-6H2,(H2,27,28,30,31,32)/t9-,10-/m1/s1	YWUBJNPVIIBDPD-NXEZZACHSA-N	280251	US10028961, Compound 410::US10172864, Compound 410::US10946023, Compound 410	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280251	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280251&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817192	378161800							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534051	FC(F)(F)c1cncc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(N[C@@H]2CCC(F)(F)C2)n1	InChI=1S/C18H18F7N7/c19-16(20)3-1-9(5-16)27-14-30-13(11-7-26-8-12(29-11)18(23,24)25)31-15(32-14)28-10-2-4-17(21,22)6-10/h7-10H,1-6H2,(H2,27,28,30,31,32)/t9-,10-/m1/s1	YWUBJNPVIIBDPD-NXEZZACHSA-N	280251	US10028961, Compound 410::US10172864, Compound 410::US10946023, Compound 410	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280251	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280251&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817192	378161800							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534054	FC(F)c1ccnc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H15F6N7/c17-10(18)9-1-2-23-11(26-9)12-27-13(24-7-3-15(19,20)4-7)29-14(28-12)25-8-5-16(21,22)6-8/h1-2,7-8,10H,3-6H2,(H2,24,25,27,28,29)	YNUDPCHEAJUNPU-UHFFFAOYSA-N	280252	US10028961, Compound 411::US10172864, Compound 411::US10946023, Compound 411	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280252	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280252&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817193	378161801							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534056	FC(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H19F6N7/c19-12(20)11-3-6-25-13(28-11)14-29-15(26-9-1-4-17(21,22)7-9)31-16(30-14)27-10-2-5-18(23,24)8-10/h3,6,9-10,12H,1-2,4-5,7-8H2,(H2,26,27,29,30,31)	QHLSBPRKCLATLW-UHFFFAOYSA-N	280253	US10028961, Compound 412::US10172864, Compound 412::US10946023, Compound 412	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280253	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280253&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817187	378161802							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534058	Fc1cc(F)cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2nc(cs2)C(F)(F)F)c1	InChI=1S/C17H11F7N6S/c18-7-1-8(19)3-9(2-7)25-14-28-12(13-27-11(6-31-13)17(22,23)24)29-15(30-14)26-10-4-16(20,21)5-10/h1-3,6,10H,4-5H2,(H2,25,26,28,29,30)	WGWIGBTYVJCEKX-UHFFFAOYSA-N	280254	US10028961, Compound 413::US10172864, Compound 413::US10946023, Compound 413	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					6.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795599	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280254	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280254&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817195	378161803							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534059	Fc1cc(F)cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2nc(cs2)C(F)(F)F)c1	InChI=1S/C17H11F7N6S/c18-7-1-8(19)3-9(2-7)25-14-28-12(13-27-11(6-31-13)17(22,23)24)29-15(30-14)26-10-4-16(20,21)5-10/h1-3,6,10H,4-5H2,(H2,25,26,28,29,30)	WGWIGBTYVJCEKX-UHFFFAOYSA-N	280254	US10028961, Compound 413::US10172864, Compound 413::US10946023, Compound 413	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280254	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280254&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817195	378161803							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534060	C[C@@H](Nc1cc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)/t11-,12-/m1/s1	MEKMADZCSPFPMP-VXGBXAGGSA-N	280255	US10028961, Compound 414::US10172864, Compound 414::US10946023, Compound 414	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280255	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280255&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817191	378161804							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534064	C[C@@H](Nc1cc(NC(C)(C)C)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C19H24F3N5/c1-11(12-8-9-12)23-15-10-16(27-18(2,3)4)26-17(25-15)13-6-5-7-14(24-13)19(20,21)22/h5-7,10-12H,8-9H2,1-4H3,(H2,23,25,26,27)/t11-/m1/s1	SICOBUZBFFTRIB-LLVKDONJSA-N	280258	US10028961, Compound 417::US10172864, Compound 417::US10946023, Compound 417	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280258	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280258&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817175	378161807							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534066	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC2)cc(NCC2CC2)n1	InChI=1S/C18H20F3N5/c19-18(20,21)14-3-1-2-13(24-14)17-25-15(22-9-11-4-5-11)8-16(26-17)23-10-12-6-7-12/h1-3,8,11-12H,4-7,9-10H2,(H2,22,23,25,26)	QEJQVKBULWEUGT-UHFFFAOYSA-N	280260	US10028961, Compound 419::US10172864, Compound 419::US10946023, Compound 419	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280260	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280260&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817553	378161809							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
534067	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)cc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H23F7N6/c22-19(23)5-1-12(2-6-19)30-16-9-17(31-13-3-7-20(24,25)8-4-13)34-18(33-16)14-10-29-11-15(32-14)21(26,27)28/h9-13H,1-8H2,(H2,30,31,33,34)	UGJNNXSKMGDBMZ-UHFFFAOYSA-N	280262	US10028961, Compound 421::US10172864, Compound 421::US10946023, Compound 421	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550					7.5	25.00 C	US Patent		10.7270/Q2ZW1NXM		aid1795601	US10028961	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	7/24/2018	12/30/2018	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280262	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280262&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817529	378161811							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
548993	CO[C@H]1C2CCC1C[C@H](C2)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r,wU:8.11,wD:2.1,THB:10:8:2:5.4,(1.82,13.81,;2.59,12.47,;1.82,11.14,;.72,10.06,;-.61,10.83,;.2,9.61,;1.81,9.61,;2.56,8.26,;1.46,7.19,;1.47,8.72,;.69,5.85,;-.85,5.85,;1.46,4.52,;3,4.52,;3.96,3.32,;5.43,3.77,;6.56,2.72,;6.22,1.22,;4.75,.77,;3.62,1.81,;2.23,1.15,;.84,1.81,;-.29,.77,;-1.76,1.22,;-2.1,2.72,;-.97,3.77,;.5,3.32,;-3.59,3.12,;-3.99,4.61,;-5.47,5.01,;-6.56,3.92,;-6.16,2.43,;-4.68,2.03,)|	InChI=1S/C26H32N4O3/c1-32-24-17-4-5-18(24)14-20(13-17)26(31)30-16-19-3-2-8-27-25(19)28-22-7-6-21(15-23(22)30)29-9-11-33-12-10-29/h2-3,6-8,15,17-18,20,24H,4-5,9-14,16H2,1H3,(H,27,28)	XDOOGACHFYPBNF-UHFFFAOYSA-N	287780	US10086000, Example 1::6-{[(3r,8r)-3-Methoxybicyclo[3.2.1]oct-8-yl]carbonyl}-8-morpholin-4-yl-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine (Ex. 1)::US10508108, Example 2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1050					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287780	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287780&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383119	378171346							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
548994	CO[C@H]1C2CCC1C[C@@H](C2)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r,wU:8.11,2.1,THB:10:8:2:4.5,(1.82,13.81,;2.59,12.47,;1.82,11.14,;1.81,9.61,;.2,9.61,;-.61,10.83,;.72,10.06,;1.47,8.72,;1.46,7.19,;2.56,8.26,;.69,5.85,;-.85,5.85,;1.46,4.52,;3,4.52,;3.96,3.32,;5.43,3.77,;6.56,2.72,;6.22,1.22,;4.75,.77,;3.62,1.81,;2.23,1.15,;.84,1.81,;-.29,.77,;-1.76,1.22,;-2.1,2.72,;-.97,3.77,;.5,3.32,;-3.59,3.12,;-3.99,4.61,;-5.47,5.01,;-6.56,3.92,;-6.16,2.43,;-4.68,2.03,)|	InChI=1S/C26H32N4O3/c1-32-24-17-4-5-18(24)14-20(13-17)26(31)30-16-19-3-2-8-27-25(19)28-22-7-6-21(15-23(22)30)29-9-11-33-12-10-29/h2-3,6-8,15,17-18,20,24H,4-5,9-14,16H2,1H3,(H,27,28)	XDOOGACHFYPBNF-UHFFFAOYSA-N	287784	US10086000, Example 2::6-{[(3s,8s)-3-methoxybicyclo[3.2.1]oct-8-yl]carbonyl}-8-morpholin-4-yl-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 226					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287784&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383119	378171350							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
548995	CC(C)(C#N)c1ccc2Nc3ncccc3CN(C(=O)C3CCc4ccccc4CC3)c2c1	InChI=1S/C28H28N4O/c1-28(2,18-29)23-13-14-24-25(16-23)32(17-22-8-5-15-30-26(22)31-24)27(33)21-11-9-19-6-3-4-7-20(19)10-12-21/h3-8,13-16,21H,9-12,17H2,1-2H3,(H,30,31)	BTTKTSNRFDGVEO-UHFFFAOYSA-N	287785	US10086000, Example 63::2-Methyl-2-[6-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-ylcarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-8-yl]propanenitrile::US10086000, Example 3::US10508108, Example 63	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287785&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121380037	378171351							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
548996	O=C(C1CC11CCCCC1)N1Cc2cccnc2Nc2ccccc12	InChI=1S/C21H23N3O/c25-20(16-13-21(16)10-4-1-5-11-21)24-14-15-7-6-12-22-19(15)23-17-8-2-3-9-18(17)24/h2-3,6-9,12,16H,1,4-5,10-11,13-14H2,(H,22,23)	QAKJMRUIFCDOPK-UHFFFAOYSA-N	287786	US10086000, Example 4::6-(spiro[2.5]oct-1- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b] [1,5]benzodiazepine::US10508108, Example 4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7676					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287786&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383422	378171352							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
548997	O=C(C1CC11CCCC1)N1Cc2cccnc2Nc2ccccc12	InChI=1S/C20H21N3O/c24-19(15-12-20(15)9-3-4-10-20)23-13-14-6-5-11-21-18(14)22-16-7-1-2-8-17(16)23/h1-2,5-8,11,15H,3-4,9-10,12-13H2,(H,21,22)	LXKWNLLLGXNMBR-UHFFFAOYSA-N	287787	US10086000, Example 5::6-(spiro[2.4]hept-1- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 8483					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287787	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287787&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383424	378171353							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
548998	O=C(N1Cc2cccnc2Nc2ccccc12)C12CC(C1)C2	InChI=1S/C18H17N3O/c22-17(18-8-12(9-18)10-18)21-11-13-4-3-7-19-16(13)20-14-5-1-2-6-15(14)21/h1-7,12H,8-11H2,(H,19,20)	YODPHKSTCKPZRV-UHFFFAOYSA-N	287788	US10086000, Example 6::6-(bicyclo[1.1.1]pent-1- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b] [1,5]benzodiazepine::US10508108, Example 6	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18190					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287788	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287788&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383423	378171354							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
548999	O=C(N1Cc2cccnc2Nc2ccccc12)C12CC(C1)(C2)c1ccccc1	InChI=1S/C24H21N3O/c28-22(24-14-23(15-24,16-24)18-8-2-1-3-9-18)27-13-17-7-6-12-25-21(17)26-19-10-4-5-11-20(19)27/h1-12H,13-16H2,(H,25,26)	URGPPZFJQGVOEU-UHFFFAOYSA-N	287789	US10086000, Example 7::6-[(3- phenylbicyclo[1.1.1]pent- 1-yl)carbonyl]-6,11- dihydro-5H-pyrido[2,3-b] [1,5]benzodiazepine::US10508108, Example 7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1856					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287789&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383421	378171355							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549000	O=C(N1Cc2cccnc2Nc2ccccc12)C12CC(C1)CCC2 |(3.08,.54,;1.54,.54,;.77,-.79,;-.77,-.79,;-1.73,-1.99,;-3.2,-1.54,;-4.33,-2.59,;-3.99,-4.09,;-2.52,-4.54,;-1.39,-3.5,;,-4.16,;1.39,-3.5,;2.52,-4.54,;3.99,-4.09,;4.33,-2.59,;3.2,-1.54,;1.73,-1.99,;.77,1.88,;-.77,1.88,;-1.54,3.21,;-1.87,.78,;-.77,4.54,;.77,4.54,;1.54,3.21,)|	InChI=1S/C20H21N3O/c24-19(20-9-3-5-14(11-20)12-20)23-13-15-6-4-10-21-18(15)22-16-7-1-2-8-17(16)23/h1-2,4,6-8,10,14H,3,5,9,11-13H2,(H,21,22)	BSEJTLMJSAPNDL-UHFFFAOYSA-N	287790	US10086000, Example 8::6-(bicyclo[3.1.1]hept-1- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b] [1,5]benzodiazepine::US10508108, Example 29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1047					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287790	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287790&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383145	378171356							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549001	OC(=O)C1CC2(C1)CC(C2)C(=O)N1Cc2cccnc2Nc2ccccc12	InChI=1S/C21H21N3O3/c25-19(14-8-21(9-14)10-15(11-21)20(26)27)24-12-13-4-3-7-22-18(13)23-16-5-1-2-6-17(16)24/h1-7,14-15H,8-12H2,(H,22,23)(H,26,27)	DQEKQIMBUUOBKX-UHFFFAOYSA-N	287791	US10086000, Example 9::6-(5,11-dihydro-6H- pyrido[2,3-b]  [1,5]benzodiazepin-6- ylcarbonyl)spiro[3.3]heptane- 2-carboxylic acid::US10508108, Example 9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 39390					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287791&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383139	378171357							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549002	O=C(C1CC2(CCC2)C1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1	InChI=1S/C24H28N4O2/c29-23(18-14-24(15-18)6-2-7-24)28-16-17-3-1-8-25-22(17)26-20-5-4-19(13-21(20)28)27-9-11-30-12-10-27/h1,3-5,8,13,18H,2,6-7,9-12,14-16H2,(H,25,26)	GCBARAGFQJUOEA-UHFFFAOYSA-N	287792	US10086000, Example 10::8-morpholin-4-yl-6- (spiro[3.3]hept-2- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 10	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 212					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287792&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383137	378171358							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549003	O=C(C1Cc2ccccc2C1)N1Cc2cccnc2Nc2ccccc12	InChI=1S/C22H19N3O/c26-22(18-12-15-6-1-2-7-16(15)13-18)25-14-17-8-5-11-23-21(17)24-19-9-3-4-10-20(19)25/h1-11,18H,12-14H2,(H,23,24)	DNJVAXHHDDKBTQ-UHFFFAOYSA-N	287793	US10086000, Example 11::6-(2,3-dihydro-1H-inden- 2-ylcarbonyl)-6,11- dihydro-5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 155					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287793&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383136	378171359							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549004	O=C(C1CCc2ccccc12)N1Cc2cccnc2Nc2ccccc12	InChI=1S/C22H19N3O/c26-22(18-12-11-15-6-1-2-8-17(15)18)25-14-16-7-5-13-23-21(16)24-19-9-3-4-10-20(19)25/h1-10,13,18H,11-12,14H2,(H,23,24)	RHRLXOILKKMRIP-UHFFFAOYSA-N	287794	US10086000, Example 12::6-(2,3-dihydro-1H-inden- 1-ylcarbonyl)-6,11- dihydro-5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 12	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1413					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287794&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383138	378171360							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549005	CC(C)(C#N)c1ccc2Nc3ncccc3CN(C(=O)C3Cc4ccccc4C3)c2c1	InChI=1S/C26H24N4O/c1-26(2,16-27)21-9-10-22-23(14-21)30(15-19-8-5-11-28-24(19)29-22)25(31)20-12-17-6-3-4-7-18(17)13-20/h3-11,14,20H,12-13,15H2,1-2H3,(H,28,29)	XVLBKVWNIYZCOZ-UHFFFAOYSA-N	287795	US10086000, Example 13::2-[6-(2,3-dihydro-1H- inden-2-ylcarbonyl)-6,11- dihydro-5H-pyrido[2,3-b]  [1,5]benzodiazepin-8- yl]-2-methylpropanenitrile::US10508108, Example 13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287795	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287795&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121391514	378171361							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549006	O=C(C1CC[C@@H]2CCC[C@H]12)N1Cc2cccnc2Nc2ccccc12 |r|	InChI=1S/C21H23N3O/c25-21(17-11-10-14-5-3-7-16(14)17)24-13-15-6-4-12-22-20(15)23-18-8-1-2-9-19(18)24/h1-2,4,6,8-9,12,14,16-17H,3,5,7,10-11,13H2,(H,22,23)	STLQDTYPGUVMEI-UHFFFAOYSA-N	287796	US10086000, Example 14::6-[(3aS,6aS)- octahydropentalen-1- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 630					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287796&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121391512	378171362							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549007	OC1CC[C@H]2C[C@@H]1CC2C(=O)N1Cc2cccnc2Nc2ccccc12 |r|	InChI=1S/C21H23N3O2/c25-19-8-7-13-10-15(19)11-16(13)21(26)24-12-14-4-3-9-22-20(14)23-17-5-1-2-6-18(17)24/h1-6,9,13,15-16,19,25H,7-8,10-12H2,(H,22,23)	PWKMNDSPDWBHBT-UHFFFAOYSA-N	287797	US10086000, Example 15::(1R,5S)-6-(5,11-dihydro- 6H-pyrido[2,3-b]  [1,5]benzodiazepin-6- ylcarbonyl)bicyclo[3.2.1] octan-2-ol::US10508108, Example 15	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 26370					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287797&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383181	378171363							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549008	O=C([C@H]1CC2CCC1C2)N1Cc2cccnc2Nc2ccccc12 |r|	InChI=1S/C20H21N3O/c24-20(16-11-13-7-8-14(16)10-13)23-12-15-4-3-9-21-19(15)22-17-5-1-2-6-18(17)23/h1-6,9,13-14,16H,7-8,10-12H2,(H,21,22)	FQCKHMVMLRRHCN-UHFFFAOYSA-N	287798	US10086000, Example 16::6-[(2S)-bicyclo[2.2.1]hept- 2-ylcarbonyl]-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 16	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 8854					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287798&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383177	378171364							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549009	O=C(N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1)C12CCC(CC1)C2	InChI=1S/C24H28N4O2/c29-23(24-7-5-17(15-24)6-8-24)28-16-18-2-1-9-25-22(18)26-20-4-3-19(14-21(20)28)27-10-12-30-13-11-27/h1-4,9,14,17H,5-8,10-13,15-16H2,(H,25,26)	XHSVAESXPWMSLV-UHFFFAOYSA-N	287799	US10086000, Example 17::6-(bicyclo[2.2.1]hept-1- ylcarbonyl)-8-morpholin- 4-yl-6,11-dihydro-5H- pyrido[2,3-b]  [1,5]benzodiazepine::US10086000, Example 33::US10508108, Example 33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1753					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287799&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383178	378171365							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549010	FC1(F)C2CC(CC12)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1	InChI=1S/C23H24F2N4O2/c24-23(25)17-10-15(11-18(17)23)22(30)29-13-14-2-1-5-26-21(14)27-19-4-3-16(12-20(19)29)28-6-8-31-9-7-28/h1-5,12,15,17-18H,6-11,13H2,(H,26,27)	HOPMEMZGFNKSEX-UHFFFAOYSA-N	287800	US10086000, Example 18::6-[(6,6- difluorobicyclo[3.1.0]hex- 3-yl)carbonyl]-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 18	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 218					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287800	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287800&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383182	378171366							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549011	FC1(F)[C@H]2C[C@H](C[C@@H]12)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C23H24F2N4O2/c24-23(25)17-10-15(11-18(17)23)22(30)29-13-14-2-1-5-26-21(14)27-19-4-3-16(12-20(19)29)28-6-8-31-9-7-28/h1-5,12,15,17-18H,6-11,13H2,(H,26,27)	HOPMEMZGFNKSEX-UHFFFAOYSA-N	287801	US10086000, Example 19::6-{[(1R,3r,5S)-6,6- difluorobicyclo[3.1.0]hex- 3-yl]carbonyl}-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 19	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 148					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287801&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132230290	378171367							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549012	O=C(C1CC[C@H]2CCC[C@@H]12)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C25H30N4O2/c30-25(21-8-6-17-3-1-5-20(17)21)29-16-18-4-2-10-26-24(18)27-22-9-7-19(15-23(22)29)28-11-13-31-14-12-28/h2,4,7,9-10,15,17,20-21H,1,3,5-6,8,11-14,16H2,(H,26,27)	GFNNTYKPDNITHZ-UHFFFAOYSA-N	287802	US10086000, Example 20::8-morpholin-4-yl-6- [(3aR,6aR)- octahydropentalen-1- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b] [1,5]benzodiazepine::US10508108, Example 20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 99.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287802&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383180	378171368							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549013	O=C(C1CCc2ccccc2C1)N1Cc2cccnc2Nc2ccccc12	InChI=1S/C23H21N3O/c27-23(18-12-11-16-6-1-2-7-17(16)14-18)26-15-19-8-5-13-24-22(19)25-20-9-3-4-10-21(20)26/h1-10,13,18H,11-12,14-15H2,(H,24,25)	IANZHQFMVUYITC-UHFFFAOYSA-N	287803	US10086000, Example 21::6-(1,2,3,4- tetrahydronaphthalen-2- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 440					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287803&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383205	378171369							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549014	COC(=O)C12CCC(CC1)(CC2)C(=O)N1Cc2cccnc2Nc2ccccc12	InChI=1S/C23H25N3O3/c1-29-21(28)23-11-8-22(9-12-23,10-13-23)20(27)26-15-16-5-4-14-24-19(16)25-17-6-2-3-7-18(17)26/h2-7,14H,8-13,15H2,1H3,(H,24,25)	SMFBJFMCKDSNDJ-UHFFFAOYSA-N	287804	US10086000, Example 22::methyl 4-(5,11-dihydro- 6H-pyrido[2,3-b]  [1,5]benzodiazepin-6- ylcarbonyl)bicyclo[2.2.2] octane-1-carboxylate::US10508108, Example 22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2169					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287804	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287804&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121380024	378171370							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549015	CC1(CCc2ccccc2C1)C(=O)N1Cc2cccnc2Nc2ccccc12	InChI=1S/C24H23N3O/c1-24(13-12-17-7-2-3-8-18(17)15-24)23(28)27-16-19-9-6-14-25-22(19)26-20-10-4-5-11-21(20)27/h2-11,14H,12-13,15-16H2,1H3,(H,25,26)	FWCCAQQYZOTNTF-UHFFFAOYSA-N	287805	US10086000, Example 23::6-[(2-methyl-1,2,3,4- tetrahydronaphthalen-2- yl)carbonyl]-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 23	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 611					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287805&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383200	378171371							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549016	O=C(N1Cc2cccnc2Nc2ccccc12)C12CCC(CC1)CC2	InChI=1S/C21H23N3O/c25-20(21-10-7-15(8-11-21)9-12-21)24-14-16-4-3-13-22-19(16)23-17-5-1-2-6-18(17)24/h1-6,13,15H,7-12,14H2,(H,22,23)	UMQUREWZZGMPOG-UHFFFAOYSA-N	287806	US10086000, Example 24::6-(bicyclo[2.2.2]oct-1- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 24	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1061					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287806&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383199	378171372							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549017	O=C(N1Cc2cccnc2Nc2ccccc12)[C@]12C[C@H]3C[C@H](C[C@H](C3)C1)C2 |r,TLB:20:21:18.19.24:25|	InChI=1S/C23H25N3O/c27-22(23-11-15-8-16(12-23)10-17(9-15)13-23)26-14-18-4-3-7-24-21(18)25-19-5-1-2-6-20(19)26/h1-7,15-17H,8-14H2,(H,24,25)	ROAFOJSTKOETLT-UHFFFAOYSA-N	287807	US10086000, Example 25::6-[(3s,5s,7s)- tricyclo[3.3.1.1~3,7~]dec- 1-ylcarbonyl]-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 25	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 864					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287807&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132230282	378171373							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549018	O=C(N1Cc2cccnc2Nc2ccccc12)C12CCC(CC1)(C=C2)C#N |c:27,(-2.92,.96,;-1.44,.56,;-1.04,-.93,;.46,-1.27,;1.13,-2.66,;2.67,-2.54,;3.53,-3.81,;2.87,-5.2,;1.33,-5.32,;.46,-4.04,;-1.04,-4.39,;-2.24,-3.43,;-3.58,-4.2,;-4.91,-3.43,;-4.91,-1.89,;-3.58,-1.12,;-2.24,-1.89,;-.35,1.65,;.05,3.14,;2.23,5.32,;1.83,3.83,;2.23,2.34,;1.14,1.25,;.34,4.23,;-.75,3.14,;3.37,3.83,;4.91,3.83,)|	InChI=1S/C22H20N4O/c23-15-21-7-10-22(11-8-21,12-9-21)20(27)26-14-16-4-3-13-24-19(16)25-17-5-1-2-6-18(17)26/h1-7,10,13H,8-9,11-12,14H2,(H,24,25)	VCILLUCAWLRYSC-UHFFFAOYSA-N	287808	US10086000, Example 26::4-(5,11-dihydro-6H- pyrido[2,3-b]  [1,5]benzodiazepin-6- ylcarbonyl)bicyclo[2.2.2] oct-2-ene-1-carbonitrile::US10508108, Example 26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 860					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287808&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132230295	378171374							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549019	CC(=O)C12CCC(CC1)(C=C2)C(=O)N1Cc2cccnc2Nc2ccccc12 |c:10,(4.72,3.61,;3.24,4.01,;2.84,5.5,;2.15,2.92,;.66,3.32,;-.43,2.23,;-.03,.74,;.37,2.23,;1.75,4.41,;1.46,.35,;2.55,1.43,;-1.12,-.35,;-2.61,.05,;-.72,-1.83,;.82,-1.83,;1.91,-2.92,;3.39,-2.52,;4.48,-3.61,;4.09,-5.1,;2.6,-5.5,;1.51,-4.41,;-.72,-4.91,;-2.06,-4.14,;-3.39,-4.91,;-4.72,-4.14,;-4.72,-2.6,;-3.39,-1.83,;-2.06,-2.6,)|	InChI=1S/C23H23N3O2/c1-16(27)22-8-11-23(12-9-22,13-10-22)21(28)26-15-17-5-4-14-24-20(17)25-18-6-2-3-7-19(18)26/h2-8,11,14H,9-10,12-13,15H2,1H3,(H,24,25)	KZMUGPYUDXHKHK-UHFFFAOYSA-N	287809	US10086000, Example 27::1-[4-(5,11-dihydro-6H- pyrido[2,3-b]  [1,5]benzodiazepin-6- ylcarbonyl)bicyclo[2.2.2] oct-2-en-1-yl]ethanone::US10508108, Example 27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1440					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287809&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132230298	378171375							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549020	CCCCC[C@@]12CC[C@@](CC1)(CC2)C(=O)N1Cc2cccnc2Nc2ccccc12 |r|	InChI=1S/C26H33N3O/c1-2-3-6-11-25-12-15-26(16-13-25,17-14-25)24(30)29-19-20-8-7-18-27-23(20)28-21-9-4-5-10-22(21)29/h4-5,7-10,18H,2-3,6,11-17,19H2,1H3,(H,27,28)	WHYICUUFTRPDIB-UHFFFAOYSA-N	287810	US10086000, Example 28::6-[(4- pentylbicyclo[2.2.2]oct-1- yl)carbonyl]-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 28	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 563					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287810&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132230270	378171376							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549021	O=C(N1Cc2cccnc2Nc2ccccc12)C12CC(C1)CCC2 |(3.08,.54,;1.54,.54,;.77,-.79,;-.77,-.79,;-1.73,-1.99,;-3.2,-1.54,;-4.33,-2.59,;-3.99,-4.09,;-2.52,-4.54,;-1.39,-3.5,;,-4.16,;1.39,-3.5,;2.52,-4.54,;3.99,-4.09,;4.33,-2.59,;3.2,-1.54,;1.73,-1.99,;.77,1.88,;-.77,1.88,;-1.54,3.21,;-1.85,.6,;-.77,4.54,;.77,4.54,;1.54,3.21,)|	InChI=1S/C20H21N3O/c24-19(20-9-3-5-14(11-20)12-20)23-13-15-6-4-10-21-18(15)22-16-7-1-2-8-17(16)23/h1-2,4,6-8,10,14H,3,5,9,11-13H2,(H,21,22)	BSEJTLMJSAPNDL-UHFFFAOYSA-N	287811	US10086000, Example 29::6-(bicyclo[3.1.1]hept-1- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b] [1,5]benzodiazepine	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1047					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287811&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383145	378171377							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549022	FC1(F)C2CCC1CC(C2)C(=O)N1Cc2cccnc2Nc2ccccc12	InChI=1S/C21H21F2N3O/c22-21(23)15-7-8-16(21)11-14(10-15)20(27)26-12-13-4-3-9-24-19(13)25-17-5-1-2-6-18(17)26/h1-6,9,14-16H,7-8,10-12H2,(H,24,25)	VZYNKLSHDTXNNA-UHFFFAOYSA-N	287812	US10086000, Example 30::6-[(8,8- difluorobicyclo[3.2.1]oct- 3-yl)carbonyl]-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10086000, Example 67::US10508108, Example 67	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1767					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287812&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132230247	378171378							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549023	FC12CC3CC(C1)CC(C3)(C2)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |TLB:4:5:9.3.2:10,THB:6:5:9:2.1.10|	InChI=1S/C27H31FN4O2/c28-27-14-18-10-19(15-27)13-26(12-18,17-27)25(33)32-16-20-2-1-5-29-24(20)30-22-4-3-21(11-23(22)32)31-6-8-34-9-7-31/h1-5,11,18-19H,6-10,12-17H2,(H,29,30)	LMBKDLGEAJAVDN-UHFFFAOYSA-N	287813	US10086000, Example 31::6-[(3- fluorotricyclo[3.3.1.1~3,7~] dec-1-yl)carbonyl]-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 31	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 225					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287813&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383143	378171379							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549024	FC12CC3CC(F)(C1)CC(C3)(C2)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |THB:2:3:8:7.11.1,10:3:7:8.11.9|	InChI=1S/C27H30F2N4O2/c28-26-12-18-11-25(15-26,16-27(29,13-18)17-26)24(34)33-14-19-2-1-5-30-23(19)31-21-4-3-20(10-22(21)33)32-6-8-35-9-7-32/h1-5,10,18H,6-9,11-17H2,(H,30,31)	RGFSGIZGUMBUDS-UHFFFAOYSA-N	287814	US10086000, Example 32::6-[(3,5- difluorotricyclo[3.3.1.1~3,7~] dec-1-yl)carbonyl]-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 32	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 97.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287814&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383426	378171380							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549025	O=C(N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1)C12CCC(CC1)C2	InChI=1S/C24H28N4O2/c29-23(24-7-5-17(15-24)6-8-24)28-16-18-2-1-9-25-22(18)26-20-4-3-19(14-21(20)28)27-10-12-30-13-11-27/h1-4,9,14,17H,5-8,10-13,15-16H2,(H,25,26)	XHSVAESXPWMSLV-UHFFFAOYSA-N	287799	US10086000, Example 17::6-(bicyclo[2.2.1]hept-1- ylcarbonyl)-8-morpholin- 4-yl-6,11-dihydro-5H- pyrido[2,3-b]  [1,5]benzodiazepine::US10086000, Example 33::US10508108, Example 33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1753					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287799&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383178	378171365							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549026	O=C([C@H]1CC[C@@H]2OCC[C@@H]2C1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C25H30N4O3/c30-25(18-3-6-23-17(14-18)7-11-32-23)29-16-19-2-1-8-26-24(19)27-21-5-4-20(15-22(21)29)28-9-12-31-13-10-28/h1-2,4-5,8,15,17-18,23H,3,6-7,9-14,16H2,(H,26,27)	WAPAMYWWIBYLFJ-UHFFFAOYSA-N	287816	US10086000, Example 34::8-morpholin-4-yl-6- [(3aS,5R,7aS)-octahydro- 1-benzofuran-5- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 34	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1522					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287816&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383425	378171381							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549027	O=C([C@@H]1CC[C@H]2OCC[C@H]2C1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C25H30N4O3/c30-25(18-3-6-23-17(14-18)7-11-32-23)29-16-19-2-1-8-26-24(19)27-21-5-4-20(15-22(21)29)28-9-12-31-13-10-28/h1-2,4-5,8,15,17-18,23H,3,6-7,9-14,16H2,(H,26,27)	WAPAMYWWIBYLFJ-UHFFFAOYSA-N	287817	US10086000, Example 35::8-morpholin-4-yl-6- [(3aR,5S,7aR)-octahydro- 1-benzofuran-5- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 9482					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287817&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383428	378171382							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549028	O=C([C@@H]1CC[C@@H]2OCC[C@@H]2C1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C25H30N4O3/c30-25(18-3-6-23-17(14-18)7-11-32-23)29-16-19-2-1-8-26-24(19)27-21-5-4-20(15-22(21)29)28-9-12-31-13-10-28/h1-2,4-5,8,15,17-18,23H,3,6-7,9-14,16H2,(H,26,27)	WAPAMYWWIBYLFJ-UHFFFAOYSA-N	287818	US10086000, Example 36::8-morpholin-4-yl-6- [(3aS,5R,7aS)-octahydro- 1-benzofuran-5- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2314					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287818&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383427	378171383							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549029	O=C([C@H]1CC[C@H]2OCC[C@H]2C1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C25H30N4O3/c30-25(18-3-6-23-17(14-18)7-11-32-23)29-16-19-2-1-8-26-24(19)27-21-5-4-20(15-22(21)29)28-9-12-31-13-10-28/h1-2,4-5,8,15,17-18,23H,3,6-7,9-14,16H2,(H,26,27)	WAPAMYWWIBYLFJ-UHFFFAOYSA-N	287819	US10086000, Example 37::8-morpholin-4-yl-6- [(3aR,5S,7aR)-octahydro- 1-benzofuran-5- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 37	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2365					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287819&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383186	378171384							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549030	O=C([C@H]1CC[C@@H]2OCCC[C@@H]2C1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C26H32N4O3/c31-26(19-5-8-24-18(15-19)4-2-12-33-24)30-17-20-3-1-9-27-25(20)28-22-7-6-21(16-23(22)30)29-10-13-32-14-11-29/h1,3,6-7,9,16,18-19,24H,2,4-5,8,10-15,17H2,(H,27,28)	UTMOKHXHNIIZLQ-UHFFFAOYSA-N	287820	US10086000, Example 38::8-morpholin-4-yl-6- [(4aR,6S,8aS)-octahydro- 2H-chromen-6- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10086000, Example 45::US10508108, Example 45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 393					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287820&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383148	378171385							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549031	O=C([C@@H]1CC[C@@H]2OCCC[C@@H]2C1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C26H32N4O3/c31-26(19-5-8-24-18(15-19)4-2-12-33-24)30-17-20-3-1-9-27-25(20)28-22-7-6-21(16-23(22)30)29-10-13-32-14-11-29/h1,3,6-7,9,16,18-19,24H,2,4-5,8,10-15,17H2,(H,27,28)	UTMOKHXHNIIZLQ-UHFFFAOYSA-N	287821	US10086000, Example 39::US10086000, Example 51::8-morpholin-4-yl-6- [(4aR,6R,8aS)-octahydro- 2H-chromen-6- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 51	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 624					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287821&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383151	378171386							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549032	O=C(C1COc2ccccc2O1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1	InChI=1S/C25H24N4O4/c30-25(23-16-32-21-5-1-2-6-22(21)33-23)29-15-17-4-3-9-26-24(17)27-19-8-7-18(14-20(19)29)28-10-12-31-13-11-28/h1-9,14,23H,10-13,15-16H2,(H,26,27)	YBRMOQHMZVGLOF-UHFFFAOYSA-N	287822	US10086000, Example 40::6-(2,3-dihydro-1,4- benzodioxin-2-ylcarbonyl)- 8-morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 171					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287822	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287822&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383187	378171387							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549033	O=C(C1CCc2ccccc2O1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1	InChI=1S/C26H26N4O3/c31-26(24-10-7-18-4-1-2-6-23(18)33-24)30-17-19-5-3-11-27-25(19)28-21-9-8-20(16-22(21)30)29-12-14-32-15-13-29/h1-6,8-9,11,16,24H,7,10,12-15,17H2,(H,27,28)	YKXYFKWKXJMBAT-UHFFFAOYSA-N	287823	US10086000, Example 41::6-(3,4-dihydro-2H- chromen-2-ylcarbonyl)-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 95.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287823	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287823&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383185	378171388							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549034	O=C([C@H]1COc2ccccc2O1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C25H24N4O4/c30-25(23-16-32-21-5-1-2-6-22(21)33-23)29-15-17-4-3-9-26-24(17)27-19-8-7-18(14-20(19)29)28-10-12-31-13-11-28/h1-9,14,23H,10-13,15-16H2,(H,26,27)	YBRMOQHMZVGLOF-UHFFFAOYSA-N	287824	US10086000, Example 42::6-[(2R)-2,3-dihydro-1,4- benzodioxin-2-ylcarbonyl]- 8-morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 42	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 87.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287824	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287824&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132230306	378171389							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549035	O=C([C@@H]1COc2ccccc2O1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C25H24N4O4/c30-25(23-16-32-21-5-1-2-6-22(21)33-23)29-15-17-4-3-9-26-24(17)27-19-8-7-18(14-20(19)29)28-10-12-31-13-11-28/h1-9,14,23H,10-13,15-16H2,(H,26,27)	YBRMOQHMZVGLOF-UHFFFAOYSA-N	287825	US10086000, Example 43::6-[(2S)-2,3-dihydro-1,4- benzodioxin-2-ylcarbonyl]- 8-morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 43	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 626					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287825	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287825&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383147	378171390							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549036	CCCOc1ccc2CC(COc2c1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1	InChI=1S/C29H32N4O4/c1-2-12-36-24-7-5-20-15-22(19-37-27(20)17-24)29(34)33-18-21-4-3-9-30-28(21)31-25-8-6-23(16-26(25)33)32-10-13-35-14-11-32/h3-9,16-17,22H,2,10-15,18-19H2,1H3,(H,30,31)	NBYJMCFNKXBJIM-UHFFFAOYSA-N	287826	US10086000, Example 44::8-morpholin-4-yl-6-[(7- propoxy-3,4-dihydro-2H- chromen-3-yl)carbonyl]- 6,11-dihydro-5H- pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 626					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287826&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383146	378171391							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549037	O=C([C@H]1CC[C@@H]2OCCC[C@@H]2C1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C26H32N4O3/c31-26(19-5-8-24-18(15-19)4-2-12-33-24)30-17-20-3-1-9-27-25(20)28-22-7-6-21(16-23(22)30)29-10-13-32-14-11-29/h1,3,6-7,9,16,18-19,24H,2,4-5,8,10-15,17H2,(H,27,28)	UTMOKHXHNIIZLQ-UHFFFAOYSA-N	287820	US10086000, Example 38::8-morpholin-4-yl-6- [(4aR,6S,8aS)-octahydro- 2H-chromen-6- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10086000, Example 45::US10508108, Example 45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 123					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287820&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383148	378171385							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549038	O=C([C@@H]1CC[C@H]2OCCC[C@H]2C1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C26H32N4O3/c31-26(19-5-8-24-18(15-19)4-2-12-33-24)30-17-20-3-1-9-27-25(20)28-22-7-6-21(16-23(22)30)29-10-13-32-14-11-29/h1,3,6-7,9,16,18-19,24H,2,4-5,8,10-15,17H2,(H,27,28)	UTMOKHXHNIIZLQ-UHFFFAOYSA-N	287828	US10086000, Example 46::8-morpholin-4-yl-6- [(4aS,6R,8aR)-octahydro- 2H-chromen-6- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 46	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1581					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287828&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383149	378171392							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549039	O=C([C@H]1CC[C@@H]2OCCC[C@H]2C1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C26H32N4O3/c31-26(19-5-8-24-18(15-19)4-2-12-33-24)30-17-20-3-1-9-27-25(20)28-22-7-6-21(16-23(22)30)29-10-13-32-14-11-29/h1,3,6-7,9,16,18-19,24H,2,4-5,8,10-15,17H2,(H,27,28)	UTMOKHXHNIIZLQ-UHFFFAOYSA-N	287829	US10086000, Example 47::8-morpholin-4-yl-6- [(4aS,6S,8aS)-octahydro- 2H-chromen-6- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b] [1,5]benzodiazepine::US10508108, Example 47	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11010					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287829&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383154	378171393							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549040	O=C([C@@H]1CC[C@H]2OCCC[C@@H]2C1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C26H32N4O3/c31-26(19-5-8-24-18(15-19)4-2-12-33-24)30-17-20-3-1-9-27-25(20)28-22-7-6-21(16-23(22)30)29-10-13-32-14-11-29/h1,3,6-7,9,16,18-19,24H,2,4-5,8,10-15,17H2,(H,27,28)	UTMOKHXHNIIZLQ-UHFFFAOYSA-N	287830	US10086000, Example 48::8-morpholin-4-yl-6- [(4aR,6R,8aR)-octahydro- 2H-chromen-6- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 48	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1867					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287830	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287830&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383150	378171394							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549041	O=C([C@@H]1CC[C@@H]2OCCC[C@H]2C1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C26H32N4O3/c31-26(19-5-8-24-18(15-19)4-2-12-33-24)30-17-20-3-1-9-27-25(20)28-22-7-6-21(16-23(22)30)29-10-13-32-14-11-29/h1,3,6-7,9,16,18-19,24H,2,4-5,8,10-15,17H2,(H,27,28)	UTMOKHXHNIIZLQ-UHFFFAOYSA-N	287831	US10086000, Example 49::8-morpholin-4-yl-6- [(4aS,6R,8aS)-octahydro- 2H-chromen-6- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 49	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2479					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287831	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287831&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383153	378171395							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549042	O=C([C@H]1CC[C@H]2OCCC[C@@H]2C1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C26H32N4O3/c31-26(19-5-8-24-18(15-19)4-2-12-33-24)30-17-20-3-1-9-27-25(20)28-22-7-6-21(16-23(22)30)29-10-13-32-14-11-29/h1,3,6-7,9,16,18-19,24H,2,4-5,8,10-15,17H2,(H,27,28)	UTMOKHXHNIIZLQ-UHFFFAOYSA-N	287832	US10086000, Example 50::8-morpholin-4-yl-6- [(4aR,6S,8aR)-octahydro- 2H-chromen-6- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 50	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2477					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287832&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383152	378171396							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549043	O=C([C@@H]1CC[C@@H]2OCCC[C@@H]2C1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C26H32N4O3/c31-26(19-5-8-24-18(15-19)4-2-12-33-24)30-17-20-3-1-9-27-25(20)28-22-7-6-21(16-23(22)30)29-10-13-32-14-11-29/h1,3,6-7,9,16,18-19,24H,2,4-5,8,10-15,17H2,(H,27,28)	UTMOKHXHNIIZLQ-UHFFFAOYSA-N	287821	US10086000, Example 39::US10086000, Example 51::8-morpholin-4-yl-6- [(4aR,6R,8aS)-octahydro- 2H-chromen-6- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 51	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 667					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287821&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383151	378171386							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549044	O=C([C@H]1CC[C@H]2OCCC[C@H]2C1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C26H32N4O3/c31-26(19-5-8-24-18(15-19)4-2-12-33-24)30-17-20-3-1-9-27-25(20)28-22-7-6-21(16-23(22)30)29-10-13-32-14-11-29/h1,3,6-7,9,16,18-19,24H,2,4-5,8,10-15,17H2,(H,27,28)	UTMOKHXHNIIZLQ-UHFFFAOYSA-N	287834	US10086000, Example 52::8-morpholin-4-yl-6- [(4aS,6S,8aR)-octahydro- 2H-chromen-6- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 52	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 257					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287834&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383384	378171397							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549045	C[C@@H]1C[C@@H]2C[C@H](CC[C@@H]2O1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C26H32N4O3/c1-17-13-20-14-18(4-7-24(20)33-17)26(31)30-16-19-3-2-8-27-25(19)28-22-6-5-21(15-23(22)30)29-9-11-32-12-10-29/h2-3,5-6,8,15,17-18,20,24H,4,7,9-14,16H2,1H3,(H,27,28)	FGDXCCDUKHSLJT-UHFFFAOYSA-N	287836	US10086000, Example 53::6-{[(2R,3aS,5R,7aS)-2- methyloctahydro-1- benzofuran-5-yl]carbonyl}- 8-morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 53	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1692					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287836	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287836&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383383	378171399							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549046	C[C@H]1C[C@H]2C[C@@H](CC[C@H]2O1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C26H32N4O3/c1-17-13-20-14-18(4-7-24(20)33-17)26(31)30-16-19-3-2-8-27-25(19)28-22-6-5-21(15-23(22)30)29-9-11-32-12-10-29/h2-3,5-6,8,15,17-18,20,24H,4,7,9-14,16H2,1H3,(H,27,28)	FGDXCCDUKHSLJT-UHFFFAOYSA-N	287837	US10086000, Example 54::6-{[(2S,3aR,5S,7aR)-2- methyloctahydro-1- benzofuran-5-yl]carbonyl}- 8-morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 54	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 6137					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287837&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383385	378171400							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549047	C[C@@H]1C[C@@H]2C[C@@H](CC[C@@H]2O1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C26H32N4O3/c1-17-13-20-14-18(4-7-24(20)33-17)26(31)30-16-19-3-2-8-27-25(19)28-22-6-5-21(15-23(22)30)29-9-11-32-12-10-29/h2-3,5-6,8,15,17-18,20,24H,4,7,9-14,16H2,1H3,(H,27,28)	FGDXCCDUKHSLJT-UHFFFAOYSA-N	287838	US10086000, Example 55::6-{[(2R,3aS,5R,7aS)-2- methyloctahydro-1- benzofuran-5-yl]carbonyl}- 8-morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 55	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1073					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287838&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383386	378171401							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549048	C[C@H]1C[C@H]2C[C@H](CC[C@H]2O1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C26H32N4O3/c1-17-13-20-14-18(4-7-24(20)33-17)26(31)30-16-19-3-2-8-27-25(19)28-22-6-5-21(15-23(22)30)29-9-11-32-12-10-29/h2-3,5-6,8,15,17-18,20,24H,4,7,9-14,16H2,1H3,(H,27,28)	FGDXCCDUKHSLJT-UHFFFAOYSA-N	287839	US10086000, Example 56::6-{[(2S,3aR,5S,7aR)-2- methyloctahydro-1- benzofuran-5-yl]carbonyl}- 8-morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 56	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 351					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287839&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383431	378171402							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549049	CO[C@H]1C2CC3CC1C[C@](C3)(C2)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r,wU:9.14,wD:2.1,TLB:1:2:5.10.6:8,2:3:10:6.8.7,THB:4:3:5.10.6:8,4:5:11.3.2:8,2:7:11.3.4:10,(6.87,3.45,;6.1,2.12,;4.56,2.12,;3.47,3.21,;2.7,4.54,;1.16,4.54,;1.56,3.06,;3.33,1.88,;2.25,.79,;1.16,1.88,;.39,3.21,;2.7,1.88,;.39,.54,;-1.15,.54,;1.16,-.79,;2.7,-.79,;3.66,-1.99,;5.13,-1.54,;6.26,-2.59,;5.92,-4.09,;4.44,-4.54,;3.31,-3.5,;1.93,-4.16,;.54,-3.5,;-.59,-4.54,;-2.06,-4.09,;-2.4,-2.59,;-1.27,-1.54,;.2,-1.99,;-3.89,-2.19,;-4.29,-.7,;-5.78,-.3,;-6.87,-1.39,;-6.47,-2.88,;-4.98,-3.28,)|	InChI=1S/C28H34N4O3/c1-34-25-20-11-18-12-21(25)16-28(14-18,15-20)27(33)32-17-19-3-2-6-29-26(19)30-23-5-4-22(13-24(23)32)31-7-9-35-10-8-31/h2-6,13,18,20-21,25H,7-12,14-17H2,1H3,(H,29,30)	KIYGAKICNZWUBX-UHFFFAOYSA-N	287840	US10086000, Example 57::6-{[(1r,4s)-4- methoxytricyclo[3.3.1.1~3,7~] dec-1-yl]carbonyl}-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 57	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 424					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287840&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132230291	378171403							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549050	CO[C@H]1C2CC3CC1C[C@@](C3)(C2)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r,wD:9.14,2.1,TLB:1:2:5.10.6:8,2:3:10:6.8.7,THB:4:3:5.10.6:8,4:5:11.3.2:8,2:7:11.3.4:10,(6.87,3.45,;6.1,2.12,;4.56,2.12,;3.47,3.21,;2.7,4.54,;1.16,4.54,;1.56,3.06,;3.33,1.88,;2.25,.79,;1.16,1.88,;.39,3.21,;2.7,1.88,;.39,.54,;-1.15,.54,;1.16,-.79,;2.7,-.79,;3.66,-1.99,;5.13,-1.54,;6.26,-2.59,;5.92,-4.09,;4.44,-4.54,;3.31,-3.5,;1.93,-4.16,;.54,-3.5,;-.59,-4.54,;-2.06,-4.09,;-2.4,-2.59,;-1.27,-1.54,;.2,-1.99,;-3.89,-2.19,;-4.29,-.7,;-5.78,-.3,;-6.87,-1.39,;-6.47,-2.88,;-4.98,-3.28,)|	InChI=1S/C28H34N4O3/c1-34-25-20-11-18-12-21(25)16-28(14-18,15-20)27(33)32-17-19-3-2-6-29-26(19)30-23-5-4-22(13-24(23)32)31-7-9-35-10-8-31/h2-6,13,18,20-21,25H,7-12,14-17H2,1H3,(H,29,30)	KIYGAKICNZWUBX-UHFFFAOYSA-N	287841	US10086000, Example 58::6-{[(1s,4r)-4- methoxytricyclo[3.3.1.1~3,7~] dec-1-yl]carbonyl}-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 9931					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287841&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132230291	378171404							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549051	COC1CC2CCC1CC2C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1	InChI=1S/C26H32N4O3/c1-32-24-14-17-4-5-18(24)13-21(17)26(31)30-16-19-3-2-8-27-25(19)28-22-7-6-20(15-23(22)30)29-9-11-33-12-10-29/h2-3,6-8,15,17-18,21,24H,4-5,9-14,16H2,1H3,(H,27,28)	PJIUDMDJHSCGGP-UHFFFAOYSA-N	287842	US10086000, Example 59::US10086000, Example 61::6-[(5- methoxybicyclo[2.2.2]oct- 2-yl)carbonyl]-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10086000, Example 60::US10508108, Example 61	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14190					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287842&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383188	378171405							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549052	COC1CC2CCC1CC2C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1	InChI=1S/C26H32N4O3/c1-32-24-14-17-4-5-18(24)13-21(17)26(31)30-16-19-3-2-8-27-25(19)28-22-7-6-20(15-23(22)30)29-9-11-33-12-10-29/h2-3,6-8,15,17-18,21,24H,4-5,9-14,16H2,1H3,(H,27,28)	PJIUDMDJHSCGGP-UHFFFAOYSA-N	287842	US10086000, Example 59::US10086000, Example 61::6-[(5- methoxybicyclo[2.2.2]oct- 2-yl)carbonyl]-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10086000, Example 60::US10508108, Example 61	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1461					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287842&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383188	378171405							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549053	COC1CC2CCC1CC2C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1	InChI=1S/C26H32N4O3/c1-32-24-14-17-4-5-18(24)13-21(17)26(31)30-16-19-3-2-8-27-25(19)28-22-7-6-20(15-23(22)30)29-9-11-33-12-10-29/h2-3,6-8,15,17-18,21,24H,4-5,9-14,16H2,1H3,(H,27,28)	PJIUDMDJHSCGGP-UHFFFAOYSA-N	287842	US10086000, Example 59::US10086000, Example 61::6-[(5- methoxybicyclo[2.2.2]oct- 2-yl)carbonyl]-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10086000, Example 60::US10508108, Example 61	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4064					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287842&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383188	378171405							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549054	O=C(C1CCc2ccccc2CC1)N1Cc2cccnc2Nc2ccccc12	InChI=1S/C24H23N3O/c28-24(19-13-11-17-6-1-2-7-18(17)12-14-19)27-16-20-8-5-15-25-23(20)26-21-9-3-4-10-22(21)27/h1-10,15,19H,11-14,16H2,(H,25,26)	VLFIKYSHKDFKHR-UHFFFAOYSA-N	287845	US10086000, Example 62::6-(6,7,8,9-tetrahydro-5H- benzo[7]annulen-7- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 62	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 9.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287845&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383190	378171406							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549055	CC(C)(C#N)c1ccc2Nc3ncccc3CN(C(=O)C3CCc4ccccc4CC3)c2c1	InChI=1S/C28H28N4O/c1-28(2,18-29)23-13-14-24-25(16-23)32(17-22-8-5-15-30-26(22)31-24)27(33)21-11-9-19-6-3-4-7-20(19)10-12-21/h3-8,13-16,21H,9-12,17H2,1-2H3,(H,30,31)	BTTKTSNRFDGVEO-UHFFFAOYSA-N	287785	US10086000, Example 63::2-Methyl-2-[6-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-ylcarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-8-yl]propanenitrile::US10086000, Example 3::US10508108, Example 63	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287785&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121380037	378171351							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549056	Brc1ccc2Nc3ncccc3CN(C(=O)C3CCc4ccccc4CC3)c2c1	InChI=1S/C24H22BrN3O/c25-20-11-12-21-22(14-20)28(15-19-6-3-13-26-23(19)27-21)24(29)18-9-7-16-4-1-2-5-17(16)8-10-18/h1-6,11-14,18H,7-10,15H2,(H,26,27)	LEMNXUDOGRWKTA-UHFFFAOYSA-N	287847	US10086000, Example 64::8-bromo-6-(6,7,8,9- tetrahydro-5H- benzo[7]annulen-7- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 64	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287847&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383189	378171407							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549057	O=C(C1CCc2ccccc2CC1)N1Cc2cccnc2Nc2ccc(cc12)C(=O)N1Cc2ccccc2C1	InChI=1S/C33H30N4O2/c38-32(36-19-26-8-3-4-9-27(26)20-36)25-15-16-29-30(18-25)37(21-28-10-5-17-34-31(28)35-29)33(39)24-13-11-22-6-1-2-7-23(22)12-14-24/h1-10,15-18,24H,11-14,19-21H2,(H,34,35)	NVUJAEQMFBMWTJ-UHFFFAOYSA-N	287848	US10086000, Example 65::8-(1,3-dihydro-2H- isoindol-2-ylcarbonyl)-6- (6,7,8,9-tetrahydro-5H- benzo[7]annulen-7- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 65	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287848	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287848&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383191	378171408							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549058	Oc1cccc2Nc3ncccc3CN(C(=O)C3CCc4ccccc4CC3)c12	InChI=1S/C24H23N3O2/c28-21-9-3-8-20-22(21)27(15-19-7-4-14-25-23(19)26-20)24(29)18-12-10-16-5-1-2-6-17(16)11-13-18/h1-9,14,18,28H,10-13,15H2,(H,25,26)	HLWYVAQAORQNPE-UHFFFAOYSA-N	287849	US10086000, Example 66::6-(6,7,8,9-tetrahydro-5H- benzo[7]annulen-7- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b] [1,5]benzodiazepin-7-ol::US10508108, Example 66	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287849&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383192	378171409							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549059	FC1(F)C2CCC1CC(C2)C(=O)N1Cc2cccnc2Nc2ccccc12	InChI=1S/C21H21F2N3O/c22-21(23)15-7-8-16(21)11-14(10-15)20(27)26-12-13-4-3-9-24-19(13)25-17-5-1-2-6-18(17)26/h1-6,9,14-16H,7-8,10-12H2,(H,24,25)	VZYNKLSHDTXNNA-UHFFFAOYSA-N	287812	US10086000, Example 30::6-[(8,8- difluorobicyclo[3.2.1]oct- 3-yl)carbonyl]-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10086000, Example 67::US10508108, Example 67	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1767					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287812&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132230247	378171378							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549060	O=C(C1CCc2ccccc2CC1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1	InChI=1S/C28H30N4O2/c33-28(22-9-7-20-4-1-2-5-21(20)8-10-22)32-19-23-6-3-13-29-27(23)30-25-12-11-24(18-26(25)32)31-14-16-34-17-15-31/h1-6,11-13,18,22H,7-10,14-17,19H2,(H,29,30)	ZGJIUUQQZUDAKL-UHFFFAOYSA-N	287851	US10086000, Example 68::8-morpholin-4-yl-6- (6,7,8,9-tetrahydro-5H- benzo[7]annulen-7- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 68	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287851&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383387	378171410							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549061	O=C(C1CCCCC11CC1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1	InChI=1S/C25H30N4O2/c30-24(20-5-1-2-8-25(20)9-10-25)29-17-18-4-3-11-26-23(18)27-21-7-6-19(16-22(21)29)28-12-14-31-15-13-28/h3-4,6-7,11,16,20H,1-2,5,8-10,12-15,17H2,(H,26,27)	NBZIYSGRNFIGCV-UHFFFAOYSA-N	287852	US10086000, Example 69::8-morpholin-4-yl-6- (spiro[2.5]oct-4- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 69	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1905					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287852&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132230268	378171411							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549062	CC1CC(C2CCCC12)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1	InChI=1S/C26H32N4O2/c1-17-14-22(21-6-2-5-20(17)21)26(31)30-16-18-4-3-9-27-25(18)28-23-8-7-19(15-24(23)30)29-10-12-32-13-11-29/h3-4,7-9,15,17,20-22H,2,5-6,10-14,16H2,1H3,(H,27,28)	HLSWWLWMDNUWRS-UHFFFAOYSA-N	287853	US10086000, Example 70::6-[(3- methyloctahydropentalen- 1-yl)carbonyl]-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 70	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 77.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287853&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132230241	378171412							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549063	O=C([C@H]1CC[C@H]2CCC[C@@H]12)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C25H30N4O2/c30-25(21-8-6-17-3-1-5-20(17)21)29-16-18-4-2-10-26-24(18)27-22-9-7-19(15-23(22)29)28-11-13-31-14-12-28/h2,4,7,9-10,15,17,20-21H,1,3,5-6,8,11-14,16H2,(H,26,27)	GFNNTYKPDNITHZ-UHFFFAOYSA-N	287854	US10086000, Example 71::8-morpholin-4-yl-6- [(1S,3aR,6aR)- octahydropentalen-1- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 71	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 85.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287854&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383388	378171413							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549064	O=C([C@@H]1CC[C@@H]2CCC[C@H]12)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C25H30N4O2/c30-25(21-8-6-17-3-1-5-20(17)21)29-16-18-4-2-10-26-24(18)27-22-9-7-19(15-23(22)29)28-11-13-31-14-12-28/h2,4,7,9-10,15,17,20-21H,1,3,5-6,8,11-14,16H2,(H,26,27)	GFNNTYKPDNITHZ-UHFFFAOYSA-N	287855	US10086000, Example 72::8-morpholin-4-yl-6- [(1R,3aS,6aS)- octahydropentalen-1- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b] [1,5]benzodiazepine::US10508108, Example 72	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 400					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287855&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383391	378171414							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549065	O=C([C@@H]1CC[C@H]2CCC[C@@H]12)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C25H30N4O2/c30-25(21-8-6-17-3-1-5-20(17)21)29-16-18-4-2-10-26-24(18)27-22-9-7-19(15-23(22)29)28-11-13-31-14-12-28/h2,4,7,9-10,15,17,20-21H,1,3,5-6,8,11-14,16H2,(H,26,27)	GFNNTYKPDNITHZ-UHFFFAOYSA-N	287856	US10086000, Example 73::8-morpholin-4-yl-6- [(1R,3aR,6aR)- octahydropentalen-1- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 73	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 700					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287856&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383389	378171415							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549066	O=C([C@H]1CC[C@@H]2CCC[C@H]12)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C25H30N4O2/c30-25(21-8-6-17-3-1-5-20(17)21)29-16-18-4-2-10-26-24(18)27-22-9-7-19(15-23(22)29)28-11-13-31-14-12-28/h2,4,7,9-10,15,17,20-21H,1,3,5-6,8,11-14,16H2,(H,26,27)	GFNNTYKPDNITHZ-UHFFFAOYSA-N	287857	US10086000, Example 74::8-morpholin-4-yl-6- [(1S,3aS,6aS)- octahydropentalen-1- ylcarbonyl]-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 74	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 79.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287857&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383160	378171416							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549067	FC1CCN(CC1)c1ccc2Nc3ncccc3CN(C(=O)[C@H]3COc4ccccc4O3)c2c1 |r|	InChI=1S/C26H25FN4O3/c27-18-9-12-30(13-10-18)19-7-8-20-21(14-19)31(15-17-4-3-11-28-25(17)29-20)26(32)24-16-33-22-5-1-2-6-23(22)34-24/h1-8,11,14,18,24H,9-10,12-13,15-16H2,(H,28,29)	SZIYWKTUGSKKCQ-UHFFFAOYSA-N	287858	US10086000, Example 75::6-[(2R)-2,3-dihydro-1,4- benzodioxin-2-ylcarbonyl]- 8-(4-fluoropiperidin-1-yl)- 6,11-dihydro-5H- pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 75	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 69.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287858&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121391510	378171417							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549068	O=C([C@H]1COc2ccccc2O1)N1Cc2cccnc2Nc2ccc(cc12)N1C[C@@H]2CC[C@H](C1)O2 |r|	InChI=1S/C27H26N4O4/c32-27(25-16-33-23-5-1-2-6-24(23)35-25)31-13-17-4-3-11-28-26(17)29-21-10-7-18(12-22(21)31)30-14-19-8-9-20(15-30)34-19/h1-7,10-12,19-20,25H,8-9,13-16H2,(H,28,29)	PWKISEGQPBJCJW-UHFFFAOYSA-N	287859	US10086000, Example 76::6-[(2R)-2,3-dihydro-1,4- benzodioxin-2-ylcarbonyl]- 8-[(1R,5S)-8-oxa-3- azabicyclo[3.2.1]oct-3-yl]- 6,11-dihydro-5H- pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 76	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287859&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383159	378171418							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549069	CCO[C@H]1CC[C@H]2[C@@H]1CC[C@H]2C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C27H34N4O3/c1-2-34-25-10-8-20-21(25)6-7-22(20)27(32)31-17-18-4-3-11-28-26(18)29-23-9-5-19(16-24(23)31)30-12-14-33-15-13-30/h3-5,9,11,16,20-22,25H,2,6-8,10,12-15,17H2,1H3,(H,28,29)	RDYXQLCQGOAUHV-UHFFFAOYSA-N	287860	US10086000, Example 77::6-{[(1R,3aS,4S,6aS)-4- ethoxyoctahydropentalen- 1-yl]carbonyl}-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 77	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 60.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287860&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383157	378171419							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549070	CCO[C@@H]1CC[C@H]2[C@@H]1CC[C@H]2C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C27H34N4O3/c1-2-34-25-10-8-20-21(25)6-7-22(20)27(32)31-17-18-4-3-11-28-26(18)29-23-9-5-19(16-24(23)31)30-12-14-33-15-13-30/h3-5,9,11,16,20-22,25H,2,6-8,10,12-15,17H2,1H3,(H,28,29)	RDYXQLCQGOAUHV-UHFFFAOYSA-N	287861	US10086000, Example 78::6-{[(1R,3aS,4R,6aS)-4- ethoxyoctahydropentalen- 1-yl]carbonyl}-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 78	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 309					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287861&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383158	378171420							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549071	O=C([C@H]1COc2ccccc2O1)N1Cc2cccnc2Nc2ccc(cc12)N1C[C@@H]2C[C@H]1CO2 |r|	InChI=1S/C26H24N4O4/c31-26(24-15-33-22-5-1-2-6-23(22)34-24)30-12-16-4-3-9-27-25(16)28-20-8-7-17(11-21(20)30)29-13-19-10-18(29)14-32-19/h1-9,11,18-19,24H,10,12-15H2,(H,27,28)	JJRUFULQMMVBLK-UHFFFAOYSA-N	287862	US10086000, Example 79::6-[(2R)-2,3-dihydro-1,4- benzodioxin-2-ylcarbonyl]- 8-[(1S,4S)-2-oxa-5- azabicyclo[2.2.1]hept-5- yl]-6,11-dihydro-5H- pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 79	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 64.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287862&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132230302	378171421							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549072	CC(C)(C)c1ccc2OC(COc2c1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1	InChI=1S/C29H32N4O4/c1-29(2,3)20-6-9-24-25(15-20)36-18-26(37-24)28(34)33-17-19-5-4-10-30-27(19)31-22-8-7-21(16-23(22)33)32-11-13-35-14-12-32/h4-10,15-16,26H,11-14,17-18H2,1-3H3,(H,30,31)	NBVBSNKCSHNIBR-UHFFFAOYSA-N	287863	US10086000, Example 80::6-[(6-tert-butyl-2,3- dihydro-1,4-benzodioxin- 2-yl)carbonyl]-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 80	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 176					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287863&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383211	378171422							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549073	Clc1ccc2O[C@H](COc2c1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C25H23ClN4O4/c26-17-3-6-21-22(12-17)33-15-23(34-21)25(31)30-14-16-2-1-7-27-24(16)28-19-5-4-18(13-20(19)30)29-8-10-32-11-9-29/h1-7,12-13,23H,8-11,14-15H2,(H,27,28)	CNDOGTNLWGSFMH-UHFFFAOYSA-N	287864	US10086000, Example 81::6-{[(2R)-6-chloro-2,3- dihydro-1,4-benzodioxin- 2-yl]carbonyl}-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287864&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383207	378171423							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549074	O=C(C1COC2CCCCC2O1)N1Cc2cccnc2Nc2ccc(cc12)N1CC2CCC(C1)O2	InChI=1S/C27H32N4O4/c32-27(25-16-33-23-5-1-2-6-24(23)35-25)31-13-17-4-3-11-28-26(17)29-21-10-7-18(12-22(21)31)30-14-19-8-9-20(15-30)34-19/h3-4,7,10-12,19-20,23-25H,1-2,5-6,8-9,13-16H2,(H,28,29)	BZMCEZPNQMNBRP-UHFFFAOYSA-N	287865	US10086000, Example 82::6-(octahydro-1,4- benzodioxin-2-ylcarbonyl)- 8-(8-oxa-3- azabicyclo[3.2.1]oct-3-yl)- 6,11-dihydro-5H- pyrido[2,3-b] [1,5]benzodiazepine::US10508108, Example 82	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287865&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383210	378171424							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549075	CO[C@@H]1CC[C@@H]2[C@H]1CC[C@@H]2C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CC2CCC(C1)O2 |r|	InChI=1S/C28H34N4O3/c1-34-26-11-9-21-22(26)7-8-23(21)28(33)32-14-17-3-2-12-29-27(17)30-24-10-4-18(13-25(24)32)31-15-19-5-6-20(16-31)35-19/h2-4,10,12-13,19-23,26H,5-9,11,14-16H2,1H3,(H,29,30)	RIVWKJJJHQAAAF-UHFFFAOYSA-N	287866	US10086000, Example 83::6-{[(1S,3aR,4R,6aR)-4- methoxyoctahydropentalen- 1-yl]carbonyl}-8-(8-oxa- 3-azabicyclo[3.2.1]oct-3- yl)-6,11-dihydro-5H- pyrido[2,3-b] [1,5]benzodiazepine::US10508108, Example 83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 48.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287866&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383212	378171425							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549076	CCO[C@@H]1CC[C@@H]2[C@H]1CC[C@@H]2C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1C[C@@H]2C[C@H]1CO2 |r,THB:25:28:33.34:31|	InChI=1S/C28H34N4O3/c1-2-34-26-10-8-21-22(26)6-7-23(21)28(33)32-14-17-4-3-11-29-27(17)30-24-9-5-18(13-25(24)32)31-15-20-12-19(31)16-35-20/h3-5,9,11,13,19-23,26H,2,6-8,10,12,14-16H2,1H3,(H,29,30)	RJKLTGMGINQZDR-UHFFFAOYSA-N	287867	US10086000, Example 84::6-{[(1S,3aR,4R,6aR)-4- ethoxyoctahydropentalen- 1-yl]carbonyl}-8-[(1S,4S)- 2-oxa-5- azabicyclo[2.2.1]hept-5- yl]-6,11-dihydro-5H- pyrido[2,3-b] [1,5]benzodiazepine::US10508108, Example 84	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 56.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287867&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132230285	378171426							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549077	CCO[C@@H]1CC[C@H]2[C@@H]1CC[C@H]2C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1C[C@@H]2C[C@H]1CO2 |r,THB:25:28:33.34:31|	InChI=1S/C28H34N4O3/c1-2-34-26-10-8-21-22(26)6-7-23(21)28(33)32-14-17-4-3-11-29-27(17)30-24-9-5-18(13-25(24)32)31-15-20-12-19(31)16-35-20/h3-5,9,11,13,19-23,26H,2,6-8,10,12,14-16H2,1H3,(H,29,30)	RJKLTGMGINQZDR-UHFFFAOYSA-N	287868	US10086000, Example 85::6-{[(1R,3aS,4R,6aS)-4- ethoxyoctahydropentalen- 1-yl]carbonyl}-8-[(1S,4S)- 2-oxa-5- azabicyclo[2.2.1]hept-5- yl]-6,11-dihydro-5H- pyrido[2,3-b] [1,5]benzodiazepine::US10508108, Example 85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 64.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287868&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132230294	378171427							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549078	COC1CC2(C1)CC(C2)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |(7.11,5.17,;5.62,5.57,;4.53,4.48,;4.53,2.94,;2.99,2.94,;2.99,4.48,;2.99,1.4,;1.45,1.4,;1.45,2.94,;.36,.31,;-1.12,.71,;.76,-1.18,;2.26,-1.52,;2.93,-2.91,;4.47,-2.79,;5.34,-4.07,;4.67,-5.45,;3.13,-5.57,;2.26,-4.3,;.76,-4.64,;-.44,-3.68,;-1.77,-4.45,;-3.11,-3.68,;-3.11,-2.14,;-1.77,-1.37,;-.44,-2.14,;-4.44,-1.37,;-4.44,.17,;-5.78,.94,;-7.11,.17,;-7.11,-1.37,;-5.78,-2.14,)|	InChI=1S/C25H30N4O3/c1-31-20-14-25(15-20)12-18(13-25)24(30)29-16-17-3-2-6-26-23(17)27-21-5-4-19(11-22(21)29)28-7-9-32-10-8-28/h2-6,11,18,20H,7-10,12-16H2,1H3,(H,26,27)	SPEYWFJYAIRBRE-UHFFFAOYSA-N	287869	US10086000, Example 86::6-[(6-Methoxyspiro[3.3]hept-2-yl)carbonyl]-8-morpholin-4-yl-6,11-dihydro-5Hpyrido[2,3-b][1,5]benzodiazepine::US10508108, Example 86	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1915					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287869&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121380079	378171428							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549079	CCOC1CC2(C1)CC(C2)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |(6.64,6.43,;5.87,5.1,;4.33,5.1,;3.56,3.76,;3.96,2.28,;2.47,1.88,;2.07,3.36,;2.87,.39,;1.38,-.01,;.98,1.48,;.61,-1.34,;-.93,-1.34,;1.38,-2.68,;2.92,-2.68,;3.88,-3.88,;5.35,-3.43,;6.48,-4.47,;6.14,-5.98,;4.67,-6.43,;3.54,-5.38,;2.15,-6.05,;.77,-5.38,;-.36,-6.43,;-1.84,-5.98,;-2.18,-4.47,;-1.05,-3.43,;.42,-3.88,;-3.67,-4.08,;-4.06,-2.59,;-5.55,-2.19,;-6.64,-3.28,;-6.24,-4.77,;-4.75,-5.16,)|	InChI=1S/C26H32N4O3/c1-2-33-21-15-26(16-21)13-19(14-26)25(31)30-17-18-4-3-7-27-24(18)28-22-6-5-20(12-23(22)30)29-8-10-32-11-9-29/h3-7,12,19,21H,2,8-11,13-17H2,1H3,(H,27,28)	AMIGYJGBJDSKNV-UHFFFAOYSA-N	287870	US10086000, Example 87::6-[(6- ethoxyspiro[3.3]hept-2- yl)carbonyl]-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1504					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287870&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132230303	378171429							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549080	CC(C)OC1CC2(C1)CC(C2)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |(6.64,6.43,;5.87,5.1,;6.64,3.76,;4.33,5.1,;3.56,3.76,;3.96,2.28,;2.47,1.88,;2.07,3.36,;2.87,.39,;1.38,-.01,;.98,1.48,;.61,-1.34,;-.93,-1.34,;1.38,-2.68,;2.92,-2.68,;3.88,-3.88,;5.35,-3.43,;6.48,-4.47,;6.14,-5.98,;4.67,-6.43,;3.54,-5.38,;2.15,-6.05,;.77,-5.38,;-.36,-6.43,;-1.84,-5.98,;-2.18,-4.47,;-1.05,-3.43,;.42,-3.88,;-3.67,-4.08,;-4.06,-2.59,;-5.55,-2.19,;-6.64,-3.28,;-6.24,-4.77,;-4.75,-5.16,)|	InChI=1S/C27H34N4O3/c1-18(2)34-22-15-27(16-22)13-20(14-27)26(32)31-17-19-4-3-7-28-25(19)29-23-6-5-21(12-24(23)31)30-8-10-33-11-9-30/h3-7,12,18,20,22H,8-11,13-17H2,1-2H3,(H,28,29)	GGEMIFVPTWHRPS-UHFFFAOYSA-N	287871	US10086000, Example 88::6-{[6-(1- methylethoxy)spiro[3.3] hept-2-yl]carbonyl}-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 88	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1037					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287871&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132230271	378171430							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549081	CC1CN(C1)C(=O)C12CCC(CC1)(CC2)C(=O)N1Cc2cccnc2Nc2ccccc12	InChI=1S/C26H30N4O2/c1-18-15-29(16-18)23(31)25-8-11-26(12-9-25,13-10-25)24(32)30-17-19-5-4-14-27-22(19)28-20-6-2-3-7-21(20)30/h2-7,14,18H,8-13,15-17H2,1H3,(H,27,28)	BTLDQLASAZXKGG-UHFFFAOYSA-N	287872	US10086000, Example 89::6-({4-[(3-Methylazetidin-1-yl)carbonyl]bicyclo[2.2.2]oct-1-yl}carbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine::US10508108, Example 89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4200					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287872&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121380066	378171431							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549082	CC1(F)CN(C1)C(=O)C12CCC(CC1)(CC2)C(=O)N1Cc2cccnc2Nc2ccccc12	InChI=1S/C26H29FN4O2/c1-24(27)16-30(17-24)22(32)25-8-11-26(12-9-25,13-10-25)23(33)31-15-18-5-4-14-28-21(18)29-19-6-2-3-7-20(19)31/h2-7,14H,8-13,15-17H2,1H3,(H,28,29)	SZNXYSAGXFXGHO-UHFFFAOYSA-N	287873	US10086000, Example 90::6-({4-[(3-fluoro-3- methylazetidin-1- yl)carbonyl]bicyclo[2.2.2]oct- 1-yl}carbonyl)-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 90	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3845					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287873&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383254	378171432							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549083	FC1(F)CN(C1)C(=O)C12CCC(CC1)(CC2)C(=O)N1Cc2cccnc2Nc2ccccc12	InChI=1S/C25H26F2N4O2/c26-25(27)15-30(16-25)21(32)23-7-10-24(11-8-23,12-9-23)22(33)31-14-17-4-3-13-28-20(17)29-18-5-1-2-6-19(18)31/h1-6,13H,7-12,14-16H2,(H,28,29)	LBHMPSDEVYFZHI-UHFFFAOYSA-N	287874	US10086000, Example 91::6-({4-[(3,3-difluoroazetidin- 1- yl)carbonyl]bicyclo[2.2.2]oct- 1-yl}carbonyl)-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5787					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287874&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383272	378171433							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549084	FC1CN(C1)C(=O)C12CCC(CC1)(CC2)C(=O)N1Cc2cccnc2Nc2ccccc12	InChI=1S/C25H27FN4O2/c26-18-15-29(16-18)22(31)24-7-10-25(11-8-24,12-9-24)23(32)30-14-17-4-3-13-27-21(17)28-19-5-1-2-6-20(19)30/h1-6,13,18H,7-12,14-16H2,(H,27,28)	QEFHZEGAOJQUMK-UHFFFAOYSA-N	287875	US10086000, Example 92::6-({4-[(3-fluoroazetidin-1- yl)carbonyl]bicyclo[2.2.2]oct- 1-yl}carbonyl)-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 92	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4516					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287875&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383253	378171434							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549085	O=C(N1CCC1)C12CCC(CC1)(CC2)C(=O)N1Cc2cccnc2Nc2ccccc12	InChI=1S/C25H28N4O2/c30-22(28-15-4-16-28)24-8-11-25(12-9-24,13-10-24)23(31)29-17-18-5-3-14-26-21(18)27-19-6-1-2-7-20(19)29/h1-3,5-7,14H,4,8-13,15-17H2,(H,26,27)	HUUAEPLPXSFGAW-UHFFFAOYSA-N	287876	US10086000, Example 93::6-{[4-(azetidin-1- ylcarbonyl)bicyclo[2.2.2]oct- 1-yl]carbonyl}-6,11-dihydro- 5H-pyrido[2,3-b] [1,5]benzodiazepine::US10508108, Example 93	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12250					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287876&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383256	378171435							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549086	CC(C)N(C)C(=O)C12CCC(CC1)(CC2)C(=O)N1Cc2cccnc2Nc2ccccc12	InChI=1S/C26H32N4O2/c1-18(2)29(3)23(31)25-10-13-26(14-11-25,15-12-25)24(32)30-17-19-7-6-16-27-22(19)28-20-8-4-5-9-21(20)30/h4-9,16,18H,10-15,17H2,1-3H3,(H,27,28)	RJYSJEFSQNWTNA-UHFFFAOYSA-N	287877	US10086000, Example 94::4-(5,11-dihydro-6H- pyrido[2,3-b]  [1,5]benzodiazepin-6- ylcarbonyl)-N-methyl-N-(1- methylethyl)bicyclo[2.2.2] octane-1-carboxamide::US10508108, Example 94	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 635					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287877&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383259	378171436							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549087	O=C(C1CCc2ccccc2C1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1	InChI=1S/C27H28N4O2/c32-27(21-8-7-19-4-1-2-5-20(19)16-21)31-18-22-6-3-11-28-26(22)29-24-10-9-23(17-25(24)31)30-12-14-33-15-13-30/h1-6,9-11,17,21H,7-8,12-16,18H2,(H,28,29)	KRRBQFQTSVYSHK-UHFFFAOYSA-N	287878	US10086000, Example 95::8-Morpholin-4-yl-6-(1,2,3,4-tetrahydronaphthalen-2-ylcarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine::US10508108, Example 95	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 91.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287878&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121380034	378171437							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549088	COc1cccc2CCC(Cc12)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1	InChI=1S/C28H30N4O3/c1-34-26-6-2-4-19-7-8-20(16-23(19)26)28(33)32-18-21-5-3-11-29-27(21)30-24-10-9-22(17-25(24)32)31-12-14-35-15-13-31/h2-6,9-11,17,20H,7-8,12-16,18H2,1H3,(H,29,30)	CAAIDMYMHYNOTH-UHFFFAOYSA-N	287879	US10086000, Example 96::6-[(8-methoxy-1,2,3,4- tetrahydronaphthalen-2- yl)carbonyl]-8-morpholin-4- yl-6,11-dihydro-5H- pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 96	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 117					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287879&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383155	378171438							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549089	O=C(C1COc2ccccc2C1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1	InChI=1S/C26H26N4O3/c31-26(20-14-18-4-1-2-6-24(18)33-17-20)30-16-19-5-3-9-27-25(19)28-22-8-7-21(15-23(22)30)29-10-12-32-13-11-29/h1-9,15,20H,10-14,16-17H2,(H,27,28)	JMXMRRMQDVMYPN-UHFFFAOYSA-N	287880	US10086000, Example 97::6-(3,4-dihydro-2H- chromen-3-ylcarbonyl)-8- morpholin-4-yl-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10508108, Example 97	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 141					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287880&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383408	378171439							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549090	O=C(C1Cc2ccccc2NC1=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1	InChI=1S/C26H25N5O3/c32-25-20(14-17-4-1-2-6-21(17)29-25)26(33)31-16-18-5-3-9-27-24(18)28-22-8-7-19(15-23(22)31)30-10-12-34-13-11-30/h1-9,15,20H,10-14,16H2,(H,27,28)(H,29,32)	IMWCTODXZFTFNP-UHFFFAOYSA-N	287881	US10086000, Example 98::3-[(8-morpholin-4-yl-5,11- dihydro-6H-pyrido[2,3- b][1,5]benzodiazepin-6- yl)carbonyl]-3,4- dihydroquinolin-2(1H)-one::US10508108, Example 98	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3608					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287881&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383407	378171440							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549091	Cn1cc(cn1)-c1ccc2Nc3ncccc3CN(C(=O)C3CCc4ccccc4CC3)c2c1	InChI=1S/C28H27N5O/c1-32-17-24(16-30-32)22-12-13-25-26(15-22)33(18-23-7-4-14-29-27(23)31-25)28(34)21-10-8-19-5-2-3-6-20(19)9-11-21/h2-7,12-17,21H,8-11,18H2,1H3,(H,29,31)	OGLGWKPYRFNACV-UHFFFAOYSA-N	287882	US10086000, Example 99::8-(1-Methyl-1H-pyrazol-4-yl)-6-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-ylcarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine::US10508108, Example 99	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287882&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121380046	378171441							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549092	Cc1ncc(-c2ccc3Nc4ncccc4CN(C(=O)C4CCc5ccccc5CC4)c3c2)n1C	InChI=1S/C29H29N5O/c1-19-31-17-27(33(19)2)23-13-14-25-26(16-23)34(18-24-8-5-15-30-28(24)32-25)29(35)22-11-9-20-6-3-4-7-21(20)10-12-22/h3-8,13-17,22H,9-12,18H2,1-2H3,(H,30,32)	SXKDRXACVQKEMA-UHFFFAOYSA-N	287883	US10086000, Example 100::8-(1,2-dimethyl-1H- imidazol-5-yl)-6-(6,7,8,9- tetrahydro-5H- benzo[7]annulen-7- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b] [1,5]benzodiazepine::US10508108, Example 100	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287883&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383433	378171442							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549093	Cn1nccc1-c1ccc2Nc3ncccc3CN(C(=O)C3CCc4ccccc4CC3)c2c1	InChI=1S/C28H27N5O/c1-32-25(14-16-30-32)22-12-13-24-26(17-22)33(18-23-7-4-15-29-27(23)31-24)28(34)21-10-8-19-5-2-3-6-20(19)9-11-21/h2-7,12-17,21H,8-11,18H2,1H3,(H,29,31)	UGPNXLIHHNDMRR-UHFFFAOYSA-N	287884	US10086000, Example 101::8-(1-methyl-1H-pyrazol-5- yl)-6-(6,7,8,9-tetrahydro- 5H-benzo[7]annulen-7- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287884&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383436	378171443							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549094	Cc1nc(C)c(s1)-c1ccc2Nc3ncccc3CN(C(=O)C3CCc4ccccc4CC3)c2c1	InChI=1S/C29H28N4OS/c1-18-27(35-19(2)31-18)23-13-14-25-26(16-23)33(17-24-8-5-15-30-28(24)32-25)29(34)22-11-9-20-6-3-4-7-21(20)10-12-22/h3-8,13-16,22H,9-12,17H2,1-2H3,(H,30,32)	ZONAVWZYMMHOQD-UHFFFAOYSA-N	287885	US10086000, Example 102::8-(2,4-dimethyl-1,3-thiazol- 5-yl)-6-(6,7,8,9-tetrahydro- 5H-benzo[7]annulen-7- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b] [1,5]benzodiazepine::US10508108, Example 102	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 6.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287885&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383434	378171444							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549095	O=C(C1CCc2ccccc2CC1)N1Cc2cccnc2Nc2ccc(cc12)-c1cnoc1	InChI=1S/C27H24N4O2/c32-27(20-9-7-18-4-1-2-5-19(18)8-10-20)31-16-22-6-3-13-28-26(22)30-24-12-11-21(14-25(24)31)23-15-29-33-17-23/h1-6,11-15,17,20H,7-10,16H2,(H,28,30)	LFUXLJPXXOFIHA-UHFFFAOYSA-N	287886	US10086000, Example 103::8-isoxazol-4-yl-6-(6,7,8,9- tetrahydro-5H- benzo[7]annulen-7- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b] [1,5]benzodiazepine::US10508108, Example 103	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287886&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383432	378171445							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549096	CCOc1cncc(c1)-c1ccc2Nc3ncccc3CN(C(=O)C3CCc4ccccc4CC3)c2c1	InChI=1S/C31H30N4O2/c1-2-37-27-16-26(18-32-19-27)24-13-14-28-29(17-24)35(20-25-8-5-15-33-30(25)34-28)31(36)23-11-9-21-6-3-4-7-22(21)10-12-23/h3-8,13-19,23H,2,9-12,20H2,1H3,(H,33,34)	FHPNBCQTPCLRAU-UHFFFAOYSA-N	287887	US10086000, Example 104::8-(5-Ethoxypyridin-3-yl)-6-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-ylcarbonyl)-6,11-dihydro-5H-pyrido [2,3-b][1,5]benzodiazepine::US10508108, Example 104	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287887	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287887&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121380041	378171446							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549097	O=C([C@H]1COc2ccccc2O1)N1Cc2cccnc2Nc2ccc(cc12)C1CCOCC1 |r|	InChI=1S/C26H25N3O4/c30-26(24-16-32-22-5-1-2-6-23(22)33-24)29-15-19-4-3-11-27-25(19)28-20-8-7-18(14-21(20)29)17-9-12-31-13-10-17/h1-8,11,14,17,24H,9-10,12-13,15-16H2,(H,27,28)	AXVWLIZLYDFWHO-UHFFFAOYSA-N	287888	US10086000, Example 105::(R)-(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)(8-(tetrahydro-2H-pyran-4-yl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)methanone::US10508108, Example 105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 36.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287888&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132230284	378171447							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549098	OC1CCN(C1)c1cc(ccn1)-c1ccc2Nc3ncccc3CN(C(=O)C3CCc4ccccc4CC3)c2c1	InChI=1S/C33H33N5O2/c39-28-14-17-37(21-28)31-19-26(13-16-34-31)25-11-12-29-30(18-25)38(20-27-6-3-15-35-32(27)36-29)33(40)24-9-7-22-4-1-2-5-23(22)8-10-24/h1-6,11-13,15-16,18-19,24,28,39H,7-10,14,17,20-21H2,(H,35,36)	DAPKTLAEEZLXRK-UHFFFAOYSA-N	287889	US10086000, Example 106::1-{4-[6-(6,7,8,9-tetrahydro- 5H-benzo[7]annulen-7- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b] [1,5]benzodiazepin-8- yl]pyridin-2-yl}pyrrolidin- 3-ol::US10508108, Example 106	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287889&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383412	378171448							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549099	CN(C)c1cc(ccn1)-c1ccc2Nc3ncccc3CN(C(=O)C3CCc4ccccc4CC3)c2c1	InChI=1S/C31H31N5O/c1-35(2)29-19-25(15-17-32-29)24-13-14-27-28(18-24)36(20-26-8-5-16-33-30(26)34-27)31(37)23-11-9-21-6-3-4-7-22(21)10-12-23/h3-8,13-19,23H,9-12,20H2,1-2H3,(H,33,34)	SSHNWWXNSWLUGE-UHFFFAOYSA-N	287890	US10086000, Example 107::N,N-dimethyl-4-[6-(6,7,8,9- tetrahydro-5H- benzo[7]annulen-7- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b]  [1,5]benzodiazepin-8- yl]pyridin-2-amine::US10508108, Example 107	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287890&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383414	378171449							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549100	COc1ccc(c(C)n1)-c1ccc2Nc3ncccc3CN(C(=O)C3CCc4ccccc4CC3)c2c1	InChI=1S/C31H30N4O2/c1-20-26(14-16-29(33-20)37-2)24-13-15-27-28(18-24)35(19-25-8-5-17-32-30(25)34-27)31(36)23-11-9-21-6-3-4-7-22(21)10-12-23/h3-8,13-18,23H,9-12,19H2,1-2H3,(H,32,34)	DHVRWBAGXDPIJY-UHFFFAOYSA-N	287891	US10086000, Example 108::8-(6-methoxy-2- methylpyridin-3-yl)-6- (6,7,8,9-tetrahydro-5H- benzo[7]annulen-7- ylcarbonyl)-6,11-dihydro- 5H-pyrido[2,3-b] [1,5]benzodiazepine::US10508108, Example 108	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 6.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287891&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383413	378171450							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549101	Cn1ccc(n1)-c1ccc2Nc3ncccc3CN(C(=O)[C@H]3COc4ccccc4O3)c2c1 |r|	InChI=1S/C25H21N5O3/c1-29-12-10-18(28-29)16-8-9-19-20(13-16)30(14-17-5-4-11-26-24(17)27-19)25(31)23-15-32-21-6-2-3-7-22(21)33-23/h2-13,23H,14-15H2,1H3,(H,26,27)	JBFLHFSHRCEVLO-UHFFFAOYSA-N	287892	US10086000, Example 109::6-[(2R)-2,3-dihydro-1,4- benzodioxin-2-ylcarbonyl]- 8-(1-methyl-1H-pyrazol-3- yl)-6,11-dihydro-5H- pyrido[2,3-b]  [1,5]benzodiazepine::US10508108, Example 109	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 160					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287892&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383415	378171451							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549102	CCOc1ccc2Nc3ncccc3CN(C(=O)C3CCc4ccccc4CC3)c2n1	InChI=1S/C25H26N4O2/c1-2-31-22-14-13-21-24(28-22)29(16-20-8-5-15-26-23(20)27-21)25(30)19-11-9-17-6-3-4-7-18(17)10-12-19/h3-8,13-15,19H,2,9-12,16H2,1H3,(H,26,27)	FMQGKDVYSZFALS-UHFFFAOYSA-N	287893	US10086000, Example 110::2-Ethoxy-11-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-ylcarbonyl)-10,11-dihydro-5H-dipyrido[2,3-b:2&#8242;,3&#8242;-e][1,4]diazepine::US10508108, Example 110	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287893&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383435	378171452							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549103	FC(F)(F)c1noc(n1)C12CCC(CC1)(CC2)C(=O)N1Cc2cccnc2Nc2ccccc12	InChI=1S/C24H22F3N5O2/c25-24(26,27)19-30-20(34-31-19)22-7-10-23(11-8-22,12-9-22)21(33)32-14-15-4-3-13-28-18(15)29-16-5-1-2-6-17(16)32/h1-6,13H,7-12,14H2,(H,28,29)	WJXYJBSILRDDHC-UHFFFAOYSA-N	287894	US10086000, Example 111::6-({4-[3-(Trifluoromethyl)-1,2,4-oxadiazol-5-yl]bicyclo[2.2.2]oct-1-yl}carbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine::US10508108, Example 111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1873					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287894&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121380070	378171453							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549104	O=C([C@H]1CCCc2ncccc2C1)N1Cc2cccnc2Nc2ccccc12 |r|	InChI=1S/C23H22N4O/c28-23(17-6-3-10-19-16(14-17)7-4-12-24-19)27-15-18-8-5-13-25-22(18)26-20-9-1-2-11-21(20)27/h1-2,4-5,7-9,11-13,17H,3,6,10,14-15H2,(H,25,26)	WJQMAHYRITZZAK-UHFFFAOYSA-N	287895	US10086000, Example 112::6-(6,7,8,9-Tetrahydro-5H-cyclohepta[b]pyridin-6-ylcarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 22550					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287895&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			136215687	378171454							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549105	O=C([C@@H]1CCCc2ncccc2C1)N1Cc2cccnc2Nc2ccccc12 |r|	InChI=1S/C23H22N4O/c28-23(17-6-3-10-19-16(14-17)7-4-12-24-19)27-15-18-8-5-13-25-22(18)26-20-9-1-2-11-21(20)27/h1-2,4-5,7-9,11-13,17H,3,6,10,14-15H2,(H,25,26)	WJQMAHYRITZZAK-UHFFFAOYSA-N	287896	US10086000, Example 113::US10508108, Example 113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 16350					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287896&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			136215688	378171455							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549106	O=C([C@H]1CCCc2cccnc2C1)N1Cc2cccnc2Nc2ccccc12 |r|	InChI=1S/C23H22N4O/c28-23(17-7-3-6-16-8-4-12-24-20(16)14-17)27-15-18-9-5-13-25-22(18)26-19-10-1-2-11-21(19)27/h1-2,4-5,8-13,17H,3,6-7,14-15H2,(H,25,26)	VSRRIGLMRXWSJZ-UHFFFAOYSA-N	287897	US10086000, Example 114	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 894					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287897&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			136215689	378171456							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549107	O=C([C@@H]1CCCc2cccnc2C1)N1Cc2cccnc2Nc2ccccc12 |r|	InChI=1S/C23H22N4O/c28-23(17-7-3-6-16-8-4-12-24-20(16)14-17)27-15-18-9-5-13-25-22(18)26-19-10-1-2-11-21(19)27/h1-2,4-5,8-13,17H,3,6-7,14-15H2,(H,25,26)	VSRRIGLMRXWSJZ-UHFFFAOYSA-N	287898	US10086000, Example 115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 429					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287898&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			136215690	378171457							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549108	CC(C)(O)c1ccc2Nc3ncccc3CN(C(=O)C3CCc4ccccc4CC3)c2c1	InChI=1S/C27H29N3O2/c1-27(2,32)22-13-14-23-24(16-22)30(17-21-8-5-15-28-25(21)29-23)26(31)20-11-9-18-6-3-4-7-19(18)10-12-20/h3-8,13-16,20,32H,9-12,17H2,1-2H3,(H,28,29)	DTNPCFKPBPDCLJ-UHFFFAOYSA-N	287899	US10086000, Example 116::2-[6-(6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-ylcarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-8-yl]propan-2-ol::US10508108, Example 116	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287899&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121380051	378171458							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549109	CN(C)c1ccc2Nc3ncccc3CN(C(=O)C3CCc4ccccc4CC3)c2n1	InChI=1S/C25H27N5O/c1-29(2)22-14-13-21-24(28-22)30(16-20-8-5-15-26-23(20)27-21)25(31)19-11-9-17-6-3-4-7-18(17)10-12-19/h3-8,13-15,19H,9-12,16H2,1-2H3,(H,26,27)	JIWHUECUVLYNPL-UHFFFAOYSA-N	287900	US10086000, Example 117::N,N-Dimethyl-11-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-ylcarbonyl)-10,11-dihydro-5H-dipyrido[2,3-b:2&#8242;,3&#8242;-e][1,4]diazepin-2-amine::US10508108, Example 117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 22.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287900&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121380017	378171459							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549110	O=C(C1CCc2ccccc2CC1)N1Cc2cccnc2Nc2ccc(nc12)N1CCOCC1	InChI=1S/C27H29N5O2/c33-27(21-9-7-19-4-1-2-5-20(19)8-10-21)32-18-22-6-3-13-28-25(22)29-23-11-12-24(30-26(23)32)31-14-16-34-17-15-31/h1-6,11-13,21H,7-10,14-18H2,(H,28,29)	RHVZDZUDQPVWAK-UHFFFAOYSA-N	287901	US10086000, Example 118::2-Morpholin-4-yl-11-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-ylcarbonyl)-10,11-dihydro-5H-dipyrido[2,3-b:2&#8242;,3&#8242;-e][1,4]diazepine::US10508108, Example 118	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 9.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287901	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287901&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383416	378171460							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549111	CC(C)[C@@H]1COC(=O)N1c1ccc2Nc3ncccc3CN(C(=O)[C@]34C[C@H]5C[C@H](C[C@H](C5)C3)C4)c2c1 |r,TLB:32:24:29.30.31:27,THB:25:26:29:33.24.32,25:24:29:26.31.27,22:24:29.30.31:27|	InChI=1S/C29H34N4O3/c1-17(2)25-16-36-28(35)33(25)22-5-6-23-24(11-22)32(15-21-4-3-7-30-26(21)31-23)27(34)29-12-18-8-19(13-29)10-20(9-18)14-29/h3-7,11,17-20,25H,8-10,12-16H2,1-2H3,(H,30,31)	BZXVLITZRZQZMA-UHFFFAOYSA-N	287902	US10086000, Example 119::(4R)-4-(1-Methylethyl)-3-{6-[(3S,5S,7S)-tricyclo[3.3.1.1 3,7 ]dec-1-ylcarbonyl]-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-8-yl}-1,3-oxazolidin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 22.0					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287902&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132230267	378171461							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549112	O=C(C1CCc2ccccc2CC1)N1Cc2cccnc2Nc2ccc(nc12)C1CNC(=O)C1	InChI=1S/C27H27N5O2/c33-24-14-21(15-29-24)22-11-12-23-26(31-22)32(16-20-6-3-13-28-25(20)30-23)27(34)19-9-7-17-4-1-2-5-18(17)8-10-19/h1-6,11-13,19,21H,7-10,14-16H2,(H,28,30)(H,29,33)	QNKVWIAMQYHFMN-UHFFFAOYSA-N	287903	US10086000, Example 120::4-[6-(6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-ylcarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-8-yl]pyrrolidin-2-one::US10508108, Example 120	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287903&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383302	378171462							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549113	O=C(C1CCC2(CCO2)CC1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |(-.24,.93,;1.25,.54,;2.34,1.62,;3.83,1.23,;4.92,2.31,;4.52,3.8,;6.06,3.8,;6.06,5.34,;4.52,5.34,;3.03,4.2,;1.94,3.11,;1.65,-.95,;3.15,-1.29,;3.82,-2.68,;5.36,-2.57,;6.22,-3.84,;5.55,-5.23,;4.02,-5.34,;3.15,-4.07,;1.65,-4.41,;.45,-3.45,;-.89,-4.22,;-2.22,-3.45,;-2.22,-1.91,;-.89,-1.14,;.45,-1.91,;-3.56,-1.14,;-3.56,.4,;-4.89,1.17,;-6.22,.4,;-6.22,-1.14,;-4.89,-1.91,)|	InChI=1S/C25H30N4O3/c30-24(18-5-7-25(8-6-18)9-13-32-25)29-17-19-2-1-10-26-23(19)27-21-4-3-20(16-22(21)29)28-11-14-31-15-12-28/h1-4,10,16,18H,5-9,11-15,17H2,(H,26,27)	VMYFPSMGYLDATH-UHFFFAOYSA-N	287904	US10086000, Example 121::8-Morpholin-4-yl-6-(1-oxaspiro[3.5]non-7-ylcarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine::US10508108, Example 121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 36720					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287904&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121380047	378171463							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549114	O=C(C1CC2(C1)CC(=O)C2)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1	InChI=1S/C24H26N4O3/c29-19-13-24(14-19)11-17(12-24)23(30)28-15-16-2-1-5-25-22(16)26-20-4-3-18(10-21(20)28)27-6-8-31-9-7-27/h1-5,10,17H,6-9,11-15H2,(H,25,26)	WCSCCAQCZREGKE-UHFFFAOYSA-N	287905	US10086000, Example 122::6-[(8-Morpholin-4-yl-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)carbonyl]spiro[3.3]heptan-2-one::US10508108, Example 122	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5126					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287905&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121380064	378171464							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549115	CC1(O)CC2(CC(C2)C(=O)N2Cc3cccnc3Nc3ccc(cc23)N2CCOCC2)C1	InChI=1S/C25H30N4O3/c1-24(31)15-25(16-24)12-18(13-25)23(30)29-14-17-3-2-6-26-22(17)27-20-5-4-19(11-21(20)29)28-7-9-32-10-8-28/h2-6,11,18,31H,7-10,12-16H2,1H3,(H,26,27)	MOVMEFYRHAUKOW-UHFFFAOYSA-N	287906	US10086000, Example 123::2-Methyl-6-[(8-morpholin-4-yl-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl)carbonyl]spiro[3.3]heptan-2-ol::US10508108, Example 123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5961					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287906&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121380052	378171465							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549116	O=C(C1CCc2ccccc2CC1)N1Cc2cccnc2Nc2ccc(cc12)N1CCOC1=O	InChI=1S/C27H26N4O3/c32-26(20-9-7-18-4-1-2-5-19(18)8-10-20)31-17-21-6-3-13-28-25(21)29-23-12-11-22(16-24(23)31)30-14-15-34-27(30)33/h1-6,11-13,16,20H,7-10,14-15,17H2,(H,28,29)	CGXSXBQMFQBBBD-UHFFFAOYSA-N	287907	US10086000, Example 124::3-[6-(6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-ylcarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-8-yl]-1,3-oxazolidin-2-one::US10508108, Example 124	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287907&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383375	378171466							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549117	CC1NC(=O)OC1c1ccc2Nc3ncccc3CN(C(=O)C3CCc4ccccc4CC3)c2c1	InChI=1S/C28H28N4O3/c1-17-25(35-28(34)30-17)21-12-13-23-24(15-21)32(16-22-7-4-14-29-26(22)31-23)27(33)20-10-8-18-5-2-3-6-19(18)9-11-20/h2-7,12-15,17,20,25H,8-11,16H2,1H3,(H,29,31)(H,30,34)	YMISJQJGUWQLMM-UHFFFAOYSA-N	287908	US10086000, Example 125::4-Methyl-5-[6-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-ylcarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-8-yl]-1,3-oxazolidin-2-one::US10508108, Example 125	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287908&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121380033	378171467							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549118	CC(C)[C@@H]1COC(=O)N1c1ccc2Nc3ncccc3CN(C(=O)C3CCc4ccccc4CC3)c2c1 |r|	InChI=1S/C30H32N4O3/c1-19(2)27-18-37-30(36)34(27)24-13-14-25-26(16-24)33(17-23-8-5-15-31-28(23)32-25)29(35)22-11-9-20-6-3-4-7-21(20)10-12-22/h3-8,13-16,19,22,27H,9-12,17-18H2,1-2H3,(H,31,32)	AWIGGJCYCQRXCP-UHFFFAOYSA-N	287909	US10086000, Example 126::(4R)-4-(1-Methylethyl)-3-[6-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-ylcarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-8-yl]-1,3-oxazolidin-2-one::US10508108, Example 126	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287909	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287909&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121380068	378171468							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549119	FC(F)(F)CCc1ccc2Nc3ncccc3CN(C(=O)[C@H]3COc4ccccc4O3)c2c1 |r|	InChI=1S/C24H20F3N3O3/c25-24(26,27)10-9-15-7-8-17-18(12-15)30(13-16-4-3-11-28-22(16)29-17)23(31)21-14-32-19-5-1-2-6-20(19)33-21/h1-8,11-12,21H,9-10,13-14H2,(H,28,29)	LRROYLUTEOAHEC-UHFFFAOYSA-N	287910	US10086000, Example 127::(R)-(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)(8-(3,3,3-trifluoropropyl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)methanone::US10508108, Example 127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 120					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287910&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383346	378171469							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549120	FC(F)(F)c1ccc2Nc3ncccc3CN(C(=O)[C@H]3COc4ccccc4O3)c2c1 |r|	InChI=1S/C22H16F3N3O3/c23-22(24,25)14-7-8-15-16(10-14)28(11-13-4-3-9-26-20(13)27-15)21(29)19-12-30-17-5-1-2-6-18(17)31-19/h1-10,19H,11-12H2,(H,26,27)	PJIDZAKTHRGLCP-UHFFFAOYSA-N	287911	US10086000, Example 128::(R)-(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)(8-(trifluoromethyl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)methanone::US10508108, Example 128	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 170					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287911&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383352	378171470							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549121	FC(F)(F)CN1[C@H]2COC[C@@H]1CC(C2)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1C[C@H]2CCC1CO2 |r,THB:4:5:12.13.11:9.8.7|	InChI=1S/C28H32F3N5O3/c29-28(30,31)16-36-21-8-18(9-22(36)14-38-13-21)27(37)35-11-17-2-1-7-32-26(17)33-24-6-4-19(10-25(24)35)34-12-23-5-3-20(34)15-39-23/h1-2,4,6-7,10,18,20-23H,3,5,8-9,11-16H2,(H,32,33)	GEXOXBINQBHMOE-UHFFFAOYSA-N	287912	US10086000, Example 129::(8-((1R,4R)-2-Oxa-5-azabicyclo[2.2.2]octan-5-yl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)((1R,5 S)-9-(2,2,2-trifluoroethyl)-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 6.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287912&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132245220	378171471							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549122	FC(F)(F)CN1[C@H]2COC[C@@H]1CC(C2)C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1C[C@@H]2CCC1CO2 |r,THB:4:5:12.13.11:9.8.7|	InChI=1S/C28H32F3N5O3/c29-28(30,31)16-36-21-8-18(9-22(36)14-38-13-21)27(37)35-11-17-2-1-7-32-26(17)33-24-6-4-19(10-25(24)35)34-12-23-5-3-20(34)15-39-23/h1-2,4,6-7,10,18,20-23H,3,5,8-9,11-16H2,(H,32,33)	GEXOXBINQBHMOE-UHFFFAOYSA-N	287913	US10086000, Example 130::(8-((1 S,4S)-2-oxa-5-azabicyclo[2.2.2]octan-5-yl)-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)((1R,5 S)-9-(2,2,2-trifluoroethyl)-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5.00					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287913&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132245221	378171472							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
549123	FC(F)(F)CN1C[C@@H]2C[C@H](C1)[C@H]2C(=O)N1Cc2cccnc2Nc2ccc(cc12)N1CCOCC1 |r|	InChI=1S/C25H28F3N5O2/c26-25(27,28)15-31-12-17-10-18(13-31)22(17)24(34)33-14-16-2-1-5-29-23(16)30-20-4-3-19(11-21(20)33)32-6-8-35-9-7-32/h1-5,11,17-18,22H,6-10,12-15H2,(H,29,30)	XSRWMKUIIODORQ-UHFFFAOYSA-N	287914	US10086000, Example 131::Cis[8-(morpholin-4-yl)-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl][3-(2,2,2-trifluoroethyl)-3-azabicyclo[3.1.1]hept-6-yl]methanone::US10508108, Example 131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 114					7.0000	25.00 C	US Patent		10.7270/Q2N58PCG		aid1795750	US10086000	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Parker, Jr., DL; Sciammetta, N; Shao, PP; Sloman, DL; Sun, W; Ujjainwalla, F; Huang, C	10/2/2018	1/17/2019	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=287914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=287914&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121383437	378171473							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564480	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C24H28ClN5O4/c1-14(20-12-18(29-34-20)16-6-8-17(25)9-7-16)27-22-26-11-10-21(28-22)30-19(13-32-23(30)31)15(2)33-24(3,4)5/h6-12,14-15,19H,13H2,1-5H3,(H,26,27,28)	XTMBZOPPDDBHCY-UHFFFAOYSA-N	247479	US9688672, Example 1::US9434719, 1::US10112931, Example 1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1410					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247479	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247479&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415932	346542019							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564481	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1nc(NC(C)c2ncc(o2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C24H27ClFN5O4/c1-13(21-27-11-19(34-21)15-6-8-16(25)9-7-15)29-22-28-10-17(26)20(30-22)31-18(12-33-23(31)32)14(2)35-24(3,4)5/h6-11,13-14,18H,12H2,1-5H3,(H,28,29,30)	IHYYHUMBFQYNAV-UHFFFAOYSA-N	247480	US9688672, Example 2::US9434719, 2::US10112931, Example 2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 406					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247480	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247480&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416257	346542020							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564482	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)c(C)c2)n1 |r|	InChI=1S/C24H29ClN6O4/c1-13-11-16(7-8-17(13)25)20-29-21(35-30-20)14(2)27-22-26-10-9-19(28-22)31-18(12-33-23(31)32)15(3)34-24(4,5)6/h7-11,14-15,18H,12H2,1-6H3,(H,26,27,28)	RISGNMCTDXRSHM-UHFFFAOYSA-N	247481	US9688672, Example 4::US9434719, 4::US10112931, Example 4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1420					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247481&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414642	346542021							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564483	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)c(C)c2)n1 |r|	InChI=1S/C24H29ClN6O4/c1-13-11-16(7-8-17(13)25)20-29-21(35-30-20)14(2)27-22-26-10-9-19(28-22)31-18(12-33-23(31)32)15(3)34-24(4,5)6/h7-11,14-15,18H,12H2,1-6H3,(H,26,27,28)	RISGNMCTDXRSHM-UHFFFAOYSA-N	247481	US9688672, Example 4::US9434719, 4::US10112931, Example 4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2010					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247481&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414642	346542021							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564484	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(C)c2)n1 |r|	InChI=1S/C24H29FN6O4/c1-13-11-16(7-8-17(13)25)20-29-21(35-30-20)14(2)27-22-26-10-9-19(28-22)31-18(12-33-23(31)32)15(3)34-24(4,5)6/h7-11,14-15,18H,12H2,1-6H3,(H,26,27,28)	DCYDNMBZDQIZKQ-UHFFFAOYSA-N	247482	US9688672, Example 5::US9434719, 5::US10112931, Example 5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17800					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247482	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247482&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90413672	346542022							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564485	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(C)c2)n1 |r|	InChI=1S/C24H29FN6O4/c1-13-11-16(7-8-17(13)25)20-29-21(35-30-20)14(2)27-22-26-10-9-19(28-22)31-18(12-33-23(31)32)15(3)34-24(4,5)6/h7-11,14-15,18H,12H2,1-6H3,(H,26,27,28)	DCYDNMBZDQIZKQ-UHFFFAOYSA-N	247482	US9688672, Example 5::US9434719, 5::US10112931, Example 5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3684					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247482	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247482&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90413672	346542022							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564486	COc1cc(ccc1Cl)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)OC(C)(C)C |r|	InChI=1S/C24H29ClN6O5/c1-13(21-29-20(30-36-21)15-7-8-16(25)18(11-15)33-6)27-22-26-10-9-19(28-22)31-17(12-34-23(31)32)14(2)35-24(3,4)5/h7-11,13-14,17H,12H2,1-6H3,(H,26,27,28)	WCSHCCIQCVRPAY-UHFFFAOYSA-N	247483	US9688672, Example 6::US9434719, 6::US10112931, Example 6	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1270					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247483&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414874	346542023							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564487	COc1cc(ccc1Cl)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)OC(C)(C)C |r|	InChI=1S/C24H29ClN6O5/c1-13(21-29-20(30-36-21)15-7-8-16(25)18(11-15)33-6)27-22-26-10-9-19(28-22)31-17(12-34-23(31)32)14(2)35-24(3,4)5/h7-11,13-14,17H,12H2,1-6H3,(H,26,27,28)	WCSHCCIQCVRPAY-UHFFFAOYSA-N	247483	US9688672, Example 6::US9434719, 6::US10112931, Example 6	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1185					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247483&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414874	346542023							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564488	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)c(OC(F)(F)F)c2)n1 |r|	InChI=1S/C24H26ClF3N6O5/c1-12(20-32-19(33-39-20)14-6-7-15(25)17(10-14)38-24(26,27)28)30-21-29-9-8-18(31-21)34-16(11-36-22(34)35)13(2)37-23(3,4)5/h6-10,12-13,16H,11H2,1-5H3,(H,29,30,31)	RHYKSEFOCABYGI-UHFFFAOYSA-N	247484	US9688672, Example 7::US9434719, 7::US10112931, Example 7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2950					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247484&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414976	346542024							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564489	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)c(OC(F)(F)F)c2)n1 |r|	InChI=1S/C24H26ClF3N6O5/c1-12(20-32-19(33-39-20)14-6-7-15(25)17(10-14)38-24(26,27)28)30-21-29-9-8-18(31-21)34-16(11-36-22(34)35)13(2)37-23(3,4)5/h6-10,12-13,16H,11H2,1-5H3,(H,29,30,31)	RHYKSEFOCABYGI-UHFFFAOYSA-N	247484	US9688672, Example 7::US9434719, 7::US10112931, Example 7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1609					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247484&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414976	346542024							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564490	CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)OC(C)(C)C)c1nc(no1)-c1ccc2ccn(C)c2c1 |r|	InChI=1S/C26H31N7O4/c1-15(23-30-22(31-37-23)18-8-7-17-10-12-32(6)19(17)13-18)28-24-27-11-9-21(29-24)33-20(14-35-25(33)34)16(2)36-26(3,4)5/h7-13,15-16,20H,14H2,1-6H3,(H,27,28,29)	WBIDDDOZQAHNSX-UHFFFAOYSA-N	247485	US9688672, Example 8::US9434719, 8::US10112931, Example 8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2040					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247485&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90413782	346542025							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564491	CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)OC(C)(C)C)c1nc(no1)-c1ccc2ccn(C)c2c1 |r|	InChI=1S/C26H31N7O4/c1-15(23-30-22(31-37-23)18-8-7-17-10-12-32(6)19(17)13-18)28-24-27-11-9-21(29-24)33-20(14-35-25(33)34)16(2)36-26(3,4)5/h7-13,15-16,20H,14H2,1-6H3,(H,27,28,29)	WBIDDDOZQAHNSX-UHFFFAOYSA-N	247485	US9688672, Example 8::US9434719, 8::US10112931, Example 8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 314					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247485&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90413782	346542025							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564492	CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)OC(C)(C)C)c1nc(no1)-c1cccc(c1)C(C)(C)C |r|	InChI=1S/C27H36N6O4/c1-16(23-31-22(32-37-23)18-10-9-11-19(14-18)26(3,4)5)29-24-28-13-12-21(30-24)33-20(15-35-25(33)34)17(2)36-27(6,7)8/h9-14,16-17,20H,15H2,1-8H3,(H,28,29,30)	PSGDZLCFDHDDNW-UHFFFAOYSA-N	247486	US9688672, Example 9::US9434719, 9::US10112931, Example 9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2200					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247486	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247486&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414870	346542026							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564493	CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)OC(C)(C)C)c1nc(no1)-c1cccc(c1)C(C)(C)C |r|	InChI=1S/C27H36N6O4/c1-16(23-31-22(32-37-23)18-10-9-11-19(14-18)26(3,4)5)29-24-28-13-12-21(30-24)33-20(15-35-25(33)34)17(2)36-27(6,7)8/h9-14,16-17,20H,15H2,1-8H3,(H,28,29,30)	PSGDZLCFDHDDNW-UHFFFAOYSA-N	247486	US9688672, Example 9::US9434719, 9::US10112931, Example 9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3019					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247486	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247486&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414870	346542026							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564494	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(OC(F)(F)F)c2)n1 |r|	InChI=1S/C24H27F3N6O5/c1-13(20-31-19(32-38-20)15-7-6-8-16(11-15)37-24(25,26)27)29-21-28-10-9-18(30-21)33-17(12-35-22(33)34)14(2)36-23(3,4)5/h6-11,13-14,17H,12H2,1-5H3,(H,28,29,30)	RTLZLFVDXRHESM-UHFFFAOYSA-N	247487	US9688672, Example 10::US9434719, 10::US10112931, Example 10	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11700					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247487&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414564	346542027							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564495	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(OC(F)(F)F)c2)n1 |r|	InChI=1S/C24H27F3N6O5/c1-13(20-31-19(32-38-20)15-7-6-8-16(11-15)37-24(25,26)27)29-21-28-10-9-18(30-21)33-17(12-35-22(33)34)14(2)36-23(3,4)5/h6-11,13-14,17H,12H2,1-5H3,(H,28,29,30)	RTLZLFVDXRHESM-UHFFFAOYSA-N	247487	US9688672, Example 10::US9434719, 10::US10112931, Example 10	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1710					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247487&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414564	346542027							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564496	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(OC(F)(F)F)c2)n1 |r|	InChI=1S/C24H26F4N6O5/c1-12(20-32-19(33-39-20)14-6-7-15(25)17(10-14)38-24(26,27)28)30-21-29-9-8-18(31-21)34-16(11-36-22(34)35)13(2)37-23(3,4)5/h6-10,12-13,16H,11H2,1-5H3,(H,29,30,31)	OQDLCSKYSGAKQO-UHFFFAOYSA-N	247488	US9688672, Example 11::US9434719, 11::US10112931, Example 11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3050					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247488&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414738	346542028							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564497	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(OC(F)(F)F)c2)n1 |r|	InChI=1S/C24H26F4N6O5/c1-12(20-32-19(33-39-20)14-6-7-15(25)17(10-14)38-24(26,27)28)30-21-29-9-8-18(31-21)34-16(11-36-22(34)35)13(2)37-23(3,4)5/h6-10,12-13,16H,11H2,1-5H3,(H,29,30,31)	OQDLCSKYSGAKQO-UHFFFAOYSA-N	247488	US9688672, Example 11::US9434719, 11::US10112931, Example 11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2453					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247488&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414738	346542028							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564498	CC(C)c1ccc(cc1)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)OC(C)(C)C |r|	InChI=1S/C26H34N6O4/c1-15(2)18-8-10-19(11-9-18)22-30-23(36-31-22)16(3)28-24-27-13-12-21(29-24)32-20(14-34-25(32)33)17(4)35-26(5,6)7/h8-13,15-17,20H,14H2,1-7H3,(H,27,28,29)	YJPDOSRZMMIZGK-UHFFFAOYSA-N	247489	US9688672, Example 12::US9434719, 12::US10112931, Example 12	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3270					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247489&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415538	346542029							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564499	CC(C)c1ccc(cc1)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)OC(C)(C)C |r|	InChI=1S/C26H34N6O4/c1-15(2)18-8-10-19(11-9-18)22-30-23(36-31-22)16(3)28-24-27-13-12-21(29-24)32-20(14-34-25(32)33)17(4)35-26(5,6)7/h8-13,15-17,20H,14H2,1-7H3,(H,27,28,29)	YJPDOSRZMMIZGK-UHFFFAOYSA-N	247489	US9688672, Example 12::US9434719, 12::US10112931, Example 12	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 892					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247489&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415538	346542029							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564500	CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)OC(C)(C)C)c1nc(no1)-c1cccc2n(C)c(C)cc12 |r|	InChI=1S/C27H33N7O4/c1-15-13-19-18(9-8-10-20(19)33(15)7)23-31-24(38-32-23)16(2)29-25-28-12-11-22(30-25)34-21(14-36-26(34)35)17(3)37-27(4,5)6/h8-13,16-17,21H,14H2,1-7H3,(H,28,29,30)	SXVMKUDXOWPKHS-UHFFFAOYSA-N	247490	US9688672, Example 13::US9434719, 13::US10112931, Example 13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2190					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247490&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416719	346542030							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564501	CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)OC(C)(C)C)c1nc(no1)-c1cccc2n(C)c(C)cc12 |r|	InChI=1S/C27H33N7O4/c1-15-13-19-18(9-8-10-20(19)33(15)7)23-31-24(38-32-23)16(2)29-25-28-12-11-22(30-25)34-21(14-36-26(34)35)17(3)37-27(4,5)6/h8-13,16-17,21H,14H2,1-7H3,(H,28,29,30)	SXVMKUDXOWPKHS-UHFFFAOYSA-N	247490	US9688672, Example 13::US9434719, 13::US10112931, Example 13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>5000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247490&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416719	346542030							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564502	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(C)c(o2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C25H30ClN5O4/c1-14-21(17-7-9-18(26)10-8-17)34-22(28-14)15(2)29-23-27-12-11-20(30-23)31-19(13-33-24(31)32)16(3)35-25(4,5)6/h7-12,15-16,19H,13H2,1-6H3,(H,27,29,30)	ARZVPTRNEBWSAE-UHFFFAOYSA-N	247491	US9688672, Example 14::US9434719, 14::US10112931, Example 14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 405					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247491	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247491&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414415	346542031							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564503	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(C)c(o2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C25H30ClN5O4/c1-14-21(17-7-9-18(26)10-8-17)34-22(28-14)15(2)29-23-27-12-11-20(30-23)31-19(13-33-24(31)32)16(3)35-25(4,5)6/h7-12,15-16,19H,13H2,1-6H3,(H,27,29,30)	ARZVPTRNEBWSAE-UHFFFAOYSA-N	247491	US9688672, Example 14::US9434719, 14::US10112931, Example 14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 813					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247491	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247491&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414415	346542031							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564504	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(c(C)s2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C25H29ClFN5O3S/c1-13(22-30-20(15(3)36-22)16-7-9-17(26)10-8-16)29-23-28-11-18(27)21(31-23)32-19(12-34-24(32)33)14(2)35-25(4,5)6/h7-11,13-14,19H,12H2,1-6H3,(H,28,29,31)	ODSXOIRGKNOKPX-UHFFFAOYSA-N	247492	US9688672, Example 26::US9434719, 26::US10112931, Example 26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3350					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247492&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414757	346542032							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564505	C[C@@H](OC(C)(C)C)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(cs2)-c2ccc(Br)cc2)ncc1F |r|	InChI=1S/C24H27BrFN5O3S/c1-13(21-29-18(12-35-21)15-6-8-16(25)9-7-15)28-22-27-10-17(26)20(30-22)31-19(11-33-23(31)32)14(2)34-24(3,4)5/h6-10,12-14,19H,11H2,1-5H3,(H,27,28,30)	ZQTGWCMOCMIHQG-UHFFFAOYSA-N	247493	US9688672, Example 27::US9434719, 27::US10112931, Example 27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2800					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247493&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416499	346542033							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564506	CC(O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)C2CCN(CC2)c2ccc(Cl)c(OC(F)(F)F)c2)ncc1F |r|	InChI=1S/C23H26ClF4N5O4/c1-12(30-21-29-10-17(25)20(31-21)33-18(13(2)34)11-36-22(33)35)14-5-7-32(8-6-14)15-3-4-16(24)19(9-15)37-23(26,27)28/h3-4,9-10,12-14,18,34H,5-8,11H2,1-2H3,(H,29,30,31)	UWJKLSDVLIZTFE-UHFFFAOYSA-N	247494	US9434719, 28::BDBM295678	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5.00					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247494	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247494&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			131635544	346542034							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564507	CC(O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)C2CCN(CC2)c2ccnc(c2)C(C)(C)C(F)(F)F)ncc1F |r|	InChI=1S/C25H32F4N6O3/c1-14(32-22-31-12-18(26)21(33-22)35-19(15(2)36)13-38-23(35)37)16-6-9-34(10-7-16)17-5-8-30-20(11-17)24(3,4)25(27,28)29/h5,8,11-12,14-16,19,36H,6-7,9-10,13H2,1-4H3,(H,31,32,33)	NKYVOLFSPYUGCF-UHFFFAOYSA-N	247495	US9434719, 29::US10112931, Example 29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 27.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247495&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451867	346542035							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564508	C[C@H](Nc1nccc(n1)N1[C@@H](COC1=O)[C@H](C)C(F)(F)F)c1nc(no1)-c1ccc(Cl)cc1 |r|	InChI=1S/C20H18ClF3N6O3/c1-10(20(22,23)24)14-9-32-19(31)30(14)15-7-8-25-18(27-15)26-11(2)17-28-16(29-33-17)12-3-5-13(21)6-4-12/h3-8,10-11,14H,9H2,1-2H3,(H,25,26,27)	VWTGBFKWGWEASC-UHFFFAOYSA-N	295680	US10112931, Example 30	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1090					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295680	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295680&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137529255	381618643							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564509	C[C@H](Nc1nccc(n1)N1[C@@H](COC1=O)[C@H](C)C(F)(F)F)c1nc(no1)-c1ccc(Cl)cc1 |r|	InChI=1S/C20H18ClF3N6O3/c1-10(20(22,23)24)14-9-32-19(31)30(14)15-7-8-25-18(27-15)26-11(2)17-28-16(29-33-17)12-3-5-13(21)6-4-12/h3-8,10-11,14H,9H2,1-2H3,(H,25,26,27)	VWTGBFKWGWEASC-UHFFFAOYSA-N	295680	US10112931, Example 30	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 472					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295680	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295680&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137529255	381618643							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564510	C[C@H](Nc1nccc(n1)N1[C@H](COC1=O)[C@H](C)C(F)(F)F)c1nc(no1)-c1ccc(Cl)cc1 |r|	InChI=1S/C20H18ClF3N6O3/c1-10(20(22,23)24)14-9-32-19(31)30(14)15-7-8-25-18(27-15)26-11(2)17-28-16(29-33-17)12-3-5-13(21)6-4-12/h3-8,10-11,14H,9H2,1-2H3,(H,25,26,27)	VWTGBFKWGWEASC-UHFFFAOYSA-N	295681	US10112931, Example 31	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 627					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295681	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295681&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137529256	381618644							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564511	C[C@H](Nc1nccc(n1)N1[C@H](COC1=O)[C@H](C)C(F)(F)F)c1nc(no1)-c1ccc(Cl)cc1 |r|	InChI=1S/C20H18ClF3N6O3/c1-10(20(22,23)24)14-9-32-19(31)30(14)15-7-8-25-18(27-15)26-11(2)17-28-16(29-33-17)12-3-5-13(21)6-4-12/h3-8,10-11,14H,9H2,1-2H3,(H,25,26,27)	VWTGBFKWGWEASC-UHFFFAOYSA-N	295681	US10112931, Example 31	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 757					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295681	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295681&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137529256	381618644							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564512	C[C@H](Nc1nccc(n1)N1C(COC1=O)C(C)C(F)(F)F)c1nc(no1)-c1ccc(Cl)cc1 |r|	InChI=1S/C20H18ClF3N6O3/c1-10(20(22,23)24)14-9-32-19(31)30(14)15-7-8-25-18(27-15)26-11(2)17-28-16(29-33-17)12-3-5-13(21)6-4-12/h3-8,10-11,14H,9H2,1-2H3,(H,25,26,27)	VWTGBFKWGWEASC-UHFFFAOYSA-N	247496	US9688672, Example 33::US9434719, 32::US9434719, 31::US9434719, 30::US9434719, 33::US10112931, Example 32	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 16.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247496	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247496&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90417333	346542036							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564513	C[C@H](Nc1nccc(n1)N1C(COC1=O)C(C)C(F)(F)F)c1nc(no1)-c1ccc(Cl)cc1 |r|	InChI=1S/C20H18ClF3N6O3/c1-10(20(22,23)24)14-9-32-19(31)30(14)15-7-8-25-18(27-15)26-11(2)17-28-16(29-33-17)12-3-5-13(21)6-4-12/h3-8,10-11,14H,9H2,1-2H3,(H,25,26,27)	VWTGBFKWGWEASC-UHFFFAOYSA-N	247496	US9688672, Example 33::US9434719, 32::US9434719, 31::US9434719, 30::US9434719, 33::US10112931, Example 32	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10.00					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247496	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247496&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90417333	346542036							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564514	C[C@H](Nc1nccc(n1)N1C(COC1=O)[C@@H](C)C(F)(F)F)c1nc(no1)-c1ccc(Cl)cc1 |r|	InChI=1S/C20H18ClF3N6O3/c1-10(20(22,23)24)14-9-32-19(31)30(14)15-7-8-25-18(27-15)26-11(2)17-28-16(29-33-17)12-3-5-13(21)6-4-12/h3-8,10-11,14H,9H2,1-2H3,(H,25,26,27)	VWTGBFKWGWEASC-UHFFFAOYSA-N	295683	US10112931, Example 33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3660					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295683&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137529257	381618646							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564515	C[C@H](Nc1nccc(n1)N1C(COC1=O)[C@@H](C)C(F)(F)F)c1nc(no1)-c1ccc(Cl)cc1 |r|	InChI=1S/C20H18ClF3N6O3/c1-10(20(22,23)24)14-9-32-19(31)30(14)15-7-8-25-18(27-15)26-11(2)17-28-16(29-33-17)12-3-5-13(21)6-4-12/h3-8,10-11,14H,9H2,1-2H3,(H,25,26,27)	VWTGBFKWGWEASC-UHFFFAOYSA-N	295683	US10112931, Example 33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2085					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=295683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=295683&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137529257	381618646							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564516	C[C@H](Nc1ncc(F)c(n1)N1C(COC1=O)C(C)C(F)(F)F)c1ccc(CO)c(F)c1 |r|	InChI=1S/C19H19F5N4O3/c1-9(19(22,23)24)15-8-31-18(30)28(15)16-14(21)6-25-17(27-16)26-10(2)11-3-4-12(7-29)13(20)5-11/h3-6,9-10,15,29H,7-8H2,1-2H3,(H,25,26,27)	KTKQDRRLZACGRQ-UHFFFAOYSA-N	247497	US9688672, Example 34::US9434719, 34::US10112931, Example 34	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 889					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247497	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247497&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415887	346542037							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564517	C[C@H](Nc1ncc(F)c(n1)N1C(COC1=O)C(C)C(F)(F)F)c1ccc(CO)c(F)c1 |r|	InChI=1S/C19H19F5N4O3/c1-9(19(22,23)24)15-8-31-18(30)28(15)16-14(21)6-25-17(27-16)26-10(2)11-3-4-12(7-29)13(20)5-11/h3-6,9-10,15,29H,7-8H2,1-2H3,(H,25,26,27)	KTKQDRRLZACGRQ-UHFFFAOYSA-N	247497	US9688672, Example 34::US9434719, 34::US10112931, Example 34	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 590					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247497	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247497&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415887	346542037							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564518	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cccc(Cl)c2Cl)n1 |r|	InChI=1S/C21H20Cl2N6O3/c1-11(19-25-8-13(9-26-19)14-4-3-5-15(22)18(14)23)27-20-24-7-6-17(28-20)29-16(12(2)30)10-32-21(29)31/h3-9,11-12,16,30H,10H2,1-2H3,(H,24,27,28)	VNCQUMNGFZCPNY-UHFFFAOYSA-N	247498	US9688672, Example 35::US9434719, 35::US10112931, Example 35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 33.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247498	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247498&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416870	346542038							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564519	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cccc(Cl)c2Cl)n1 |r|	InChI=1S/C21H20Cl2N6O3/c1-11(19-25-8-13(9-26-19)14-4-3-5-15(22)18(14)23)27-20-24-7-6-17(28-20)29-16(12(2)30)10-32-21(29)31/h3-9,11-12,16,30H,10H2,1-2H3,(H,24,27,28)	VNCQUMNGFZCPNY-UHFFFAOYSA-N	247498	US9688672, Example 35::US9434719, 35::US10112931, Example 35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 55.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247498	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247498&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416870	346542038							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564520	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccccc2)n1 |r|	InChI=1S/C17H20N4O3/c1-11(13-6-4-3-5-7-13)19-16-18-9-8-15(20-16)21-14(12(2)22)10-24-17(21)23/h3-9,11-12,14,22H,10H2,1-2H3,(H,18,19,20)	KYSQKNCHILVPJH-UHFFFAOYSA-N	247499	US9688672, Example 36::US9434719, 36::US10112931, Example 36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1410					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247499	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247499&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414391	346542039							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564521	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccccc2)n1 |r|	InChI=1S/C17H20N4O3/c1-11(13-6-4-3-5-7-13)19-16-18-9-8-15(20-16)21-14(12(2)22)10-24-17(21)23/h3-9,11-12,14,22H,10H2,1-2H3,(H,18,19,20)	KYSQKNCHILVPJH-UHFFFAOYSA-N	247499	US9688672, Example 36::US9434719, 36::US10112931, Example 36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3497					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247499	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247499&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414391	346542039							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564522	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(OC(F)(F)F)c(Cl)c2)n1 |r|	InChI=1S/C20H18ClF3N6O5/c1-9(26-18-25-6-5-15(27-18)30-13(10(2)31)8-33-19(30)32)17-28-16(29-35-17)11-3-4-14(12(21)7-11)34-20(22,23)24/h3-7,9-10,13,31H,8H2,1-2H3,(H,25,26,27)	CHAWXCNNQSNUNC-UHFFFAOYSA-N	247500	US9688672, Example 38::US9434719, 37::US9434719, 38::US10112931, Example 38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2690					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247500	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247500&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451868	346542040							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564523	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(OC(F)(F)F)c(Cl)c2)n1 |r|	InChI=1S/C20H18ClF3N6O5/c1-9(26-18-25-6-5-15(27-18)30-13(10(2)31)8-33-19(30)32)17-28-16(29-35-17)11-3-4-14(12(21)7-11)34-20(22,23)24/h3-7,9-10,13,31H,8H2,1-2H3,(H,25,26,27)	CHAWXCNNQSNUNC-UHFFFAOYSA-N	247500	US9688672, Example 38::US9434719, 37::US9434719, 38::US10112931, Example 38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3745					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247500	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247500&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451868	346542040							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564524	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(OC(F)(F)F)c(Cl)c2)n1 |r|	InChI=1S/C20H18ClF3N6O5/c1-9(26-18-25-6-5-15(27-18)30-13(10(2)31)8-33-19(30)32)17-28-16(29-35-17)11-3-4-14(12(21)7-11)34-20(22,23)24/h3-7,9-10,13,31H,8H2,1-2H3,(H,25,26,27)	CHAWXCNNQSNUNC-UHFFFAOYSA-N	247500	US9688672, Example 38::US9434719, 37::US9434719, 38::US10112931, Example 38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 55.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247500	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247500&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451868	346542040							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564525	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(OC(F)(F)F)c(Cl)c2)n1 |r|	InChI=1S/C20H18ClF3N6O5/c1-9(26-18-25-6-5-15(27-18)30-13(10(2)31)8-33-19(30)32)17-28-16(29-35-17)11-3-4-14(12(21)7-11)34-20(22,23)24/h3-7,9-10,13,31H,8H2,1-2H3,(H,25,26,27)	CHAWXCNNQSNUNC-UHFFFAOYSA-N	247500	US9688672, Example 38::US9434719, 37::US9434719, 38::US10112931, Example 38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 56.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247500	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247500&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451868	346542040							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564526	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cc(F)ccc2C)n1 |r|	InChI=1S/C22H23FN6O3/c1-12-4-5-16(23)8-17(12)15-9-25-20(26-10-15)13(2)27-21-24-7-6-19(28-21)29-18(14(3)30)11-32-22(29)31/h4-10,13-14,18,30H,11H2,1-3H3,(H,24,27,28)	DBKNSMNYFOEUNI-UHFFFAOYSA-N	247501	US9688672, Example 39::US9434719, 39::US10112931, Example 39	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 202					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247501&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451869	346542041							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564527	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cc(F)ccc2C)n1 |r|	InChI=1S/C22H23FN6O3/c1-12-4-5-16(23)8-17(12)15-9-25-20(26-10-15)13(2)27-21-24-7-6-19(28-21)29-18(14(3)30)11-32-22(29)31/h4-10,13-14,18,30H,11H2,1-3H3,(H,24,27,28)	DBKNSMNYFOEUNI-UHFFFAOYSA-N	247501	US9688672, Example 39::US9434719, 39::US10112931, Example 39	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 211					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247501&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451869	346542041							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564528	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(cc2)C(F)(F)F)n1 |r|	InChI=1S/C22H21F3N6O3/c1-12(19-27-9-15(10-28-19)14-3-5-16(6-4-14)22(23,24)25)29-20-26-8-7-18(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,26,29,30)	CQYRFBORTMYXMZ-UHFFFAOYSA-N	247502	US9688672, Example 40::US9434719, 40::US10112931, Example 40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 175					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247502	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247502&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451875	346542042							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564529	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(cc2)C(F)(F)F)n1 |r|	InChI=1S/C22H21F3N6O3/c1-12(19-27-9-15(10-28-19)14-3-5-16(6-4-14)22(23,24)25)29-20-26-8-7-18(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,26,29,30)	CQYRFBORTMYXMZ-UHFFFAOYSA-N	247502	US9688672, Example 40::US9434719, 40::US10112931, Example 40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 370					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247502	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247502&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451875	346542042							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564530	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(F)c(C)c2)n1 |r|	InChI=1S/C22H23FN6O3/c1-12-8-15(4-5-17(12)23)16-9-25-20(26-10-16)13(2)27-21-24-7-6-19(28-21)29-18(14(3)30)11-32-22(29)31/h4-10,13-14,18,30H,11H2,1-3H3,(H,24,27,28)	NSXQQANUCWJPOY-UHFFFAOYSA-N	247503	US9688672, Example 41::US9434719, 41::US10112931, Example 41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 253					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247503&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451876	346542043							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564531	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(F)c(C)c2)n1 |r|	InChI=1S/C22H23FN6O3/c1-12-8-15(4-5-17(12)23)16-9-25-20(26-10-16)13(2)27-21-24-7-6-19(28-21)29-18(14(3)30)11-32-22(29)31/h4-10,13-14,18,30H,11H2,1-3H3,(H,24,27,28)	NSXQQANUCWJPOY-UHFFFAOYSA-N	247503	US9688672, Example 41::US9434719, 41::US10112931, Example 41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 179					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247503&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451876	346542043							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564532	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)C(C)(C)C)n1 |r|	InChI=1S/C19H26N6O3/c1-11(16-21-8-13(9-22-16)19(3,4)5)23-17-20-7-6-15(24-17)25-14(12(2)26)10-28-18(25)27/h6-9,11-12,14,26H,10H2,1-5H3,(H,20,23,24)	MQJZMGFPYLQLOL-UHFFFAOYSA-N	247504	US9688672, Example 42::US9434719, 42::US10112931, Example 42	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247504&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451870	346542044							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564533	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)C(C)(C)C)n1 |r|	InChI=1S/C19H26N6O3/c1-11(16-21-8-13(9-22-16)19(3,4)5)23-17-20-7-6-15(24-17)25-14(12(2)26)10-28-18(25)27/h6-9,11-12,14,26H,10H2,1-5H3,(H,20,23,24)	MQJZMGFPYLQLOL-UHFFFAOYSA-N	247504	US9688672, Example 42::US9434719, 42::US10112931, Example 42	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1557					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247504&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451870	346542044							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564534	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cccc(c2)C(F)(F)F)n1 |r|	InChI=1S/C22H21F3N6O3/c1-12(19-27-9-15(10-28-19)14-4-3-5-16(8-14)22(23,24)25)29-20-26-7-6-18(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,26,29,30)	VTTHQMCVZHLBRX-UHFFFAOYSA-N	247505	US9434719, 43::US10112931, Example 43	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 45.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247505	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247505&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451872	346542045							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564535	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(Oc3ccccc3)cc2)n1 |r|	InChI=1S/C23H24N4O4/c1-15(17-8-10-19(11-9-17)31-18-6-4-3-5-7-18)25-22-24-13-12-21(26-22)27-20(16(2)28)14-30-23(27)29/h3-13,15-16,20,28H,14H2,1-2H3,(H,24,25,26)	ZVBJTYDCCGJGBT-UHFFFAOYSA-N	247506	US9688672, Example 44::US9434719, 44::US10112931, Example 44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247506	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247506&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451877	346542046							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564536	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(Oc3ccccc3)cc2)n1 |r|	InChI=1S/C23H24N4O4/c1-15(17-8-10-19(11-9-17)31-18-6-4-3-5-7-18)25-22-24-13-12-21(26-22)27-20(16(2)28)14-30-23(27)29/h3-13,15-16,20,28H,14H2,1-2H3,(H,24,25,26)	ZVBJTYDCCGJGBT-UHFFFAOYSA-N	247506	US9688672, Example 44::US9434719, 44::US10112931, Example 44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 33.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247506	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247506&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451877	346542046							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564537	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(Oc3ccc(F)cc3)cn2)n1 |r|	InChI=1S/C21H21FN6O4/c1-12(19-24-9-16(10-25-19)32-15-5-3-14(22)4-6-15)26-20-23-8-7-18(27-20)28-17(13(2)29)11-31-21(28)30/h3-10,12-13,17,29H,11H2,1-2H3,(H,23,26,27)	WRLFEODZWQFNLL-UHFFFAOYSA-N	247507	US9688672, Example 45::US9434719, 45::US10112931, Example 45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1000					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247507	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247507&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451871	346542047							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564538	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(Oc3ccc(F)cc3)cn2)n1 |r|	InChI=1S/C21H21FN6O4/c1-12(19-24-9-16(10-25-19)32-15-5-3-14(22)4-6-15)26-20-23-8-7-18(27-20)28-17(13(2)29)11-31-21(28)30/h3-10,12-13,17,29H,11H2,1-2H3,(H,23,26,27)	WRLFEODZWQFNLL-UHFFFAOYSA-N	247507	US9688672, Example 45::US9434719, 45::US10112931, Example 45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1237					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247507	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247507&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451871	346542047							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564539	C[C@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C19H19ClN6O4/c1-10(17-24-16(25-30-17)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	HUKBLSVUBDBPMC-UHFFFAOYSA-N	247508	US9688672, Example 46::US9434719, 46::US10112931, Example 46	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2530					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247508	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247508&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451881	346542048							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564540	C[C@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C19H19ClN6O4/c1-10(17-24-16(25-30-17)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	HUKBLSVUBDBPMC-UHFFFAOYSA-N	247508	US9688672, Example 46::US9434719, 46::US10112931, Example 46	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1930					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247508	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247508&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451881	346542048							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564541	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(cn2)-c2cccc(c2)C(F)(F)F)n1 |r|	InChI=1S/C22H21F3N6O3/c1-12(16-9-28-17(10-27-16)14-4-3-5-15(8-14)22(23,24)25)29-20-26-7-6-19(30-20)31-18(13(2)32)11-34-21(31)33/h3-10,12-13,18,32H,11H2,1-2H3,(H,26,29,30)	AIHAGIQAZSVDEI-UHFFFAOYSA-N	247509	US9688672, Example 47::US9434719, 47::US10112931, Example 47	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 33.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247509&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268194	346542049							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564542	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(cn2)-c2cccc(c2)C(F)(F)F)n1 |r|	InChI=1S/C22H21F3N6O3/c1-12(16-9-28-17(10-27-16)14-4-3-5-15(8-14)22(23,24)25)29-20-26-7-6-19(30-20)31-18(13(2)32)11-34-21(31)33/h3-10,12-13,18,32H,11H2,1-2H3,(H,26,29,30)	AIHAGIQAZSVDEI-UHFFFAOYSA-N	247509	US9688672, Example 47::US9434719, 47::US10112931, Example 47	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 36.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247509&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268194	346542049							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564543	CC(O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(CN3CCN(C)C(C)(C)C3)c(F)c2)n1 |r|	InChI=1S/C25H35FN6O3/c1-16(28-23-27-9-8-22(29-23)32-21(17(2)33)14-35-24(32)34)18-6-7-19(20(26)12-18)13-31-11-10-30(5)25(3,4)15-31/h6-9,12,16-17,21,33H,10-11,13-15H2,1-5H3,(H,27,28,29)	BUVUVNWDUKCPLA-UHFFFAOYSA-N	247510	US9688672, Example 48::US9434719, 48::US10112931, Example 48	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 463					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247510&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451873	346542050							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564544	CC(O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(CN3CCN(C)C(C)(C)C3)c(F)c2)n1 |r|	InChI=1S/C25H35FN6O3/c1-16(28-23-27-9-8-22(29-23)32-21(17(2)33)14-35-24(32)34)18-6-7-19(20(26)12-18)13-31-11-10-30(5)25(3,4)15-31/h6-9,12,16-17,21,33H,10-11,13-15H2,1-5H3,(H,27,28,29)	BUVUVNWDUKCPLA-UHFFFAOYSA-N	247510	US9688672, Example 48::US9434719, 48::US10112931, Example 48	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 775					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247510&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451873	346542050							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564545	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(CN3CCC(F)(F)CC3)c(F)c2)n1 |r|	InChI=1S/C23H28F3N5O3/c1-14(16-3-4-17(18(24)11-16)12-30-9-6-23(25,26)7-10-30)28-21-27-8-5-20(29-21)31-19(15(2)32)13-34-22(31)33/h3-5,8,11,14-15,19,32H,6-7,9-10,12-13H2,1-2H3,(H,27,28,29)	LVDUCEDNLXIWLY-UHFFFAOYSA-N	247511	US9434719, 49::US10112931, Example 49	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 94.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247511	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247511&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451878	346542051							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564546	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2ccc(F)c(C)c2)n1 |r|	InChI=1S/C23H24FN5O3/c1-13-10-16(4-6-18(13)24)17-5-7-19(26-11-17)14(2)27-22-25-9-8-21(28-22)29-20(15(3)30)12-32-23(29)31/h4-11,14-15,20,30H,12H2,1-3H3,(H,25,27,28)	XSHFXIHZJXTBDV-UHFFFAOYSA-N	247512	US9688672, Example 50::US9434719, 50::US10112931, Example 50	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 37.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247512&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268195	346542052							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564547	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2ccc(F)c(C)c2)n1 |r|	InChI=1S/C23H24FN5O3/c1-13-10-16(4-6-18(13)24)17-5-7-19(26-11-17)14(2)27-22-25-9-8-21(28-22)29-20(15(3)30)12-32-23(29)31/h4-11,14-15,20,30H,12H2,1-3H3,(H,25,27,28)	XSHFXIHZJXTBDV-UHFFFAOYSA-N	247512	US9688672, Example 50::US9434719, 50::US10112931, Example 50	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 43.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247512&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268195	346542052							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564548	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2cccc(c2)C(F)(F)F)n1 |r|	InChI=1S/C23H22F3N5O3/c1-13(18-7-6-16(11-28-18)15-4-3-5-17(10-15)23(24,25)26)29-21-27-9-8-20(30-21)31-19(14(2)32)12-34-22(31)33/h3-11,13-14,19,32H,12H2,1-2H3,(H,27,29,30)	VMDPHSXVIWXENL-UHFFFAOYSA-N	247513	US9688672, Example 51::US9434719, 51::US10112931, Example 51	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 13.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247513&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268196	346542053							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564549	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2cccc(c2)C(F)(F)F)n1 |r|	InChI=1S/C23H22F3N5O3/c1-13(18-7-6-16(11-28-18)15-4-3-5-17(10-15)23(24,25)26)29-21-27-9-8-20(30-21)31-19(14(2)32)12-34-22(31)33/h3-11,13-14,19,32H,12H2,1-2H3,(H,27,29,30)	VMDPHSXVIWXENL-UHFFFAOYSA-N	247513	US9688672, Example 51::US9434719, 51::US10112931, Example 51	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 16.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247513&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268196	346542053							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564550	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(nc2)-c2ccc(F)c(C)c2)n1 |r|	InChI=1S/C23H24FN5O3/c1-13-10-16(4-6-18(13)24)19-7-5-17(11-26-19)14(2)27-22-25-9-8-21(28-22)29-20(15(3)30)12-32-23(29)31/h4-11,14-15,20,30H,12H2,1-3H3,(H,25,27,28)	GURKVSMLMZITAJ-UHFFFAOYSA-N	247514	US9688672, Example 52::US9434719, 52::US10112931, Example 52	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 131					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247514&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451884	346542054							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564551	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(nc2)-c2ccc(F)c(C)c2)n1 |r|	InChI=1S/C23H24FN5O3/c1-13-10-16(4-6-18(13)24)19-7-5-17(11-26-19)14(2)27-22-25-9-8-21(28-22)29-20(15(3)30)12-32-23(29)31/h4-11,14-15,20,30H,12H2,1-3H3,(H,25,27,28)	GURKVSMLMZITAJ-UHFFFAOYSA-N	247514	US9688672, Example 52::US9434719, 52::US10112931, Example 52	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 194					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247514&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451884	346542054							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564552	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(nc2)-c2cccc(c2)C(F)(F)F)n1 |r|	InChI=1S/C23H22F3N5O3/c1-13(16-6-7-18(28-11-16)15-4-3-5-17(10-15)23(24,25)26)29-21-27-9-8-20(30-21)31-19(14(2)32)12-34-22(31)33/h3-11,13-14,19,32H,12H2,1-2H3,(H,27,29,30)	BKVBSKXUIQWZHL-UHFFFAOYSA-N	247515	US9688672, Example 53::US9434719, 53::US10112931, Example 53	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 42.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247515&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451890	346542055							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564553	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(nc2)-c2cccc(c2)C(F)(F)F)n1 |r|	InChI=1S/C23H22F3N5O3/c1-13(16-6-7-18(28-11-16)15-4-3-5-17(10-15)23(24,25)26)29-21-27-9-8-20(30-21)31-19(14(2)32)12-34-22(31)33/h3-11,13-14,19,32H,12H2,1-2H3,(H,27,29,30)	BKVBSKXUIQWZHL-UHFFFAOYSA-N	247515	US9688672, Example 53::US9434719, 53::US10112931, Example 53	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 59.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247515&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451890	346542055							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564554	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(cn2)-c2ccc(F)c(C)c2)n1 |r|	InChI=1S/C22H23FN6O3/c1-12-8-15(4-5-16(12)23)18-10-25-17(9-26-18)13(2)27-21-24-7-6-20(28-21)29-19(14(3)30)11-32-22(29)31/h4-10,13-14,19,30H,11H2,1-3H3,(H,24,27,28)	HPYOOSCRXHFCAE-UHFFFAOYSA-N	247516	US9688672, Example 54::US9434719, 54::US10112931, Example 54	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 116					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247516&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451893	346542056							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564555	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(cn2)-c2ccc(F)c(C)c2)n1 |r|	InChI=1S/C22H23FN6O3/c1-12-8-15(4-5-16(12)23)18-10-25-17(9-26-18)13(2)27-21-24-7-6-20(28-21)29-19(14(3)30)11-32-22(29)31/h4-10,13-14,19,30H,11H2,1-3H3,(H,24,27,28)	HPYOOSCRXHFCAE-UHFFFAOYSA-N	247516	US9688672, Example 54::US9434719, 54::US10112931, Example 54	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 119					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247516&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451893	346542056							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564556	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C22H21F3N6O3/c1-12(16-4-3-15(10-28-16)14-5-7-26-18(9-14)22(23,24)25)29-20-27-8-6-19(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,27,29,30)	RAPXSRRDJSAQDZ-UHFFFAOYSA-N	247517	US9688672, Example 55::US9434719, 55::US10112931, Example 55	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 267					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247517&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451880	346542057							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564557	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C22H21F3N6O3/c1-12(16-4-3-15(10-28-16)14-5-7-26-18(9-14)22(23,24)25)29-20-27-8-6-19(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,27,29,30)	RAPXSRRDJSAQDZ-UHFFFAOYSA-N	247517	US9688672, Example 55::US9434719, 55::US10112931, Example 55	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 323					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247517&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451880	346542057							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564558	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(nc2)-c2ccc(nc2)C(F)(F)F)n1 |r|	InChI=1S/C22H21F3N6O3/c1-12(14-3-5-16(27-9-14)15-4-6-18(28-10-15)22(23,24)25)29-20-26-8-7-19(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,26,29,30)	XFSCNSBPYIWAHD-UHFFFAOYSA-N	247518	US9688672, Example 56::US9434719, 56::US10112931, Example 56	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2920					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247518&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451887	346542058							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564559	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(nc2)-c2ccc(nc2)C(F)(F)F)n1 |r|	InChI=1S/C22H21F3N6O3/c1-12(14-3-5-16(27-9-14)15-4-6-18(28-10-15)22(23,24)25)29-20-26-8-7-19(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,26,29,30)	XFSCNSBPYIWAHD-UHFFFAOYSA-N	247518	US9688672, Example 56::US9434719, 56::US10112931, Example 56	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1549					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247518&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451887	346542058							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564560	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2ccc(nc2)C(F)(F)F)n1 |r|	InChI=1S/C22H21F3N6O3/c1-12(16-5-3-14(9-27-16)15-4-6-18(28-10-15)22(23,24)25)29-20-26-8-7-19(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,26,29,30)	XTXYFSXXMOXDER-UHFFFAOYSA-N	247519	US9688672, Example 57::US9434719, 57::US10112931, Example 57	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1270					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247519&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451894	346542059							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564561	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2ccc(nc2)C(F)(F)F)n1 |r|	InChI=1S/C22H21F3N6O3/c1-12(16-5-3-14(9-27-16)15-4-6-18(28-10-15)22(23,24)25)29-20-26-8-7-19(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,26,29,30)	XTXYFSXXMOXDER-UHFFFAOYSA-N	247519	US9688672, Example 57::US9434719, 57::US10112931, Example 57	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1131					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247519&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451894	346542059							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564562	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2cccc(n2)C(F)(F)F)n1 |r|	InChI=1S/C22H21F3N6O3/c1-12(15-7-6-14(10-27-15)16-4-3-5-18(29-16)22(23,24)25)28-20-26-9-8-19(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,26,28,30)	IUXAIJRAELDFJN-UHFFFAOYSA-N	247520	US9688672, Example 58::US9434719, 58::US10112931, Example 58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 27.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247520&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268388	346542060							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564563	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2cccc(n2)C(F)(F)F)n1 |r|	InChI=1S/C22H21F3N6O3/c1-12(15-7-6-14(10-27-15)16-4-3-5-18(29-16)22(23,24)25)28-20-26-9-8-19(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,26,28,30)	IUXAIJRAELDFJN-UHFFFAOYSA-N	247520	US9688672, Example 58::US9434719, 58::US10112931, Example 58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247520&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268388	346542060							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564564	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(C)c(cn2)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C23H23F3N6O3/c1-12-8-17(29-10-16(12)15-4-6-27-19(9-15)23(24,25)26)13(2)30-21-28-7-5-20(31-21)32-18(14(3)33)11-35-22(32)34/h4-10,13-14,18,33H,11H2,1-3H3,(H,28,30,31)	ABQRTQHBTVLJNQ-UHFFFAOYSA-N	247521	US9688672, Example 59::US9434719, 59::US10112931, Example 59	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 79.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247521&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268389	346542061							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564565	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(C)c(cn2)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C23H23F3N6O3/c1-12-8-17(29-10-16(12)15-4-6-27-19(9-15)23(24,25)26)13(2)30-21-28-7-5-20(31-21)32-18(14(3)33)11-35-22(32)34/h4-10,13-14,18,33H,11H2,1-3H3,(H,28,30,31)	ABQRTQHBTVLJNQ-UHFFFAOYSA-N	247521	US9688672, Example 59::US9434719, 59::US10112931, Example 59	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 33.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247521&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268389	346542061							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564566	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cc2F)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C22H20F4N6O3/c1-11(30-20-28-6-4-18(31-20)32-16(12(2)33)10-35-21(32)34)19-15(23)7-14(9-29-19)13-3-5-27-17(8-13)22(24,25)26/h3-9,11-12,16,33H,10H2,1-2H3,(H,28,30,31)	SYJIJRYLJLWTSU-UHFFFAOYSA-N	247522	US9688672, Example 60::US9434719, 60::US10112931, Example 60	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1100					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247522&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451888	346542062							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564567	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cc2F)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C22H20F4N6O3/c1-11(30-20-28-6-4-18(31-20)32-16(12(2)33)10-35-21(32)34)19-15(23)7-14(9-29-19)13-3-5-27-17(8-13)22(24,25)26/h3-9,11-12,16,33H,10H2,1-2H3,(H,28,30,31)	SYJIJRYLJLWTSU-UHFFFAOYSA-N	247522	US9688672, Example 60::US9434719, 60::US10112931, Example 60	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 201					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247522&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451888	346542062							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564568	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cc2C)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C23H23F3N6O3/c1-12-8-16(15-4-6-27-18(9-15)23(24,25)26)10-29-20(12)13(2)30-21-28-7-5-19(31-21)32-17(14(3)33)11-35-22(32)34/h4-10,13-14,17,33H,11H2,1-3H3,(H,28,30,31)	SVDPLBBUVZHJFA-UHFFFAOYSA-N	247523	US9688672, Example 61::US9434719, 61::US10112931, Example 61	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 313					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247523	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247523&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451882	346542063							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564569	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cc2C)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C23H23F3N6O3/c1-12-8-16(15-4-6-27-18(9-15)23(24,25)26)10-29-20(12)13(2)30-21-28-7-5-19(31-21)32-17(14(3)33)11-35-22(32)34/h4-10,13-14,17,33H,11H2,1-3H3,(H,28,30,31)	SVDPLBBUVZHJFA-UHFFFAOYSA-N	247523	US9688672, Example 61::US9434719, 61::US10112931, Example 61	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 156					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247523	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247523&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451882	346542063							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564570	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(c(C)n2)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C23H23F3N6O3/c1-12-16(15-6-8-27-19(10-15)23(24,25)26)4-5-17(29-12)13(2)30-21-28-9-7-20(31-21)32-18(14(3)33)11-35-22(32)34/h4-10,13-14,18,33H,11H2,1-3H3,(H,28,30,31)	SDEKOZLCFXOLKN-UHFFFAOYSA-N	247524	US9688672, Example 62::US9434719, 62::US10112931, Example 62	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 530					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247524	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247524&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451883	346542064							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564571	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(c(C)n2)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C23H23F3N6O3/c1-12-16(15-6-8-27-19(10-15)23(24,25)26)4-5-17(29-12)13(2)30-21-28-9-7-20(31-21)32-18(14(3)33)11-35-22(32)34/h4-10,13-14,18,33H,11H2,1-3H3,(H,28,30,31)	SDEKOZLCFXOLKN-UHFFFAOYSA-N	247524	US9688672, Example 62::US9434719, 62::US10112931, Example 62	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 87.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247524	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247524&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451883	346542064							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564572	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2ccnc(c2)C(C)(C)C)n1 |r|	InChI=1S/C25H30N6O3/c1-15(19-7-6-18(13-28-19)17-8-10-26-21(12-17)25(3,4)5)29-23-27-11-9-22(30-23)31-20(16(2)32)14-34-24(31)33/h6-13,15-16,20,32H,14H2,1-5H3,(H,27,29,30)	ALPDIKWODPVZHR-UHFFFAOYSA-N	247525	US9688672, Example 63::US9434719, 63::US10112931, Example 63	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<15.9					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247525&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451885	346542065							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564573	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2ccnc(c2)C(C)(C)C)n1 |r|	InChI=1S/C25H30N6O3/c1-15(19-7-6-18(13-28-19)17-8-10-26-21(12-17)25(3,4)5)29-23-27-11-9-22(30-23)31-20(16(2)32)14-34-24(31)33/h6-13,15-16,20,32H,14H2,1-5H3,(H,27,29,30)	ALPDIKWODPVZHR-UHFFFAOYSA-N	247525	US9688672, Example 63::US9434719, 63::US10112931, Example 63	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5.00					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247525&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451885	346542065							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564574	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2ccnc(c2)C(C)(C)C(F)(F)F)n1 |r|	InChI=1S/C25H27F3N6O3/c1-14(32-22-30-10-8-21(33-22)34-19(15(2)35)13-37-23(34)36)18-6-5-17(12-31-18)16-7-9-29-20(11-16)24(3,4)25(26,27)28/h5-12,14-15,19,35H,13H2,1-4H3,(H,30,32,33)	MUANIOOVSJGJDK-UHFFFAOYSA-N	247526	US9688672, Example 64::US9434719, 64::US10112931, Example 64	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<15.9					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247526&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451896	346542066							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564575	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2ccnc(c2)C(C)(C)C(F)(F)F)n1 |r|	InChI=1S/C25H27F3N6O3/c1-14(32-22-30-10-8-21(33-22)34-19(15(2)35)13-37-23(34)36)18-6-5-17(12-31-18)16-7-9-29-20(11-16)24(3,4)25(26,27)28/h5-12,14-15,19,35H,13H2,1-4H3,(H,30,32,33)	MUANIOOVSJGJDK-UHFFFAOYSA-N	247526	US9688672, Example 64::US9434719, 64::US10112931, Example 64	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 8.00					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247526&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451896	346542066							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564576	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2nc(cs2)-c2ccc(cc2)C#N)n1 |r|	InChI=1S/C21H20N6O3S/c1-12(19-25-16(11-31-19)15-5-3-14(9-22)4-6-15)24-20-23-8-7-18(26-20)27-17(13(2)28)10-30-21(27)29/h3-8,11-13,17,28H,10H2,1-2H3,(H,23,24,26)	XRDCVBTVNWZCPZ-UHFFFAOYSA-N	247527	US9688672, Example 65::US9434719, 65::US10112931, Example 65	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 797					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247527&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451895	346542067							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564577	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2nc(cs2)-c2ccc(cc2)C#N)n1 |r|	InChI=1S/C21H20N6O3S/c1-12(19-25-16(11-31-19)15-5-3-14(9-22)4-6-15)24-20-23-8-7-18(26-20)27-17(13(2)28)10-30-21(27)29/h3-8,11-13,17,28H,10H2,1-2H3,(H,23,24,26)	XRDCVBTVNWZCPZ-UHFFFAOYSA-N	247527	US9688672, Example 65::US9434719, 65::US10112931, Example 65	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 582					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247527&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451895	346542067							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564578	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClN5O4/c1-11(15-9-17(30-25-15)13-3-5-14(21)6-4-13)23-19-22-8-7-18(24-19)26-16(12(2)27)10-29-20(26)28/h3-9,11-12,16,27H,10H2,1-2H3,(H,22,23,24)	QNYFRTGGICDZAT-UHFFFAOYSA-N	247528	US9688672, Example 66::US9434719, 66::US10112931, Example 66	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 61.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247528&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268804	346542068							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564579	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClN5O4/c1-11(15-9-17(30-25-15)13-3-5-14(21)6-4-13)23-19-22-8-7-18(24-19)26-16(12(2)27)10-29-20(26)28/h3-9,11-12,16,27H,10H2,1-2H3,(H,22,23,24)	QNYFRTGGICDZAT-UHFFFAOYSA-N	247528	US9688672, Example 66::US9434719, 66::US10112931, Example 66	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 66.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247528&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268804	346542068							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564580	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@H](C)c2nc(cs2)-c2ccc(Cl)cc2Cl)n1 |r|	InChI=1S/C20H19Cl2N5O3S/c1-10(18-25-15(9-31-18)13-4-3-12(21)7-14(13)22)24-19-23-6-5-17(26-19)27-16(11(2)28)8-30-20(27)29/h3-7,9-11,16,28H,8H2,1-2H3,(H,23,24,26)	XOQPIDDDNUXVGQ-UHFFFAOYSA-N	247529	US9688672, Example 67::US9434719, 67::US10112931, Example 67	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1010					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247529&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451899	346542069							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564581	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@H](C)c2nc(cs2)-c2ccc(Cl)cc2Cl)n1 |r|	InChI=1S/C20H19Cl2N5O3S/c1-10(18-25-15(9-31-18)13-4-3-12(21)7-14(13)22)24-19-23-6-5-17(26-19)27-16(11(2)28)8-30-20(27)29/h3-7,9-11,16,28H,8H2,1-2H3,(H,23,24,26)	XOQPIDDDNUXVGQ-UHFFFAOYSA-N	247529	US9688672, Example 67::US9434719, 67::US10112931, Example 67	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1437					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247529&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451899	346542069							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564582	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2nc(cs2)-c2ccc(Cl)cc2Cl)n1 |r|	InChI=1S/C20H19Cl2N5O3S/c1-10(18-25-15(9-31-18)13-4-3-12(21)7-14(13)22)24-19-23-6-5-17(26-19)27-16(11(2)28)8-30-20(27)29/h3-7,9-11,16,28H,8H2,1-2H3,(H,23,24,26)	XOQPIDDDNUXVGQ-UHFFFAOYSA-N	247530	US9688672, Example 68::US9434719, 68::US10112931, Example 68	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 50.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247530&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451889	346542070							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564583	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2nc(cs2)-c2ccc(Cl)cc2Cl)n1 |r|	InChI=1S/C20H19Cl2N5O3S/c1-10(18-25-15(9-31-18)13-4-3-12(21)7-14(13)22)24-19-23-6-5-17(26-19)27-16(11(2)28)8-30-20(27)29/h3-7,9-11,16,28H,8H2,1-2H3,(H,23,24,26)	XOQPIDDDNUXVGQ-UHFFFAOYSA-N	247530	US9688672, Example 68::US9434719, 68::US10112931, Example 68	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 112					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247530&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451889	346542070							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564584	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@H](C)c2nc(cs2)-c2ccc(Br)cc2)n1 |r|	InChI=1S/C20H20BrN5O3S/c1-11(18-24-15(10-30-18)13-3-5-14(21)6-4-13)23-19-22-8-7-17(25-19)26-16(12(2)27)9-29-20(26)28/h3-8,10-12,16,27H,9H2,1-2H3,(H,22,23,25)	DIUJFHLCTQVPQN-UHFFFAOYSA-N	247531	US9688672, Example 69::US9434719, 69::US10112931, Example 69	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 639					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247531&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451900	346542071							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564585	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@H](C)c2nc(cs2)-c2ccc(Br)cc2)n1 |r|	InChI=1S/C20H20BrN5O3S/c1-11(18-24-15(10-30-18)13-3-5-14(21)6-4-13)23-19-22-8-7-17(25-19)26-16(12(2)27)9-29-20(26)28/h3-8,10-12,16,27H,9H2,1-2H3,(H,22,23,25)	DIUJFHLCTQVPQN-UHFFFAOYSA-N	247531	US9688672, Example 69::US9434719, 69::US10112931, Example 69	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>5000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247531&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451900	346542071							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564586	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2nc(cs2)-c2ccc(Br)cc2)n1 |r|	InChI=1S/C20H20BrN5O3S/c1-11(18-24-15(10-30-18)13-3-5-14(21)6-4-13)23-19-22-8-7-17(25-19)26-16(12(2)27)9-29-20(26)28/h3-8,10-12,16,27H,9H2,1-2H3,(H,22,23,25)	DIUJFHLCTQVPQN-UHFFFAOYSA-N	247532	US9688672, Example 70::US9434719, 70::US10112931, Example 70	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 73.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247532	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247532&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451892	346542072							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564587	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2nc(cs2)-c2ccc(Br)cc2)n1 |r|	InChI=1S/C20H20BrN5O3S/c1-11(18-24-15(10-30-18)13-3-5-14(21)6-4-13)23-19-22-8-7-17(25-19)26-16(12(2)27)9-29-20(26)28/h3-8,10-12,16,27H,9H2,1-2H3,(H,22,23,25)	DIUJFHLCTQVPQN-UHFFFAOYSA-N	247532	US9688672, Example 70::US9434719, 70::US10112931, Example 70	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 80.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247532	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247532&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451892	346542072							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564588	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@H](C)c2nc(cs2)-c2ccc(cc2)C#N)n1 |r|	InChI=1S/C21H20N6O3S/c1-12(19-25-16(11-31-19)15-5-3-14(9-22)4-6-15)24-20-23-8-7-18(26-20)27-17(13(2)28)10-30-21(27)29/h3-8,11-13,17,28H,10H2,1-2H3,(H,23,24,26)	XRDCVBTVNWZCPZ-UHFFFAOYSA-N	247533	US9688672, Example 71::US9434719, 71::US10112931, Example 71	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247533&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451897	346542073							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564589	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@H](C)c2nc(cs2)-c2ccc(cc2)C#N)n1 |r|	InChI=1S/C21H20N6O3S/c1-12(19-25-16(11-31-19)15-5-3-14(9-22)4-6-15)24-20-23-8-7-18(26-20)27-17(13(2)28)10-30-21(27)29/h3-8,11-13,17,28H,10H2,1-2H3,(H,23,24,26)	XRDCVBTVNWZCPZ-UHFFFAOYSA-N	247533	US9688672, Example 71::US9434719, 71::US10112931, Example 71	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>5000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247533&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451897	346542073							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564590	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(CN3CCN(C)CC3)cc2)n1 |r|	InChI=1S/C23H32N6O3/c1-16(19-6-4-18(5-7-19)14-28-12-10-27(3)11-13-28)25-22-24-9-8-21(26-22)29-20(17(2)30)15-32-23(29)31/h4-9,16-17,20,30H,10-15H2,1-3H3,(H,24,25,26)	GNNQUSABQDTPGU-UHFFFAOYSA-N	247534	US9434719, 72::US10112931, Example 72	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12152					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247534&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451907	346542074							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564591	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ccc(c(F)c2)-n2cc(C)cn2)n1 |r|	InChI=1S/C21H23FN6O3/c1-12-9-24-27(10-12)17-5-4-15(8-16(17)22)13(2)25-20-23-7-6-19(26-20)28-18(14(3)29)11-31-21(28)30/h4-10,13-14,18,29H,11H2,1-3H3,(H,23,25,26)	XDTMKVBEWIAKJH-UHFFFAOYSA-N	247535	US9688672, Example 73::US9434719, 73::US10112931, Example 73	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 181					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247535	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247535&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451902	346542075							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564592	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ccc(c(F)c2)-n2cc(C)cn2)n1 |r|	InChI=1S/C21H23FN6O3/c1-12-9-24-27(10-12)17-5-4-15(8-16(17)22)13(2)25-20-23-7-6-19(26-20)28-18(14(3)29)11-31-21(28)30/h4-10,13-14,18,29H,11H2,1-3H3,(H,23,25,26)	XDTMKVBEWIAKJH-UHFFFAOYSA-N	247535	US9688672, Example 73::US9434719, 73::US10112931, Example 73	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 571					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247535	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247535&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451902	346542075							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564593	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2ncc([nH]2)-c2ccc(Cl)c(Cl)c2)ncc1F |r|	InChI=1S/C20H19Cl2FN6O3/c1-9(17-24-7-15(27-17)11-3-4-12(21)13(22)5-11)26-19-25-6-14(23)18(28-19)29-16(10(2)30)8-32-20(29)31/h3-7,9-10,16,30H,8H2,1-2H3,(H,24,27)(H,25,26,28)	BWAIUCHQMVDAJI-UHFFFAOYSA-N	247536	US9434719, 74::US10112931, Example 74	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>5000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247536	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247536&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451908	346542076							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564594	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(CN3CCC(F)(F)CC3)cn2)n1 |r|	InChI=1S/C22H28F2N6O3/c1-14(17-4-3-16(11-26-17)12-29-9-6-22(23,24)7-10-29)27-20-25-8-5-19(28-20)30-18(15(2)31)13-33-21(30)32/h3-5,8,11,14-15,18,31H,6-7,9-10,12-13H2,1-2H3,(H,25,27,28)	WMZLIRFKBWDYTL-UHFFFAOYSA-N	247537	US9434719, 76::US10112931, Example 76	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 546					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247537&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451901	346542077							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564595	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(CN3CCC(F)(F)CC3)nc2)n1 |r|	InChI=1S/C22H28F2N6O3/c1-14(16-3-4-17(26-11-16)12-29-9-6-22(23,24)7-10-29)27-20-25-8-5-19(28-20)30-18(15(2)31)13-33-21(30)32/h3-5,8,11,14-15,18,31H,6-7,9-10,12-13H2,1-2H3,(H,25,27,28)	KVOJTFGPNFHRHP-UHFFFAOYSA-N	247538	US9434719, 77::US10112931, Example 77	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 911					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247538&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118121705	346542078							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564596	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@H](C)c2cnc(cn2)-c2cccc(c2)C(F)(F)F)n1 |r|	InChI=1S/C22H21F3N6O3/c1-12(16-9-28-17(10-27-16)14-4-3-5-15(8-14)22(23,24)25)29-20-26-7-6-19(30-20)31-18(13(2)32)11-34-21(31)33/h3-10,12-13,18,32H,11H2,1-2H3,(H,26,29,30)	AIHAGIQAZSVDEI-UHFFFAOYSA-N	247539	US9688672, Example 78::US9434719, 78::US10112931, Example 78	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1630					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247539	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247539&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451909	346542079							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564597	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@H](C)c2cnc(cn2)-c2cccc(c2)C(F)(F)F)n1 |r|	InChI=1S/C22H21F3N6O3/c1-12(16-9-28-17(10-27-16)14-4-3-5-15(8-14)22(23,24)25)29-20-26-7-6-19(30-20)31-18(13(2)32)11-34-21(31)33/h3-10,12-13,18,32H,11H2,1-2H3,(H,26,29,30)	AIHAGIQAZSVDEI-UHFFFAOYSA-N	247539	US9688672, Example 78::US9434719, 78::US10112931, Example 78	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2560					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247539	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247539&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451909	346542079							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564598	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@H](C)c2cnc(cn2)-c2ccc(F)c(C)c2)n1 |r|	InChI=1S/C22H23FN6O3/c1-12-8-15(4-5-16(12)23)18-10-25-17(9-26-18)13(2)27-21-24-7-6-20(28-21)29-19(14(3)30)11-32-22(29)31/h4-10,13-14,19,30H,11H2,1-3H3,(H,24,27,28)	HPYOOSCRXHFCAE-UHFFFAOYSA-N	247540	US9688672, Example 79::US9434719, 79::US10112931, Example 79	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5310					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247540&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451904	346542080							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564599	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@H](C)c2cnc(cn2)-c2ccc(F)c(C)c2)n1 |r|	InChI=1S/C22H23FN6O3/c1-12-8-15(4-5-16(12)23)18-10-25-17(9-26-18)13(2)27-21-24-7-6-20(28-21)29-19(14(3)30)11-32-22(29)31/h4-10,13-14,19,30H,11H2,1-3H3,(H,24,27,28)	HPYOOSCRXHFCAE-UHFFFAOYSA-N	247540	US9688672, Example 79::US9434719, 79::US10112931, Example 79	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>5000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247540&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451904	346542080							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564600	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(F)c(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C22H20F4N6O3/c1-11(30-20-27-6-5-18(31-20)32-17(12(2)33)10-35-21(32)34)19-28-8-14(9-29-19)13-3-4-16(23)15(7-13)22(24,25)26/h3-9,11-12,17,33H,10H2,1-2H3,(H,27,30,31)	HEWNCZLHQDDEPX-UHFFFAOYSA-N	174779	US9688672, Example 80::US10112931, Example 81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 37.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174779&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451905	363892235							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564601	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(F)c(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C22H20F4N6O3/c1-11(30-20-27-6-5-18(31-20)32-17(12(2)33)10-35-21(32)34)19-28-8-14(9-29-19)13-3-4-16(23)15(7-13)22(24,25)26/h3-9,11-12,17,33H,10H2,1-2H3,(H,27,30,31)	HEWNCZLHQDDEPX-UHFFFAOYSA-N	174779	US9688672, Example 80::US10112931, Example 81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 31.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174779&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451905	363892235							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564602	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(F)c(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C22H20F4N6O3/c1-11(30-20-27-6-5-18(31-20)32-17(12(2)33)10-35-21(32)34)19-28-8-14(9-29-19)13-3-4-16(23)15(7-13)22(24,25)26/h3-9,11-12,17,33H,10H2,1-2H3,(H,27,30,31)	HEWNCZLHQDDEPX-UHFFFAOYSA-N	174779	US9688672, Example 80::US10112931, Example 81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1089					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174779&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451905	363892235							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564603	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C22H20ClF3N6O3/c1-11(30-20-27-6-5-18(31-20)32-17(12(2)33)10-35-21(32)34)19-28-8-14(9-29-19)13-3-4-16(23)15(7-13)22(24,25)26/h3-9,11-12,17,33H,10H2,1-2H3,(H,27,30,31)	JZNHXMKFKNAHDQ-UHFFFAOYSA-N	174782	US9688672, Example 83::US10112931, Example 83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 19.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174782&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451906	363892236							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564604	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C22H20ClF3N6O3/c1-11(30-20-27-6-5-18(31-20)32-17(12(2)33)10-35-21(32)34)19-28-8-14(9-29-19)13-3-4-16(23)15(7-13)22(24,25)26/h3-9,11-12,17,33H,10H2,1-2H3,(H,27,30,31)	JZNHXMKFKNAHDQ-UHFFFAOYSA-N	174782	US9688672, Example 83::US10112931, Example 83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 22.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174782&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451906	363892236							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564605	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C22H20ClF3N6O3/c1-11(30-20-27-6-5-18(31-20)32-17(12(2)33)10-35-21(32)34)19-28-8-14(9-29-19)13-3-4-16(23)15(7-13)22(24,25)26/h3-9,11-12,17,33H,10H2,1-2H3,(H,27,30,31)	JZNHXMKFKNAHDQ-UHFFFAOYSA-N	174782	US9688672, Example 83::US10112931, Example 83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 662					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174782&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451906	363892236							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564606	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C22H20ClF3N6O3/c1-11(30-20-27-6-5-18(31-20)32-17(12(2)33)10-35-21(32)34)19-28-8-14(9-29-19)13-3-4-16(23)15(7-13)22(24,25)26/h3-9,11-12,17,33H,10H2,1-2H3,(H,27,30,31)	JZNHXMKFKNAHDQ-UHFFFAOYSA-N	174782	US9688672, Example 83::US10112931, Example 83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 489					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174782&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451906	363892236							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564607	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(Cl)c2)n1 |r,w:15.16|	InChI=1S/C21H20Cl2N6O3/c1-11(19-25-8-14(9-26-19)13-3-4-15(22)16(23)7-13)27-20-24-6-5-18(28-20)29-17(12(2)30)10-32-21(29)31/h3-9,11-12,17,30H,10H2,1-2H3,(H,24,27,28)	FZJHBXOYJXRIDM-UHFFFAOYSA-N	174784	US9688672, Example 85::US10112931, Example 85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174784&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451911	363892237							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564608	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(Cl)c2)n1 |r,w:15.16|	InChI=1S/C21H20Cl2N6O3/c1-11(19-25-8-14(9-26-19)13-3-4-15(22)16(23)7-13)27-20-24-6-5-18(28-20)29-17(12(2)30)10-32-21(29)31/h3-9,11-12,17,30H,10H2,1-2H3,(H,24,27,28)	FZJHBXOYJXRIDM-UHFFFAOYSA-N	174784	US9688672, Example 85::US10112931, Example 85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 13.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174784&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451911	363892237							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564609	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(Cl)c2)n1 |r,w:15.16|	InChI=1S/C21H20Cl2N6O3/c1-11(19-25-8-14(9-26-19)13-3-4-15(22)16(23)7-13)27-20-24-6-5-18(28-20)29-17(12(2)30)10-32-21(29)31/h3-9,11-12,17,30H,10H2,1-2H3,(H,24,27,28)	FZJHBXOYJXRIDM-UHFFFAOYSA-N	174784	US9688672, Example 85::US10112931, Example 85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1930					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174784&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451911	363892237							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564610	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(Cl)c2)n1 |r,w:15.16|	InChI=1S/C21H20Cl2N6O3/c1-11(19-25-8-14(9-26-19)13-3-4-15(22)16(23)7-13)27-20-24-6-5-18(28-20)29-17(12(2)30)10-32-21(29)31/h3-9,11-12,17,30H,10H2,1-2H3,(H,24,27,28)	FZJHBXOYJXRIDM-UHFFFAOYSA-N	174784	US9688672, Example 85::US10112931, Example 85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 524					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174784&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451911	363892237							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564611	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cccc(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C22H21F3N6O3/c1-12(19-27-9-15(10-28-19)14-4-3-5-16(8-14)22(23,24)25)29-20-26-7-6-18(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,26,29,30)	VTTHQMCVZHLBRX-UHFFFAOYSA-N	174785	US9688672, Example 87::US10112931, Example 87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 32.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174785&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451872	363892238							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564612	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cccc(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C22H21F3N6O3/c1-12(19-27-9-15(10-28-19)14-4-3-5-16(8-14)22(23,24)25)29-20-26-7-6-18(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,26,29,30)	VTTHQMCVZHLBRX-UHFFFAOYSA-N	174785	US9688672, Example 87::US10112931, Example 87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 19.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174785&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451872	363892238							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564613	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cccc(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C22H21F3N6O3/c1-12(19-27-9-15(10-28-19)14-4-3-5-16(8-14)22(23,24)25)29-20-26-7-6-18(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,26,29,30)	VTTHQMCVZHLBRX-UHFFFAOYSA-N	174785	US9688672, Example 87::US10112931, Example 87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 6690					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174785&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451872	363892238							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564614	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cccc(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C22H21F3N6O3/c1-12(19-27-9-15(10-28-19)14-4-3-5-16(8-14)22(23,24)25)29-20-26-7-6-18(30-20)31-17(13(2)32)11-34-21(31)33/h3-10,12-13,17,32H,11H2,1-2H3,(H,26,29,30)	VTTHQMCVZHLBRX-UHFFFAOYSA-N	174785	US9688672, Example 87::US10112931, Example 87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>5000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174785&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451872	363892238							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564615	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(C)c2)n1 |r,w:15.16|	InChI=1S/C22H23ClN6O3/c1-12-8-15(4-5-17(12)23)16-9-25-20(26-10-16)13(2)27-21-24-7-6-19(28-21)29-18(14(3)30)11-32-22(29)31/h4-10,13-14,18,30H,11H2,1-3H3,(H,24,27,28)	NGGVZAHPAFVHHU-UHFFFAOYSA-N	174786	US9688672, Example 89::US10112931, Example 89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 48.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174786&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451910	363892239							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564616	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(C)c2)n1 |r,w:15.16|	InChI=1S/C22H23ClN6O3/c1-12-8-15(4-5-17(12)23)16-9-25-20(26-10-16)13(2)27-21-24-7-6-19(28-21)29-18(14(3)30)11-32-22(29)31/h4-10,13-14,18,30H,11H2,1-3H3,(H,24,27,28)	NGGVZAHPAFVHHU-UHFFFAOYSA-N	174786	US9688672, Example 89::US10112931, Example 89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 34.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174786&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451910	363892239							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564617	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(C)c2)n1 |r,w:15.16|	InChI=1S/C22H23ClN6O3/c1-12-8-15(4-5-17(12)23)16-9-25-20(26-10-16)13(2)27-21-24-7-6-19(28-21)29-18(14(3)30)11-32-22(29)31/h4-10,13-14,18,30H,11H2,1-3H3,(H,24,27,28)	NGGVZAHPAFVHHU-UHFFFAOYSA-N	174786	US9688672, Example 89::US10112931, Example 89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1360					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174786&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451910	363892239							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564618	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(C)c2)n1 |r,w:15.16|	InChI=1S/C22H23ClN6O3/c1-12-8-15(4-5-17(12)23)16-9-25-20(26-10-16)13(2)27-21-24-7-6-19(28-21)29-18(14(3)30)11-32-22(29)31/h4-10,13-14,18,30H,11H2,1-3H3,(H,24,27,28)	NGGVZAHPAFVHHU-UHFFFAOYSA-N	174786	US9688672, Example 89::US10112931, Example 89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1776					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174786&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451910	363892239							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564619	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cc(Cl)cc(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C22H20ClF3N6O3/c1-11(30-20-27-4-3-18(31-20)32-17(12(2)33)10-35-21(32)34)19-28-8-14(9-29-19)13-5-15(22(24,25)26)7-16(23)6-13/h3-9,11-12,17,33H,10H2,1-2H3,(H,27,30,31)	GBALYARIOVJFCR-UHFFFAOYSA-N	174788	US9688672, Example 91::US10112931, Example 91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 34.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174788	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174788&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451912	363892240							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564620	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cc(Cl)cc(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C22H20ClF3N6O3/c1-11(30-20-27-4-3-18(31-20)32-17(12(2)33)10-35-21(32)34)19-28-8-14(9-29-19)13-5-15(22(24,25)26)7-16(23)6-13/h3-9,11-12,17,33H,10H2,1-2H3,(H,27,30,31)	GBALYARIOVJFCR-UHFFFAOYSA-N	174788	US9688672, Example 91::US10112931, Example 91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 13.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174788	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174788&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451912	363892240							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564621	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cc(Cl)cc(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C22H20ClF3N6O3/c1-11(30-20-27-4-3-18(31-20)32-17(12(2)33)10-35-21(32)34)19-28-8-14(9-29-19)13-5-15(22(24,25)26)7-16(23)6-13/h3-9,11-12,17,33H,10H2,1-2H3,(H,27,30,31)	GBALYARIOVJFCR-UHFFFAOYSA-N	174788	US9688672, Example 91::US10112931, Example 91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 274					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174788	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174788&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451912	363892240							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564622	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)cc2)n1 |r,w:15.16|	InChI=1S/C19H19ClN6O4/c1-10(17-24-16(25-30-17)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	HUKBLSVUBDBPMC-UHFFFAOYSA-N	174789	US9688672, Example 93::US10112931, Example 93	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2740					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174789&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451914	363892241							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564623	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)cc2)n1 |r,w:15.16|	InChI=1S/C19H19ClN6O4/c1-10(17-24-16(25-30-17)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	HUKBLSVUBDBPMC-UHFFFAOYSA-N	174789	US9688672, Example 93::US10112931, Example 93	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2301					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174789&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451914	363892241							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564624	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)cc2)n1 |r,w:15.16|	InChI=1S/C19H19ClN6O4/c1-10(17-24-16(25-30-17)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	HUKBLSVUBDBPMC-UHFFFAOYSA-N	174789	US9688672, Example 93::US10112931, Example 93	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 43.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174789&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451914	363892241							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564625	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)cc2)n1 |r,w:15.16|	InChI=1S/C19H19ClN6O4/c1-10(17-24-16(25-30-17)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	HUKBLSVUBDBPMC-UHFFFAOYSA-N	174789	US9688672, Example 93::US10112931, Example 93	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174789&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451914	363892241							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564626	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccc(F)cc2)n1 |r,w:15.16|	InChI=1S/C19H19FN6O4/c1-10(16-24-25-17(30-16)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	PAHVPGBAKFTYHR-UHFFFAOYSA-N	174791	US9688672, Example 95::US10112931, Example 95	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14900					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174791&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451913	363892242							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564627	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccc(F)cc2)n1 |r,w:15.16|	InChI=1S/C19H19FN6O4/c1-10(16-24-25-17(30-16)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	PAHVPGBAKFTYHR-UHFFFAOYSA-N	174791	US9688672, Example 95::US10112931, Example 95	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 25642					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174791&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451913	363892242							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564628	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccc(F)cc2)n1 |r,w:15.16|	InChI=1S/C19H19FN6O4/c1-10(16-24-25-17(30-16)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	PAHVPGBAKFTYHR-UHFFFAOYSA-N	174791	US9688672, Example 95::US10112931, Example 95	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1530					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174791&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451913	363892242							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564629	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccc(F)cc2)n1 |r,w:15.16|	InChI=1S/C19H19FN6O4/c1-10(16-24-25-17(30-16)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	PAHVPGBAKFTYHR-UHFFFAOYSA-N	174791	US9688672, Example 95::US10112931, Example 95	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1113					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=174791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=174791&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451913	363892242							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564630	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(CCOc3ccccc3)no2)n1 |r,w:15.16|	InChI=1S/C21H24N6O5/c1-13(19-24-17(26-32-19)9-11-30-15-6-4-3-5-7-15)23-20-22-10-8-18(25-20)27-16(14(2)28)12-31-21(27)29/h3-8,10,13-14,16,28H,9,11-12H2,1-2H3,(H,22,23,25)	DIDRDLJTUVCPRG-UHFFFAOYSA-N	247549	US9688672, Example 97::US9434719, 97::US10112931, Example 97	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>50000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247549&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451916	346542089							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564631	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(CCOc3ccccc3)no2)n1 |r,w:15.16|	InChI=1S/C21H24N6O5/c1-13(19-24-17(26-32-19)9-11-30-15-6-4-3-5-7-15)23-20-22-10-8-18(25-20)27-16(14(2)28)12-31-21(27)29/h3-8,10,13-14,16,28H,9,11-12H2,1-2H3,(H,22,23,25)	DIDRDLJTUVCPRG-UHFFFAOYSA-N	247549	US9688672, Example 97::US9434719, 97::US10112931, Example 97	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 972					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247549&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451916	346542089							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564632	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(CCOc3ccccc3)no2)n1 |r,w:15.16|	InChI=1S/C21H24N6O5/c1-13(19-24-17(26-32-19)9-11-30-15-6-4-3-5-7-15)23-20-22-10-8-18(25-20)27-16(14(2)28)12-31-21(27)29/h3-8,10,13-14,16,28H,9,11-12H2,1-2H3,(H,22,23,25)	DIDRDLJTUVCPRG-UHFFFAOYSA-N	247549	US9688672, Example 97::US9434719, 97::US10112931, Example 97	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 984					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247549&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451916	346542089							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564633	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccc(C)cc2)n1 |r,w:15.16|	InChI=1S/C20H22N6O4/c1-11-4-6-14(7-5-11)18-25-24-17(30-18)12(2)22-19-21-9-8-16(23-19)26-15(13(3)27)10-29-20(26)28/h4-9,12-13,15,27H,10H2,1-3H3,(H,21,22,23)	FXPWKPAUTKSPOQ-UHFFFAOYSA-N	247550	US9688672, Example 99::US9434719, 99::US10112931, Example 99	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 351					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247550&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451915	346542090							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564634	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccc(C)cc2)n1 |r,w:15.16|	InChI=1S/C20H22N6O4/c1-11-4-6-14(7-5-11)18-25-24-17(30-18)12(2)22-19-21-9-8-16(23-19)26-15(13(3)27)10-29-20(26)28/h4-9,12-13,15,27H,10H2,1-3H3,(H,21,22,23)	FXPWKPAUTKSPOQ-UHFFFAOYSA-N	247550	US9688672, Example 99::US9434719, 99::US10112931, Example 99	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 487					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247550&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451915	346542090							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564635	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccc(C)cc2)n1 |r,w:15.16|	InChI=1S/C20H22N6O4/c1-11-4-6-14(7-5-11)18-25-24-17(30-18)12(2)22-19-21-9-8-16(23-19)26-15(13(3)27)10-29-20(26)28/h4-9,12-13,15,27H,10H2,1-3H3,(H,21,22,23)	FXPWKPAUTKSPOQ-UHFFFAOYSA-N	247550	US9688672, Example 99::US9434719, 99::US10112931, Example 99	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 9790					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247550&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451915	346542090							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564636	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccc(C)cc2)n1 |r,w:15.16|	InChI=1S/C20H22N6O4/c1-11-4-6-14(7-5-11)18-25-24-17(30-18)12(2)22-19-21-9-8-16(23-19)26-15(13(3)27)10-29-20(26)28/h4-9,12-13,15,27H,10H2,1-3H3,(H,21,22,23)	FXPWKPAUTKSPOQ-UHFFFAOYSA-N	247550	US9688672, Example 99::US9434719, 99::US10112931, Example 99	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3057					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247550&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451915	346542090							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564637	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)cc2)n1 |r,w:15.16|	InChI=1S/C19H19FN6O4/c1-10(17-24-16(25-30-17)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	USXVCMIURXEHPW-UHFFFAOYSA-N	247551	US9434719, 101::US10112931, Example 101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18066					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247551&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451917	346542091							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564638	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)cc2)n1 |r,w:15.16|	InChI=1S/C19H19FN6O4/c1-10(17-24-16(25-30-17)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	USXVCMIURXEHPW-UHFFFAOYSA-N	247551	US9434719, 101::US10112931, Example 101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 572					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247551&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451917	346542091							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564639	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccccc2F)n1 |r,w:15.16|	InChI=1S/C19H19FN6O4/c1-10(16-24-25-17(30-16)12-5-3-4-6-13(12)20)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	OTBFEAOWNAZLKM-UHFFFAOYSA-N	247552	US9434719, 103::US10112931, Example 103	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>50000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247552&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451920	346542092							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564640	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccccc2F)n1 |r,w:15.16|	InChI=1S/C19H19FN6O4/c1-10(16-24-25-17(30-16)12-5-3-4-6-13(12)20)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	OTBFEAOWNAZLKM-UHFFFAOYSA-N	247552	US9434719, 103::US10112931, Example 103	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 6354					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247552&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451920	346542092							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564641	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2cccc(C)c2)n1 |r,w:15.16|	InChI=1S/C20H22N6O4/c1-11-5-4-6-14(9-11)18-25-24-17(30-18)12(2)22-19-21-8-7-16(23-19)26-15(13(3)27)10-29-20(26)28/h4-9,12-13,15,27H,10H2,1-3H3,(H,21,22,23)	PRKYEWVCKHGIFQ-UHFFFAOYSA-N	247553	US9688672, Example 105::US9434719, 105::US10112931, Example 105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247553&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451922	346542093							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564642	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2cccc(C)c2)n1 |r,w:15.16|	InChI=1S/C20H22N6O4/c1-11-5-4-6-14(9-11)18-25-24-17(30-18)12(2)22-19-21-8-7-16(23-19)26-15(13(3)27)10-29-20(26)28/h4-9,12-13,15,27H,10H2,1-3H3,(H,21,22,23)	PRKYEWVCKHGIFQ-UHFFFAOYSA-N	247553	US9688672, Example 105::US9434719, 105::US10112931, Example 105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>50000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247553&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451922	346542093							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564643	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2cccc(C)c2)n1 |r,w:15.16|	InChI=1S/C20H22N6O4/c1-11-5-4-6-14(9-11)18-25-24-17(30-18)12(2)22-19-21-8-7-16(23-19)26-15(13(3)27)10-29-20(26)28/h4-9,12-13,15,27H,10H2,1-3H3,(H,21,22,23)	PRKYEWVCKHGIFQ-UHFFFAOYSA-N	247553	US9688672, Example 105::US9434719, 105::US10112931, Example 105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2430					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247553&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451922	346542093							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564644	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2cccc(C)c2)n1 |r,w:15.16|	InChI=1S/C20H22N6O4/c1-11-5-4-6-14(9-11)18-25-24-17(30-18)12(2)22-19-21-8-7-16(23-19)26-15(13(3)27)10-29-20(26)28/h4-9,12-13,15,27H,10H2,1-3H3,(H,21,22,23)	PRKYEWVCKHGIFQ-UHFFFAOYSA-N	247553	US9688672, Example 105::US9434719, 105::US10112931, Example 105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1720					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247553&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451922	346542093							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564645	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccccc2C)n1 |r,w:15.16|	InChI=1S/C20H22N6O4/c1-11-6-4-5-7-14(11)18-25-24-17(30-18)12(2)22-19-21-9-8-16(23-19)26-15(13(3)27)10-29-20(26)28/h4-9,12-13,15,27H,10H2,1-3H3,(H,21,22,23)	CCYGBRQOYRJHRW-UHFFFAOYSA-N	247554	US9688672, Example 107::US9434719, 107::US10112931, Example 107	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247554&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451926	346542094							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564646	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccccc2C)n1 |r,w:15.16|	InChI=1S/C20H22N6O4/c1-11-6-4-5-7-14(11)18-25-24-17(30-18)12(2)22-19-21-9-8-16(23-19)26-15(13(3)27)10-29-20(26)28/h4-9,12-13,15,27H,10H2,1-3H3,(H,21,22,23)	CCYGBRQOYRJHRW-UHFFFAOYSA-N	247554	US9688672, Example 107::US9434719, 107::US10112931, Example 107	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 32926					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247554&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451926	346542094							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564647	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccccc2C)n1 |r,w:15.16|	InChI=1S/C20H22N6O4/c1-11-6-4-5-7-14(11)18-25-24-17(30-18)12(2)22-19-21-9-8-16(23-19)26-15(13(3)27)10-29-20(26)28/h4-9,12-13,15,27H,10H2,1-3H3,(H,21,22,23)	CCYGBRQOYRJHRW-UHFFFAOYSA-N	247554	US9688672, Example 107::US9434719, 107::US10112931, Example 107	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1220					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247554&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451926	346542094							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564648	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccccc2C)n1 |r,w:15.16|	InChI=1S/C20H22N6O4/c1-11-6-4-5-7-14(11)18-25-24-17(30-18)12(2)22-19-21-9-8-16(23-19)26-15(13(3)27)10-29-20(26)28/h4-9,12-13,15,27H,10H2,1-3H3,(H,21,22,23)	CCYGBRQOYRJHRW-UHFFFAOYSA-N	247554	US9688672, Example 107::US9434719, 107::US10112931, Example 107	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1416					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247554&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451926	346542094							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564649	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(c(C)s2)-c2ccc(Cl)cc2)n1 |r,w:15.16|	InChI=1S/C21H22ClN5O3S/c1-11(19-26-18(13(3)31-19)14-4-6-15(22)7-5-14)24-20-23-9-8-17(25-20)27-16(12(2)28)10-30-21(27)29/h4-9,11-12,16,28H,10H2,1-3H3,(H,23,24,25)	AIVKCQOVERPJLV-UHFFFAOYSA-N	247555	US9688672, Example 109::US9434719, 109::US10112931, Example 109	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11700					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247555&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451927	346542095							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564650	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(c(C)s2)-c2ccc(Cl)cc2)n1 |r,w:15.16|	InChI=1S/C21H22ClN5O3S/c1-11(19-26-18(13(3)31-19)14-4-6-15(22)7-5-14)24-20-23-9-8-17(25-20)27-16(12(2)28)10-30-21(27)29/h4-9,11-12,16,28H,10H2,1-3H3,(H,23,24,25)	AIVKCQOVERPJLV-UHFFFAOYSA-N	247555	US9688672, Example 109::US9434719, 109::US10112931, Example 109	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5902					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247555&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451927	346542095							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564651	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(c(C)s2)-c2ccc(Cl)cc2)n1 |r,w:15.16|	InChI=1S/C21H22ClN5O3S/c1-11(19-26-18(13(3)31-19)14-4-6-15(22)7-5-14)24-20-23-9-8-17(25-20)27-16(12(2)28)10-30-21(27)29/h4-9,11-12,16,28H,10H2,1-3H3,(H,23,24,25)	AIVKCQOVERPJLV-UHFFFAOYSA-N	247555	US9688672, Example 109::US9434719, 109::US10112931, Example 109	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 48.6					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247555&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451927	346542095							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564652	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(c(C)s2)-c2ccc(Cl)cc2)n1 |r,w:15.16|	InChI=1S/C21H22ClN5O3S/c1-11(19-26-18(13(3)31-19)14-4-6-15(22)7-5-14)24-20-23-9-8-17(25-20)27-16(12(2)28)10-30-21(27)29/h4-9,11-12,16,28H,10H2,1-3H3,(H,23,24,25)	AIVKCQOVERPJLV-UHFFFAOYSA-N	247555	US9688672, Example 109::US9434719, 109::US10112931, Example 109	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 136					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247555&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451927	346542095							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564653	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2cccc(F)c2)n1 |r,w:15.16|	InChI=1S/C19H19FN6O4/c1-10(16-24-25-17(30-16)12-4-3-5-13(20)8-12)22-18-21-7-6-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	ILNTZEINCNMYCW-UHFFFAOYSA-N	247556	US9688672, Example 111::US9434719, 111::US10112931, Example 111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247556&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451918	346542096							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564654	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2cccc(F)c2)n1 |r,w:15.16|	InChI=1S/C19H19FN6O4/c1-10(16-24-25-17(30-16)12-4-3-5-13(20)8-12)22-18-21-7-6-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	ILNTZEINCNMYCW-UHFFFAOYSA-N	247556	US9688672, Example 111::US9434719, 111::US10112931, Example 111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 23402					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247556&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451918	346542096							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564655	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2cccc(F)c2)n1 |r,w:15.16|	InChI=1S/C19H19FN6O4/c1-10(16-24-25-17(30-16)12-4-3-5-13(20)8-12)22-18-21-7-6-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	ILNTZEINCNMYCW-UHFFFAOYSA-N	247556	US9688672, Example 111::US9434719, 111::US10112931, Example 111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2780					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247556&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451918	346542096							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564656	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2cccc(F)c2)n1 |r,w:15.16|	InChI=1S/C19H19FN6O4/c1-10(16-24-25-17(30-16)12-4-3-5-13(20)8-12)22-18-21-7-6-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	ILNTZEINCNMYCW-UHFFFAOYSA-N	247556	US9688672, Example 111::US9434719, 111::US10112931, Example 111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3511					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247556&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451918	346542096							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564657	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2cccnc2)n1 |r,w:15.16|	InChI=1S/C18H19N7O4/c1-10(15-23-24-16(29-15)12-4-3-6-19-8-12)21-17-20-7-5-14(22-17)25-13(11(2)26)9-28-18(25)27/h3-8,10-11,13,26H,9H2,1-2H3,(H,20,21,22)	QBZCMJWQPGHZCV-UHFFFAOYSA-N	247557	US9688672, Example 113::US9434719, 113::US10112931, Example 113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247557&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451930	346542097							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564658	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2cccnc2)n1 |r,w:15.16|	InChI=1S/C18H19N7O4/c1-10(15-23-24-16(29-15)12-4-3-6-19-8-12)21-17-20-7-5-14(22-17)25-13(11(2)26)9-28-18(25)27/h3-8,10-11,13,26H,9H2,1-2H3,(H,20,21,22)	QBZCMJWQPGHZCV-UHFFFAOYSA-N	247557	US9688672, Example 113::US9434719, 113::US10112931, Example 113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>50000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247557&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451930	346542097							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564659	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2cccnc2)n1 |r,w:15.16|	InChI=1S/C18H19N7O4/c1-10(15-23-24-16(29-15)12-4-3-6-19-8-12)21-17-20-7-5-14(22-17)25-13(11(2)26)9-28-18(25)27/h3-8,10-11,13,26H,9H2,1-2H3,(H,20,21,22)	QBZCMJWQPGHZCV-UHFFFAOYSA-N	247557	US9688672, Example 113::US9434719, 113::US10112931, Example 113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247557&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451930	346542097							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564660	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2cccnc2)n1 |r,w:15.16|	InChI=1S/C18H19N7O4/c1-10(15-23-24-16(29-15)12-4-3-6-19-8-12)21-17-20-7-5-14(22-17)25-13(11(2)26)9-28-18(25)27/h3-8,10-11,13,26H,9H2,1-2H3,(H,20,21,22)	QBZCMJWQPGHZCV-UHFFFAOYSA-N	247557	US9688672, Example 113::US9434719, 113::US10112931, Example 113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 42325					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247557&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451930	346542097							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564661	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2noc(Cc3ccccc3)n2)n1 |r,w:15.16|	InChI=1S/C20H22N6O4/c1-12(18-24-17(30-25-18)10-14-6-4-3-5-7-14)22-19-21-9-8-16(23-19)26-15(13(2)27)11-29-20(26)28/h3-9,12-13,15,27H,10-11H2,1-2H3,(H,21,22,23)	NBOLFMVBIZMHBG-UHFFFAOYSA-N	247558	US9688672, Example 115::US9434719, 115::US10112931, Example 115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247558&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451934	346542098							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564662	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2noc(Cc3ccccc3)n2)n1 |r,w:15.16|	InChI=1S/C20H22N6O4/c1-12(18-24-17(30-25-18)10-14-6-4-3-5-7-14)22-19-21-9-8-16(23-19)26-15(13(2)27)11-29-20(26)28/h3-9,12-13,15,27H,10-11H2,1-2H3,(H,21,22,23)	NBOLFMVBIZMHBG-UHFFFAOYSA-N	247558	US9688672, Example 115::US9434719, 115::US10112931, Example 115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>50000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247558&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451934	346542098							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564663	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2noc(Cc3ccccc3)n2)n1 |r,w:15.16|	InChI=1S/C20H22N6O4/c1-12(18-24-17(30-25-18)10-14-6-4-3-5-7-14)22-19-21-9-8-16(23-19)26-15(13(2)27)11-29-20(26)28/h3-9,12-13,15,27H,10-11H2,1-2H3,(H,21,22,23)	NBOLFMVBIZMHBG-UHFFFAOYSA-N	247558	US9688672, Example 115::US9434719, 115::US10112931, Example 115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7890					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247558&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451934	346542098							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564664	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2noc(Cc3ccccc3)n2)n1 |r,w:15.16|	InChI=1S/C20H22N6O4/c1-12(18-24-17(30-25-18)10-14-6-4-3-5-7-14)22-19-21-9-8-16(23-19)26-15(13(2)27)11-29-20(26)28/h3-9,12-13,15,27H,10-11H2,1-2H3,(H,21,22,23)	NBOLFMVBIZMHBG-UHFFFAOYSA-N	247558	US9688672, Example 115::US9434719, 115::US10112931, Example 115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3760					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247558&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451934	346542098							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564665	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2noc(Cc3ccccc3)n2)ncc1F |r,w:13.14|	InChI=1S/C20H21FN6O4/c1-11(17-24-16(31-26-17)8-13-6-4-3-5-7-13)23-19-22-9-14(21)18(25-19)27-15(12(2)28)10-30-20(27)29/h3-7,9,11-12,15,28H,8,10H2,1-2H3,(H,22,23,25)	RUTLACTVCZTWSF-UHFFFAOYSA-N	247559	US9688672, Example 117::US9434719, 117::US10112931, Example 117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247559&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451932	346542099							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564666	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2noc(Cc3ccccc3)n2)ncc1F |r,w:13.14|	InChI=1S/C20H21FN6O4/c1-11(17-24-16(31-26-17)8-13-6-4-3-5-7-13)23-19-22-9-14(21)18(25-19)27-15(12(2)28)10-30-20(27)29/h3-7,9,11-12,15,28H,8,10H2,1-2H3,(H,22,23,25)	RUTLACTVCZTWSF-UHFFFAOYSA-N	247559	US9688672, Example 117::US9434719, 117::US10112931, Example 117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>50000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247559&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451932	346542099							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564667	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2noc(Cc3ccccc3)n2)ncc1F |r,w:13.14|	InChI=1S/C20H21FN6O4/c1-11(17-24-16(31-26-17)8-13-6-4-3-5-7-13)23-19-22-9-14(21)18(25-19)27-15(12(2)28)10-30-20(27)29/h3-7,9,11-12,15,28H,8,10H2,1-2H3,(H,22,23,25)	RUTLACTVCZTWSF-UHFFFAOYSA-N	247559	US9688672, Example 117::US9434719, 117::US10112931, Example 117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1410					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247559&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451932	346542099							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564668	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2noc(Cc3ccccc3)n2)ncc1F |r,w:13.14|	InChI=1S/C20H21FN6O4/c1-11(17-24-16(31-26-17)8-13-6-4-3-5-7-13)23-19-22-9-14(21)18(25-19)27-15(12(2)28)10-30-20(27)29/h3-7,9,11-12,15,28H,8,10H2,1-2H3,(H,22,23,25)	RUTLACTVCZTWSF-UHFFFAOYSA-N	247559	US9688672, Example 117::US9434719, 117::US10112931, Example 117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2010					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247559&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451932	346542099							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564669	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Br)cc2)n1 |r,w:15.16|	InChI=1S/C19H19BrN6O4/c1-10(17-24-16(25-30-17)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	QJFYKXSETKYZJA-UHFFFAOYSA-N	247560	US9688672, Example 119::US9434719, 119::US10112931, Example 119	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3560					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247560&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451919	346542100							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564670	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Br)cc2)n1 |r,w:15.16|	InChI=1S/C19H19BrN6O4/c1-10(17-24-16(25-30-17)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	QJFYKXSETKYZJA-UHFFFAOYSA-N	247560	US9688672, Example 119::US9434719, 119::US10112931, Example 119	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1539					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247560&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451919	346542100							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564671	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Br)cc2)n1 |r,w:15.16|	InChI=1S/C19H19BrN6O4/c1-10(17-24-16(25-30-17)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	QJFYKXSETKYZJA-UHFFFAOYSA-N	247560	US9688672, Example 119::US9434719, 119::US10112931, Example 119	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 45.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247560&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451919	346542100							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564672	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Br)cc2)n1 |r,w:15.16|	InChI=1S/C19H19BrN6O4/c1-10(17-24-16(25-30-17)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	QJFYKXSETKYZJA-UHFFFAOYSA-N	247560	US9688672, Example 119::US9434719, 119::US10112931, Example 119	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247560&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451919	346542100							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564673	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(C)c(F)c2)n1 |r,w:15.16|	InChI=1S/C20H21FN6O4/c1-10-4-5-13(8-14(10)21)17-25-18(31-26-17)11(2)23-19-22-7-6-16(24-19)27-15(12(3)28)9-30-20(27)29/h4-8,11-12,15,28H,9H2,1-3H3,(H,22,23,24)	CQNIUVQCNAZHDZ-UHFFFAOYSA-N	247561	US9688672, Example 121::US9434719, 121::US10112931, Example 121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2668					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247561&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451921	346542101							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564674	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(C)c(F)c2)n1 |r,w:15.16|	InChI=1S/C20H21FN6O4/c1-10-4-5-13(8-14(10)21)17-25-18(31-26-17)11(2)23-19-22-7-6-16(24-19)27-15(12(3)28)9-30-20(27)29/h4-8,11-12,15,28H,9H2,1-3H3,(H,22,23,24)	CQNIUVQCNAZHDZ-UHFFFAOYSA-N	247561	US9688672, Example 121::US9434719, 121::US10112931, Example 121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 182					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247561&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451921	346542101							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564675	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(C)c(F)c2)n1 |r,w:15.16|	InChI=1S/C20H21FN6O4/c1-10-4-5-13(8-14(10)21)17-25-18(31-26-17)11(2)23-19-22-7-6-16(24-19)27-15(12(3)28)9-30-20(27)29/h4-8,11-12,15,28H,9H2,1-3H3,(H,22,23,24)	CQNIUVQCNAZHDZ-UHFFFAOYSA-N	247561	US9688672, Example 121::US9434719, 121::US10112931, Example 121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 45.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247561&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451921	346542101							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564676	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(C)c(F)c2)ncc1F |r,w:13.14|	InChI=1S/C20H20F2N6O4/c1-9-4-5-12(6-13(9)21)16-25-18(32-27-16)10(2)24-19-23-7-14(22)17(26-19)28-15(11(3)29)8-31-20(28)30/h4-7,10-11,15,29H,8H2,1-3H3,(H,23,24,26)	SNSAPFWSGVJLEA-UHFFFAOYSA-N	247562	US9688672, Example 123::US9434719, 123::US10112931, Example 123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 370					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247562	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247562&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451928	346542102							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564677	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(C)c(F)c2)ncc1F |r,w:13.14|	InChI=1S/C20H20F2N6O4/c1-9-4-5-12(6-13(9)21)16-25-18(32-27-16)10(2)24-19-23-7-14(22)17(26-19)28-15(11(3)29)8-31-20(28)30/h4-7,10-11,15,29H,8H2,1-3H3,(H,23,24,26)	SNSAPFWSGVJLEA-UHFFFAOYSA-N	247562	US9688672, Example 123::US9434719, 123::US10112931, Example 123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 268					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247562	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247562&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451928	346542102							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564678	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(C)c(F)c2)ncc1F |r,w:13.14|	InChI=1S/C20H20F2N6O4/c1-9-4-5-12(6-13(9)21)16-25-18(32-27-16)10(2)24-19-23-7-14(22)17(26-19)28-15(11(3)29)8-31-20(28)30/h4-7,10-11,15,29H,8H2,1-3H3,(H,23,24,26)	SNSAPFWSGVJLEA-UHFFFAOYSA-N	247562	US9688672, Example 123::US9434719, 123::US10112931, Example 123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247562	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247562&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451928	346542102							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564679	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(C)c(F)c2)ncc1F |r,w:13.14|	InChI=1S/C20H20F2N6O4/c1-9-4-5-12(6-13(9)21)16-25-18(32-27-16)10(2)24-19-23-7-14(22)17(26-19)28-15(11(3)29)8-31-20(28)30/h4-7,10-11,15,29H,8H2,1-3H3,(H,23,24,26)	SNSAPFWSGVJLEA-UHFFFAOYSA-N	247562	US9688672, Example 123::US9434719, 123::US10112931, Example 123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 24.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247562	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247562&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451928	346542102							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564680	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(F)c2)n1 |r,w:15.16|	InChI=1S/C19H18F2N6O4/c1-9(17-25-16(26-31-17)11-3-4-12(20)13(21)7-11)23-18-22-6-5-15(24-18)27-14(10(2)28)8-30-19(27)29/h3-7,9-10,14,28H,8H2,1-2H3,(H,22,23,24)	DNFOGQQVCPUNRQ-UHFFFAOYSA-N	247563	US9688672, Example 125::US9434719, 125::US10112931, Example 125	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18800					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247563&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451923	346542103							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564681	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(F)c2)n1 |r,w:15.16|	InChI=1S/C19H18F2N6O4/c1-9(17-25-16(26-31-17)11-3-4-12(20)13(21)7-11)23-18-22-6-5-15(24-18)27-14(10(2)28)8-30-19(27)29/h3-7,9-10,14,28H,8H2,1-2H3,(H,22,23,24)	DNFOGQQVCPUNRQ-UHFFFAOYSA-N	247563	US9688672, Example 125::US9434719, 125::US10112931, Example 125	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247563&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451923	346542103							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564682	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(F)c2)n1 |r,w:15.16|	InChI=1S/C19H18F2N6O4/c1-9(17-25-16(26-31-17)11-3-4-12(20)13(21)7-11)23-18-22-6-5-15(24-18)27-14(10(2)28)8-30-19(27)29/h3-7,9-10,14,28H,8H2,1-2H3,(H,22,23,24)	DNFOGQQVCPUNRQ-UHFFFAOYSA-N	247563	US9688672, Example 125::US9434719, 125::US10112931, Example 125	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 158					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247563&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451923	346542103							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564683	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(F)c2)n1 |r,w:15.16|	InChI=1S/C19H18F2N6O4/c1-9(17-25-16(26-31-17)11-3-4-12(20)13(21)7-11)23-18-22-6-5-15(24-18)27-14(10(2)28)8-30-19(27)29/h3-7,9-10,14,28H,8H2,1-2H3,(H,22,23,24)	DNFOGQQVCPUNRQ-UHFFFAOYSA-N	247563	US9688672, Example 125::US9434719, 125::US10112931, Example 125	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 206					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247563&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451923	346542103							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564684	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)c(Cl)c2)n1 |r,w:15.16|	InChI=1S/C20H19Cl2N5O4/c1-10(17-8-15(26-31-17)12-3-4-13(21)14(22)7-12)24-19-23-6-5-18(25-19)27-16(11(2)28)9-30-20(27)29/h3-8,10-11,16,28H,9H2,1-2H3,(H,23,24,25)	UGMWZDGPRLEDLZ-UHFFFAOYSA-N	247564	US9688672, Example 127::US9434719, 127::US10112931, Example 127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 274					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247564&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451933	346542104							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564685	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)c(Cl)c2)n1 |r,w:15.16|	InChI=1S/C20H19Cl2N5O4/c1-10(17-8-15(26-31-17)12-3-4-13(21)14(22)7-12)24-19-23-6-5-18(25-19)27-16(11(2)28)9-30-20(27)29/h3-8,10-11,16,28H,9H2,1-2H3,(H,23,24,25)	UGMWZDGPRLEDLZ-UHFFFAOYSA-N	247564	US9688672, Example 127::US9434719, 127::US10112931, Example 127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 216					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247564&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451933	346542104							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564686	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)c(Cl)c2)n1 |r,w:15.16|	InChI=1S/C20H19Cl2N5O4/c1-10(17-8-15(26-31-17)12-3-4-13(21)14(22)7-12)24-19-23-6-5-18(25-19)27-16(11(2)28)9-30-20(27)29/h3-8,10-11,16,28H,9H2,1-2H3,(H,23,24,25)	UGMWZDGPRLEDLZ-UHFFFAOYSA-N	247564	US9688672, Example 127::US9434719, 127::US10112931, Example 127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 32.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247564&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451933	346542104							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564687	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)c(Cl)c2)n1 |r,w:15.16|	InChI=1S/C20H19Cl2N5O4/c1-10(17-8-15(26-31-17)12-3-4-13(21)14(22)7-12)24-19-23-6-5-18(25-19)27-16(11(2)28)9-30-20(27)29/h3-8,10-11,16,28H,9H2,1-2H3,(H,23,24,25)	UGMWZDGPRLEDLZ-UHFFFAOYSA-N	247564	US9688672, Example 127::US9434719, 127::US10112931, Example 127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 25.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247564&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451933	346542104							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564688	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)cc2Cl)n1 |r,w:15.16|	InChI=1S/C20H19Cl2N5O4/c1-10(17-8-15(26-31-17)13-4-3-12(21)7-14(13)22)24-19-23-6-5-18(25-19)27-16(11(2)28)9-30-20(27)29/h3-8,10-11,16,28H,9H2,1-2H3,(H,23,24,25)	FIJAWJNDDPPIQM-UHFFFAOYSA-N	247565	US9688672, Example 129::US9434719, 128::US9434719, 129::US10112931, Example 129	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 50.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247565&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451935	346542105							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564689	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)cc2Cl)n1 |r,w:15.16|	InChI=1S/C20H19Cl2N5O4/c1-10(17-8-15(26-31-17)13-4-3-12(21)7-14(13)22)24-19-23-6-5-18(25-19)27-16(11(2)28)9-30-20(27)29/h3-8,10-11,16,28H,9H2,1-2H3,(H,23,24,25)	FIJAWJNDDPPIQM-UHFFFAOYSA-N	247565	US9688672, Example 129::US9434719, 128::US9434719, 129::US10112931, Example 129	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 71.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247565&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451935	346542105							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564690	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)cc2Cl)n1 |r,w:15.16|	InChI=1S/C20H19Cl2N5O4/c1-10(17-8-15(26-31-17)13-4-3-12(21)7-14(13)22)24-19-23-6-5-18(25-19)27-16(11(2)28)9-30-20(27)29/h3-8,10-11,16,28H,9H2,1-2H3,(H,23,24,25)	FIJAWJNDDPPIQM-UHFFFAOYSA-N	247565	US9688672, Example 129::US9434719, 128::US9434719, 129::US10112931, Example 129	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1800					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247565&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451935	346542105							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564691	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)cc2Cl)n1 |r,w:15.16|	InChI=1S/C20H19Cl2N5O4/c1-10(17-8-15(26-31-17)13-4-3-12(21)7-14(13)22)24-19-23-6-5-18(25-19)27-16(11(2)28)9-30-20(27)29/h3-8,10-11,16,28H,9H2,1-2H3,(H,23,24,25)	FIJAWJNDDPPIQM-UHFFFAOYSA-N	247565	US9688672, Example 129::US9434719, 128::US9434719, 129::US10112931, Example 129	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2814					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247565&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451935	346542105							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564692	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(F)c(F)c2)ncc1F |r,w:13.14|	InChI=1S/C19H17F3N6O4/c1-8(17-25-15(27-32-17)10-3-4-11(20)12(21)5-10)24-18-23-6-13(22)16(26-18)28-14(9(2)29)7-31-19(28)30/h3-6,8-9,14,29H,7H2,1-2H3,(H,23,24,26)	CZKHIFLFSUFAEU-UHFFFAOYSA-N	247566	US9688672, Example 131::US9434719, 131::US10112931, Example 131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1510					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247566&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451924	346542106							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564693	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(F)c(F)c2)ncc1F |r,w:13.14|	InChI=1S/C19H17F3N6O4/c1-8(17-25-15(27-32-17)10-3-4-11(20)12(21)5-10)24-18-23-6-13(22)16(26-18)28-14(9(2)29)7-31-19(28)30/h3-6,8-9,14,29H,7H2,1-2H3,(H,23,24,26)	CZKHIFLFSUFAEU-UHFFFAOYSA-N	247566	US9688672, Example 131::US9434719, 131::US10112931, Example 131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2999					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247566&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451924	346542106							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564694	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(F)c(F)c2)ncc1F |r,w:13.14|	InChI=1S/C19H17F3N6O4/c1-8(17-25-15(27-32-17)10-3-4-11(20)12(21)5-10)24-18-23-6-13(22)16(26-18)28-14(9(2)29)7-31-19(28)30/h3-6,8-9,14,29H,7H2,1-2H3,(H,23,24,26)	CZKHIFLFSUFAEU-UHFFFAOYSA-N	247566	US9688672, Example 131::US9434719, 131::US10112931, Example 131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 56.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247566&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451924	346542106							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564695	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(F)c(F)c2)ncc1F |r,w:13.14|	InChI=1S/C19H17F3N6O4/c1-8(17-25-15(27-32-17)10-3-4-11(20)12(21)5-10)24-18-23-6-13(22)16(26-18)28-14(9(2)29)7-31-19(28)30/h3-6,8-9,14,29H,7H2,1-2H3,(H,23,24,26)	CZKHIFLFSUFAEU-UHFFFAOYSA-N	247566	US9688672, Example 131::US9434719, 131::US10112931, Example 131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 153					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247566&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451924	346542106							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564696	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2cc(no2)-c2ccc(Cl)c(Cl)c2)ncc1F |r,w:13.14|	InChI=1S/C20H18Cl2FN5O4/c1-9(17-6-15(27-32-17)11-3-4-12(21)13(22)5-11)25-19-24-7-14(23)18(26-19)28-16(10(2)29)8-31-20(28)30/h3-7,9-10,16,29H,8H2,1-2H3,(H,24,25,26)	GBGXXLPKYDLGDN-UHFFFAOYSA-N	247567	US9688672, Example 133::US9434719, 133::US10112931, Example 133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 956					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247567&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451925	346542107							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564697	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2cc(no2)-c2ccc(Cl)c(Cl)c2)ncc1F |r,w:13.14|	InChI=1S/C20H18Cl2FN5O4/c1-9(17-6-15(27-32-17)11-3-4-12(21)13(22)5-11)25-19-24-7-14(23)18(26-19)28-16(10(2)29)8-31-20(28)30/h3-7,9-10,16,29H,8H2,1-2H3,(H,24,25,26)	GBGXXLPKYDLGDN-UHFFFAOYSA-N	247567	US9688672, Example 133::US9434719, 133::US10112931, Example 133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1421					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247567&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451925	346542107							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564698	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2cc(no2)-c2ccc(Cl)c(Cl)c2)ncc1F |r,w:13.14|	InChI=1S/C20H18Cl2FN5O4/c1-9(17-6-15(27-32-17)11-3-4-12(21)13(22)5-11)25-19-24-7-14(23)18(26-19)28-16(10(2)29)8-31-20(28)30/h3-7,9-10,16,29H,8H2,1-2H3,(H,24,25,26)	GBGXXLPKYDLGDN-UHFFFAOYSA-N	247567	US9688672, Example 133::US9434719, 133::US10112931, Example 133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7.00					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247567&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451925	346542107							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564699	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2cc(no2)-c2ccc(Cl)c(Cl)c2)ncc1F |r,w:13.14|	InChI=1S/C20H18Cl2FN5O4/c1-9(17-6-15(27-32-17)11-3-4-12(21)13(22)5-11)25-19-24-7-14(23)18(26-19)28-16(10(2)29)8-31-20(28)30/h3-7,9-10,16,29H,8H2,1-2H3,(H,24,25,26)	GBGXXLPKYDLGDN-UHFFFAOYSA-N	247567	US9688672, Example 133::US9434719, 133::US10112931, Example 133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4.00					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247567&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451925	346542107							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564700	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2cc(no2)-c2ccc(Cl)cc2Cl)ncc1F |r,w:13.14|	InChI=1S/C20H18Cl2FN5O4/c1-9(17-6-15(27-32-17)12-4-3-11(21)5-13(12)22)25-19-24-7-14(23)18(26-19)28-16(10(2)29)8-31-20(28)30/h3-7,9-10,16,29H,8H2,1-2H3,(H,24,25,26)	HJSGEOWEKHAQKS-UHFFFAOYSA-N	247568	US9688672, Example 135::US9434719, 135::US10112931, Example 135	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1460					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247568&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451929	346542108							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564701	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2cc(no2)-c2ccc(Cl)cc2Cl)ncc1F |r,w:13.14|	InChI=1S/C20H18Cl2FN5O4/c1-9(17-6-15(27-32-17)12-4-3-11(21)5-13(12)22)25-19-24-7-14(23)18(26-19)28-16(10(2)29)8-31-20(28)30/h3-7,9-10,16,29H,8H2,1-2H3,(H,24,25,26)	HJSGEOWEKHAQKS-UHFFFAOYSA-N	247568	US9688672, Example 135::US9434719, 135::US10112931, Example 135	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2360					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247568&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451929	346542108							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564702	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2cc(no2)-c2ccc(Cl)cc2Cl)ncc1F |r,w:13.14|	InChI=1S/C20H18Cl2FN5O4/c1-9(17-6-15(27-32-17)12-4-3-11(21)5-13(12)22)25-19-24-7-14(23)18(26-19)28-16(10(2)29)8-31-20(28)30/h3-7,9-10,16,29H,8H2,1-2H3,(H,24,25,26)	HJSGEOWEKHAQKS-UHFFFAOYSA-N	247568	US9688672, Example 135::US9434719, 135::US10112931, Example 135	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247568&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451929	346542108							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564703	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2cc(no2)-c2ccc(Cl)cc2Cl)ncc1F |r,w:13.14|	InChI=1S/C20H18Cl2FN5O4/c1-9(17-6-15(27-32-17)12-4-3-11(21)5-13(12)22)25-19-24-7-14(23)18(26-19)28-16(10(2)29)8-31-20(28)30/h3-7,9-10,16,29H,8H2,1-2H3,(H,24,25,26)	HJSGEOWEKHAQKS-UHFFFAOYSA-N	247568	US9688672, Example 135::US9434719, 135::US10112931, Example 135	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 16.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247568&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451929	346542108							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564704	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(cs2)-c2ccc(F)c(Cl)c2)n1 |r,w:15.16|	InChI=1S/C20H19ClFN5O3S/c1-10(18-25-15(9-31-18)12-3-4-14(22)13(21)7-12)24-19-23-6-5-17(26-19)27-16(11(2)28)8-30-20(27)29/h3-7,9-11,16,28H,8H2,1-2H3,(H,23,24,26)	PFONREBTTNAHEI-UHFFFAOYSA-N	247569	US9688672, Example 137::US9434719, 137::US10112931, Example 137	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11300					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247569&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451931	346542109							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564705	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(cs2)-c2ccc(F)c(Cl)c2)n1 |r,w:15.16|	InChI=1S/C20H19ClFN5O3S/c1-10(18-25-15(9-31-18)12-3-4-14(22)13(21)7-12)24-19-23-6-5-17(26-19)27-16(11(2)28)8-30-20(27)29/h3-7,9-11,16,28H,8H2,1-2H3,(H,23,24,26)	PFONREBTTNAHEI-UHFFFAOYSA-N	247569	US9688672, Example 137::US9434719, 137::US10112931, Example 137	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>5000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247569&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451931	346542109							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564706	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(cs2)-c2ccc(F)c(Cl)c2)n1 |r,w:15.16|	InChI=1S/C20H19ClFN5O3S/c1-10(18-25-15(9-31-18)12-3-4-14(22)13(21)7-12)24-19-23-6-5-17(26-19)27-16(11(2)28)8-30-20(27)29/h3-7,9-11,16,28H,8H2,1-2H3,(H,23,24,26)	PFONREBTTNAHEI-UHFFFAOYSA-N	247569	US9688672, Example 137::US9434719, 137::US10112931, Example 137	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1190					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247569&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451931	346542109							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564707	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(cs2)-c2ccc(F)c(Cl)c2)n1 |r,w:15.16|	InChI=1S/C20H19ClFN5O3S/c1-10(18-25-15(9-31-18)12-3-4-14(22)13(21)7-12)24-19-23-6-5-17(26-19)27-16(11(2)28)8-30-20(27)29/h3-7,9-11,16,28H,8H2,1-2H3,(H,23,24,26)	PFONREBTTNAHEI-UHFFFAOYSA-N	247569	US9688672, Example 137::US9434719, 137::US10112931, Example 137	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 294					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247569&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451931	346542109							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564708	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2ncc(cn2)-c2cccc(c2)C(F)(F)F)ncc1F |r,w:13.14|	InChI=1S/C22H20F4N6O3/c1-11(18-27-7-14(8-28-18)13-4-3-5-15(6-13)22(24,25)26)30-20-29-9-16(23)19(31-20)32-17(12(2)33)10-35-21(32)34/h3-9,11-12,17,33H,10H2,1-2H3,(H,29,30,31)	DQWHZZJMALNHIB-UHFFFAOYSA-N	247570	US9688672, Example 139::US9434719, 139::US10112931, Example 139	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247570&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451936	346542110							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564709	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2ncc(cn2)-c2cccc(c2)C(F)(F)F)ncc1F |r,w:13.14|	InChI=1S/C22H20F4N6O3/c1-11(18-27-7-14(8-28-18)13-4-3-5-15(6-13)22(24,25)26)30-20-29-9-16(23)19(31-20)32-17(12(2)33)10-35-21(32)34/h3-9,11-12,17,33H,10H2,1-2H3,(H,29,30,31)	DQWHZZJMALNHIB-UHFFFAOYSA-N	247570	US9688672, Example 139::US9434719, 139::US10112931, Example 139	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 24.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247570&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451936	346542110							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564710	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2ncc(cn2)-c2cccc(c2)C(F)(F)F)ncc1F |r,w:13.14|	InChI=1S/C22H20F4N6O3/c1-11(18-27-7-14(8-28-18)13-4-3-5-15(6-13)22(24,25)26)30-20-29-9-16(23)19(31-20)32-17(12(2)33)10-35-21(32)34/h3-9,11-12,17,33H,10H2,1-2H3,(H,29,30,31)	DQWHZZJMALNHIB-UHFFFAOYSA-N	247570	US9688672, Example 139::US9434719, 139::US10112931, Example 139	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 260					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247570&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451936	346542110							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564711	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2ncc(cn2)-c2cccc(c2)C(F)(F)F)ncc1F |r,w:13.14|	InChI=1S/C22H20F4N6O3/c1-11(18-27-7-14(8-28-18)13-4-3-5-15(6-13)22(24,25)26)30-20-29-9-16(23)19(31-20)32-17(12(2)33)10-35-21(32)34/h3-9,11-12,17,33H,10H2,1-2H3,(H,29,30,31)	DQWHZZJMALNHIB-UHFFFAOYSA-N	247570	US9688672, Example 139::US9434719, 139::US10112931, Example 139	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 146					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247570&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451936	346542110							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564712	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cnc(s2)-c2ccccc2)n1 |r,w:15.16|	InChI=1S/C20H21N5O3S/c1-12(16-10-22-18(29-16)14-6-4-3-5-7-14)23-19-21-9-8-17(24-19)25-15(13(2)26)11-28-20(25)27/h3-10,12-13,15,26H,11H2,1-2H3,(H,21,23,24)	JBIBAWVBYNZUKK-UHFFFAOYSA-N	247571	US9688672, Example 141::US9434719, 141::US10112931, Example 141	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10600					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247571&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451943	346542111							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564713	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cnc(s2)-c2ccccc2)n1 |r,w:15.16|	InChI=1S/C20H21N5O3S/c1-12(16-10-22-18(29-16)14-6-4-3-5-7-14)23-19-21-9-8-17(24-19)25-15(13(2)26)11-28-20(25)27/h3-10,12-13,15,26H,11H2,1-2H3,(H,21,23,24)	JBIBAWVBYNZUKK-UHFFFAOYSA-N	247571	US9688672, Example 141::US9434719, 141::US10112931, Example 141	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4032					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247571&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451943	346542111							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564714	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cnc(s2)-c2ccccc2)n1 |r,w:15.16|	InChI=1S/C20H21N5O3S/c1-12(16-10-22-18(29-16)14-6-4-3-5-7-14)23-19-21-9-8-17(24-19)25-15(13(2)26)11-28-20(25)27/h3-10,12-13,15,26H,11H2,1-2H3,(H,21,23,24)	JBIBAWVBYNZUKK-UHFFFAOYSA-N	247571	US9688672, Example 141::US9434719, 141::US10112931, Example 141	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 660					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247571&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451943	346542111							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564715	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cnc(s2)-c2ccccc2)n1 |r,w:15.16|	InChI=1S/C20H21N5O3S/c1-12(16-10-22-18(29-16)14-6-4-3-5-7-14)23-19-21-9-8-17(24-19)25-15(13(2)26)11-28-20(25)27/h3-10,12-13,15,26H,11H2,1-2H3,(H,21,23,24)	JBIBAWVBYNZUKK-UHFFFAOYSA-N	247571	US9688672, Example 141::US9434719, 141::US10112931, Example 141	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 116					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247571&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451943	346542111							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564716	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(Cl)c2)n1 |r,w:15.16|	InChI=1S/C19H19ClN6O4/c1-10(17-24-16(25-30-17)12-4-3-5-13(20)8-12)22-18-21-7-6-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	VDEXLVZLFHDDEG-UHFFFAOYSA-N	247572	US9688672, Example 143::US9434719, 143::US10112931, Example 143	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247572&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451937	346542112							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564717	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(Cl)c2)n1 |r,w:15.16|	InChI=1S/C19H19ClN6O4/c1-10(17-24-16(25-30-17)12-4-3-5-13(20)8-12)22-18-21-7-6-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	VDEXLVZLFHDDEG-UHFFFAOYSA-N	247572	US9688672, Example 143::US9434719, 143::US10112931, Example 143	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3977					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247572&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451937	346542112							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564718	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(Cl)c2)n1 |r,w:15.16|	InChI=1S/C19H19ClN6O4/c1-10(17-24-16(25-30-17)12-4-3-5-13(20)8-12)22-18-21-7-6-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	VDEXLVZLFHDDEG-UHFFFAOYSA-N	247572	US9688672, Example 143::US9434719, 143::US10112931, Example 143	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 756					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247572&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451937	346542112							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564719	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(Cl)c2)n1 |r,w:15.16|	InChI=1S/C19H19ClN6O4/c1-10(17-24-16(25-30-17)12-4-3-5-13(20)8-12)22-18-21-7-6-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	VDEXLVZLFHDDEG-UHFFFAOYSA-N	247572	US9688672, Example 143::US9434719, 143::US10112931, Example 143	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 572					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247572&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451937	346542112							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564720	CC(C)c1ccc(cc1)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O |r,w:14.16|	InChI=1S/C22H26N6O4/c1-12(2)15-5-7-16(8-6-15)19-26-20(32-27-19)13(3)24-21-23-10-9-18(25-21)28-17(14(4)29)11-31-22(28)30/h5-10,12-14,17,29H,11H2,1-4H3,(H,23,24,25)	WTHXIYPSRHQDSX-UHFFFAOYSA-N	247573	US9688672, Example 145::US9434719, 145::US10112931, Example 145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1670					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247573&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451938	346542113							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564721	CC(C)c1ccc(cc1)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O |r,w:14.16|	InChI=1S/C22H26N6O4/c1-12(2)15-5-7-16(8-6-15)19-26-20(32-27-19)13(3)24-21-23-10-9-18(25-21)28-17(14(4)29)11-31-22(28)30/h5-10,12-14,17,29H,11H2,1-4H3,(H,23,24,25)	WTHXIYPSRHQDSX-UHFFFAOYSA-N	247573	US9688672, Example 145::US9434719, 145::US10112931, Example 145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1685					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247573&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451938	346542113							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564722	CC(C)c1ccc(cc1)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O |r,w:14.16|	InChI=1S/C22H26N6O4/c1-12(2)15-5-7-16(8-6-15)19-26-20(32-27-19)13(3)24-21-23-10-9-18(25-21)28-17(14(4)29)11-31-22(28)30/h5-10,12-14,17,29H,11H2,1-4H3,(H,23,24,25)	WTHXIYPSRHQDSX-UHFFFAOYSA-N	247573	US9688672, Example 145::US9434719, 145::US10112931, Example 145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247573&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451938	346542113							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564723	CC(C)c1ccc(cc1)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O |r,w:14.16|	InChI=1S/C22H26N6O4/c1-12(2)15-5-7-16(8-6-15)19-26-20(32-27-19)13(3)24-21-23-10-9-18(25-21)28-17(14(4)29)11-31-22(28)30/h5-10,12-14,17,29H,11H2,1-4H3,(H,23,24,25)	WTHXIYPSRHQDSX-UHFFFAOYSA-N	247573	US9688672, Example 145::US9434719, 145::US10112931, Example 145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 36.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247573&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451938	346542113							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564724	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccccc2OC(F)(F)F)n1 |r,w:15.16|	InChI=1S/C20H19F3N6O5/c1-10(17-27-16(28-34-17)12-5-3-4-6-14(12)33-20(21,22)23)25-18-24-8-7-15(26-18)29-13(11(2)30)9-32-19(29)31/h3-8,10-11,13,30H,9H2,1-2H3,(H,24,25,26)	LFBAMBIMRLLLJV-UHFFFAOYSA-N	247574	US9434719, 147::US10112931, Example 147	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>5000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247574&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451944	346542114							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564725	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccccc2OC(F)(F)F)n1 |r,w:15.16|	InChI=1S/C20H19F3N6O5/c1-10(17-27-16(28-34-17)12-5-3-4-6-14(12)33-20(21,22)23)25-18-24-8-7-15(26-18)29-13(11(2)30)9-32-19(29)31/h3-8,10-11,13,30H,9H2,1-2H3,(H,24,25,26)	LFBAMBIMRLLLJV-UHFFFAOYSA-N	247574	US9434719, 147::US10112931, Example 147	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 368					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247574&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451944	346542114							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564726	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(C)c2)n1 |r,w:15.16|	InChI=1S/C20H21FN6O4/c1-10-8-13(4-5-14(10)21)17-25-18(31-26-17)11(2)23-19-22-7-6-16(24-19)27-15(12(3)28)9-30-20(27)29/h4-8,11-12,15,28H,9H2,1-3H3,(H,22,23,24)	DBIUWIKBQRDZEO-UHFFFAOYSA-N	247575	US9688672, Example 149::US9434719, 149::US10112931, Example 149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 9590					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247575&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451946	346542115							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564727	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(C)c2)n1 |r,w:15.16|	InChI=1S/C20H21FN6O4/c1-10-8-13(4-5-14(10)21)17-25-18(31-26-17)11(2)23-19-22-7-6-16(24-19)27-15(12(3)28)9-30-20(27)29/h4-8,11-12,15,28H,9H2,1-3H3,(H,22,23,24)	DBIUWIKBQRDZEO-UHFFFAOYSA-N	247575	US9688672, Example 149::US9434719, 149::US10112931, Example 149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>5000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247575&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451946	346542115							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564728	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(C)c2)n1 |r,w:15.16|	InChI=1S/C20H21FN6O4/c1-10-8-13(4-5-14(10)21)17-25-18(31-26-17)11(2)23-19-22-7-6-16(24-19)27-15(12(3)28)9-30-20(27)29/h4-8,11-12,15,28H,9H2,1-3H3,(H,22,23,24)	DBIUWIKBQRDZEO-UHFFFAOYSA-N	247575	US9688672, Example 149::US9434719, 149::US10112931, Example 149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 194					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247575&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451946	346542115							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564729	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(C)c2)n1 |r,w:15.16|	InChI=1S/C20H21FN6O4/c1-10-8-13(4-5-14(10)21)17-25-18(31-26-17)11(2)23-19-22-7-6-16(24-19)27-15(12(3)28)9-30-20(27)29/h4-8,11-12,15,28H,9H2,1-3H3,(H,22,23,24)	DBIUWIKBQRDZEO-UHFFFAOYSA-N	247575	US9688672, Example 149::US9434719, 149::US10112931, Example 149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 168					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247575&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451946	346542115							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564730	CCc1ccc(cc1)-c1noc(n1)C(C)Nc1ncc(F)c(n1)N1[C@H](COC1=O)[C@@H](C)O |r,w:13.15|	InChI=1S/C21H23FN6O4/c1-4-13-5-7-14(8-6-13)17-25-19(32-27-17)11(2)24-20-23-9-15(22)18(26-20)28-16(12(3)29)10-31-21(28)30/h5-9,11-12,16,29H,4,10H2,1-3H3,(H,23,24,26)	QWLOHBWGGKYBOB-UHFFFAOYSA-N	247576	US9434719, 151::US10112931, Example 151	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>5000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247576&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451945	346542116							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564731	CCc1ccc(cc1)-c1noc(n1)C(C)Nc1ncc(F)c(n1)N1[C@H](COC1=O)[C@@H](C)O |r,w:13.15|	InChI=1S/C21H23FN6O4/c1-4-13-5-7-14(8-6-13)17-25-19(32-27-17)11(2)24-20-23-9-15(22)18(26-20)28-16(12(3)29)10-31-21(28)30/h5-9,11-12,16,29H,4,10H2,1-3H3,(H,23,24,26)	QWLOHBWGGKYBOB-UHFFFAOYSA-N	247576	US9434719, 151::US10112931, Example 151	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 43.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247576&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451945	346542116							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564732	CCc1ccc(cc1)-c1noc(n1)C(C)Nc1ncc(F)c(n1)N1[C@H](COC1=O)[C@@H](C)O |r,w:13.15|	InChI=1S/C21H23FN6O4/c1-4-13-5-7-14(8-6-13)17-25-19(32-27-17)11(2)24-20-23-9-15(22)18(26-20)28-16(12(3)29)10-31-21(28)30/h5-9,11-12,16,29H,4,10H2,1-3H3,(H,23,24,26)	QWLOHBWGGKYBOB-UHFFFAOYSA-N	247576	US9434719, 151::US10112931, Example 151	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247576&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451945	346542116							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564733	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccc(C)c(C)c2)n1 |r,w:15.16|	InChI=1S/C21H24N6O4/c1-11-5-6-15(9-12(11)2)19-26-25-18(31-19)13(3)23-20-22-8-7-17(24-20)27-16(14(4)28)10-30-21(27)29/h5-9,13-14,16,28H,10H2,1-4H3,(H,22,23,24)	SQUFVDNRWQHGQO-UHFFFAOYSA-N	247577	US9688672, Example 153::US9434719, 153::US10112931, Example 153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5990					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247577&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451940	346542117							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564734	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccc(C)c(C)c2)n1 |r,w:15.16|	InChI=1S/C21H24N6O4/c1-11-5-6-15(9-12(11)2)19-26-25-18(31-19)13(3)23-20-22-8-7-17(24-20)27-16(14(4)28)10-30-21(27)29/h5-9,13-14,16,28H,10H2,1-4H3,(H,22,23,24)	SQUFVDNRWQHGQO-UHFFFAOYSA-N	247577	US9688672, Example 153::US9434719, 153::US10112931, Example 153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>5000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247577&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451940	346542117							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564735	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccc(C)c(C)c2)n1 |r,w:15.16|	InChI=1S/C21H24N6O4/c1-11-5-6-15(9-12(11)2)19-26-25-18(31-19)13(3)23-20-22-8-7-17(24-20)27-16(14(4)28)10-30-21(27)29/h5-9,13-14,16,28H,10H2,1-4H3,(H,22,23,24)	SQUFVDNRWQHGQO-UHFFFAOYSA-N	247577	US9688672, Example 153::US9434719, 153::US10112931, Example 153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 329					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247577&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451940	346542117							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564736	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nnc(o2)-c2ccc(C)c(C)c2)n1 |r,w:15.16|	InChI=1S/C21H24N6O4/c1-11-5-6-15(9-12(11)2)19-26-25-18(31-19)13(3)23-20-22-8-7-17(24-20)27-16(14(4)28)10-30-21(27)29/h5-9,13-14,16,28H,10H2,1-4H3,(H,22,23,24)	SQUFVDNRWQHGQO-UHFFFAOYSA-N	247577	US9688672, Example 153::US9434719, 153::US10112931, Example 153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 288					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247577&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451940	346542117							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564737	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc3ccncc23)n1 |r,w:15.16|	InChI=1S/C22H21N7O4/c1-12(20-27-19(28-33-20)15-5-3-4-14-6-8-23-10-16(14)15)25-21-24-9-7-18(26-21)29-17(13(2)30)11-32-22(29)31/h3-10,12-13,17,30H,11H2,1-2H3,(H,24,25,26)	HFNDQXDXAMFAAE-UHFFFAOYSA-N	247578	US9688672, Example 155::US9434719, 155::US10112931, Example 155	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1790					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247578&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451954	346542118							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564738	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc3ccncc23)n1 |r,w:15.16|	InChI=1S/C22H21N7O4/c1-12(20-27-19(28-33-20)15-5-3-4-14-6-8-23-10-16(14)15)25-21-24-9-7-18(26-21)29-17(13(2)30)11-32-22(29)31/h3-10,12-13,17,30H,11H2,1-2H3,(H,24,25,26)	HFNDQXDXAMFAAE-UHFFFAOYSA-N	247578	US9688672, Example 155::US9434719, 155::US10112931, Example 155	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3839					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247578&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451954	346542118							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564739	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc3ccncc23)n1 |r,w:15.16|	InChI=1S/C22H21N7O4/c1-12(20-27-19(28-33-20)15-5-3-4-14-6-8-23-10-16(14)15)25-21-24-9-7-18(26-21)29-17(13(2)30)11-32-22(29)31/h3-10,12-13,17,30H,11H2,1-2H3,(H,24,25,26)	HFNDQXDXAMFAAE-UHFFFAOYSA-N	247578	US9688672, Example 155::US9434719, 155::US10112931, Example 155	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 756					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247578&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451954	346542118							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564740	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc3ccncc23)n1 |r,w:15.16|	InChI=1S/C22H21N7O4/c1-12(20-27-19(28-33-20)15-5-3-4-14-6-8-23-10-16(14)15)25-21-24-9-7-18(26-21)29-17(13(2)30)11-32-22(29)31/h3-10,12-13,17,30H,11H2,1-2H3,(H,24,25,26)	HFNDQXDXAMFAAE-UHFFFAOYSA-N	247578	US9688672, Example 155::US9434719, 155::US10112931, Example 155	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 857					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247578&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451954	346542118							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564741	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)cc2C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C20H18ClF3N6O4/c1-9(17-28-16(29-34-17)12-4-3-11(21)7-13(12)20(22,23)24)26-18-25-6-5-15(27-18)30-14(10(2)31)8-33-19(30)32/h3-7,9-10,14,31H,8H2,1-2H3,(H,25,26,27)	UXGRUBLQGMQKGE-UHFFFAOYSA-N	247579	US9688672, Example 157::US9434719, 157::US10112931, Example 157	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2700					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247579&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451947	346542119							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564742	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)cc2C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C20H18ClF3N6O4/c1-9(17-28-16(29-34-17)12-4-3-11(21)7-13(12)20(22,23)24)26-18-25-6-5-15(27-18)30-14(10(2)31)8-33-19(30)32/h3-7,9-10,14,31H,8H2,1-2H3,(H,25,26,27)	UXGRUBLQGMQKGE-UHFFFAOYSA-N	247579	US9688672, Example 157::US9434719, 157::US10112931, Example 157	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1145					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247579&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451947	346542119							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564743	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)cc2C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C20H18ClF3N6O4/c1-9(17-28-16(29-34-17)12-4-3-11(21)7-13(12)20(22,23)24)26-18-25-6-5-15(27-18)30-14(10(2)31)8-33-19(30)32/h3-7,9-10,14,31H,8H2,1-2H3,(H,25,26,27)	UXGRUBLQGMQKGE-UHFFFAOYSA-N	247579	US9688672, Example 157::US9434719, 157::US10112931, Example 157	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 33.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247579&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451947	346542119							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564744	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)cc2C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C20H18ClF3N6O4/c1-9(17-28-16(29-34-17)12-4-3-11(21)7-13(12)20(22,23)24)26-18-25-6-5-15(27-18)30-14(10(2)31)8-33-19(30)32/h3-7,9-10,14,31H,8H2,1-2H3,(H,25,26,27)	UXGRUBLQGMQKGE-UHFFFAOYSA-N	247579	US9688672, Example 157::US9434719, 157::US10112931, Example 157	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 32.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247579&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451947	346542119							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564745	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(cc2)C(C)C)ncc1F |r,w:13.14|	InChI=1S/C22H25FN6O4/c1-11(2)14-5-7-15(8-6-14)18-26-20(33-28-18)12(3)25-21-24-9-16(23)19(27-21)29-17(13(4)30)10-32-22(29)31/h5-9,11-13,17,30H,10H2,1-4H3,(H,24,25,27)	YFKNDHLPDVXSMU-UHFFFAOYSA-N	247580	US9688672, Example 159::US9434719, 159::US10112931, Example 159	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4374					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247580&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451939	346542120							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564746	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(cc2)C(C)C)ncc1F |r,w:13.14|	InChI=1S/C22H25FN6O4/c1-11(2)14-5-7-15(8-6-14)18-26-20(33-28-18)12(3)25-21-24-9-16(23)19(27-21)29-17(13(4)30)10-32-22(29)31/h5-9,11-13,17,30H,10H2,1-4H3,(H,24,25,27)	YFKNDHLPDVXSMU-UHFFFAOYSA-N	247580	US9688672, Example 159::US9434719, 159::US10112931, Example 159	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<15.9					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247580&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451939	346542120							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564747	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(cc2)C(C)C)ncc1F |r,w:13.14|	InChI=1S/C22H25FN6O4/c1-11(2)14-5-7-15(8-6-14)18-26-20(33-28-18)12(3)25-21-24-9-16(23)19(27-21)29-17(13(4)30)10-32-22(29)31/h5-9,11-13,17,30H,10H2,1-4H3,(H,24,25,27)	YFKNDHLPDVXSMU-UHFFFAOYSA-N	247580	US9688672, Example 159::US9434719, 159::US10112931, Example 159	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 6.00					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247580&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451939	346542120							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564748	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C20H19F3N6O4/c1-10(17-27-16(28-33-17)12-4-3-5-13(8-12)20(21,22)23)25-18-24-7-6-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)	MNEAZYGMJQUBOF-UHFFFAOYSA-N	247581	US9688672, Example 161::US9434719, 161::US10112931, Example 161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1230					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247581&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451941	346542121							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564749	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C20H19F3N6O4/c1-10(17-27-16(28-33-17)12-4-3-5-13(8-12)20(21,22)23)25-18-24-7-6-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)	MNEAZYGMJQUBOF-UHFFFAOYSA-N	247581	US9688672, Example 161::US9434719, 161::US10112931, Example 161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1115					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247581&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451941	346542121							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564750	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C20H19F3N6O4/c1-10(17-27-16(28-33-17)12-4-3-5-13(8-12)20(21,22)23)25-18-24-7-6-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)	MNEAZYGMJQUBOF-UHFFFAOYSA-N	247581	US9688672, Example 161::US9434719, 161::US10112931, Example 161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 158					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247581&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451941	346542121							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564751	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C20H19F3N6O4/c1-10(17-27-16(28-33-17)12-4-3-5-13(8-12)20(21,22)23)25-18-24-7-6-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)	MNEAZYGMJQUBOF-UHFFFAOYSA-N	247581	US9688672, Example 161::US9434719, 161::US10112931, Example 161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 305					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247581&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451941	346542121							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564752	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(OC(F)(F)F)c2)n1 |r,w:15.16|	InChI=1S/C20H18F4N6O5/c1-9(26-18-25-6-5-15(27-18)30-13(10(2)31)8-33-19(30)32)17-28-16(29-35-17)11-3-4-12(21)14(7-11)34-20(22,23)24/h3-7,9-10,13,31H,8H2,1-2H3,(H,25,26,27)	NVQKTZLJBNQZPU-UHFFFAOYSA-N	247582	US9688672, Example 163::US9434719, 163::US10112931, Example 163	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3620					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247582&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451948	346542122							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564753	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(OC(F)(F)F)c2)n1 |r,w:15.16|	InChI=1S/C20H18F4N6O5/c1-9(26-18-25-6-5-15(27-18)30-13(10(2)31)8-33-19(30)32)17-28-16(29-35-17)11-3-4-12(21)14(7-11)34-20(22,23)24/h3-7,9-10,13,31H,8H2,1-2H3,(H,25,26,27)	NVQKTZLJBNQZPU-UHFFFAOYSA-N	247582	US9688672, Example 163::US9434719, 163::US10112931, Example 163	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>5000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247582&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451948	346542122							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564754	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(OC(F)(F)F)c2)n1 |r,w:15.16|	InChI=1S/C20H18F4N6O5/c1-9(26-18-25-6-5-15(27-18)30-13(10(2)31)8-33-19(30)32)17-28-16(29-35-17)11-3-4-12(21)14(7-11)34-20(22,23)24/h3-7,9-10,13,31H,8H2,1-2H3,(H,25,26,27)	NVQKTZLJBNQZPU-UHFFFAOYSA-N	247582	US9688672, Example 163::US9434719, 163::US10112931, Example 163	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 79.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247582&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451948	346542122							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564755	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(F)c(OC(F)(F)F)c2)n1 |r,w:15.16|	InChI=1S/C20H18F4N6O5/c1-9(26-18-25-6-5-15(27-18)30-13(10(2)31)8-33-19(30)32)17-28-16(29-35-17)11-3-4-12(21)14(7-11)34-20(22,23)24/h3-7,9-10,13,31H,8H2,1-2H3,(H,25,26,27)	NVQKTZLJBNQZPU-UHFFFAOYSA-N	247582	US9688672, Example 163::US9434719, 163::US10112931, Example 163	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 152					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247582&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451948	346542122							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564756	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(OC(F)F)c2)n1 |r,w:15.16|	InChI=1S/C20H20F2N6O5/c1-10(17-26-16(27-33-17)12-4-3-5-13(8-12)32-18(21)22)24-19-23-7-6-15(25-19)28-14(11(2)29)9-31-20(28)30/h3-8,10-11,14,18,29H,9H2,1-2H3,(H,23,24,25)	ZTGPIJZQTRQNGI-UHFFFAOYSA-N	247583	US9688672, Example 165::US9434719, 165::US10112931, Example 165	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4680					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247583&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451949	346542123							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564757	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(OC(F)F)c2)n1 |r,w:15.16|	InChI=1S/C20H20F2N6O5/c1-10(17-26-16(27-33-17)12-4-3-5-13(8-12)32-18(21)22)24-19-23-7-6-15(25-19)28-14(11(2)29)9-31-20(28)30/h3-8,10-11,14,18,29H,9H2,1-2H3,(H,23,24,25)	ZTGPIJZQTRQNGI-UHFFFAOYSA-N	247583	US9688672, Example 165::US9434719, 165::US10112931, Example 165	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>5000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247583&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451949	346542123							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564758	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(OC(F)F)c2)n1 |r,w:15.16|	InChI=1S/C20H20F2N6O5/c1-10(17-26-16(27-33-17)12-4-3-5-13(8-12)32-18(21)22)24-19-23-7-6-15(25-19)28-14(11(2)29)9-31-20(28)30/h3-8,10-11,14,18,29H,9H2,1-2H3,(H,23,24,25)	ZTGPIJZQTRQNGI-UHFFFAOYSA-N	247583	US9688672, Example 165::US9434719, 165::US10112931, Example 165	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 152					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247583&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451949	346542123							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564759	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(OC(F)F)c2)n1 |r,w:15.16|	InChI=1S/C20H20F2N6O5/c1-10(17-26-16(27-33-17)12-4-3-5-13(8-12)32-18(21)22)24-19-23-7-6-15(25-19)28-14(11(2)29)9-31-20(28)30/h3-8,10-11,14,18,29H,9H2,1-2H3,(H,23,24,25)	ZTGPIJZQTRQNGI-UHFFFAOYSA-N	247583	US9688672, Example 165::US9434719, 165::US10112931, Example 165	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 304					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247583&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451949	346542123							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564760	COc1cc(ccc1Cl)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O |r,w:14.16|	InChI=1S/C20H21ClN6O5/c1-10(18-25-17(26-32-18)12-4-5-13(21)15(8-12)30-3)23-19-22-7-6-16(24-19)27-14(11(2)28)9-31-20(27)29/h4-8,10-11,14,28H,9H2,1-3H3,(H,22,23,24)	HCGGGZYFGAZWQP-UHFFFAOYSA-N	247584	US9688672, Example 167::US9434719, 167::US10112931, Example 167	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 871					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247584	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247584&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451942	346542124							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564761	COc1cc(ccc1Cl)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O |r,w:14.16|	InChI=1S/C20H21ClN6O5/c1-10(18-25-17(26-32-18)12-4-5-13(21)15(8-12)30-3)23-19-22-7-6-16(24-19)27-14(11(2)28)9-31-20(27)29/h4-8,10-11,14,28H,9H2,1-3H3,(H,22,23,24)	HCGGGZYFGAZWQP-UHFFFAOYSA-N	247584	US9688672, Example 167::US9434719, 167::US10112931, Example 167	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 243					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247584	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247584&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451942	346542124							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564762	COc1cc(ccc1Cl)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O |r,w:14.16|	InChI=1S/C20H21ClN6O5/c1-10(18-25-17(26-32-18)12-4-5-13(21)15(8-12)30-3)23-19-22-7-6-16(24-19)27-14(11(2)28)9-31-20(27)29/h4-8,10-11,14,28H,9H2,1-3H3,(H,22,23,24)	HCGGGZYFGAZWQP-UHFFFAOYSA-N	247584	US9688672, Example 167::US9434719, 167::US10112931, Example 167	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 131					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247584	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247584&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451942	346542124							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564763	COc1cc(ccc1Cl)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O |r,w:14.16|	InChI=1S/C20H21ClN6O5/c1-10(18-25-17(26-32-18)12-4-5-13(21)15(8-12)30-3)23-19-22-7-6-16(24-19)27-14(11(2)28)9-31-20(27)29/h4-8,10-11,14,28H,9H2,1-3H3,(H,22,23,24)	HCGGGZYFGAZWQP-UHFFFAOYSA-N	247584	US9688672, Example 167::US9434719, 167::US10112931, Example 167	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 67.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247584	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247584&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451942	346542124							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564764	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc3OC(F)(F)Oc3c2)n1 |r,w:15.16|	InChI=1S/C20H18F2N6O6/c1-9(24-18-23-6-5-15(25-18)28-12(10(2)29)8-31-19(28)30)17-26-16(27-34-17)11-3-4-13-14(7-11)33-20(21,22)32-13/h3-7,9-10,12,29H,8H2,1-2H3,(H,23,24,25)	RGPKYJCYYMOGBR-UHFFFAOYSA-N	247585	US9688672, Example 169::US9434719, 169::US10112931, Example 169	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3200					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247585&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451955	346542125							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564765	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc3OC(F)(F)Oc3c2)n1 |r,w:15.16|	InChI=1S/C20H18F2N6O6/c1-9(24-18-23-6-5-15(25-18)28-12(10(2)29)8-31-19(28)30)17-26-16(27-34-17)11-3-4-13-14(7-11)33-20(21,22)32-13/h3-7,9-10,12,29H,8H2,1-2H3,(H,23,24,25)	RGPKYJCYYMOGBR-UHFFFAOYSA-N	247585	US9688672, Example 169::US9434719, 169::US10112931, Example 169	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>5000					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247585&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451955	346542125							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564766	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc3OC(F)(F)Oc3c2)n1 |r,w:15.16|	InChI=1S/C20H18F2N6O6/c1-9(24-18-23-6-5-15(25-18)28-12(10(2)29)8-31-19(28)30)17-26-16(27-34-17)11-3-4-13-14(7-11)33-20(21,22)32-13/h3-7,9-10,12,29H,8H2,1-2H3,(H,23,24,25)	RGPKYJCYYMOGBR-UHFFFAOYSA-N	247585	US9688672, Example 169::US9434719, 169::US10112931, Example 169	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 38.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247585&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451955	346542125							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564767	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc3OC(F)(F)Oc3c2)n1 |r,w:15.16|	InChI=1S/C20H18F2N6O6/c1-9(24-18-23-6-5-15(25-18)28-12(10(2)29)8-31-19(28)30)17-26-16(27-34-17)11-3-4-13-14(7-11)33-20(21,22)32-13/h3-7,9-10,12,29H,8H2,1-2H3,(H,23,24,25)	RGPKYJCYYMOGBR-UHFFFAOYSA-N	247585	US9688672, Example 169::US9434719, 169::US10112931, Example 169	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 44.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247585&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451955	346542125							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564768	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)c(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C20H18ClF3N6O4/c1-9(17-28-16(29-34-17)11-3-4-13(21)12(7-11)20(22,23)24)26-18-25-6-5-15(27-18)30-14(10(2)31)8-33-19(30)32/h3-7,9-10,14,31H,8H2,1-2H3,(H,25,26,27)	DNPZDRUUCRRSIU-UHFFFAOYSA-N	247586	US9688672, Example 171::US9434719, 171::US10112931, Example 171	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3690					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247586&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451950	346542126							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564769	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)c(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C20H18ClF3N6O4/c1-9(17-28-16(29-34-17)11-3-4-13(21)12(7-11)20(22,23)24)26-18-25-6-5-15(27-18)30-14(10(2)31)8-33-19(30)32/h3-7,9-10,14,31H,8H2,1-2H3,(H,25,26,27)	DNPZDRUUCRRSIU-UHFFFAOYSA-N	247586	US9688672, Example 171::US9434719, 171::US10112931, Example 171	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1884					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247586&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451950	346542126							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564770	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)c(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C20H18ClF3N6O4/c1-9(17-28-16(29-34-17)11-3-4-13(21)12(7-11)20(22,23)24)26-18-25-6-5-15(27-18)30-14(10(2)31)8-33-19(30)32/h3-7,9-10,14,31H,8H2,1-2H3,(H,25,26,27)	DNPZDRUUCRRSIU-UHFFFAOYSA-N	247586	US9688672, Example 171::US9434719, 171::US10112931, Example 171	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 56.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247586&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451950	346542126							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564771	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)c(c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C20H18ClF3N6O4/c1-9(17-28-16(29-34-17)11-3-4-13(21)12(7-11)20(22,23)24)26-18-25-6-5-15(27-18)30-14(10(2)31)8-33-19(30)32/h3-7,9-10,14,31H,8H2,1-2H3,(H,25,26,27)	DNPZDRUUCRRSIU-UHFFFAOYSA-N	247586	US9688672, Example 171::US9434719, 171::US10112931, Example 171	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 31.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247586&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451950	346542126							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564772	CCc1ccc(cc1)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O |r,w:13.15|	InChI=1S/C21H24N6O4/c1-4-14-5-7-15(8-6-14)18-25-19(31-26-18)12(2)23-20-22-10-9-17(24-20)27-16(13(3)28)11-30-21(27)29/h5-10,12-13,16,28H,4,11H2,1-3H3,(H,22,23,24)	WWQSBBFDNJQGEO-UHFFFAOYSA-N	247587	US9688672, Example 173::US9434719, 173::US10112931, Example 173	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3407					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247587	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247587&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451963	346542127							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564773	CCc1ccc(cc1)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O |r,w:13.15|	InChI=1S/C21H24N6O4/c1-4-14-5-7-15(8-6-14)18-25-19(31-26-18)12(2)23-20-22-10-9-17(24-20)27-16(13(3)28)11-30-21(27)29/h5-10,12-13,16,28H,4,11H2,1-3H3,(H,22,23,24)	WWQSBBFDNJQGEO-UHFFFAOYSA-N	247587	US9688672, Example 173::US9434719, 173::US10112931, Example 173	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 51.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247587	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247587&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451963	346542127							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564774	CCc1ccc(cc1)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O |r,w:13.15|	InChI=1S/C21H24N6O4/c1-4-14-5-7-15(8-6-14)18-25-19(31-26-18)12(2)23-20-22-10-9-17(24-20)27-16(13(3)28)11-30-21(27)29/h5-10,12-13,16,28H,4,11H2,1-3H3,(H,22,23,24)	WWQSBBFDNJQGEO-UHFFFAOYSA-N	247587	US9688672, Example 173::US9434719, 173::US10112931, Example 173	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 40.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247587	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247587&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451963	346542127							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564775	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(cc2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C20H19F3N6O4/c1-10(17-27-16(28-33-17)12-3-5-13(6-4-12)20(21,22)23)25-18-24-8-7-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)	QLENNUPBCLQXOM-UHFFFAOYSA-N	247588	US9688672, Example 175::US9434719, 175::US10112931, Example 175	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 230					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247588&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451964	346542128							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564776	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(cc2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C20H19F3N6O4/c1-10(17-27-16(28-33-17)12-3-5-13(6-4-12)20(21,22)23)25-18-24-8-7-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)	QLENNUPBCLQXOM-UHFFFAOYSA-N	247588	US9688672, Example 175::US9434719, 175::US10112931, Example 175	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 238					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247588&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451964	346542128							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564777	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(cc2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C20H19F3N6O4/c1-10(17-27-16(28-33-17)12-3-5-13(6-4-12)20(21,22)23)25-18-24-8-7-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)	QLENNUPBCLQXOM-UHFFFAOYSA-N	247588	US9688672, Example 175::US9434719, 175::US10112931, Example 175	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 298					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247588&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451964	346542128							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564778	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(cc2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C20H19F3N6O4/c1-10(17-27-16(28-33-17)12-3-5-13(6-4-12)20(21,22)23)25-18-24-8-7-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)	QLENNUPBCLQXOM-UHFFFAOYSA-N	247588	US9688672, Example 175::US9434719, 175::US10112931, Example 175	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 49.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247588&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451964	346542128							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564779	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(CCc3ccccc3)no2)n1 |r,w:15.16|	InChI=1S/C21H24N6O4/c1-13(19-24-17(26-31-19)9-8-15-6-4-3-5-7-15)23-20-22-11-10-18(25-20)27-16(14(2)28)12-30-21(27)29/h3-7,10-11,13-14,16,28H,8-9,12H2,1-2H3,(H,22,23,25)	LXDWPRMFMLFXHK-UHFFFAOYSA-N	247589	US9688672, Example 177::US9434719, 177::US10112931, Example 177	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12400					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247589&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451952	346542129							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564780	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(CCc3ccccc3)no2)n1 |r,w:15.16|	InChI=1S/C21H24N6O4/c1-13(19-24-17(26-31-19)9-8-15-6-4-3-5-7-15)23-20-22-11-10-18(25-20)27-16(14(2)28)12-30-21(27)29/h3-7,10-11,13-14,16,28H,8-9,12H2,1-2H3,(H,22,23,25)	LXDWPRMFMLFXHK-UHFFFAOYSA-N	247589	US9688672, Example 177::US9434719, 177::US10112931, Example 177	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4591					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247589&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451952	346542129							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564781	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(CCc3ccccc3)no2)n1 |r,w:15.16|	InChI=1S/C21H24N6O4/c1-13(19-24-17(26-31-19)9-8-15-6-4-3-5-7-15)23-20-22-11-10-18(25-20)27-16(14(2)28)12-30-21(27)29/h3-7,10-11,13-14,16,28H,8-9,12H2,1-2H3,(H,22,23,25)	LXDWPRMFMLFXHK-UHFFFAOYSA-N	247589	US9688672, Example 177::US9434719, 177::US10112931, Example 177	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1230					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247589&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451952	346542129							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564782	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(CCc3ccccc3)no2)n1 |r,w:15.16|	InChI=1S/C21H24N6O4/c1-13(19-24-17(26-31-19)9-8-15-6-4-3-5-7-15)23-20-22-11-10-18(25-20)27-16(14(2)28)12-30-21(27)29/h3-7,10-11,13-14,16,28H,8-9,12H2,1-2H3,(H,22,23,25)	LXDWPRMFMLFXHK-UHFFFAOYSA-N	247589	US9688672, Example 177::US9434719, 177::US10112931, Example 177	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1587					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247589&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451952	346542129							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564783	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(Cl)c(OC(F)(F)F)c2)ncc1F |r,w:13.14|	InChI=1S/C20H17ClF4N6O5/c1-8(17-28-15(30-36-17)10-3-4-11(21)14(5-10)35-20(23,24)25)27-18-26-6-12(22)16(29-18)31-13(9(2)32)7-34-19(31)33/h3-6,8-9,13,32H,7H2,1-2H3,(H,26,27,29)	WXPAQCJZFINGNQ-UHFFFAOYSA-N	247590	US9688672, Example 179::US9434719, 179::US10112931, Example 179	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 364					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247590	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247590&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451959	346542130							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564784	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(Cl)c(OC(F)(F)F)c2)ncc1F |r,w:13.14|	InChI=1S/C20H17ClF4N6O5/c1-8(17-28-15(30-36-17)10-3-4-11(21)14(5-10)35-20(23,24)25)27-18-26-6-12(22)16(29-18)31-13(9(2)32)7-34-19(31)33/h3-6,8-9,13,32H,7H2,1-2H3,(H,26,27,29)	WXPAQCJZFINGNQ-UHFFFAOYSA-N	247590	US9688672, Example 179::US9434719, 179::US10112931, Example 179	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 77.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247590	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247590&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451959	346542130							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564785	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(Cl)c(OC(F)(F)F)c2)ncc1F |r,w:13.14|	InChI=1S/C20H17ClF4N6O5/c1-8(17-28-15(30-36-17)10-3-4-11(21)14(5-10)35-20(23,24)25)27-18-26-6-12(22)16(29-18)31-13(9(2)32)7-34-19(31)33/h3-6,8-9,13,32H,7H2,1-2H3,(H,26,27,29)	WXPAQCJZFINGNQ-UHFFFAOYSA-N	247590	US9688672, Example 179::US9434719, 179::US10112931, Example 179	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7.00					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247590	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247590&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451959	346542130							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564786	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(no2)-c2ccc(Cl)c(OC(F)(F)F)c2)ncc1F |r,w:13.14|	InChI=1S/C20H17ClF4N6O5/c1-8(17-28-15(30-36-17)10-3-4-11(21)14(5-10)35-20(23,24)25)27-18-26-6-12(22)16(29-18)31-13(9(2)32)7-34-19(31)33/h3-6,8-9,13,32H,7H2,1-2H3,(H,26,27,29)	WXPAQCJZFINGNQ-UHFFFAOYSA-N	247590	US9688672, Example 179::US9434719, 179::US10112931, Example 179	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5.00					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247590	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247590&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451959	346542130							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564787	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(OC(F)(F)F)cc2)n1 |r,w:15.16|	InChI=1S/C20H19F3N6O5/c1-10(17-27-16(28-34-17)12-3-5-13(6-4-12)33-20(21,22)23)25-18-24-8-7-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)	VFQOXIRRHLWYFA-UHFFFAOYSA-N	247591	US9688672, Example 181::US9434719, 181::US10112931, Example 181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247591&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451957	346542131							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564788	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(OC(F)(F)F)cc2)n1 |r,w:15.16|	InChI=1S/C20H19F3N6O5/c1-10(17-27-16(28-34-17)12-3-5-13(6-4-12)33-20(21,22)23)25-18-24-8-7-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)	VFQOXIRRHLWYFA-UHFFFAOYSA-N	247591	US9688672, Example 181::US9434719, 181::US10112931, Example 181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2728					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247591&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451957	346542131							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564789	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(OC(F)(F)F)cc2)n1 |r,w:15.16|	InChI=1S/C20H19F3N6O5/c1-10(17-27-16(28-34-17)12-3-5-13(6-4-12)33-20(21,22)23)25-18-24-8-7-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)	VFQOXIRRHLWYFA-UHFFFAOYSA-N	247591	US9688672, Example 181::US9434719, 181::US10112931, Example 181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 138					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247591&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451957	346542131							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564790	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(OC(F)(F)F)cc2)n1 |r,w:15.16|	InChI=1S/C20H19F3N6O5/c1-10(17-27-16(28-34-17)12-3-5-13(6-4-12)33-20(21,22)23)25-18-24-8-7-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)	VFQOXIRRHLWYFA-UHFFFAOYSA-N	247591	US9688672, Example 181::US9434719, 181::US10112931, Example 181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 122					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247591&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451957	346542131							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564791	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(OCC(F)(F)F)c2)n1 |r,w:15.16|	InChI=1S/C21H21F3N6O5/c1-11(26-19-25-7-6-16(27-19)30-15(12(2)31)9-33-20(30)32)18-28-17(29-35-18)13-4-3-5-14(8-13)34-10-21(22,23)24/h3-8,11-12,15,31H,9-10H2,1-2H3,(H,25,26,27)	QSGYHXIUNUAHLH-UHFFFAOYSA-N	247592	US9688672, Example 183::US9434719, 183::US10112931, Example 183	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1920					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247592&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451966	346542132							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564792	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(OCC(F)(F)F)c2)n1 |r,w:15.16|	InChI=1S/C21H21F3N6O5/c1-11(26-19-25-7-6-16(27-19)30-15(12(2)31)9-33-20(30)32)18-28-17(29-35-18)13-4-3-5-14(8-13)34-10-21(22,23)24/h3-8,11-12,15,31H,9-10H2,1-2H3,(H,25,26,27)	QSGYHXIUNUAHLH-UHFFFAOYSA-N	247592	US9688672, Example 183::US9434719, 183::US10112931, Example 183	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1378					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247592&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451966	346542132							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564793	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(OCC(F)(F)F)c2)n1 |r,w:15.16|	InChI=1S/C21H21F3N6O5/c1-11(26-19-25-7-6-16(27-19)30-15(12(2)31)9-33-20(30)32)18-28-17(29-35-18)13-4-3-5-14(8-13)34-10-21(22,23)24/h3-8,11-12,15,31H,9-10H2,1-2H3,(H,25,26,27)	QSGYHXIUNUAHLH-UHFFFAOYSA-N	247592	US9688672, Example 183::US9434719, 183::US10112931, Example 183	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 128					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247592&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451966	346542132							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564794	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(OCC(F)(F)F)c2)n1 |r,w:15.16|	InChI=1S/C21H21F3N6O5/c1-11(26-19-25-7-6-16(27-19)30-15(12(2)31)9-33-20(30)32)18-28-17(29-35-18)13-4-3-5-14(8-13)34-10-21(22,23)24/h3-8,11-12,15,31H,9-10H2,1-2H3,(H,25,26,27)	QSGYHXIUNUAHLH-UHFFFAOYSA-N	247592	US9688672, Example 183::US9434719, 183::US10112931, Example 183	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 243					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247592&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451966	346542132							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564795	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(C)c(o2)-c2ccc(Cl)cc2)n1 |r,w:15.16|	InChI=1S/C21H22ClN5O4/c1-11-18(14-4-6-15(22)7-5-14)31-19(24-11)12(2)25-20-23-9-8-17(26-20)27-16(13(3)28)10-30-21(27)29/h4-9,12-13,16,28H,10H2,1-3H3,(H,23,25,26)	ADOKVKMNXUWJLY-UHFFFAOYSA-N	247593	US9688672, Example 185::US9434719, 185::US10112931, Example 185	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 502					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247593&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451951	346542133							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564796	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(C)c(o2)-c2ccc(Cl)cc2)n1 |r,w:15.16|	InChI=1S/C21H22ClN5O4/c1-11-18(14-4-6-15(22)7-5-14)31-19(24-11)12(2)25-20-23-9-8-17(26-20)27-16(13(3)28)10-30-21(27)29/h4-9,12-13,16,28H,10H2,1-3H3,(H,23,25,26)	ADOKVKMNXUWJLY-UHFFFAOYSA-N	247593	US9688672, Example 185::US9434719, 185::US10112931, Example 185	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 757					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247593&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451951	346542133							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564797	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(C)c(o2)-c2ccc(Cl)cc2)n1 |r,w:15.16|	InChI=1S/C21H22ClN5O4/c1-11-18(14-4-6-15(22)7-5-14)31-19(24-11)12(2)25-20-23-9-8-17(26-20)27-16(13(3)28)10-30-21(27)29/h4-9,12-13,16,28H,10H2,1-3H3,(H,23,25,26)	ADOKVKMNXUWJLY-UHFFFAOYSA-N	247593	US9688672, Example 185::US9434719, 185::US10112931, Example 185	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 23.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247593&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451951	346542133							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564798	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(C)c(o2)-c2ccc(Cl)cc2)n1 |r,w:15.16|	InChI=1S/C21H22ClN5O4/c1-11-18(14-4-6-15(22)7-5-14)31-19(24-11)12(2)25-20-23-9-8-17(26-20)27-16(13(3)28)10-30-21(27)29/h4-9,12-13,16,28H,10H2,1-3H3,(H,23,25,26)	ADOKVKMNXUWJLY-UHFFFAOYSA-N	247593	US9688672, Example 185::US9434719, 185::US10112931, Example 185	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 21.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247593&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451951	346542133							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564799	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(C)c(o2)-c2ccc(Cl)cc2)ncc1F |r,w:13.14|	InChI=1S/C21H21ClFN5O4/c1-10-17(13-4-6-14(22)7-5-13)32-19(25-10)11(2)26-20-24-8-15(23)18(27-20)28-16(12(3)29)9-31-21(28)30/h4-8,11-12,16,29H,9H2,1-3H3,(H,24,26,27)	HLHUIGPXIQCWLI-UHFFFAOYSA-N	247594	US9688672, Example 187::US9434719, 187::US10112931, Example 187	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2320					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247594&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451960	346542134							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564800	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(C)c(o2)-c2ccc(Cl)cc2)ncc1F |r,w:13.14|	InChI=1S/C21H21ClFN5O4/c1-10-17(13-4-6-14(22)7-5-13)32-19(25-10)11(2)26-20-24-8-15(23)18(27-20)28-16(12(3)29)9-31-21(28)30/h4-8,11-12,16,29H,9H2,1-3H3,(H,24,26,27)	HLHUIGPXIQCWLI-UHFFFAOYSA-N	247594	US9688672, Example 187::US9434719, 187::US10112931, Example 187	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2583					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247594&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451960	346542134							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564801	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(C)c(o2)-c2ccc(Cl)cc2)ncc1F |r,w:13.14|	InChI=1S/C21H21ClFN5O4/c1-10-17(13-4-6-14(22)7-5-13)32-19(25-10)11(2)26-20-24-8-15(23)18(27-20)28-16(12(3)29)9-31-21(28)30/h4-8,11-12,16,29H,9H2,1-3H3,(H,24,26,27)	HLHUIGPXIQCWLI-UHFFFAOYSA-N	247594	US9688672, Example 187::US9434719, 187::US10112931, Example 187	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 22.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247594&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451960	346542134							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564802	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(C)c(o2)-c2ccc(Cl)cc2)ncc1F |r,w:13.14|	InChI=1S/C21H21ClFN5O4/c1-10-17(13-4-6-14(22)7-5-13)32-19(25-10)11(2)26-20-24-8-15(23)18(27-20)28-16(12(3)29)9-31-21(28)30/h4-8,11-12,16,29H,9H2,1-3H3,(H,24,26,27)	HLHUIGPXIQCWLI-UHFFFAOYSA-N	247594	US9688672, Example 187::US9434719, 187::US10112931, Example 187	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10.00					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247594&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451960	346542134							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564803	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(c(C)s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H22ClN5O3S/c1-11(19-26-18(13(3)31-19)14-4-6-15(22)7-5-14)24-20-23-9-8-17(25-20)27-16(12(2)28)10-30-21(27)29/h4-9,11-12,16,28H,10H2,1-3H3,(H,23,24,25)	AIVKCQOVERPJLV-UHFFFAOYSA-N	247595	US9688672, Example 189::US9434719, 189::US10112931, Example 189	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 8380					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247595&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451927	346542135							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564804	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(c(C)s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H22ClN5O3S/c1-11(19-26-18(13(3)31-19)14-4-6-15(22)7-5-14)24-20-23-9-8-17(25-20)27-16(12(2)28)10-30-21(27)29/h4-9,11-12,16,28H,10H2,1-3H3,(H,23,24,25)	AIVKCQOVERPJLV-UHFFFAOYSA-N	247595	US9688672, Example 189::US9434719, 189::US10112931, Example 189	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 64.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247595&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451927	346542135							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564805	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(c(C)s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H22ClN5O3S/c1-11(19-26-18(13(3)31-19)14-4-6-15(22)7-5-14)24-20-23-9-8-17(25-20)27-16(12(2)28)10-30-21(27)29/h4-9,11-12,16,28H,10H2,1-3H3,(H,23,24,25)	AIVKCQOVERPJLV-UHFFFAOYSA-N	247595	US9688672, Example 189::US9434719, 189::US10112931, Example 189	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 156					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247595&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451927	346542135							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564806	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(cs2)-c2ccc(Br)cc2)ncc1F |r|	InChI=1S/C20H19BrFN5O3S/c1-10(18-25-15(9-31-18)12-3-5-13(21)6-4-12)24-19-23-7-14(22)17(26-19)27-16(11(2)28)8-30-20(27)29/h3-7,9-11,16,28H,8H2,1-2H3,(H,23,24,26)	DELZMXCYLPWIQP-UHFFFAOYSA-N	247596	US9688672, Example 191::US9434719, 191::US10112931, Example 191	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 37.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247596&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451968	346542136							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564807	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(cs2)-c2ccc(Br)cc2)ncc1F |r|	InChI=1S/C20H19BrFN5O3S/c1-10(18-25-15(9-31-18)12-3-5-13(21)6-4-12)24-19-23-7-14(22)17(26-19)27-16(11(2)28)8-30-20(27)29/h3-7,9-11,16,28H,8H2,1-2H3,(H,23,24,26)	DELZMXCYLPWIQP-UHFFFAOYSA-N	247596	US9688672, Example 191::US9434719, 191::US10112931, Example 191	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247596&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451968	346542136							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564808	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(cs2)-c2ccc(Br)cc2)ncc1F |r|	InChI=1S/C20H19BrFN5O3S/c1-10(18-25-15(9-31-18)12-3-5-13(21)6-4-12)24-19-23-7-14(22)17(26-19)27-16(11(2)28)8-30-20(27)29/h3-7,9-11,16,28H,8H2,1-2H3,(H,23,24,26)	DELZMXCYLPWIQP-UHFFFAOYSA-N	247596	US9688672, Example 191::US9434719, 191::US10112931, Example 191	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>50000					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247596&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451968	346542136							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564809	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(Cl)c2)ncc1F |r,w:13.14|	InChI=1S/C21H19Cl2FN6O3/c1-10(18-25-6-13(7-26-18)12-3-4-14(22)15(23)5-12)28-20-27-8-16(24)19(29-20)30-17(11(2)31)9-33-21(30)32/h3-8,10-11,17,31H,9H2,1-2H3,(H,27,28,29)	QGEKZNPRAWNBRC-UHFFFAOYSA-N	247597	US9434719, 193::US10112931, Example 193	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10.00					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247597&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451961	346542137							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564810	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2ncc(cn2)-c2ccc(Cl)c(Cl)c2)ncc1F |r,w:13.14|	InChI=1S/C21H19Cl2FN6O3/c1-10(18-25-6-13(7-26-18)12-3-4-14(22)15(23)5-12)28-20-27-8-16(24)19(29-20)30-17(11(2)31)9-33-21(30)32/h3-8,10-11,17,31H,9H2,1-2H3,(H,27,28,29)	QGEKZNPRAWNBRC-UHFFFAOYSA-N	247597	US9434719, 193::US10112931, Example 193	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 358					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247597&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451961	346542137							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564811	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(c(C)c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C23H23F3N6O3/c1-12-8-15(4-5-17(12)23(24,25)26)16-9-28-20(29-10-16)13(2)30-21-27-7-6-19(31-21)32-18(14(3)33)11-35-22(32)34/h4-10,13-14,18,33H,11H2,1-3H3,(H,27,30,31)	IMQCNVNUOCMQLX-UHFFFAOYSA-N	247598	US9688672, Example 195::US9434719, 195::US10112931, Example 195	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 51.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247598&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451953	346542138							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564812	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2ccc(c(C)c2)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C23H23F3N6O3/c1-12-8-15(4-5-17(12)23(24,25)26)16-9-28-20(29-10-16)13(2)30-21-27-7-6-19(31-21)32-18(14(3)33)11-35-22(32)34/h4-10,13-14,18,33H,11H2,1-3H3,(H,27,30,31)	IMQCNVNUOCMQLX-UHFFFAOYSA-N	247598	US9688672, Example 195::US9434719, 195::US10112931, Example 195	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2930					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247598&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451953	346542138							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564813	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(C)c(s2)-c2ccnc(c2)C(C)(C)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C24H27F3N6O3S/c1-12-19(15-6-8-28-17(10-15)23(4,5)24(25,26)27)37-20(30-12)13(2)31-21-29-9-7-18(32-21)33-16(14(3)34)11-36-22(33)35/h6-10,13-14,16,34H,11H2,1-5H3,(H,29,31,32)	USESWMZOECWBKB-UHFFFAOYSA-N	247599	US9688672, Example 197::US9434719, 197::US10112931, Example 197	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<15.9					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247599&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451956	346542139							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564814	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(C)c(s2)-c2ccnc(c2)C(C)(C)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C24H27F3N6O3S/c1-12-19(15-6-8-28-17(10-15)23(4,5)24(25,26)27)37-20(30-12)13(2)31-21-29-9-7-18(32-21)33-16(14(3)34)11-36-22(33)35/h6-10,13-14,16,34H,11H2,1-5H3,(H,29,31,32)	USESWMZOECWBKB-UHFFFAOYSA-N	247599	US9688672, Example 197::US9434719, 197::US10112931, Example 197	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5.00					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247599&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451956	346542139							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564815	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(C)c(s2)-c2ccnc(c2)C(C)(C)C(F)(F)F)n1 |r,w:15.16|	InChI=1S/C24H27F3N6O3S/c1-12-19(15-6-8-28-17(10-15)23(4,5)24(25,26)27)37-20(30-12)13(2)31-21-29-9-7-18(32-21)33-16(14(3)34)11-36-22(33)35/h6-10,13-14,16,34H,11H2,1-5H3,(H,29,31,32)	USESWMZOECWBKB-UHFFFAOYSA-N	247599	US9688672, Example 197::US9434719, 197::US10112931, Example 197	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2010					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247599&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451956	346542139							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564816	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(C)c(s2)-c2ccnc(c2)C(C)(C)C(F)(F)F)ncc1F |r,w:13.14|	InChI=1S/C24H26F4N6O3S/c1-11-18(14-6-7-29-17(8-14)23(4,5)24(26,27)28)38-20(31-11)12(2)32-21-30-9-15(25)19(33-21)34-16(13(3)35)10-37-22(34)36/h6-9,12-13,16,35H,10H2,1-5H3,(H,30,32,33)	UQINMWIGODPXCQ-UHFFFAOYSA-N	247600	US9688672, Example 199::US9434719, 199::US10112931, Example 199	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247600&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451958	346542140							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564817	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2nc(C)c(s2)-c2ccnc(c2)C(C)(C)C(F)(F)F)ncc1F |r,w:13.14|	InChI=1S/C24H26F4N6O3S/c1-11-18(14-6-7-29-17(8-14)23(4,5)24(26,27)28)38-20(31-11)12(2)32-21-30-9-15(25)19(33-21)34-16(13(3)35)10-37-22(34)36/h6-9,12-13,16,35H,10H2,1-5H3,(H,30,32,33)	UQINMWIGODPXCQ-UHFFFAOYSA-N	247600	US9688672, Example 199::US9434719, 199::US10112931, Example 199	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1200					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247600&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451958	346542140							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564818	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cccc(c2F)C(F)(F)F)n1 |r|	InChI=1S/C22H20F4N6O3/c1-11(30-20-27-7-6-17(31-20)32-16(12(2)33)10-35-21(32)34)19-28-8-13(9-29-19)14-4-3-5-15(18(14)23)22(24,25)26/h3-9,11-12,16,33H,10H2,1-2H3,(H,27,30,31)	OMLKQWGXCCTPMV-UHFFFAOYSA-N	247601	US9688672, Example 201::US9434719, 201::US10112931, Example 201	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 43.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247601&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451969	346542141							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564819	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cccc(c2F)C(F)(F)F)n1 |r|	InChI=1S/C22H20F4N6O3/c1-11(30-20-27-7-6-17(31-20)32-16(12(2)33)10-35-21(32)34)19-28-8-13(9-29-19)14-4-3-5-15(18(14)23)22(24,25)26/h3-9,11-12,16,33H,10H2,1-2H3,(H,27,30,31)	OMLKQWGXCCTPMV-UHFFFAOYSA-N	247601	US9688672, Example 201::US9434719, 201::US10112931, Example 201	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5.00					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247601&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451969	346542141							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564820	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2ncc(cn2)-c2cccc(c2F)C(F)(F)F)n1 |r|	InChI=1S/C22H20F4N6O3/c1-11(30-20-27-7-6-17(31-20)32-16(12(2)33)10-35-21(32)34)19-28-8-13(9-29-19)14-4-3-5-15(18(14)23)22(24,25)26/h3-9,11-12,16,33H,10H2,1-2H3,(H,27,30,31)	OMLKQWGXCCTPMV-UHFFFAOYSA-N	247601	US9688672, Example 201::US9434719, 201::US10112931, Example 201	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 344					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247601&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451969	346542141							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564821	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2ncc(o2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H19ClFN5O4/c1-10(18-23-8-16(31-18)12-3-5-13(21)6-4-12)25-19-24-7-14(22)17(26-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,24,25,26)	HEDYPYHSULZALW-UHFFFAOYSA-N	247602	US9688672, Example 203::US9434719, 203::US10112931, Example 203	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1680					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247602&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415519	346542142							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564822	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2ncc(o2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H19ClFN5O4/c1-10(18-23-8-16(31-18)12-3-5-13(21)6-4-12)25-19-24-7-14(22)17(26-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,24,25,26)	HEDYPYHSULZALW-UHFFFAOYSA-N	247602	US9688672, Example 203::US9434719, 203::US10112931, Example 203	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1093					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247602&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415519	346542142							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564823	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2ncc(o2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H19ClFN5O4/c1-10(18-23-8-16(31-18)12-3-5-13(21)6-4-12)25-19-24-7-14(22)17(26-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,24,25,26)	HEDYPYHSULZALW-UHFFFAOYSA-N	247602	US9688672, Example 203::US9434719, 203::US10112931, Example 203	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 16.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247602&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415519	346542142							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564824	C[C@@H](O)[C@H]1COC(=O)N1c1nc(NC(C)c2ncc(o2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H19ClFN5O4/c1-10(18-23-8-16(31-18)12-3-5-13(21)6-4-12)25-19-24-7-14(22)17(26-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,24,25,26)	HEDYPYHSULZALW-UHFFFAOYSA-N	247602	US9688672, Example 203::US9434719, 203::US10112931, Example 203	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 8.00					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247602&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415519	346542142							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564825	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClN5O4/c1-11(17-9-15(25-30-17)13-3-5-14(21)6-4-13)23-19-22-8-7-18(24-19)26-16(12(2)27)10-29-20(26)28/h3-9,11-12,16,27H,10H2,1-2H3,(H,22,23,24)	QCIXJXCZOHQOBC-UHFFFAOYSA-N	247603	US9688672, Example 205::US9434719, 205::US10112931, Example 205	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 26.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247603&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415804	346542143							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564826	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClN5O4/c1-11(17-9-15(25-30-17)13-3-5-14(21)6-4-13)23-19-22-8-7-18(24-19)26-16(12(2)27)10-29-20(26)28/h3-9,11-12,16,27H,10H2,1-2H3,(H,22,23,24)	QCIXJXCZOHQOBC-UHFFFAOYSA-N	247603	US9688672, Example 205::US9434719, 205::US10112931, Example 205	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247603&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415804	346542143							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564827	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClN5O4/c1-11(17-9-15(25-30-17)13-3-5-14(21)6-4-13)23-19-22-8-7-18(24-19)26-16(12(2)27)10-29-20(26)28/h3-9,11-12,16,27H,10H2,1-2H3,(H,22,23,24)	QCIXJXCZOHQOBC-UHFFFAOYSA-N	247603	US9688672, Example 205::US9434719, 205::US10112931, Example 205	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2700					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247603&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415804	346542143							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564828	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc(no2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClN5O4/c1-11(17-9-15(25-30-17)13-3-5-14(21)6-4-13)23-19-22-8-7-18(24-19)26-16(12(2)27)10-29-20(26)28/h3-9,11-12,16,27H,10H2,1-2H3,(H,22,23,24)	QCIXJXCZOHQOBC-UHFFFAOYSA-N	247603	US9688672, Example 205::US9434719, 205::US10112931, Example 205	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2052					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247603&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415804	346542143							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564829	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(o2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClN5O4/c1-11(18-23-9-16(30-18)13-3-5-14(21)6-4-13)24-19-22-8-7-17(25-19)26-15(12(2)27)10-29-20(26)28/h3-9,11-12,15,27H,10H2,1-2H3,(H,22,24,25)	HIUAGIMKSPVCLG-UHFFFAOYSA-N	247604	US9688672, Example 206::US9434719, 206::US10112931, Example 206	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 30.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247604&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269208	346542144							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564830	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(o2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClN5O4/c1-11(18-23-9-16(30-18)13-3-5-14(21)6-4-13)24-19-22-8-7-17(25-19)26-15(12(2)27)10-29-20(26)28/h3-9,11-12,15,27H,10H2,1-2H3,(H,22,24,25)	HIUAGIMKSPVCLG-UHFFFAOYSA-N	247604	US9688672, Example 206::US9434719, 206::US10112931, Example 206	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 22.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247604&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269208	346542144							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564831	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2nc(no2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C19H18Cl2N6O4/c1-9(17-25-16(26-31-17)11-3-5-12(20)6-4-11)22-18-23-14(21)7-15(24-18)27-13(10(2)28)8-30-19(27)29/h3-7,9-10,13,28H,8H2,1-2H3,(H,22,23,24)	NCBFXUOWZFTIAL-UHFFFAOYSA-N	247605	US9688672, Example 207::US9434719, 207 as TFA salt::US10112931, Example 207	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247605&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414365	346542145							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564832	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2nc(no2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C19H18Cl2N6O4/c1-9(17-25-16(26-31-17)11-3-5-12(20)6-4-11)22-18-23-14(21)7-15(24-18)27-13(10(2)28)8-30-19(27)29/h3-7,9-10,13,28H,8H2,1-2H3,(H,22,23,24)	NCBFXUOWZFTIAL-UHFFFAOYSA-N	247605	US9688672, Example 207::US9434719, 207 as TFA salt::US10112931, Example 207	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<22.9					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247605&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414365	346542145							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564833	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(cc2F)C(F)(F)F)n1 |r|	InChI=1S/C18H17ClF4N4O3/c1-8(11-4-3-10(5-12(11)20)18(21,22)23)24-16-25-14(19)6-15(26-16)27-13(9(2)28)7-30-17(27)29/h3-6,8-9,13,28H,7H2,1-2H3,(H,24,25,26)	NXXCBQQBPMJPJP-UHFFFAOYSA-N	247606	US9688672, Example 208::US9434719, 208 as TFA salt::US10112931, Example 208	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 101					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247606&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451962	346542146							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564834	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(cc2F)-c2cnn(C)c2)n1 |r|	InChI=1S/C21H22ClFN6O3/c1-11(15-5-4-13(6-16(15)23)14-8-24-28(3)9-14)25-20-26-18(22)7-19(27-20)29-17(12(2)30)10-32-21(29)31/h4-9,11-12,17,30H,10H2,1-3H3,(H,25,26,27)	XETISXFEDFMUSI-UHFFFAOYSA-N	247607	US9688672, Example 209::US9434719, 209 as TFA salt::US10112931, Example 209	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 87.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247607&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451967	346542147							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564835	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(cc2F)-c2cnn(C)c2)n1 |r|	InChI=1S/C21H22ClFN6O3/c1-11(15-5-4-13(6-16(15)23)14-8-24-28(3)9-14)25-20-26-18(22)7-19(27-20)29-17(12(2)30)10-32-21(29)31/h4-9,11-12,17,30H,10H2,1-3H3,(H,25,26,27)	XETISXFEDFMUSI-UHFFFAOYSA-N	247607	US9688672, Example 209::US9434719, 209 as TFA salt::US10112931, Example 209	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 164					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247607&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451967	346542147							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564836	C[C@@H](O)[C@H]1COC(=O)N1c1cc(nc(N[C@@H](C)c2nc(no2)-c2ccc(Cl)cc2)n1)C(F)F |r|	InChI=1S/C20H19ClF2N6O4/c1-9(18-27-17(28-33-18)11-3-5-12(21)6-4-11)24-19-25-13(16(22)23)7-15(26-19)29-14(10(2)30)8-32-20(29)31/h3-7,9-10,14,16,30H,8H2,1-2H3,(H,24,25,26)	WXLQCKHIONRIQN-UHFFFAOYSA-N	247608	US9688672, Example 210::US9434719, 210 as TFA salt::US10112931, Example 210	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 153					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247608&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451965	346542148							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564837	C[C@@H](O)[C@H]1COC(=O)N1c1cc(nc(N[C@@H](C)c2nc(no2)-c2ccc(Cl)cc2)n1)C(F)F |r|	InChI=1S/C20H19ClF2N6O4/c1-9(18-27-17(28-33-18)11-3-5-12(21)6-4-11)24-19-25-13(16(22)23)7-15(26-19)29-14(10(2)30)8-32-20(29)31/h3-7,9-10,14,16,30H,8H2,1-2H3,(H,24,25,26)	WXLQCKHIONRIQN-UHFFFAOYSA-N	247608	US9688672, Example 210::US9434719, 210 as TFA salt::US10112931, Example 210	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 374					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247608&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451965	346542148							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564838	C[C@@H](O)[C@H]1COC(=O)N1c1cc(nc(N[C@@H](C)c2nc(no2)-c2ccc(Cl)cc2)n1)C(F)(F)F |r|	InChI=1S/C20H18ClF3N6O4/c1-9(17-28-16(29-34-17)11-3-5-12(21)6-4-11)25-18-26-14(20(22,23)24)7-15(27-18)30-13(10(2)31)8-33-19(30)32/h3-7,9-10,13,31H,8H2,1-2H3,(H,25,26,27)	QFFYIIBUJFALQY-UHFFFAOYSA-N	247609	US9688672, Example 211::US9434719, 211 as TFA salt::US10112931, Example 211	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 496					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247609&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451970	346542149							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564839	C[C@@H](O)[C@H]1COC(=O)N1c1cc(nc(N[C@@H](C)c2nc(no2)-c2ccc(Cl)cc2)n1)C(F)(F)F |r|	InChI=1S/C20H18ClF3N6O4/c1-9(17-28-16(29-34-17)11-3-5-12(21)6-4-11)25-18-26-14(20(22,23)24)7-15(27-18)30-13(10(2)31)8-33-19(30)32/h3-7,9-10,13,31H,8H2,1-2H3,(H,25,26,27)	QFFYIIBUJFALQY-UHFFFAOYSA-N	247609	US9688672, Example 211::US9434719, 211 as TFA salt::US10112931, Example 211	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2628					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247609&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451970	346542149							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564840	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(n1)[C@@H](C)c1cc(F)c(cc1F)-c1cnn(C)c1 |r|	InChI=1S/C21H20ClF2N5O3/c1-10(13-4-16(24)14(5-15(13)23)12-7-25-28(3)8-12)20-26-18(22)6-19(27-20)29-17(11(2)30)9-32-21(29)31/h4-8,10-11,17,30H,9H2,1-3H3	DHUAMXPDUGZPMC-UHFFFAOYSA-N	247610	US9688672, Example 212::US9434719, 212 as TFA salt::US10112931, Example 212	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 35.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247610&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451971	346542150							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564841	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(n1)[C@@H](C)c1cc(F)c(cc1F)-c1cnn(C)c1 |r|	InChI=1S/C21H20ClF2N5O3/c1-10(13-4-16(24)14(5-15(13)23)12-7-25-28(3)8-12)20-26-18(22)6-19(27-20)29-17(11(2)30)9-32-21(29)31/h4-8,10-11,17,30H,9H2,1-3H3	DHUAMXPDUGZPMC-UHFFFAOYSA-N	247610	US9688672, Example 212::US9434719, 212 as TFA salt::US10112931, Example 212	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 57.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247610&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451971	346542150							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564842	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H19Cl2N5O4/c1-10(14-7-16(31-26-14)12-3-5-13(21)6-4-12)23-19-24-17(22)8-18(25-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,23,24,25)	IPBYIAIAZKELOY-UHFFFAOYSA-N	175219	US9688672, Example 213::US10112931, Example 213	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175219	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175219&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451973	363892296							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564843	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H19Cl2N5O4/c1-10(14-7-16(31-26-14)12-3-5-13(21)6-4-12)23-19-24-17(22)8-18(25-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,23,24,25)	IPBYIAIAZKELOY-UHFFFAOYSA-N	175219	US9688672, Example 213::US10112931, Example 213	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<22.9					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175219	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175219&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451973	363892296							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564844	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H19Cl2N5O4/c1-10(14-7-16(31-26-14)12-3-5-13(21)6-4-12)23-19-24-17(22)8-18(25-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,23,24,25)	IPBYIAIAZKELOY-UHFFFAOYSA-N	175219	US9688672, Example 213::US10112931, Example 213	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 19.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175219	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175219&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451973	363892296							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564845	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H19Cl2N5O4/c1-10(14-7-16(31-26-14)12-3-5-13(21)6-4-12)23-19-24-17(22)8-18(25-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,23,24,25)	IPBYIAIAZKELOY-UHFFFAOYSA-N	175219	US9688672, Example 213::US10112931, Example 213	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175219	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175219&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451973	363892296							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564846	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(on2)-c2ccccc2)n1 |r|	InChI=1S/C20H20ClN5O4/c1-11(14-8-16(30-25-14)13-6-4-3-5-7-13)22-19-23-17(21)9-18(24-19)26-15(12(2)27)10-29-20(26)28/h3-9,11-12,15,27H,10H2,1-2H3,(H,22,23,24)	XAZFNUFCRZJXGB-UHFFFAOYSA-N	247612	US9688672, Example 214::US9434719, 214 as TFA salt::US10112931, Example 214	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 46.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247612&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451974	346542152							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564847	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(on2)-c2ccccc2)n1 |r|	InChI=1S/C20H20ClN5O4/c1-11(14-8-16(30-25-14)13-6-4-3-5-7-13)22-19-23-17(21)9-18(24-19)26-15(12(2)27)10-29-20(26)28/h3-9,11-12,15,27H,10H2,1-2H3,(H,22,23,24)	XAZFNUFCRZJXGB-UHFFFAOYSA-N	247612	US9688672, Example 214::US9434719, 214 as TFA salt::US10112931, Example 214	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 107					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247612&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451974	346542152							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564848	C[C@@H](O)[C@H]1COC(=O)N1c1cc(F)nc(N[C@@H](C)c2cnn(c2)-c2ccc(F)cc2)n1 |r|	InChI=1S/C20H20F2N6O3/c1-11(13-8-23-27(9-13)15-5-3-14(21)4-6-15)24-19-25-17(22)7-18(26-19)28-16(12(2)29)10-31-20(28)30/h3-9,11-12,16,29H,10H2,1-2H3,(H,24,25,26)	TYFOBZWTJHMKET-UHFFFAOYSA-N	247613	US9688672, Example 215::US9434719, 215 as TFA salt::US10112931, Example 215	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 55.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247613&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118121703	346542153							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564849	C[C@@H](O)[C@H]1COC(=O)N1c1cc(F)nc(N[C@@H](C)c2cnn(c2)-c2ccc(F)cc2)n1 |r|	InChI=1S/C20H20F2N6O3/c1-11(13-8-23-27(9-13)15-5-3-14(21)4-6-15)24-19-25-17(22)7-18(26-19)28-16(12(2)29)10-31-20(28)30/h3-9,11-12,16,29H,10H2,1-2H3,(H,24,25,26)	TYFOBZWTJHMKET-UHFFFAOYSA-N	247613	US9688672, Example 215::US9434719, 215 as TFA salt::US10112931, Example 215	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 106					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247613&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118121703	346542153							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564850	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H19Cl2N5O3S/c1-10(15-8-23-18(31-15)12-3-5-13(21)6-4-12)24-19-25-16(22)7-17(26-19)27-14(11(2)28)9-30-20(27)29/h3-8,10-11,14,28H,9H2,1-2H3,(H,24,25,26)	GATAMUFLGVCKNZ-UHFFFAOYSA-N	247614	US9688672, Example 216::US9434719, 216 as TFA salt::US10112931, Example 216	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4.00					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247614&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451972	346542154							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564851	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H19Cl2N5O3S/c1-10(15-8-23-18(31-15)12-3-5-13(21)6-4-12)24-19-25-16(22)7-17(26-19)27-14(11(2)28)9-30-20(27)29/h3-8,10-11,14,28H,9H2,1-2H3,(H,24,25,26)	GATAMUFLGVCKNZ-UHFFFAOYSA-N	247614	US9688672, Example 216::US9434719, 216 as TFA salt::US10112931, Example 216	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247614&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451972	346542154							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564852	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H19ClFN5O3S/c1-10(16-8-23-18(31-16)12-3-5-13(21)6-4-12)25-19-24-7-14(22)17(26-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,24,25,26)	WUFHWWGCPRCXLY-UHFFFAOYSA-N	247615	US9688672, Example 217::US9434719, 217 as TFA salt::US10112931, Example 217	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247615&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269209	346542155							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564853	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H19ClFN5O3S/c1-10(16-8-23-18(31-16)12-3-5-13(21)6-4-12)25-19-24-7-14(22)17(26-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,24,25,26)	WUFHWWGCPRCXLY-UHFFFAOYSA-N	247615	US9688672, Example 217::US9434719, 217 as TFA salt::US10112931, Example 217	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 19.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247615&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269209	346542155							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564854	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H19ClFN5O4/c1-10(15-7-17(31-26-15)12-3-5-13(21)6-4-12)24-19-23-8-14(22)18(25-19)27-16(11(2)28)9-30-20(27)29/h3-8,10-11,16,28H,9H2,1-2H3,(H,23,24,25)	NFYDSEIEOVKCOW-UHFFFAOYSA-N	247616	US9688672, Example 218::US9434719, 218 as TFA salt::US10112931, Example 218	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 19.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247616&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451976	346542156							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564855	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H19ClFN5O4/c1-10(15-7-17(31-26-15)12-3-5-13(21)6-4-12)24-19-23-8-14(22)18(25-19)27-16(11(2)28)9-30-20(27)29/h3-8,10-11,16,28H,9H2,1-2H3,(H,23,24,25)	NFYDSEIEOVKCOW-UHFFFAOYSA-N	247616	US9688672, Example 218::US9434719, 218 as TFA salt::US10112931, Example 218	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247616&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451976	346542156							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564856	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2nnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C19H18Cl2N6O3S/c1-9(16-25-26-17(31-16)11-3-5-12(20)6-4-11)22-18-23-14(21)7-15(24-18)27-13(10(2)28)8-30-19(27)29/h3-7,9-10,13,28H,8H2,1-2H3,(H,22,23,24)	RAIZFAORMPTPAT-UHFFFAOYSA-N	247617	US9688672, Example 219::US9434719, 219 as TFA salt::US10112931, Example 219	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247617&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451975	346542157							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564857	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2nnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C19H18Cl2N6O3S/c1-9(16-25-26-17(31-16)11-3-5-12(20)6-4-11)22-18-23-14(21)7-15(24-18)27-13(10(2)28)8-30-19(27)29/h3-7,9-10,13,28H,8H2,1-2H3,(H,22,23,24)	RAIZFAORMPTPAT-UHFFFAOYSA-N	247617	US9688672, Example 219::US9434719, 219 as TFA salt::US10112931, Example 219	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 15.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247617&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451975	346542157							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564858	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20Cl2N6O3/c1-11(13-8-23-27(9-13)15-5-3-14(21)4-6-15)24-19-25-17(22)7-18(26-19)28-16(12(2)29)10-31-20(28)30/h3-9,11-12,16,29H,10H2,1-2H3,(H,24,25,26)	GLNIOVVBUOTMDV-UHFFFAOYSA-N	247618	US9688672, Example 220::US9434719, 220 as TFA salt::US10112931, Example 220	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247618&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451977	346542158							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564859	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20Cl2N6O3/c1-11(13-8-23-27(9-13)15-5-3-14(21)4-6-15)24-19-25-17(22)7-18(26-19)28-16(12(2)29)10-31-20(28)30/h3-9,11-12,16,29H,10H2,1-2H3,(H,24,25,26)	GLNIOVVBUOTMDV-UHFFFAOYSA-N	247618	US9688672, Example 220::US9434719, 220 as TFA salt::US10112931, Example 220	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247618&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451977	346542158							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564860	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H20ClFN6O3/c1-11(13-7-24-27(9-13)15-5-3-14(21)4-6-15)25-19-23-8-16(22)18(26-19)28-17(12(2)29)10-31-20(28)30/h3-9,11-12,17,29H,10H2,1-2H3,(H,23,25,26)	GRZJNGBTAXSJAT-UHFFFAOYSA-N	247619	US9688672, Example 221::US9434719, 221::US10112931, Example 221	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 61.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247619&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451978	346542159							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564861	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H20ClFN6O3/c1-11(13-7-24-27(9-13)15-5-3-14(21)4-6-15)25-19-23-8-16(22)18(26-19)28-17(12(2)29)10-31-20(28)30/h3-9,11-12,17,29H,10H2,1-2H3,(H,23,25,26)	GRZJNGBTAXSJAT-UHFFFAOYSA-N	247619	US9688672, Example 221::US9434719, 221::US10112931, Example 221	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 46.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247619&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451978	346542159							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564862	C[C@@H](O)[C@H]1COC(=O)N1c1cc(CF)nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H21ClFN5O4/c1-11(16-8-18(32-27-16)13-3-5-14(22)6-4-13)24-20-25-15(9-23)7-19(26-20)28-17(12(2)29)10-31-21(28)30/h3-8,11-12,17,29H,9-10H2,1-2H3,(H,24,25,26)	XGWSEQREFWTISB-UHFFFAOYSA-N	247620	US9688672, Example 222::US9434719, 222 as TFA salt::US10112931, Example 222	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 47.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247620&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451979	346542160							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564863	C[C@@H](O)[C@H]1COC(=O)N1c1cc(CF)nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H21ClFN5O4/c1-11(16-8-18(32-27-16)13-3-5-14(22)6-4-13)24-20-25-15(9-23)7-19(26-20)28-17(12(2)29)10-31-21(28)30/h3-8,11-12,17,29H,9-10H2,1-2H3,(H,24,25,26)	XGWSEQREFWTISB-UHFFFAOYSA-N	247620	US9688672, Example 222::US9434719, 222 as TFA salt::US10112931, Example 222	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 53.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247620&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451979	346542160							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564864	C[C@@H](O)[C@H]1COC(=O)N1c1cc(CF)nc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H21ClFN5O3S/c1-11(17-9-24-19(32-17)13-3-5-14(22)6-4-13)25-20-26-15(8-23)7-18(27-20)28-16(12(2)29)10-31-21(28)30/h3-7,9,11-12,16,29H,8,10H2,1-2H3,(H,25,26,27)	RAIMVJDXPWQXGV-UHFFFAOYSA-N	247621	US9688672, Example 223::US9434719, 223 as TFA salt::US10112931, Example 223	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 23.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247621&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269210	346542161							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564865	C[C@@H](O)[C@H]1COC(=O)N1c1cc(CF)nc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H21ClFN5O3S/c1-11(17-9-24-19(32-17)13-3-5-14(22)6-4-13)25-20-26-15(8-23)7-18(27-20)28-16(12(2)29)10-31-21(28)30/h3-7,9,11-12,16,29H,8,10H2,1-2H3,(H,25,26,27)	RAIMVJDXPWQXGV-UHFFFAOYSA-N	247621	US9688672, Example 223::US9434719, 223 as TFA salt::US10112931, Example 223	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247621&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269210	346542161							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564866	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClN5O3S/c1-11(16-9-23-18(30-16)13-3-5-14(21)6-4-13)24-19-22-8-7-17(25-19)26-15(12(2)27)10-29-20(26)28/h3-9,11-12,15,27H,10H2,1-2H3,(H,22,24,25)	GVHVMKBUEILJFX-UHFFFAOYSA-N	247622	US9688672, Example 224::US9434719, 224::US10112931, Example 224	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247622&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269412	346542162							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564867	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClN5O3S/c1-11(16-9-23-18(30-16)13-3-5-14(21)6-4-13)24-19-22-8-7-17(25-19)26-15(12(2)27)10-29-20(26)28/h3-9,11-12,15,27H,10H2,1-2H3,(H,22,24,25)	GVHVMKBUEILJFX-UHFFFAOYSA-N	247622	US9688672, Example 224::US9434719, 224::US10112931, Example 224	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 27.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247622&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269412	346542162							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564868	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClN5O3S/c1-11(16-9-23-18(30-16)13-3-5-14(21)6-4-13)24-19-22-8-7-17(25-19)26-15(12(2)27)10-29-20(26)28/h3-9,11-12,15,27H,10H2,1-2H3,(H,22,24,25)	GVHVMKBUEILJFX-UHFFFAOYSA-N	247622	US9688672, Example 224::US9434719, 224::US10112931, Example 224	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247622&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269412	346542162							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564869	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClN5O3S/c1-11(16-9-23-18(30-16)13-3-5-14(21)6-4-13)24-19-22-8-7-17(25-19)26-15(12(2)27)10-29-20(26)28/h3-9,11-12,15,27H,10H2,1-2H3,(H,22,24,25)	GVHVMKBUEILJFX-UHFFFAOYSA-N	247622	US9688672, Example 224::US9434719, 224::US10112931, Example 224	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<22.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247622&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269412	346542162							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564870	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H21ClN6O3/c1-12(14-9-23-26(10-14)16-5-3-15(21)4-6-16)24-19-22-8-7-18(25-19)27-17(13(2)28)11-30-20(27)29/h3-10,12-13,17,28H,11H2,1-2H3,(H,22,24,25)	OQBOQQPZTMRUOB-UHFFFAOYSA-N	247623	US9688672, Example 225::US9434719, 225::US10112931, Example 225	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 37.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247623&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269413	346542163							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564871	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H21ClN6O3/c1-12(14-9-23-26(10-14)16-5-3-15(21)4-6-16)24-19-22-8-7-18(25-19)27-17(13(2)28)11-30-20(27)29/h3-10,12-13,17,28H,11H2,1-2H3,(H,22,24,25)	OQBOQQPZTMRUOB-UHFFFAOYSA-N	247623	US9688672, Example 225::US9434719, 225::US10112931, Example 225	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 63.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247623&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269413	346542163							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564872	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H21ClN6O3/c1-12(14-9-23-26(10-14)16-5-3-15(21)4-6-16)24-19-22-8-7-18(25-19)27-17(13(2)28)11-30-20(27)29/h3-10,12-13,17,28H,11H2,1-2H3,(H,22,24,25)	OQBOQQPZTMRUOB-UHFFFAOYSA-N	247623	US9688672, Example 225::US9434719, 225::US10112931, Example 225	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 28.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247623&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269413	346542163							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564873	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H21ClN6O3/c1-12(14-9-23-26(10-14)16-5-3-15(21)4-6-16)24-19-22-8-7-18(25-19)27-17(13(2)28)11-30-20(27)29/h3-10,12-13,17,28H,11H2,1-2H3,(H,22,24,25)	OQBOQQPZTMRUOB-UHFFFAOYSA-N	247623	US9688672, Example 225::US9434719, 225::US10112931, Example 225	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 38.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247623&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269413	346542163							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564874	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(no2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H19Cl2N5O4/c1-10(16-7-14(26-31-16)12-3-5-13(21)6-4-12)23-19-24-17(22)8-18(25-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,23,24,25)	SFLSLKNYLURLGQ-UHFFFAOYSA-N	247624	US9688672, Example 226::US9434719, 226 as TFA salt::US10112931, Example 226	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 9.00					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247624&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451980	346542164							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564875	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(no2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H19ClFN5O4/c1-10(17-7-15(26-31-17)12-3-5-13(21)6-4-12)24-19-23-8-14(22)18(25-19)27-16(11(2)28)9-30-20(27)29/h3-8,10-11,16,28H,9H2,1-2H3,(H,23,24,25)	AJHHRHLQOWGOMY-UHFFFAOYSA-N	247625	US9688672, Example 227::US9434719, 227 as TFA salt::US10112931, Example 227	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 15.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247625&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451983	346542165							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564876	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(no2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H19ClFN5O4/c1-10(17-7-15(26-31-17)12-3-5-13(21)6-4-12)24-19-23-8-14(22)18(25-19)27-16(11(2)28)9-30-20(27)29/h3-8,10-11,16,28H,9H2,1-2H3,(H,23,24,25)	AJHHRHLQOWGOMY-UHFFFAOYSA-N	247625	US9688672, Example 227::US9434719, 227 as TFA salt::US10112931, Example 227	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 220					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247625&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451983	346542165							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564877	C[C@@H](O)[C@H]1COC(=O)N1c1cc(F)nc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClFN6O3/c1-11(13-8-23-27(9-13)15-5-3-14(21)4-6-15)24-19-25-17(22)7-18(26-19)28-16(12(2)29)10-31-20(28)30/h3-9,11-12,16,29H,10H2,1-2H3,(H,24,25,26)	CUCKGGUBBMYMRU-UHFFFAOYSA-N	247626	US9688672, Example 228::US9434719, 228::US10112931, Example 228	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 19.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247626&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451981	346542166							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564878	C[C@@H](O)[C@H]1COC(=O)N1c1cc(F)nc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClFN6O3/c1-11(13-8-23-27(9-13)15-5-3-14(21)4-6-15)24-19-25-17(22)7-18(26-19)28-16(12(2)29)10-31-20(28)30/h3-9,11-12,16,29H,10H2,1-2H3,(H,24,25,26)	CUCKGGUBBMYMRU-UHFFFAOYSA-N	247626	US9688672, Example 228::US9434719, 228::US10112931, Example 228	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 45.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247626&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451981	346542166							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564879	C[C@@H](O)[C@H]1COC(=O)N1c1cc(F)nc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClFN6O3/c1-11(13-8-23-27(9-13)15-5-3-14(21)4-6-15)24-19-25-17(22)7-18(26-19)28-16(12(2)29)10-31-20(28)30/h3-9,11-12,16,29H,10H2,1-2H3,(H,24,25,26)	CUCKGGUBBMYMRU-UHFFFAOYSA-N	247626	US9688672, Example 228::US9434719, 228::US10112931, Example 228	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247626&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451981	346542166							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564880	C[C@@H](O)[C@H]1COC(=O)N1c1cc(F)nc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClFN6O3/c1-11(13-8-23-27(9-13)15-5-3-14(21)4-6-15)24-19-25-17(22)7-18(26-19)28-16(12(2)29)10-31-20(28)30/h3-9,11-12,16,29H,10H2,1-2H3,(H,24,25,26)	CUCKGGUBBMYMRU-UHFFFAOYSA-N	247626	US9688672, Example 228::US9434719, 228::US10112931, Example 228	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247626&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451981	346542166							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564881	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(on2)-c2ccc(F)cc2)n1 |r|	InChI=1S/C20H19ClFN5O4/c1-10(14-7-16(31-26-14)12-3-5-13(22)6-4-12)23-19-24-17(21)8-18(25-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,23,24,25)	TWNZHXTWQYYGKW-UHFFFAOYSA-N	247627	US9688672, Example 229::US9434719, 229 as TFA salt::US10112931, Example 229	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 54.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247627&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451982	346542167							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564882	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(on2)-c2ccc(F)cc2)n1 |r|	InChI=1S/C20H19ClFN5O4/c1-10(14-7-16(31-26-14)12-3-5-13(22)6-4-12)23-19-24-17(21)8-18(25-19)27-15(11(2)28)9-30-20(27)29/h3-8,10-11,15,28H,9H2,1-2H3,(H,23,24,25)	TWNZHXTWQYYGKW-UHFFFAOYSA-N	247627	US9688672, Example 229::US9434719, 229 as TFA salt::US10112931, Example 229	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 81.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247627&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451982	346542167							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564883	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(CN3CCOCC3)on2)n1 |r|	InChI=1S/C19H25ClN6O5/c1-11(14-7-13(31-24-14)9-25-3-5-29-6-4-25)21-18-22-16(20)8-17(23-18)26-15(12(2)27)10-30-19(26)28/h7-8,11-12,15,27H,3-6,9-10H2,1-2H3,(H,21,22,23)	YSHMQMUGIYMHNN-UHFFFAOYSA-N	247628	US9688672, Example 230::US9434719, 230 as TFA salt::US10112931, Example 230	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247628&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451985	346542168							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564884	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@H](C)c2cc(CN3CCOCC3)on2)n1 |r|	InChI=1S/C19H25ClN6O5/c1-11(14-7-13(31-24-14)9-25-3-5-29-6-4-25)21-18-22-16(20)8-17(23-18)26-15(12(2)27)10-30-19(26)28/h7-8,11-12,15,27H,3-6,9-10H2,1-2H3,(H,21,22,23)	YSHMQMUGIYMHNN-UHFFFAOYSA-N	247629	US9688672, Example 231::US9434719, 231 as TFA salt::US10112931, Example 231	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247629&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451984	346542169							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564885	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H23ClN6O3/c1-12-8-19(28-18(14(3)29)11-31-21(28)30)26-20(24-12)25-13(2)15-9-23-27(10-15)17-6-4-16(22)5-7-17/h4-10,13-14,18,29H,11H2,1-3H3,(H,24,25,26)	IBQFUTIPFZCCSX-UHFFFAOYSA-N	247630	US9688672, Example 232::US9434719, 232 as TFA salt::US10112931, Example 232	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 24.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247630&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451990	346542170							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564886	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H23ClN6O3/c1-12-8-19(28-18(14(3)29)11-31-21(28)30)26-20(24-12)25-13(2)15-9-23-27(10-15)17-6-4-16(22)5-7-17/h4-10,13-14,18,29H,11H2,1-3H3,(H,24,25,26)	IBQFUTIPFZCCSX-UHFFFAOYSA-N	247630	US9688672, Example 232::US9434719, 232 as TFA salt::US10112931, Example 232	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 26.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247630&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451990	346542170							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564887	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cnc(s2)-c2ccccn2)n1 |r|	InChI=1S/C19H19ClN6O3S/c1-10(14-8-22-17(30-14)12-5-3-4-6-21-12)23-18-24-15(20)7-16(25-18)26-13(11(2)27)9-29-19(26)28/h3-8,10-11,13,27H,9H2,1-2H3,(H,23,24,25)	XGBORLPZEYFPOL-UHFFFAOYSA-N	247631	US9688672, Example 233::US9434719, 233 as TFA salt::US10112931, Example 233	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 377					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247631&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451986	346542171							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564888	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cnc(s2)-c2cccnc2)n1 |r|	InChI=1S/C19H19ClN6O3S/c1-10(14-8-22-17(30-14)12-4-3-5-21-7-12)23-18-24-15(20)6-16(25-18)26-13(11(2)27)9-29-19(26)28/h3-8,10-11,13,27H,9H2,1-2H3,(H,23,24,25)	GWNOCTRCIHVVOY-UHFFFAOYSA-N	247632	US9688672, Example 234::US9434719, 234 as TFA salt::US10112931, Example 234	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 213					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247632&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451987	346542172							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564889	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cnc(s2)-c2ccncc2)n1 |r|	InChI=1S/C19H19ClN6O3S/c1-10(14-8-22-17(30-14)12-3-5-21-6-4-12)23-18-24-15(20)7-16(25-18)26-13(11(2)27)9-29-19(26)28/h3-8,10-11,13,27H,9H2,1-2H3,(H,23,24,25)	IROXAHIFHVMTEB-UHFFFAOYSA-N	247633	US9688672, Example 235::US9434719, 235 as TFA salt::US10112931, Example 235	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 964					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247633&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451988	346542173							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564890	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H22ClN5O4/c1-11-8-19(27-17(13(3)28)10-30-21(27)29)25-20(23-11)24-12(2)16-9-18(31-26-16)14-4-6-15(22)7-5-14/h4-9,12-13,17,28H,10H2,1-3H3,(H,23,24,25)	FPLYMOMTXHDUGW-UHFFFAOYSA-N	247634	US9688672, Example 236::US9434719, 236 as TFA salt::US10112931, Example 236	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 24.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247634&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269414	346542174							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564891	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H22ClN5O4/c1-11-8-19(27-17(13(3)28)10-30-21(27)29)25-20(23-11)24-12(2)16-9-18(31-26-16)14-4-6-15(22)7-5-14/h4-9,12-13,17,28H,10H2,1-3H3,(H,23,24,25)	FPLYMOMTXHDUGW-UHFFFAOYSA-N	247634	US9688672, Example 236::US9434719, 236 as TFA salt::US10112931, Example 236	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 23.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247634&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269414	346542174							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564892	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H22ClN5O3S/c1-11-8-18(27-16(13(3)28)10-30-21(27)29)26-20(24-11)25-12(2)17-9-23-19(31-17)14-4-6-15(22)7-5-14/h4-9,12-13,16,28H,10H2,1-3H3,(H,24,25,26)	ZOKITBNIUWKILT-UHFFFAOYSA-N	247635	US9688672, Example 237::US9434719, 237 as TFA salt::US10112931, Example 237	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247635&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269415	346542175							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564893	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H22ClN5O3S/c1-11-8-18(27-16(13(3)28)10-30-21(27)29)26-20(24-11)25-12(2)17-9-23-19(31-17)14-4-6-15(22)7-5-14/h4-9,12-13,16,28H,10H2,1-3H3,(H,24,25,26)	ZOKITBNIUWKILT-UHFFFAOYSA-N	247635	US9688672, Example 237::US9434719, 237 as TFA salt::US10112931, Example 237	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 13.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247635&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269415	346542175							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564894	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H23ClN6O3/c1-12-8-19(28-18(14(3)29)10-31-21(28)30)26-20(24-12)25-13(2)17-9-27(11-23-17)16-6-4-15(22)5-7-16/h4-9,11,13-14,18,29H,10H2,1-3H3,(H,24,25,26)	HECWSALEDFQPTC-UHFFFAOYSA-N	247636	US9688672, Example 238::US9434719, 238 as TFA salt::US10112931, Example 238	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247636&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269416	346542176							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564895	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H23ClN6O3/c1-12-8-19(28-18(14(3)29)10-31-21(28)30)26-20(24-12)25-13(2)17-9-27(11-23-17)16-6-4-15(22)5-7-16/h4-9,11,13-14,18,29H,10H2,1-3H3,(H,24,25,26)	HECWSALEDFQPTC-UHFFFAOYSA-N	247636	US9688672, Example 238::US9434719, 238 as TFA salt::US10112931, Example 238	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247636&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269416	346542176							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564896	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2nc(no2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H21ClN6O4/c1-10-8-16(27-15(12(3)28)9-30-20(27)29)24-19(22-10)23-11(2)18-25-17(26-31-18)13-4-6-14(21)7-5-13/h4-8,11-12,15,28H,9H2,1-3H3,(H,22,23,24)	UFZIIKCLHDLDOA-UHFFFAOYSA-N	247637	US9688672, Example 239::US9434719, 239 as TFA salt::US10112931, Example 239	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 49.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247637&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451991	346542177							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564897	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2nc(no2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H21ClN6O4/c1-10-8-16(27-15(12(3)28)9-30-20(27)29)24-19(22-10)23-11(2)18-25-17(26-31-18)13-4-6-14(21)7-5-13/h4-8,11-12,15,28H,9H2,1-3H3,(H,22,23,24)	UFZIIKCLHDLDOA-UHFFFAOYSA-N	247637	US9688672, Example 239::US9434719, 239 as TFA salt::US10112931, Example 239	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247637&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451991	346542177							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564898	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2ccn(n2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H23ClN6O3/c1-12-10-19(28-18(14(3)29)11-31-21(28)30)25-20(23-12)24-13(2)17-8-9-27(26-17)16-6-4-15(22)5-7-16/h4-10,13-14,18,29H,11H2,1-3H3,(H,23,24,25)	ZORATSZUVFSTGC-UHFFFAOYSA-N	247638	US9688672, Example 240::US9434719, 240 as TFA salt::US10112931, Example 240	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 142					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247638&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451989	346542178							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564899	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2ccn(n2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H23ClN6O3/c1-12-10-19(28-18(14(3)29)11-31-21(28)30)25-20(23-12)24-13(2)17-8-9-27(26-17)16-6-4-15(22)5-7-16/h4-10,13-14,18,29H,11H2,1-3H3,(H,23,24,25)	ZORATSZUVFSTGC-UHFFFAOYSA-N	247638	US9688672, Example 240::US9434719, 240 as TFA salt::US10112931, Example 240	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 67.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247638&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451989	346542178							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564900	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2cn(nn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H22ClN7O3/c1-11-8-18(28-17(13(3)29)10-31-20(28)30)24-19(22-11)23-12(2)16-9-27(26-25-16)15-6-4-14(21)5-7-15/h4-9,12-13,17,29H,10H2,1-3H3,(H,22,23,24)	IDFAFGSODHNRAE-UHFFFAOYSA-N	247639	US9688672, Example 241::US9434719, 241 as TFA salt::US10112931, Example 241	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 114					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247639&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452008	346542179							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564901	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2cn(nn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H22ClN7O3/c1-11-8-18(28-17(13(3)29)10-31-20(28)30)24-19(22-11)23-12(2)16-9-27(26-25-16)15-6-4-14(21)5-7-15/h4-9,12-13,17,29H,10H2,1-3H3,(H,22,23,24)	IDFAFGSODHNRAE-UHFFFAOYSA-N	247639	US9688672, Example 241::US9434719, 241 as TFA salt::US10112931, Example 241	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 157					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247639&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452008	346542179							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564902	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cn(nn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C19H19Cl2N7O3/c1-10(14-8-27(26-25-14)13-5-3-12(20)4-6-13)22-18-23-16(21)7-17(24-18)28-15(11(2)29)9-31-19(28)30/h3-8,10-11,15,29H,9H2,1-2H3,(H,22,23,24)	MVNFRIVYALUSNC-UHFFFAOYSA-N	247640	US9688672, Example 242::US9434719, 242 as TFA salt::US10112931, Example 242	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 42.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247640&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451996	346542180							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564903	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cn(nn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C19H19Cl2N7O3/c1-10(14-8-27(26-25-14)13-5-3-12(20)4-6-13)22-18-23-16(21)7-17(24-18)28-15(11(2)29)9-31-19(28)30/h3-8,10-11,15,29H,9H2,1-2H3,(H,22,23,24)	MVNFRIVYALUSNC-UHFFFAOYSA-N	247640	US9688672, Example 242::US9434719, 242 as TFA salt::US10112931, Example 242	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 53.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247640&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451996	346542180							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564904	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(nn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C19H20ClN7O3/c1-11(15-9-26(25-24-15)14-5-3-13(20)4-6-14)22-18-21-8-7-17(23-18)27-16(12(2)28)10-30-19(27)29/h3-9,11-12,16,28H,10H2,1-2H3,(H,21,22,23)	YMPRBDSLBVYVDN-UHFFFAOYSA-N	247641	US9688672, Example 243::US9434719, 243 as TFA salt::US10112931, Example 243	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 141					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247641&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452006	346542181							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564905	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(nn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C19H20ClN7O3/c1-11(15-9-26(25-24-15)14-5-3-13(20)4-6-14)22-18-21-8-7-17(23-18)27-16(12(2)28)10-30-19(27)29/h3-9,11-12,16,28H,10H2,1-2H3,(H,21,22,23)	YMPRBDSLBVYVDN-UHFFFAOYSA-N	247641	US9688672, Example 243::US9434719, 243 as TFA salt::US10112931, Example 243	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 172					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247641&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452006	346542181							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564906	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2ccc(cc2F)C(C)(F)F)n1 |r|	InChI=1S/C20H23F3N4O3/c1-10-7-17(27-16(12(3)28)9-30-19(27)29)26-18(24-10)25-11(2)14-6-5-13(8-15(14)21)20(4,22)23/h5-8,11-12,16,28H,9H2,1-4H3,(H,24,25,26)	MFKGBSTYHGRYAC-UHFFFAOYSA-N	247642	US9688672, Example 244::US9434719, 244 as TFA salt::US10112931, Example 244	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 300					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247642&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452007	346542182							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564907	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2cc(F)c(OCC(F)(F)F)cc2F)n1 |r|	InChI=1S/C20H21F5N4O4/c1-9-4-17(29-15(11(3)30)7-32-19(29)31)28-18(26-9)27-10(2)12-5-14(22)16(6-13(12)21)33-8-20(23,24)25/h4-6,10-11,15,30H,7-8H2,1-3H3,(H,26,27,28)	HLWUMVHBOXMUDW-UHFFFAOYSA-N	247643	US9688672, Example 245::US9434719, 245 as TFA salt::US10112931, Example 245	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 115					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247643&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452009	346542183							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564908	C[C@@H](O)[C@H]1COC(=O)N1c1cc(C)nc(N[C@@H](C)c2cnc(s2)-c2ccc(C)nc2)n1 |r|	InChI=1S/C21H24N6O3S/c1-11-5-6-15(8-22-11)19-23-9-17(31-19)13(3)25-20-24-12(2)7-18(26-20)27-16(14(4)28)10-30-21(27)29/h5-9,13-14,16,28H,10H2,1-4H3,(H,24,25,26)	ZJUXDIOBFVYEMM-UHFFFAOYSA-N	247644	US9688672, Example 246::US9434719, 246 as TFA salt::US10112931, Example 246	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 273					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247644&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452001	346542184							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564909	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(nc2)C(F)(F)F)n1 |r|	InChI=1S/C20H19F3N6O3S/c1-10(14-8-26-17(33-14)12-3-4-15(25-7-12)20(21,22)23)27-18-24-6-5-16(28-18)29-13(11(2)30)9-32-19(29)31/h3-8,10-11,13,30H,9H2,1-2H3,(H,24,27,28)	YOXVWMIYZJNANU-UHFFFAOYSA-N	247645	US9688672, Example 247::US9434719, 247 as TFA salt::US10112931, Example 247	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 79.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247645&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451999	346542185							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564910	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C20H19F3N6O3S/c1-10(14-8-26-17(33-14)12-3-5-24-15(7-12)20(21,22)23)27-18-25-6-4-16(28-18)29-13(11(2)30)9-32-19(29)31/h3-8,10-11,13,30H,9H2,1-2H3,(H,25,27,28)	CUGAITRVORLYKS-UHFFFAOYSA-N	247646	US9688672, Example 248::US9434719, 248 as TFA salt::US10112931, Example 248	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 172					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247646&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90451998	346542186							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564911	COC(=O)c1cc(nc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1)N1[C@H](COC1=O)[C@@H](C)O |r|	InChI=1S/C22H22ClN5O5S/c1-11(17-9-24-19(34-17)13-4-6-14(23)7-5-13)25-21-26-15(20(30)32-3)8-18(27-21)28-16(12(2)29)10-33-22(28)31/h4-9,11-12,16,29H,10H2,1-3H3,(H,25,26,27)	RTOYWSLPXKHJCU-UHFFFAOYSA-N	247647	US9688672, Example 249::US9434719, 249 as TFA salt::US10112931, Example 249	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 635					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247647&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452000	346542187							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564912	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(c(C)n2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H23ClN6O3/c1-12(17-10-27(14(3)25-17)16-6-4-15(22)5-7-16)24-20-23-9-8-19(26-20)28-18(13(2)29)11-31-21(28)30/h4-10,12-13,18,29H,11H2,1-3H3,(H,23,24,26)	YPKNXPWEMZFDTH-UHFFFAOYSA-N	247648	US9688672, Example 250::US9434719, 250 as TFA salt::US10112931, Example 250	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 25.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247648&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452002	346542188							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564913	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(cc2)C(F)F)n1 |r|	InChI=1S/C21H21F2N5O3S/c1-11(16-9-25-19(32-16)14-5-3-13(4-6-14)18(22)23)26-20-24-8-7-17(27-20)28-15(12(2)29)10-31-21(28)30/h3-9,11-12,15,18,29H,10H2,1-2H3,(H,24,26,27)	OZBMOMJUPQEKSW-UHFFFAOYSA-N	247649	US9688672, Example 251::US9434719, 251 as TFA salt::US10112931, Example 251	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247649&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269417	346542189							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564914	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cc2F)C(F)(F)F)n1 |r|	InChI=1S/C18H18F4N4O3/c1-9(12-4-3-11(7-13(12)19)18(20,21)22)24-16-23-6-5-15(25-16)26-14(10(2)27)8-29-17(26)28/h3-7,9-10,14,27H,8H2,1-2H3,(H,23,24,25)	RYHKACMYIHVDLT-UHFFFAOYSA-N	247650	US9688672, Example 252::US9434719, 252 as TFA salt::US10112931, Example 252	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 309					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247650&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452010	346542190							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564915	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cc2F)C(F)(F)F)n1 |r|	InChI=1S/C18H18F4N4O3/c1-9(12-4-3-11(7-13(12)19)18(20,21)22)24-16-23-6-5-15(25-16)26-14(10(2)27)8-29-17(26)28/h3-7,9-10,14,27H,8H2,1-2H3,(H,23,24,25)	RYHKACMYIHVDLT-UHFFFAOYSA-N	247650	US9688672, Example 252::US9434719, 252 as TFA salt::US10112931, Example 252	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 353					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247650&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452010	346542190							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564916	CCOC1(CC1)c1ccc([C@H](C)Nc2nccc(n2)N2[C@H](COC2=O)[C@@H](C)O)c(F)c1 |r|	InChI=1S/C22H27FN4O4/c1-4-31-22(8-9-22)15-5-6-16(17(23)11-15)13(2)25-20-24-10-7-19(26-20)27-18(14(3)28)12-30-21(27)29/h5-7,10-11,13-14,18,28H,4,8-9,12H2,1-3H3,(H,24,25,26)	AQYCAWIUYRMHIB-UHFFFAOYSA-N	247651	US9688672, Example 253::US9434719, 253 as TFA salt::US10112931, Example 253	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 109					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247651&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452005	346542191							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564917	CCOC1(CC1)c1ccc([C@H](C)Nc2nccc(n2)N2[C@H](COC2=O)[C@@H](C)O)c(F)c1 |r|	InChI=1S/C22H27FN4O4/c1-4-31-22(8-9-22)15-5-6-16(17(23)11-15)13(2)25-20-24-10-7-19(26-20)27-18(14(3)28)12-30-21(27)29/h5-7,10-11,13-14,18,28H,4,8-9,12H2,1-3H3,(H,24,25,26)	AQYCAWIUYRMHIB-UHFFFAOYSA-N	247651	US9688672, Example 253::US9434719, 253 as TFA salt::US10112931, Example 253	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 121					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247651&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452005	346542191							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564918	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(C(=O)NC3CCCC3)c(Cl)c2)n1 |r|	InChI=1S/C23H28ClN5O4/c1-13(15-7-8-17(18(24)11-15)21(31)27-16-5-3-4-6-16)26-22-25-10-9-20(28-22)29-19(14(2)30)12-33-23(29)32/h7-11,13-14,16,19,30H,3-6,12H2,1-2H3,(H,27,31)(H,25,26,28)	XRZIQGOJIJWMMV-UHFFFAOYSA-N	247652	US9688672, Example 254::US9434719, 254 as TFA salt::US10112931, Example 254	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 234					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247652&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454395	346542192							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564919	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cc2F)C2(CC2)C#N)n1 |r|	InChI=1S/C21H22FN5O3/c1-12(15-4-3-14(9-16(15)22)21(11-23)6-7-21)25-19-24-8-5-18(26-19)27-17(13(2)28)10-30-20(27)29/h3-5,8-9,12-13,17,28H,6-7,10H2,1-2H3,(H,24,25,26)	QBZLIKUJCVQCBW-UHFFFAOYSA-N	247653	US9688672, Example 255::US9434719, 255 as TFA salt::US10112931, Example 255	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 450					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247653	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247653&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452003	346542193							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564920	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cc2F)-c2cnn(C)c2)n1 |r|	InChI=1S/C21H23FN6O3/c1-12(16-5-4-14(8-17(16)22)15-9-24-27(3)10-15)25-20-23-7-6-19(26-20)28-18(13(2)29)11-31-21(28)30/h4-10,12-13,18,29H,11H2,1-3H3,(H,23,25,26)	GHQLTKCUTUVNJO-UHFFFAOYSA-N	247654	US9688672, Example 256::US9434719, 256 as TFA salt::US10112931, Example 256	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 570					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247654&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452015	346542194							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564921	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cc2F)-c2cnn(C)c2)n1 |r|	InChI=1S/C21H23FN6O3/c1-12(16-5-4-14(8-17(16)22)15-9-24-27(3)10-15)25-20-23-7-6-19(26-20)28-18(13(2)29)11-31-21(28)30/h4-10,12-13,18,29H,11H2,1-3H3,(H,23,25,26)	GHQLTKCUTUVNJO-UHFFFAOYSA-N	247654	US9688672, Example 256::US9434719, 256 as TFA salt::US10112931, Example 256	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 489					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247654&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452015	346542194							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564922	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cc2)-c2cnn(C)c2)n1 |r|	InChI=1S/C21H24N6O3/c1-13(15-4-6-16(7-5-15)17-10-23-26(3)11-17)24-20-22-9-8-19(25-20)27-18(14(2)28)12-30-21(27)29/h4-11,13-14,18,28H,12H2,1-3H3,(H,22,24,25)	ZHQOAULHCPIAQO-UHFFFAOYSA-N	247655	US9688672, Example 257::US9434719, 257 as TFA salt::US10112931, Example 257	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1200					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247655	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247655&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452017	346542195							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564923	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cc2F)-c2cn[nH]c2)n1 |r|	InChI=1S/C20H21FN6O3/c1-11(15-4-3-13(7-16(15)21)14-8-23-24-9-14)25-19-22-6-5-18(26-19)27-17(12(2)28)10-30-20(27)29/h3-9,11-12,17,28H,10H2,1-2H3,(H,23,24)(H,22,25,26)	WRVBZZKIFIZKOM-UHFFFAOYSA-N	247656	US9688672, Example 258::US9434719, 258 as TFA salt::US10112931, Example 258	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 737					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247656	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247656&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452011	346542196							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564924	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cc2F)-c2cn[nH]c2)n1 |r|	InChI=1S/C20H21FN6O3/c1-11(15-4-3-13(7-16(15)21)14-8-23-24-9-14)25-19-22-6-5-18(26-19)27-17(12(2)28)10-30-20(27)29/h3-9,11-12,17,28H,10H2,1-2H3,(H,23,24)(H,22,25,26)	WRVBZZKIFIZKOM-UHFFFAOYSA-N	247656	US9688672, Example 258::US9434719, 258 as TFA salt::US10112931, Example 258	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 435					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247656	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247656&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452011	346542196							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564925	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)C(F)(F)F)ncc1F |r|	InChI=1S/C18H17F5N4O3/c1-8(11-4-3-10(5-12(11)19)18(21,22)23)25-16-24-6-13(20)15(26-16)27-14(9(2)28)7-30-17(27)29/h3-6,8-9,14,28H,7H2,1-2H3,(H,24,25,26)	PEBYCAUAWFUTMN-UHFFFAOYSA-N	247657	US9688672, Example 259::US9434719, 259::US10112931, Example 259	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 105					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247657&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452004	346542197							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564926	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)C(F)(F)F)ncc1F |r|	InChI=1S/C18H17F5N4O3/c1-8(11-4-3-10(5-12(11)19)18(21,22)23)25-16-24-6-13(20)15(26-16)27-14(9(2)28)7-30-17(27)29/h3-6,8-9,14,28H,7H2,1-2H3,(H,24,25,26)	PEBYCAUAWFUTMN-UHFFFAOYSA-N	247657	US9688672, Example 259::US9434719, 259::US10112931, Example 259	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 103					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247657&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452004	346542197							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564927	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)C(F)(F)F)ncc1F |r|	InChI=1S/C18H17F5N4O3/c1-8(11-4-3-10(5-12(11)19)18(21,22)23)25-16-24-6-13(20)15(26-16)27-14(9(2)28)7-30-17(27)29/h3-6,8-9,14,28H,7H2,1-2H3,(H,24,25,26)	PEBYCAUAWFUTMN-UHFFFAOYSA-N	247657	US9688672, Example 259::US9434719, 259::US10112931, Example 259	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 49.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247657&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452004	346542197							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564928	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cc2F)C2(C)CC2)n1 |r|	InChI=1S/C21H25FN4O3/c1-12(15-5-4-14(10-16(15)22)21(3)7-8-21)24-19-23-9-6-18(25-19)26-17(13(2)27)11-29-20(26)28/h4-6,9-10,12-13,17,27H,7-8,11H2,1-3H3,(H,23,24,25)	IOJOVSUDBXKRLR-UHFFFAOYSA-N	247658	US9688672, Example 260::US9434719, 260 as TFA salt::US10112931, Example 260	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 40.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247658	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247658&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269623	346542198							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564929	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cc2F)C2(C)CC2)n1 |r|	InChI=1S/C21H25FN4O3/c1-12(15-5-4-14(10-16(15)22)21(3)7-8-21)24-19-23-9-6-18(25-19)26-17(13(2)27)11-29-20(26)28/h4-6,9-10,12-13,17,27H,7-8,11H2,1-3H3,(H,23,24,25)	IOJOVSUDBXKRLR-UHFFFAOYSA-N	247658	US9688672, Example 260::US9434719, 260 as TFA salt::US10112931, Example 260	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 39.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247658	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247658&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269623	346542198							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564930	CC(C)c1ccc([C@H](C)Nc2nccc(n2)N2[C@H](COC2=O)[C@@H](C)O)c(F)c1 |r|	InChI=1S/C20H25FN4O3/c1-11(2)14-5-6-15(16(21)9-14)12(3)23-19-22-8-7-18(24-19)25-17(13(4)26)10-28-20(25)27/h5-9,11-13,17,26H,10H2,1-4H3,(H,22,23,24)	CDQINWYQTPTUKW-UHFFFAOYSA-N	247659	US9688672, Example 261::US9434719, 261 as TFA salt::US10112931, Example 261	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 64.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247659&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452012	346542199							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564931	CC(C)c1ccc([C@H](C)Nc2nccc(n2)N2[C@H](COC2=O)[C@@H](C)O)c(F)c1 |r|	InChI=1S/C20H25FN4O3/c1-11(2)14-5-6-15(16(21)9-14)12(3)23-19-22-8-7-18(24-19)25-17(13(4)26)10-28-20(25)27/h5-9,11-13,17,26H,10H2,1-4H3,(H,22,23,24)	CDQINWYQTPTUKW-UHFFFAOYSA-N	247659	US9688672, Example 261::US9434719, 261 as TFA salt::US10112931, Example 261	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 89.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247659&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452012	346542199							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564932	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)-c2cnn(C)c2)ncc1F |r|	InChI=1S/C21H22F2N6O3/c1-11(15-5-4-13(6-16(15)22)14-7-25-28(3)9-14)26-20-24-8-17(23)19(27-20)29-18(12(2)30)10-32-21(29)31/h4-9,11-12,18,30H,10H2,1-3H3,(H,24,26,27)	TXAUZBVLXHFROM-UHFFFAOYSA-N	247660	US9688672, Example 262::US9434719, 262 as TFA salt::US10112931, Example 262	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 88.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247660	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247660&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118121698	346542200							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564933	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)-c2cnn(C)c2)ncc1F |r|	InChI=1S/C21H22F2N6O3/c1-11(15-5-4-13(6-16(15)22)14-7-25-28(3)9-14)26-20-24-8-17(23)19(27-20)29-18(12(2)30)10-32-21(29)31/h4-9,11-12,18,30H,10H2,1-3H3,(H,24,26,27)	TXAUZBVLXHFROM-UHFFFAOYSA-N	247660	US9688672, Example 262::US9434719, 262 as TFA salt::US10112931, Example 262	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 167					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247660	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247660&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118121698	346542200							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564934	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)C2(C)CC2)ncc1F |r|	InChI=1S/C21H24F2N4O3/c1-11(14-5-4-13(8-15(14)22)21(3)6-7-21)25-19-24-9-16(23)18(26-19)27-17(12(2)28)10-30-20(27)29/h4-5,8-9,11-12,17,28H,6-7,10H2,1-3H3,(H,24,25,26)	MGAMZOLBMBPWEM-UHFFFAOYSA-N	247661	US9688672, Example 263::US9434719, 263 as TFA salt::US10112931, Example 263	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247661&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452024	346542201							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564935	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)-c2cn[nH]c2)ncc1F |r|	InChI=1S/C20H20F2N6O3/c1-10(14-4-3-12(5-15(14)21)13-6-24-25-7-13)26-19-23-8-16(22)18(27-19)28-17(11(2)29)9-31-20(28)30/h3-8,10-11,17,29H,9H2,1-2H3,(H,24,25)(H,23,26,27)	ZSTVKHUONQKLGP-UHFFFAOYSA-N	247662	US9688672, Example 264::US9434719, 264 as TFA salt::US10112931, Example 264	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 152					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247662	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247662&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452013	346542202							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564936	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)-c2cn[nH]c2)ncc1F |r|	InChI=1S/C20H20F2N6O3/c1-10(14-4-3-12(5-15(14)21)13-6-24-25-7-13)26-19-23-8-16(22)18(27-19)28-17(11(2)29)9-31-20(28)30/h3-8,10-11,17,29H,9H2,1-2H3,(H,24,25)(H,23,26,27)	ZSTVKHUONQKLGP-UHFFFAOYSA-N	247662	US9688672, Example 264::US9434719, 264 as TFA salt::US10112931, Example 264	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 249					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247662	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247662&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452013	346542202							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564937	CC(C)c1ccc([C@H](C)Nc2ncc(F)c(n2)N2[C@H](COC2=O)[C@@H](C)O)c(F)c1 |r|	InChI=1S/C20H24F2N4O3/c1-10(2)13-5-6-14(15(21)7-13)11(3)24-19-23-8-16(22)18(25-19)26-17(12(4)27)9-29-20(26)28/h5-8,10-12,17,27H,9H2,1-4H3,(H,23,24,25)	UQVMWOQOFJPWHK-UHFFFAOYSA-N	247663	US9434719, 265 as TFA salt::US10112931, Example 265	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 36.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247663	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247663&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452014	346542203							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564938	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)C(C)(C)O)ncc1F |r|	InChI=1S/C20H24F2N4O4/c1-10(13-6-5-12(7-14(13)21)20(3,4)29)24-18-23-8-15(22)17(25-18)26-16(11(2)27)9-30-19(26)28/h5-8,10-11,16,27,29H,9H2,1-4H3,(H,23,24,25)	MGUKRKGLGOTAFE-UHFFFAOYSA-N	247664	US9688672, Example 266::US9434719, 266 as TFA salt::US10112931, Example 266	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 453					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247664	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247664&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452016	346542204							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564939	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(F)c(cc2F)-c2cnn(C)c2)ncc1F |r|	InChI=1S/C21H21F3N6O3/c1-10(13-4-16(23)14(5-15(13)22)12-6-26-29(3)8-12)27-20-25-7-17(24)19(28-20)30-18(11(2)31)9-33-21(30)32/h4-8,10-11,18,31H,9H2,1-3H3,(H,25,27,28)	IOWKGSVTZWXRBF-UHFFFAOYSA-N	247665	US9688672, Example 267::US9434719, 267 as TFA salt::US10112931, Example 267	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 48.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247665	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247665&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452019	346542205							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564940	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(F)c(cc2F)-c2cnn(C)c2)ncc1F |r|	InChI=1S/C21H21F3N6O3/c1-10(13-4-16(23)14(5-15(13)22)12-6-26-29(3)8-12)27-20-25-7-17(24)19(28-20)30-18(11(2)31)9-33-21(30)32/h4-8,10-11,18,31H,9H2,1-3H3,(H,25,27,28)	IOWKGSVTZWXRBF-UHFFFAOYSA-N	247665	US9688672, Example 267::US9434719, 267 as TFA salt::US10112931, Example 267	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 95.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247665	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247665&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452019	346542205							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564941	C[C@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClN5O3S/c1-11(16-9-23-18(30-16)13-3-5-14(21)6-4-13)24-19-22-8-7-17(25-19)26-15(12(2)27)10-29-20(26)28/h3-9,11-12,15,27H,10H2,1-2H3,(H,22,24,25)	GVHVMKBUEILJFX-UHFFFAOYSA-N	247666	US9688672, Example 268::US9434719, 268 as TFA salt::US10112931, Example 268	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 338					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247666	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247666&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414838	346542206							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564942	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(cc2F)C(C)(C)F)n1 |r|	InChI=1S/C20H23ClF2N4O3/c1-10(13-6-5-12(7-14(13)22)20(3,4)23)24-18-25-16(21)8-17(26-18)27-15(11(2)28)9-30-19(27)29/h5-8,10-11,15,28H,9H2,1-4H3,(H,24,25,26)	YUIMGYKEBSSANY-UHFFFAOYSA-N	247667	US9688672, Example 269::US9434719, 269::US10112931, Example 269	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 251					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247667	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247667&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452021	346542207							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564943	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)ncc1Cl |r|	InChI=1S/C20H20Cl2N6O3/c1-11(16-8-27(10-24-16)14-5-3-13(21)4-6-14)25-19-23-7-15(22)18(26-19)28-17(12(2)29)9-31-20(28)30/h3-8,10-12,17,29H,9H2,1-2H3,(H,23,25,26)	MFAIVUGSMBNZNQ-UHFFFAOYSA-N	247668	US9688672, Example 270::US9434719, 270 as TFA salt::US10112931, Example 270	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 174					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247668	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247668&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452018	346542208							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564944	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)ncc1Cl |r|	InChI=1S/C20H20Cl2N6O3/c1-11(16-8-27(10-24-16)14-5-3-13(21)4-6-14)25-19-23-7-15(22)18(26-19)28-17(12(2)29)9-31-20(28)30/h3-8,10-12,17,29H,9H2,1-2H3,(H,23,25,26)	MFAIVUGSMBNZNQ-UHFFFAOYSA-N	247668	US9688672, Example 270::US9434719, 270 as TFA salt::US10112931, Example 270	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 163					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247668	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247668&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452018	346542208							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564945	CC(C)c1cc(F)c(cc1F)[C@H](C)Nc1nccc(n1)N1[C@H](COC1=O)C(C)O |r|	InChI=1S/C20H24F2N4O3/c1-10(2)13-7-16(22)14(8-15(13)21)11(3)24-19-23-6-5-18(25-19)26-17(12(4)27)9-29-20(26)28/h5-8,10-12,17,27H,9H2,1-4H3,(H,23,24,25)	ZGASCMMHPOSBQL-UHFFFAOYSA-N	247669	US9688672, Example 271::US9434719, 271 as TFA salt::US10112931, Example 271	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 339					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247669	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247669&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452020	346542209							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564946	CC(O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(Br)cc2F)n1 |r|	InChI=1S/C17H17BrF2N4O3/c1-8(10-5-13(20)11(18)6-12(10)19)22-16-21-4-3-15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	NPDKKAHJQMWLIK-UHFFFAOYSA-N	247670	US9688672, Example 272::US9434719, 272 as TFA salt::US10112931, Example 272	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 117					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247670	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247670&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452023	346542210							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564947	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(c(Cl)c2)C(C)(F)F)n1 |r|	InChI=1S/C18H20ClF2N5O3/c1-9(11-6-12(19)15(23-7-11)18(3,20)21)24-16-22-5-4-14(25-16)26-13(10(2)27)8-29-17(26)28/h4-7,9-10,13,27H,8H2,1-3H3,(H,22,24,25)	VGQWNJKQUWZUBN-UHFFFAOYSA-N	247671	US9434719, 273 as TFA salt::US10112931, Example 273	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 585					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247671	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247671&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452025	346542211							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564948	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(OCC(F)(F)F)c(Cl)c2)n1 |r|	InChI=1S/C18H19ClF3N5O4/c1-9(11-5-12(19)15(24-6-11)31-8-18(20,21)22)25-16-23-4-3-14(26-16)27-13(10(2)28)7-30-17(27)29/h3-6,9-10,13,28H,7-8H2,1-2H3,(H,23,25,26)	SRPTYBWYKYVGBT-UHFFFAOYSA-N	247672	US9434719, 274 as TFA salt::US10112931, Example 274	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 265					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247672	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247672&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452026	346542212							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564949	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(Br)c(F)c2F)n1 |r|	InChI=1S/C17H17BrF2N4O3/c1-8(10-3-4-11(18)15(20)14(10)19)22-16-21-6-5-13(23-16)24-12(9(2)25)7-27-17(24)26/h3-6,8-9,12,25H,7H2,1-2H3,(H,21,22,23)	RTMNGYGISOLNCX-UHFFFAOYSA-N	247673	US9434719, 275 as TFA salt::US10112931, Example 275	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 311					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247673	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247673&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452027	346542213							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564950	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(F)c(Br)cc2F)ncc1F |r|	InChI=1S/C17H16BrF3N4O3/c1-7(9-3-12(20)10(18)4-11(9)19)23-16-22-5-13(21)15(24-16)25-14(8(2)26)6-28-17(25)27/h3-5,7-8,14,26H,6H2,1-2H3,(H,22,23,24)	XICFZWGQSFTILV-UHFFFAOYSA-N	247674	US9434719, 276 as TFA salt::US10112931, Example 276	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 51.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247674	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247674&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452028	346542214							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564951	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Cl)cc2F)ncc1F |r|	InChI=1S/C17H17ClF2N4O3/c1-8(11-4-3-10(18)5-12(11)19)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	MIKNJCHRGQEDCS-UHFFFAOYSA-N	247675	US9688672, Example 278::US9434719, 278 as TFA salt::US9434719, 277 as TFA salt::US10112931, Example 278	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 86.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247675	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247675&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452029	346542215							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564952	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Cl)cc2F)ncc1F |r|	InChI=1S/C17H17ClF2N4O3/c1-8(11-4-3-10(18)5-12(11)19)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	MIKNJCHRGQEDCS-UHFFFAOYSA-N	247675	US9688672, Example 278::US9434719, 278 as TFA salt::US9434719, 277 as TFA salt::US10112931, Example 278	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 174					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247675	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247675&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452029	346542215							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564953	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Cl)cc2F)ncc1F |r|	InChI=1S/C17H17ClF2N4O3/c1-8(11-4-3-10(18)5-12(11)19)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	MIKNJCHRGQEDCS-UHFFFAOYSA-N	247675	US9688672, Example 278::US9434719, 278 as TFA salt::US9434719, 277 as TFA salt::US10112931, Example 278	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 163					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247675	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247675&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452029	346542215							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564954	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ncc(Br)cc2F)ncc1F |r|	InChI=1S/C16H16BrF2N5O3/c1-7(13-10(18)3-9(17)4-20-13)22-15-21-5-11(19)14(23-15)24-12(8(2)25)6-27-16(24)26/h3-5,7-8,12,25H,6H2,1-2H3,(H,21,22,23)	YTKUKOMQKYDZGC-UHFFFAOYSA-N	247677	US9688672, Example 279::US9434719, 279 as TFA salt::US10112931, Example 279	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12700					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247677	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247677&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452030	346542216							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564955	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@H](C)c2ncc(Br)cc2F)ncc1F |r|	InChI=1S/C16H16BrF2N5O3/c1-7(13-10(18)3-9(17)4-20-13)22-15-21-5-11(19)14(23-15)24-12(8(2)25)6-27-16(24)26/h3-5,7-8,12,25H,6H2,1-2H3,(H,21,22,23)	YTKUKOMQKYDZGC-UHFFFAOYSA-N	247678	US9688672, Example 280::US9434719, 280 as TFA salt::US10112931, Example 280	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3640					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247678	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247678&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452031	346542217							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564956	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2nc(no2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C19H18ClFN6O4/c1-9(17-24-15(26-31-17)11-3-5-12(20)6-4-11)23-18-22-7-13(21)16(25-18)27-14(10(2)28)8-30-19(27)29/h3-7,9-10,14,28H,8H2,1-2H3,(H,22,23,25)	PESHRRIJDGTOFK-UHFFFAOYSA-N	247679	US9688672, Example 281::US9434719, 281 as TFA salt::US10112931, Example 281	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 26.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247679	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247679&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452032	346542218							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564957	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2nc(no2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C19H18ClFN6O4/c1-9(17-24-15(26-31-17)11-3-5-12(20)6-4-11)23-18-22-7-13(21)16(25-18)27-14(10(2)28)8-30-19(27)29/h3-7,9-10,14,28H,8H2,1-2H3,(H,22,23,25)	PESHRRIJDGTOFK-UHFFFAOYSA-N	247679	US9688672, Example 281::US9434719, 281 as TFA salt::US10112931, Example 281	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 64.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247679	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247679&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452032	346542218							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564958	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Br)cn2)ncc1F |r|	InChI=1S/C16H17BrFN5O3/c1-8(12-4-3-10(17)5-19-12)21-15-20-6-11(18)14(22-15)23-13(9(2)24)7-26-16(23)25/h3-6,8-9,13,24H,7H2,1-2H3,(H,20,21,22)	RBAOXXAHDHLUBH-UHFFFAOYSA-N	247680	US9688672, Example 282::US9434719, 282 as TFA salt::US10112931, Example 282	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4270					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247680	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247680&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452034	346542219							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564959	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Br)c(F)c2)ncc1F |r|	InChI=1S/C17H17BrF2N4O3/c1-8(10-3-4-11(18)12(19)5-10)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	WTPORLYMZRGTMX-UHFFFAOYSA-N	247681	US9688672, Example 283::US9434719, 283 as TFA salt::US10112931, Example 283	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 68.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247681	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247681&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452035	346542220							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564960	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Br)c(F)c2)ncc1F |r|	InChI=1S/C17H17BrF2N4O3/c1-8(10-3-4-11(18)12(19)5-10)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	WTPORLYMZRGTMX-UHFFFAOYSA-N	247681	US9688672, Example 283::US9434719, 283 as TFA salt::US10112931, Example 283	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 248					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247681	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247681&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452035	346542220							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564961	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnc(c(Cl)c2)C(C)(F)F)ncc1F |r|	InChI=1S/C18H19ClF3N5O3/c1-8(10-4-11(19)14(23-5-10)18(3,21)22)25-16-24-6-12(20)15(26-16)27-13(9(2)28)7-30-17(27)29/h4-6,8-9,13,28H,7H2,1-3H3,(H,24,25,26)	FXEUSGVGTLCLKW-UHFFFAOYSA-N	247682	US9688672, Example 284::US9434719, 284 as TFA salt::US10112931, Example 284	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 266					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247682	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247682&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452033	346542221							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564962	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnc(OCC(F)(F)F)c(Cl)c2)ncc1F |r|	InChI=1S/C18H18ClF4N5O4/c1-8(10-3-11(19)15(24-4-10)32-7-18(21,22)23)26-16-25-5-12(20)14(27-16)28-13(9(2)29)6-31-17(28)30/h3-5,8-9,13,29H,6-7H2,1-2H3,(H,25,26,27)	OGZGYYFXIANBIU-UHFFFAOYSA-N	247683	US9688672, Example 285::US9434719, 285 as TFA salt::US10112931, Example 285	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 53.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247683&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414304	346542222							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564963	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnc(OCC(F)(F)F)c(Cl)c2)ncc1F |r|	InChI=1S/C18H18ClF4N5O4/c1-8(10-3-11(19)15(24-4-10)32-7-18(21,22)23)26-16-25-5-12(20)14(27-16)28-13(9(2)29)6-31-17(28)30/h3-5,8-9,13,29H,6-7H2,1-2H3,(H,25,26,27)	OGZGYYFXIANBIU-UHFFFAOYSA-N	247683	US9688672, Example 285::US9434719, 285 as TFA salt::US10112931, Example 285	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 146					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247683&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414304	346542222							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564964	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Cl)cc2Cl)ncc1F |r|	InChI=1S/C17H17Cl2FN4O3/c1-8(11-4-3-10(18)5-12(11)19)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	CEORPLNBANSUEU-UHFFFAOYSA-N	247684	US9688672, Example 286::US9434719, 286 as TFA salt::US10112931, Example 286	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 36.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247684	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247684&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452036	346542223							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564965	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Cl)cc2Cl)ncc1F |r|	InChI=1S/C17H17Cl2FN4O3/c1-8(11-4-3-10(18)5-12(11)19)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	CEORPLNBANSUEU-UHFFFAOYSA-N	247684	US9688672, Example 286::US9434719, 286 as TFA salt::US10112931, Example 286	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 145					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247684	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247684&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452036	346542223							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564966	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Br)nc2)ncc1F |r|	InChI=1S/C16H17BrFN5O3/c1-8(10-3-4-13(17)19-5-10)21-15-20-6-11(18)14(22-15)23-12(9(2)24)7-26-16(23)25/h3-6,8-9,12,24H,7H2,1-2H3,(H,20,21,22)	UQOZSNMDWKOGKY-UHFFFAOYSA-N	247685	US9688672, Example 287::US9434719, 287 as TFA salt::US10112931, Example 287	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2250					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247685	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247685&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452037	346542224							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564967	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Br)nc2)ncc1F |r|	InChI=1S/C16H17BrFN5O3/c1-8(10-3-4-13(17)19-5-10)21-15-20-6-11(18)14(22-15)23-12(9(2)24)7-26-16(23)25/h3-6,8-9,12,24H,7H2,1-2H3,(H,20,21,22)	UQOZSNMDWKOGKY-UHFFFAOYSA-N	247685	US9688672, Example 287::US9434719, 287 as TFA salt::US10112931, Example 287	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 46301					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247685	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247685&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452037	346542224							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564968	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Cl)c(F)c2)ncc1F |r|	InChI=1S/C17H17ClF2N4O3/c1-8(10-3-4-11(18)12(19)5-10)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	IDOWDLBTGMMLQK-UHFFFAOYSA-N	247686	US9688672, Example 288::US9434719, 288 as TFA salt::US10112931, Example 288	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 55.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247686	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247686&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452039	346542225							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564969	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Cl)c(F)c2)ncc1F |r|	InChI=1S/C17H17ClF2N4O3/c1-8(10-3-4-11(18)12(19)5-10)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	IDOWDLBTGMMLQK-UHFFFAOYSA-N	247686	US9688672, Example 288::US9434719, 288 as TFA salt::US10112931, Example 288	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 178					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247686	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247686&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452039	346542225							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564970	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@H](C)c2ccc(Br)cn2)ncc1F |r|	InChI=1S/C16H17BrFN5O3/c1-8(12-4-3-10(17)5-19-12)21-15-20-6-11(18)14(22-15)23-13(9(2)24)7-26-16(23)25/h3-6,8-9,13,24H,7H2,1-2H3,(H,20,21,22)	RBAOXXAHDHLUBH-UHFFFAOYSA-N	247687	US9688672, Example 289::US9434719, 289 as TFA salt::US10112931, Example 289	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2110					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247687	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247687&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452038	346542226							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564971	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Cl)c(Cl)c2)ncc1F |r|	InChI=1S/C17H17Cl2FN4O3/c1-8(10-3-4-11(18)12(19)5-10)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	WFOPXBRBZHRGKH-UHFFFAOYSA-N	247688	US9688672, Example 290::US9434719, 290 as TFA salt::US10112931, Example 290	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 34.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247688	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247688&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452046	346542227							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564972	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(Cl)c(Cl)c2)ncc1F |r|	InChI=1S/C17H17Cl2FN4O3/c1-8(10-3-4-11(18)12(19)5-10)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	WFOPXBRBZHRGKH-UHFFFAOYSA-N	247688	US9688672, Example 290::US9434719, 290 as TFA salt::US10112931, Example 290	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 53.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247688	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247688&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452046	346542227							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564973	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnc(Cl)c(F)c2)ncc1F |r|	InChI=1S/C16H16ClF2N5O3/c1-7(9-3-10(18)13(17)20-4-9)22-15-21-5-11(19)14(23-15)24-12(8(2)25)6-27-16(24)26/h3-5,7-8,12,25H,6H2,1-2H3,(H,21,22,23)	KFYDKIZAFGPBDT-UHFFFAOYSA-N	247689	US9688672, Example 291::US9434719, 291::US10112931, Example 291	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247689	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247689&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452040	346542228							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564974	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnc(Cl)c(Cl)c2)ncc1F |r|	InChI=1S/C16H16Cl2FN5O3/c1-7(9-3-10(17)13(18)20-4-9)22-15-21-5-11(19)14(23-15)24-12(8(2)25)6-27-16(24)26/h3-5,7-8,12,25H,6H2,1-2H3,(H,21,22,23)	JRULGSSMSCVTFJ-UHFFFAOYSA-N	247690	US9688672, Example 292::US9434719, 292::US10112931, Example 292	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1850					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247690	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247690&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452041	346542229							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564975	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@H](C)c2ncc(Cl)cc2Cl)ncc1F |r|	InChI=1S/C16H16Cl2FN5O3/c1-7(13-10(18)3-9(17)4-20-13)22-15-21-5-11(19)14(23-15)24-12(8(2)25)6-27-16(24)26/h3-5,7-8,12,25H,6H2,1-2H3,(H,21,22,23)	DWCICAAUBMNBFX-UHFFFAOYSA-N	247691	US9688672, Example 293::US9434719, 293::US10112931, Example 293	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>7910					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247691	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247691&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452042	346542230							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564976	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ncc(Cl)cc2Cl)ncc1F |r|	InChI=1S/C16H16Cl2FN5O3/c1-7(13-10(18)3-9(17)4-20-13)22-15-21-5-11(19)14(23-15)24-12(8(2)25)6-27-16(24)26/h3-5,7-8,12,25H,6H2,1-2H3,(H,21,22,23)	DWCICAAUBMNBFX-UHFFFAOYSA-N	247692	US9688672, Example 294::US9434719, 294::US10112931, Example 294	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 466					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247692	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247692&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452045	346542231							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564977	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ncc(Cl)cc2Cl)ncc1F |r|	InChI=1S/C16H16Cl2FN5O3/c1-7(13-10(18)3-9(17)4-20-13)22-15-21-5-11(19)14(23-15)24-12(8(2)25)6-27-16(24)26/h3-5,7-8,12,25H,6H2,1-2H3,(H,21,22,23)	DWCICAAUBMNBFX-UHFFFAOYSA-N	247692	US9688672, Example 294::US9434719, 294::US10112931, Example 294	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 563					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247692	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247692&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452045	346542231							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564978	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ncc(Cl)cc2Cl)n1 |r|	InChI=1S/C16H16Cl3N5O3/c1-7(14-10(18)3-9(17)5-20-14)21-15-22-12(19)4-13(23-15)24-11(8(2)25)6-27-16(24)26/h3-5,7-8,11,25H,6H2,1-2H3,(H,21,22,23)	AGPUBPGXSXBHPI-UHFFFAOYSA-N	247693	US9688672, Example 295::US9434719, 295::US10112931, Example 295	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247693	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247693&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452043	346542232							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564979	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ncc(OCC(F)(F)F)cc2F)n1 |r|	InChI=1S/C18H18ClF4N5O4/c1-8(15-11(20)3-10(5-24-15)32-7-18(21,22)23)25-16-26-13(19)4-14(27-16)28-12(9(2)29)6-31-17(28)30/h3-5,8-9,12,29H,6-7H2,1-2H3,(H,25,26,27)	FJIZBPDEWHMTDE-UHFFFAOYSA-N	247694	US9688672, Example 296::US9434719, 296::US10112931, Example 296	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 251					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247694&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452044	346542233							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564980	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ncc(OCC(F)(F)F)cc2F)n1 |r|	InChI=1S/C18H18ClF4N5O4/c1-8(15-11(20)3-10(5-24-15)32-7-18(21,22)23)25-16-26-13(19)4-14(27-16)28-12(9(2)29)6-31-17(28)30/h3-5,8-9,12,29H,6-7H2,1-2H3,(H,25,26,27)	FJIZBPDEWHMTDE-UHFFFAOYSA-N	247694	US9688672, Example 296::US9434719, 296::US10112931, Example 296	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 277					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247694&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452044	346542233							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564981	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@H](C)c2ccn(n2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H20ClFN6O3/c1-11(16-7-8-27(26-16)14-5-3-13(21)4-6-14)24-19-23-9-15(22)18(25-19)28-17(12(2)29)10-31-20(28)30/h3-9,11-12,17,29H,10H2,1-2H3,(H,23,24,25)	RWUSZRWKGUZDBQ-UHFFFAOYSA-N	247695	US9688672, Example 297::US9434719, 297::US10112931, Example 297	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2960					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247695	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247695&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452047	346542234							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564982	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccn(n2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H20ClFN6O3/c1-11(16-7-8-27(26-16)14-5-3-13(21)4-6-14)24-19-23-9-15(22)18(25-19)28-17(12(2)29)10-31-20(28)30/h3-9,11-12,17,29H,10H2,1-2H3,(H,23,24,25)	RWUSZRWKGUZDBQ-UHFFFAOYSA-N	247696	US9688672, Example 298::US9434719, 298::US10112931, Example 298	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247696&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452048	346542235							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564983	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccn(n2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H20ClFN6O3/c1-11(16-7-8-27(26-16)14-5-3-13(21)4-6-14)24-19-23-9-15(22)18(25-19)28-17(12(2)29)10-31-20(28)30/h3-9,11-12,17,29H,10H2,1-2H3,(H,23,24,25)	RWUSZRWKGUZDBQ-UHFFFAOYSA-N	247696	US9688672, Example 298::US9434719, 298::US10112931, Example 298	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 38.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247696&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452048	346542235							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564984	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@H](C)c2cn(cn2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H20ClFN6O3/c1-11(16-8-27(10-24-16)14-5-3-13(21)4-6-14)25-19-23-7-15(22)18(26-19)28-17(12(2)29)9-31-20(28)30/h3-8,10-12,17,29H,9H2,1-2H3,(H,23,25,26)	GREBTMQANDUXHS-UHFFFAOYSA-N	247697	US9688672, Example 299::US9434719, 299::US10112931, Example 299	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 457					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247697	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247697&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452050	346542236							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564985	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H20ClFN6O3/c1-11(16-8-27(10-24-16)14-5-3-13(21)4-6-14)25-19-23-7-15(22)18(26-19)28-17(12(2)29)9-31-20(28)30/h3-8,10-12,17,29H,9H2,1-2H3,(H,23,25,26)	GREBTMQANDUXHS-UHFFFAOYSA-N	247698	US9688672, Example 300::US9434719, 300::US10112931, Example 300	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10.00					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247698	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247698&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452052	346542237							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564986	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H20ClFN6O3/c1-11(16-8-27(10-24-16)14-5-3-13(21)4-6-14)25-19-23-7-15(22)18(26-19)28-17(12(2)29)9-31-20(28)30/h3-8,10-12,17,29H,9H2,1-2H3,(H,23,25,26)	GREBTMQANDUXHS-UHFFFAOYSA-N	247698	US9688672, Example 300::US9434719, 300::US10112931, Example 300	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247698	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247698&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452052	346542237							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564987	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(F)c(OCC(F)(F)F)cc2F)ncc1F |r|	InChI=1S/C19H18F6N4O4/c1-8(10-3-12(21)15(4-11(10)20)33-7-19(23,24)25)27-17-26-5-13(22)16(28-17)29-14(9(2)30)6-32-18(29)31/h3-5,8-9,14,30H,6-7H2,1-2H3,(H,26,27,28)	YZZWVWNMONRDBU-UHFFFAOYSA-N	247699	US9688672, Example 301::US9434719, 301::US10112931, Example 301	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 21.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247699	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247699&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452051	346542238							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564988	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(F)c(OCC(F)(F)F)cc2F)ncc1F |r|	InChI=1S/C19H18F6N4O4/c1-8(10-3-12(21)15(4-11(10)20)33-7-19(23,24)25)27-17-26-5-13(22)16(28-17)29-14(9(2)30)6-32-18(29)31/h3-5,8-9,14,30H,6-7H2,1-2H3,(H,26,27,28)	YZZWVWNMONRDBU-UHFFFAOYSA-N	247699	US9688672, Example 301::US9434719, 301::US10112931, Example 301	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 33.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247699	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247699&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452051	346542238							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564989	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OCC(F)(F)F)cc2F)ncc1F |r|	InChI=1S/C19H19F5N4O4/c1-9(12-4-3-11(5-13(12)20)32-8-19(22,23)24)26-17-25-6-14(21)16(27-17)28-15(10(2)29)7-31-18(28)30/h3-6,9-10,15,29H,7-8H2,1-2H3,(H,25,26,27)	LFTKBFBHPUUCMO-UHFFFAOYSA-N	247700	US9688672, Example 302::US9434719, 302::US10112931, Example 302	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 45.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247700	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247700&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452049	346542239							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564990	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OCC(F)(F)F)c(F)c2)ncc1F |r|	InChI=1S/C19H19F5N4O4/c1-9(11-3-4-15(12(20)5-11)32-8-19(22,23)24)26-17-25-6-13(21)16(27-17)28-14(10(2)29)7-31-18(28)30/h3-6,9-10,14,29H,7-8H2,1-2H3,(H,25,26,27)	WVFOOPQGQMFLTC-UHFFFAOYSA-N	247701	US9688672, Example 303::US9434719, 303::US10112931, Example 303	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 9.00					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247701	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247701&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452053	346542240							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564991	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OCC(F)(F)F)c(F)c2)ncc1F |r|	InChI=1S/C19H19F5N4O4/c1-9(11-3-4-15(12(20)5-11)32-8-19(22,23)24)26-17-25-6-13(21)16(27-17)28-14(10(2)29)7-31-18(28)30/h3-6,9-10,14,29H,7-8H2,1-2H3,(H,25,26,27)	WVFOOPQGQMFLTC-UHFFFAOYSA-N	247701	US9688672, Example 303::US9434719, 303::US10112931, Example 303	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 97.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247701	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247701&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452053	346542240							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564992	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccn(n2)-c2ccc(F)cc2)ncc1F |r|	InChI=1S/C20H20F2N6O3/c1-11(16-7-8-27(26-16)14-5-3-13(21)4-6-14)24-19-23-9-15(22)18(25-19)28-17(12(2)29)10-31-20(28)30/h3-9,11-12,17,29H,10H2,1-2H3,(H,23,24,25)	WTONQGGHWHWAFG-UHFFFAOYSA-N	247702	US9688672, Example 304::US9434719, 304::US10112931, Example 304	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 304					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247702	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247702&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452056	346542241							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564993	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OCC(F)(F)F)cn2)ncc1F |r|	InChI=1S/C18H19F4N5O4/c1-9(13-4-3-11(5-23-13)31-8-18(20,21)22)25-16-24-6-12(19)15(26-16)27-14(10(2)28)7-30-17(27)29/h3-6,9-10,14,28H,7-8H2,1-2H3,(H,24,25,26)	BDQMYRKYRKFFNS-UHFFFAOYSA-N	247703	US9688672, Example 305::US9434719, 305::US10112931, Example 305	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 968					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247703	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247703&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452055	346542242							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564994	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OCC(F)(F)F)cn2)ncc1F |r|	InChI=1S/C18H19F4N5O4/c1-9(13-4-3-11(5-23-13)31-8-18(20,21)22)25-16-24-6-12(19)15(26-16)27-14(10(2)28)7-30-17(27)29/h3-6,9-10,14,28H,7-8H2,1-2H3,(H,24,25,26)	BDQMYRKYRKFFNS-UHFFFAOYSA-N	247703	US9688672, Example 305::US9434719, 305::US10112931, Example 305	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 772					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247703	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247703&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452055	346542242							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564995	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@H](C)c2ccc(OCC(F)(F)F)cn2)ncc1F |r|	InChI=1S/C18H19F4N5O4/c1-9(13-4-3-11(5-23-13)31-8-18(20,21)22)25-16-24-6-12(19)15(26-16)27-14(10(2)28)7-30-17(27)29/h3-6,9-10,14,28H,7-8H2,1-2H3,(H,24,25,26)	BDQMYRKYRKFFNS-UHFFFAOYSA-N	247704	US9688672, Example 306::US9434719, 306::US10112931, Example 306	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2570					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247704	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247704&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452054	346542243							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564996	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H21ClN6O3/c1-12(16-9-26(11-23-16)15-5-3-14(21)4-6-15)24-19-22-8-7-18(25-19)27-17(13(2)28)10-30-20(27)29/h3-9,11-13,17,28H,10H2,1-2H3,(H,22,24,25)	YFYRVKRJXKSDNY-UHFFFAOYSA-N	247705	US9688672, Example 307::US9434719, 307 as TFA salt::US10112931, Example 307	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247705	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247705&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90413907	346542244							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564997	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H21ClN6O3/c1-12(16-9-26(11-23-16)15-5-3-14(21)4-6-15)24-19-22-8-7-18(25-19)27-17(13(2)28)10-30-20(27)29/h3-9,11-13,17,28H,10H2,1-2H3,(H,22,24,25)	YFYRVKRJXKSDNY-UHFFFAOYSA-N	247705	US9688672, Example 307::US9434719, 307 as TFA salt::US10112931, Example 307	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 38.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247705	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247705&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90413907	346542244							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564998	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccn(n2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H21ClN6O3/c1-12(16-8-10-26(25-16)15-5-3-14(21)4-6-15)23-19-22-9-7-18(24-19)27-17(13(2)28)11-30-20(27)29/h3-10,12-13,17,28H,11H2,1-2H3,(H,22,23,24)	KVRCKPJAUVKNSX-UHFFFAOYSA-N	247706	US9688672, Example 308::US9434719, 308 as TFA salt::US10112931, Example 308	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 49.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247706	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247706&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118121699	346542245							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
564999	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccn(n2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H21ClN6O3/c1-12(16-8-10-26(25-16)15-5-3-14(21)4-6-15)23-19-22-9-7-18(24-19)27-17(13(2)28)11-30-20(27)29/h3-10,12-13,17,28H,11H2,1-2H3,(H,22,23,24)	KVRCKPJAUVKNSX-UHFFFAOYSA-N	247706	US9688672, Example 308::US9434719, 308 as TFA salt::US10112931, Example 308	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 73.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247706	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247706&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118121699	346542245							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565000	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20Cl2N6O3/c1-11(15-8-27(10-23-15)14-5-3-13(21)4-6-14)24-19-25-17(22)7-18(26-19)28-16(12(2)29)9-31-20(28)30/h3-8,10-12,16,29H,9H2,1-2H3,(H,24,25,26)	OYVVZWSDLVZFTI-UHFFFAOYSA-N	247707	US9688672, Example 309::US9434719, 309::US10112931, Example 309	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3.00					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247707	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247707&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			85470932	346542246							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565001	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20Cl2N6O3/c1-11(15-8-27(10-23-15)14-5-3-13(21)4-6-14)24-19-25-17(22)7-18(26-19)28-16(12(2)29)9-31-20(28)30/h3-8,10-12,16,29H,9H2,1-2H3,(H,24,25,26)	OYVVZWSDLVZFTI-UHFFFAOYSA-N	247707	US9688672, Example 309::US9434719, 309::US10112931, Example 309	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4.00					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247707	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247707&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			85470932	346542246							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565002	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20Cl2N6O3/c1-11(15-8-27(10-23-15)14-5-3-13(21)4-6-14)24-19-25-17(22)7-18(26-19)28-16(12(2)29)9-31-20(28)30/h3-8,10-12,16,29H,9H2,1-2H3,(H,24,25,26)	OYVVZWSDLVZFTI-UHFFFAOYSA-N	247707	US9688672, Example 309::US9434719, 309::US10112931, Example 309	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3.00					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247707	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247707&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			85470932	346542246							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565003	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20Cl2N6O3/c1-11(15-8-27(10-23-15)14-5-3-13(21)4-6-14)24-19-25-17(22)7-18(26-19)28-16(12(2)29)9-31-20(28)30/h3-8,10-12,16,29H,9H2,1-2H3,(H,24,25,26)	OYVVZWSDLVZFTI-UHFFFAOYSA-N	247707	US9688672, Example 309::US9434719, 309::US10112931, Example 309	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4.00					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247707	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247707&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			85470932	346542246							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565004	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccn(n2)-c2ccc(F)cc2)n1 |r|	InChI=1S/C20H20ClFN6O3/c1-11(15-7-8-27(26-15)14-5-3-13(22)4-6-14)23-19-24-17(21)9-18(25-19)28-16(12(2)29)10-31-20(28)30/h3-9,11-12,16,29H,10H2,1-2H3,(H,23,24,25)	FSZZEMMBYJPKMX-UHFFFAOYSA-N	247708	US9688672, Example 310::US9434719, 310 as TFA salt::US10112931, Example 310	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 72.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247708	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247708&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118121688	346542247							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565005	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccn(n2)-c2ccc(F)cc2)n1 |r|	InChI=1S/C20H20ClFN6O3/c1-11(15-7-8-27(26-15)14-5-3-13(22)4-6-14)23-19-24-17(21)9-18(25-19)28-16(12(2)29)10-31-20(28)30/h3-9,11-12,16,29H,10H2,1-2H3,(H,23,24,25)	FSZZEMMBYJPKMX-UHFFFAOYSA-N	247708	US9688672, Example 310::US9434719, 310 as TFA salt::US10112931, Example 310	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 128					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247708	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247708&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118121688	346542247							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565006	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(Cl)cc2Cl)n1 |r|	InChI=1S/C17H18Cl2N4O3/c1-9(12-4-3-11(18)7-13(12)19)21-16-20-6-5-15(22-16)23-14(10(2)24)8-26-17(23)25/h3-7,9-10,14,24H,8H2,1-2H3,(H,20,21,22)	ZGKFKVBNBLHBED-UHFFFAOYSA-N	247709	US9688672, Example 311::US9434719, 311 as TFA salt::US10112931, Example 311	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 518					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247709	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247709&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452059	346542248							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565007	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(Cl)cc2Cl)n1 |r|	InChI=1S/C17H18Cl2N4O3/c1-9(12-4-3-11(18)7-13(12)19)21-16-20-6-5-15(22-16)23-14(10(2)24)8-26-17(23)25/h3-7,9-10,14,24H,8H2,1-2H3,(H,20,21,22)	ZGKFKVBNBLHBED-UHFFFAOYSA-N	247709	US9688672, Example 311::US9434719, 311 as TFA salt::US10112931, Example 311	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 445					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247709	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247709&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452059	346542248							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565008	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(Cl)c(Cl)c2)n1 |r|	InChI=1S/C17H18Cl2N4O3/c1-9(11-3-4-12(18)13(19)7-11)21-16-20-6-5-15(22-16)23-14(10(2)24)8-26-17(23)25/h3-7,9-10,14,24H,8H2,1-2H3,(H,20,21,22)	NLZRXHNICGFSSB-UHFFFAOYSA-N	247710	US9688672, Example 312::US9434719, 312 as TFA salt::US10112931, Example 312	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 66.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247710	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247710&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452058	346542249							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565009	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(Cl)c(Cl)c2)n1 |r|	InChI=1S/C17H18Cl2N4O3/c1-9(11-3-4-12(18)13(19)7-11)21-16-20-6-5-15(22-16)23-14(10(2)24)8-26-17(23)25/h3-7,9-10,14,24H,8H2,1-2H3,(H,20,21,22)	NLZRXHNICGFSSB-UHFFFAOYSA-N	247710	US9688672, Example 312::US9434719, 312 as TFA salt::US10112931, Example 312	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 144					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247710	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247710&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452058	346542249							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565010	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccn(n2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20Cl2N6O3/c1-11(15-7-8-27(26-15)14-5-3-13(21)4-6-14)23-19-24-17(22)9-18(25-19)28-16(12(2)29)10-31-20(28)30/h3-9,11-12,16,29H,10H2,1-2H3,(H,23,24,25)	RHVLPDFZYSXTKH-UHFFFAOYSA-N	247711	US9688672, Example 313::US9434719, 313 as TFA salt::US10112931, Example 313	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247711	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247711&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118121710	346542250							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565011	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccn(n2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20Cl2N6O3/c1-11(15-7-8-27(26-15)14-5-3-13(21)4-6-14)23-19-24-17(22)9-18(25-19)28-16(12(2)29)10-31-20(28)30/h3-9,11-12,16,29H,10H2,1-2H3,(H,23,24,25)	RHVLPDFZYSXTKH-UHFFFAOYSA-N	247711	US9688672, Example 313::US9434719, 313 as TFA salt::US10112931, Example 313	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 19.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247711	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247711&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118121710	346542250							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565012	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(OCC(F)(F)F)cc2F)n1 |r|	InChI=1S/C19H19F5N4O4/c1-9(11-5-13(21)15(6-12(11)20)32-8-19(22,23)24)26-17-25-4-3-16(27-17)28-14(10(2)29)7-31-18(28)30/h3-6,9-10,14,29H,7-8H2,1-2H3,(H,25,26,27)	AIKWSLRSPJRXMX-UHFFFAOYSA-N	247712	US9688672, Example 314::US9434719, 314 as TFA salt::US10112931, Example 314	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 106					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247712	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247712&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452061	346542251							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565013	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(OCC(F)(F)F)cc2F)n1 |r|	InChI=1S/C19H19F5N4O4/c1-9(11-5-13(21)15(6-12(11)20)32-8-19(22,23)24)26-17-25-4-3-16(27-17)28-14(10(2)29)7-31-18(28)30/h3-6,9-10,14,29H,7-8H2,1-2H3,(H,25,26,27)	AIKWSLRSPJRXMX-UHFFFAOYSA-N	247712	US9688672, Example 314::US9434719, 314 as TFA salt::US10112931, Example 314	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 157					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247712	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247712&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452061	346542251							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565014	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OCC(F)(F)F)cc2F)n1 |r|	InChI=1S/C19H20F4N4O4/c1-10(13-4-3-12(7-14(13)20)31-9-19(21,22)23)25-17-24-6-5-16(26-17)27-15(11(2)28)8-30-18(27)29/h3-7,10-11,15,28H,8-9H2,1-2H3,(H,24,25,26)	JOAMIQUKLNKTDJ-UHFFFAOYSA-N	247713	US9688672, Example 315::US9434719, 315 as TFA salt::US10112931, Example 315	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 161					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247713	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247713&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452069	346542252							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565015	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OCC(F)(F)F)cc2F)n1 |r|	InChI=1S/C19H20F4N4O4/c1-10(13-4-3-12(7-14(13)20)31-9-19(21,22)23)25-17-24-6-5-16(26-17)27-15(11(2)28)8-30-18(27)29/h3-7,10-11,15,28H,8-9H2,1-2H3,(H,24,25,26)	JOAMIQUKLNKTDJ-UHFFFAOYSA-N	247713	US9688672, Example 315::US9434719, 315 as TFA salt::US10112931, Example 315	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 350					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247713	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247713&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452069	346542252							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565016	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OCC(F)(F)F)c(F)c2)n1 |r|	InChI=1S/C19H20F4N4O4/c1-10(12-3-4-15(13(20)7-12)31-9-19(21,22)23)25-17-24-6-5-16(26-17)27-14(11(2)28)8-30-18(27)29/h3-7,10-11,14,28H,8-9H2,1-2H3,(H,24,25,26)	BLTGWFIGQAUGPI-UHFFFAOYSA-N	247714	US9688672, Example 316::US9434719, 316 as TFA salt::US10112931, Example 316	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 123					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247714	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247714&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452060	346542253							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565017	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OCC(F)(F)F)c(F)c2)n1 |r|	InChI=1S/C19H20F4N4O4/c1-10(12-3-4-15(13(20)7-12)31-9-19(21,22)23)25-17-24-6-5-16(26-17)27-14(11(2)28)8-30-18(27)29/h3-7,10-11,14,28H,8-9H2,1-2H3,(H,24,25,26)	BLTGWFIGQAUGPI-UHFFFAOYSA-N	247714	US9688672, Example 316::US9434719, 316 as TFA salt::US10112931, Example 316	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 261					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247714	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247714&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452060	346542253							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565018	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(Br)cn2)n1 |r|	InChI=1S/C16H18BrN5O3/c1-9(12-4-3-11(17)7-19-12)20-15-18-6-5-14(21-15)22-13(10(2)23)8-25-16(22)24/h3-7,9-10,13,23H,8H2,1-2H3,(H,18,20,21)	PUDVPUCKGIGHBC-UHFFFAOYSA-N	247715	US9688672, Example 317::US9434719, 317 as TFA salt::US10112931, Example 317	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3700					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247715	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247715&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452065	346542254							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565019	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@H](C)c2ccc(Br)cn2)n1 |r|	InChI=1S/C16H18BrN5O3/c1-9(12-4-3-11(17)7-19-12)20-15-18-6-5-14(21-15)22-13(10(2)23)8-25-16(22)24/h3-7,9-10,13,23H,8H2,1-2H3,(H,18,20,21)	PUDVPUCKGIGHBC-UHFFFAOYSA-N	247716	US9688672, Example 318::US9434719, 318 as TFA salt::US10112931, Example 318	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>25000					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247716	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247716&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452067	346542255							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565020	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(Cl)c(Cl)cc2F)n1 |r|	InChI=1S/C17H17Cl2FN4O3/c1-8(10-5-11(18)12(19)6-13(10)20)22-16-21-4-3-15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	MQSONJGUBHNIMZ-UHFFFAOYSA-N	247717	US9688672, Example 319::US9434719, 319 as TFA salt::US10112931, Example 319	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 35.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247717	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247717&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452062	346542256							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565021	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(Cl)c(Cl)cc2F)n1 |r|	InChI=1S/C17H17Cl2FN4O3/c1-8(10-5-11(18)12(19)6-13(10)20)22-16-21-4-3-15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	MQSONJGUBHNIMZ-UHFFFAOYSA-N	247717	US9688672, Example 319::US9434719, 319 as TFA salt::US10112931, Example 319	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 86.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247717	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247717&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452062	346542256							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565022	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-n2cnc(C)c2)n1 |r|	InChI=1S/C21H22F2N6O3/c1-11-8-28(10-25-11)17-7-15(22)14(6-16(17)23)12(2)26-20-24-5-4-19(27-20)29-18(13(3)30)9-32-21(29)31/h4-8,10,12-13,18,30H,9H2,1-3H3,(H,24,26,27)	NUNXMAPPGUYGGL-UHFFFAOYSA-N	247718	US9688672, Example 320::US9434719, 320 as TFA salt::US10112931, Example 320	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 426					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247718	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247718&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118121700	346542257							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565023	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-n2cnc(C)c2)n1 |r|	InChI=1S/C21H22F2N6O3/c1-11-8-28(10-25-11)17-7-15(22)14(6-16(17)23)12(2)26-20-24-5-4-19(27-20)29-18(13(3)30)9-32-21(29)31/h4-8,10,12-13,18,30H,9H2,1-3H3,(H,24,26,27)	NUNXMAPPGUYGGL-UHFFFAOYSA-N	247718	US9688672, Example 320::US9434719, 320 as TFA salt::US10112931, Example 320	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 381					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247718	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247718&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118121700	346542257							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565024	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(Cl)c(Cl)cc2F)ncc1Cl |r|	InChI=1S/C17H16Cl3FN4O3/c1-7(9-3-10(18)11(19)4-13(9)21)23-16-22-5-12(20)15(24-16)25-14(8(2)26)6-28-17(25)27/h3-5,7-8,14,26H,6H2,1-2H3,(H,22,23,24)	JILITIHKUXGCRP-UHFFFAOYSA-N	247955	US9434719, 321 as TFA salt::US10112931, Example 321	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 13.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247955	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247955&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452064	346542489							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565025	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(Cl)c(Cl)cc2F)ncc1Cl |r|	InChI=1S/C17H16Cl3FN4O3/c1-7(9-3-10(18)11(19)4-13(9)21)23-16-22-5-12(20)15(24-16)25-14(8(2)26)6-28-17(25)27/h3-5,7-8,14,26H,6H2,1-2H3,(H,22,23,24)	JILITIHKUXGCRP-UHFFFAOYSA-N	247955	US9434719, 321 as TFA salt::US10112931, Example 321	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 87.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247955	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247955&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452064	346542489							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565026	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-c2ccnc(C)c2)n1 |r|	InChI=1S/C23H23F2N5O3/c1-12-8-15(4-6-26-12)17-10-18(24)16(9-19(17)25)13(2)28-22-27-7-5-21(29-22)30-20(14(3)31)11-33-23(30)32/h4-10,13-14,20,31H,11H2,1-3H3,(H,27,28,29)	MIZZAXMUDXGBTL-UHFFFAOYSA-N	247719	US9688672, Example 322::US9434719, 322 as TFA salt::US10112931, Example 322	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 55.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247719&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268803	346542258							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565027	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-c2ccnc(C)c2)n1 |r|	InChI=1S/C23H23F2N5O3/c1-12-8-15(4-6-26-12)17-10-18(24)16(9-19(17)25)13(2)28-22-27-7-5-21(29-22)30-20(14(3)31)11-33-23(30)32/h4-10,13-14,20,31H,11H2,1-3H3,(H,27,28,29)	MIZZAXMUDXGBTL-UHFFFAOYSA-N	247719	US9688672, Example 322::US9434719, 322 as TFA salt::US10112931, Example 322	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 42.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247719&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86268803	346542258							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565028	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-c2ccc(C)nc2)n1 |r|	InChI=1S/C23H23F2N5O3/c1-12-4-5-15(10-27-12)17-9-18(24)16(8-19(17)25)13(2)28-22-26-7-6-21(29-22)30-20(14(3)31)11-33-23(30)32/h4-10,13-14,20,31H,11H2,1-3H3,(H,26,28,29)	CBMZECRSIJOBEO-UHFFFAOYSA-N	247720	US9688672, Example 323::US9434719, 323 as TFA salt::US10112931, Example 323	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 71.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247720	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247720&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452068	346542259							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565029	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-c2ccc(C)nc2)n1 |r|	InChI=1S/C23H23F2N5O3/c1-12-4-5-15(10-27-12)17-9-18(24)16(8-19(17)25)13(2)28-22-26-7-6-21(29-22)30-20(14(3)31)11-33-23(30)32/h4-10,13-14,20,31H,11H2,1-3H3,(H,26,28,29)	CBMZECRSIJOBEO-UHFFFAOYSA-N	247720	US9688672, Example 323::US9434719, 323 as TFA salt::US10112931, Example 323	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 72.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247720	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247720&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452068	346542259							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565030	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C23H20F5N5O3/c1-11(31-21-30-6-4-20(32-21)33-18(12(2)34)10-36-22(33)35)14-8-17(25)15(9-16(14)24)13-3-5-29-19(7-13)23(26,27)28/h3-9,11-12,18,34H,10H2,1-2H3,(H,30,31,32)	DZFQRZNEFQNGMD-UHFFFAOYSA-N	247721	US9688672, Example 324::US9434719, 324 as TFA salt::US10112931, Example 324	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 30.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247721&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452066	346542260							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565031	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-c2ccc(nc2)C(F)(F)F)n1 |r|	InChI=1S/C23H20F5N5O3/c1-11(31-21-29-6-5-20(32-21)33-18(12(2)34)10-36-22(33)35)14-7-17(25)15(8-16(14)24)13-3-4-19(30-9-13)23(26,27)28/h3-9,11-12,18,34H,10H2,1-2H3,(H,29,31,32)	DZGGVPVGJLJAFA-UHFFFAOYSA-N	247722	US9688672, Example 325::US9434719, 325 as TFA salt::US10112931, Example 325	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 41.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247722	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247722&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452070	346542261							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565032	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-c2ccc(nc2)C(F)(F)F)n1 |r|	InChI=1S/C23H20F5N5O3/c1-11(31-21-29-6-5-20(32-21)33-18(12(2)34)10-36-22(33)35)14-7-17(25)15(8-16(14)24)13-3-4-19(30-9-13)23(26,27)28/h3-9,11-12,18,34H,10H2,1-2H3,(H,29,31,32)	DZGGVPVGJLJAFA-UHFFFAOYSA-N	247722	US9688672, Example 325::US9434719, 325 as TFA salt::US10112931, Example 325	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 181					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247722	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247722&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452070	346542261							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565033	CC(C)COc1ccc(cc1)[C@H](C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O |r|	InChI=1S/C21H28N4O4/c1-13(2)11-28-17-7-5-16(6-8-17)14(3)23-20-22-10-9-19(24-20)25-18(15(4)26)12-29-21(25)27/h5-10,13-15,18,26H,11-12H2,1-4H3,(H,22,23,24)	BNQMHZZWBOBODR-UHFFFAOYSA-N	247723	US9688672, Example 326::US9434719, 326 as TFA salt::US10112931, Example 326	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 63.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247723	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247723&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454331	346542262							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565034	COc1ccc([C@H](C)Nc2ncc(F)c(n2)N2[C@H](COC2=O)[C@@H](C)O)c(F)c1 |r|	InChI=1S/C18H20F2N4O4/c1-9(12-5-4-11(27-3)6-13(12)19)22-17-21-7-14(20)16(23-17)24-15(10(2)25)8-28-18(24)26/h4-7,9-10,15,25H,8H2,1-3H3,(H,21,22,23)	DQUGIFZLFAYLDQ-UHFFFAOYSA-N	247724	US9688672, Example 327::US9434719, 327 as TFA salt::US10112931, Example 327	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 236					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247724&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454305	346542263							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565035	COc1ccc([C@H](C)Nc2ncc(F)c(n2)N2[C@H](COC2=O)[C@@H](C)O)c(F)c1 |r|	InChI=1S/C18H20F2N4O4/c1-9(12-5-4-11(27-3)6-13(12)19)22-17-21-7-14(20)16(23-17)24-15(10(2)25)8-28-18(24)26/h4-7,9-10,15,25H,8H2,1-3H3,(H,21,22,23)	DQUGIFZLFAYLDQ-UHFFFAOYSA-N	247724	US9688672, Example 327::US9434719, 327 as TFA salt::US10112931, Example 327	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 562					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247724&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454305	346542263							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565036	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cccc(F)c2F)n1 |r|	InChI=1S/C17H18F2N4O3/c1-9(11-4-3-5-12(18)15(11)19)21-16-20-7-6-14(22-16)23-13(10(2)24)8-26-17(23)25/h3-7,9-10,13,24H,8H2,1-2H3,(H,20,21,22)	FWULJMBJDVDQPS-UHFFFAOYSA-N	247725	US9688672, Example 328::US9434719, 328 as TFA salt::US10112931, Example 328	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1800					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247725	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247725&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454410	346542264							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565037	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cccc(F)c2F)ncc1F |r|	InChI=1S/C17H17F3N4O3/c1-8(10-4-3-5-11(18)14(10)20)22-16-21-6-12(19)15(23-16)24-13(9(2)25)7-27-17(24)26/h3-6,8-9,13,25H,7H2,1-2H3,(H,21,22,23)	JJBVNJOXQQKWHK-UHFFFAOYSA-N	247726	US9688672, Example 329::US9434719, 329 as TFA salt::US10112931, Example 329	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 863					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247726	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247726&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454413	346542265							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565038	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cccc(F)c2F)ncc1F |r|	InChI=1S/C17H17F3N4O3/c1-8(10-4-3-5-11(18)14(10)20)22-16-21-6-12(19)15(23-16)24-13(9(2)25)7-27-17(24)26/h3-6,8-9,13,25H,7H2,1-2H3,(H,21,22,23)	JJBVNJOXQQKWHK-UHFFFAOYSA-N	247726	US9688672, Example 329::US9434719, 329 as TFA salt::US10112931, Example 329	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 435					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247726	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247726&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454413	346542265							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565039	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(F)c(F)c2)ncc1F |r|	InChI=1S/C17H17F3N4O3/c1-8(10-3-4-11(18)12(19)5-10)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	WAPMSDNNNKZXNB-UHFFFAOYSA-N	247727	US9688672, Example 330::US9434719, 330 as TFA salt::US10112931, Example 330	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 268					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247727	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247727&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454308	346542266							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565040	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(F)c(F)c2)ncc1F |r|	InChI=1S/C17H17F3N4O3/c1-8(10-3-4-11(18)12(19)5-10)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	WAPMSDNNNKZXNB-UHFFFAOYSA-N	247727	US9688672, Example 330::US9434719, 330 as TFA salt::US10112931, Example 330	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 850					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247727	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247727&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454308	346542266							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565041	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(F)cc2F)ncc1F |r|	InChI=1S/C17H17F3N4O3/c1-8(11-4-3-10(18)5-12(11)19)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	FGUKTBUGWSRXPO-UHFFFAOYSA-N	247728	US9688672, Example 331::US9434719, 331 as TFA salt::US10112931, Example 331	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 190					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247728	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247728&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454306	346542267							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565042	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(F)cc2F)ncc1F |r|	InChI=1S/C17H17F3N4O3/c1-8(11-4-3-10(18)5-12(11)19)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	FGUKTBUGWSRXPO-UHFFFAOYSA-N	247728	US9688672, Example 331::US9434719, 331 as TFA salt::US10112931, Example 331	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 780					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247728	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247728&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454306	346542267							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565043	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(F)cc(F)c2)ncc1F |r|	InChI=1S/C17H17F3N4O3/c1-8(10-3-11(18)5-12(19)4-10)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	GJCKVKJRXJEBFW-UHFFFAOYSA-N	247729	US9688672, Example 332::US9434719, 332 as TFA salt::US10112931, Example 332	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1020					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247729	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247729&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454412	346542268							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565044	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(F)cc(F)c2)ncc1F |r|	InChI=1S/C17H17F3N4O3/c1-8(10-3-11(18)5-12(19)4-10)22-16-21-6-13(20)15(23-16)24-14(9(2)25)7-27-17(24)26/h3-6,8-9,14,25H,7H2,1-2H3,(H,21,22,23)	GJCKVKJRXJEBFW-UHFFFAOYSA-N	247729	US9688672, Example 332::US9434719, 332 as TFA salt::US10112931, Example 332	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 704					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247729	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247729&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454412	346542268							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565045	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ncc(cn2)-c2ccnc(c2)C(F)(F)F)ncc1Cl |r|	InChI=1S/C21H19ClF3N7O3/c1-10(17-27-6-13(7-28-17)12-3-4-26-16(5-12)21(23,24)25)30-19-29-8-14(22)18(31-19)32-15(11(2)33)9-35-20(32)34/h3-8,10-11,15,33H,9H2,1-2H3,(H,29,30,31)	SJEQFJFYRZCISY-UHFFFAOYSA-N	247730	US9688672, Example 333::US9434719, 333 as TFA salt::US10112931, Example 333	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 944					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247730	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247730&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454437	346542269							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565046	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ncc(cn2)-c2ccnc(c2)C(F)(F)F)ncc1Cl |r|	InChI=1S/C21H19ClF3N7O3/c1-10(17-27-6-13(7-28-17)12-3-4-26-16(5-12)21(23,24)25)30-19-29-8-14(22)18(31-19)32-15(11(2)33)9-35-20(32)34/h3-8,10-11,15,33H,9H2,1-2H3,(H,29,30,31)	SJEQFJFYRZCISY-UHFFFAOYSA-N	247730	US9688672, Example 333::US9434719, 333 as TFA salt::US10112931, Example 333	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 640					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247730	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247730&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454437	346542269							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565047	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OCC(F)(F)F)nc2)ncc1F |r|	InChI=1S/C18H19F4N5O4/c1-9(11-3-4-14(23-5-11)31-8-18(20,21)22)25-16-24-6-12(19)15(26-16)27-13(10(2)28)7-30-17(27)29/h3-6,9-10,13,28H,7-8H2,1-2H3,(H,24,25,26)	OEGBQUWOHADSRG-UHFFFAOYSA-N	247731	US9688672, Example 334::US9434719, 334 as TFA salt::US10112931, Example 334	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 341					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247731	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247731&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90417127	346542270							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565048	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OCC(F)(F)F)nc2)ncc1F |r|	InChI=1S/C18H19F4N5O4/c1-9(11-3-4-14(23-5-11)31-8-18(20,21)22)25-16-24-6-12(19)15(26-16)27-13(10(2)28)7-30-17(27)29/h3-6,9-10,13,28H,7-8H2,1-2H3,(H,24,25,26)	OEGBQUWOHADSRG-UHFFFAOYSA-N	247731	US9688672, Example 334::US9434719, 334 as TFA salt::US10112931, Example 334	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 943					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247731	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247731&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90417127	346542270							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565049	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)C(F)F)ncc1F |r|	InChI=1S/C18H18F4N4O3/c1-8(11-4-3-10(15(21)22)5-12(11)19)24-17-23-6-13(20)16(25-17)26-14(9(2)27)7-29-18(26)28/h3-6,8-9,14-15,27H,7H2,1-2H3,(H,23,24,25)	TYNNDJIMSFTUKJ-UHFFFAOYSA-N	247732	US9688672, Example 335::US9434719, 335 as TFA salt::US10112931, Example 335	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 257					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247732	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247732&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414384	346542271							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565050	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)C(F)F)ncc1F |r|	InChI=1S/C18H18F4N4O3/c1-8(11-4-3-10(15(21)22)5-12(11)19)24-17-23-6-13(20)16(25-17)26-14(9(2)27)7-29-18(26)28/h3-6,8-9,14-15,27H,7H2,1-2H3,(H,23,24,25)	TYNNDJIMSFTUKJ-UHFFFAOYSA-N	247732	US9688672, Example 335::US9434719, 335 as TFA salt::US10112931, Example 335	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 166					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247732	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247732&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414384	346542271							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565051	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)C(C)(F)F)ncc1F |r|	InChI=1S/C19H20F4N4O3/c1-9(12-5-4-11(6-13(12)20)19(3,22)23)25-17-24-7-14(21)16(26-17)27-15(10(2)28)8-30-18(27)29/h4-7,9-10,15,28H,8H2,1-3H3,(H,24,25,26)	FXGBDOOFJISKMB-UHFFFAOYSA-N	247733	US9688672, Example 336::US9434719, 336::US10112931, Example 336	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 35.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247733	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247733&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414216	346542272							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565052	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)C(C)(F)F)ncc1F |r|	InChI=1S/C19H20F4N4O3/c1-9(12-5-4-11(6-13(12)20)19(3,22)23)25-17-24-7-14(21)16(26-17)27-15(10(2)28)8-30-18(27)29/h4-7,9-10,15,28H,8H2,1-3H3,(H,24,25,26)	FXGBDOOFJISKMB-UHFFFAOYSA-N	247733	US9688672, Example 336::US9434719, 336::US10112931, Example 336	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 49.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247733	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247733&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414216	346542272							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565053	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)C(C)(F)F)ncc1F |r|	InChI=1S/C19H20F4N4O3/c1-9(12-5-4-11(6-13(12)20)19(3,22)23)25-17-24-7-14(21)16(26-17)27-15(10(2)28)8-30-18(27)29/h4-7,9-10,15,28H,8H2,1-3H3,(H,24,25,26)	FXGBDOOFJISKMB-UHFFFAOYSA-N	247733	US9688672, Example 336::US9434719, 336::US10112931, Example 336	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 27.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247733	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247733&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414216	346542272							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565054	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2F)C(C)(F)F)ncc1F |r|	InChI=1S/C19H20F4N4O3/c1-9(12-5-4-11(6-13(12)20)19(3,22)23)25-17-24-7-14(21)16(26-17)27-15(10(2)28)8-30-18(27)29/h4-7,9-10,15,28H,8H2,1-3H3,(H,24,25,26)	FXGBDOOFJISKMB-UHFFFAOYSA-N	247733	US9688672, Example 336::US9434719, 336::US10112931, Example 336	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 48.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247733	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247733&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414216	346542272							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565055	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(cc2F)C(F)F)n1 |r|	InChI=1S/C18H18ClF3N4O3/c1-8(11-4-3-10(16(21)22)5-12(11)20)23-17-24-14(19)6-15(25-17)26-13(9(2)27)7-29-18(26)28/h3-6,8-9,13,16,27H,7H2,1-2H3,(H,23,24,25)	GWDKSDYMGHXQMI-UHFFFAOYSA-N	175572	US9688672, Example 337::US10112931, Example 337	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 313					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175572&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415594	363892413							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565056	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(cc2F)C(F)F)n1 |r|	InChI=1S/C18H18ClF3N4O3/c1-8(11-4-3-10(16(21)22)5-12(11)20)23-17-24-14(19)6-15(25-17)26-13(9(2)27)7-29-18(26)28/h3-6,8-9,13,16,27H,7H2,1-2H3,(H,23,24,25)	GWDKSDYMGHXQMI-UHFFFAOYSA-N	175572	US9688672, Example 337::US10112931, Example 337	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 119					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175572&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415594	363892413							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565057	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(cc2F)C(C)(F)F)n1 |r|	InChI=1S/C19H20ClF3N4O3/c1-9(12-5-4-11(6-13(12)21)19(3,22)23)24-17-25-15(20)7-16(26-17)27-14(10(2)28)8-30-18(27)29/h4-7,9-10,14,28H,8H2,1-3H3,(H,24,25,26)	JKPMOPSJPVARMR-UHFFFAOYSA-N	175573	US9688672, Example 338::US10112931, Example 338	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 91.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175573&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415070	363892414							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565058	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(cc2F)C(C)(F)F)n1 |r|	InChI=1S/C19H20ClF3N4O3/c1-9(12-5-4-11(6-13(12)21)19(3,22)23)24-17-25-15(20)7-16(26-17)27-14(10(2)28)8-30-18(27)29/h4-7,9-10,14,28H,8H2,1-3H3,(H,24,25,26)	JKPMOPSJPVARMR-UHFFFAOYSA-N	175573	US9688672, Example 338::US10112931, Example 338	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 93.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175573&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415070	363892414							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565059	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(s2)-c2ccccc2)n1 |r|	InChI=1S/C21H21ClN4O3S/c1-12(16-8-9-17(30-16)14-6-4-3-5-7-14)23-20-24-18(22)10-19(25-20)26-15(13(2)27)11-29-21(26)28/h3-10,12-13,15,27H,11H2,1-2H3,(H,23,24,25)	LOJDRZQZYPCFHT-UHFFFAOYSA-N	247736	US9688672, Example 339::US9434719, 339 as TFA salt::US10112931, Example 339	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247736	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247736&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416664	346542275							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565060	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(s2)-c2ccccc2)n1 |r|	InChI=1S/C21H21ClN4O3S/c1-12(16-8-9-17(30-16)14-6-4-3-5-7-14)23-20-24-18(22)10-19(25-20)26-15(13(2)27)11-29-21(26)28/h3-10,12-13,15,27H,11H2,1-2H3,(H,23,24,25)	LOJDRZQZYPCFHT-UHFFFAOYSA-N	247736	US9688672, Example 339::US9434719, 339 as TFA salt::US10112931, Example 339	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 24.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247736	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247736&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416664	346542275							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565061	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(s2)-c2ccccn2)n1 |r|	InChI=1S/C20H20ClN5O3S/c1-11(15-6-7-16(30-15)13-5-3-4-8-22-13)23-19-24-17(21)9-18(25-19)26-14(12(2)27)10-29-20(26)28/h3-9,11-12,14,27H,10H2,1-2H3,(H,23,24,25)	MIPXSCOEYZXMHU-UHFFFAOYSA-N	247737	US9688672, Example 340::US9434719, 340 as TFA salt::US10112931, Example 340	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 61.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247737	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247737&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90417102	346542276							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565062	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(s2)-c2ccccn2)n1 |r|	InChI=1S/C20H20ClN5O3S/c1-11(15-6-7-16(30-15)13-5-3-4-8-22-13)23-19-24-17(21)9-18(25-19)26-14(12(2)27)10-29-20(26)28/h3-9,11-12,14,27H,10H2,1-2H3,(H,23,24,25)	MIPXSCOEYZXMHU-UHFFFAOYSA-N	247737	US9688672, Example 340::US9434719, 340 as TFA salt::US10112931, Example 340	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 120					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247737	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247737&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90417102	346542276							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565063	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cccc(O[C@H]3CCOC3)c2)n1 |r|	InChI=1S/C21H26N4O5/c1-13(15-4-3-5-16(10-15)30-17-7-9-28-11-17)23-20-22-8-6-19(24-20)25-18(14(2)26)12-29-21(25)27/h3-6,8,10,13-14,17-18,26H,7,9,11-12H2,1-2H3,(H,22,23,24)	GGQKMNMZJGIESS-UHFFFAOYSA-N	247738	US9688672, Example 341::US9434719, 341 as TFA salt::US10112931, Example 341	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7050					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247738	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247738&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414484	346542277							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565064	CC(C)COc1cccc(c1)[C@H](C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O |r|	InChI=1S/C21H28N4O4/c1-13(2)11-28-17-7-5-6-16(10-17)14(3)23-20-22-9-8-19(24-20)25-18(15(4)26)12-29-21(25)27/h5-10,13-15,18,26H,11-12H2,1-4H3,(H,22,23,24)	HBTZBVJYHABTQW-UHFFFAOYSA-N	247739	US9688672, Example 342::US9434719, 342 as TFA salt::US10112931, Example 342	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 465					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247739	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247739&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454416	346542278							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565065	CC(C)COc1cccc(c1)[C@H](C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O |r|	InChI=1S/C21H28N4O4/c1-13(2)11-28-17-7-5-6-16(10-17)14(3)23-20-22-9-8-19(24-20)25-18(15(4)26)12-29-21(25)27/h5-10,13-15,18,26H,11-12H2,1-4H3,(H,22,23,24)	HBTZBVJYHABTQW-UHFFFAOYSA-N	247739	US9688672, Example 342::US9434719, 342 as TFA salt::US10112931, Example 342	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4001					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247739	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247739&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454416	346542278							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565066	CC(C)CS(=O)(=O)c1ccc(cc1)[C@H](C)Nc1nc(Cl)cc(n1)N1[C@H](COC1=O)[C@@H](C)O |r|	InChI=1S/C21H27ClN4O5S/c1-12(2)11-32(29,30)16-7-5-15(6-8-16)13(3)23-20-24-18(22)9-19(25-20)26-17(14(4)27)10-31-21(26)28/h5-9,12-14,17,27H,10-11H2,1-4H3,(H,23,24,25)	VSYICTLIYPIIPO-UHFFFAOYSA-N	247740	US9688672, Example 343::US9434719, 343 as TFA salt::US10112931, Example 343	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 73.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247740	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247740&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454445	346542279							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565067	CC(C)CS(=O)(=O)c1ccc(cc1)[C@H](C)Nc1nc(Cl)cc(n1)N1[C@H](COC1=O)[C@@H](C)O |r|	InChI=1S/C21H27ClN4O5S/c1-12(2)11-32(29,30)16-7-5-15(6-8-16)13(3)23-20-24-18(22)9-19(25-20)26-17(14(4)27)10-31-21(26)28/h5-9,12-14,17,27H,10-11H2,1-4H3,(H,23,24,25)	VSYICTLIYPIIPO-UHFFFAOYSA-N	247740	US9688672, Example 343::US9434719, 343 as TFA salt::US10112931, Example 343	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 225					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247740	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247740&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454445	346542279							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565068	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OC(F)(F)F)cc2)n1 |r|	InChI=1S/C18H19F3N4O4/c1-10(12-3-5-13(6-4-12)29-18(19,20)21)23-16-22-8-7-15(24-16)25-14(11(2)26)9-28-17(25)27/h3-8,10-11,14,26H,9H2,1-2H3,(H,22,23,24)	MBCIKYUWMXLUQE-UHFFFAOYSA-N	247741	US9688672, Example 344::US9434719, 344 as TFA salt::US10112931, Example 344	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 190					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247741	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247741&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454417	346542280							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565069	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OC(F)(F)F)cc2)n1 |r|	InChI=1S/C18H19F3N4O4/c1-10(12-3-5-13(6-4-12)29-18(19,20)21)23-16-22-8-7-15(24-16)25-14(11(2)26)9-28-17(25)27/h3-8,10-11,14,26H,9H2,1-2H3,(H,22,23,24)	MBCIKYUWMXLUQE-UHFFFAOYSA-N	247741	US9688672, Example 344::US9434719, 344 as TFA salt::US10112931, Example 344	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 300					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247741	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247741&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454417	346542280							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565070	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OC(F)(F)F)c(F)c2)n1 |r|	InChI=1S/C18H18F4N4O4/c1-9(11-3-4-14(12(19)7-11)30-18(20,21)22)24-16-23-6-5-15(25-16)26-13(10(2)27)8-29-17(26)28/h3-7,9-10,13,27H,8H2,1-2H3,(H,23,24,25)	ANLABPQVTMIFQY-UHFFFAOYSA-N	247742	US9688672, Example 345::US9434719, 345 as TFA salt::US10112931, Example 345	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 201					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247742	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247742&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454309	346542281							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565071	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OC(F)(F)F)c(F)c2)n1 |r|	InChI=1S/C18H18F4N4O4/c1-9(11-3-4-14(12(19)7-11)30-18(20,21)22)24-16-23-6-5-15(25-16)26-13(10(2)27)8-29-17(26)28/h3-7,9-10,13,27H,8H2,1-2H3,(H,23,24,25)	ANLABPQVTMIFQY-UHFFFAOYSA-N	247742	US9688672, Example 345::US9434719, 345 as TFA salt::US10112931, Example 345	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 378					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247742	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247742&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454309	346542281							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565072	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OC(F)(F)F)cc2F)n1 |r|	InChI=1S/C18H18F4N4O4/c1-9(12-4-3-11(7-13(12)19)30-18(20,21)22)24-16-23-6-5-15(25-16)26-14(10(2)27)8-29-17(26)28/h3-7,9-10,14,27H,8H2,1-2H3,(H,23,24,25)	KPRPSTUXEKHBOA-UHFFFAOYSA-N	247743	US9688672, Example 346::US9434719, 346 as TFA salt::US10112931, Example 346	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 189					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247743	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247743&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454353	346542282							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565073	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OC(F)(F)F)cc2F)n1 |r|	InChI=1S/C18H18F4N4O4/c1-9(12-4-3-11(7-13(12)19)30-18(20,21)22)24-16-23-6-5-15(25-16)26-14(10(2)27)8-29-17(26)28/h3-7,9-10,14,27H,8H2,1-2H3,(H,23,24,25)	KPRPSTUXEKHBOA-UHFFFAOYSA-N	247743	US9688672, Example 346::US9434719, 346 as TFA salt::US10112931, Example 346	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 290					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247743	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247743&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454353	346542282							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565074	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OC(F)F)c(F)c2)n1 |r|	InChI=1S/C18H19F3N4O4/c1-9(11-3-4-14(12(19)7-11)29-16(20)21)23-17-22-6-5-15(24-17)25-13(10(2)26)8-28-18(25)27/h3-7,9-10,13,16,26H,8H2,1-2H3,(H,22,23,24)	DYUBLOOWSLOZII-UHFFFAOYSA-N	247744	US9688672, Example 347::US9434719, 347 as TFA salt::US10112931, Example 347	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 395					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247744	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247744&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454441	346542283							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565075	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OC(F)F)c(F)c2)n1 |r|	InChI=1S/C18H19F3N4O4/c1-9(11-3-4-14(12(19)7-11)29-16(20)21)23-17-22-6-5-15(24-17)25-13(10(2)26)8-28-18(25)27/h3-7,9-10,13,16,26H,8H2,1-2H3,(H,22,23,24)	DYUBLOOWSLOZII-UHFFFAOYSA-N	247744	US9688672, Example 347::US9434719, 347 as TFA salt::US10112931, Example 347	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 564					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247744	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247744&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454441	346542283							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565076	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OC(F)F)c(F)c2)ncc1F |r|	InChI=1S/C18H18F4N4O4/c1-8(10-3-4-14(11(19)5-10)30-16(21)22)24-17-23-6-12(20)15(25-17)26-13(9(2)27)7-29-18(26)28/h3-6,8-9,13,16,27H,7H2,1-2H3,(H,23,24,25)	KPAIFCRBNKBGFW-UHFFFAOYSA-N	247745	US9688672, Example 348::US9434719, 348 as TFA salt::US10112931, Example 348	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 177					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247745	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247745&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454322	346542284							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565077	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OC(F)F)c(F)c2)ncc1F |r|	InChI=1S/C18H18F4N4O4/c1-8(10-3-4-14(11(19)5-10)30-16(21)22)24-17-23-6-12(20)15(25-17)26-13(9(2)27)7-29-18(26)28/h3-6,8-9,13,16,27H,7H2,1-2H3,(H,23,24,25)	KPAIFCRBNKBGFW-UHFFFAOYSA-N	247745	US9688672, Example 348::US9434719, 348 as TFA salt::US10112931, Example 348	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 128					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247745	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247745&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454322	346542284							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565078	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OC(F)F)cc2)n1 |r|	InChI=1S/C18H20F2N4O4/c1-10(12-3-5-13(6-4-12)28-16(19)20)22-17-21-8-7-15(23-17)24-14(11(2)25)9-27-18(24)26/h3-8,10-11,14,16,25H,9H2,1-2H3,(H,21,22,23)	XWGFOVNGXKQOSI-UHFFFAOYSA-N	247746	US9688672, Example 349::US9434719, 349 as TFA salt::US10112931, Example 349	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 681					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247746	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247746&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454448	346542285							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565079	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OC(F)F)cc2F)n1 |r|	InChI=1S/C18H19F3N4O4/c1-9(12-4-3-11(7-13(12)19)29-16(20)21)23-17-22-6-5-15(24-17)25-14(10(2)26)8-28-18(25)27/h3-7,9-10,14,16,26H,8H2,1-2H3,(H,22,23,24)	YFLKUCNNFILRRP-UHFFFAOYSA-N	247747	US9688672, Example 350::US9434719, 350 as TFA salt::US10112931, Example 350	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 413					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247747	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247747&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454330	346542286							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565080	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cccc(OC(F)(F)F)c2)n1 |r|	InChI=1S/C18H19F3N4O4/c1-10(12-4-3-5-13(8-12)29-18(19,20)21)23-16-22-7-6-15(24-16)25-14(11(2)26)9-28-17(25)27/h3-8,10-11,14,26H,9H2,1-2H3,(H,22,23,24)	PKLONOWRTBRHFD-UHFFFAOYSA-N	247748	US9688672, Example 351::US9434719, 351 as TFA salt::US10112931, Example 351	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 168					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247748	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247748&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454411	346542287							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565081	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cccc(OC(F)F)c2)n1 |r|	InChI=1S/C18H20F2N4O4/c1-10(12-4-3-5-13(8-12)28-16(19)20)22-17-21-7-6-15(23-17)24-14(11(2)25)9-27-18(24)26/h3-8,10-11,14,16,25H,9H2,1-2H3,(H,21,22,23)	PKRAGBQEVPWLDS-UHFFFAOYSA-N	247749	US9688672, Example 352::US9434719, 352 as TFA salt::US10112931, Example 352	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 770					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247749	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247749&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454419	346542288							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565082	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OC(F)F)cc2F)ncc1F |r|	InChI=1S/C18H18F4N4O4/c1-8(11-4-3-10(5-12(11)19)30-16(21)22)24-17-23-6-13(20)15(25-17)26-14(9(2)27)7-29-18(26)28/h3-6,8-9,14,16,27H,7H2,1-2H3,(H,23,24,25)	YDCZLLOGUUVLIS-UHFFFAOYSA-N	247750	US9688672, Example 353::US9434719, 353 as TFA salt::US10112931, Example 353	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 103					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247750	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247750&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454335	346542289							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565083	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OC(F)F)cc2F)ncc1F |r|	InChI=1S/C18H18F4N4O4/c1-8(11-4-3-10(5-12(11)19)30-16(21)22)24-17-23-6-13(20)15(25-17)26-14(9(2)27)7-29-18(26)28/h3-6,8-9,14,16,27H,7H2,1-2H3,(H,23,24,25)	YDCZLLOGUUVLIS-UHFFFAOYSA-N	247750	US9688672, Example 353::US9434719, 353 as TFA salt::US10112931, Example 353	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 117					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247750	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247750&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454335	346542289							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565084	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cccc(OC(F)(F)F)c2)ncc1F |r|	InChI=1S/C18H18F4N4O4/c1-9(11-4-3-5-12(6-11)30-18(20,21)22)24-16-23-7-13(19)15(25-16)26-14(10(2)27)8-29-17(26)28/h3-7,9-10,14,27H,8H2,1-2H3,(H,23,24,25)	JSGZIGKPIXFXHH-UHFFFAOYSA-N	247751	US9688672, Example 354::US9434719, 354 as TFA salt::US10112931, Example 354	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 51.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247751	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247751&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454312	346542290							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565085	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cccc(OC(F)(F)F)c2)ncc1F |r|	InChI=1S/C18H18F4N4O4/c1-9(11-4-3-5-12(6-11)30-18(20,21)22)24-16-23-7-13(19)15(25-16)26-14(10(2)27)8-29-17(26)28/h3-7,9-10,14,27H,8H2,1-2H3,(H,23,24,25)	JSGZIGKPIXFXHH-UHFFFAOYSA-N	247751	US9688672, Example 354::US9434719, 354 as TFA salt::US10112931, Example 354	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 286					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247751	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247751&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454312	346542290							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565086	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cccc(OC(F)F)c2)ncc1F |r|	InChI=1S/C18H19F3N4O4/c1-9(11-4-3-5-12(6-11)29-16(20)21)23-17-22-7-13(19)15(24-17)25-14(10(2)26)8-28-18(25)27/h3-7,9-10,14,16,26H,8H2,1-2H3,(H,22,23,24)	LMGCJWUBCBQFCU-UHFFFAOYSA-N	247752	US9688672, Example 355::US9434719, 355 as TFA salt::US10112931, Example 355	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 152					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247752	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247752&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454444	346542291							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565087	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cccc(OC(F)F)c2)ncc1F |r|	InChI=1S/C18H19F3N4O4/c1-9(11-4-3-5-12(6-11)29-16(20)21)23-17-22-7-13(19)15(24-17)25-14(10(2)26)8-28-18(25)27/h3-7,9-10,14,16,26H,8H2,1-2H3,(H,22,23,24)	LMGCJWUBCBQFCU-UHFFFAOYSA-N	247752	US9688672, Example 355::US9434719, 355 as TFA salt::US10112931, Example 355	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 381					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247752	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247752&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454444	346542291							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565088	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cccc(Oc3ccccc3)c2)n1 |r|	InChI=1S/C23H24N4O4/c1-15(17-7-6-10-19(13-17)31-18-8-4-3-5-9-18)25-22-24-12-11-21(26-22)27-20(16(2)28)14-30-23(27)29/h3-13,15-16,20,28H,14H2,1-2H3,(H,24,25,26)	AEQXLYPLJRGDNI-UHFFFAOYSA-N	247753	US9688672, Example 356::US9434719, 356 as TFA salt::US10112931, Example 356	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 120					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247753	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247753&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416330	346542292							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565089	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cccc(Oc3ccccc3)c2)n1 |r|	InChI=1S/C23H24N4O4/c1-15(17-7-6-10-19(13-17)31-18-8-4-3-5-9-18)25-22-24-12-11-21(26-22)27-20(16(2)28)14-30-23(27)29/h3-13,15-16,20,28H,14H2,1-2H3,(H,24,25,26)	AEQXLYPLJRGDNI-UHFFFAOYSA-N	247753	US9688672, Example 356::US9434719, 356 as TFA salt::US10112931, Example 356	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 132					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247753	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247753&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416330	346542292							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565090	CC(C)Oc1ccc(cc1)[C@H](C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O |r|	InChI=1S/C20H26N4O4/c1-12(2)28-16-7-5-15(6-8-16)13(3)22-19-21-10-9-18(23-19)24-17(14(4)25)11-27-20(24)26/h5-10,12-14,17,25H,11H2,1-4H3,(H,21,22,23)	OJWQIUREUZEYHW-UHFFFAOYSA-N	247754	US9688672, Example 357::US9434719, 357 as TFA salt::US10112931, Example 357	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 358					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247754	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247754&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454415	346542293							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565091	CC(C)Oc1ccc(cc1)[C@H](C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O |r|	InChI=1S/C20H26N4O4/c1-12(2)28-16-7-5-15(6-8-16)13(3)22-19-21-10-9-18(23-19)24-17(14(4)25)11-27-20(24)26/h5-10,12-14,17,25H,11H2,1-4H3,(H,21,22,23)	OJWQIUREUZEYHW-UHFFFAOYSA-N	247754	US9688672, Example 357::US9434719, 357 as TFA salt::US10112931, Example 357	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 439					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247754	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247754&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454415	346542293							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565092	CC(C)COc1ccc(cc1C)[C@H](C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O |r|	InChI=1S/C22H30N4O4/c1-13(2)11-29-19-7-6-17(10-14(19)3)15(4)24-21-23-9-8-20(25-21)26-18(16(5)27)12-30-22(26)28/h6-10,13,15-16,18,27H,11-12H2,1-5H3,(H,23,24,25)	GHWKXMZIPLJSMM-UHFFFAOYSA-N	247755	US9688672, Example 358::US9434719, 358 as TFA salt::US10112931, Example 358	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 123					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247755	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247755&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454311	346542294							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565093	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(OC(F)(F)F)cc2)n1 |r|	InChI=1S/C18H18ClF3N4O4/c1-9(11-3-5-12(6-4-11)30-18(20,21)22)23-16-24-14(19)7-15(25-16)26-13(10(2)27)8-29-17(26)28/h3-7,9-10,13,27H,8H2,1-2H3,(H,23,24,25)	SLTPWQWFEDBFLL-UHFFFAOYSA-N	247756	US9688672, Example 359::US9434719, 359 as TFA salt::US10112931, Example 359	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 171					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247756	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247756&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454325	346542295							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565094	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(OC(F)(F)F)cc2)n1 |r|	InChI=1S/C18H18ClF3N4O4/c1-9(11-3-5-12(6-4-11)30-18(20,21)22)23-16-24-14(19)7-15(25-16)26-13(10(2)27)8-29-17(26)28/h3-7,9-10,13,27H,8H2,1-2H3,(H,23,24,25)	SLTPWQWFEDBFLL-UHFFFAOYSA-N	247756	US9688672, Example 359::US9434719, 359 as TFA salt::US10112931, Example 359	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 193					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247756	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247756&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454325	346542295							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565095	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OC(F)(F)F)cc2)ncc1F |r|	InChI=1S/C18H18F4N4O4/c1-9(11-3-5-12(6-4-11)30-18(20,21)22)24-16-23-7-13(19)15(25-16)26-14(10(2)27)8-29-17(26)28/h3-7,9-10,14,27H,8H2,1-2H3,(H,23,24,25)	SWVDZCOMSHWEEZ-UHFFFAOYSA-N	247757	US9688672, Example 360::US9434719, 360 as TFA salt::US10112931, Example 360	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 56.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247757	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247757&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454340	346542296							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565096	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OC(F)(F)F)cc2)ncc1F |r|	InChI=1S/C18H18F4N4O4/c1-9(11-3-5-12(6-4-11)30-18(20,21)22)24-16-23-7-13(19)15(25-16)26-14(10(2)27)8-29-17(26)28/h3-7,9-10,14,27H,8H2,1-2H3,(H,23,24,25)	SWVDZCOMSHWEEZ-UHFFFAOYSA-N	247757	US9688672, Example 360::US9434719, 360 as TFA salt::US10112931, Example 360	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 119					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247757	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247757&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454340	346542296							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565097	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(OC(F)(F)F)cc2F)n1 |r|	InChI=1S/C18H17ClF4N4O4/c1-8(11-4-3-10(5-12(11)20)31-18(21,22)23)24-16-25-14(19)6-15(26-16)27-13(9(2)28)7-30-17(27)29/h3-6,8-9,13,28H,7H2,1-2H3,(H,24,25,26)	SWAWFUARYJDPBB-UHFFFAOYSA-N	247758	US9688672, Example 361::US9434719, 361 as TFA salt::US10112931, Example 361	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 107					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247758	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247758&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454314	346542297							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565098	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(OC(F)(F)F)cc2F)n1 |r|	InChI=1S/C18H17ClF4N4O4/c1-8(11-4-3-10(5-12(11)20)31-18(21,22)23)24-16-25-14(19)6-15(26-16)27-13(9(2)28)7-30-17(27)29/h3-6,8-9,13,28H,7H2,1-2H3,(H,24,25,26)	SWAWFUARYJDPBB-UHFFFAOYSA-N	247758	US9688672, Example 361::US9434719, 361 as TFA salt::US10112931, Example 361	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 170					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247758	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247758&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454314	346542297							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565099	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OC(F)(F)F)cc2F)ncc1F |r|	InChI=1S/C18H17F5N4O4/c1-8(11-4-3-10(5-12(11)19)31-18(21,22)23)25-16-24-6-13(20)15(26-16)27-14(9(2)28)7-30-17(27)29/h3-6,8-9,14,28H,7H2,1-2H3,(H,24,25,26)	HDTHZQWZFMBYRG-UHFFFAOYSA-N	247759	US9688672, Example 362::US9434719, 362 as TFA salt::US10112931, Example 362	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 72.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247759	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247759&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454351	346542298							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565100	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OC(F)(F)F)cc2F)ncc1F |r|	InChI=1S/C18H17F5N4O4/c1-8(11-4-3-10(5-12(11)19)31-18(21,22)23)25-16-24-6-13(20)15(26-16)27-14(9(2)28)7-30-17(27)29/h3-6,8-9,14,28H,7H2,1-2H3,(H,24,25,26)	HDTHZQWZFMBYRG-UHFFFAOYSA-N	247759	US9688672, Example 362::US9434719, 362 as TFA salt::US10112931, Example 362	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 142					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247759	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247759&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454351	346542298							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565101	CC(C)COc1ccc([C@H](C)Nc2ncc(F)c(n2)N2[C@H](COC2=O)[C@@H](C)O)c(F)c1 |r|	InChI=1S/C21H26F2N4O4/c1-11(2)9-30-14-5-6-15(16(22)7-14)12(3)25-20-24-8-17(23)19(26-20)27-18(13(4)28)10-31-21(27)29/h5-8,11-13,18,28H,9-10H2,1-4H3,(H,24,25,26)	DMKMOSRSPBXKFD-UHFFFAOYSA-N	247760	US9688672, Example 363::US9434719, 363 as TFA salt::US10112931, Example 363	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7.00					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247760	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247760&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269624	346542299							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565102	CC(C)COc1ccc([C@H](C)Nc2ncc(F)c(n2)N2[C@H](COC2=O)[C@@H](C)O)c(F)c1 |r|	InChI=1S/C21H26F2N4O4/c1-11(2)9-30-14-5-6-15(16(22)7-14)12(3)25-20-24-8-17(23)19(26-20)27-18(13(4)28)10-31-21(27)29/h5-8,11-13,18,28H,9-10H2,1-4H3,(H,24,25,26)	DMKMOSRSPBXKFD-UHFFFAOYSA-N	247760	US9688672, Example 363::US9434719, 363 as TFA salt::US10112931, Example 363	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 9.00					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247760	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247760&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269624	346542299							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565103	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OC(F)F)cc2)ncc1F |r|	InChI=1S/C18H19F3N4O4/c1-9(11-3-5-12(6-4-11)29-16(20)21)23-17-22-7-13(19)15(24-17)25-14(10(2)26)8-28-18(25)27/h3-7,9-10,14,16,26H,8H2,1-2H3,(H,22,23,24)	FQHLHYFBIHYYEA-UHFFFAOYSA-N	247761	US9688672, Example 364::US9434719, 364 as TFA salt::US10112931, Example 364	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 124					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247761	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247761&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454323	346542300							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565104	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OC(F)F)cc2)ncc1F |r|	InChI=1S/C18H19F3N4O4/c1-9(11-3-5-12(6-4-11)29-16(20)21)23-17-22-7-13(19)15(24-17)25-14(10(2)26)8-28-18(25)27/h3-7,9-10,14,16,26H,8H2,1-2H3,(H,22,23,24)	FQHLHYFBIHYYEA-UHFFFAOYSA-N	247761	US9688672, Example 364::US9434719, 364 as TFA salt::US10112931, Example 364	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 286					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247761	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247761&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454323	346542300							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565105	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OC(F)(F)F)c(F)c2)ncc1F |r|	InChI=1S/C18H17F5N4O4/c1-8(10-3-4-14(11(19)5-10)31-18(21,22)23)25-16-24-6-12(20)15(26-16)27-13(9(2)28)7-30-17(27)29/h3-6,8-9,13,28H,7H2,1-2H3,(H,24,25,26)	GYAMWEZQXHMOAV-UHFFFAOYSA-N	247762	US9688672, Example 365::US9434719, 365 as TFA salt::US10112931, Example 365	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 33.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247762	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247762&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454328	346542301							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565106	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(OC(F)(F)F)c(F)c2)ncc1F |r|	InChI=1S/C18H17F5N4O4/c1-8(10-3-4-14(11(19)5-10)31-18(21,22)23)25-16-24-6-12(20)15(26-16)27-13(9(2)28)7-30-17(27)29/h3-6,8-9,13,28H,7H2,1-2H3,(H,24,25,26)	GYAMWEZQXHMOAV-UHFFFAOYSA-N	247762	US9688672, Example 365::US9434719, 365 as TFA salt::US10112931, Example 365	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 137					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247762	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247762&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454328	346542301							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565107	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(OC(F)F)cc2)n1 |r|	InChI=1S/C18H19ClF2N4O4/c1-9(11-3-5-12(6-4-11)29-16(20)21)22-17-23-14(19)7-15(24-17)25-13(10(2)26)8-28-18(25)27/h3-7,9-10,13,16,26H,8H2,1-2H3,(H,22,23,24)	VLNLAVUCHCZALI-UHFFFAOYSA-N	247763	US9688672, Example 366::US9434719, 366 as TFA salt::US10112931, Example 366	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 151					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247763	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247763&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454337	346542302							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565108	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(OC(F)F)cc2)n1 |r|	InChI=1S/C18H19ClF2N4O4/c1-9(11-3-5-12(6-4-11)29-16(20)21)22-17-23-14(19)7-15(24-17)25-13(10(2)26)8-28-18(25)27/h3-7,9-10,13,16,26H,8H2,1-2H3,(H,22,23,24)	VLNLAVUCHCZALI-UHFFFAOYSA-N	247763	US9688672, Example 366::US9434719, 366 as TFA salt::US10112931, Example 366	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 345					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247763	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247763&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454337	346542302							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565109	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(OC(F)(F)F)c(F)c2)n1 |r|	InChI=1S/C18H17ClF4N4O4/c1-8(10-3-4-13(11(20)5-10)31-18(21,22)23)24-16-25-14(19)6-15(26-16)27-12(9(2)28)7-30-17(27)29/h3-6,8-9,12,28H,7H2,1-2H3,(H,24,25,26)	YRQFYFCQIZEOKP-UHFFFAOYSA-N	247764	US9688672, Example 367::US9434719, 367 as TFA salt::US10112931, Example 367	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 127					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247764	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247764&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454352	346542303							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565110	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(OC(F)(F)F)c(F)c2)n1 |r|	InChI=1S/C18H17ClF4N4O4/c1-8(10-3-4-13(11(20)5-10)31-18(21,22)23)24-16-25-14(19)6-15(26-16)27-12(9(2)28)7-30-17(27)29/h3-6,8-9,12,28H,7H2,1-2H3,(H,24,25,26)	YRQFYFCQIZEOKP-UHFFFAOYSA-N	247764	US9688672, Example 367::US9434719, 367 as TFA salt::US10112931, Example 367	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 209					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247764	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247764&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454352	346542303							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565111	CC(C)CS(=O)(=O)c1ccc(cc1)[C@H](C)Nc1ncc(F)c(n1)N1[C@H](COC1=O)[C@@H](C)O |r|	InChI=1S/C21H27FN4O5S/c1-12(2)11-32(29,30)16-7-5-15(6-8-16)13(3)24-20-23-9-17(22)19(25-20)26-18(14(4)27)10-31-21(26)28/h5-9,12-14,18,27H,10-11H2,1-4H3,(H,23,24,25)	BENRISSQCAMHJD-UHFFFAOYSA-N	247765	US9688672, Example 368::US9434719, 368 as TFA salt::US10112931, Example 368	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 91.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247765	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247765&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454315	346542304							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565112	CC(C)CS(=O)(=O)c1ccc(cc1)[C@H](C)Nc1ncc(F)c(n1)N1[C@H](COC1=O)[C@@H](C)O |r|	InChI=1S/C21H27FN4O5S/c1-12(2)11-32(29,30)16-7-5-15(6-8-16)13(3)24-20-23-9-17(22)19(25-20)26-18(14(4)27)10-31-21(26)28/h5-9,12-14,18,27H,10-11H2,1-4H3,(H,23,24,25)	BENRISSQCAMHJD-UHFFFAOYSA-N	247765	US9688672, Example 368::US9434719, 368 as TFA salt::US10112931, Example 368	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 127					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247765	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247765&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454315	346542304							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565113	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2)S(=O)(=O)C(C)C)ncc1F |r|	InChI=1S/C20H25FN4O5S/c1-11(2)31(28,29)15-7-5-14(6-8-15)12(3)23-19-22-9-16(21)18(24-19)25-17(13(4)26)10-30-20(25)27/h5-9,11-13,17,26H,10H2,1-4H3,(H,22,23,24)	AKIWXGQITISGLG-UHFFFAOYSA-N	247766	US9688672, Example 369::US9434719, 369 as TFA salt::US10112931, Example 369	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 397					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247766	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247766&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454327	346542305							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565114	C[C@@H](O)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ccc(cc2)S(=O)(=O)C(C)C)ncc1F |r|	InChI=1S/C20H25FN4O5S/c1-11(2)31(28,29)15-7-5-14(6-8-15)12(3)23-19-22-9-16(21)18(24-19)25-17(13(4)26)10-30-20(25)27/h5-9,11-13,17,26H,10H2,1-4H3,(H,22,23,24)	AKIWXGQITISGLG-UHFFFAOYSA-N	247766	US9688672, Example 369::US9434719, 369 as TFA salt::US10112931, Example 369	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1277					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247766	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247766&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454327	346542305							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565115	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(cc2)S(=O)(=O)C(C)C)n1 |r|	InChI=1S/C20H25ClN4O5S/c1-11(2)31(28,29)15-7-5-14(6-8-15)12(3)22-19-23-17(21)9-18(24-19)25-16(13(4)26)10-30-20(25)27/h5-9,11-13,16,26H,10H2,1-4H3,(H,22,23,24)	VYAVVBNXCNPSAJ-UHFFFAOYSA-N	247767	US9688672, Example 370::US9434719, 370 as TFA salt::US10112931, Example 370	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 441					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247767	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247767&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454420	346542306							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565116	C[C@@H](O)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(cc2)S(=O)(=O)C(C)C)n1 |r|	InChI=1S/C20H25ClN4O5S/c1-11(2)31(28,29)15-7-5-14(6-8-15)12(3)22-19-23-17(21)9-18(24-19)25-16(13(4)26)10-30-20(25)27/h5-9,11-13,16,26H,10H2,1-4H3,(H,22,23,24)	VYAVVBNXCNPSAJ-UHFFFAOYSA-N	247767	US9688672, Example 370::US9434719, 370 as TFA salt::US10112931, Example 370	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1303					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247767	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247767&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454420	346542306							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565117	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OCC3CC3)cc2)n1 |r|	InChI=1S/C21H26N4O4/c1-13(16-5-7-17(8-6-16)28-11-15-3-4-15)23-20-22-10-9-19(24-20)25-18(14(2)26)12-29-21(25)27/h5-10,13-15,18,26H,3-4,11-12H2,1-2H3,(H,22,23,24)	ZCOLCSIPNKKCDE-UHFFFAOYSA-N	247768	US9688672, Example 371::US9434719, 371 as TFA salt::US10112931, Example 371	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 125					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247768	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247768&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454354	346542307							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565118	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(OCC3CC3)cc2)n1 |r|	InChI=1S/C21H26N4O4/c1-13(16-5-7-17(8-6-16)28-11-15-3-4-15)23-20-22-10-9-19(24-20)25-18(14(2)26)12-29-21(25)27/h5-10,13-15,18,26H,3-4,11-12H2,1-2H3,(H,22,23,24)	ZCOLCSIPNKKCDE-UHFFFAOYSA-N	247768	US9688672, Example 371::US9434719, 371 as TFA salt::US10112931, Example 371	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 110					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247768	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247768&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454354	346542307							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565119	CC(C)COc1ccc([C@H](C)Nc2nccc(n2)N2[C@H](COC2=O)[C@@H](C)O)c(F)c1 |r|	InChI=1S/C21H27FN4O4/c1-12(2)10-29-15-5-6-16(17(22)9-15)13(3)24-20-23-8-7-19(25-20)26-18(14(4)27)11-30-21(26)28/h5-9,12-14,18,27H,10-11H2,1-4H3,(H,23,24,25)	LJIFTDXMEPVARJ-UHFFFAOYSA-N	247769	US9688672, Example 372::US9434719, 372 as TFA salt::US10112931, Example 372	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247769	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247769&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269625	346542308							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565120	CC(C)COc1ccc([C@H](C)Nc2nccc(n2)N2[C@H](COC2=O)[C@@H](C)O)c(F)c1 |r|	InChI=1S/C21H27FN4O4/c1-12(2)10-29-15-5-6-16(17(22)9-15)13(3)24-20-23-8-7-19(25-20)26-18(14(4)27)11-30-21(26)28/h5-9,12-14,18,27H,10-11H2,1-4H3,(H,23,24,25)	LJIFTDXMEPVARJ-UHFFFAOYSA-N	247769	US9688672, Example 372::US9434719, 372 as TFA salt::US10112931, Example 372	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247769	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247769&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269625	346542308							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565121	CO[C@H](C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H22ClN5O3S/c1-12(17-10-24-19(31-17)14-4-6-15(22)7-5-14)25-20-23-9-8-18(26-20)27-16(13(2)29-3)11-30-21(27)28/h4-10,12-13,16H,11H2,1-3H3,(H,23,25,26)	SAIODZDRCACKIB-UHFFFAOYSA-N	247770	US9688672, Example 373::US9434719, 373 as TFA salt::US10112931, Example 373	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 51.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247770	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247770&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414996	346542309							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565122	CO[C@H](C)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(F)c(cc2F)-c2cnn(C)c2)n1 |r|	InChI=1S/C22H23ClF2N6O3/c1-11(14-5-17(25)15(6-16(14)24)13-8-26-30(3)9-13)27-21-28-19(23)7-20(29-21)31-18(12(2)33-4)10-34-22(31)32/h5-9,11-12,18H,10H2,1-4H3,(H,27,28,29)	HNOZDTOTLCCUPT-UHFFFAOYSA-N	247771	US9688672, Example 374::US9434719, 374::US10112931, Example 374	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 32.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247771	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247771&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454332	346542310							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565123	CO[C@H](C)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cc(F)c(cc2F)-c2cnn(C)c2)n1 |r|	InChI=1S/C22H23ClF2N6O3/c1-11(14-5-17(25)15(6-16(14)24)13-8-26-30(3)9-13)27-21-28-19(23)7-20(29-21)31-18(12(2)33-4)10-34-22(31)32/h5-9,11-12,18H,10H2,1-4H3,(H,27,28,29)	HNOZDTOTLCCUPT-UHFFFAOYSA-N	247771	US9688672, Example 374::US9434719, 374::US10112931, Example 374	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 21.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247771	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247771&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454332	346542310							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565124	CO[C@H](C)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(cc2F)C(F)(F)F)n1 |r|	InChI=1S/C19H19ClF4N4O3/c1-9(12-5-4-11(6-13(12)21)19(22,23)24)25-17-26-15(20)7-16(27-17)28-14(10(2)30-3)8-31-18(28)29/h4-7,9-10,14H,8H2,1-3H3,(H,25,26,27)	IAZOCXPCSBFWIH-UHFFFAOYSA-N	247772	US9688672, Example 375::US9434719, 375::US10112931, Example 375	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 93.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247772	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247772&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454333	346542311							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565125	CO[C@H](C)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2ccc(cc2F)C(F)(F)F)n1 |r|	InChI=1S/C19H19ClF4N4O3/c1-9(12-5-4-11(6-13(12)21)19(22,23)24)25-17-26-15(20)7-16(27-17)28-14(10(2)30-3)8-31-18(28)29/h4-7,9-10,14H,8H2,1-3H3,(H,25,26,27)	IAZOCXPCSBFWIH-UHFFFAOYSA-N	247772	US9688672, Example 375::US9434719, 375::US10112931, Example 375	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 241					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247772	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247772&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454333	346542311							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565126	CO[C@H](C)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H21Cl2N5O3S/c1-11(16-9-24-19(32-16)13-4-6-14(22)7-5-13)25-20-26-17(23)8-18(27-20)28-15(12(2)30-3)10-31-21(28)29/h4-9,11-12,15H,10H2,1-3H3,(H,25,26,27)	IQBNFHYCKUJXMY-UHFFFAOYSA-N	247773	US9688672, Example 376::US9434719, 376 as TFA salt::US10112931, Example 376	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 23.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247773	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247773&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269626	346542312							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565127	CO[C@H](C)[C@H]1COC(=O)N1c1cc(Cl)nc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H21Cl2N5O3S/c1-11(16-9-24-19(32-16)13-4-6-14(22)7-5-13)25-20-26-17(23)8-18(27-20)28-15(12(2)30-3)10-31-21(28)29/h4-9,11-12,15H,10H2,1-3H3,(H,25,26,27)	IQBNFHYCKUJXMY-UHFFFAOYSA-N	247773	US9688672, Example 376::US9434719, 376 as TFA salt::US10112931, Example 376	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 27.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247773	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247773&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269626	346542312							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565128	CO[C@H](C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H22ClN5O4/c1-12(16-10-18(31-26-16)14-4-6-15(22)7-5-14)24-20-23-9-8-19(25-20)27-17(13(2)29-3)11-30-21(27)28/h4-10,12-13,17H,11H2,1-3H3,(H,23,24,25)	OCQDKNFJFBGAAN-UHFFFAOYSA-N	247774	US9688672, Example 377::US9434719, 377 as TFA salt::US10112931, Example 377	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 52.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247774	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247774&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454338	346542313							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565129	CO[C@H](C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H23ClN6O3/c1-13(17-10-27(12-24-17)16-6-4-15(22)5-7-16)25-20-23-9-8-19(26-20)28-18(14(2)30-3)11-31-21(28)29/h4-10,12-14,18H,11H2,1-3H3,(H,23,25,26)	ZXSRGQFMTVABKG-UHFFFAOYSA-N	247775	US9688672, Example 378::US9434719, 378 as TFA salt::US10112931, Example 378	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 25.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247775	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247775&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269627	346542314							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565130	CO[C@H](C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-c2ccc(C)nc2)n1 |r|	InChI=1S/C24H25F2N5O3/c1-13-5-6-16(11-28-13)18-10-19(25)17(9-20(18)26)14(2)29-23-27-8-7-22(30-23)31-21(15(3)33-4)12-34-24(31)32/h5-11,14-15,21H,12H2,1-4H3,(H,27,29,30)	PXWHOSZDRFRQIM-UHFFFAOYSA-N	247776	US9688672, Example 379::US9434719, 379 as TFA salt::US10112931, Example 379	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 53.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247776	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247776&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454447	346542315							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565131	C[C@@H](N)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H21ClN6O2S/c1-11(22)15-10-29-20(28)27(15)17-7-8-23-19(26-17)25-12(2)16-9-24-18(30-16)13-3-5-14(21)6-4-13/h3-9,11-12,15H,10,22H2,1-2H3,(H,23,25,26)	TWTIWFVVDBVARH-UHFFFAOYSA-N	247777	US9688672, Example 380::US9434719, 380::US10112931, Example 380	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 36.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247777&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269827	346542316							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565132	C[C@@H](N)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H21ClN6O2S/c1-11(22)15-10-29-20(28)27(15)17-7-8-23-19(26-17)25-12(2)16-9-24-18(30-16)13-3-5-14(21)6-4-13/h3-9,11-12,15H,10,22H2,1-2H3,(H,23,25,26)	TWTIWFVVDBVARH-UHFFFAOYSA-N	247777	US9688672, Example 380::US9434719, 380::US10112931, Example 380	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 50.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247777&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269827	346542316							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565133	C[C@@H](N)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H21ClN6O2S/c1-11(22)15-10-29-20(28)27(15)17-7-8-23-19(26-17)25-12(2)16-9-24-18(30-16)13-3-5-14(21)6-4-13/h3-9,11-12,15H,10,22H2,1-2H3,(H,23,25,26)	TWTIWFVVDBVARH-UHFFFAOYSA-N	247777	US9688672, Example 380::US9434719, 380::US10112931, Example 380	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 36.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247777&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269827	346542316							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565134	C[C@@H](N)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H22ClN7O2/c1-12(22)17-10-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)16-9-27(11-24-16)15-5-3-14(21)4-6-15/h3-9,11-13,17H,10,22H2,1-2H3,(H,23,25,26)	ZPVIMCNUFDJSOY-UHFFFAOYSA-N	247778	US9688672, Example 381::US9434719, 381 as TFA salt::US10112931, Example 381	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 139					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247778&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454339	346542317							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565135	C[C@@H](N)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H22ClN7O2/c1-12(22)17-10-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)16-9-27(11-24-16)15-5-3-14(21)4-6-15/h3-9,11-13,17H,10,22H2,1-2H3,(H,23,25,26)	ZPVIMCNUFDJSOY-UHFFFAOYSA-N	247778	US9688672, Example 381::US9434719, 381 as TFA salt::US10112931, Example 381	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 59.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247778&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454339	346542317							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565136	C[C@@H](N)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H21ClN6O3/c1-11(22)16-10-29-20(28)27(16)18-7-8-23-19(25-18)24-12(2)15-9-17(30-26-15)13-3-5-14(21)6-4-13/h3-9,11-12,16H,10,22H2,1-2H3,(H,23,24,25)	IFICRBVGACOUTK-UHFFFAOYSA-N	247779	US9688672, Example 382::US9434719, 382 as TFA salt::US10112931, Example 382	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 219					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247779&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454355	346542318							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565137	C[C@@H](N)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H21ClN6O3/c1-11(22)16-10-29-20(28)27(16)18-7-8-23-19(25-18)24-12(2)15-9-17(30-26-15)13-3-5-14(21)6-4-13/h3-9,11-12,16H,10,22H2,1-2H3,(H,23,24,25)	IFICRBVGACOUTK-UHFFFAOYSA-N	247779	US9688672, Example 382::US9434719, 382 as TFA salt::US10112931, Example 382	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 98.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247779&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454355	346542318							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565138	C[C@@H](N)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-c2ccc(C)nc2)n1 |r|	InChI=1S/C23H24F2N6O2/c1-12-4-5-15(10-28-12)17-9-18(24)16(8-19(17)25)14(3)29-22-27-7-6-21(30-22)31-20(13(2)26)11-33-23(31)32/h4-10,13-14,20H,11,26H2,1-3H3,(H,27,29,30)	VEDLXIHGLCIYPF-UHFFFAOYSA-N	247780	US9688672, Example 383::US9434719, 383 as TFA salt::US10112931, Example 383	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 164					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247780	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247780&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454336	346542319							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565139	CN[C@H](C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H23ClN6O2S/c1-12(23-3)16-11-30-21(29)28(16)18-8-9-24-20(27-18)26-13(2)17-10-25-19(31-17)14-4-6-15(22)7-5-14/h4-10,12-13,16,23H,11H2,1-3H3,(H,24,26,27)	HSAYUWLDZHIRGI-UHFFFAOYSA-N	247781	US9688672, Example 384::US9434719, 384 as TFA salt::US10112931, Example 384	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10500					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247781	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247781&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415677	346542320							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565140	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClFN6O2/c1-12(22)17-10-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)16-9-27(11-24-16)15-5-3-14(21)4-6-15/h3-9,11-13,17H,10H2,1-2H3,(H,23,25,26)	JJRFKCRKJUIUTG-UHFFFAOYSA-N	247782	US9688672, Example 385::US9434719, 385::US10112931, Example 385	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247782&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269828	346542321							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565141	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClFN6O2/c1-12(22)17-10-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)16-9-27(11-24-16)15-5-3-14(21)4-6-15/h3-9,11-13,17H,10H2,1-2H3,(H,23,25,26)	JJRFKCRKJUIUTG-UHFFFAOYSA-N	247782	US9688672, Example 385::US9434719, 385::US10112931, Example 385	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<23.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247782&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269828	346542321							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565142	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClFN6O2/c1-12(22)17-10-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)16-9-27(11-24-16)15-5-3-14(21)4-6-15/h3-9,11-13,17H,10H2,1-2H3,(H,23,25,26)	JJRFKCRKJUIUTG-UHFFFAOYSA-N	247782	US9688672, Example 385::US9434719, 385::US10112931, Example 385	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247782&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269828	346542321							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565143	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClFN6O2/c1-12(22)17-10-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)16-9-27(11-24-16)15-5-3-14(21)4-6-15/h3-9,11-13,17H,10H2,1-2H3,(H,23,25,26)	JJRFKCRKJUIUTG-UHFFFAOYSA-N	247782	US9688672, Example 385::US9434719, 385::US10112931, Example 385	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7.00					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247782&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269828	346542321							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565144	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H19ClFN5O3/c1-11(22)16-10-29-20(28)27(16)18-7-8-23-19(25-18)24-12(2)15-9-17(30-26-15)13-3-5-14(21)6-4-13/h3-9,11-12,16H,10H2,1-2H3,(H,23,24,25)	GQYRXSSAUNIXGN-UHFFFAOYSA-N	247783	US9688672, Example 386::US9434719, 386 as TFA salt::US10112931, Example 386	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 59.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247783	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247783&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454422	346542322							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565145	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H19ClFN5O2S/c1-11(22)15-10-29-20(28)27(15)17-7-8-23-19(26-17)25-12(2)16-9-24-18(30-16)13-3-5-14(21)6-4-13/h3-9,11-12,15H,10H2,1-2H3,(H,23,25,26)	YBAPMBOREDPGCY-UHFFFAOYSA-N	247784	US9688672, Example 387::US9434719, 387 as TFA salt::US10112931, Example 387	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 32.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247784&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454317	346542323							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565146	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClFN6O2/c1-12(22)17-10-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)16-9-27(11-24-16)15-5-3-14(21)4-6-15/h3-9,11-13,17H,10H2,1-2H3,(H,23,25,26)	JJRFKCRKJUIUTG-UHFFFAOYSA-N	247785	US9688672, Example 388::US9434719, 388 as TFA salt::US10112931, Example 388	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<15.9					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247785&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269829	346542324							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565147	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClFN6O2/c1-12(22)17-10-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)16-9-27(11-24-16)15-5-3-14(21)4-6-15/h3-9,11-13,17H,10H2,1-2H3,(H,23,25,26)	JJRFKCRKJUIUTG-UHFFFAOYSA-N	247785	US9688672, Example 388::US9434719, 388 as TFA salt::US10112931, Example 388	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 6.00					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247785&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269829	346542324							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565148	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H19ClFN5O2S/c1-11(22)15-10-29-20(28)27(15)17-7-8-23-19(26-17)25-12(2)16-9-24-18(30-16)13-3-5-14(21)6-4-13/h3-9,11-12,15H,10H2,1-2H3,(H,23,25,26)	YBAPMBOREDPGCY-UHFFFAOYSA-N	247786	US9688672, Example 389::US9434719, 389 as TFA salt::US10112931, Example 389	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247786&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86270013	346542325							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565149	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H19ClFN5O3/c1-11(22)16-10-29-20(28)27(16)18-7-8-23-19(25-18)24-12(2)15-9-17(30-26-15)13-3-5-14(21)6-4-13/h3-9,11-12,16H,10H2,1-2H3,(H,23,24,25)	GQYRXSSAUNIXGN-UHFFFAOYSA-N	247787	US9688672, Example 390::US9434719, 390 as TFA salt::US10112931, Example 390	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 22.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247787	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247787&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86270014	346542326							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565150	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H19ClFN5O3/c1-11(22)16-10-29-20(28)27(16)18-7-8-23-19(25-18)24-12(2)15-9-17(30-26-15)13-3-5-14(21)6-4-13/h3-9,11-12,16H,10H2,1-2H3,(H,23,24,25)	GQYRXSSAUNIXGN-UHFFFAOYSA-N	247787	US9688672, Example 390::US9434719, 390 as TFA salt::US10112931, Example 390	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 22.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247787	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247787&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86270014	346542326							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565151	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2nc(no2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C19H18ClFN6O3/c1-10(21)14-9-29-19(28)27(14)15-7-8-22-18(24-15)23-11(2)17-25-16(26-30-17)12-3-5-13(20)6-4-12/h3-8,10-11,14H,9H2,1-2H3,(H,22,23,24)	GWEUWUPKNPRHLY-UHFFFAOYSA-N	247788	US9688672, Example 391::US9434719, 391 as TFA salt::US10112931, Example 391	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 38.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247788	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247788&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454334	346542327							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565152	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C20H18F4N6O2S/c1-10(21)13-9-32-19(31)30(13)16-4-6-26-18(29-16)28-11(2)14-8-27-17(33-14)12-3-5-25-15(7-12)20(22,23)24/h3-8,10-11,13H,9H2,1-2H3,(H,26,28,29)	WGHDFKRAKKPLGU-UHFFFAOYSA-N	247789	US9688672, Example 392::US9434719, 392 as TFA salt::US10112931, Example 392	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 101					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247789&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454341	346542328							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565153	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccc(nc2)C(F)(F)F)n1 |r|	InChI=1S/C20H18F4N6O2S/c1-10(21)13-9-32-19(31)30(13)16-5-6-25-18(29-16)28-11(2)14-8-27-17(33-14)12-3-4-15(26-7-12)20(22,23)24/h3-8,10-11,13H,9H2,1-2H3,(H,25,28,29)	QITCTFCYZWAPJB-UHFFFAOYSA-N	247790	US9688672, Example 393::US9434719, 393 as TFA salt::US10112931, Example 393	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 57.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247790	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247790&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454446	346542329							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565154	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClFN6O2/c1-12(22)17-11-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)14-9-24-27(10-14)16-5-3-15(21)4-6-16/h3-10,12-13,17H,11H2,1-2H3,(H,23,25,26)	NJHKNRVBHGOLEU-UHFFFAOYSA-N	247791	US9688672, Example 394::US9434719, 394 as TFA salt::US10112931, Example 394	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 37.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247791&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454450	346542330							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565155	C[C@@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnc(s2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H18ClF2N5O2S/c1-10(22)15-9-30-20(29)28(15)17-14(23)7-25-19(27-17)26-11(2)16-8-24-18(31-16)12-3-5-13(21)6-4-12/h3-8,10-11,15H,9H2,1-2H3,(H,25,26,27)	UIZLKFKSWCSCMM-UHFFFAOYSA-N	247792	US9688672, Example 395::US9434719, 395 as TFA salt::US10112931, Example 395	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 34.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247792&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454342	346542331							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565156	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C20H20ClFN6O2/c1-12(22)17-11-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)14-9-24-27(10-14)16-5-3-15(21)4-6-16/h3-10,12-13,17H,11H2,1-2H3,(H,23,25,26)	NJHKNRVBHGOLEU-UHFFFAOYSA-N	247793	US9688672, Example 396::US9434719, 396 as TFA salt::US10112931, Example 396	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 24.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247793&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454329	346542332							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565157	C[C@@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H19ClF2N6O2/c1-11(22)17-10-31-20(30)29(17)18-16(23)8-24-19(27-18)26-12(2)13-7-25-28(9-13)15-5-3-14(21)4-6-15/h3-9,11-12,17H,10H2,1-2H3,(H,24,26,27)	YFWQMXWNYLZFPV-UHFFFAOYSA-N	247794	US9688672, Example 397::US9434719, 397 as TFA salt::US10112931, Example 397	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 64.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247794&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454421	346542333							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565158	C[C@@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H18ClF2N5O3/c1-10(22)16-9-30-20(29)28(16)18-14(23)8-24-19(26-18)25-11(2)15-7-17(31-27-15)12-3-5-13(21)6-4-12/h3-8,10-11,16H,9H2,1-2H3,(H,24,25,26)	KPUWPLMVSGVTML-UHFFFAOYSA-N	175633	US9688672, Example 398::US10112931, Example 398	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 38.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175633&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454449	363892473							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565159	C[C@@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H19ClF2N6O2/c1-11(22)17-9-31-20(30)29(17)18-15(23)7-24-19(27-18)26-12(2)16-8-28(10-25-16)14-5-3-13(21)4-6-14/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)	TXJIZORMCOMGCK-UHFFFAOYSA-N	247796	US9688672, Example 399::US9434719, 399 as TFA salt::US10112931, Example 399	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247796&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86270015	346542335							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565160	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(c(C)n2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H22ClFN6O2/c1-12(23)18-11-31-21(30)29(18)19-8-9-24-20(27-19)25-13(2)17-10-28(14(3)26-17)16-6-4-15(22)5-7-16/h4-10,12-13,18H,11H2,1-3H3,(H,24,25,27)	ZQMNNLVJLTTWPP-UHFFFAOYSA-N	247797	US9688672, Example 400::US9434719, 400 as TFA salt::US10112931, Example 400	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247797&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269830	346542336							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565161	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(F)cc2)n1 |r|	InChI=1S/C20H20F2N6O2/c1-12(21)17-10-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)16-9-27(11-24-16)15-5-3-14(22)4-6-15/h3-9,11-13,17H,10H2,1-2H3,(H,23,25,26)	QPJBWMOBPCRKLJ-UHFFFAOYSA-N	247798	US9688672, Example 401::US9434719, 401::US10112931, Example 401	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 23.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247798&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269831	346542337							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565162	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(F)cc2)n1 |r|	InChI=1S/C20H20F2N6O2/c1-12(21)17-10-30-20(29)28(17)18-7-8-23-19(26-18)25-13(2)16-9-27(11-24-16)15-5-3-14(22)4-6-15/h3-9,11-13,17H,10H2,1-2H3,(H,23,25,26)	QPJBWMOBPCRKLJ-UHFFFAOYSA-N	247798	US9688672, Example 401::US9434719, 401::US10112931, Example 401	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 18.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247798&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269831	346542337							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565163	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-n2cnc(C)c2)n1 |r|	InChI=1S/C21H21F3N6O2/c1-11-8-29(10-26-11)17-7-15(23)14(6-16(17)24)13(3)27-20-25-5-4-19(28-20)30-18(12(2)22)9-32-21(30)31/h4-8,10,12-13,18H,9H2,1-3H3,(H,25,27,28)	WXQFMXGYILZLDK-UHFFFAOYSA-N	247799	US9688672, Example 402::US9434719, 402 as TFA salt::US10112931, Example 402	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 44.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247799&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454356	346542338							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565164	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccn(n2)-c2ccc(nc2)C(F)(F)F)n1 |r|	InChI=1S/C20H19F4N7O2/c1-11(21)15-10-33-19(32)31(15)17-5-7-25-18(28-17)27-12(2)14-6-8-30(29-14)13-3-4-16(26-9-13)20(22,23)24/h3-9,11-12,15H,10H2,1-2H3,(H,25,27,28)	QLUIPEQIKSKHHT-UHFFFAOYSA-N	247800	US9688672, Example 403::US9434719, 403 as TFA salt::US10112931, Example 403	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 137					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247800	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247800&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415067	346542339							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565165	C[C@H](Nc1nccc(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(Cl)cc1 |r|	InChI=1S/C19H18ClFN6O2/c1-12(16-9-26(11-23-16)14-4-2-13(20)3-5-14)24-18-22-7-6-17(25-18)27-15(8-21)10-29-19(27)28/h2-7,9,11-12,15H,8,10H2,1H3,(H,22,24,25)	KPEQYRKGPMZOQE-UHFFFAOYSA-N	247801	US9688672, Example 404::US9434719, 404::US10112931, Example 404	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 21.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247801&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86269832	346542340							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565166	C[C@H](Nc1nccc(n1)N1[C@@H](CF)COC1=O)c1cc(on1)-c1ccc(Cl)cc1 |r|	InChI=1S/C19H17ClFN5O3/c1-11(15-8-16(29-25-15)12-2-4-13(20)5-3-12)23-18-22-7-6-17(24-18)26-14(9-21)10-28-19(26)27/h2-8,11,14H,9-10H2,1H3,(H,22,23,24)	BFRYXYOIUNFQSA-UHFFFAOYSA-N	247802	US9688672, Example 405::US9434719, 405::US10112931, Example 405	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 27.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247802&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452072	346542341							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565167	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(c(C)n2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C21H22ClFN6O2/c1-12(23)18-11-31-21(30)29(18)19-8-9-24-20(27-19)25-13(2)17-10-28(14(3)26-17)16-6-4-15(22)5-7-16/h4-10,12-13,18H,11H2,1-3H3,(H,24,25,27)	ZQMNNLVJLTTWPP-UHFFFAOYSA-N	247803	US9688672, Example 406::US9434719, 406 as TFA salt::US10112931, Example 406	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 28.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247803&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452073	346542342							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565168	CC(O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)C2CCN(CC2)c2ccnc(c2)C(C)(C)C(F)(F)F)n1 |r|	InChI=1S/C25H33F3N6O3/c1-15(31-22-30-10-6-21(32-22)34-19(16(2)35)14-37-23(34)36)17-7-11-33(12-8-17)18-5-9-29-20(13-18)24(3,4)25(26,27)28/h5-6,9-10,13,15-17,19,35H,7-8,11-12,14H2,1-4H3,(H,30,31,32)	WSAGULHYKDXCCD-UHFFFAOYSA-N	247804	US9688672, Example 407::US9434719, 407::US10112931, Example 407	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 71.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247804	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247804&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452074	346542343							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565169	CC(O)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)C2CCN(CC2)c2ccc(Cl)c(OC(F)(F)F)c2)n1 |r|	InChI=1S/C23H27ClF3N5O4/c1-13(29-21-28-8-5-20(30-21)32-18(14(2)33)12-35-22(32)34)15-6-9-31(10-7-15)16-3-4-17(24)19(11-16)36-23(25,26)27/h3-5,8,11,13-15,18,33H,6-7,9-10,12H2,1-2H3,(H,28,29,30)	GMDXACMJICLXKB-UHFFFAOYSA-N	175643	BDBM247805::US9688672, Example 408::US10112931, Example 408	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 43.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=175643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=175643&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			131635548	363892483							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565170	C[C@H](Nc1ncc(F)c(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1ccc(cc1F)C(F)F |r|	InChI=1S/C19H18F6N4O2/c1-8(15(22)23)14-7-31-19(30)29(14)17-13(21)6-26-18(28-17)27-9(2)11-4-3-10(16(24)25)5-12(11)20/h3-6,8-9,14-16H,7H2,1-2H3,(H,26,27,28)	SIYAUCMYORHPJS-UHFFFAOYSA-N	247806	US9688672, Example 409::US9434719, 409 as TFA salt::US10112931, Example 409	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 209					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247806&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414243	346542345							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565171	C[C@H](Nc1ncc(F)c(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1ccc(cc1F)C(F)F |r|	InChI=1S/C19H18F6N4O2/c1-8(15(22)23)14-7-31-19(30)29(14)17-13(21)6-26-18(28-17)27-9(2)11-4-3-10(16(24)25)5-12(11)20/h3-6,8-9,14-16H,7H2,1-2H3,(H,26,27,28)	SIYAUCMYORHPJS-UHFFFAOYSA-N	247806	US9688672, Example 409::US9434719, 409 as TFA salt::US10112931, Example 409	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 501					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247806&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414243	346542345							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565172	CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1nc(no1)-c1ccc(Cl)cc1 |r,w:1.0|	InChI=1S/C20H19ClF2N6O3/c1-10(16(22)23)14-9-31-20(30)29(14)15-7-8-24-19(26-15)25-11(2)18-27-17(28-32-18)12-3-5-13(21)6-4-12/h3-8,10-11,14,16H,9H2,1-2H3,(H,24,25,26)	NOOITAIFTJACTE-UHFFFAOYSA-N	247807	US9688672, Example 411::US9434719, 411 as TFA salt::US10112931, Example 411	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247807&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454326	346542346							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565173	CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1nc(no1)-c1ccc(Cl)cc1 |r,w:1.0|	InChI=1S/C20H19ClF2N6O3/c1-10(16(22)23)14-9-31-20(30)29(14)15-7-8-24-19(26-15)25-11(2)18-27-17(28-32-18)12-3-5-13(21)6-4-12/h3-8,10-11,14,16H,9H2,1-2H3,(H,24,25,26)	NOOITAIFTJACTE-UHFFFAOYSA-N	247807	US9688672, Example 411::US9434719, 411 as TFA salt::US10112931, Example 411	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 34.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247807&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454326	346542346							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565174	CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1nc(no1)-c1ccc(Cl)cc1 |r,w:1.0|	InChI=1S/C20H19ClF2N6O3/c1-10(16(22)23)14-9-31-20(30)29(14)15-7-8-24-19(26-15)25-11(2)18-27-17(28-32-18)12-3-5-13(21)6-4-12/h3-8,10-11,14,16H,9H2,1-2H3,(H,24,25,26)	NOOITAIFTJACTE-UHFFFAOYSA-N	247807	US9688672, Example 411::US9434719, 411 as TFA salt::US10112931, Example 411	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 756					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247807&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454326	346542346							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565175	CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1nc(no1)-c1ccc(Cl)cc1 |r,w:1.0|	InChI=1S/C20H19ClF2N6O3/c1-10(16(22)23)14-9-31-20(30)29(14)15-7-8-24-19(26-15)25-11(2)18-27-17(28-32-18)12-3-5-13(21)6-4-12/h3-8,10-11,14,16H,9H2,1-2H3,(H,24,25,26)	NOOITAIFTJACTE-UHFFFAOYSA-N	247807	US9688672, Example 411::US9434719, 411 as TFA salt::US10112931, Example 411	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1601					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247807&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454326	346542346							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565176	C[C@H](Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1ccc(cc1F)C(F)F |r|	InChI=1S/C19H19F5N4O2/c1-9(16(21)22)14-8-30-19(29)28(14)15-5-6-25-18(27-15)26-10(2)12-4-3-11(17(23)24)7-13(12)20/h3-7,9-10,14,16-17H,8H2,1-2H3,(H,25,26,27)	VLOHNXLYDJXLOT-UHFFFAOYSA-N	247808	US9688672, Example 412::US9434719, 412 as TFA salt::US10112931, Example 412	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 108					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247808&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414308	346542347							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565177	C[C@H](Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1ccc(cc1F)C(F)F |r|	InChI=1S/C19H19F5N4O2/c1-9(16(21)22)14-8-30-19(29)28(14)15-5-6-25-18(27-15)26-10(2)12-4-3-11(17(23)24)7-13(12)20/h3-7,9-10,14,16-17H,8H2,1-2H3,(H,25,26,27)	VLOHNXLYDJXLOT-UHFFFAOYSA-N	247808	US9688672, Example 412::US9434719, 412 as TFA salt::US10112931, Example 412	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 223					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247808&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414308	346542347							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565178	CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1ncc(cn1)-c1ccc(F)c(C)c1 |r,w:1.0|	InChI=1S/C23H23F3N6O2/c1-12-8-15(4-5-17(12)24)16-9-28-21(29-10-16)14(3)30-22-27-7-6-19(31-22)32-18(11-34-23(32)33)13(2)20(25)26/h4-10,13-14,18,20H,11H2,1-3H3,(H,27,30,31)	WWYFVFJZLKWRGV-UHFFFAOYSA-N	247809	US9688672, Example 414::US9434719, 414 as TFA salt::US10112931, Example 414	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 23.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247809&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454324	346542348							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565179	CC(Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1ncc(cn1)-c1ccc(F)c(C)c1 |r,w:1.0|	InChI=1S/C23H23F3N6O2/c1-12-8-15(4-5-17(12)24)16-9-28-21(29-10-16)14(3)30-22-27-7-6-19(31-22)32-18(11-34-23(32)33)13(2)20(25)26/h4-10,13-14,18,20H,11H2,1-3H3,(H,27,30,31)	WWYFVFJZLKWRGV-UHFFFAOYSA-N	247809	US9688672, Example 414::US9434719, 414 as TFA salt::US10112931, Example 414	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2210					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247809&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454324	346542348							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565180	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc3ccn(C)c3c2)n1 |r|	InChI=1S/C22H23N7O4/c1-12(20-26-19(27-33-20)15-5-4-14-7-9-28(3)16(14)10-15)24-21-23-8-6-18(25-21)29-17(13(2)30)11-32-22(29)31/h4-10,12-13,17,30H,11H2,1-3H3,(H,23,24,25)	HGCRGOJZYKVSGJ-UHFFFAOYSA-N	247810	US9688672, Example 415::US9434719, 415::US10112931, Example 415	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 483					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247810&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452076	346542349							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565181	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc3ccn(C)c3c2)n1 |r|	InChI=1S/C22H23N7O4/c1-12(20-26-19(27-33-20)15-5-4-14-7-9-28(3)16(14)10-15)24-21-23-8-6-18(25-21)29-17(13(2)30)11-32-22(29)31/h4-10,12-13,17,30H,11H2,1-3H3,(H,23,24,25)	HGCRGOJZYKVSGJ-UHFFFAOYSA-N	247810	US9688672, Example 415::US9434719, 415::US10112931, Example 415	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 204					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247810&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452076	346542349							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565182	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(OC(F)(F)F)c2)n1 |r|	InChI=1S/C20H19F3N6O5/c1-10(17-27-16(28-34-17)12-4-3-5-13(8-12)33-20(21,22)23)25-18-24-7-6-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)	ZJFRSZUNHMBIIV-UHFFFAOYSA-N	247811	US9688672, Example 416::US9434719, 416::US10112931, Example 416	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 97.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247811&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452075	346542350							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565183	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(OC(F)(F)F)c2)n1 |r|	InChI=1S/C20H19F3N6O5/c1-10(17-27-16(28-34-17)12-4-3-5-13(8-12)33-20(21,22)23)25-18-24-7-6-15(26-18)29-14(11(2)30)9-32-19(29)31/h3-8,10-11,14,30H,9H2,1-2H3,(H,24,25,26)	ZJFRSZUNHMBIIV-UHFFFAOYSA-N	247811	US9688672, Example 416::US9434719, 416::US10112931, Example 416	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 110					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247811&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452075	346542350							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565184	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc3n(C)c(C)cc23)n1 |r|	InChI=1S/C23H25N7O4/c1-12-10-16-15(6-5-7-17(16)29(12)4)20-27-21(34-28-20)13(2)25-22-24-9-8-19(26-22)30-18(14(3)31)11-33-23(30)32/h5-10,13-14,18,31H,11H2,1-4H3,(H,24,25,26)	GBVOTMFBOODMEE-UHFFFAOYSA-N	247812	US9688672, Example 417::US9434719, 417::US10112931, Example 417	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 207					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247812&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452078	346542351							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565185	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc3n(C)c(C)cc23)n1 |r|	InChI=1S/C23H25N7O4/c1-12-10-16-15(6-5-7-17(16)29(12)4)20-27-21(34-28-20)13(2)25-22-24-9-8-19(26-22)30-18(14(3)31)11-33-23(30)32/h5-10,13-14,18,31H,11H2,1-4H3,(H,24,25,26)	GBVOTMFBOODMEE-UHFFFAOYSA-N	247812	US9688672, Example 417::US9434719, 417::US10112931, Example 417	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 78.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247812&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452078	346542351							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565186	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)c(OC(F)(F)F)c2)n1 |r|	InChI=1S/C20H18ClF3N6O5/c1-9(26-18-25-6-5-15(27-18)30-13(10(2)31)8-33-19(30)32)17-28-16(29-35-17)11-3-4-12(21)14(7-11)34-20(22,23)24/h3-7,9-10,13,31H,8H2,1-2H3,(H,25,26,27)	NXPYTJOUNUPUMU-UHFFFAOYSA-N	247813	US9688672, Example 418::US9434719, 418::US10112931, Example 418	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 15.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247813&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452077	346542352							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565187	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)c(OC(F)(F)F)c2)n1 |r|	InChI=1S/C20H18ClF3N6O5/c1-9(26-18-25-6-5-15(27-18)30-13(10(2)31)8-33-19(30)32)17-28-16(29-35-17)11-3-4-12(21)14(7-11)34-20(22,23)24/h3-7,9-10,13,31H,8H2,1-2H3,(H,25,26,27)	NXPYTJOUNUPUMU-UHFFFAOYSA-N	247813	US9688672, Example 418::US9434719, 418::US10112931, Example 418	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 16.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247813&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452077	346542352							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565188	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)c(C)c2)n1 |r|	InChI=1S/C20H21ClN6O4/c1-10-8-13(4-5-14(10)21)17-25-18(31-26-17)11(2)23-19-22-7-6-16(24-19)27-15(12(3)28)9-30-20(27)29/h4-8,11-12,15,28H,9H2,1-3H3,(H,22,23,24)	CTNWFAVTVAQWHU-UHFFFAOYSA-N	247814	US9688672, Example 419::US9434719, 419::US10112931, Example 419	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 96.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247814&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452079	346542353							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565189	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc(Cl)c(C)c2)n1 |r|	InChI=1S/C20H21ClN6O4/c1-10-8-13(4-5-14(10)21)17-25-18(31-26-17)11(2)23-19-22-7-6-16(24-19)27-15(12(3)28)9-30-20(27)29/h4-8,11-12,15,28H,9H2,1-3H3,(H,22,23,24)	CTNWFAVTVAQWHU-UHFFFAOYSA-N	247814	US9688672, Example 419::US9434719, 419::US10112931, Example 419	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 39.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247814&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452079	346542353							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565190	COc1cc(ccc1Br)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O |r|	InChI=1S/C20H21BrN6O5/c1-10(18-25-17(26-32-18)12-4-5-13(21)15(8-12)30-3)23-19-22-7-6-16(24-19)27-14(11(2)28)9-31-20(27)29/h4-8,10-11,14,28H,9H2,1-3H3,(H,22,23,24)	UFWGCYQKPCABFB-UHFFFAOYSA-N	247815	US9688672, Example 420::US9434719, 420::US10112931, Example 420	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 89.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247815	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247815&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452081	346542354							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565191	COc1cc(ccc1Br)-c1noc(n1)C(C)Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)O |r|	InChI=1S/C20H21BrN6O5/c1-10(18-25-17(26-32-18)12-4-5-13(21)15(8-12)30-3)23-19-22-7-6-16(24-19)27-14(11(2)28)9-31-20(27)29/h4-8,10-11,14,28H,9H2,1-3H3,(H,22,23,24)	UFWGCYQKPCABFB-UHFFFAOYSA-N	247815	US9688672, Example 420::US9434719, 420::US10112931, Example 420	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 47.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247815	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247815&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452081	346542354							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565192	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(c2)C(C)(C)C)n1 |r|	InChI=1S/C23H28N6O4/c1-13(20-27-19(28-33-20)15-7-6-8-16(11-15)23(3,4)5)25-21-24-10-9-18(26-21)29-17(14(2)30)12-32-22(29)31/h6-11,13-14,17,30H,12H2,1-5H3,(H,24,25,26)	PYBGXOXYGBVPRM-UHFFFAOYSA-N	247816	US9688672, Example 421::US9434719, 421::US10112931, Example 421	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 23.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247816&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452080	346542355							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565193	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2cccc(c2)C(C)(C)C)n1 |r|	InChI=1S/C23H28N6O4/c1-13(20-27-19(28-33-20)15-7-6-8-16(11-15)23(3,4)5)25-21-24-10-9-18(26-21)29-17(14(2)30)12-32-22(29)31/h6-11,13-14,17,30H,12H2,1-5H3,(H,24,25,26)	PYBGXOXYGBVPRM-UHFFFAOYSA-N	247816	US9688672, Example 421::US9434719, 421::US10112931, Example 421	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 21.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247816&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452080	346542355							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565194	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc3CCCc3c2)n1 |r|	InChI=1S/C22H24N6O4/c1-12(20-26-19(27-32-20)16-7-6-14-4-3-5-15(14)10-16)24-21-23-9-8-18(25-21)28-17(13(2)29)11-31-22(28)30/h6-10,12-13,17,29H,3-5,11H2,1-2H3,(H,23,24,25)	BOZGVLGFGSEXBU-UHFFFAOYSA-N	247817	US9688672, Example 423::US9434719, 423::US10112931, Example 423	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1760					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247817&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452082	346542356							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565195	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2nc(no2)-c2ccc3CCCc3c2)n1 |r|	InChI=1S/C22H24N6O4/c1-12(20-26-19(27-32-20)16-7-6-14-4-3-5-15(14)10-16)24-21-23-9-8-18(25-21)28-17(13(2)29)11-31-22(28)30/h6-10,12-13,17,29H,3-5,11H2,1-2H3,(H,23,24,25)	BOZGVLGFGSEXBU-UHFFFAOYSA-N	247817	US9688672, Example 423::US9434719, 423::US10112931, Example 423	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 36.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247817&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452082	346542356							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565196	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2noc(n2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C19H19ClN6O4/c1-10(16-24-17(30-25-16)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	HQFBCUBMPLPKFP-UHFFFAOYSA-N	247818	US9688672, Example 425::US9434719, 425::US10112931, Example 425	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7710					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247818&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414634	346542357							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565197	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2noc(n2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C19H19ClN6O4/c1-10(16-24-17(30-25-16)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	HQFBCUBMPLPKFP-UHFFFAOYSA-N	247818	US9688672, Example 425::US9434719, 425::US10112931, Example 425	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 6429					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247818&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414634	346542357							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565198	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2noc(n2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C19H19ClN6O4/c1-10(16-24-17(30-25-16)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	HQFBCUBMPLPKFP-UHFFFAOYSA-N	247818	US9688672, Example 425::US9434719, 425::US10112931, Example 425	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 303					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247818&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414634	346542357							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565199	C[C@@H](O)[C@H]1COC(=O)N1c1ccnc(NC(C)c2noc(n2)-c2ccc(Cl)cc2)n1 |r|	InChI=1S/C19H19ClN6O4/c1-10(16-24-17(30-25-16)12-3-5-13(20)6-4-12)22-18-21-8-7-15(23-18)26-14(11(2)27)9-29-19(26)28/h3-8,10-11,14,27H,9H2,1-2H3,(H,21,22,23)	HQFBCUBMPLPKFP-UHFFFAOYSA-N	247818	US9688672, Example 425::US9434719, 425::US10112931, Example 425	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 202					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247818&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414634	346542357							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565200	C[C@H](Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1cn(cn1)-c1ccc(Cl)cc1 |r|	InChI=1S/C21H21ClF2N6O2/c1-12(19(23)24)17-10-32-21(31)30(17)18-7-8-25-20(28-18)27-13(2)16-9-29(11-26-16)15-5-3-14(22)4-6-15/h3-9,11-13,17,19H,10H2,1-2H3,(H,25,27,28)	ISURFSGOOSPXEW-UHFFFAOYSA-N	247819	US9688672, Example 426::US9434719, 426 as TFA salt::US10112931, Example 426	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<15.9					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247819&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86270012	346542358							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565201	C[C@H](Nc1nccc(n1)N1[C@H](COC1=O)[C@@H](C)C(F)F)c1cn(cn1)-c1ccc(F)cc1 |r|	InChI=1S/C21H21F3N6O2/c1-12(19(23)24)17-10-32-21(31)30(17)18-7-8-25-20(28-18)27-13(2)16-9-29(11-26-16)15-5-3-14(22)4-6-15/h3-9,11-13,17,19H,10H2,1-2H3,(H,25,27,28)	DKEIWINCRUGBON-UHFFFAOYSA-N	247820	US9688672, Example 427::US9434719, 427 as TFA salt::US10112931, Example 427	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 39.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247820&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414508	346542359							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565202	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cnc(s2)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C20H18F4N6O2S/c1-10(21)13-9-32-19(31)30(13)16-4-6-26-18(29-16)28-11(2)14-8-27-17(33-14)12-3-5-25-15(7-12)20(22,23)24/h3-8,10-11,13H,9H2,1-2H3,(H,26,28,29)	WGHDFKRAKKPLGU-UHFFFAOYSA-N	247821	US9434719, 428 as TFA salt::US10112931, Example 428	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 67.8					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247821&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452083	346542360							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565203	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(Cl)cc1 |r|	InChI=1S/C19H17ClF2N6O2/c1-11(16-8-27(10-24-16)13-4-2-12(20)3-5-13)25-18-23-7-15(22)17(26-18)28-14(6-21)9-30-19(28)29/h2-5,7-8,10-11,14H,6,9H2,1H3,(H,23,25,26)	RRSNVVPVDMADPO-UHFFFAOYSA-N	247822	US9688672, Example 429::US9434719, 429::US10112931, Example 429	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247822	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247822&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452084	346542361							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565204	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(F)cc1 |r|	InChI=1S/C19H17F3N6O2/c1-11(16-8-27(10-24-16)13-4-2-12(21)3-5-13)25-18-23-7-15(22)17(26-18)28-14(6-20)9-30-19(28)29/h2-5,7-8,10-11,14H,6,9H2,1H3,(H,23,25,26)	GXKZHLYWKDTOMF-UHFFFAOYSA-N	247823	US9688672, Example 430::US9434719, 430 as TFA salt::US10112931, Example 430	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 50.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247823	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247823&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452085	346542362							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565205	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(F)c(F)c1 |r|	InChI=1S/C19H16F4N6O2/c1-10(16-7-28(9-25-16)11-2-3-13(21)14(22)4-11)26-18-24-6-15(23)17(27-18)29-12(5-20)8-31-19(29)30/h2-4,6-7,9-10,12H,5,8H2,1H3,(H,24,26,27)	VOPIQBRBHXRUFL-UHFFFAOYSA-N	247824	US9688672, Example 431::US9434719, 431 as TFA salt::US10112931, Example 431	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 47.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247824	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247824&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452086	346542363							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565206	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(Cl)c(F)c1 |r|	InChI=1S/C19H16ClF3N6O2/c1-10(16-7-28(9-25-16)11-2-3-13(20)14(22)4-11)26-18-24-6-15(23)17(27-18)29-12(5-21)8-31-19(29)30/h2-4,6-7,9-10,12H,5,8H2,1H3,(H,24,26,27)	RJKUDZZRLBWLPG-UHFFFAOYSA-N	247825	US9688672, Example 432::US9434719, 432 as TFA salt::US10112931, Example 432	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 16.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247825	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247825&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452087	346542364							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565207	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(F)c(Cl)c1 |r|	InChI=1S/C19H16ClF3N6O2/c1-10(16-7-28(9-25-16)11-2-3-14(22)13(20)4-11)26-18-24-6-15(23)17(27-18)29-12(5-21)8-31-19(29)30/h2-4,6-7,9-10,12H,5,8H2,1H3,(H,24,26,27)	NVVSKMGWOOUBRS-UHFFFAOYSA-N	247826	US9688672, Example 472::US9434719, 472 as TFA salt::US9434719, 433 as TFA salt::US10112931, Example 472	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 32.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247826&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415023	346542365							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565208	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(cc1)C(F)F |r|	InChI=1S/C20H18F4N6O2/c1-11(16-8-29(10-26-16)13-4-2-12(3-5-13)17(23)24)27-19-25-7-15(22)18(28-19)30-14(6-21)9-32-20(30)31/h2-5,7-8,10-11,14,17H,6,9H2,1H3,(H,25,27,28)	LNZPECKHDHOCTH-UHFFFAOYSA-N	247827	US9688672, Example 434::US9434719, 434 as TFA salt::US10112931, Example 434	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247827	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247827&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452088	346542366							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565209	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(C(F)F)c(F)c1 |r|	InChI=1S/C20H17F5N6O2/c1-10(16-7-30(9-27-16)11-2-3-13(17(24)25)14(22)4-11)28-19-26-6-15(23)18(29-19)31-12(5-21)8-33-20(31)32/h2-4,6-7,9-10,12,17H,5,8H2,1H3,(H,26,28,29)	YEEAJLVWHWXJEY-UHFFFAOYSA-N	247828	US9688672, Example 435::US9434719, 435 as TFA salt::US10112931, Example 435	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247828&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452089	346542367							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565210	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1cc(F)cc(F)c1 |r|	InChI=1S/C19H16F4N6O2/c1-10(16-7-28(9-25-16)13-3-11(21)2-12(22)4-13)26-18-24-6-15(23)17(27-18)29-14(5-20)8-31-19(29)30/h2-4,6-7,9-10,14H,5,8H2,1H3,(H,24,26,27)	JWXZESLECHVDLG-UHFFFAOYSA-N	247829	US9688672, Example 436::US9434719, 436 as TFA salt::US10112931, Example 436	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 60.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247829&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452090	346542368							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565211	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cc(on1)-c1ccc(Cl)cc1 |r|	InChI=1S/C19H16ClF2N5O3/c1-10(15-6-16(30-26-15)11-2-4-12(20)5-3-11)24-18-23-8-14(22)17(25-18)27-13(7-21)9-29-19(27)28/h2-6,8,10,13H,7,9H2,1H3,(H,23,24,25)	AEANJYOKYOSHMJ-UHFFFAOYSA-N	247830	US9688672, Example 437::US9434719, 437 as TFA salt::US10112931, Example 437	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 36.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247830	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247830&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452091	346542369							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565212	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cnc(s1)-c1ccc(Cl)cc1 |r|	InChI=1S/C19H16ClF2N5O2S/c1-10(15-8-23-17(30-15)11-2-4-12(20)5-3-11)25-18-24-7-14(22)16(26-18)27-13(6-21)9-29-19(27)28/h2-5,7-8,10,13H,6,9H2,1H3,(H,24,25,26)	JTVBEMFJLCUDSF-UHFFFAOYSA-N	247831	US9688672, Example 438::US9434719, 438 as TFA salt::US10112931, Example 438	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 45.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247831	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247831&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452092	346542370							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565213	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(c(C)n1)-c1ccc(Cl)cc1 |r|	InChI=1S/C20H19ClF2N6O2/c1-11(17-9-28(12(2)26-17)14-5-3-13(21)4-6-14)25-19-24-8-16(23)18(27-19)29-15(7-22)10-31-20(29)30/h3-6,8-9,11,15H,7,10H2,1-2H3,(H,24,25,27)	KKBKZLBPYXMPHF-UHFFFAOYSA-N	247832	US9688672, Example 439::US9434719, 439 as TFA salt::US10112931, Example 439	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 392					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247832&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452093	346542371							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565214	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccnc(c1)C(F)(F)F |r|	InChI=1S/C19H16F5N7O2/c1-10(14-7-30(9-27-14)11-2-3-25-15(4-11)19(22,23)24)28-17-26-6-13(21)16(29-17)31-12(5-20)8-33-18(31)32/h2-4,6-7,9-10,12H,5,8H2,1H3,(H,26,28,29)	XJNZVNWEFMYLJC-UHFFFAOYSA-N	296089	US10112931, Example 440	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 172					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=296089	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=296089&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			134271971	381619039							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565215	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cc(F)c(cc1F)-c1ccnc(C)c1 |r|	InChI=1S/C22H19F4N5O2/c1-11-5-13(3-4-27-11)16-7-17(24)15(6-18(16)25)12(2)29-21-28-9-19(26)20(30-21)31-14(8-23)10-33-22(31)32/h3-7,9,12,14H,8,10H2,1-2H3,(H,28,29,30)	QUJSQKQTOGJSQE-UHFFFAOYSA-N	247834	US9688672, Example 441::US9434719, 441 as TFA salt::US10112931, Example 441	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247834&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452095	346542373							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565216	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cc(F)c(cc1F)-c1ccc(C)nc1 |r|	InChI=1S/C22H19F4N5O2/c1-11-3-4-13(8-27-11)16-6-17(24)15(5-18(16)25)12(2)29-21-28-9-19(26)20(30-21)31-14(7-23)10-33-22(31)32/h3-6,8-9,12,14H,7,10H2,1-2H3,(H,28,29,30)	ZTPQMXHQHNRVHT-UHFFFAOYSA-N	247835	US9688672, Example 442::US9434719, 442 as TFA salt::US10112931, Example 442	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 38.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247835&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452096	346542374							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565217	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cc(F)c(cc1F)-c1ccc(nc1)C(F)(F)F |r|	InChI=1S/C22H16F7N5O2/c1-10(32-20-31-8-17(26)19(33-20)34-12(6-23)9-36-21(34)35)13-4-16(25)14(5-15(13)24)11-2-3-18(30-7-11)22(27,28)29/h2-5,7-8,10,12H,6,9H2,1H3,(H,31,32,33)	UJHALGOXSDSNLN-UHFFFAOYSA-N	247836	US9688672, Example 443::US9434719, 443 as TFA salt::US10112931, Example 443	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247836	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247836&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452097	346542375							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565218	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cc(F)c(cc1F)-c1ccnc(c1)C(F)(F)F |r|	InChI=1S/C22H16F7N5O2/c1-10(32-20-31-8-17(26)19(33-20)34-12(7-23)9-36-21(34)35)13-5-16(25)14(6-15(13)24)11-2-3-30-18(4-11)22(27,28)29/h2-6,8,10,12H,7,9H2,1H3,(H,31,32,33)	BUQIWBTXPVHMKM-UHFFFAOYSA-N	247837	US9688672, Example 444::US9434719, 444 as TFA salt::US10112931, Example 444	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247837&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452098	346542376							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565219	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cc(F)c(cc1F)-n1cnc(C)c1 |r|	InChI=1S/C20H18F4N6O2/c1-10-7-29(9-26-10)17-4-14(22)13(3-15(17)23)11(2)27-19-25-6-16(24)18(28-19)30-12(5-21)8-32-20(30)31/h3-4,6-7,9,11-12H,5,8H2,1-2H3,(H,25,27,28)	WWELKOSMVLYQSW-UHFFFAOYSA-N	247838	US9688672, Example 445::US9434719, 445 as TFA salt::US10112931, Example 445	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 112					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247838&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452099	346542377							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565220	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(C(F)F)c(F)c2)ncc1F |r|	InChI=1S/C21H19F5N6O2/c1-10(22)17-8-34-21(33)32(17)19-15(24)6-27-20(30-19)29-11(2)16-7-31(9-28-16)12-3-4-13(18(25)26)14(23)5-12/h3-7,9-11,17-18H,8H2,1-2H3,(H,27,29,30)	BRHQSNMICOTJLU-UHFFFAOYSA-N	247839	US9688672, Example 446::US9434719, 446 as TFA salt::US10112931, Example 446	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 26.8					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247839&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454455	346542378							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565221	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(cc2)C(F)F)ncc1F |r|	InChI=1S/C21H20F4N6O2/c1-11(22)17-9-33-21(32)31(17)19-15(23)7-26-20(29-19)28-12(2)16-8-30(10-27-16)14-5-3-13(4-6-14)18(24)25/h3-8,10-12,17-18H,9H2,1-2H3,(H,26,28,29)	YZTROUKWLNOSAK-UHFFFAOYSA-N	247840	US9688672, Example 447::US9434719, 447 as TFA salt::US10112931, Example 447	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 28.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247840&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454433	346542379							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565222	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)c(F)c2)ncc1F |r|	InChI=1S/C20H18ClF3N6O2/c1-10(22)17-8-32-20(31)30(17)18-15(24)6-25-19(28-18)27-11(2)16-7-29(9-26-16)12-3-4-13(21)14(23)5-12/h3-7,9-11,17H,8H2,1-2H3,(H,25,27,28)	BWMXYVHTSYLXNW-UHFFFAOYSA-N	247841	US9688672, Example 448::US9434719, 448 as TFA salt::US10112931, Example 448	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247841&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454343	346542380							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565223	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2cc(F)cc(F)c2)ncc1F |r|	InChI=1S/C20H18F4N6O2/c1-10(21)17-8-32-20(31)30(17)18-15(24)6-25-19(28-18)27-11(2)16-7-29(9-26-16)14-4-12(22)3-13(23)5-14/h3-7,9-11,17H,8H2,1-2H3,(H,25,27,28)	SHUACSXYCKAFCG-UHFFFAOYSA-N	247842	US9688672, Example 449::US9434719, 449 as TFA salt::US10112931, Example 449	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29.7					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247842&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454357	346542381							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565224	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H19ClF2N6O2/c1-11(22)17-9-31-20(30)29(17)18-15(23)7-24-19(27-18)26-12(2)16-8-28(10-25-16)14-5-3-13(21)4-6-14/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)	TXJIZORMCOMGCK-UHFFFAOYSA-N	247843	US9688672, Example 450::US9434719, 450 as TFA salt::US10112931, Example 450	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247843&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454346	346542382							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565225	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(F)cc2)ncc1F |r|	InChI=1S/C20H19F3N6O2/c1-11(21)17-9-31-20(30)29(17)18-15(23)7-24-19(27-18)26-12(2)16-8-28(10-25-16)14-5-3-13(22)4-6-14/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)	XSQQJNHGJYGXLX-UHFFFAOYSA-N	247844	US9688672, Example 451::US9434719, 451 as TFA salt::US10112931, Example 451	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 43.5					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247844&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454320	346542383							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565226	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(on2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H18ClF2N5O3/c1-10(22)16-9-30-20(29)28(16)18-14(23)8-24-19(26-18)25-11(2)15-7-17(31-27-15)12-3-5-13(21)6-4-12/h3-8,10-11,16H,9H2,1-2H3,(H,24,25,26)	KPUWPLMVSGVTML-UHFFFAOYSA-N	247845	US9688672, Example 452::US9434719, 452 as TFA salt::US10112931, Example 452	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 29.3					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247845&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454348	346542384							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565227	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cnn(c2)-c2ccc(Cl)cc2)ncc1F |r|	InChI=1S/C20H19ClF2N6O2/c1-11(22)17-10-31-20(30)29(17)18-16(23)8-24-19(27-18)26-12(2)13-7-25-28(9-13)15-5-3-14(21)4-6-15/h3-9,11-12,17H,10H2,1-2H3,(H,24,26,27)	YFWQMXWNYLZFPV-UHFFFAOYSA-N	247846	US9688672, Example 453::US9434719, 453 as TFA salt::US10112931, Example 453	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 35.7					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247846&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454344	346542385							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565228	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2cc(F)cc(F)c2)n1 |r|	InChI=1S/C20H19F3N6O2/c1-11(21)17-9-31-20(30)29(17)18-3-4-24-19(27-18)26-12(2)16-8-28(10-25-16)15-6-13(22)5-14(23)7-15/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)	XXNNSQAHQANGNY-UHFFFAOYSA-N	247847	US9688672, Example 454::US9434719, 454 as TFA salt::US10112931, Example 454	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 23.4					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247847&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454345	346542386							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565229	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(C(F)F)c(F)c2)n1 |r|	InChI=1S/C21H20F4N6O2/c1-11(22)17-9-33-21(32)31(17)18-5-6-26-20(29-18)28-12(2)16-8-30(10-27-16)13-3-4-14(19(24)25)15(23)7-13/h3-8,10-12,17,19H,9H2,1-2H3,(H,26,28,29)	NAOADSREFWJWOH-UHFFFAOYSA-N	247848	US9688672, Example 455::US9434719, 455 as TFA salt::US10112931, Example 455	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247848	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247848&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454425	346542387							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565230	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(cc2)C(F)F)n1 |r|	InChI=1S/C21H21F3N6O2/c1-12(22)17-10-32-21(31)30(17)18-7-8-25-20(28-18)27-13(2)16-9-29(11-26-16)15-5-3-14(4-6-15)19(23)24/h3-9,11-13,17,19H,10H2,1-2H3,(H,25,27,28)	RJYKUROAIMWHTJ-UHFFFAOYSA-N	247849	US9688672, Example 456::US9434719, 456::US10112931, Example 456	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247849&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454349	346542388							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565231	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(cc2)C(F)F)n1 |r|	InChI=1S/C21H21F3N6O2/c1-12(22)17-10-32-21(31)30(17)18-7-8-25-20(28-18)27-13(2)16-9-29(11-26-16)15-5-3-14(4-6-15)19(23)24/h3-9,11-13,17,19H,10H2,1-2H3,(H,25,27,28)	RJYKUROAIMWHTJ-UHFFFAOYSA-N	247849	US9688672, Example 456::US9434719, 456::US10112931, Example 456	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1.000					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247849&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454349	346542388							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565232	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(F)c(Cl)c2)n1 |r|	InChI=1S/C20H19ClF2N6O2/c1-11(22)17-9-31-20(30)29(17)18-5-6-24-19(27-18)26-12(2)16-8-28(10-25-16)13-3-4-15(23)14(21)7-13/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)	SUNCNPZABKTXGR-UHFFFAOYSA-N	247850	US9688672, Example 457::US9434719, 457 as TFA salt::US10112931, Example 457	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247850&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454350	346542389							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565233	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)c(F)c2)n1 |r|	InChI=1S/C20H19ClF2N6O2/c1-11(22)17-9-31-20(30)29(17)18-5-6-24-19(27-18)26-12(2)16-8-28(10-25-16)13-3-4-14(21)15(23)7-13/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)	VTNGUBXZQCZZRS-UHFFFAOYSA-N	247851	US9688672, Example 458::US9434719, 458 as TFA salt::US10112931, Example 458	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<16.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247851&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454319	346542390							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565234	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(F)c(F)c2)n1 |r|	InChI=1S/C20H19F3N6O2/c1-11(21)17-9-31-20(30)29(17)18-5-6-24-19(27-18)26-12(2)16-8-28(10-25-16)13-3-4-14(22)15(23)7-13/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)	BVIGUFPJCYRDKX-UHFFFAOYSA-N	247852	US9688672, Example 459::US9434719, 459 as TFA salt::US10112931, Example 459	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 24.6					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247852&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454359	346542391							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565235	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(F)c(cc2F)-c2cnn(C)c2)n1 |r|	InChI=1S/C21H21F3N6O2/c1-11(22)18-10-32-21(31)30(18)19-4-5-25-20(28-19)27-12(2)14-6-17(24)15(7-16(14)23)13-8-26-29(3)9-13/h4-9,11-12,18H,10H2,1-3H3,(H,25,27,28)	PRQTXEWKEGXZSP-UHFFFAOYSA-N	247853	US9688672, Example 460::US9434719, 460 as TFA salt::US10112931, Example 460	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 24.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247853&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90454347	346542392							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565236	C[C@@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(F)cc2)ncc1F |r|	InChI=1S/C20H19F3N6O2/c1-11(21)17-9-31-20(30)29(17)18-15(23)7-24-19(27-18)26-12(2)16-8-28(10-25-16)14-5-3-13(22)4-6-14/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)	XSQQJNHGJYGXLX-UHFFFAOYSA-N	247854	US9688672, Example 461::US9434719, 461 as TFA salt::US10112931, Example 461	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 45.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247854&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452100	346542393							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565237	C[C@@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ncc(cc2F)-c2ccnc(c2)C(F)(F)F)ncc1F |r|	InChI=1S/C22H18F6N6O2/c1-10(23)16-9-36-21(35)34(16)19-15(25)8-31-20(33-19)32-11(2)18-14(24)5-13(7-30-18)12-3-4-29-17(6-12)22(26,27)28/h3-8,10-11,16H,9H2,1-2H3,(H,31,32,33)	RZJWJDQMMZKFDZ-UHFFFAOYSA-N	247855	US9688672, Example 462::US9434719, 462 as TFA salt::US10112931, Example 462	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 73.8					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247855&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452101	346542394							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565238	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cc2F)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C22H19F5N6O2/c1-11(23)16-10-35-21(34)33(16)18-4-6-29-20(32-18)31-12(2)19-15(24)7-14(9-30-19)13-3-5-28-17(8-13)22(25,26)27/h3-9,11-12,16H,10H2,1-2H3,(H,29,31,32)	IOIQVLOYWKIJAZ-UHFFFAOYSA-N	247856	US9688672, Example 463::US9434719, 463::US10112931, Example 463	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 38.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247856&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452102	346542395							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565239	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cc2F)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C22H19F5N6O2/c1-11(23)16-10-35-21(34)33(16)18-4-6-29-20(32-18)31-12(2)19-15(24)7-14(9-30-19)13-3-5-28-17(8-13)22(25,26)27/h3-9,11-12,16H,10H2,1-2H3,(H,29,31,32)	IOIQVLOYWKIJAZ-UHFFFAOYSA-N	247856	US9688672, Example 463::US9434719, 463::US10112931, Example 463	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10.00					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247856&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452102	346542395							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565240	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cc2F)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C22H19F5N6O2/c1-11(23)16-10-35-21(34)33(16)18-4-6-29-20(32-18)31-12(2)19-15(24)7-14(9-30-19)13-3-5-28-17(8-13)22(25,26)27/h3-9,11-12,16H,10H2,1-2H3,(H,29,31,32)	IOIQVLOYWKIJAZ-UHFFFAOYSA-N	247856	US9688672, Example 463::US9434719, 463::US10112931, Example 463	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 35.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247856&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452102	346542395							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565241	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cc2F)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C22H19F5N6O2/c1-11(23)16-10-35-21(34)33(16)18-4-6-29-20(32-18)31-12(2)19-15(24)7-14(9-30-19)13-3-5-28-17(8-13)22(25,26)27/h3-9,11-12,16H,10H2,1-2H3,(H,29,31,32)	IOIQVLOYWKIJAZ-UHFFFAOYSA-N	247856	US9688672, Example 463::US9434719, 463::US10112931, Example 463	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 39.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247856&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452102	346542395							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565242	C[C@@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cc2F)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C22H19F5N6O2/c1-11(23)16-10-35-21(34)33(16)18-4-6-29-20(32-18)31-12(2)19-15(24)7-14(9-30-19)13-3-5-28-17(8-13)22(25,26)27/h3-9,11-12,16H,10H2,1-2H3,(H,29,31,32)	IOIQVLOYWKIJAZ-UHFFFAOYSA-N	247857	US9688672, Example 464::US9434719, 464 as TFA salt::US10112931, Example 464	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 93.7					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247857&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452103	346542396							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565243	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2ncc(cc2F)-c2ccnc(c2)C(F)(F)F)ncc1F |r|	InChI=1S/C22H18F6N6O2/c1-10(23)16-9-36-21(35)34(16)19-15(25)8-31-20(33-19)32-11(2)18-14(24)5-13(7-30-18)12-3-4-29-17(6-12)22(26,27)28/h3-8,10-11,16H,9H2,1-2H3,(H,31,32,33)	RZJWJDQMMZKFDZ-UHFFFAOYSA-N	247858	US9688672, Example 465::US9434719, 465 as TFA salt::US10112931, Example 465	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 68.1					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247858&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90452104	346542397							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565244	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(C)c(cn2)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C23H22F4N6O2/c1-12-8-17(30-10-16(12)15-4-6-28-19(9-15)23(25,26)27)14(3)31-21-29-7-5-20(32-21)33-18(13(2)24)11-35-22(33)34/h4-10,13-14,18H,11H2,1-3H3,(H,29,31,32)	DCGDPJCUIKLTDU-UHFFFAOYSA-N	247859	US9688672, Example 466::US9434719, 466::US10112931, Example 466	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 24.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247859&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415637	346542398							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565245	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc(C)c(cn2)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C23H22F4N6O2/c1-12-8-17(30-10-16(12)15-4-6-28-19(9-15)23(25,26)27)14(3)31-21-29-7-5-20(32-21)33-18(13(2)24)11-35-22(33)34/h4-10,13-14,18H,11H2,1-3H3,(H,29,31,32)	DCGDPJCUIKLTDU-UHFFFAOYSA-N	247859	US9688672, Example 466::US9434719, 466::US10112931, Example 466	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 11.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247859&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415637	346542398							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565246	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cn2)-c2cccc(c2F)C(F)(F)F)n1 |r|	InChI=1S/C22H19F5N6O2/c1-11(23)16-10-35-21(34)33(16)17-6-7-28-20(32-17)31-12(2)19-29-8-13(9-30-19)14-4-3-5-15(18(14)24)22(25,26)27/h3-9,11-12,16H,10H2,1-2H3,(H,28,31,32)	GRLDXWXKPBGGFY-UHFFFAOYSA-N	296116	US10112931, Example 467::(R)-3-(2-(((S)-1-(5-(2-fluoro-3-(trifluoromethyl)phenyl)pyrimidin-2-yl)ethyl)amino)pyrimidin-4-yl)-4-((S)-1-fluoroethyl)oxazolidin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 8.00					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=296116	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=296116&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416567	381619066							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565247	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cn2)-c2cccc(c2F)C(F)(F)F)n1 |r|	InChI=1S/C22H19F5N6O2/c1-11(23)16-10-35-21(34)33(16)17-6-7-28-20(32-17)31-12(2)19-29-8-13(9-30-19)14-4-3-5-15(18(14)24)22(25,26)27/h3-9,11-12,16H,10H2,1-2H3,(H,28,31,32)	GRLDXWXKPBGGFY-UHFFFAOYSA-N	296116	US10112931, Example 467::(R)-3-(2-(((S)-1-(5-(2-fluoro-3-(trifluoromethyl)phenyl)pyrimidin-2-yl)ethyl)amino)pyrimidin-4-yl)-4-((S)-1-fluoroethyl)oxazolidin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<2.29					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=296116	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=296116&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416567	381619066							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565248	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C22H20F4N6O2/c1-12(23)17-11-34-21(33)32(17)19-6-8-28-20(31-19)30-13(2)16-4-3-15(10-29-16)14-5-7-27-18(9-14)22(24,25)26/h3-10,12-13,17H,11H2,1-2H3,(H,28,30,31)	CRWAIFFIPSZEKI-UHFFFAOYSA-N	247861	US9688672, Example 468::US9434719, 468::US10112931, Example 468	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 128					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247861&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416189	346542400							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565249	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cn2)-c2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C22H20F4N6O2/c1-12(23)17-11-34-21(33)32(17)19-6-8-28-20(31-19)30-13(2)16-4-3-15(10-29-16)14-5-7-27-18(9-14)22(24,25)26/h3-10,12-13,17H,11H2,1-2H3,(H,28,30,31)	CRWAIFFIPSZEKI-UHFFFAOYSA-N	247861	US9688672, Example 468::US9434719, 468::US10112931, Example 468	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 23.0					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247861&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416189	346542400							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565250	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cn2)-c2ccc(F)c(C)c2)n1 |r|	InChI=1S/C22H22F2N6O2/c1-12-8-15(4-5-17(12)24)16-9-26-20(27-10-16)14(3)28-21-25-7-6-19(29-21)30-18(13(2)23)11-32-22(30)31/h4-10,13-14,18H,11H2,1-3H3,(H,25,28,29)	RYLRLADEFFZKLS-UHFFFAOYSA-N	247862	US9688672, Example 469::US9434719, 469::US10112931, Example 469	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247862&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416226	346542401							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565251	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cc(C)c(cn2)-c2ccnc(c2)C(F)(F)F)ncc1F |r|	InChI=1S/C23H21F5N6O2/c1-11-6-17(30-8-15(11)14-4-5-29-19(7-14)23(26,27)28)13(3)32-21-31-9-16(25)20(33-21)34-18(12(2)24)10-36-22(34)35/h4-9,12-13,18H,10H2,1-3H3,(H,31,32,33)	GRPUGQNJIJGTSU-UHFFFAOYSA-N	247863	US9434719, 470::US10112931, Example 470	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12.8					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247863&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416554	346542402							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565252	C[C@H](Nc1nccc(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(F)cc1 |r|	InChI=1S/C19H18F2N6O2/c1-12(16-9-26(11-23-16)14-4-2-13(21)3-5-14)24-18-22-7-6-17(25-18)27-15(8-20)10-29-19(27)28/h2-7,9,11-12,15H,8,10H2,1H3,(H,22,24,25)	MUJQDKNKSGDIBR-UHFFFAOYSA-N	247864	US9688672, Example 471::US9434719, 471 as TFA salt::US10112931, Example 471	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 49.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247864&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90417235	346542403							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565253	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(F)c(Cl)c1 |r|	InChI=1S/C19H16ClF3N6O2/c1-10(16-7-28(9-25-16)11-2-3-14(22)13(20)4-11)26-18-24-6-15(23)17(27-18)29-12(5-21)8-31-19(29)30/h2-4,6-7,9-10,12H,5,8H2,1H3,(H,24,26,27)	NVVSKMGWOOUBRS-UHFFFAOYSA-N	247826	US9688672, Example 472::US9434719, 472 as TFA salt::US9434719, 433 as TFA salt::US10112931, Example 472	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 32.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247826&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415023	346542365							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565254	C[C@H](Nc1nccc(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(Cl)c(F)c1 |r|	InChI=1S/C19H17ClF2N6O2/c1-11(16-8-27(10-24-16)12-2-3-14(20)15(22)6-12)25-18-23-5-4-17(26-18)28-13(7-21)9-30-19(28)29/h2-6,8,10-11,13H,7,9H2,1H3,(H,23,25,26)	KAGPKBJIFWYNFG-UHFFFAOYSA-N	247866	US9688672, Example 473::US9434719, 473 as TFA salt::US10112931, Example 473	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 19.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247866&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416762	346542404							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565255	C[C@H](Nc1nccc(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(F)c(F)c1 |r|	InChI=1S/C19H17F3N6O2/c1-11(16-8-27(10-24-16)12-2-3-14(21)15(22)6-12)25-18-23-5-4-17(26-18)28-13(7-20)9-30-19(28)29/h2-6,8,10-11,13H,7,9H2,1H3,(H,23,25,26)	CCFPSGAPMCORJU-UHFFFAOYSA-N	247867	US9688672, Example 474::US9434719, 474 as TFA salt::US10112931, Example 474	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 77.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247867&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90417093	346542405							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565256	C[C@H](Nc1nccc(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(C(F)F)c(F)c1 |r|	InChI=1S/C20H18F4N6O2/c1-11(16-8-29(10-26-16)12-2-3-14(18(23)24)15(22)6-12)27-19-25-5-4-17(28-19)30-13(7-21)9-32-20(30)31/h2-6,8,10-11,13,18H,7,9H2,1H3,(H,25,27,28)	KQAQIPGOQYGYGU-UHFFFAOYSA-N	247868	US9688672, Example 475::US9434719, 475 as TFA salt::US10112931, Example 475	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 22.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247868&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414573	346542406							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565257	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2F)n1 |r|	InChI=1S/C20H19ClF2N6O2/c1-11(22)17-9-31-20(30)29(17)18-5-6-24-19(27-18)26-12(2)15-8-28(10-25-15)16-4-3-13(21)7-14(16)23/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)	GBVGVZWPJUJRID-UHFFFAOYSA-N	247869	US9688672, Example 476::US9434719, 476 as TFA salt::US10112931, Example 476	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247869&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90415785	346542407							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565258	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(Cl)cc2F)ncc1F |r|	InChI=1S/C20H18ClF3N6O2/c1-10(22)17-8-32-20(31)30(17)18-14(24)6-25-19(28-18)27-11(2)15-7-29(9-26-15)16-4-3-12(21)5-13(16)23/h3-7,9-11,17H,8H2,1-2H3,(H,25,27,28)	LOFZHNKWHDCFGV-UHFFFAOYSA-N	247870	US9688672, Example 477::US9434719, 477::US10112931, Example 477	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247870&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90417032	346542408							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565259	C[C@H](F)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(F)cc2F)n1 |r|	InChI=1S/C20H19F3N6O2/c1-11(21)17-9-31-20(30)29(17)18-5-6-24-19(27-18)26-12(2)15-8-28(10-25-15)16-4-3-13(22)7-14(16)23/h3-8,10-12,17H,9H2,1-2H3,(H,24,26,27)	QSXVHTSSRYSMHW-UHFFFAOYSA-N	247871	US9688672, Example 478::US9434719, 478 as TFA salt::US10112931, Example 478	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 51.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247871&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90414670	346542409							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565260	C[C@H](F)[C@H]1COC(=O)N1c1nc(N[C@@H](C)c2cn(cn2)-c2ccc(F)cc2F)ncc1F |r|	InChI=1S/C20H18F4N6O2/c1-10(21)17-8-32-20(31)30(17)18-14(24)6-25-19(28-18)27-11(2)15-7-29(9-26-15)16-4-3-12(22)5-13(16)23/h3-7,9-11,17H,8H2,1-2H3,(H,25,27,28)	JVMVIFQILNOBFI-UHFFFAOYSA-N	247872	US9688672, Example 479::US9434719, 479 as TFA salt::US10112931, Example 479	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 87.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247872&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90416756	346542410							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565261	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1ncc(o1)-c1ccc(Cl)cc1 |r|	InChI=1S/C19H16ClF2N5O3/c1-10(17-23-8-15(30-17)11-2-4-12(20)5-3-11)25-18-24-7-14(22)16(26-18)27-13(6-21)9-29-19(27)28/h2-5,7-8,10,13H,6,9H2,1H3,(H,24,25,26)	SDTNROJHSVEFHF-UHFFFAOYSA-N	247873	US9688672, Example 480::US9434719, 480::US10112931, Example 480	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 17.0					7.5000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795960	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247873&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90423199	346542411							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
565262	C[C@H](Nc1ncc(F)c(n1)N1[C@@H](CF)COC1=O)c1ncc(o1)-c1ccc(Cl)cc1 |r|	InChI=1S/C19H16ClF2N5O3/c1-10(17-23-8-15(30-17)11-2-4-12(20)5-3-11)25-18-24-7-14(22)16(26-18)27-13(6-21)9-29-19(27)28/h2-5,7-8,10,13H,6,9H2,1H3,(H,24,25,26)	SDTNROJHSVEFHF-UHFFFAOYSA-N	247873	US9688672, Example 480::US9434719, 480::US10112931, Example 480	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5.00					7.4000	25.00 C	US Patent		10.7270/Q2PG1TRT		aid1795961	US10112931	Caferro, TR; Chen, Z; Cho, YS; Costales, AQ; Levell, JR; Liu, G; Manning, JR; Sendzik, M; Shafer, C; Shultz, MD; Sutton, JC; Wang, Y; Zhao, Q	10/30/2018	3/4/2019	Novartis	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247873&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90423199	346542411							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580443	C[C@@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)noc1C |r|	InChI=1S/C28H31F3N4O2/c1-16-12-21(15-27(4,5)14-16)35-24-11-6-19(25-17(2)34-37-18(25)3)13-23(24)33-26(35)32-20-7-9-22(10-8-20)36-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)	NDUCHRAKQIXMCH-UHFFFAOYSA-N	303075	(+/1)5-(3,5-dimethyl-1,2-oxazol-4-yl)-N-[4-(trifluoromethoxy)phenyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-2-amine::US10137110, Example 2-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 120							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303075	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303075&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554279	381751810							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580444	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)noc1C |r|	InChI=1S/C28H31F3N4O2/c1-16-12-21(15-27(4,5)14-16)35-24-11-6-19(25-17(2)34-37-18(25)3)13-23(24)33-26(35)32-20-7-9-22(10-8-20)36-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)	NDUCHRAKQIXMCH-UHFFFAOYSA-N	303076	US10137110, Example 2-1-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 240							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303076	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303076&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363837	381751811							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580445	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)noc1C |r|	InChI=1S/C28H31F3N4O2/c1-16-12-21(15-27(4,5)14-16)35-24-11-6-19(25-17(2)34-37-18(25)3)13-23(24)33-26(35)32-20-7-9-22(10-8-20)36-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)	NDUCHRAKQIXMCH-UHFFFAOYSA-N	303077	US10137110, Example 2-1-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 70.0							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303077	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303077&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363872	381751812							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580446	C[C@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cccc(c1)C(O)=O |r|	InChI=1S/C30H30F3N3O3/c1-18-13-23(17-29(2,3)16-18)36-26-12-7-20(19-5-4-6-21(14-19)27(37)38)15-25(26)35-28(36)34-22-8-10-24(11-9-22)39-30(31,32)33/h4-12,14-15,18,23H,13,16-17H2,1-3H3,(H,34,35)(H,37,38)	DCLIXYJDCCEKAF-UHFFFAOYSA-N	303078	US10137110, Example 2-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 70.0							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303078	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303078&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554280	381751813							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580447	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1ccc(cc1)C(O)=O |r|	InChI=1S/C30H30F3N3O3/c1-18-14-23(17-29(2,3)16-18)36-26-13-8-21(19-4-6-20(7-5-19)27(37)38)15-25(26)35-28(36)34-22-9-11-24(12-10-22)39-30(31,32)33/h4-13,15,18,23H,14,16-17H2,1-3H3,(H,34,35)(H,37,38)	FCELCVUCPASMLD-UHFFFAOYSA-N	303079	US10137110, Example 2-3	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 460							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303079	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303079&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363853	381751814							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580448	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cn[nH]c1 |r|	InChI=1S/C26H28F3N5O/c1-16-10-20(13-25(2,3)12-16)34-23-9-4-17(18-14-30-31-15-18)11-22(23)33-24(34)32-19-5-7-21(8-6-19)35-26(27,28)29/h4-9,11,14-16,20H,10,12-13H2,1-3H3,(H,30,31)(H,32,33)	IFOCIVINXZHLNV-UHFFFAOYSA-N	303080	US10137110, Example 2-4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 80.0							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303080	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303080&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554281	381751815							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580449	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)n[nH]c1C |r|	InChI=1S/C28H32F3N5O/c1-16-12-21(15-27(4,5)14-16)36-24-11-6-19(25-17(2)34-35-18(25)3)13-23(24)33-26(36)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)(H,34,35)	YINXLLNIRQGDOR-UHFFFAOYSA-N	303081	US10137110, Example 2-5::BDBM303082	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 90.0							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303081	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303081&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554282	381751816							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580450	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)n[nH]c1C |r|	InChI=1S/C28H32F3N5O/c1-16-12-21(15-27(4,5)14-16)36-24-11-6-19(25-17(2)34-35-18(25)3)13-23(24)33-26(36)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)(H,34,35)	YINXLLNIRQGDOR-UHFFFAOYSA-N	303081	US10137110, Example 2-5::BDBM303082	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 670							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303081	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303081&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554282	381751816							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580451	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)n[nH]c1C |r|	InChI=1S/C28H32F3N5O/c1-16-12-21(15-27(4,5)14-16)36-24-11-6-19(25-17(2)34-35-18(25)3)13-23(24)33-26(36)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)(H,34,35)	YINXLLNIRQGDOR-UHFFFAOYSA-N	303083	US10137110, Example 2-5-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1540							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303083	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303083&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554283	381751818							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580452	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1c[nH]nc1C |r|	InChI=1S/C27H30F3N5O/c1-16-11-20(14-26(3,4)13-16)35-24-10-5-18(22-15-31-34-17(22)2)12-23(24)33-25(35)32-19-6-8-21(9-7-19)36-27(28,29)30/h5-10,12,15-16,20H,11,13-14H2,1-4H3,(H,31,34)(H,32,33)	KUFZBAQLEZABNJ-UHFFFAOYSA-N	303084	US10137110, Example 2-7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 110							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303084	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303084&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554284	381751819							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580453	C[C@H]5C[C@@H](n4c(Nc1ccc(OC(F)(F)F)cc1)nc3cc(c2ccn[nH]2)ccc34)CC(C)(C)C5	InChI=1S/C26H28F3N5O/c1-16-12-19(15-25(2,3)14-16)34-23-9-4-17(21-10-11-30-33-21)13-22(23)32-24(34)31-18-5-7-20(8-6-18)35-26(27,28)29/h4-11,13,16,19H,12,14-15H2,1-3H3,(H,30,33)(H,31,32)	PEEVXZMPBDEIMD-UHFFFAOYSA-N	303085	US10137110, Example 2-8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 130							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303085	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303085&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363892	381751820							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580454	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cnoc1 |r|	InChI=1S/C26H27F3N4O2/c1-16-10-20(13-25(2,3)12-16)33-23-9-4-17(18-14-30-34-15-18)11-22(23)32-24(33)31-19-5-7-21(8-6-19)35-26(27,28)29/h4-9,11,14-16,20H,10,12-13H2,1-3H3,(H,31,32)	JPUDOTIZBUNJRJ-UHFFFAOYSA-N	303086	US10137110, Example 2-9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 180							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303086	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303086&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132087292	381751821							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580455	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(SC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)n[nH]c1C |r|	InChI=1S/C28H32F3N5S/c1-16-12-21(15-27(4,5)14-16)36-24-11-6-19(25-17(2)34-35-18(25)3)13-23(24)33-26(36)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)(H,34,35)	DFBMMLUAYOCUSW-UHFFFAOYSA-N	303087	US10137110, Example 2-10::BDBM303088	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 140							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303087	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303087&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554285	381751822							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580456	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(SC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)n[nH]c1C |r|	InChI=1S/C28H32F3N5S/c1-16-12-21(15-27(4,5)14-16)36-24-11-6-19(25-17(2)34-35-18(25)3)13-23(24)33-26(36)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)(H,34,35)	DFBMMLUAYOCUSW-UHFFFAOYSA-N	303087	US10137110, Example 2-10::BDBM303088	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 300							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303087	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303087&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554285	381751822							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580457	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(SC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)n[nH]c1C |r|	InChI=1S/C28H32F3N5S/c1-16-12-21(15-27(4,5)14-16)36-24-11-6-19(25-17(2)34-35-18(25)3)13-23(24)33-26(36)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)(H,34,35)	DFBMMLUAYOCUSW-UHFFFAOYSA-N	303089	US10137110, Example 2-10-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 140							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303089	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303089&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554286	381751824							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580458	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cccc(c1)C(N)=O |r|	InChI=1S/C30H31F3N4O2/c1-18-13-23(17-29(2,3)16-18)37-26-12-7-20(19-5-4-6-21(14-19)27(34)38)15-25(26)36-28(37)35-22-8-10-24(11-9-22)39-30(31,32)33/h4-12,14-15,18,23H,13,16-17H2,1-3H3,(H2,34,38)(H,35,36)	DLQKRKOXZUBFMG-UHFFFAOYSA-N	303090	US10137110, Example 2-11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 210							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303090	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303090&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363913	381751825							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580459	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cc(C)nn1C |r|	InChI=1S/C28H32F3N5O/c1-17-12-21(16-27(3,4)15-17)36-24-11-6-19(25-13-18(2)34-35(25)5)14-23(24)33-26(36)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13-14,17,21H,12,15-16H2,1-5H3,(H,32,33)	JDEHFVUWCKSVCS-UHFFFAOYSA-N	303091	US10137110, Example 2-12::BDBM303092	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 100.0							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303091	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303091&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363879	381751826							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580460	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cc(C)nn1C |r|	InChI=1S/C28H32F3N5O/c1-17-12-21(16-27(3,4)15-17)36-24-11-6-19(25-13-18(2)34-35(25)5)14-23(24)33-26(36)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13-14,17,21H,12,15-16H2,1-5H3,(H,32,33)	JDEHFVUWCKSVCS-UHFFFAOYSA-N	303091	US10137110, Example 2-12::BDBM303092	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4300							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303091	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303091&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363879	381751826							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580461	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cc(C)nn1C |r|	InChI=1S/C28H32F3N5O/c1-17-12-21(16-27(3,4)15-17)36-24-11-6-19(25-13-18(2)34-35(25)5)14-23(24)33-26(36)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13-14,17,21H,12,15-16H2,1-5H3,(H,32,33)	JDEHFVUWCKSVCS-UHFFFAOYSA-N	303093	US10137110, Example 2-12-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1600							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303093	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303093&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363841	381751828							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580462	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cnn(C)c1 |r|	InChI=1S/C27H30F3N5O/c1-17-11-21(14-26(2,3)13-17)35-24-10-5-18(19-15-31-34(4)16-19)12-23(24)33-25(35)32-20-6-8-22(9-7-20)36-27(28,29)30/h5-10,12,15-17,21H,11,13-14H2,1-4H3,(H,32,33)	NHMZTMIYAWUYII-UHFFFAOYSA-N	303094	US10137110, Example 2-13::BDBM303095	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1100							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303094	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303094&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132087233	381751829							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580463	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cnn(C)c1 |r|	InChI=1S/C27H30F3N5O/c1-17-11-21(14-26(2,3)13-17)35-24-10-5-18(19-15-31-34(4)16-19)12-23(24)33-25(35)32-20-6-8-22(9-7-20)36-27(28,29)30/h5-10,12,15-17,21H,11,13-14H2,1-4H3,(H,32,33)	NHMZTMIYAWUYII-UHFFFAOYSA-N	303094	US10137110, Example 2-13::BDBM303095	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 240							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303094	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303094&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132087233	381751829							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580464	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cnn(C)c1 |r|	InChI=1S/C27H30F3N5O/c1-17-11-21(14-26(2,3)13-17)35-24-10-5-18(19-15-31-34(4)16-19)12-23(24)33-25(35)32-20-6-8-22(9-7-20)36-27(28,29)30/h5-10,12,15-17,21H,11,13-14H2,1-4H3,(H,32,33)	NHMZTMIYAWUYII-UHFFFAOYSA-N	303096	US10137110, Example 2-13-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1000							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303096	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303096&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363885	381751831							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580465	COc1cc(ccn1)-c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1 |r|	InChI=1S/C29H31F3N4O2/c1-18-13-22(17-28(2,3)16-18)36-25-10-5-19(20-11-12-33-26(15-20)37-4)14-24(25)35-27(36)34-21-6-8-23(9-7-21)38-29(30,31)32/h5-12,14-15,18,22H,13,16-17H2,1-4H3,(H,34,35)	AKHSZAXUATVIPD-UHFFFAOYSA-N	303097	US10137110, Example 2-14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1300							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303097	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303097&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363847	381751832							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580466	COC(=O)c1cccc(c1)-c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1 |r|	InChI=1S/C31H32F3N3O3/c1-19-14-24(18-30(2,3)17-19)37-27-13-8-21(20-6-5-7-22(15-20)28(38)39-4)16-26(27)36-29(37)35-23-9-11-25(12-10-23)40-31(32,33)34/h5-13,15-16,19,24H,14,17-18H2,1-4H3,(H,35,36)	UXWWBCPYGXQMPE-UHFFFAOYSA-N	303098	US10137110, Example 2-15	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1500							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303098	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303098&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132087206	381751833							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580467	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cn(C)nc1C(F)(F)F |r|	InChI=1S/C28H29F6N5O/c1-16-11-19(14-26(2,3)13-16)39-23-10-5-17(21-15-38(4)37-24(21)27(29,30)31)12-22(23)36-25(39)35-18-6-8-20(9-7-18)40-28(32,33)34/h5-10,12,15-16,19H,11,13-14H2,1-4H3,(H,35,36)	QYZPGSUVRWHSCH-UHFFFAOYSA-N	303099	BDBM303100::US10137110, Example 2-16	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 290							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303099	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303099&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363905	381751834							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580468	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cn(C)nc1C(F)(F)F |r|	InChI=1S/C28H29F6N5O/c1-16-11-19(14-26(2,3)13-16)39-23-10-5-17(21-15-38(4)37-24(21)27(29,30)31)12-22(23)36-25(39)35-18-6-8-20(9-7-18)40-28(32,33)34/h5-10,12,15-16,19H,11,13-14H2,1-4H3,(H,35,36)	QYZPGSUVRWHSCH-UHFFFAOYSA-N	303099	BDBM303100::US10137110, Example 2-16	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7800							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303099	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303099&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363905	381751834							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580469	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cn(C)nc1C(F)(F)F |r|	InChI=1S/C28H29F6N5O/c1-16-11-19(14-26(2,3)13-16)39-23-10-5-17(21-15-38(4)37-24(21)27(29,30)31)12-22(23)36-25(39)35-18-6-8-20(9-7-18)40-28(32,33)34/h5-10,12,15-16,19H,11,13-14H2,1-4H3,(H,35,36)	QYZPGSUVRWHSCH-UHFFFAOYSA-N	303101	US10137110, Example 2-16-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 780							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303101	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303101&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132087278	381751836							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580470	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1ccc(cc1)C(N)=O |r|	InChI=1S/C30H31F3N4O2/c1-18-14-23(17-29(2,3)16-18)37-26-13-8-21(19-4-6-20(7-5-19)27(34)38)15-25(26)36-28(37)35-22-9-11-24(12-10-22)39-30(31,32)33/h4-13,15,18,23H,14,16-17H2,1-3H3,(H2,34,38)(H,35,36)	XOGHXSDBLVHOCP-UHFFFAOYSA-N	303102	US10137110, Example 2-17	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 440							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303102	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303102&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363911	381751837							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580471	COC(=O)c1ccc(cc1)-c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1 |r|	InChI=1S/C31H32F3N3O3/c1-19-15-24(18-30(2,3)17-19)37-27-14-9-22(20-5-7-21(8-6-20)28(38)39-4)16-26(27)36-29(37)35-23-10-12-25(13-11-23)40-31(32,33)34/h5-14,16,19,24H,15,17-18H2,1-4H3,(H,35,36)	QAHNNXTUBRHHET-UHFFFAOYSA-N	303103	US10137110, Example 2-18	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4000							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303103	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303103&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132087297	381751838							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580472	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)nn(C)c1C |r|	InChI=1S/C29H34F3N5O/c1-17-13-22(16-28(4,5)15-17)37-25-12-7-20(26-18(2)35-36(6)19(26)3)14-24(25)34-27(37)33-21-8-10-23(11-9-21)38-29(30,31)32/h7-12,14,17,22H,13,15-16H2,1-6H3,(H,33,34)	QNRCBYNYEDWOFU-UHFFFAOYSA-N	303104	US10137110, Example 2-19	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1900							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303104	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303104&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363866	381751839							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580473	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1ccnn1C |r|	InChI=1S/C27H30F3N5O/c1-17-13-20(16-26(2,3)15-17)35-24-10-5-18(23-11-12-31-34(23)4)14-22(24)33-25(35)32-19-6-8-21(9-7-19)36-27(28,29)30/h5-12,14,17,20H,13,15-16H2,1-4H3,(H,32,33)	SGISYSOKQFHIRQ-UHFFFAOYSA-N	303105	US10137110, Example 2-20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303105	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303105&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363891	381751840							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580474	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(SC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)noc1C |r|	InChI=1S/C28H31F3N4OS/c1-16-12-21(15-27(4,5)14-16)35-24-11-6-19(25-17(2)34-36-18(25)3)13-23(24)33-26(35)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)	VCESBRKLVRUEPU-UHFFFAOYSA-N	303106	BDBM303107::US10137110, Example 2-21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303106	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303106&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363842	381751841							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580475	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(SC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)noc1C |r|	InChI=1S/C28H31F3N4OS/c1-16-12-21(15-27(4,5)14-16)35-24-11-6-19(25-17(2)34-36-18(25)3)13-23(24)33-26(35)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)	VCESBRKLVRUEPU-UHFFFAOYSA-N	303106	BDBM303107::US10137110, Example 2-21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1100							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303106	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303106&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363842	381751841							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580476	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(SC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)noc1C |r|	InChI=1S/C28H31F3N4OS/c1-16-12-21(15-27(4,5)14-16)35-24-11-6-19(25-17(2)34-36-18(25)3)13-23(24)33-26(35)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)	VCESBRKLVRUEPU-UHFFFAOYSA-N	303108	US10137110, Example 2-21-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 290							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303108	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303108&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363868	381751843							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580477	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(SC(F)(F)F)cc2)nc2cc(ccc12)-c1ccn[nH]1 |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN$|	InChI=1S/C26H28F3N5S/c1-16-12-19(15-25(2,3)14-16)34-23-9-4-17(21-10-11-30-33-21)13-22(23)32-24(34)31-18-5-7-20(8-6-18)35-26(27,28)29/h4-11,13,16,19H,12,14-15H2,1-3H3,(H,30,33)(H,31,32)	FXWHSKPNXCANCQ-UHFFFAOYSA-N	303109	US10137110, Example 2-22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 770							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303109	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303109&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132087304	381751844							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580478	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(ccc12)-c1c(C)noc1C |r|	InChI=1S/C28H31F3N4O/c1-16-12-22(15-27(4,5)14-16)35-24-11-6-19(25-17(2)34-36-18(25)3)13-23(24)33-26(35)32-21-9-7-20(8-10-21)28(29,30)31/h6-11,13,16,22H,12,14-15H2,1-5H3,(H,32,33)	YZTSWPDJOHSPBB-UHFFFAOYSA-N	303110	US10137110, Example 2-23::BDBM303111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303110	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303110&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363900	381751845							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580479	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(ccc12)-c1c(C)noc1C |r|	InChI=1S/C28H31F3N4O/c1-16-12-22(15-27(4,5)14-16)35-24-11-6-19(25-17(2)34-36-18(25)3)13-23(24)33-26(35)32-21-9-7-20(8-10-21)28(29,30)31/h6-11,13,16,22H,12,14-15H2,1-5H3,(H,32,33)	YZTSWPDJOHSPBB-UHFFFAOYSA-N	303110	US10137110, Example 2-23::BDBM303111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303110	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303110&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363900	381751845							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580480	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(ccc12)-c1c(C)noc1C |r|	InChI=1S/C28H31F3N4O/c1-16-12-22(15-27(4,5)14-16)35-24-11-6-19(25-17(2)34-36-18(25)3)13-23(24)33-26(35)32-21-9-7-20(8-10-21)28(29,30)31/h6-11,13,16,22H,12,14-15H2,1-5H3,(H,32,33)	YZTSWPDJOHSPBB-UHFFFAOYSA-N	303112	US10137110, Example 2-23-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 180							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303112	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303112&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363906	381751847							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580481	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(ccc12)-c1c(C)n[nH]c1C |r|	InChI=1S/C28H32F3N5/c1-16-12-22(15-27(4,5)14-16)36-24-11-6-19(25-17(2)34-35-18(25)3)13-23(24)33-26(36)32-21-9-7-20(8-10-21)28(29,30)31/h6-11,13,16,22H,12,14-15H2,1-5H3,(H,32,33)(H,34,35)	RZJCIVYZADASRT-UHFFFAOYSA-N	303113	US10137110, Example 2-24::BDBM303114	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303113	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303113&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363915	381751848							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580482	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(ccc12)-c1c(C)n[nH]c1C |r|	InChI=1S/C28H32F3N5/c1-16-12-22(15-27(4,5)14-16)36-24-11-6-19(25-17(2)34-35-18(25)3)13-23(24)33-26(36)32-21-9-7-20(8-10-21)28(29,30)31/h6-11,13,16,22H,12,14-15H2,1-5H3,(H,32,33)(H,34,35)	RZJCIVYZADASRT-UHFFFAOYSA-N	303113	US10137110, Example 2-24::BDBM303114	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303113	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303113&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363915	381751848							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580483	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(ccc12)-c1c(C)n[nH]c1C |r|	InChI=1S/C28H32F3N5/c1-16-12-22(15-27(4,5)14-16)36-24-11-6-19(25-17(2)34-35-18(25)3)13-23(24)33-26(36)32-21-9-7-20(8-10-21)28(29,30)31/h6-11,13,16,22H,12,14-15H2,1-5H3,(H,32,33)(H,34,35)	RZJCIVYZADASRT-UHFFFAOYSA-N	303115	US10137110, Example 2-24-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 140							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303115	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303115&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132087299	381751850							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580484	Cc1nnc(o1)-c1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C27H30F3N5O2/c1-16-33-34-23(36-16)17-6-11-22-21(12-17)32-24(31-18-7-9-20(10-8-18)37-27(28,29)30)35(22)19-13-25(2,3)15-26(4,5)14-19/h6-12,19H,13-15H2,1-5H3,(H,31,32)	OMFPJFMRZILTIK-UHFFFAOYSA-N	303116	5-(5-Methyl-1,3,4-oxadiazol-2-yl)-1-(3,3,5,5-tetramethylcyclohexyl)-N-[4-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-amine::US10137110, Example 2-25	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 130							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303116	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303116&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363843	381751851							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580485	Cc1nc(no1)-c1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C27H30F3N5O2/c1-16-31-23(34-37-16)17-6-11-22-21(12-17)33-24(32-18-7-9-20(10-8-18)36-27(28,29)30)35(22)19-13-25(2,3)15-26(4,5)14-19/h6-12,19H,13-15H2,1-5H3,(H,32,33)	WNVLGBAEFPZIIF-UHFFFAOYSA-N	303117	5-(5-Methyl-1,2,4-oxadiazol-3-yl)-1-(3,3,5,5-tetramethylcyclohexyl)-N-[4-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-amine::US10137110, Example 2-26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 220							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303117	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303117&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363870	381751852							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580486	C[C@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1nnn[nH]1 |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN$|	InChI=1S/C24H26F3N7O/c1-14-10-17(13-23(2,3)12-14)34-20-9-4-15(21-30-32-33-31-21)11-19(20)29-22(34)28-16-5-7-18(8-6-16)35-24(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,28,29)(H,30,31,32,33)	FGRWSNMADNLLTB-UHFFFAOYSA-N	303118	(+/-) 5-(1H-tetrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]-1-[(trans)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-2-amine::US10137110, Example 2-27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1800							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303118	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303118&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132087210	381751853							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580487	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1nnn[nH]1 |$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN$|	InChI=1S/C25H28F3N7O/c1-23(2)12-17(13-24(3,4)14-23)35-20-10-5-15(21-31-33-34-32-21)11-19(20)30-22(35)29-16-6-8-18(9-7-16)36-25(26,27)28/h5-11,17H,12-14H2,1-4H3,(H,29,30)(H,31,32,33,34)	ZVAWHXCMSDBDOJ-UHFFFAOYSA-N	303119	1-(3,3,5,5-tetramethylcyclohexyl)-5-(1H-tetrazol-5-yl)-N-[4-(trifluoromethoxy)-phenyl]-1H-benzimidazol-2-amine::US10137110, Example 2-28	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 70.0							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303119	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303119&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363871	381751854							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580488	Cc1n[nH]c(C)c1-c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2cc1C |(-4.49,3.72,;-5.82,2.95,;-7.29,3.42,;-8.19,2.18,;-7.29,.93,;-8.06,-.4,;-5.82,1.41,;-4.49,.64,;-3.16,1.41,;-1.82,.64,;-.36,1.11,;.55,-.13,;2.09,-.13,;2.86,1.2,;4.4,1.2,;5.17,2.53,;4.4,3.87,;5.17,5.2,;6.71,5.2,;7.48,6.53,;7.48,3.87,;8.19,4.8,;2.86,3.87,;2.09,2.53,;-.36,-1.38,;.04,-2.87,;1.53,-3.27,;1.93,-4.75,;3.41,-5.15,;3.26,-3.98,;.84,-5.84,;-.65,-5.44,;-2.19,-5.44,;-1.74,-6.53,;-1.05,-3.96,;-1.82,-.9,;-3.16,-1.67,;-4.49,-.9,;-5.82,-1.67,)|	InChI=1S/C30H36F3N5O/c1-17-12-25-24(13-23(17)26-18(2)36-37-19(26)3)35-27(34-20-8-10-22(11-9-20)39-30(31,32)33)38(25)21-14-28(4,5)16-29(6,7)15-21/h8-13,21H,14-16H2,1-7H3,(H,34,35)(H,36,37)	GMYBUXILLTVZDP-UHFFFAOYSA-N	303120	5-(3,5-dimethyl-1H-pyrazol-4-yl)-6-methyl-1-(3,3,5,5-tetramethylcyclohexyl)-N-[4-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-amine::US10137110, Example 2-29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4000							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303120	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303120&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554287	381751855							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580489	Cc1nnc([nH]1)-c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2cc1C	InChI=1S/C28H33F3N6O/c1-16-11-23-22(12-21(16)24-32-17(2)35-36-24)34-25(33-18-7-9-20(10-8-18)38-28(29,30)31)37(23)19-13-26(3,4)15-27(5,6)14-19/h7-12,19H,13-15H2,1-6H3,(H,33,34)(H,32,35,36)	VKXKTXAQLBTYSO-UHFFFAOYSA-N	303121	6-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)-1-(3,3,5,5-tetramethylcyclohexyl)-N-[4-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-amine::US10137110, Example 2-30	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 120							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303121	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303121&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363874	381751856							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580490	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1nnc(C)o1 |r|	InChI=1S/C26H28F3N5O2/c1-15-11-19(14-25(3,4)13-15)34-22-10-5-17(23-33-32-16(2)35-23)12-21(22)31-24(34)30-18-6-8-20(9-7-18)36-26(27,28)29/h5-10,12,15,19H,11,13-14H2,1-4H3,(H,30,31)	WJELXOOQYUBURM-UHFFFAOYSA-N	303122	(+/-) 5-(5-methyl-1,3,4-oxadiazol-2-yl)-N-[4-(trifluoromethoxy)phenyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-2-amine::US10137110, Example 2-31	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 390							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303122	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303122&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363845	381751857							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580491	COc1c(F)cc(cc1F)-c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1 |r|	InChI=1S/C30H30F5N3O2/c1-17-11-21(16-29(2,3)15-17)38-26-10-5-18(19-12-23(31)27(39-4)24(32)13-19)14-25(26)37-28(38)36-20-6-8-22(9-7-20)40-30(33,34)35/h5-10,12-14,17,21H,11,15-16H2,1-4H3,(H,36,37)	QTGOZBGNWLFRFM-UHFFFAOYSA-N	303123	(+/-) 5-(3,5-difluoro-4-methoxyphenyl)-N-[4-(trifluoromethoxy)phenyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-2-amine::US10137110, Example 2-32	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303123	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303123&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363894	381751858							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580492	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cc(F)c(O)c(F)c1 |r|	InChI=1S/C29H28F5N3O2/c1-16-10-20(15-28(2,3)14-16)37-25-9-4-17(18-11-22(30)26(38)23(31)12-18)13-24(25)36-27(37)35-19-5-7-21(8-6-19)39-29(32,33)34/h4-9,11-13,16,20,38H,10,14-15H2,1-3H3,(H,35,36)	SHXODSZFUOGYBM-UHFFFAOYSA-N	303124	(+/-) 2,6-difluoro-4-(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)phenol::US10137110, Example 2-33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 670							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303124	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303124&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363882	381751859							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580493	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cc(C)c(O)c(C)c1 |r|	InChI=1S/C31H34F3N3O2/c1-18-12-24(17-30(4,5)16-18)37-27-11-6-21(22-13-19(2)28(38)20(3)14-22)15-26(27)36-29(37)35-23-7-9-25(10-8-23)39-31(32,33)34/h6-11,13-15,18,24,38H,12,16-17H2,1-5H3,(H,35,36)	PHJFIMMUQDBAEE-UHFFFAOYSA-N	303125	US10137110, Example 2-34	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 180							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303125	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303125&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363838	381751860							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580494	CCOc1noc(C)c1-c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1 |r|	InChI=1S/C29H33F3N4O3/c1-6-37-26-25(18(3)39-35-26)19-7-12-24-23(14-19)34-27(36(24)21-13-17(2)15-28(4,5)16-21)33-20-8-10-22(11-9-20)38-29(30,31)32/h7-12,14,17,21H,6,13,15-16H2,1-5H3,(H,33,34)	LEMLYPLCWHQZGX-UHFFFAOYSA-N	303126	(+/-) 5-(3-ethoxy-5-methyl-1,2-oxazol-4-yl)-N-[4-(trifluoromethoxy)phenyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-2-amine::US10137110, Example 2-35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 240							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303126	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303126&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132087277	381751861							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580495	Cc1cc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C1OC(=O)NC1=O	InChI=1S/C28H31F3N4O4/c1-15-10-21-20(11-19(15)22-23(36)34-25(37)38-22)33-24(32-16-6-8-18(9-7-16)39-28(29,30)31)35(21)17-12-26(2,3)14-27(4,5)13-17/h6-11,17,22H,12-14H2,1-5H3,(H,32,33)(H,34,36,37)	GJHZRRYSYJHQQN-UHFFFAOYSA-N	303127	5-[6-methyl-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazol-5-yl]-1,3-oxazolidine-2,4-dione::US10137110, Example 2-36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 14.0							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303127	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303127&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363887	381751862							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580496	Cc1cc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1-c1cc(O)no1	InChI=1S/C28H31F3N4O3/c1-16-10-22-21(11-20(16)23-12-24(36)34-38-23)33-25(32-17-6-8-19(9-7-17)37-28(29,30)31)35(22)18-13-26(2,3)15-27(4,5)14-18/h6-12,18H,13-15H2,1-5H3,(H,32,33)(H,34,36)	QRNMTNCXNVMNDI-UHFFFAOYSA-N	303128	5-[6-methyl-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazol-5-yl]-1,2-oxazol-3-ol::US10137110, Example 2-37	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 30.0							US Patent		10.7270/Q2J968F3		aid1796134	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303128	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303128&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363865	381751863							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580497	C[C@@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)noc1C |r|	InChI=1S/C28H31F3N4O2/c1-16-12-21(15-27(4,5)14-16)35-24-11-6-19(25-17(2)34-37-18(25)3)13-23(24)33-26(35)32-20-7-9-22(10-8-20)36-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)	NDUCHRAKQIXMCH-UHFFFAOYSA-N	303075	(+/1)5-(3,5-dimethyl-1,2-oxazol-4-yl)-N-[4-(trifluoromethoxy)phenyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-2-amine::US10137110, Example 2-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 900							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303075	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303075&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554279	381751810							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580498	C[C@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cccc(c1)C(O)=O |r|	InChI=1S/C30H30F3N3O3/c1-18-13-23(17-29(2,3)16-18)36-26-12-7-20(19-5-4-6-21(14-19)27(37)38)15-25(26)35-28(36)34-22-8-10-24(11-9-22)39-30(31,32)33/h4-12,14-15,18,23H,13,16-17H2,1-3H3,(H,34,35)(H,37,38)	DCLIXYJDCCEKAF-UHFFFAOYSA-N	303078	US10137110, Example 2-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 360							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303078	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303078&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554280	381751813							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580499	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cn[nH]c1 |r|	InChI=1S/C26H28F3N5O/c1-16-10-20(13-25(2,3)12-16)34-23-9-4-17(18-14-30-31-15-18)11-22(23)33-24(34)32-19-5-7-21(8-6-19)35-26(27,28)29/h4-9,11,14-16,20H,10,12-13H2,1-3H3,(H,30,31)(H,32,33)	IFOCIVINXZHLNV-UHFFFAOYSA-N	303080	US10137110, Example 2-4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 600							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303080	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303080&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554281	381751815							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580500	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)n[nH]c1C |r|	InChI=1S/C28H32F3N5O/c1-16-12-21(15-27(4,5)14-16)36-24-11-6-19(25-17(2)34-35-18(25)3)13-23(24)33-26(36)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)(H,34,35)	YINXLLNIRQGDOR-UHFFFAOYSA-N	303081	US10137110, Example 2-5::BDBM303082	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4000							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303081	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303081&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554282	381751816							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580501	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)n[nH]c1C |r|	InChI=1S/C28H32F3N5O/c1-16-12-21(15-27(4,5)14-16)36-24-11-6-19(25-17(2)34-35-18(25)3)13-23(24)33-26(36)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)(H,34,35)	YINXLLNIRQGDOR-UHFFFAOYSA-N	303083	US10137110, Example 2-5-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1500							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303083	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303083&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554283	381751818							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580502	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1c[nH]nc1C |r|	InChI=1S/C27H30F3N5O/c1-16-11-20(14-26(3,4)13-16)35-24-10-5-18(22-15-31-34-17(22)2)12-23(24)33-25(35)32-19-6-8-21(9-7-19)36-27(28,29)30/h5-10,12,15-16,20H,11,13-14H2,1-4H3,(H,31,34)(H,32,33)	KUFZBAQLEZABNJ-UHFFFAOYSA-N	303084	US10137110, Example 2-7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1200							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303084	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303084&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554284	381751819							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580503	C[C@H]5C[C@@H](n4c(Nc1ccc(OC(F)(F)F)cc1)nc3cc(c2ccn[nH]2)ccc34)CC(C)(C)C5	InChI=1S/C26H28F3N5O/c1-16-12-19(15-25(2,3)14-16)34-23-9-4-17(21-10-11-30-33-21)13-22(23)32-24(34)31-18-5-7-20(8-6-18)35-26(27,28)29/h4-11,13,16,19H,12,14-15H2,1-3H3,(H,30,33)(H,31,32)	PEEVXZMPBDEIMD-UHFFFAOYSA-N	303085	US10137110, Example 2-8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2000							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303085	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303085&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363892	381751820							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580504	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cnoc1 |r|	InChI=1S/C26H27F3N4O2/c1-16-10-20(13-25(2,3)12-16)33-23-9-4-17(18-14-30-34-15-18)11-22(23)32-24(33)31-19-5-7-21(8-6-19)35-26(27,28)29/h4-9,11,14-16,20H,10,12-13H2,1-3H3,(H,31,32)	JPUDOTIZBUNJRJ-UHFFFAOYSA-N	303086	US10137110, Example 2-9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2000							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303086	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303086&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132087292	381751821							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580505	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(SC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)n[nH]c1C |r|	InChI=1S/C28H32F3N5S/c1-16-12-21(15-27(4,5)14-16)36-24-11-6-19(25-17(2)34-35-18(25)3)13-23(24)33-26(36)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)(H,34,35)	DFBMMLUAYOCUSW-UHFFFAOYSA-N	303087	US10137110, Example 2-10::BDBM303088	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2000							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303087	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303087&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554285	381751822							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580506	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(SC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)n[nH]c1C |r|	InChI=1S/C28H32F3N5S/c1-16-12-21(15-27(4,5)14-16)36-24-11-6-19(25-17(2)34-35-18(25)3)13-23(24)33-26(36)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)(H,34,35)	DFBMMLUAYOCUSW-UHFFFAOYSA-N	303087	US10137110, Example 2-10::BDBM303088	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303087	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303087&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554285	381751822							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580507	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(SC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)n[nH]c1C |r|	InChI=1S/C28H32F3N5S/c1-16-12-21(15-27(4,5)14-16)36-24-11-6-19(25-17(2)34-35-18(25)3)13-23(24)33-26(36)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)(H,34,35)	DFBMMLUAYOCUSW-UHFFFAOYSA-N	303089	US10137110, Example 2-10-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3000							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303089	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303089&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554286	381751824							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580508	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cccc(c1)C(N)=O |r|	InChI=1S/C30H31F3N4O2/c1-18-13-23(17-29(2,3)16-18)37-26-12-7-20(19-5-4-6-21(14-19)27(34)38)15-25(26)36-28(37)35-22-8-10-24(11-9-22)39-30(31,32)33/h4-12,14-15,18,23H,13,16-17H2,1-3H3,(H2,34,38)(H,35,36)	DLQKRKOXZUBFMG-UHFFFAOYSA-N	303090	US10137110, Example 2-11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2800							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303090	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303090&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363913	381751825							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580509	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cc(C)nn1C |r|	InChI=1S/C28H32F3N5O/c1-17-12-21(16-27(3,4)15-17)36-24-11-6-19(25-13-18(2)34-35(25)5)14-23(24)33-26(36)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13-14,17,21H,12,15-16H2,1-5H3,(H,32,33)	JDEHFVUWCKSVCS-UHFFFAOYSA-N	303091	US10137110, Example 2-12::BDBM303092	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 8000							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303091	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303091&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363879	381751826							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580510	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1cnn(C)c1 |r|	InChI=1S/C27H30F3N5O/c1-17-11-21(14-26(2,3)13-17)35-24-10-5-18(19-15-31-34(4)16-19)12-23(24)33-25(35)32-20-6-8-22(9-7-20)36-27(28,29)30/h5-10,12,15-17,21H,11,13-14H2,1-4H3,(H,32,33)	NHMZTMIYAWUYII-UHFFFAOYSA-N	303094	US10137110, Example 2-13::BDBM303095	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5000							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303094	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303094&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132087233	381751829							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580511	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)nn(C)c1C |r|	InChI=1S/C29H34F3N5O/c1-17-13-22(16-28(4,5)15-17)37-25-12-7-20(26-18(2)35-36(6)19(26)3)14-24(25)34-27(37)33-21-8-10-23(11-9-21)38-29(30,31)32/h7-12,14,17,22H,13,15-16H2,1-6H3,(H,33,34)	QNRCBYNYEDWOFU-UHFFFAOYSA-N	303104	US10137110, Example 2-19	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303104	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303104&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363866	381751839							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580512	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1ccnn1C |r|	InChI=1S/C27H30F3N5O/c1-17-13-20(16-26(2,3)15-17)35-24-10-5-18(23-11-12-31-34(23)4)14-22(24)33-25(35)32-19-6-8-21(9-7-19)36-27(28,29)30/h5-12,14,17,20H,13,15-16H2,1-4H3,(H,32,33)	SGISYSOKQFHIRQ-UHFFFAOYSA-N	303105	US10137110, Example 2-20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4000							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303105	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303105&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363891	381751840							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580513	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(SC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)noc1C |r|	InChI=1S/C28H31F3N4OS/c1-16-12-21(15-27(4,5)14-16)35-24-11-6-19(25-17(2)34-36-18(25)3)13-23(24)33-26(35)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)	VCESBRKLVRUEPU-UHFFFAOYSA-N	303106	BDBM303107::US10137110, Example 2-21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303106	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303106&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363842	381751841							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580514	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(SC(F)(F)F)cc2)nc2cc(ccc12)-c1c(C)noc1C |r|	InChI=1S/C28H31F3N4OS/c1-16-12-21(15-27(4,5)14-16)35-24-11-6-19(25-17(2)34-36-18(25)3)13-23(24)33-26(35)32-20-7-9-22(10-8-20)37-28(29,30)31/h6-11,13,16,21H,12,14-15H2,1-5H3,(H,32,33)	VCESBRKLVRUEPU-UHFFFAOYSA-N	303108	US10137110, Example 2-21-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2500							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303108	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303108&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363868	381751843							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580515	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(SC(F)(F)F)cc2)nc2cc(ccc12)-c1ccn[nH]1 |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN$|	InChI=1S/C26H28F3N5S/c1-16-12-19(15-25(2,3)14-16)34-23-9-4-17(21-10-11-30-33-21)13-22(23)32-24(34)31-18-5-7-20(8-6-18)35-26(27,28)29/h4-11,13,16,19H,12,14-15H2,1-3H3,(H,30,33)(H,31,32)	FXWHSKPNXCANCQ-UHFFFAOYSA-N	303109	US10137110, Example 2-22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2500							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303109	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303109&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132087304	381751844							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580516	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(ccc12)-c1c(C)noc1C |r|	InChI=1S/C28H31F3N4O/c1-16-12-22(15-27(4,5)14-16)35-24-11-6-19(25-17(2)34-36-18(25)3)13-23(24)33-26(35)32-21-9-7-20(8-10-21)28(29,30)31/h6-11,13,16,22H,12,14-15H2,1-5H3,(H,32,33)	YZTSWPDJOHSPBB-UHFFFAOYSA-N	303112	US10137110, Example 2-23-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303112	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303112&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363906	381751847							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580517	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(ccc12)-c1c(C)n[nH]c1C |r|	InChI=1S/C28H32F3N5/c1-16-12-22(15-27(4,5)14-16)36-24-11-6-19(25-17(2)34-35-18(25)3)13-23(24)33-26(36)32-21-9-7-20(8-10-21)28(29,30)31/h6-11,13,16,22H,12,14-15H2,1-5H3,(H,32,33)(H,34,35)	RZJCIVYZADASRT-UHFFFAOYSA-N	303115	US10137110, Example 2-24-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7000							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303115	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303115&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132087299	381751850							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580518	Cc1nc(no1)-c1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C27H30F3N5O2/c1-16-31-23(34-37-16)17-6-11-22-21(12-17)33-24(32-18-7-9-20(10-8-18)36-27(28,29)30)35(22)19-13-25(2,3)15-26(4,5)14-19/h6-12,19H,13-15H2,1-5H3,(H,32,33)	WNVLGBAEFPZIIF-UHFFFAOYSA-N	303117	5-(5-Methyl-1,2,4-oxadiazol-3-yl)-1-(3,3,5,5-tetramethylcyclohexyl)-N-[4-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-amine::US10137110, Example 2-26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303117	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303117&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363870	381751852							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580519	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)-c1nnn[nH]1 |$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN$|	InChI=1S/C25H28F3N7O/c1-23(2)12-17(13-24(3,4)14-23)35-20-10-5-15(21-31-33-34-32-21)11-19(20)30-22(35)29-16-6-8-18(9-7-16)36-25(26,27)28/h5-11,17H,12-14H2,1-4H3,(H,29,30)(H,31,32,33,34)	ZVAWHXCMSDBDOJ-UHFFFAOYSA-N	303119	1-(3,3,5,5-tetramethylcyclohexyl)-5-(1H-tetrazol-5-yl)-N-[4-(trifluoromethoxy)-phenyl]-1H-benzimidazol-2-amine::US10137110, Example 2-28	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 200							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303119	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303119&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363871	381751854							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580520	Cc1n[nH]c(C)c1-c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2cc1C |(-4.49,3.72,;-5.82,2.95,;-7.29,3.42,;-8.19,2.18,;-7.29,.93,;-8.06,-.4,;-5.82,1.41,;-4.49,.64,;-3.16,1.41,;-1.82,.64,;-.36,1.11,;.55,-.13,;2.09,-.13,;2.86,1.2,;4.4,1.2,;5.17,2.53,;4.4,3.87,;5.17,5.2,;6.71,5.2,;7.48,6.53,;7.48,3.87,;8.19,4.8,;2.86,3.87,;2.09,2.53,;-.36,-1.38,;.04,-2.87,;1.53,-3.27,;1.93,-4.75,;3.41,-5.15,;3.26,-3.98,;.84,-5.84,;-.65,-5.44,;-2.19,-5.44,;-1.74,-6.53,;-1.05,-3.96,;-1.82,-.9,;-3.16,-1.67,;-4.49,-.9,;-5.82,-1.67,)|	InChI=1S/C30H36F3N5O/c1-17-12-25-24(13-23(17)26-18(2)36-37-19(26)3)35-27(34-20-8-10-22(11-9-20)39-30(31,32)33)38(25)21-14-28(4,5)16-29(6,7)15-21/h8-13,21H,14-16H2,1-7H3,(H,34,35)(H,36,37)	GMYBUXILLTVZDP-UHFFFAOYSA-N	303120	5-(3,5-dimethyl-1H-pyrazol-4-yl)-6-methyl-1-(3,3,5,5-tetramethylcyclohexyl)-N-[4-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-amine::US10137110, Example 2-29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2700							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303120	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303120&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137554287	381751855							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580521	Cc1nnc([nH]1)-c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2cc1C	InChI=1S/C28H33F3N6O/c1-16-11-23-22(12-21(16)24-32-17(2)35-36-24)34-25(33-18-7-9-20(10-8-18)38-28(29,30)31)37(23)19-13-26(3,4)15-27(5,6)14-19/h7-12,19H,13-15H2,1-6H3,(H,33,34)(H,32,35,36)	VKXKTXAQLBTYSO-UHFFFAOYSA-N	303121	6-methyl-5-(5-methyl-4H-1,2,4-triazol-3-yl)-1-(3,3,5,5-tetramethylcyclohexyl)-N-[4-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-amine::US10137110, Example 2-30	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1500							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303121	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303121&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363874	381751856							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580522	Cc1cc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C1OC(=O)NC1=O	InChI=1S/C28H31F3N4O4/c1-15-10-21-20(11-19(15)22-23(36)34-25(37)38-22)33-24(32-16-6-8-18(9-7-16)39-28(29,30)31)35(21)17-12-26(2,3)14-27(4,5)13-17/h6-11,17,22H,12-14H2,1-5H3,(H,32,33)(H,34,36,37)	GJHZRRYSYJHQQN-UHFFFAOYSA-N	303127	5-[6-methyl-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazol-5-yl]-1,3-oxazolidine-2,4-dione::US10137110, Example 2-36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 22.0							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303127	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303127&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363887	381751862							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
580523	Cc1cc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1-c1cc(O)no1	InChI=1S/C28H31F3N4O3/c1-16-10-22-21(11-20(16)23-12-24(36)34-38-23)33-25(32-17-6-8-19(9-7-17)37-28(29,30)31)35(22)18-13-26(2,3)15-27(4,5)14-18/h6-12,18H,13-15H2,1-5H3,(H,32,33)(H,34,36)	QRNMTNCXNVMNDI-UHFFFAOYSA-N	303128	5-[6-methyl-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazol-5-yl]-1,2-oxazol-3-ol::US10137110, Example 2-37	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 250							US Patent		10.7270/Q2J968F3		aid1796135	US10137110	Rehwinkel, H; Anlauf, S; Nguyen, D; Panknin, O; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM; Toschi, G	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303128	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303128&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363865	381751863							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582250	COC(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C25H28F3N3O3/c1-15-11-18(14-24(2,3)13-15)31-21-12-16(22(32)33-4)5-10-20(21)30-23(31)29-17-6-8-19(9-7-17)34-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,29,30)	HQLJGKDTIHKATM-UHFFFAOYSA-N	303449	(+-) methyl 2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-6-carboxylate::US10138226, Example 2-1::BDBM303450	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 140							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303449	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303449&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363770	381752183							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582251	COC(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C25H28F3N3O3/c1-15-11-18(14-24(2,3)13-15)31-21-12-16(22(32)33-4)5-10-20(21)30-23(31)29-17-6-8-19(9-7-17)34-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,29,30)	HQLJGKDTIHKATM-UHFFFAOYSA-N	303449	(+-) methyl 2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-6-carboxylate::US10138226, Example 2-1::BDBM303450	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 310							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303449	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303449&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363770	381752183							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582252	COC(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C25H28F3N3O3/c1-15-11-18(14-24(2,3)13-15)31-21-12-16(22(32)33-4)5-10-20(21)30-23(31)29-17-6-8-19(9-7-17)34-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,29,30)	HQLJGKDTIHKATM-UHFFFAOYSA-N	303451	methyl 2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-6-carboxylate, enantiomer B::US10138226, Example 2-1-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 50.0							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303451	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303451&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363765	381752185							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582253	COC(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C25H28F3N3O3/c1-15-11-18(14-24(2,3)13-15)31-21-12-16(22(32)33-4)5-10-20(21)30-23(31)29-17-6-8-19(9-7-17)34-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,29,30)	HQLJGKDTIHKATM-UHFFFAOYSA-N	303453	(+-) methyl 2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(trans)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-6-carboxylate::US10138226, Example 2-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 540							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303453	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303453&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363774	381752187							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582254	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(O)=O |r|	InChI=1S/C24H26F3N3O3/c1-14-10-17(13-23(2,3)12-14)30-20-11-15(21(31)32)4-9-19(20)29-22(30)28-16-5-7-18(8-6-16)33-24(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,28,29)(H,31,32)	VLZXUTRARUWCKN-UHFFFAOYSA-N	303454	(+-) 2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-6-carboxylic acid::US10138226, Example 2-3::BDBM303455	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2100							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303454	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303454&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363817	381752188							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582255	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(O)=O |r|	InChI=1S/C24H26F3N3O3/c1-14-10-17(13-23(2,3)12-14)30-20-11-15(21(31)32)4-9-19(20)29-22(30)28-16-5-7-18(8-6-16)33-24(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,28,29)(H,31,32)	VLZXUTRARUWCKN-UHFFFAOYSA-N	303454	(+-) 2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-6-carboxylic acid::US10138226, Example 2-3::BDBM303455	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7800							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303454	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303454&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363817	381752188							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582256	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(O)=O |r|	InChI=1S/C24H26F3N3O3/c1-14-10-17(13-23(2,3)12-14)30-20-11-15(21(31)32)4-9-19(20)29-22(30)28-16-5-7-18(8-6-16)33-24(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,28,29)(H,31,32)	VLZXUTRARUWCKN-UHFFFAOYSA-N	303456	2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-6-carboxylic acid, enantiomer B::US10138226, Example 2-3-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3400							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303456	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303456&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363800	381752190							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582257	C[C@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(O)=O |r|	InChI=1S/C24H26F3N3O3/c1-14-10-17(13-23(2,3)12-14)30-20-11-15(21(31)32)4-9-19(20)29-22(30)28-16-5-7-18(8-6-16)33-24(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,28,29)(H,31,32)	VLZXUTRARUWCKN-UHFFFAOYSA-N	303457	(+-) 2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(trans)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-6-carboxylic acid::US10138226, Example 2-4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2600							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303457	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303457&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132084692	381752191							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582258	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)NC1CCCC1 |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;$|	InChI=1S/C29H35F3N4O2/c1-18-14-22(17-28(2,3)16-18)36-25-15-19(26(37)33-20-6-4-5-7-20)8-13-24(25)35-27(36)34-21-9-11-23(12-10-21)38-29(30,31)32/h8-13,15,18,20,22H,4-7,14,16-17H2,1-3H3,(H,33,37)(H,34,35)	RQFMCRCOGOSCQE-UHFFFAOYSA-N	303458	(+-) N-cyclopentyl-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-6-carboxamide::US10138226, Example 2-5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303458	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303458&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363805	381752192							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582259	CCN(C)C(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C27H33F3N4O2/c1-6-33(5)24(35)18-7-12-22-23(14-18)34(20-13-17(2)15-26(3,4)16-20)25(32-22)31-19-8-10-21(11-9-19)36-27(28,29)30/h7-12,14,17,20H,6,13,15-16H2,1-5H3,(H,31,32)	MCDUFUWYFBBHFI-UHFFFAOYSA-N	303459	US10138226, Example 2-6::BDBM303460::(+-) N-ethyl-N-methyl-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-6-carboxamide	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 240							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303459	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303459&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363780	381752193							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582260	CCN(C)C(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C27H33F3N4O2/c1-6-33(5)24(35)18-7-12-22-23(14-18)34(20-13-17(2)15-26(3,4)16-20)25(32-22)31-19-8-10-21(11-9-19)36-27(28,29)30/h7-12,14,17,20H,6,13,15-16H2,1-5H3,(H,31,32)	MCDUFUWYFBBHFI-UHFFFAOYSA-N	303459	US10138226, Example 2-6::BDBM303460::(+-) N-ethyl-N-methyl-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-6-carboxamide	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 150							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303459	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303459&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363780	381752193							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582261	CCN(C)C(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C27H33F3N4O2/c1-6-33(5)24(35)18-7-12-22-23(14-18)34(20-13-17(2)15-26(3,4)16-20)25(32-22)31-19-8-10-21(11-9-19)36-27(28,29)30/h7-12,14,17,20H,6,13,15-16H2,1-5H3,(H,31,32)	MCDUFUWYFBBHFI-UHFFFAOYSA-N	303461	N-ethyl-N-methyl-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-6-carboxamide, enantiomer B::US10138226, Example 2-6-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 400							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303461	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303461&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132084672	381752195							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582262	CCN(CC)C(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C28H35F3N4O2/c1-6-34(7-2)25(36)19-8-13-23-24(15-19)35(21-14-18(3)16-27(4,5)17-21)26(33-23)32-20-9-11-22(12-10-20)37-28(29,30)31/h8-13,15,18,21H,6-7,14,16-17H2,1-5H3,(H,32,33)	QBJARTJUSOVBRB-UHFFFAOYSA-N	303462	US10138226, Example 2-7::BDBM303464	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 370							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303462	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303462&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132084678	381752196							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582263	CCN(CC)C(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C28H35F3N4O2/c1-6-34(7-2)25(36)19-8-13-23-24(15-19)35(21-14-18(3)16-27(4,5)17-21)26(33-23)32-20-9-11-22(12-10-20)37-28(29,30)31/h8-13,15,18,21H,6-7,14,16-17H2,1-5H3,(H,32,33)	QBJARTJUSOVBRB-UHFFFAOYSA-N	303462	US10138226, Example 2-7::BDBM303464	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 240							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303462	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303462&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132084678	381752196							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582264	CCN(CC)C(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C28H35F3N4O2/c1-6-34(7-2)25(36)19-8-13-23-24(15-19)35(21-14-18(3)16-27(4,5)17-21)26(33-23)32-20-9-11-22(12-10-20)37-28(29,30)31/h8-13,15,18,21H,6-7,14,16-17H2,1-5H3,(H,32,33)	QBJARTJUSOVBRB-UHFFFAOYSA-N	303465	US10138226, Example 2-7-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 380							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303465	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303465&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132084691	381752199							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582265	CNC(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C25H29F3N4O2/c1-15-11-18(14-24(2,3)13-15)32-21-12-16(22(33)29-4)5-10-20(21)31-23(32)30-17-6-8-19(9-7-17)34-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,29,33)(H,30,31)	OSKWGXJRJLTGHW-UHFFFAOYSA-N	303466	BDBM303467::US10138226, Example 2-8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 430							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303466	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303466&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132084674	381752200							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582266	CNC(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C25H29F3N4O2/c1-15-11-18(14-24(2,3)13-15)32-21-12-16(22(33)29-4)5-10-20(21)31-23(32)30-17-6-8-19(9-7-17)34-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,29,33)(H,30,31)	OSKWGXJRJLTGHW-UHFFFAOYSA-N	303466	BDBM303467::US10138226, Example 2-8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 920							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303466	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303466&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132084674	381752200							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582267	CNC(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C25H29F3N4O2/c1-15-11-18(14-24(2,3)13-15)32-21-12-16(22(33)29-4)5-10-20(21)31-23(32)30-17-6-8-19(9-7-17)34-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,29,33)(H,30,31)	OSKWGXJRJLTGHW-UHFFFAOYSA-N	303468	US10138226, Example 2-8-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1200							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303468	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303468&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132084673	381752202							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582268	COC(=O)CN(C)C(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C28H33F3N4O4/c1-17-12-20(15-27(2,3)14-17)35-23-13-18(25(37)34(4)16-24(36)38-5)6-11-22(23)33-26(35)32-19-7-9-21(10-8-19)39-28(29,30)31/h6-11,13,17,20H,12,14-16H2,1-5H3,(H,32,33)	KSKYKUNWMGBGKU-UHFFFAOYSA-N	303469	US10138226, Example 2-9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 250							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303469	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303469&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363810	381752203							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582269	COC(=O)CN(C)C(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C28H33F3N4O4/c1-17-12-20(15-27(2,3)14-17)35-23-13-18(25(37)34(4)16-24(36)38-5)6-11-22(23)33-26(35)32-19-7-9-21(10-8-19)39-28(29,30)31/h6-11,13,17,20H,12,14-16H2,1-5H3,(H,32,33)	KSKYKUNWMGBGKU-UHFFFAOYSA-N	303470	US10138226, Example 2-10	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 6600							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303470&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363797	381752204							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582270	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)N(C)CC(O)=O |r|	InChI=1S/C27H31F3N4O4/c1-16-11-19(14-26(2,3)13-16)34-22-12-17(24(37)33(4)15-23(35)36)5-10-21(22)32-25(34)31-18-6-8-20(9-7-18)38-27(28,29)30/h5-10,12,16,19H,11,13-15H2,1-4H3,(H,31,32)(H,35,36)	KAPTXXVDJFEUBB-UHFFFAOYSA-N	303471	US10138226, Example 2-11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 7600							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303471	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303471&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132084693	381752205							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582271	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)NCC(O)=O |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;$|	InChI=1S/C26H29F3N4O4/c1-15-10-18(13-25(2,3)12-15)33-21-11-16(23(36)30-14-22(34)35)4-9-20(21)32-24(33)31-17-5-7-19(8-6-17)37-26(27,28)29/h4-9,11,15,18H,10,12-14H2,1-3H3,(H,30,36)(H,31,32)(H,34,35)	YXILDNVQRCVNEI-UHFFFAOYSA-N	303472	US10138226, Example 2-12	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303472	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303472&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132084700	381752206							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582272	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)NCCO |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;$|	InChI=1S/C26H31F3N4O3/c1-16-12-19(15-25(2,3)14-16)33-22-13-17(23(35)30-10-11-34)4-9-21(22)32-24(33)31-18-5-7-20(8-6-18)36-26(27,28)29/h4-9,13,16,19,34H,10-12,14-15H2,1-3H3,(H,30,35)(H,31,32)	ICDPFCCFSZAZRJ-UHFFFAOYSA-N	303473	US10138226, Example 2-13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2200							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303473&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363783	381752207					C04080		1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582273	COC(=O)CCNC(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2c1 |r,$;;;;;;HN;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;$|	InChI=1S/C28H33F3N4O4/c1-17-13-20(16-27(2,3)15-17)35-23-14-18(25(37)32-12-11-24(36)38-4)5-10-22(23)34-26(35)33-19-6-8-21(9-7-19)39-28(29,30)31/h5-10,14,17,20H,11-13,15-16H2,1-4H3,(H,32,37)(H,33,34)	UPZAYQSPLUASSQ-UHFFFAOYSA-N	303474	US10138226, Example 2-14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303474	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303474&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132084677	381752208							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582274	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)NCCC(O)=O |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;$|	InChI=1S/C27H31F3N4O4/c1-16-12-19(15-26(2,3)14-16)34-22-13-17(24(37)31-11-10-23(35)36)4-9-21(22)33-25(34)32-18-5-7-20(8-6-18)38-27(28,29)30/h4-9,13,16,19H,10-12,14-15H2,1-3H3,(H,31,37)(H,32,33)(H,35,36)	KPLBNWMDWBMXSP-UHFFFAOYSA-N	303475	US10138226, Example 2-15	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303475&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132084679	381752209							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582275	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)N1CCOCC1 |r|	InChI=1S/C28H33F3N4O3/c1-18-14-21(17-27(2,3)16-18)35-24-15-19(25(36)34-10-12-37-13-11-34)4-9-23(24)33-26(35)32-20-5-7-22(8-6-20)38-28(29,30)31/h4-9,15,18,21H,10-14,16-17H2,1-3H3,(H,32,33)	ULRNBKKORGHLGD-UHFFFAOYSA-N	303476	US10138226, Example 2-16-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 160							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303476	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303476&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363792	381752210							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582276	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)N1CCOCC1 |r|	InChI=1S/C28H33F3N4O3/c1-18-14-21(17-27(2,3)16-18)35-24-15-19(25(36)34-10-12-37-13-11-34)4-9-23(24)33-26(35)32-20-5-7-22(8-6-20)38-28(29,30)31/h4-9,15,18,21H,10-14,16-17H2,1-3H3,(H,32,33)	ULRNBKKORGHLGD-UHFFFAOYSA-N	303477	US10138226, Example 2-16-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 100.0							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303477	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303477&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363772	381752211							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582277	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)N1CCCCC1 |r|	InChI=1S/C29H35F3N4O2/c1-19-15-22(18-28(2,3)17-19)36-25-16-20(26(37)35-13-5-4-6-14-35)7-12-24(25)34-27(36)33-21-8-10-23(11-9-21)38-29(30,31)32/h7-12,16,19,22H,4-6,13-15,17-18H2,1-3H3,(H,33,34)	UVYAFIUQGWMFTQ-UHFFFAOYSA-N	303478	BDBM303479::US10138226, Example 2-17	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 580							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303478&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363773	381752212							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582278	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)N1CCCCC1 |r|	InChI=1S/C29H35F3N4O2/c1-19-15-22(18-28(2,3)17-19)36-25-16-20(26(37)35-13-5-4-6-14-35)7-12-24(25)34-27(36)33-21-8-10-23(11-9-21)38-29(30,31)32/h7-12,16,19,22H,4-6,13-15,17-18H2,1-3H3,(H,33,34)	UVYAFIUQGWMFTQ-UHFFFAOYSA-N	303478	BDBM303479::US10138226, Example 2-17	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1100							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303478&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363773	381752212							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582279	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)N1CCCCC1 |r|	InChI=1S/C29H35F3N4O2/c1-19-15-22(18-28(2,3)17-19)36-25-16-20(26(37)35-13-5-4-6-14-35)7-12-24(25)34-27(36)33-21-8-10-23(11-9-21)38-29(30,31)32/h7-12,16,19,22H,4-6,13-15,17-18H2,1-3H3,(H,33,34)	UVYAFIUQGWMFTQ-UHFFFAOYSA-N	303480	US10138226, Example 2-17-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1900							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303480	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303480&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363799	381752214							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582280	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)NC1CCS(=O)(=O)CC1 |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;$|	InChI=1S/C29H35F3N4O4S/c1-18-14-22(17-28(2,3)16-18)36-25-15-19(26(37)33-21-10-12-41(38,39)13-11-21)4-9-24(25)35-27(36)34-20-5-7-23(8-6-20)40-29(30,31)32/h4-9,15,18,21-22H,10-14,16-17H2,1-3H3,(H,33,37)(H,34,35)	QQLQWDLGDZUJOY-UHFFFAOYSA-N	303481	US10138226, Example 2-18::BDBM303482	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5300							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303481&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363802	381752215							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582281	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)NC1CCS(=O)(=O)CC1 |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;$|	InChI=1S/C29H35F3N4O4S/c1-18-14-22(17-28(2,3)16-18)36-25-15-19(26(37)33-21-10-12-41(38,39)13-11-21)4-9-24(25)35-27(36)34-20-5-7-23(8-6-20)40-29(30,31)32/h4-9,15,18,21-22H,10-14,16-17H2,1-3H3,(H,33,37)(H,34,35)	QQLQWDLGDZUJOY-UHFFFAOYSA-N	303481	US10138226, Example 2-18::BDBM303482	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303481&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363802	381752215							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582282	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)NC1CCS(=O)(=O)CC1 |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;$|	InChI=1S/C29H35F3N4O4S/c1-18-14-22(17-28(2,3)16-18)36-25-15-19(26(37)33-21-10-12-41(38,39)13-11-21)4-9-24(25)35-27(36)34-20-5-7-23(8-6-20)40-29(30,31)32/h4-9,15,18,21-22H,10-14,16-17H2,1-3H3,(H,33,37)(H,34,35)	QQLQWDLGDZUJOY-UHFFFAOYSA-N	303483	US10138226, Example 2-18-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303483&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363760	381752217							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582283	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)NS(C)(=O)=O |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;$|	InChI=1S/C25H29F3N4O4S/c1-15-11-18(14-24(2,3)13-15)32-21-12-16(22(33)31-37(4,34)35)5-10-20(21)30-23(32)29-17-6-8-19(9-7-17)36-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,29,30)(H,31,33)	HGQNWNQKDXQVQR-UHFFFAOYSA-N	303484	US10138226, Example 2-19	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303484&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363820	381752218							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582284	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)N(C)C |r|	InChI=1S/C26H31F3N4O2/c1-16-12-19(15-25(2,3)14-16)33-22-13-17(23(34)32(4)5)6-11-21(22)31-24(33)30-18-7-9-20(10-8-18)35-26(27,28)29/h6-11,13,16,19H,12,14-15H2,1-5H3,(H,30,31)	JLPQKDRSRDLKFZ-UHFFFAOYSA-N	303485	BDBM303486::US10138226, Example 2-20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 100.0							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303485&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132084675	381752219							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582285	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)N(C)C |r|	InChI=1S/C26H31F3N4O2/c1-16-12-19(15-25(2,3)14-16)33-22-13-17(23(34)32(4)5)6-11-21(22)31-24(33)30-18-7-9-20(10-8-18)35-26(27,28)29/h6-11,13,16,19H,12,14-15H2,1-5H3,(H,30,31)	JLPQKDRSRDLKFZ-UHFFFAOYSA-N	303485	BDBM303486::US10138226, Example 2-20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 80.0							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303485&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132084675	381752219							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582286	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)N(C)C |r|	InChI=1S/C26H31F3N4O2/c1-16-12-19(15-25(2,3)14-16)33-22-13-17(23(34)32(4)5)6-11-21(22)31-24(33)30-18-7-9-20(10-8-18)35-26(27,28)29/h6-11,13,16,19H,12,14-15H2,1-5H3,(H,30,31)	JLPQKDRSRDLKFZ-UHFFFAOYSA-N	303487	US10138226, Example 2-20-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 200							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303487&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132084684	381752221							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582287	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)NCc1ccc(F)cc1 |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;$|	InChI=1S/C31H32F4N4O2/c1-19-14-24(17-30(2,3)16-19)39-27-15-21(28(40)36-18-20-4-7-22(32)8-5-20)6-13-26(27)38-29(39)37-23-9-11-25(12-10-23)41-31(33,34)35/h4-13,15,19,24H,14,16-18H2,1-3H3,(H,36,40)(H,37,38)	WTUKIFAIKCHAPF-UHFFFAOYSA-N	303488	US10138226, Example 2-21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303488&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132084683	381752222							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582288	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)Nc1ccc(F)cc1 |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;$|	InChI=1S/C30H30F4N4O2/c1-18-14-23(17-29(2,3)16-18)38-26-15-19(27(39)35-21-7-5-20(31)6-8-21)4-13-25(26)37-28(38)36-22-9-11-24(12-10-22)40-30(32,33)34/h4-13,15,18,23H,14,16-17H2,1-3H3,(H,35,39)(H,36,37)	MTFDMCQXCZOUOX-UHFFFAOYSA-N	303489	US10138226, Example 2-22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303489&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132084660	381752223							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582289	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)NC1CC1 |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;$|	InChI=1S/C27H31F3N4O2/c1-16-12-20(15-26(2,3)14-16)34-23-13-17(24(35)31-18-5-6-18)4-11-22(23)33-25(34)32-19-7-9-21(10-8-19)36-27(28,29)30/h4,7-11,13,16,18,20H,5-6,12,14-15H2,1-3H3,(H,31,35)(H,32,33)	GFAHDCVZBTTZBY-UHFFFAOYSA-N	303490	BDBM303491::US10138226, Example 2-23	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303490&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363763	381752224							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582290	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)NC1CC1 |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;$|	InChI=1S/C27H31F3N4O2/c1-16-12-20(15-26(2,3)14-16)34-23-13-17(24(35)31-18-5-6-18)4-11-22(23)33-25(34)32-19-7-9-21(10-8-19)36-27(28,29)30/h4,7-11,13,16,18,20H,5-6,12,14-15H2,1-3H3,(H,31,35)(H,32,33)	GFAHDCVZBTTZBY-UHFFFAOYSA-N	303490	BDBM303491::US10138226, Example 2-23	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303490&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363763	381752224							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582291	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)NC1CC1 |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;$|	InChI=1S/C27H31F3N4O2/c1-16-12-20(15-26(2,3)14-16)34-23-13-17(24(35)31-18-5-6-18)4-11-22(23)33-25(34)32-19-7-9-21(10-8-19)36-27(28,29)30/h4,7-11,13,16,18,20H,5-6,12,14-15H2,1-3H3,(H,31,35)(H,32,33)	GFAHDCVZBTTZBY-UHFFFAOYSA-N	303492	US10138226, Example 2-23-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303492&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363808	381752226							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582292	CCOC(=O)CCN(C)C(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C30H37F3N4O4/c1-6-40-26(38)13-14-36(5)27(39)20-7-12-24-25(16-20)37(22-15-19(2)17-29(3,4)18-22)28(35-24)34-21-8-10-23(11-9-21)41-30(31,32)33/h7-12,16,19,22H,6,13-15,17-18H2,1-5H3,(H,34,35)	AQDDTFOFVTXIRM-UHFFFAOYSA-N	303493	US10138226, Example 2-24	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303493&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132084666	381752227							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
582293	C[C@@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(=O)N(C)C |r|	InChI=1S/C26H31F3N4O2/c1-16-12-19(15-25(2,3)14-16)33-22-13-17(23(34)32(4)5)6-11-21(22)31-24(33)30-18-7-9-20(10-8-18)35-26(27,28)29/h6-11,13,16,19H,12,14-15H2,1-5H3,(H,30,31)	JLPQKDRSRDLKFZ-UHFFFAOYSA-N	303494	US10138226, Example 2-25	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 470							US Patent		10.7270/Q2N30010		aid1796149	US10138226	Rehwinkel, H; Bauser, M; Zimmermann, K; Kaulfus, S; Neuhaus, R	11/27/2018	3/29/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=303494	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=303494&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132084701	381752228							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617046	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC2)nc(NCC2CC2)n1	InChI=1S/C17H19F3N6/c18-17(19,20)13-3-1-2-12(23-13)14-24-15(21-8-10-4-5-10)26-16(25-14)22-9-11-6-7-11/h1-3,10-11H,4-9H2,(H2,21,22,24,25,26)	KNDBYTOOVAJFRN-UHFFFAOYSA-N	279854	US10028961, Compound 1::US10172864, Compound 1::US10946023, Compound 1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279854&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817069	378161425							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617049	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C19H23F3N6/c1-10(12-6-7-12)23-17-26-16(14-4-3-5-15(25-14)19(20,21)22)27-18(28-17)24-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,23,24,26,27,28)	KRSKURCJOGAEOS-UHFFFAOYSA-N	279855	US10028961, Compound 2::US10172864, Compound 2::US10946023, Compound 2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279855&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817076	378161426							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617052	CC(C)Nc1nc(NC(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C15H19F3N6/c1-8(2)19-13-22-12(23-14(24-13)20-9(3)4)10-6-5-7-11(21-10)15(16,17)18/h5-9H,1-4H3,(H2,19,20,22,23,24)	WDSFOQJWJKBMPM-UHFFFAOYSA-N	279856	US10028961, Compound 3::US10172864, Compound 3::US10946023, Compound 3	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279856&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817527	378161427							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617054	CC(C)(C)Nc1nc(NC(C)(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C17H23F3N6/c1-15(2,3)25-13-22-12(23-14(24-13)26-16(4,5)6)10-8-7-9-11(21-10)17(18,19)20/h7-9H,1-6H3,(H2,22,23,24,25,26)	GSAWFHLLQMRJAD-UHFFFAOYSA-N	279857	US10028961, Compound 4::BDBM279926::US10172864, Compound 76::US10946023, Compound 76	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279857&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466272	378161428							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617057	C[C@@H](Nc1nc(NCC(N)=O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C16H18F3N7O/c1-8(9-5-6-9)22-15-25-13(24-14(26-15)21-7-12(20)27)10-3-2-4-11(23-10)16(17,18)19/h2-4,8-9H,5-7H2,1H3,(H2,20,27)(H2,21,22,24,25,26)	YDQAYHKPLFMZEJ-UHFFFAOYSA-N	279858	US10028961, Compound 5::US10172864, Compound 5::US10946023, Compound 5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279858&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817530	378161429							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617058	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccccc1F)C1CC1 |r|	InChI=1S/C19H24FN5/c1-11(13-7-8-13)21-18-23-17(15-5-3-4-6-16(15)20)24-19(25-18)22-12(2)14-9-10-14/h3-6,11-14H,7-10H2,1-2H3,(H2,21,22,23,24,25)	SBWSJSCKQBEYEK-UHFFFAOYSA-N	279859	US10028961, Compound 77::US10028961, Compound 6::US10172864, Compound 77::US10946023, Compound 77	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279859&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817088	378161430							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617060	FC(F)(F)c1cccc(n1)-c1nc(NCC2CCC2)nc(NCC2CCC2)n1	InChI=1S/C19H23F3N6/c20-19(21,22)15-9-3-8-14(25-15)16-26-17(23-10-12-4-1-5-12)28-18(27-16)24-11-13-6-2-7-13/h3,8-9,12-13H,1-2,4-7,10-11H2,(H2,23,24,26,27,28)	VPNNRJRDRDIMTN-UHFFFAOYSA-N	279860	US10028961, Compound 7::US10172864, Compound 7::US10946023, Compound 7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279860&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466271	378161431							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617065	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC2)nc(NC2CCC2)n1	InChI=1S/C17H19F3N6/c18-17(19,20)13-9-3-8-12(23-13)14-24-15(21-10-4-1-5-10)26-16(25-14)22-11-6-2-7-11/h3,8-11H,1-2,4-7H2,(H2,21,22,24,25,26)	PVIJXHIYMYVGOF-UHFFFAOYSA-N	279862	US10028961, Compound 9::US10172864, Compound 9::US10946023, Compound 9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279862&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466412	378161433							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617068	C[C@@H](Nc1nc(NCC(C)(C)O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C18H23F3N6O/c1-10(11-7-8-11)23-16-26-14(25-15(27-16)22-9-17(2,3)28)12-5-4-6-13(24-12)18(19,20)21/h4-6,10-11,28H,7-9H2,1-3H3,(H2,22,23,25,26,27)	BMMLVEOASUDOHV-UHFFFAOYSA-N	279863	US10028961, Compound 79::US10028961, Compound 10::US10172864, Compound 79::US10946023, Compound 79	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279863&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817095	378161434							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617071	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(O)c1)C1CC1 |r|	InChI=1S/C19H25N5O/c1-11(13-6-7-13)20-18-22-17(15-4-3-5-16(25)10-15)23-19(24-18)21-12(2)14-8-9-14/h3-5,10-14,25H,6-9H2,1-2H3,(H2,20,21,22,23,24)	JCZPGZCYKZMOEK-UHFFFAOYSA-N	279864	US10028961, Compound 80::US10028961, Compound 11::US10172864, Compound 80::US10946023, Compound 80	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279864&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799184	378161435							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617074	CC(O)CNc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C17H21F3N6O/c1-9(27)8-21-15-24-14(12-4-3-5-13(23-12)17(18,19)20)25-16(26-15)22-10(2)11-6-7-11/h3-5,9-11,27H,6-8H2,1-2H3,(H2,21,22,24,25,26)	YADRVMCMMMHOSZ-UHFFFAOYSA-N	279865	US10028961, Compound 81::US10028961, Compound 12::US10172864, Compound 81::US10946023, Compound 81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279865&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817110	378161436							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617077	CC(C)C(C)Nc1nc(NC(C)C(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H27F3N6/c1-10(2)12(5)23-17-26-16(27-18(28-17)24-13(6)11(3)4)14-8-7-9-15(25-14)19(20,21)22/h7-13H,1-6H3,(H2,23,24,26,27,28)	OLELDTDOYATLQM-UHFFFAOYSA-N	279866	US10028961, Compound 13::US10172864, Compound 13::US10946023, Compound 13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279866&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466273	378161437							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617079	CC(O)CNc1nc(NCC(C)O)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C15H19F3N6O2/c1-8(25)6-19-13-22-12(23-14(24-13)20-7-9(2)26)10-4-3-5-11(21-10)15(16,17)18/h3-5,8-9,25-26H,6-7H2,1-2H3,(H2,19,20,22,23,24)	QYMUDBQWLSGBAS-UHFFFAOYSA-N	279867	US10028961, Compound 14::US10172864, Compound 14::US10946023, Compound 14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279867&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817085	378161438							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617082	C[C@@H](Nc1nc(NCC(C)=O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C17H19F3N6O/c1-9(27)8-21-15-24-14(12-4-3-5-13(23-12)17(18,19)20)25-16(26-15)22-10(2)11-6-7-11/h3-5,10-11H,6-8H2,1-2H3,(H2,21,22,24,25,26)	GZYMCQBNCUYDKE-UHFFFAOYSA-N	279868	US10028961, Compound 15::US10172864, Compound 15::US10946023, Compound 15	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279868&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817099	378161439							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617084	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(CO)c1)C1CC1 |r|	InChI=1S/C20H27N5O/c1-12(15-6-7-15)21-19-23-18(17-5-3-4-14(10-17)11-26)24-20(25-19)22-13(2)16-8-9-16/h3-5,10,12-13,15-16,26H,6-9,11H2,1-2H3,(H2,21,22,23,24,25)	DXDMRKXHWQBBBA-UHFFFAOYSA-N	279869	US10028961, Compound 82::US10028961, Compound 16::US10172864, Compound 82::US10946023, Compound 82	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279869&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817092	378161440							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617087	CC(C)[C@H](C)Nc1nc(N[C@@H](C)C(C)C)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C19H27F3N6/c1-10(2)12(5)23-17-26-16(27-18(28-17)24-13(6)11(3)4)14-8-7-9-15(25-14)19(20,21)22/h7-13H,1-6H3,(H2,23,24,26,27,28)	OLELDTDOYATLQM-UHFFFAOYSA-N	279870	US10028961, Compound 17::US10172864, Compound 17::US10946023, Compound 17	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279870&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817087	378161441							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617089	CC(C)[C@@H](C)Nc1nc(N[C@H](C)C(C)C)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C19H27F3N6/c1-10(2)12(5)23-17-26-16(27-18(28-17)24-13(6)11(3)4)14-8-7-9-15(25-14)19(20,21)22/h7-13H,1-6H3,(H2,23,24,26,27,28)	OLELDTDOYATLQM-UHFFFAOYSA-N	279871	US10028961, Compound 18::US10172864, Compound 18::US10946023, Compound 18	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279871&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817080	378161442							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617091	C[C@@H](Nc1nc(N[C@H](C)C2CCC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CCC1 |r|	InChI=1S/C21H27F3N6/c1-12(14-6-3-7-14)25-19-28-18(16-10-5-11-17(27-16)21(22,23)24)29-20(30-19)26-13(2)15-8-4-9-15/h5,10-15H,3-4,6-9H2,1-2H3,(H2,25,26,28,29,30)	HTFFUPGDRXDEIP-UHFFFAOYSA-N	279872	US10028961, Compound 19::US10172864, Compound 19::US10946023, Compound 19	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279872&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817233	378161443							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617093	C[C@@H](Nc1nc(N[C@@H](C)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C22H23F3N6/c1-13(15-7-4-3-5-8-15)26-20-29-19(17-9-6-10-18(28-17)22(23,24)25)30-21(31-20)27-14(2)16-11-12-16/h3-10,13-14,16H,11-12H2,1-2H3,(H2,26,27,29,30,31)	YJZZCQZAKQBAMU-UHFFFAOYSA-N	279873	US10028961, Compound 20::US10172864, Compound 20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279873&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817082	378161444							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617094	C[C@@H](Nc1nc(N[C@@H](C)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C22H23F3N6/c1-13(15-7-4-3-5-8-15)26-20-29-19(17-9-6-10-18(28-17)22(23,24)25)30-21(31-20)27-14(2)16-11-12-16/h3-10,13-14,16H,11-12H2,1-2H3,(H2,26,27,29,30,31)	YJZZCQZAKQBAMU-UHFFFAOYSA-N	279873	US10028961, Compound 20::US10172864, Compound 20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279873&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817082	378161444							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617097	C[C@@H](Nc1nc(NCc2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C21H21F3N6/c1-13(15-10-11-15)26-20-29-18(16-8-5-9-17(27-16)21(22,23)24)28-19(30-20)25-12-14-6-3-2-4-7-14/h2-9,13,15H,10-12H2,1H3,(H2,25,26,28,29,30)	IUYXTIDKXVUWDD-UHFFFAOYSA-N	279874	US10028961, Compound 21::US10172864, Compound 21::US10946023, Compound 21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279874&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817101	378161445							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617100	C[C@@H](Nc1nc(N[C@H](C)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C22H23F3N6/c1-13(15-7-4-3-5-8-15)26-20-29-19(17-9-6-10-18(28-17)22(23,24)25)30-21(31-20)27-14(2)16-11-12-16/h3-10,13-14,16H,11-12H2,1-2H3,(H2,26,27,29,30,31)	YJZZCQZAKQBAMU-UHFFFAOYSA-N	279875	US10028961, Compound 22::US10172864, Compound 22::US10946023, Compound 22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279875&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817118	378161446							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617103	C[C@@H](Nc1nc(N[C@@H]2C[C@H]2c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C23H23F3N6/c1-13(14-10-11-14)27-21-30-20(17-8-5-9-19(28-17)23(24,25)26)31-22(32-21)29-18-12-16(18)15-6-3-2-4-7-15/h2-9,13-14,16,18H,10-12H2,1H3,(H2,27,29,30,31,32)	MPVKJRGUFDYPQR-UHFFFAOYSA-N	279876	US10028961, Compound 23::US10172864, Compound 23::US10946023, Compound 23	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279876&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817033	378161447							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617105	C[C@@H](Nc1nc(NCc2ccccn2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H20F3N7/c1-12(13-8-9-13)26-19-29-17(15-6-4-7-16(27-15)20(21,22)23)28-18(30-19)25-11-14-5-2-3-10-24-14/h2-7,10,12-13H,8-9,11H2,1H3,(H2,25,26,28,29,30)	YMKOTGDUPIYQMS-UHFFFAOYSA-N	279877	US10028961, Compound 83::US10028961, Compound 24::US10172864, Compound 83::US10946023, Compound 83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279877&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817120	378161448							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617107	C[C@@H](Nc1nc(NC(C)c2ccccn2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C21H22F3N7/c1-12(14-9-10-14)26-19-29-18(16-7-5-8-17(28-16)21(22,23)24)30-20(31-19)27-13(2)15-6-3-4-11-25-15/h3-8,11-14H,9-10H2,1-2H3,(H2,26,27,29,30,31)	PVBOMIYGGWSXIY-UHFFFAOYSA-N	279878	US10028961, Compound 84::US10028961, Compound 25::US10172864, Compound 84::US10946023, Compound 84	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279878&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817107	378161449							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617109	C[C@@H](Nc1nc(N[C@@H](C)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)c1ccccc1 |r|	InChI=1S/C25H23F3N6/c1-16(18-10-5-3-6-11-18)29-23-32-22(20-14-9-15-21(31-20)25(26,27)28)33-24(34-23)30-17(2)19-12-7-4-8-13-19/h3-17H,1-2H3,(H2,29,30,32,33,34)	LBAZIFOJZOIFON-UHFFFAOYSA-N	279879	US10028961, Compound 26::US10172864, Compound 26::US10946023, Compound 26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279879&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817147	378161450							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617112	C[C@@H](Nc1nc(NC(C)c2cccc(c2)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C23H22F6N6/c1-12(14-9-10-14)30-20-33-19(17-7-4-8-18(32-17)23(27,28)29)34-21(35-20)31-13(2)15-5-3-6-16(11-15)22(24,25)26/h3-8,11-14H,9-10H2,1-2H3,(H2,30,31,33,34,35)	OUNUKDITMWXSMU-UHFFFAOYSA-N	279880	US10028961, Compound 27::US10172864, Compound 27::US10946023, Compound 27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279880&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817140	378161451							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617114	C[C@@H](Nc1nc(NC(C)c2cccc(F)c2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C22H22F4N6/c1-12(14-9-10-14)27-20-30-19(17-7-4-8-18(29-17)22(24,25)26)31-21(32-20)28-13(2)15-5-3-6-16(23)11-15/h3-8,11-14H,9-10H2,1-2H3,(H2,27,28,30,31,32)	JYVZJECTMOHVFX-UHFFFAOYSA-N	279881	US10028961, Compound 28::US10172864, Compound 28::US10946023, Compound 28	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279881&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817145	378161452							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617115	C[C@@H](Nc1nc(NC(C)c2cccc(F)c2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C22H22F4N6/c1-12(14-9-10-14)27-20-30-19(17-7-4-8-18(29-17)22(24,25)26)31-21(32-20)28-13(2)15-5-3-6-16(23)11-15/h3-8,11-14H,9-10H2,1-2H3,(H2,27,28,30,31,32)	JYVZJECTMOHVFX-UHFFFAOYSA-N	279881	US10028961, Compound 28::US10172864, Compound 28::US10946023, Compound 28	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279881&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817145	378161452							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617117	C[C@@H](Nc1nc(NC(=O)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C21H19F3N6O/c1-12(13-10-11-13)25-19-27-17(15-8-5-9-16(26-15)21(22,23)24)28-20(30-19)29-18(31)14-6-3-2-4-7-14/h2-9,12-13H,10-11H2,1H3,(H2,25,27,28,29,30,31)	IQRLKQDCDTZTJN-UHFFFAOYSA-N	279882	US10028961, Compound 29::US10172864, Compound 29::US10946023, Compound 29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279882&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817153	378161453							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617119	C[C@@H](Nc1nc(NC2(CC2)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C23H23F3N6/c1-14(15-10-11-15)27-20-29-19(17-8-5-9-18(28-17)23(24,25)26)30-21(31-20)32-22(12-13-22)16-6-3-2-4-7-16/h2-9,14-15H,10-13H2,1H3,(H2,27,29,30,31,32)	MMQKYUIBTNHALE-UHFFFAOYSA-N	279883	US10028961, Compound 85::US10028961, Compound 30::US10172864, Compound 85::US10946023, Compound 85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279883&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466563	378161454							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617122	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	JWMKUJAOIPXYIG-UHFFFAOYSA-N	279884	US10028961, Compound 31::US10172864, Compound 31::US10946023, Compound 31	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279884&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86580656	378161455							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617125	COc1ccc(F)c(c1)-c1nc(NC(C)C)nc(NC(C)(C)C#N)n1	InChI=1S/C17H21FN6O/c1-10(2)20-15-21-14(12-8-11(25-5)6-7-13(12)18)22-16(23-15)24-17(3,4)9-19/h6-8,10H,1-5H3,(H2,20,21,22,23,24)	JTBPNQFDWIZOKU-UHFFFAOYSA-N	279885	US10028961, Compound 32::US10172864, Compound 32::US10946023, Compound 32	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279885&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799404	378161456							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617127	C[C@H](Nc1nc(N[C@@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C19H23F3N6/c1-10(12-6-7-12)23-17-26-16(14-4-3-5-15(25-14)19(20,21)22)27-18(28-17)24-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,23,24,26,27,28)	KRSKURCJOGAEOS-UHFFFAOYSA-N	279886	US10028961, Compound 33::US10172864, Compound 33::US10946023, Compound 33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279886&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817234	378161457							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617129	C[C@@H](Nc1nc(N[C@@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C19H23F3N6/c1-10(12-6-7-12)23-17-26-16(14-4-3-5-15(25-14)19(20,21)22)27-18(28-17)24-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,23,24,26,27,28)	KRSKURCJOGAEOS-UHFFFAOYSA-N	279887	US10028961, Compound 34::US10172864, Compound 34::US10946023, Compound 34	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279887	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279887&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817526	378161458							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617131	CC(C)Nc1nc(NC(C)(C)C#N)nc(n1)-c1cc(O)ccc1F	InChI=1S/C16H19FN6O/c1-9(2)19-14-20-13(11-7-10(24)5-6-12(11)17)21-15(22-14)23-16(3,4)8-18/h5-7,9,24H,1-4H3,(H2,19,20,21,22,23)	ZKCSHTWHAVTEDI-UHFFFAOYSA-N	279888	US10028961, Compound 35::US10172864, Compound 35::US10946023, Compound 35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279888&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817394	378161459							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617133	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3CC3C2)nc(NC2CC3CC3C2)n1	InChI=1S/C21H23F3N6/c22-21(23,24)17-3-1-2-16(27-17)18-28-19(25-14-6-10-4-11(10)7-14)30-20(29-18)26-15-8-12-5-13(12)9-15/h1-3,10-15H,4-9H2,(H2,25,26,28,29,30)	DLSICRMIGDILCI-UHFFFAOYSA-N	279889	US10028961, Compound 36::US10172864, Compound 36::US10946023, Compound 36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279889&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466413	378161460							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617134	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3CC3C2)nc(NC2CC3CC3C2)n1	InChI=1S/C21H23F3N6/c22-21(23,24)17-3-1-2-16(27-17)18-28-19(25-14-6-10-4-11(10)7-14)30-20(29-18)26-15-8-12-5-13(12)9-15/h1-3,10-15H,4-9H2,(H2,25,26,28,29,30)	DLSICRMIGDILCI-UHFFFAOYSA-N	279889	US10028961, Compound 36::US10172864, Compound 36::US10946023, Compound 36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279889&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466413	378161460							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617136	C[C@@H](Nc1nc(NC(C)(C)C#N)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C18H20F3N7/c1-10(11-7-8-11)23-15-25-14(26-16(27-15)28-17(2,3)9-22)12-5-4-6-13(24-12)18(19,20)21/h4-6,10-11H,7-8H2,1-3H3,(H2,23,25,26,27,28)	QDXATNXZLOTYRV-UHFFFAOYSA-N	279890	US10028961, Compound 87::US10028961, Compound 37::US10172864, Compound 87::US10946023, Compound 87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279890&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817466	378161461							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617138	C[C@@H](Nc1nc(NC2CCOC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C18H21F3N6O/c1-10(11-5-6-11)22-16-25-15(13-3-2-4-14(24-13)18(19,20)21)26-17(27-16)23-12-7-8-28-9-12/h2-4,10-12H,5-9H2,1H3,(H2,22,23,25,26,27)	RWSYXAQFFAQAEC-UHFFFAOYSA-N	279891	US10028961, Compound 38::US10172864, Compound 38::US10946023, Compound 38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279891&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817537	378161462							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617140	CCCC(C)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C19H25F3N6/c1-4-6-11(2)23-17-26-16(14-7-5-8-15(25-14)19(20,21)22)27-18(28-17)24-12(3)13-9-10-13/h5,7-8,11-13H,4,6,9-10H2,1-3H3,(H2,23,24,26,27,28)	PETSAMLQOBIHSS-UHFFFAOYSA-N	279892	US10028961, Compound 39::US10172864, Compound 39::US10946023, Compound 39	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279892&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799007	378161463							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617142	CC(Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C#N |r|	InChI=1S/C17H18F3N7/c1-9(8-21)22-15-25-14(12-4-3-5-13(24-12)17(18,19)20)26-16(27-15)23-10(2)11-6-7-11/h3-5,9-11H,6-7H2,1-2H3,(H2,22,23,25,26,27)	YBMLCUNTUFVOKD-UHFFFAOYSA-N	279893	US10028961, Compound 40::US10172864, Compound 40::US10946023, Compound 40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279893&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817588	378161464							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617144	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H23F7N6/c22-19(23)8-4-12(5-9-19)29-17-32-16(14-2-1-3-15(31-14)21(26,27)28)33-18(34-17)30-13-6-10-20(24,25)11-7-13/h1-3,12-13H,4-11H2,(H2,29,30,32,33,34)	LYMZYGUSADHRMY-UHFFFAOYSA-N	279894	US10028961, Compound 41::US10172864, Compound 41::US10946023, Compound 41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279894&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466415	378161465							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617146	C[C@@H](Nc1nc(N[C@H]2CCCC[C@@H]2O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H25F3N6O/c1-11(12-9-10-12)24-18-27-17(14-6-4-8-16(25-14)20(21,22)23)28-19(29-18)26-13-5-2-3-7-15(13)30/h4,6,8,11-13,15,30H,2-3,5,7,9-10H2,1H3,(H2,24,26,27,28,29)	DNYYBCNJEMMGNA-UHFFFAOYSA-N	279895	US10028961, Compound 42::US10172864, Compound 42::US10946023, Compound 42	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279895&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817502	378161466							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617148	C[C@@H](Nc1nc(N[C@H]2CCC[C@H]2O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C19H23F3N6O/c1-10(11-8-9-11)23-17-26-16(13-5-3-7-15(24-13)19(20,21)22)27-18(28-17)25-12-4-2-6-14(12)29/h3,5,7,10-12,14,29H,2,4,6,8-9H2,1H3,(H2,23,25,26,27,28)	UHUHOBBXPQIHRY-UHFFFAOYSA-N	279896	US10028961, Compound 43::US10172864, Compound 43::US10946023, Compound 43	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279896&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			122440835	378161467							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617150	COCC(C)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C18H23F3N6O/c1-10(9-28-3)22-16-25-15(13-5-4-6-14(24-13)18(19,20)21)26-17(27-16)23-11(2)12-7-8-12/h4-6,10-12H,7-9H2,1-3H3,(H2,22,23,25,26,27)	LUBVUPNBKHPQTK-UHFFFAOYSA-N	279897	US10028961, Compound 44::US10172864, Compound 44::US10946023, Compound 44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279897&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817089	378161468							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617152	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(Cl)n1)C1CC1 |r|	InChI=1S/C18H23ClN6/c1-10(12-6-7-12)20-17-23-16(14-4-3-5-15(19)22-14)24-18(25-17)21-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,20,21,23,24,25)	GTMXNXATSGQGCH-UHFFFAOYSA-N	279898	US10028961, Compound 45::US10172864, Compound 45::US10946023, Compound 45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279898&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799064	378161469							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617154	CCN(CC)c1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(Cl)n1 |r|	InChI=1S/C17H23ClN6/c1-4-24(5-2)17-22-15(13-7-6-8-14(18)20-13)21-16(23-17)19-11(3)12-9-10-12/h6-8,11-12H,4-5,9-10H2,1-3H3,(H,19,21,22,23)	XYQKRMAHYVIZRA-UHFFFAOYSA-N	279899	US10028961, Compound 88::US10028961, Compound 46::US10172864, Compound 88::US10946023, Compound 88	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279899&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817084	378161470							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617156	C[C@@H](Nc1nc(N[C@H](C)C(O)=O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C17H19F3N6O2/c1-8(10-6-7-10)21-15-24-13(25-16(26-15)22-9(2)14(27)28)11-4-3-5-12(23-11)17(18,19)20/h3-5,8-10H,6-7H2,1-2H3,(H,27,28)(H2,21,22,24,25,26)	OVEVKHHIEURDIP-UHFFFAOYSA-N	279900	US10028961, Compound 47::US10172864, Compound 47::US10946023, Compound 47	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279900&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817090	378161471							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617157	C[C@@H](Nc1nc(N[C@H](C)C(=O)N(C)C)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C19H24F3N7O/c1-10(12-8-9-12)23-17-26-15(13-6-5-7-14(25-13)19(20,21)22)27-18(28-17)24-11(2)16(30)29(3)4/h5-7,10-12H,8-9H2,1-4H3,(H2,23,24,26,27,28)	GFSAAPLIWHCOTJ-UHFFFAOYSA-N	279901	US10028961, Compound 48::US10172864, Compound 48::US10946023, Compound 48	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279901	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279901&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817102	378161472							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617158	CC(C)(CO)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H20F5N7O/c1-18(2,10-33)32-17-30-15(12-5-4-6-13(28-12)20(23,24)25)29-16(31-17)27-11-7-8-26-14(9-11)19(3,21)22/h4-9,33H,10H2,1-3H3,(H2,26,27,29,30,31,32)	VPNOHMBISYXVRN-UHFFFAOYSA-N	279902	US10028961, Compound 49::US10172864, Compound 49::US10946023, Compound 49	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279902&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817105	378161473							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617160	C[C@@H](Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H23F5N6/c1-11(12-5-6-12)26-17-29-16(14-3-2-4-15(28-14)20(23,24)25)30-18(31-17)27-13-7-9-19(21,22)10-8-13/h2-4,11-13H,5-10H2,1H3,(H2,26,27,29,30,31)	VHWMBKQPXXLOFJ-UHFFFAOYSA-N	279903	US10028961, Compound 50::US10172864, Compound 50	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279903&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817596	378161474							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617161	C[C@@H](Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H23F5N6/c1-11(12-5-6-12)26-17-29-16(14-3-2-4-15(28-14)20(23,24)25)30-18(31-17)27-13-7-9-19(21,22)10-8-13/h2-4,11-13H,5-10H2,1H3,(H2,26,27,29,30,31)	VHWMBKQPXXLOFJ-UHFFFAOYSA-N	279903	US10028961, Compound 50::US10172864, Compound 50	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279903&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817596	378161474							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617163	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)N1CCC1)C1CC1 |r|	InChI=1S/C21H29N7/c1-13(15-7-8-15)22-20-25-19(26-21(27-20)23-14(2)16-9-10-16)17-5-3-6-18(24-17)28-11-4-12-28/h3,5-6,13-16H,4,7-12H2,1-2H3,(H2,22,23,25,26,27)	HSMKSLUXGRHQJU-UHFFFAOYSA-N	279904	US10028961, Compound 89::US10028961, Compound 51::US10172864, Compound 89::US10946023, Compound 89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279904&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817093	378161475							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617165	FC(F)(F)c1cccc(n1)-c1nc(NC2CCOC2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H19F5N6O/c19-17(20)6-4-10(8-17)24-15-27-14(12-2-1-3-13(26-12)18(21,22)23)28-16(29-15)25-11-5-7-30-9-11/h1-3,10-11H,4-9H2,(H2,24,25,27,28,29)	HBTPVNIAECEEFE-UHFFFAOYSA-N	279905	US10028961, Compound 52::US10172864, Compound 52::US10946023, Compound 52	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279905&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466560	378161476							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617166	FC(F)(F)c1cccc(n1)-c1nc(NC2CCOC2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H19F5N6O/c19-17(20)6-4-10(8-17)24-15-27-14(12-2-1-3-13(26-12)18(21,22)23)28-16(29-15)25-11-5-7-30-9-11/h1-3,10-11H,4-9H2,(H2,24,25,27,28,29)	HBTPVNIAECEEFE-UHFFFAOYSA-N	279905	US10028961, Compound 52::US10172864, Compound 52::US10946023, Compound 52	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279905&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466560	378161476							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617167	CC(C)(C)OC(=O)N1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C23H28F5N7O2/c1-21(2,3)37-20(36)35-10-8-14(12-35)30-19-33-17(15-5-4-6-16(31-15)23(26,27)28)32-18(34-19)29-13-7-9-22(24,25)11-13/h4-6,13-14H,7-12H2,1-3H3,(H2,29,30,32,33,34)	MDGYQOGSIDPTTI-UHFFFAOYSA-N	279906	US10028961, Compound 90::US10028961, Compound 53::US10172864, Compound 90::US10946023, Compound 90	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279906&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466417	378161477							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617168	CC(C)(C)OC(=O)N1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C23H28F5N7O2/c1-21(2,3)37-20(36)35-10-8-14(12-35)30-19-33-17(15-5-4-6-16(31-15)23(26,27)28)32-18(34-19)29-13-7-9-22(24,25)11-13/h4-6,13-14H,7-12H2,1-3H3,(H2,29,30,32,33,34)	MDGYQOGSIDPTTI-UHFFFAOYSA-N	279906	US10028961, Compound 90::US10028961, Compound 53::US10172864, Compound 90::US10946023, Compound 90	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279906&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466417	378161477							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617169	FC(F)(F)c1cccc(n1)-c1nc(NC2CCNC2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H20F5N7/c19-17(20)6-4-10(8-17)25-15-28-14(12-2-1-3-13(27-12)18(21,22)23)29-16(30-15)26-11-5-7-24-9-11/h1-3,10-11,24H,4-9H2,(H2,25,26,28,29,30)	IXFTZPSJWXQNPG-UHFFFAOYSA-N	279907	US10028961, Compound 91::US10028961, Compound 54::US10172864, Compound 91::US10946023, Compound 91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279907&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466416	378161478							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617170	FC(F)(F)c1cccc(n1)-c1nc(NC2CCNC2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H20F5N7/c19-17(20)6-4-10(8-17)25-15-28-14(12-2-1-3-13(27-12)18(21,22)23)29-16(30-15)26-11-5-7-24-9-11/h1-3,10-11,24H,4-9H2,(H2,25,26,28,29,30)	IXFTZPSJWXQNPG-UHFFFAOYSA-N	279907	US10028961, Compound 91::US10028961, Compound 54::US10172864, Compound 91::US10946023, Compound 91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279907&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466416	378161478							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617171	CC(=O)N1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H22F5N7O/c1-11(33)32-8-6-13(10-32)27-18-30-16(14-3-2-4-15(28-14)20(23,24)25)29-17(31-18)26-12-5-7-19(21,22)9-12/h2-4,12-13H,5-10H2,1H3,(H2,26,27,29,30,31)	YVNPRQSYAIXEEB-UHFFFAOYSA-N	279908	US10028961, Compound 55::US10172864, Compound 55::US10946023, Compound 55	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279908&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817503	378161479							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617172	CC(=O)N1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H22F5N7O/c1-11(33)32-8-6-13(10-32)27-18-30-16(14-3-2-4-15(28-14)20(23,24)25)29-17(31-18)26-12-5-7-19(21,22)9-12/h2-4,12-13H,5-10H2,1H3,(H2,26,27,29,30,31)	YVNPRQSYAIXEEB-UHFFFAOYSA-N	279908	US10028961, Compound 55::US10172864, Compound 55::US10946023, Compound 55	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279908&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817503	378161479							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617173	CS(=O)(=O)N1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H22F5N7O2S/c1-34(32,33)31-8-6-12(10-31)26-17-29-15(13-3-2-4-14(27-13)19(22,23)24)28-16(30-17)25-11-5-7-18(20,21)9-11/h2-4,11-12H,5-10H2,1H3,(H2,25,26,28,29,30)	CCAAECSCQISUPX-UHFFFAOYSA-N	279909	US10028961, Compound 56::US10172864, Compound 56::US10946023, Compound 56	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279909	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279909&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817533	378161480							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617174	CS(=O)(=O)N1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H22F5N7O2S/c1-34(32,33)31-8-6-12(10-31)26-17-29-15(13-3-2-4-14(27-13)19(22,23)24)28-16(30-17)25-11-5-7-18(20,21)9-11/h2-4,11-12H,5-10H2,1H3,(H2,25,26,28,29,30)	CCAAECSCQISUPX-UHFFFAOYSA-N	279909	US10028961, Compound 56::US10172864, Compound 56::US10946023, Compound 56	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279909	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279909&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817533	378161480							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617175	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccnc1)C1CC1 |r|	InChI=1S/C18H24N6/c1-11(13-5-6-13)20-17-22-16(15-4-3-9-19-10-15)23-18(24-17)21-12(2)14-7-8-14/h3-4,9-14H,5-8H2,1-2H3,(H2,20,21,22,23,24)	GWYWLYIKFLDUMQ-UHFFFAOYSA-N	279910	US10028961, Compound 92::US10028961, Compound 57::US10172864, Compound 92::US10946023, Compound 92	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279910&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466562	378161481							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617176	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccnc1)C1CC1 |r|	InChI=1S/C18H24N6/c1-11(13-5-6-13)20-17-22-16(15-4-3-9-19-10-15)23-18(24-17)21-12(2)14-7-8-14/h3-4,9-14H,5-8H2,1-2H3,(H2,20,21,22,23,24)	GWYWLYIKFLDUMQ-UHFFFAOYSA-N	279910	US10028961, Compound 92::US10028961, Compound 57::US10172864, Compound 92::US10946023, Compound 92	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279910&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466562	378161481							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617177	C[C@@H](Nc1nc(NC2CC3(C2)CC(F)(F)C3)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C21H23F5N6/c1-11(12-5-6-12)27-17-30-16(14-3-2-4-15(29-14)21(24,25)26)31-18(32-17)28-13-7-19(8-13)9-20(22,23)10-19/h2-4,11-13H,5-10H2,1H3,(H2,27,28,30,31,32)	RMLKOVRFURMNDJ-UHFFFAOYSA-N	279911	US10028961, Compound 58::US10172864, Compound 58::US10946023, Compound 58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279911&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817535	378161482							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617178	C[C@@H](Nc1nc(NC2CC3(C2)CC(F)(F)C3)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C21H23F5N6/c1-11(12-5-6-12)27-17-30-16(14-3-2-4-15(29-14)21(24,25)26)31-18(32-17)28-13-7-19(8-13)9-20(22,23)10-19/h2-4,11-13H,5-10H2,1H3,(H2,27,28,30,31,32)	RMLKOVRFURMNDJ-UHFFFAOYSA-N	279911	US10028961, Compound 58::US10172864, Compound 58::US10946023, Compound 58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279911&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817535	378161482							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617179	COC(=O)N1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H22F5N7O2/c1-34-18(33)32-8-6-12(10-32)27-17-30-15(13-3-2-4-14(28-13)20(23,24)25)29-16(31-17)26-11-5-7-19(21,22)9-11/h2-4,11-12H,5-10H2,1H3,(H2,26,27,29,30,31)	HBUVPQWRGSFFAM-UHFFFAOYSA-N	279912	US10028961, Compound 59::US10172864, Compound 59::US10946023, Compound 59	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279912&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799339	378161483							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617180	C[C@@H](Nc1nc(NC2Cc3ccccc3C2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C23H23F3N6/c1-13(14-9-10-14)27-21-30-20(18-7-4-8-19(29-18)23(24,25)26)31-22(32-21)28-17-11-15-5-2-3-6-16(15)12-17/h2-8,13-14,17H,9-12H2,1H3,(H2,27,28,30,31,32)	QNCFEEZALZKPFF-UHFFFAOYSA-N	279913	US10028961, Compound 60::US10172864, Compound 60::US10946023, Compound 60	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279913&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466561	378161484							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617181	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccccn1)C1CC1 |r|	InChI=1S/C18H24N6/c1-11(13-6-7-13)20-17-22-16(15-5-3-4-10-19-15)23-18(24-17)21-12(2)14-8-9-14/h3-5,10-14H,6-9H2,1-2H3,(H2,20,21,22,23,24)	LQIAKXUZNSTYRL-UHFFFAOYSA-N	279914	US10028961, Compound 93::US10028961, Compound 61::US10172864, Compound 93::US10946023, Compound 93	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279914&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817412	378161485							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617183	COCC(COC)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C19H25F3N6O2/c1-11(12-7-8-12)23-17-26-16(14-5-4-6-15(25-14)19(20,21)22)27-18(28-17)24-13(9-29-2)10-30-3/h4-6,11-13H,7-10H2,1-3H3,(H2,23,24,26,27,28)	UALNWZBGYZUTGB-UHFFFAOYSA-N	279915	US10028961, Compound 63::US10172864, Compound 63::US10946023, Compound 63	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279915&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817501	378161486							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617184	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(Cl)c1)C1CC1 |r|	InChI=1S/C19H24ClN5/c1-11(13-6-7-13)21-18-23-17(15-4-3-5-16(20)10-15)24-19(25-18)22-12(2)14-8-9-14/h3-5,10-14H,6-9H2,1-2H3,(H2,21,22,23,24,25)	MUAWGTSYRLJHHM-UHFFFAOYSA-N	279916	US10028961, Compound 64::US10172864, Compound 64::US10946023, Compound 64	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279916&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817534	378161487							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617185	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccccc1Cl)C1CC1 |r|	InChI=1S/C19H24ClN5/c1-11(13-7-8-13)21-18-23-17(15-5-3-4-6-16(15)20)24-19(25-18)22-12(2)14-9-10-14/h3-6,11-14H,7-10H2,1-2H3,(H2,21,22,23,24,25)	BFRTUOCWCLMKIN-UHFFFAOYSA-N	279917	US10028961, Compound 94::US10028961, Compound 66::US10172864, Compound 94::US10946023, Compound 94	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279917&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817340	378161488							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617186	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccncc1)C1CC1 |r|	InChI=1S/C18H24N6/c1-11(13-3-4-13)20-17-22-16(15-7-9-19-10-8-15)23-18(24-17)21-12(2)14-5-6-14/h7-14H,3-6H2,1-2H3,(H2,20,21,22,23,24)	JZOVQRSRIPIGKZ-UHFFFAOYSA-N	279918	US10028961, Compound 95::US10028961, Compound 67::US10172864, Compound 95::US10946023, Compound 95	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279918	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279918&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817342	378161489							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617191	CC(C)(C)Nc1nc(NC(C)(C)C)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C17H23F3N6/c1-15(2,3)25-13-22-12(23-14(24-13)26-16(4,5)6)10-8-7-9-11(21-10)17(18,19)20/h7-9H,1-6H3,(H2,22,23,24,25,26)	GSAWFHLLQMRJAD-UHFFFAOYSA-N	279857	US10028961, Compound 4::BDBM279926::US10172864, Compound 76::US10946023, Compound 76	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279857&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466272	378161428							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617194	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccccc1F)C1CC1 |r|	InChI=1S/C19H24FN5/c1-11(13-7-8-13)21-18-23-17(15-5-3-4-6-16(15)20)24-19(25-18)22-12(2)14-9-10-14/h3-6,11-14H,7-10H2,1-2H3,(H2,21,22,23,24,25)	SBWSJSCKQBEYEK-UHFFFAOYSA-N	279859	US10028961, Compound 77::US10028961, Compound 6::US10172864, Compound 77::US10946023, Compound 77	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279859&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817088	378161430							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617198	C[C@@H](Nc1nc(NCC(C)(C)O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C18H23F3N6O/c1-10(11-7-8-11)23-16-26-14(25-15(27-16)22-9-17(2,3)28)12-5-4-6-13(24-12)18(19,20)21/h4-6,10-11,28H,7-9H2,1-3H3,(H2,22,23,25,26,27)	BMMLVEOASUDOHV-UHFFFAOYSA-N	279863	US10028961, Compound 79::US10028961, Compound 10::US10172864, Compound 79::US10946023, Compound 79	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279863&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817095	378161434							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617201	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(O)c1)C1CC1 |r|	InChI=1S/C19H25N5O/c1-11(13-6-7-13)20-18-22-17(15-4-3-5-16(25)10-15)23-19(24-18)21-12(2)14-8-9-14/h3-5,10-14,25H,6-9H2,1-2H3,(H2,20,21,22,23,24)	JCZPGZCYKZMOEK-UHFFFAOYSA-N	279864	US10028961, Compound 80::US10028961, Compound 11::US10172864, Compound 80::US10946023, Compound 80	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279864&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799184	378161435							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617204	CC(O)CNc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C17H21F3N6O/c1-9(27)8-21-15-24-14(12-4-3-5-13(23-12)17(18,19)20)25-16(26-15)22-10(2)11-6-7-11/h3-5,9-11,27H,6-8H2,1-2H3,(H2,21,22,24,25,26)	YADRVMCMMMHOSZ-UHFFFAOYSA-N	279865	US10028961, Compound 81::US10028961, Compound 12::US10172864, Compound 81::US10946023, Compound 81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279865&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817110	378161436							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617207	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(CO)c1)C1CC1 |r|	InChI=1S/C20H27N5O/c1-12(15-6-7-15)21-19-23-18(17-5-3-4-14(10-17)11-26)24-20(25-19)22-13(2)16-8-9-16/h3-5,10,12-13,15-16,26H,6-9,11H2,1-2H3,(H2,21,22,23,24,25)	DXDMRKXHWQBBBA-UHFFFAOYSA-N	279869	US10028961, Compound 82::US10028961, Compound 16::US10172864, Compound 82::US10946023, Compound 82	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279869&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817092	378161440							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617210	C[C@@H](Nc1nc(NCc2ccccn2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H20F3N7/c1-12(13-8-9-13)26-19-29-17(15-6-4-7-16(27-15)20(21,22)23)28-18(30-19)25-11-14-5-2-3-10-24-14/h2-7,10,12-13H,8-9,11H2,1H3,(H2,25,26,28,29,30)	YMKOTGDUPIYQMS-UHFFFAOYSA-N	279877	US10028961, Compound 83::US10028961, Compound 24::US10172864, Compound 83::US10946023, Compound 83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279877&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817120	378161448							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617212	C[C@@H](Nc1nc(NC(C)c2ccccn2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C21H22F3N7/c1-12(14-9-10-14)26-19-29-18(16-7-5-8-17(28-16)21(22,23)24)30-20(31-19)27-13(2)15-6-3-4-11-25-15/h3-8,11-14H,9-10H2,1-2H3,(H2,26,27,29,30,31)	PVBOMIYGGWSXIY-UHFFFAOYSA-N	279878	US10028961, Compound 84::US10028961, Compound 25::US10172864, Compound 84::US10946023, Compound 84	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279878&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817107	378161449							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617214	C[C@@H](Nc1nc(NC2(CC2)c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C23H23F3N6/c1-14(15-10-11-15)27-20-29-19(17-8-5-9-18(28-17)23(24,25)26)30-21(31-20)32-22(12-13-22)16-6-3-2-4-7-16/h2-9,14-15H,10-13H2,1H3,(H2,27,29,30,31,32)	MMQKYUIBTNHALE-UHFFFAOYSA-N	279883	US10028961, Compound 85::US10028961, Compound 30::US10172864, Compound 85::US10946023, Compound 85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279883&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466563	378161454							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617217	CC(C)CNc1nc(NC(C)(C)C#N)nc(n1)-c1cc(O)ccc1F	InChI=1S/C17H21FN6O/c1-10(2)8-20-15-21-14(12-7-11(25)5-6-13(12)18)22-16(23-15)24-17(3,4)9-19/h5-7,10,25H,8H2,1-4H3,(H2,20,21,22,23,24)	SXDPYZOSOGORMF-UHFFFAOYSA-N	279936	US10028961, Compound 86::US10172864, Compound 86::US10946023, Compound 86	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279936&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817467	378161495							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617218	CC(C)CNc1nc(NC(C)(C)C#N)nc(n1)-c1cc(O)ccc1F	InChI=1S/C17H21FN6O/c1-10(2)8-20-15-21-14(12-7-11(25)5-6-13(12)18)22-16(23-15)24-17(3,4)9-19/h5-7,10,25H,8H2,1-4H3,(H2,20,21,22,23,24)	SXDPYZOSOGORMF-UHFFFAOYSA-N	279936	US10028961, Compound 86::US10172864, Compound 86::US10946023, Compound 86	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279936&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817467	378161495							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617220	C[C@@H](Nc1nc(NC(C)(C)C#N)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C18H20F3N7/c1-10(11-7-8-11)23-15-25-14(26-16(27-15)28-17(2,3)9-22)12-5-4-6-13(24-12)18(19,20)21/h4-6,10-11H,7-8H2,1-3H3,(H2,23,25,26,27,28)	QDXATNXZLOTYRV-UHFFFAOYSA-N	279890	US10028961, Compound 87::US10028961, Compound 37::US10172864, Compound 87::US10946023, Compound 87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279890&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817466	378161461							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617222	CCN(CC)c1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(Cl)n1 |r|	InChI=1S/C17H23ClN6/c1-4-24(5-2)17-22-15(13-7-6-8-14(18)20-13)21-16(23-17)19-11(3)12-9-10-12/h6-8,11-12H,4-5,9-10H2,1-3H3,(H,19,21,22,23)	XYQKRMAHYVIZRA-UHFFFAOYSA-N	279899	US10028961, Compound 88::US10028961, Compound 46::US10172864, Compound 88::US10946023, Compound 88	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279899&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817084	378161470							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617224	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)N1CCC1)C1CC1 |r|	InChI=1S/C21H29N7/c1-13(15-7-8-15)22-20-25-19(26-21(27-20)23-14(2)16-9-10-16)17-5-3-6-18(24-17)28-11-4-12-28/h3,5-6,13-16H,4,7-12H2,1-2H3,(H2,22,23,25,26,27)	HSMKSLUXGRHQJU-UHFFFAOYSA-N	279904	US10028961, Compound 89::US10028961, Compound 51::US10172864, Compound 89::US10946023, Compound 89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279904&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817093	378161475							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617226	CC(C)(C)OC(=O)N1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C23H28F5N7O2/c1-21(2,3)37-20(36)35-10-8-14(12-35)30-19-33-17(15-5-4-6-16(31-15)23(26,27)28)32-18(34-19)29-13-7-9-22(24,25)11-13/h4-6,13-14H,7-12H2,1-3H3,(H2,29,30,32,33,34)	MDGYQOGSIDPTTI-UHFFFAOYSA-N	279906	US10028961, Compound 90::US10028961, Compound 53::US10172864, Compound 90::US10946023, Compound 90	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279906&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466417	378161477							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617227	CC(C)(C)OC(=O)N1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C23H28F5N7O2/c1-21(2,3)37-20(36)35-10-8-14(12-35)30-19-33-17(15-5-4-6-16(31-15)23(26,27)28)32-18(34-19)29-13-7-9-22(24,25)11-13/h4-6,13-14H,7-12H2,1-3H3,(H2,29,30,32,33,34)	MDGYQOGSIDPTTI-UHFFFAOYSA-N	279906	US10028961, Compound 90::US10028961, Compound 53::US10172864, Compound 90::US10946023, Compound 90	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279906&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466417	378161477							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617228	FC(F)(F)c1cccc(n1)-c1nc(NC2CCNC2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H20F5N7/c19-17(20)6-4-10(8-17)25-15-28-14(12-2-1-3-13(27-12)18(21,22)23)29-16(30-15)26-11-5-7-24-9-11/h1-3,10-11,24H,4-9H2,(H2,25,26,28,29,30)	IXFTZPSJWXQNPG-UHFFFAOYSA-N	279907	US10028961, Compound 91::US10028961, Compound 54::US10172864, Compound 91::US10946023, Compound 91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279907&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466416	378161478							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617229	FC(F)(F)c1cccc(n1)-c1nc(NC2CCNC2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H20F5N7/c19-17(20)6-4-10(8-17)25-15-28-14(12-2-1-3-13(27-12)18(21,22)23)29-16(30-15)26-11-5-7-24-9-11/h1-3,10-11,24H,4-9H2,(H2,25,26,28,29,30)	IXFTZPSJWXQNPG-UHFFFAOYSA-N	279907	US10028961, Compound 91::US10028961, Compound 54::US10172864, Compound 91::US10946023, Compound 91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279907&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466416	378161478							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617230	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccnc1)C1CC1 |r|	InChI=1S/C18H24N6/c1-11(13-5-6-13)20-17-22-16(15-4-3-9-19-10-15)23-18(24-17)21-12(2)14-7-8-14/h3-4,9-14H,5-8H2,1-2H3,(H2,20,21,22,23,24)	GWYWLYIKFLDUMQ-UHFFFAOYSA-N	279910	US10028961, Compound 92::US10028961, Compound 57::US10172864, Compound 92::US10946023, Compound 92	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279910&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466562	378161481							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617231	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccnc1)C1CC1 |r|	InChI=1S/C18H24N6/c1-11(13-5-6-13)20-17-22-16(15-4-3-9-19-10-15)23-18(24-17)21-12(2)14-7-8-14/h3-4,9-14H,5-8H2,1-2H3,(H2,20,21,22,23,24)	GWYWLYIKFLDUMQ-UHFFFAOYSA-N	279910	US10028961, Compound 92::US10028961, Compound 57::US10172864, Compound 92::US10946023, Compound 92	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279910&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466562	378161481							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617232	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccccn1)C1CC1 |r|	InChI=1S/C18H24N6/c1-11(13-6-7-13)20-17-22-16(15-5-3-4-10-19-15)23-18(24-17)21-12(2)14-8-9-14/h3-5,10-14H,6-9H2,1-2H3,(H2,20,21,22,23,24)	LQIAKXUZNSTYRL-UHFFFAOYSA-N	279914	US10028961, Compound 93::US10028961, Compound 61::US10172864, Compound 93::US10946023, Compound 93	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279914&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817412	378161485							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617233	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccccc1Cl)C1CC1 |r|	InChI=1S/C19H24ClN5/c1-11(13-7-8-13)21-18-23-17(15-5-3-4-6-16(15)20)24-19(25-18)22-12(2)14-9-10-14/h3-6,11-14H,7-10H2,1-2H3,(H2,21,22,23,24,25)	BFRTUOCWCLMKIN-UHFFFAOYSA-N	279917	US10028961, Compound 94::US10028961, Compound 66::US10172864, Compound 94::US10946023, Compound 94	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279917&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817340	378161488							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617234	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccncc1)C1CC1 |r|	InChI=1S/C18H24N6/c1-11(13-3-4-13)20-17-22-16(15-7-9-19-10-8-15)23-18(24-17)21-12(2)14-5-6-14/h7-14H,3-6H2,1-2H3,(H2,20,21,22,23,24)	JZOVQRSRIPIGKZ-UHFFFAOYSA-N	279918	US10028961, Compound 95::US10028961, Compound 67::US10172864, Compound 95::US10946023, Compound 95	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279918	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279918&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817342	378161489							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617235	CN1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H22F5N7/c1-31-8-6-12(10-31)26-17-29-15(13-3-2-4-14(27-13)19(22,23)24)28-16(30-17)25-11-5-7-18(20,21)9-11/h2-4,11-12H,5-10H2,1H3,(H2,25,26,28,29,30)	FKUYTXAMGGWNHC-UHFFFAOYSA-N	279946	US10028961, Compound 326::US10028961, Compound 96::US10172864, Compound 96::US10946023, Compound 326	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279946	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279946&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817313	378161496							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617236	C[C@@H](Nc1nc(NC(C(F)(F)F)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C14H10ClF9N6/c1-5(12(16,17)18)25-10-27-8(6-3-2-4-7(15)26-6)28-11(30-10)29-9(13(19,20)21)14(22,23)24/h2-5,9H,1H3,(H2,25,27,28,29,30)	VTJODCQTJUKOPV-UHFFFAOYSA-N	279947	US10028961, Compound 100::US10172864, Compound 100::US10946023, Compound 100	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279947	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279947&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817515	378161497							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617238	C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)	QCZAWDGAVJMPTA-UHFFFAOYSA-N	279948	US10028961, Compound 101::US10172864, Compound 101::US10946023, Compound 101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279948	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279948&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817422	378161498							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617239	C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)	QCZAWDGAVJMPTA-UHFFFAOYSA-N	279948	US10028961, Compound 101::US10172864, Compound 101::US10946023, Compound 101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279948	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279948&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817422	378161498							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617241	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(N[C@@H]2CCC(F)(F)C2)n1 |r|	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	JWMKUJAOIPXYIG-UHFFFAOYSA-N	279949	US10028961, Compound 102::US10172864, Compound 102::US10946023, Compound 102	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279949	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279949&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799093	378161499							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617243	CCC(Nc1nc(NC(CC)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C16H17ClF6N6/c1-3-9(15(18,19)20)25-13-27-12(8-6-5-7-11(17)24-8)28-14(29-13)26-10(4-2)16(21,22)23/h5-7,9-10H,3-4H2,1-2H3,(H2,25,26,27,28,29)	SDUBFPITPDQUSW-UHFFFAOYSA-N	279950	US10028961, Compound 103::US10172864, Compound 103::US10946023, Compound 103	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279950	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279950&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817517	378161500							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617245	CC[C@@H](Nc1nc(N[C@H](CC)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C16H17ClF6N6/c1-3-9(15(18,19)20)25-13-27-12(8-6-5-7-11(17)24-8)28-14(29-13)26-10(4-2)16(21,22)23/h5-7,9-10H,3-4H2,1-2H3,(H2,25,26,27,28,29)	SDUBFPITPDQUSW-UHFFFAOYSA-N	279951	US10028961, Compound 104::US10172864, Compound 104::US10946023, Compound 104	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279951	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279951&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817514	378161501							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617247	CC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C20H22F6N6/c1-18(21,22)14-4-2-3-13(29-14)15-30-16(27-11-5-7-19(23,24)9-11)32-17(31-15)28-12-6-8-20(25,26)10-12/h2-4,11-12H,5-10H2,1H3,(H2,27,28,30,31,32)	RZUPVAWGQZNFEZ-UHFFFAOYSA-N	279952	US10028961, Compound 105::US10172864, Compound 105::US10946023, Compound 105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279952	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279952&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817521	378161502							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617248	CC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C20H22F6N6/c1-18(21,22)14-4-2-3-13(29-14)15-30-16(27-11-5-7-19(23,24)9-11)32-17(31-15)28-12-6-8-20(25,26)10-12/h2-4,11-12H,5-10H2,1H3,(H2,27,28,30,31,32)	RZUPVAWGQZNFEZ-UHFFFAOYSA-N	279952	US10028961, Compound 105::US10172864, Compound 105::US10946023, Compound 105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279952	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279952&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817521	378161502							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617250	Fc1cc(F)cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-n2ccc(n2)C(F)(F)F)c1	InChI=1S/C17H12F7N7/c18-8-3-9(19)5-10(4-8)25-13-27-14(26-11-6-16(20,21)7-11)29-15(28-13)31-2-1-12(30-31)17(22,23)24/h1-5,11H,6-7H2,(H2,25,26,27,28,29)	XSFFZJKIWXEYIL-UHFFFAOYSA-N	279953	US10028961, Compound 106::US10172864, Compound 106::US10946023, Compound 106	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279953	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279953&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799077	378161503							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617252	CC(Nc1nc(Nc2cc(F)cc(F)c2)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C16H11F8N7/c1-7(15(19,20)21)25-12-27-13(26-10-5-8(17)4-9(18)6-10)29-14(28-12)31-3-2-11(30-31)16(22,23)24/h2-7H,1H3,(H2,25,26,27,28,29)	AQCLVWSTMGVZRR-UHFFFAOYSA-N	279954	US10028961, Compound 107::US10172864, Compound 107::US10946023, Compound 107	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279954	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279954&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817516	378161504							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617254	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-n2ccc(n2)C(F)(F)F)c1	InChI=1S/C18H14F7N7/c19-9-5-10(20)7-12(6-9)27-15-28-14(26-11-1-3-17(21,22)8-11)29-16(30-15)32-4-2-13(31-32)18(23,24)25/h2,4-7,11H,1,3,8H2,(H2,26,27,28,29,30)	UFZDFINJOJHYMD-UHFFFAOYSA-N	279955	US10028961, Compound 108::US10172864, Compound 108::US10946023, Compound 108	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279955	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279955&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817518	378161505							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617256	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cncc(Cl)n2)c1	InChI=1S/C18H14ClF4N7/c19-14-8-24-7-13(27-14)15-28-16(25-11-1-2-18(22,23)6-11)30-17(29-15)26-12-4-9(20)3-10(21)5-12/h3-5,7-8,11H,1-2,6H2,(H2,25,26,28,29,30)	FQSFRGSJYCFQDI-UHFFFAOYSA-N	279956	US10028961, Compound 109::US10172864, Compound 109::US10946023, Compound 109	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279956	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279956&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799583	378161506							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617258	CCC(Nc1nc(NC(CC)C2CC2)nc(n1)-c1cccc(Cl)n1)C1CC1	InChI=1S/C20H27ClN6/c1-3-14(12-8-9-12)23-19-25-18(16-6-5-7-17(21)22-16)26-20(27-19)24-15(4-2)13-10-11-13/h5-7,12-15H,3-4,8-11H2,1-2H3,(H2,23,24,25,26,27)	SDVGLHHVYYZRJZ-UHFFFAOYSA-N	279957	US10028961, Compound 110::US10172864, Compound 110::US10946023, Compound 110	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279957	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279957&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817125	378161507							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617259	CCC(Nc1nc(NC(CC)C2CC2)nc(n1)-c1cccc(Cl)n1)C1CC1	InChI=1S/C20H27ClN6/c1-3-14(12-8-9-12)23-19-25-18(16-6-5-7-17(21)22-16)26-20(27-19)24-15(4-2)13-10-11-13/h5-7,12-15H,3-4,8-11H2,1-2H3,(H2,23,24,25,26,27)	SDVGLHHVYYZRJZ-UHFFFAOYSA-N	279957	US10028961, Compound 110::US10172864, Compound 110::US10946023, Compound 110	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279957	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279957&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817125	378161507							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617261	FC(F)(F)c1cccc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(N[C@@H]2CCC(F)(F)C2)n1 |r|	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	JWMKUJAOIPXYIG-UHFFFAOYSA-N	279958	US10028961, Compound 111::US10172864, Compound 111::US10946023, Compound 111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279958	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279958&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817150	378161508							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617263	Fc1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-n2ccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C19H14F6N8/c20-11-5-10(9-26)6-13(7-11)28-16-29-15(27-12-1-3-18(21,22)8-12)30-17(31-16)33-4-2-14(32-33)19(23,24)25/h2,4-7,12H,1,3,8H2,(H2,27,28,29,30,31)	GOMGSGWMVHCJSA-UHFFFAOYSA-N	279959	US10028961, Compound 112::US10172864, Compound 112::US10946023, Compound 112	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279959	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279959&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817138	378161509							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617265	FC1(F)CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(Cl)n1	InChI=1S/C18H19ClF4N6/c19-13-3-1-2-12(26-13)14-27-15(24-10-4-6-17(20,21)8-10)29-16(28-14)25-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,24,25,27,28,29)	WFTCEDYVKXKHBE-UHFFFAOYSA-N	279960	US10028961, Compound 113::US10172864, Compound 113::US10946023, Compound 113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279960	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279960&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817141	378161510							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617266	FC1(F)CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(Cl)n1	InChI=1S/C18H19ClF4N6/c19-13-3-1-2-12(26-13)14-27-15(24-10-4-6-17(20,21)8-10)29-16(28-14)25-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,24,25,27,28,29)	WFTCEDYVKXKHBE-UHFFFAOYSA-N	279960	US10028961, Compound 113::US10172864, Compound 113::US10946023, Compound 113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279960	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279960&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817141	378161510							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617268	C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1csc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C13H11F9N6S/c1-4(11(14,15)16)23-9-26-7(6-3-29-8(25-6)13(20,21)22)27-10(28-9)24-5(2)12(17,18)19/h3-5H,1-2H3,(H2,23,24,26,27,28)	ZNKBYOAOGUGDDM-UHFFFAOYSA-N	279961	US10028961, Compound 114::US10172864, Compound 114::US10946023, Compound 114	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279961	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279961&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817136	378161511							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617270	FC(F)(F)c1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(Cl)n2)ccn1	InChI=1S/C19H15ClF5N7/c20-14-3-1-2-12(29-14)15-30-16(27-10-5-7-26-13(8-10)19(23,24)25)32-17(31-15)28-11-4-6-18(21,22)9-11/h1-3,5,7-8,11H,4,6,9H2,(H2,26,27,28,30,31,32)	GCDKECOSGNFZAP-UHFFFAOYSA-N	279962	US10028961, Compound 115::US10172864, Compound 115::US10946023, Compound 115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279962	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279962&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798735	378161512							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617271	FC(F)(F)c1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(Cl)n2)ccn1	InChI=1S/C19H15ClF5N7/c20-14-3-1-2-12(29-14)15-30-16(27-10-5-7-26-13(8-10)19(23,24)25)32-17(31-15)28-11-4-6-18(21,22)9-11/h1-3,5,7-8,11H,4,6,9H2,(H2,26,27,28,30,31,32)	GCDKECOSGNFZAP-UHFFFAOYSA-N	279962	US10028961, Compound 115::US10172864, Compound 115::US10946023, Compound 115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279962	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279962&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798735	378161512							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617273	FC(F)(F)c1cncc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C19H14F8N8/c20-17(21)3-1-10(6-17)31-16-34-14(11-7-28-8-13(32-11)19(25,26)27)33-15(35-16)30-9-2-4-29-12(5-9)18(22,23)24/h2,4-5,7-8,10H,1,3,6H2,(H2,29,30,31,33,34,35)	ONCVYPCVWHYEJW-UHFFFAOYSA-N	279963	US10028961, Compound 116::US10172864, Compound 116::US10946023, Compound 116	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279963	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279963&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799248	378161513							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617275	CC(C)(C)Nc1nc(Nc2cccc(c2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H18F3N7/c1-19(2,3)30-18-28-16(14-8-5-9-15(26-14)20(21,22)23)27-17(29-18)25-13-7-4-6-12(10-13)11-24/h4-10H,1-3H3,(H2,25,27,28,29,30)	CZMWMJOWERHTGF-UHFFFAOYSA-N	279964	US10028961, Compound 117::US10172864, Compound 117::US10946023, Compound 117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279964	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279964&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799236	378161514							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617276	CC(C)(C)Nc1nc(Nc2cccc(c2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H18F3N7/c1-19(2,3)30-18-28-16(14-8-5-9-15(26-14)20(21,22)23)27-17(29-18)25-13-7-4-6-12(10-13)11-24/h4-10H,1-3H3,(H2,25,27,28,29,30)	CZMWMJOWERHTGF-UHFFFAOYSA-N	279964	US10028961, Compound 117::US10172864, Compound 117::US10946023, Compound 117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279964	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279964&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799236	378161514							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617278	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(N[C@H]2CCC(F)(F)C2)n1 |r|	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	JWMKUJAOIPXYIG-UHFFFAOYSA-N	279965	US10028961, Compound 118::US10172864, Compound 118::US10946023, Compound 118	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279965	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279965&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817143	378161515							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617280	CC(Nc1nc(Nc2cc(F)cc(c2)C#N)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C17H11F7N8/c1-8(16(19,20)21)26-13-28-14(27-11-5-9(7-25)4-10(18)6-11)30-15(29-13)32-3-2-12(31-32)17(22,23)24/h2-6,8H,1H3,(H2,26,27,28,29,30)	WXBOZLIIKJDCRJ-UHFFFAOYSA-N	279966	US10028961, Compound 119::US10172864, Compound 119::US10946023, Compound 119	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279966	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279966&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817540	378161516							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617282	Fc1cc(F)cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2cncc(Cl)n2)c1	InChI=1S/C17H12ClF4N7/c18-13-7-23-6-12(26-13)14-27-15(24-10-2-8(19)1-9(20)3-10)29-16(28-14)25-11-4-17(21,22)5-11/h1-3,6-7,11H,4-5H2,(H2,24,25,27,28,29)	DJUDMNYUQIPAHU-UHFFFAOYSA-N	279967	US10028961, Compound 120::US10172864, Compound 120::US10946023, Compound 120	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279967	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279967&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799523	378161517							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617284	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-n1ccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C17H22F3N7/c1-9(11-3-4-11)21-14-23-15(22-10(2)12-5-6-12)25-16(24-14)27-8-7-13(26-27)17(18,19)20/h7-12H,3-6H2,1-2H3,(H2,21,22,23,24,25)	ZFCNVKABVPLJJM-UHFFFAOYSA-N	279968	US10028961, Compound 121::US10172864, Compound 121::US10946023, Compound 121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279968	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279968&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817536	378161518							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617285	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-n1ccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C17H22F3N7/c1-9(11-3-4-11)21-14-23-15(22-10(2)12-5-6-12)25-16(24-14)27-8-7-13(26-27)17(18,19)20/h7-12H,3-6H2,1-2H3,(H2,21,22,23,24,25)	ZFCNVKABVPLJJM-UHFFFAOYSA-N	279968	US10028961, Compound 121::US10172864, Compound 121::US10946023, Compound 121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279968	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279968&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817536	378161518							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617287	Fc1cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2nc(cs2)C(F)(F)F)cc(c1)C#N	InChI=1S/C18H11F6N7S/c19-9-1-8(6-25)2-10(3-9)26-15-29-13(14-28-12(7-32-14)18(22,23)24)30-16(31-15)27-11-4-17(20,21)5-11/h1-3,7,11H,4-5H2,(H2,26,27,29,30,31)	MHTOHBOHQAYWJP-UHFFFAOYSA-N	279969	US10028961, Compound 122::US10172864, Compound 122::US10946023, Compound 122	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279969	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279969&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799023	378161519							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617289	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)c1	InChI=1S/C20H15F7N6/c21-10-6-11(22)8-13(7-10)29-18-32-16(14-2-1-3-15(30-14)20(25,26)27)31-17(33-18)28-12-4-5-19(23,24)9-12/h1-3,6-8,12H,4-5,9H2,(H2,28,29,31,32,33)	DTFRDAWQNHNMEU-UHFFFAOYSA-N	279970	US10028961, Compound 123::US10172864, Compound 123::US10946023, Compound 123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279970	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279970&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798777	378161520							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617290	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)c1	InChI=1S/C20H15F7N6/c21-10-6-11(22)8-13(7-10)29-18-32-16(14-2-1-3-15(30-14)20(25,26)27)31-17(33-18)28-12-4-5-19(23,24)9-12/h1-3,6-8,12H,4-5,9H2,(H2,28,29,31,32,33)	DTFRDAWQNHNMEU-UHFFFAOYSA-N	279970	US10028961, Compound 123::US10172864, Compound 123::US10946023, Compound 123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279970	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279970&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798777	378161520							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617292	Fc1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C21H15F6N7/c22-12-6-11(10-28)7-14(8-12)30-19-33-17(15-2-1-3-16(31-15)21(25,26)27)32-18(34-19)29-13-4-5-20(23,24)9-13/h1-3,6-8,13H,4-5,9H2,(H2,29,30,32,33,34)	NTKHRYLRDAXKRH-UHFFFAOYSA-N	279971	US10028961, Compound 124::US10172864, Compound 124::US10946023, Compound 124	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279971	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279971&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799282	378161521							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617293	Fc1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C21H15F6N7/c22-12-6-11(10-28)7-14(8-12)30-19-33-17(15-2-1-3-16(31-15)21(25,26)27)32-18(34-19)29-13-4-5-20(23,24)9-13/h1-3,6-8,13H,4-5,9H2,(H2,29,30,32,33,34)	NTKHRYLRDAXKRH-UHFFFAOYSA-N	279971	US10028961, Compound 124::US10172864, Compound 124::US10946023, Compound 124	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279971	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279971&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799282	378161521							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617295	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)CC3)nc(n2)-c2cccc(n2)C(F)(F)F)c1	InChI=1S/C21H17F7N6/c22-11-8-12(23)10-14(9-11)30-19-33-17(15-2-1-3-16(31-15)21(26,27)28)32-18(34-19)29-13-4-6-20(24,25)7-5-13/h1-3,8-10,13H,4-7H2,(H2,29,30,32,33,34)	PEKCODXRCQZWOA-UHFFFAOYSA-N	279972	US10028961, Compound 125::US10172864, Compound 125::US10946023, Compound 125	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279972	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279972&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817565	378161522							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617296	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)CC3)nc(n2)-c2cccc(n2)C(F)(F)F)c1	InChI=1S/C21H17F7N6/c22-11-8-12(23)10-14(9-11)30-19-33-17(15-2-1-3-16(31-15)21(26,27)28)32-18(34-19)29-13-4-6-20(24,25)7-5-13/h1-3,8-10,13H,4-7H2,(H2,29,30,32,33,34)	PEKCODXRCQZWOA-UHFFFAOYSA-N	279972	US10028961, Compound 125::US10172864, Compound 125::US10946023, Compound 125	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279972	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279972&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817565	378161522							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617298	FC(F)(F)c1ccn(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H14F7N7/c16-13(17)3-7(4-13)23-10-25-11(24-8-5-14(18,19)6-8)27-12(26-10)29-2-1-9(28-29)15(20,21)22/h1-2,7-8H,3-6H2,(H2,23,24,25,26,27)	NYHCCPXGTKQDAW-UHFFFAOYSA-N	279973	US10028961, Compound 126::US10172864, Compound 126::US10946023, Compound 126	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279973	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279973&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817544	378161523							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617299	FC(F)(F)c1ccn(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H14F7N7/c16-13(17)3-7(4-13)23-10-25-11(24-8-5-14(18,19)6-8)27-12(26-10)29-2-1-9(28-29)15(20,21)22/h1-2,7-8H,3-6H2,(H2,23,24,25,26,27)	NYHCCPXGTKQDAW-UHFFFAOYSA-N	279973	US10028961, Compound 126::US10172864, Compound 126::US10946023, Compound 126	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279973	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279973&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817544	378161523							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617301	FC1(F)CCC(C1)Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(Cl)n1	InChI=1S/C22H19ClF2N8/c23-17-3-1-2-15(30-17)18-31-19(33-20(32-18)29-14-4-6-22(24,25)11-14)28-13-5-9-27-16(10-13)21(12-26)7-8-21/h1-3,5,9-10,14H,4,6-8,11H2,(H2,27,28,29,31,32,33)	ZENVCUIOSQAXHI-UHFFFAOYSA-N	279974	US10028961, Compound 127::US10172864, Compound 127::US10946023, Compound 127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279974	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279974&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799128	378161524							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617302	FC1(F)CCC(C1)Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(Cl)n1	InChI=1S/C22H19ClF2N8/c23-17-3-1-2-15(30-17)18-31-19(33-20(32-18)29-14-4-6-22(24,25)11-14)28-13-5-9-27-16(10-13)21(12-26)7-8-21/h1-3,5,9-10,14H,4,6-8,11H2,(H2,27,28,29,31,32,33)	ZENVCUIOSQAXHI-UHFFFAOYSA-N	279974	US10028961, Compound 127::US10172864, Compound 127::US10946023, Compound 127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279974	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279974&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799128	378161524							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617304	FC(F)(F)c1csc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H13F7N6S/c16-13(17)1-6(2-13)23-11-26-9(10-25-8(5-29-10)15(20,21)22)27-12(28-11)24-7-3-14(18,19)4-7/h5-7H,1-4H2,(H2,23,24,26,27,28)	DSJXHLDOLTTWGN-UHFFFAOYSA-N	279975	US10028961, Compound 128::US10172864, Compound 128::US10946023, Compound 128	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279975	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279975&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817465	378161525							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617305	FC(F)(F)c1csc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H13F7N6S/c16-13(17)1-6(2-13)23-11-26-9(10-25-8(5-29-10)15(20,21)22)27-12(28-11)24-7-3-14(18,19)4-7/h5-7H,1-4H2,(H2,23,24,26,27,28)	DSJXHLDOLTTWGN-UHFFFAOYSA-N	279975	US10028961, Compound 128::US10172864, Compound 128::US10946023, Compound 128	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279975	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279975&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817465	378161525							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617307	FC1(F)CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cncc(Cl)n1	InChI=1S/C17H18ClF4N7/c18-12-8-23-7-11(26-12)13-27-14(24-9-1-3-16(19,20)5-9)29-15(28-13)25-10-2-4-17(21,22)6-10/h7-10H,1-6H2,(H2,24,25,27,28,29)	RZIGAQYBYPZUMX-UHFFFAOYSA-N	279976	US10028961, Compound 129::US10172864, Compound 129::US10946023, Compound 129	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279976	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279976&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817433	378161526							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617309	CC(Nc1nc(NC(C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)	QCZAWDGAVJMPTA-UHFFFAOYSA-N	279977	US10028961, Compound 130::US10172864, Compound 130::US10946023, Compound 130	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279977	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279977&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817435	378161527							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617310	CC(Nc1nc(NC(C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)	QCZAWDGAVJMPTA-UHFFFAOYSA-N	279977	US10028961, Compound 130::US10172864, Compound 130::US10946023, Compound 130	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279977	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279977&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817435	378161527							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617312	Clc1cccc(n1)-c1nc(NC(C2CC2)C2CC2)nc(NC(C2CC2)C2CC2)n1	InChI=1S/C22H27ClN6/c23-17-3-1-2-16(24-17)20-27-21(25-18(12-4-5-12)13-6-7-13)29-22(28-20)26-19(14-8-9-14)15-10-11-15/h1-3,12-15,18-19H,4-11H2,(H2,25,26,27,28,29)	UYZPRJVBJGBQLI-UHFFFAOYSA-N	279978	US10028961, Compound 131::US10172864, Compound 131::US10946023, Compound 131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279978	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279978&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817455	378161528							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617313	Clc1cccc(n1)-c1nc(NC(C2CC2)C2CC2)nc(NC(C2CC2)C2CC2)n1	InChI=1S/C22H27ClN6/c23-17-3-1-2-16(24-17)20-27-21(25-18(12-4-5-12)13-6-7-13)29-22(28-20)26-19(14-8-9-14)15-10-11-15/h1-3,12-15,18-19H,4-11H2,(H2,25,26,27,28,29)	UYZPRJVBJGBQLI-UHFFFAOYSA-N	279978	US10028961, Compound 131::US10172864, Compound 131::US10946023, Compound 131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279978	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279978&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817455	378161528							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617315	Fc1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2nc(cs2)C(F)(F)F)cc(c1)[N+]#[C-]	InChI=1S/C19H13F6N7S/c1-26-11-4-9(20)5-12(6-11)28-17-31-14(15-29-13(8-33-15)19(23,24)25)30-16(32-17)27-10-2-3-18(21,22)7-10/h4-6,8,10H,2-3,7H2,(H2,27,28,30,31,32)	KEBOTYHGXMTVHD-UHFFFAOYSA-N	279979	US10028961, Compound 132::US10172864, Compound 132	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279979	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279979&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123723292	378161529							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617317	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1 |r|	InChI=1S/C23H19F5N8/c24-22(25)6-4-14(11-22)32-20-35-18(15-2-1-3-16(33-15)23(26,27)28)34-19(36-20)31-13-5-9-30-17(10-13)21(12-29)7-8-21/h1-3,5,9-10,14H,4,6-8,11H2,(H2,30,31,32,34,35,36)	FQOVWGJWJAOWBO-UHFFFAOYSA-N	279980	US10028961, Compound 133::US10172864, Compound 133::US10946023, Compound 133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279980	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279980&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817510	378161530							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617319	CC(Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C20H16ClF3N8/c1-11(20(22,23)24)27-17-30-16(13-3-2-4-15(21)29-13)31-18(32-17)28-12-5-8-26-14(9-12)19(10-25)6-7-19/h2-5,8-9,11H,6-7H2,1H3,(H2,26,27,28,30,31,32)	CFSIYYWIWLPLNQ-UHFFFAOYSA-N	279981	US10028961, Compound 134::US10172864, Compound 134::US10946023, Compound 134	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279981	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279981&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817443	378161531							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617320	CC(Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C20H16ClF3N8/c1-11(20(22,23)24)27-17-30-16(13-3-2-4-15(21)29-13)31-18(32-17)28-12-5-8-26-14(9-12)19(10-25)6-7-19/h2-5,8-9,11H,6-7H2,1H3,(H2,26,27,28,30,31,32)	CFSIYYWIWLPLNQ-UHFFFAOYSA-N	279981	US10028961, Compound 134::US10172864, Compound 134::US10946023, Compound 134	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279981	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279981&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817443	378161531							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617322	C[C@@H](Nc1nc(NC2CCc3ccccc23)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C23H23F3N6/c1-13(14-9-10-14)27-21-30-20(18-7-4-8-19(28-18)23(24,25)26)31-22(32-21)29-17-12-11-15-5-2-3-6-16(15)17/h2-8,13-14,17H,9-12H2,1H3,(H2,27,29,30,31,32)	SNCVLWHFGQJUFT-UHFFFAOYSA-N	279982	US10028961, Compound 135::US10172864, Compound 135::US10946023, Compound 135	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279982	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279982&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817509	378161532							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617323	C[C@@H](Nc1nc(N[C@@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)	QCZAWDGAVJMPTA-UHFFFAOYSA-N	279983	US10028961, Compound 136::US10172864, Compound 136::US10946023, Compound 136	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279983	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279983&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817448	378161533							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617324	C[C@@H](Nc1nc(N[C@@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)	QCZAWDGAVJMPTA-UHFFFAOYSA-N	279983	US10028961, Compound 136::US10172864, Compound 136::US10946023, Compound 136	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279983	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279983&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817448	378161533							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617326	FC(F)(F)c1cccc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1 |r|	InChI=1S/C23H19F5N8/c24-22(25)6-4-14(11-22)32-20-35-18(15-2-1-3-16(33-15)23(26,27)28)34-19(36-20)31-13-5-9-30-17(10-13)21(12-29)7-8-21/h1-3,5,9-10,14H,4,6-8,11H2,(H2,30,31,32,34,35,36)	FQOVWGJWJAOWBO-UHFFFAOYSA-N	279984	US10028961, Compound 137::US10172864, Compound 137::US10946023, Compound 137	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279984	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279984&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799135	378161534							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617328	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H18F7N7/c19-16(20)3-1-9(5-16)27-14-30-13(11-7-26-8-12(29-11)18(23,24)25)31-15(32-14)28-10-2-4-17(21,22)6-10/h7-10H,1-6H2,(H2,27,28,30,31,32)	YWUBJNPVIIBDPD-UHFFFAOYSA-N	279985	US10028961, Compound 138::US10172864, Compound 138::US10946023, Compound 138	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279985	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279985&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817513	378161535							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617330	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2nc(F)ccc2F)c1	InChI=1S/C19H14F6N6/c20-9-5-10(21)7-12(6-9)27-18-30-16(15-13(22)1-2-14(23)28-15)29-17(31-18)26-11-3-4-19(24,25)8-11/h1-2,5-7,11H,3-4,8H2,(H2,26,27,29,30,31)	NODRFDKTDCPLDT-UHFFFAOYSA-N	279986	US10028961, Compound 139::US10172864, Compound 139::US10946023, Compound 139	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279986	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279986&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817539	378161536							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617332	Fc1cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-n2ccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C18H12F6N8/c19-10-3-9(8-25)4-11(5-10)26-14-28-15(27-12-6-17(20,21)7-12)30-16(29-14)32-2-1-13(31-32)18(22,23)24/h1-5,12H,6-7H2,(H2,26,27,28,29,30)	LDOFFBDPIFZNNG-UHFFFAOYSA-N	279987	US10028961, Compound 140::US10172864, Compound 140::US10946023, Compound 140	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279987	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279987&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799247	378161537							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617334	CC(Nc1nc(NC(C)C(F)(F)F)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C13H12F9N7/c1-5(11(14,15)16)23-8-25-9(24-6(2)12(17,18)19)27-10(26-8)29-4-3-7(28-29)13(20,21)22/h3-6H,1-2H3,(H2,23,24,25,26,27)	FYQXPMJBVPBLMP-UHFFFAOYSA-N	279988	US10028961, Compound 141::US10172864, Compound 141::US10946023, Compound 141	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279988	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279988&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817582	378161538							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617336	C[C@H](Nc1nc(N[C@@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)	QCZAWDGAVJMPTA-UHFFFAOYSA-N	279989	US10028961, Compound 142::US10172864, Compound 142::US10946023, Compound 142	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279989	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279989&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817339	378161539							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617337	C[C@H](Nc1nc(N[C@@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)	QCZAWDGAVJMPTA-UHFFFAOYSA-N	279989	US10028961, Compound 142::US10172864, Compound 142::US10946023, Compound 142	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279989	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279989&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817339	378161539							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617339	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(5-7-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-8-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	ACLXKIHIMONNBV-UHFFFAOYSA-N	279990	US10028961, Compound 143::US10172864, Compound 143::US10946023, Compound 143	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279990	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279990&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817512	378161540							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617341	FC1(F)CC(C1)Nc1nc(NC2CC(F)(F)C2)nc(n1)-c1cncc(Cl)n1	InChI=1S/C15H14ClF4N7/c16-10-6-21-5-9(24-10)11-25-12(22-7-1-14(17,18)2-7)27-13(26-11)23-8-3-15(19,20)4-8/h5-8H,1-4H2,(H2,22,23,25,26,27)	YLBDZIMKQYQWBZ-UHFFFAOYSA-N	279991	US10028961, Compound 144::US10172864, Compound 144::US10946023, Compound 144	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279991	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279991&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817496	378161541							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617343	FC(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C17H16F6N6/c18-12(19)10-2-1-3-11(26-10)13-27-14(24-8-4-16(20,21)5-8)29-15(28-13)25-9-6-17(22,23)7-9/h1-3,8-9,12H,4-7H2,(H2,24,25,27,28,29)	CMDVCIGBLUTSCG-UHFFFAOYSA-N	279992	US10028961, Compound 145::US10172864, Compound 145::US10946023, Compound 145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279992	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279992&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466129	378161542							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617344	FC(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C17H16F6N6/c18-12(19)10-2-1-3-11(26-10)13-27-14(24-8-4-16(20,21)5-8)29-15(28-13)25-9-6-17(22,23)7-9/h1-3,8-9,12H,4-7H2,(H2,24,25,27,28,29)	CMDVCIGBLUTSCG-UHFFFAOYSA-N	279992	US10028961, Compound 145::US10172864, Compound 145::US10946023, Compound 145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279992	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279992&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466129	378161542							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617346	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C17H18F7N7/c18-15(19)4-1-9(7-15)25-12-27-13(26-10-2-5-16(20,21)8-10)29-14(28-12)31-6-3-11(30-31)17(22,23)24/h3,6,9-10H,1-2,4-5,7-8H2,(H2,25,26,27,28,29)	MLJRZPLHOBYNMG-UHFFFAOYSA-N	279993	US10028961, Compound 146::US10172864, Compound 146::US10946023, Compound 146	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279993	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279993&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817473	378161543							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617347	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C17H18F7N7/c18-15(19)4-1-9(7-15)25-12-27-13(26-10-2-5-16(20,21)8-10)29-14(28-12)31-6-3-11(30-31)17(22,23)24/h3,6,9-10H,1-2,4-5,7-8H2,(H2,25,26,27,28,29)	MLJRZPLHOBYNMG-UHFFFAOYSA-N	279993	US10028961, Compound 146::US10172864, Compound 146::US10946023, Compound 146	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279993	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279993&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817473	378161543							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617349	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cncc(Cl)n1	InChI=1S/C19H22ClF4N7/c20-14-10-25-9-13(28-14)15-29-16(26-11-1-5-18(21,22)6-2-11)31-17(30-15)27-12-3-7-19(23,24)8-4-12/h9-12H,1-8H2,(H2,26,27,29,30,31)	MEWHAARPVJKYDP-UHFFFAOYSA-N	279994	US10028961, Compound 147::US10172864, Compound 147::US10946023, Compound 147	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279994	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279994&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817495	378161544							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617350	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cncc(Cl)n1	InChI=1S/C19H22ClF4N7/c20-14-10-25-9-13(28-14)15-29-16(26-11-1-5-18(21,22)6-2-11)31-17(30-15)27-12-3-7-19(23,24)8-4-12/h9-12H,1-8H2,(H2,26,27,29,30,31)	MEWHAARPVJKYDP-UHFFFAOYSA-N	279994	US10028961, Compound 147::US10172864, Compound 147::US10946023, Compound 147	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279994	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279994&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817495	378161544							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617352	FC(F)(F)c1csc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C17H17F7N6S/c18-15(19)3-1-8(5-15)25-13-28-11(12-27-10(7-31-12)17(22,23)24)29-14(30-13)26-9-2-4-16(20,21)6-9/h7-9H,1-6H2,(H2,25,26,28,29,30)	CAFOCHZZWAYFKC-UHFFFAOYSA-N	279995	US10028961, Compound 148::US10172864, Compound 148::US10946023, Compound 148	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279995	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279995&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817541	378161545							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617354	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C17H15F7N6/c18-15(19)4-8(5-15)25-13-28-12(10-2-1-3-11(27-10)17(22,23)24)29-14(30-13)26-9-6-16(20,21)7-9/h1-3,8-9H,4-7H2,(H2,25,26,28,29,30)	GJNPRCBREKXFRM-UHFFFAOYSA-N	279996	US10028961, Compound 149::US10172864, Compound 149::US10946023, Compound 149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279996	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279996&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817132	378161546							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617355	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C17H15F7N6/c18-15(19)4-8(5-15)25-13-28-12(10-2-1-3-11(27-10)17(22,23)24)29-14(30-13)26-9-6-16(20,21)7-9/h1-3,8-9H,4-7H2,(H2,25,26,28,29,30)	GJNPRCBREKXFRM-UHFFFAOYSA-N	279996	US10028961, Compound 149::US10172864, Compound 149::US10946023, Compound 149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279996	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279996&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817132	378161546							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617357	Fc1ccc2CC(Cc2c1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C23H20F6N6/c24-14-5-4-12-9-16(10-13(12)8-14)31-21-34-19(17-2-1-3-18(32-17)23(27,28)29)33-20(35-21)30-15-6-7-22(25,26)11-15/h1-5,8,15-16H,6-7,9-11H2,(H2,30,31,33,34,35)	VKNFFJYVRRTAGG-UHFFFAOYSA-N	279997	US10028961, Compound 150::US10172864, Compound 150::US10946023, Compound 150	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279997	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279997&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817109	378161547							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617359	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C23H19F5N8/c1-29-21(8-9-21)17-11-13(6-10-30-17)31-19-34-18(15-3-2-4-16(33-15)23(26,27)28)35-20(36-19)32-14-5-7-22(24,25)12-14/h2-4,6,10-11,14H,5,7-9,12H2,(H2,30,31,32,34,35,36)	LVLCYRFGYKSVJF-UHFFFAOYSA-N	279998	US10028961, Compound 151::US10172864, Compound 151	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279998	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279998&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123318205	378161548							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617360	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C23H19F5N8/c1-29-21(8-9-21)17-11-13(6-10-30-17)31-19-34-18(15-3-2-4-16(33-15)23(26,27)28)35-20(36-19)32-14-5-7-22(24,25)12-14/h2-4,6,10-11,14H,5,7-9,12H2,(H2,30,31,32,34,35,36)	LVLCYRFGYKSVJF-UHFFFAOYSA-N	279998	US10028961, Compound 151::US10172864, Compound 151	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279998	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279998&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123318205	378161548							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617362	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccccc3C2)n1	InChI=1S/C23H21F5N6/c24-22(25)9-8-15(12-22)29-20-32-19(17-6-3-7-18(31-17)23(26,27)28)33-21(34-20)30-16-10-13-4-1-2-5-14(13)11-16/h1-7,15-16H,8-12H2,(H2,29,30,32,33,34)	WFJGUJXRROVRQM-UHFFFAOYSA-N	279999	US10028961, Compound 152::US10172864, Compound 152::US10946023, Compound 152	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279999	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279999&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817119	378161549							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617363	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccccc3C2)n1	InChI=1S/C23H21F5N6/c24-22(25)9-8-15(12-22)29-20-32-19(17-6-3-7-18(31-17)23(26,27)28)33-21(34-20)30-16-10-13-4-1-2-5-14(13)11-16/h1-7,15-16H,8-12H2,(H2,29,30,32,33,34)	WFJGUJXRROVRQM-UHFFFAOYSA-N	279999	US10028961, Compound 152::US10172864, Compound 152::US10946023, Compound 152	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279999	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279999&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817119	378161549							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617365	Nc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2cc(F)cc(F)c2)n1	InChI=1S/C19H16F5N7/c20-9-5-10(21)7-12(6-9)27-18-30-16(15-13(22)1-2-14(25)28-15)29-17(31-18)26-11-3-4-19(23,24)8-11/h1-2,5-7,11H,3-4,8H2,(H2,25,28)(H2,26,27,29,30,31)	QJZUODUNLOWRRS-UHFFFAOYSA-N	280000	US10028961, Compound 153::US10172864, Compound 153::US10946023, Compound 153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280000	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280000&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799273	378161550							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617367	Fc1cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C20H13F6N7/c21-11-4-10(9-27)5-12(6-11)28-17-31-16(14-2-1-3-15(30-14)20(24,25)26)32-18(33-17)29-13-7-19(22,23)8-13/h1-6,13H,7-8H2,(H2,28,29,31,32,33)	NLDPPNGLSHUYFG-UHFFFAOYSA-N	280001	US10028961, Compound 154::US10172864, Compound 154::US10946023, Compound 154	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280001	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280001&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817126	378161551							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617369	CC(F)(F)c1nc(cs1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H20F6N6S/c1-16(19,20)13-27-11(8-31-13)12-28-14(25-9-2-4-17(21,22)6-9)30-15(29-12)26-10-3-5-18(23,24)7-10/h8-10H,2-7H2,1H3,(H2,25,26,28,29,30)	OMZLJEXLAIMEOS-UHFFFAOYSA-N	280002	US10028961, Compound 155::US10172864, Compound 155::US10946023, Compound 155	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280002	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280002&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817127	378161552							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617371	CC(Nc1nc(NC(C)C(F)(F)F)nc(n1)-c1cncc(Cl)n1)C(F)(F)F	InChI=1S/C13H12ClF6N7/c1-5(12(15,16)17)22-10-25-9(7-3-21-4-8(14)24-7)26-11(27-10)23-6(2)13(18,19)20/h3-6H,1-2H3,(H2,22,23,25,26,27)	QETWKMKQNIKDLH-UHFFFAOYSA-N	280003	US10028961, Compound 156::US10172864, Compound 156::US10946023, Compound 156	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280003	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280003&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817111	378161553							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617373	FC1(F)CCCC1Nc1nc(NC2CCCC2(F)F)nc(n1)-c1cccc(Cl)n1	InChI=1S/C18H19ClF4N6/c19-13-7-1-4-10(24-13)14-27-15(25-11-5-2-8-17(11,20)21)29-16(28-14)26-12-6-3-9-18(12,22)23/h1,4,7,11-12H,2-3,5-6,8-9H2,(H2,25,26,27,28,29)	PDSKCDIBFYQGCE-UHFFFAOYSA-N	280004	US10028961, Compound 157::US10172864, Compound 157::US10946023, Compound 157	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280004	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280004&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817134	378161554							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617375	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C20H15F8N7/c21-18(22)6-4-11(9-18)31-17-34-15(12-2-1-3-13(32-12)19(23,24)25)33-16(35-17)30-10-5-7-29-14(8-10)20(26,27)28/h1-3,5,7-8,11H,4,6,9H2,(H2,29,30,31,33,34,35)	PDXMOPYZKDLAPA-UHFFFAOYSA-N	280005	US10028961, Compound 158::US10172864, Compound 158::US10946023, Compound 158	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280005	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280005&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799020	378161555							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617377	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2nc(cs2)C(F)(F)F)c1	InChI=1S/C18H13F7N6S/c19-8-3-9(20)5-11(4-8)27-16-30-13(14-28-12(7-32-14)18(23,24)25)29-15(31-16)26-10-1-2-17(21,22)6-10/h3-5,7,10H,1-2,6H2,(H2,26,27,29,30,31)	YXCYCZLJJZKMJO-UHFFFAOYSA-N	280006	US10028961, Compound 159::US10172864, Compound 159::US10946023, Compound 159	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280006	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280006&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817493	378161556							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617379	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F7N7/c21-18(22)5-1-11(2-6-18)29-16-32-15(13-9-28-10-14(31-13)20(25,26)27)33-17(34-16)30-12-3-7-19(23,24)8-4-12/h9-12H,1-8H2,(H2,29,30,32,33,34)	SUGBJFIPDULVRS-UHFFFAOYSA-N	280007	US10028961, Compound 160::US10172864, Compound 160::US10946023, Compound 160	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280007	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280007&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817538	378161557							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617381	FC(F)(F)c1cncc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H14F7N7/c17-14(18)1-7(2-14)25-12-28-11(9-5-24-6-10(27-9)16(21,22)23)29-13(30-12)26-8-3-15(19,20)4-8/h5-8H,1-4H2,(H2,25,26,28,29,30)	BJUUMSAHTGGBTK-UHFFFAOYSA-N	280008	US10028961, Compound 161::US10172864, Compound 161::US10946023, Compound 161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280008	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280008&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817567	378161558							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617383	CC(C)(C)Nc1nc(Nc2ccnc(c2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H17F3N8/c1-18(2,3)30-17-28-15(13-5-4-6-14(26-13)19(20,21)22)27-16(29-17)25-11-7-8-24-12(9-11)10-23/h4-9H,1-3H3,(H2,24,25,27,28,29,30)	AJDWHCKBPZAYQS-UHFFFAOYSA-N	280009	US10028961, Compound 162::US10172864, Compound 162::US10946023, Compound 162	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280009	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280009&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799392	378161559							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617384	CC(C)(C)Nc1nc(Nc2ccnc(c2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H17F3N8/c1-18(2,3)30-17-28-15(13-5-4-6-14(26-13)19(20,21)22)27-16(29-17)25-11-7-8-24-12(9-11)10-23/h4-9H,1-3H3,(H2,24,25,27,28,29,30)	AJDWHCKBPZAYQS-UHFFFAOYSA-N	280009	US10028961, Compound 162::US10172864, Compound 162::US10946023, Compound 162	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280009	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280009&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799392	378161559							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617386	CC(F)(F)c1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)ccn1	InChI=1S/C21H18F7N7/c1-19(22,23)15-9-11(6-8-29-15)30-17-33-16(13-3-2-4-14(32-13)21(26,27)28)34-18(35-17)31-12-5-7-20(24,25)10-12/h2-4,6,8-9,12H,5,7,10H2,1H3,(H2,29,30,31,33,34,35)	RJZGABPOSOZJRY-UHFFFAOYSA-N	280010	US10028961, Compound 163::US10172864, Compound 163::US10946023, Compound 163	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280010	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280010&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817586	378161560							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617388	Fc1cc(Nc2nc(NC3CCC(F)(F)CC3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C22H17F6N7/c23-13-8-12(11-29)9-15(10-13)31-20-34-18(16-2-1-3-17(32-16)22(26,27)28)33-19(35-20)30-14-4-6-21(24,25)7-5-14/h1-3,8-10,14H,4-7H2,(H2,30,31,33,34,35)	RAQUPWWEGSOPEV-UHFFFAOYSA-N	280011	US10028961, Compound 164::US10172864, Compound 164::US10946023, Compound 164	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280011	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280011&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817554	378161561							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617389	Fc1cc(Nc2nc(NC3CCC(F)(F)CC3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C22H17F6N7/c23-13-8-12(11-29)9-15(10-13)31-20-34-18(16-2-1-3-17(32-16)22(26,27)28)33-19(35-20)30-14-4-6-21(24,25)7-5-14/h1-3,8-10,14H,4-7H2,(H2,30,31,33,34,35)	RAQUPWWEGSOPEV-UHFFFAOYSA-N	280011	US10028961, Compound 164::US10172864, Compound 164::US10946023, Compound 164	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280011	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280011&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817554	378161561							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617391	Nc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2cc(F)cc(F)c2)n1	InChI=1S/C20H18F5N7/c21-10-7-11(22)9-13(8-10)28-19-31-17(16-14(23)1-2-15(26)29-16)30-18(32-19)27-12-3-5-20(24,25)6-4-12/h1-2,7-9,12H,3-6H2,(H2,26,29)(H2,27,28,30,31,32)	JAYZPFRYKWCBQZ-UHFFFAOYSA-N	280012	US10028961, Compound 165::US10172864, Compound 165::US10946023, Compound 165	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280012	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280012&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799099	378161562							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617393	COc1ccc2CC(Cc2c1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C24H23F5N6O/c1-36-17-6-5-13-9-16(10-14(13)11-17)31-22-34-20(18-3-2-4-19(32-18)24(27,28)29)33-21(35-22)30-15-7-8-23(25,26)12-15/h2-6,11,15-16H,7-10,12H2,1H3,(H2,30,31,33,34,35)	KUJAJRWAMBXQRE-UHFFFAOYSA-N	280013	US10028961, Compound 166::US10172864, Compound 166::US10946023, Compound 166	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280013	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280013&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817584	378161563							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617394	C[C@@H](Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(Cl)n1)C1CC1 |r|	InChI=1S/C22H21ClN8/c1-13(14-5-6-14)26-20-29-19(16-3-2-4-18(23)28-16)30-21(31-20)27-15-7-10-25-17(11-15)22(12-24)8-9-22/h2-4,7,10-11,13-14H,5-6,8-9H2,1H3,(H2,25,26,27,29,30,31)	YPMMASFCPXGGFB-UHFFFAOYSA-N	280014	US10028961, Compound 167::US10172864, Compound 167::US10946023, Compound 167	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280014	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280014&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799158	378161564							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617395	C[C@@H](Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(Cl)n1)C1CC1 |r|	InChI=1S/C22H21ClN8/c1-13(14-5-6-14)26-20-29-19(16-3-2-4-18(23)28-16)30-21(31-20)27-15-7-10-25-17(11-15)22(12-24)8-9-22/h2-4,7,10-11,13-14H,5-6,8-9H2,1H3,(H2,25,26,27,29,30,31)	YPMMASFCPXGGFB-UHFFFAOYSA-N	280014	US10028961, Compound 167::US10172864, Compound 167::US10946023, Compound 167	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280014	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280014&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799158	378161564							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617397	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C22H17F5N8/c1-28-20(6-7-20)16-9-12(5-8-29-16)30-18-33-17(14-3-2-4-15(32-14)22(25,26)27)34-19(35-18)31-13-10-21(23,24)11-13/h2-5,8-9,13H,6-7,10-11H2,(H2,29,30,31,33,34,35)	MNROPBMECNHKDS-UHFFFAOYSA-N	280015	US10028961, Compound 168::US10172864, Compound 168	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280015	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280015&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123886256	378161565							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617399	FC(F)(F)c1ccn(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C20H16F5N9/c1-26-18(4-5-18)14-8-11(2-6-27-14)28-15-30-16(29-12-9-19(21,22)10-12)32-17(31-15)34-7-3-13(33-34)20(23,24)25/h2-3,6-8,12H,4-5,9-10H2,(H2,27,28,29,30,31,32)	BYFJDMHRGJRSCN-UHFFFAOYSA-N	280016	US10028961, Compound 169::US10172864, Compound 169	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280016	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280016&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124026281	378161566							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617401	FC(F)(F)c1nc(cs1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H13F7N6S/c16-13(17)1-6(2-13)23-11-26-9(8-5-29-10(25-8)15(20,21)22)27-12(28-11)24-7-3-14(18,19)4-7/h5-7H,1-4H2,(H2,23,24,26,27,28)	PFVOIDGYPOBGID-UHFFFAOYSA-N	280017	US10028961, Compound 170::US10172864, Compound 170::US10946023, Compound 170	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280017	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280017&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817334	378161567							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617402	FC(F)(F)c1nc(cs1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H13F7N6S/c16-13(17)1-6(2-13)23-11-26-9(8-5-29-10(25-8)15(20,21)22)27-12(28-11)24-7-3-14(18,19)4-7/h5-7H,1-4H2,(H2,23,24,26,27,28)	PFVOIDGYPOBGID-UHFFFAOYSA-N	280017	US10028961, Compound 170::US10172864, Compound 170::US10946023, Compound 170	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280017	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280017&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817334	378161567							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617404	CC(Nc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C18H12F9N7/c1-8(16(19,20)21)29-14-32-13(10-3-2-4-11(31-10)17(22,23)24)33-15(34-14)30-9-5-6-28-12(7-9)18(25,26)27/h2-8H,1H3,(H2,28,29,30,32,33,34)	RJRSWUFHCKWNQG-UHFFFAOYSA-N	280018	US10028961, Compound 171::US10172864, Compound 171::US10946023, Compound 171	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280018	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280018&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799090	378161568							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617406	FC(F)(F)c1cccc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C20H15F8N7/c21-18(22)6-4-11(9-18)31-17-34-15(12-2-1-3-13(32-12)19(23,24)25)33-16(35-17)30-10-5-7-29-14(8-10)20(26,27)28/h1-3,5,7-8,11H,4,6,9H2,(H2,29,30,31,33,34,35)	PDXMOPYZKDLAPA-UHFFFAOYSA-N	280019	US10028961, Compound 172::US10172864, Compound 172::US10946023, Compound 172	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280019	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280019&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798963	378161569							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617408	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C18H14F8N8/c19-16(20)4-1-10(8-16)29-14-30-13(28-9-2-5-27-12(7-9)18(24,25)26)31-15(32-14)34-6-3-11(33-34)17(21,22)23/h2-3,5-7,10H,1,4,8H2,(H2,27,28,29,30,31,32)	RACFSMUYWZWUMF-UHFFFAOYSA-N	280020	US10028961, Compound 173::US10172864, Compound 173::US10946023, Compound 173	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280020	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280020&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798964	378161570							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617410	FC(F)(F)c1ccn(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1 |r|	InChI=1S/C21H18F5N9/c1-27-19(6-7-19)15-10-12(3-8-28-15)29-16-31-17(30-13-2-5-20(22,23)11-13)33-18(32-16)35-9-4-14(34-35)21(24,25)26/h3-4,8-10,13H,2,5-7,11H2,(H2,28,29,30,31,32,33)	ZSYUHTUAGISLHX-UHFFFAOYSA-N	280021	US10028961, Compound 174::US10172864, Compound 174	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280021	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280021&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123271414	378161571							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617412	Fc1cc(Nc2nc(NCC3CC3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)[N+]#[C-]	InChI=1S/C20H15F4N7/c1-25-13-7-12(21)8-14(9-13)27-19-30-17(29-18(31-19)26-10-11-5-6-11)15-3-2-4-16(28-15)20(22,23)24/h2-4,7-9,11H,5-6,10H2,(H2,26,27,29,30,31)	JVFNMBJVSBMSCG-UHFFFAOYSA-N	280022	US10028961, Compound 175::US10172864, Compound 175	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280022	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280022&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123300524	378161572							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617414	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H22F7N7/c20-17(21)6-1-11(2-7-17)27-14-29-15(28-12-3-8-18(22,23)9-4-12)31-16(30-14)33-10-5-13(32-33)19(24,25)26/h5,10-12H,1-4,6-9H2,(H2,27,28,29,30,31)	SLPLEYMIEBFOSW-UHFFFAOYSA-N	280023	US10028961, Compound 176::US10172864, Compound 176::US10946023, Compound 176	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280023	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280023&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817355	378161573							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617415	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H22F7N7/c20-17(21)6-1-11(2-7-17)27-14-29-15(28-12-3-8-18(22,23)9-4-12)31-16(30-14)33-10-5-13(32-33)19(24,25)26/h5,10-12H,1-4,6-9H2,(H2,27,28,29,30,31)	SLPLEYMIEBFOSW-UHFFFAOYSA-N	280023	US10028961, Compound 176::US10172864, Compound 176::US10946023, Compound 176	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280023	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280023&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817355	378161573							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617417	CC(Nc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C16H11F9N8/c1-7(14(17,18)19)27-11-29-12(28-8-2-4-26-10(6-8)16(23,24)25)31-13(30-11)33-5-3-9(32-33)15(20,21)22/h2-7H,1H3,(H2,26,27,28,29,30,31)	ORPDRKJAHZEOLR-UHFFFAOYSA-N	280024	US10028961, Compound 177::US10172864, Compound 177::US10946023, Compound 177	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280024	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280024&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817357	378161574							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617419	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H15F8N7/c21-18(22)6-4-11(9-18)31-17-34-15(12-2-1-3-13(32-12)19(23,24)25)33-16(35-17)30-10-5-7-29-14(8-10)20(26,27)28/h1-3,5,7-8,11H,4,6,9H2,(H2,29,30,31,33,34,35)	PDXMOPYZKDLAPA-UHFFFAOYSA-N	280025	US10028961, Compound 178::US10172864, Compound 178::US10946023, Compound 178	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280025	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280025&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798985	378161575							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617420	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H15F8N7/c21-18(22)6-4-11(9-18)31-17-34-15(12-2-1-3-13(32-12)19(23,24)25)33-16(35-17)30-10-5-7-29-14(8-10)20(26,27)28/h1-3,5,7-8,11H,4,6,9H2,(H2,29,30,31,33,34,35)	PDXMOPYZKDLAPA-UHFFFAOYSA-N	280025	US10028961, Compound 178::US10172864, Compound 178::US10946023, Compound 178	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280025	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280025&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798985	378161575							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617422	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C18H14F5N9/c19-17(20)4-1-11(8-17)27-15-28-14(26-10-2-5-25-12(7-10)9-24)29-16(30-15)32-6-3-13(31-32)18(21,22)23/h2-3,5-7,11H,1,4,8H2,(H2,25,26,27,28,29,30)	LUJOXCPZQNCMMB-UHFFFAOYSA-N	280026	US10028961, Compound 179::US10172864, Compound 179::US10946023, Compound 179	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280026	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280026&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817116	378161576							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617424	CC[C@H](Nc1nc(N[C@@H](CC)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C16H17ClF6N6/c1-3-9(15(18,19)20)25-13-27-12(8-6-5-7-11(17)24-8)28-14(29-13)26-10(4-2)16(21,22)23/h5-7,9-10H,3-4H2,1-2H3,(H2,25,26,27,28,29)	SDUBFPITPDQUSW-UHFFFAOYSA-N	280027	US10028961, Compound 180::US10172864, Compound 180::US10946023, Compound 180	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280027	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280027&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817137	378161577							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617426	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C20H15F5N8/c21-19(22)6-4-12(9-19)29-18-32-16(14-2-1-3-15(30-14)20(23,24)25)31-17(33-18)28-11-5-7-27-13(8-11)10-26/h1-3,5,7-8,12H,4,6,9H2,(H2,27,28,29,31,32,33)	CPONOLJSMXHPCO-UHFFFAOYSA-N	280028	US10028961, Compound 181::US10172864, Compound 181::US10946023, Compound 181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280028	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280028&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799213	378161578							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617427	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C20H15F5N8/c21-19(22)6-4-12(9-19)29-18-32-16(14-2-1-3-15(30-14)20(23,24)25)31-17(33-18)28-11-5-7-27-13(8-11)10-26/h1-3,5,7-8,12H,4,6,9H2,(H2,27,28,29,31,32,33)	CPONOLJSMXHPCO-UHFFFAOYSA-N	280028	US10028961, Compound 181::US10172864, Compound 181::US10946023, Compound 181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280028	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280028&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799213	378161578							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617429	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccc(Cl)cc3C2)n1	InChI=1S/C23H20ClF5N6/c24-14-5-4-12-9-16(10-13(12)8-14)31-21-34-19(17-2-1-3-18(32-17)23(27,28)29)33-20(35-21)30-15-6-7-22(25,26)11-15/h1-5,8,15-16H,6-7,9-11H2,(H2,30,31,33,34,35)	XWCYRXFAEIUJMO-UHFFFAOYSA-N	280029	US10028961, Compound 182::US10172864, Compound 182::US10946023, Compound 182	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280029	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280029&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817114	378161579							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617430	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccc(Cl)cc3C2)n1	InChI=1S/C23H20ClF5N6/c24-14-5-4-12-9-16(10-13(12)8-14)31-21-34-19(17-2-1-3-18(32-17)23(27,28)29)33-20(35-21)30-15-6-7-22(25,26)11-15/h1-5,8,15-16H,6-7,9-11H2,(H2,30,31,33,34,35)	XWCYRXFAEIUJMO-UHFFFAOYSA-N	280029	US10028961, Compound 182::US10172864, Compound 182::US10946023, Compound 182	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280029	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280029&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817114	378161579							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617432	FC(F)(F)c1csc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H21F7N6S/c20-17(21)5-1-10(2-6-17)27-15-30-13(14-29-12(9-33-14)19(24,25)26)31-16(32-15)28-11-3-7-18(22,23)8-4-11/h9-11H,1-8H2,(H2,27,28,30,31,32)	AKRQSKYNRTUAQA-UHFFFAOYSA-N	280030	US10028961, Compound 183::US10172864, Compound 183::US10946023, Compound 183	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280030&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817122	378161580							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617434	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(C2)c2ccccc2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C25H25F5N6/c26-24(27)12-11-18(14-24)32-23-35-21(19-7-4-8-20(33-19)25(28,29)30)34-22(36-23)31-17-10-9-16(13-17)15-5-2-1-3-6-15/h1-8,16-18H,9-14H2,(H2,31,32,34,35,36)	VFMVBGKNWIWEDT-UHFFFAOYSA-N	280031	US10028961, Compound 184::US10172864, Compound 184::US10946023, Compound 184	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280031	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280031&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817117	378161581							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617436	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C21H18F5N9/c22-20(23)4-1-13(10-20)30-17-31-16(29-12-2-7-28-15(9-12)19(11-27)5-6-19)32-18(33-17)35-8-3-14(34-35)21(24,25)26/h2-3,7-9,13H,1,4-6,10H2,(H2,28,29,30,31,32,33)	WFGLMCWPQJGAJJ-UHFFFAOYSA-N	280032	US10028961, Compound 185::US10172864, Compound 185::US10946023, Compound 185	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280032	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280032&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799291	378161582							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617438	FC(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H23F6N7/c21-15(22)13-9-27-10-14(30-13)16-31-17(28-11-1-5-19(23,24)6-2-11)33-18(32-16)29-12-3-7-20(25,26)8-4-12/h9-12,15H,1-8H2,(H2,28,29,31,32,33)	NNVCNVORYXXOAM-UHFFFAOYSA-N	280033	US10028961, Compound 186::US10172864, Compound 186::US10946023, Compound 186	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280033	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280033&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817121	378161583							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617440	CC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C18H18F6N6/c1-16(19,20)12-4-2-3-11(27-12)13-28-14(25-9-5-17(21,22)6-9)30-15(29-13)26-10-7-18(23,24)8-10/h2-4,9-10H,5-8H2,1H3,(H2,25,26,28,29,30)	YRSZQQILDIHZRT-UHFFFAOYSA-N	280034	US10028961, Compound 187::US10172864, Compound 187::US10946023, Compound 187	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280034	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280034&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817115	378161584							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617441	CC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C18H18F6N6/c1-16(19,20)12-4-2-3-11(27-12)13-28-14(25-9-5-17(21,22)6-9)30-15(29-13)26-10-7-18(23,24)8-10/h2-4,9-10H,5-8H2,1H3,(H2,25,26,28,29,30)	YRSZQQILDIHZRT-UHFFFAOYSA-N	280034	US10028961, Compound 187::US10172864, Compound 187::US10946023, Compound 187	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280034	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280034&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817115	378161584							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617443	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3cccnc3C2)n1	InChI=1S/C22H20F5N7/c23-21(24)7-6-13(11-21)29-19-32-18(15-4-1-5-17(31-15)22(25,26)27)33-20(34-19)30-14-9-12-3-2-8-28-16(12)10-14/h1-5,8,13-14H,6-7,9-11H2,(H2,29,30,32,33,34)	UUDARVDQIIXFAL-UHFFFAOYSA-N	280035	US10028961, Compound 188::US10172864, Compound 188::US10946023, Compound 188	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280035	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280035&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817139	378161585							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617444	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C24H21F5N8/c1-30-22(10-11-22)18-13-15(7-12-31-18)33-21-36-19(16-3-2-4-17(34-16)24(27,28)29)35-20(37-21)32-14-5-8-23(25,26)9-6-14/h2-4,7,12-14H,5-6,8-11H2,(H2,31,32,33,35,36,37)	RLVMMYRYFBQTDM-UHFFFAOYSA-N	280036	US10028961, Compound 189::US10172864, Compound 189	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280036	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280036&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123396437	378161586							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617445	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C24H21F5N8/c1-30-22(10-11-22)18-13-15(7-12-31-18)33-21-36-19(16-3-2-4-17(34-16)24(27,28)29)35-20(37-21)32-14-5-8-23(25,26)9-6-14/h2-4,7,12-14H,5-6,8-11H2,(H2,31,32,33,35,36,37)	RLVMMYRYFBQTDM-UHFFFAOYSA-N	280036	US10028961, Compound 189::US10172864, Compound 189	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280036	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280036&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123396437	378161586							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617447	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C19H13F8N7/c20-17(21)7-10(8-17)30-16-33-14(11-2-1-3-12(31-11)18(22,23)24)32-15(34-16)29-9-4-5-28-13(6-9)19(25,26)27/h1-6,10H,7-8H2,(H2,28,29,30,32,33,34)	VURZKJCJGOOOFL-UHFFFAOYSA-N	280037	US10028961, Compound 190::US10172864, Compound 190::US10946023, Compound 190	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280037	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280037&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817505	378161587							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617449	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C21H21F7N6/c22-19(23)5-4-11(8-19)29-16-32-15(13-2-1-3-14(31-13)21(26,27)28)33-17(34-16)30-12-6-18(7-12)9-20(24,25)10-18/h1-3,11-12H,4-10H2,(H2,29,30,32,33,34)	RHCDZLRZYCRNDX-UHFFFAOYSA-N	280038	US10028961, Compound 191::US10172864, Compound 191::US10946023, Compound 191	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280038	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280038&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817431	378161588							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617450	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C21H21F7N6/c22-19(23)5-4-11(8-19)29-16-32-15(13-2-1-3-14(31-13)21(26,27)28)33-17(34-16)30-12-6-18(7-12)9-20(24,25)10-18/h1-3,11-12H,4-10H2,(H2,29,30,32,33,34)	RHCDZLRZYCRNDX-UHFFFAOYSA-N	280038	US10028961, Compound 191::US10172864, Compound 191::US10946023, Compound 191	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280038	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280038&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817431	378161588							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617452	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C21H17F8N7/c22-19(23)7-4-11(5-8-19)31-17-34-16(13-2-1-3-14(33-13)20(24,25)26)35-18(36-17)32-12-6-9-30-15(10-12)21(27,28)29/h1-3,6,9-11H,4-5,7-8H2,(H2,30,31,32,34,35,36)	ODBLPFGHFKRKHG-UHFFFAOYSA-N	280039	US10028961, Compound 192::US10172864, Compound 192::US10946023, Compound 192	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280039	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280039&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798913	378161589							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617453	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C21H17F8N7/c22-19(23)7-4-11(5-8-19)31-17-34-16(13-2-1-3-14(33-13)20(24,25)26)35-18(36-17)32-12-6-9-30-15(10-12)21(27,28)29/h1-3,6,9-11H,4-5,7-8H2,(H2,30,31,32,34,35,36)	ODBLPFGHFKRKHG-UHFFFAOYSA-N	280039	US10028961, Compound 192::US10172864, Compound 192::US10946023, Compound 192	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280039	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280039&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798913	378161589							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617455	C[C@@H](Nc1nc(NC(C2CC2)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C21H25F3N6/c1-11(12-5-6-12)25-19-28-18(15-3-2-4-16(26-15)21(22,23)24)29-20(30-19)27-17(13-7-8-13)14-9-10-14/h2-4,11-14,17H,5-10H2,1H3,(H2,25,27,28,29,30)	IEWNKIUGPADRRO-UHFFFAOYSA-N	280040	US10028961, Compound 193::US10172864, Compound 193::US10946023, Compound 193	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280040	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280040&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817507	378161590							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617456	C[C@@H](Nc1nc(NC(C2CC2)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C21H25F3N6/c1-11(12-5-6-12)25-19-28-18(15-3-2-4-16(26-15)21(22,23)24)29-20(30-19)27-17(13-7-8-13)14-9-10-14/h2-4,11-14,17H,5-10H2,1H3,(H2,25,27,28,29,30)	IEWNKIUGPADRRO-UHFFFAOYSA-N	280040	US10028961, Compound 193::US10172864, Compound 193::US10946023, Compound 193	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280040	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280040&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817507	378161590							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617458	FC(F)(F)c1nccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H18F7N7/c19-16(20)4-1-9(7-16)27-14-30-12(11-3-6-26-13(29-11)18(23,24)25)31-15(32-14)28-10-2-5-17(21,22)8-10/h3,6,9-10H,1-2,4-5,7-8H2,(H2,27,28,30,31,32)	VWUHSVAZJFWQPW-UHFFFAOYSA-N	280041	US10028961, Compound 194::US10172864, Compound 194::US10946023, Compound 194	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280041	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280041&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817504	378161591							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617460	Fc1cc(F)cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2nc(F)ccc2F)c1	InChI=1S/C18H12F6N6/c19-8-3-9(20)5-10(4-8)25-16-28-15(14-12(21)1-2-13(22)27-14)29-17(30-16)26-11-6-18(23,24)7-11/h1-5,11H,6-7H2,(H2,25,26,28,29,30)	YOKUNNSAZUOEON-UHFFFAOYSA-N	280042	US10028961, Compound 195::US10172864, Compound 195::US10946023, Compound 195	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280042	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280042&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798724	378161592							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617462	CC[C@@H](Nc1nc(N[C@@H](CC)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C16H17ClF6N6/c1-3-9(15(18,19)20)25-13-27-12(8-6-5-7-11(17)24-8)28-14(29-13)26-10(4-2)16(21,22)23/h5-7,9-10H,3-4H2,1-2H3,(H2,25,26,27,28,29)	SDUBFPITPDQUSW-UHFFFAOYSA-N	280043	US10028961, Compound 196::US10172864, Compound 196::US10946023, Compound 196	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280043	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280043&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817506	378161593							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617464	FC(F)(F)c1ccn(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C17H12F8N8/c18-15(19)6-9(7-15)28-13-29-12(27-8-1-3-26-11(5-8)17(23,24)25)30-14(31-13)33-4-2-10(32-33)16(20,21)22/h1-5,9H,6-7H2,(H2,26,27,28,29,30,31)	GIXRLAOMSYYYTD-UHFFFAOYSA-N	280044	US10028961, Compound 197::US10172864, Compound 197::US10946023, Compound 197	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280044	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280044&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798951	378161594							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617466	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)F)C1CC1 |r|	InChI=1S/C19H24F2N6/c1-10(12-6-7-12)22-18-25-17(15-5-3-4-14(24-15)16(20)21)26-19(27-18)23-11(2)13-8-9-13/h3-5,10-13,16H,6-9H2,1-2H3,(H2,22,23,25,26,27)	OHIIKMKNLSEDJI-UHFFFAOYSA-N	280045	US10028961, Compound 198::US10172864, Compound 198::US10946023, Compound 198	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280045	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280045&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817508	378161595							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617468	Fc1ccc(cc1)[C@@H]1C[C@@H](C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F |r,wU:9.12,7.7,(9.46,.32,;8.13,-.45,;8.13,-1.99,;6.8,-2.76,;5.46,-1.99,;5.46,-.45,;6.8,.32,;4.13,-2.76,;2.64,-2.36,;2.24,-3.85,;3.73,-4.25,;.91,-4.62,;-.43,-3.85,;-1.76,-4.62,;-3.09,-3.85,;-4.43,-4.62,;-5.76,-3.85,;-5.76,-2.31,;-7.22,-1.83,;-8.13,-3.08,;-9.46,-2.31,;-9.46,-3.85,;-7.22,-4.33,;-3.09,-2.31,;-1.76,-1.54,;-.43,-2.31,;-1.76,,;-3.09,.77,;-3.09,2.31,;-1.76,3.08,;-.43,2.31,;-.43,.77,;.91,3.08,;2.24,2.31,;.91,4.62,;2.24,3.85,)|	InChI=1S/C24H22F6N6/c25-15-6-4-13(5-7-15)14-10-17(11-14)32-22-35-20(18-2-1-3-19(33-18)24(28,29)30)34-21(36-22)31-16-8-9-23(26,27)12-16/h1-7,14,16-17H,8-12H2,(H2,31,32,34,35,36)	MVZVTAYGMMCXIJ-UHFFFAOYSA-N	280046	US10028961, Compound 199::US10172864, Compound 199::US10946023, Compound 199	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280046	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280046&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817184	378161596							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617469	Fc1ccc(cc1)[C@@H]1C[C@@H](C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F |r,wU:9.12,7.7,(9.46,.32,;8.13,-.45,;8.13,-1.99,;6.8,-2.76,;5.46,-1.99,;5.46,-.45,;6.8,.32,;4.13,-2.76,;2.64,-2.36,;2.24,-3.85,;3.73,-4.25,;.91,-4.62,;-.43,-3.85,;-1.76,-4.62,;-3.09,-3.85,;-4.43,-4.62,;-5.76,-3.85,;-5.76,-2.31,;-7.22,-1.83,;-8.13,-3.08,;-9.46,-2.31,;-9.46,-3.85,;-7.22,-4.33,;-3.09,-2.31,;-1.76,-1.54,;-.43,-2.31,;-1.76,,;-3.09,.77,;-3.09,2.31,;-1.76,3.08,;-.43,2.31,;-.43,.77,;.91,3.08,;2.24,2.31,;.91,4.62,;2.24,3.85,)|	InChI=1S/C24H22F6N6/c25-15-6-4-13(5-7-15)14-10-17(11-14)32-22-35-20(18-2-1-3-19(33-18)24(28,29)30)34-21(36-22)31-16-8-9-23(26,27)12-16/h1-7,14,16-17H,8-12H2,(H2,31,32,34,35,36)	MVZVTAYGMMCXIJ-UHFFFAOYSA-N	280046	US10028961, Compound 199::US10172864, Compound 199::US10946023, Compound 199	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280046	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280046&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817184	378161596							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617471	FC(F)(F)c1cc(Nc2nc(NCC3CC3)nc(n2)-c2cccc(Cl)n2)ccn1	InChI=1S/C18H15ClF3N7/c19-14-3-1-2-12(26-14)15-27-16(24-9-10-4-5-10)29-17(28-15)25-11-6-7-23-13(8-11)18(20,21)22/h1-3,6-8,10H,4-5,9H2,(H2,23,24,25,27,28,29)	ZMPPKTRRHWZFFR-UHFFFAOYSA-N	280047	US10028961, Compound 200::US10172864, Compound 200::US10946023, Compound 200	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280047	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280047&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798795	378161597							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617473	CC(Nc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C19H15F6N9/c1-10(18(20,21)22)28-14-30-15(29-11-3-7-27-13(9-11)17(26-2)5-6-17)32-16(31-14)34-8-4-12(33-34)19(23,24)25/h3-4,7-10H,5-6H2,1H3,(H2,27,28,29,30,31,32)	OQCGRHOQNOOHFP-UHFFFAOYSA-N	280048	US10028961, Compound 201::US10172864, Compound 201	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280048	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280048&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124000502	378161598							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617475	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)-c2ccccc2)n1	InChI=1S/C25H20F5N7/c26-24(27)11-9-17(14-24)33-23-36-21(18-7-4-8-20(34-18)25(28,29)30)35-22(37-23)32-16-10-12-31-19(13-16)15-5-2-1-3-6-15/h1-8,10,12-13,17H,9,11,14H2,(H2,31,32,33,35,36,37)	WBCWQBKLLSFRCG-UHFFFAOYSA-N	280049	US10028961, Compound 202::US10172864, Compound 202::US10946023, Compound 202	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280049	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280049&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798716	378161599							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617477	C[C@@H](Nc1nc(NC(C)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C17H18F6N6/c1-8(10-6-7-10)24-14-27-13(11-4-3-5-12(26-11)17(21,22)23)28-15(29-14)25-9(2)16(18,19)20/h3-5,8-10H,6-7H2,1-2H3,(H2,24,25,27,28,29)	AFJDSJYOWKPURG-UHFFFAOYSA-N	280050	US10028961, Compound 203::US10172864, Compound 203::US10946023, Compound 203	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280050	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280050&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817231	378161600							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617478	C[C@@H](Nc1nc(NC(C)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C17H18F6N6/c1-8(10-6-7-10)24-14-27-13(11-4-3-5-12(26-11)17(21,22)23)28-15(29-14)25-9(2)16(18,19)20/h3-5,8-10H,6-7H2,1-2H3,(H2,24,25,27,28,29)	AFJDSJYOWKPURG-UHFFFAOYSA-N	280050	US10028961, Compound 203::US10172864, Compound 203::US10946023, Compound 203	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280050	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280050&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817231	378161600							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617480	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C21H17F5N8/c22-20(23)7-4-12(5-8-20)29-18-32-17(15-2-1-3-16(31-15)21(24,25)26)33-19(34-18)30-13-6-9-28-14(10-13)11-27/h1-3,6,9-10,12H,4-5,7-8H2,(H2,28,29,30,32,33,34)	DWYLFGVHVCAESV-UHFFFAOYSA-N	280051	US10028961, Compound 204::US10172864, Compound 204::US10946023, Compound 204	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280051	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280051&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817471	378161601							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617482	FC(F)c1csc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H22F6N6S/c20-13(21)12-9-32-15(28-12)14-29-16(26-10-1-5-18(22,23)6-2-10)31-17(30-14)27-11-3-7-19(24,25)8-4-11/h9-11,13H,1-8H2,(H2,26,27,29,30,31)	KXYSDNWDMNWMPI-UHFFFAOYSA-N	280052	US10028961, Compound 205::US10172864, Compound 205::US10946023, Compound 205	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280052	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280052&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817472	378161602							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617484	CC(Cc1ccccc1)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C23H25F3N6/c1-14(13-16-7-4-3-5-8-16)27-21-30-20(18-9-6-10-19(29-18)23(24,25)26)31-22(32-21)28-15(2)17-11-12-17/h3-10,14-15,17H,11-13H2,1-2H3,(H2,27,28,30,31,32)	VUQFMBNQHKOABY-UHFFFAOYSA-N	280053	US10028961, Compound 206::US10172864, Compound 206::US10946023, Compound 206	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280053	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280053&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817468	378161603							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617485	C[C@@H](Nc1nc(Nc2ccnc(c2)C#N)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C16H11F6N9/c1-8(15(17,18)19)25-12-27-13(26-9-2-4-24-10(6-9)7-23)29-14(28-12)31-5-3-11(30-31)16(20,21)22/h2-6,8H,1H3,(H2,24,25,26,27,28,29)	WPINTHZUZYAPQF-UHFFFAOYSA-N	280054	US10028961, Compound 207::US10172864, Compound 207::US10946023, Compound 207	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280054	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280054&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817469	378161604							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617487	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(C2)c2ccccc2)nc(NC2CCC(F)(F)C2)n1 |(1.58,4.62,;1.58,3.08,;2.91,2.31,;2.91,3.85,;.24,2.31,;-1.09,3.08,;-2.43,2.31,;-2.43,.77,;-1.09,,;.24,.77,;-1.09,-1.54,;.24,-2.31,;.24,-3.85,;1.58,-4.62,;2.91,-3.85,;4.4,-4.25,;4.8,-2.76,;3.31,-2.36,;6.13,-1.99,;7.46,-2.76,;8.8,-1.99,;8.8,-.45,;7.46,.32,;6.13,-.45,;-1.09,-4.62,;-2.43,-3.85,;-3.76,-4.62,;-5.09,-3.85,;-5.09,-2.31,;-6.56,-1.83,;-7.46,-3.08,;-8.8,-2.31,;-8.8,-3.85,;-6.56,-4.33,;-2.43,-2.31,)|	InChI=1S/C24H23F5N6/c25-23(26)10-9-16(13-23)30-21-33-20(18-7-4-8-19(32-18)24(27,28)29)34-22(35-21)31-17-11-15(12-17)14-5-2-1-3-6-14/h1-8,15-17H,9-13H2,(H2,30,31,33,34,35)	FNNAHAWBMDYWEW-UHFFFAOYSA-N	280055	US10028961, Compound 208::US10172864, Compound 208::US10946023, Compound 208	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280055	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280055&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799210	378161605							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617488	CC(F)(F)c1nc(cs1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H16F6N6S/c1-14(17,18)11-25-9(6-29-11)10-26-12(23-7-2-15(19,20)3-7)28-13(27-10)24-8-4-16(21,22)5-8/h6-8H,2-5H2,1H3,(H2,23,24,26,27,28)	RGHZRMLVPJRYFM-UHFFFAOYSA-N	280056	US10028961, Compound 209::US10172864, Compound 209::US10946023, Compound 209	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280056	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280056&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817148	378161606							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617490	FC(F)(F)c1ccn(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C17H12F5N9/c18-16(19)6-11(7-16)26-14-27-13(25-9-1-3-24-10(5-9)8-23)28-15(29-14)31-4-2-12(30-31)17(20,21)22/h1-5,11H,6-7H2,(H2,24,25,26,27,28,29)	UDPIYDLIPGHOFT-UHFFFAOYSA-N	280057	US10028961, Compound 210::US10172864, Compound 210::US10946023, Compound 210	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280057	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280057&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799025	378161607							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617492	CC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C25H24F4N8/c1-23(26,27)18-4-2-3-17(34-18)20-35-21(32-15-5-8-25(28,29)9-6-15)37-22(36-20)33-16-7-12-31-19(13-16)24(14-30)10-11-24/h2-4,7,12-13,15H,5-6,8-11H2,1H3,(H2,31,32,33,35,36,37)	QRMZPBWPZWIROS-UHFFFAOYSA-N	280058	US10028961, Compound 211::US10172864, Compound 211::US10946023, Compound 211	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280058	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280058&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817159	378161608							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617494	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(Cl)n1	InChI=1S/C20H23ClF4N6/c21-15-3-1-2-14(28-15)16-29-17(26-12-4-8-19(22,23)9-5-12)31-18(30-16)27-13-6-10-20(24,25)11-7-13/h1-3,12-13H,4-11H2,(H2,26,27,29,30,31)	UIBBMCJNFUASJY-UHFFFAOYSA-N	280059	US10028961, Compound 212::US10172864, Compound 212::US10946023, Compound 212	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280059	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280059&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817149	378161609							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617496	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C19H13F5N8/c20-18(21)7-12(8-18)28-17-31-15(13-2-1-3-14(29-13)19(22,23)24)30-16(32-17)27-10-4-5-26-11(6-10)9-25/h1-6,12H,7-8H2,(H2,26,27,28,30,31,32)	RQRJJSVAJSUINU-UHFFFAOYSA-N	280060	US10028961, Compound 213::US10172864, Compound 213::US10946023, Compound 213	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280060	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280060&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817155	378161610							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617497	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C19H13F5N8/c20-18(21)7-12(8-18)28-17-31-15(13-2-1-3-14(29-13)19(22,23)24)30-16(32-17)27-10-4-5-26-11(6-10)9-25/h1-6,12H,7-8H2,(H2,26,27,28,30,31,32)	RQRJJSVAJSUINU-UHFFFAOYSA-N	280060	US10028961, Compound 213::US10172864, Compound 213::US10946023, Compound 213	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280060	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280060&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817155	378161610							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617499	CC(CC#N)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C18H20F3N7/c1-10(8-9-22)23-16-26-15(13-4-3-5-14(25-13)18(19,20)21)27-17(28-16)24-11(2)12-6-7-12/h3-5,10-12H,6-8H2,1-2H3,(H2,23,24,26,27,28)	IFMDZJNJPFFCSK-UHFFFAOYSA-N	280061	US10028961, Compound 214::US10172864, Compound 214::US10946023, Compound 214	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280061	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280061&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799309	378161611							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617500	CC(CC#N)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C18H20F3N7/c1-10(8-9-22)23-16-26-15(13-4-3-5-14(25-13)18(19,20)21)27-17(28-16)24-11(2)12-6-7-12/h3-5,10-12H,6-8H2,1-2H3,(H2,23,24,26,27,28)	IFMDZJNJPFFCSK-UHFFFAOYSA-N	280061	US10028961, Compound 214::US10172864, Compound 214::US10946023, Compound 214	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280061	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280061&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799309	378161611							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617502	FC(F)(F)CNc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-c1cccc(Cl)n1	InChI=1S/C19H14ClF3N8/c1-24-18(6-7-18)13-9-11(5-8-25-13)27-17-30-15(12-3-2-4-14(20)28-12)29-16(31-17)26-10-19(21,22)23/h2-5,8-9H,6-7,10H2,(H2,25,26,27,29,30,31)	RJYPNTZBJZUSPV-UHFFFAOYSA-N	280062	US10028961, Compound 215::US10172864, Compound 215	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280062	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280062&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124015477	378161612							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617504	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC(F)(F)C2)nc(NCC2CC(F)(F)C2)n1	InChI=1S/C19H19F7N6/c20-17(21)4-10(5-17)8-27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-9-11-6-18(22,23)7-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	OSLHWFZOOADJCB-UHFFFAOYSA-N	280063	US10028961, Compound 216::US10172864, Compound 216::US10946023, Compound 216	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280063	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280063&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817178	378161613							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617506	CC(Nc1nc(Nc2ccnc(c2)-c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C23H17F6N7/c1-13(22(24,25)26)31-20-34-19(16-8-5-9-18(33-16)23(27,28)29)35-21(36-20)32-15-10-11-30-17(12-15)14-6-3-2-4-7-14/h2-13H,1H3,(H2,30,31,32,34,35,36)	NWTISIXHXPIMSM-UHFFFAOYSA-N	280064	US10028961, Compound 217::US10172864, Compound 217::US10946023, Compound 217	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280064	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280064&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817152	378161614							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617508	CC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C22H26F6N6/c1-20(23,24)16-4-2-3-15(31-16)17-32-18(29-13-5-9-21(25,26)10-6-13)34-19(33-17)30-14-7-11-22(27,28)12-8-14/h2-4,13-14H,5-12H2,1H3,(H2,29,30,32,33,34)	NAVGNOHPZVGLBF-UHFFFAOYSA-N	280065	US10028961, Compound 218::US10172864, Compound 218::US10946023, Compound 218	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280065	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280065&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817160	378161615							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617510	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)c2ccccc2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C24H24F5N7/c25-23(26)11-9-15(13-23)30-21-33-20(18-7-4-8-19(32-18)24(27,28)29)34-22(35-21)31-16-10-12-36(14-16)17-5-2-1-3-6-17/h1-8,15-16H,9-14H2,(H2,30,31,33,34,35)	ATYUYZMINSFJHA-UHFFFAOYSA-N	280066	US10028961, Compound 219::US10172864, Compound 219::US10946023, Compound 219	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280066	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280066&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817049	378161616							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617511	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)-c2ccccc2)n1	InChI=1S/C26H22F5N7/c27-25(28)12-9-17(10-13-25)33-23-36-22(19-7-4-8-21(35-19)26(29,30)31)37-24(38-23)34-18-11-14-32-20(15-18)16-5-2-1-3-6-16/h1-8,11,14-15,17H,9-10,12-13H2,(H2,32,33,34,36,37,38)	WTQROKONFNCZLX-UHFFFAOYSA-N	280067	US10028961, Compound 220::US10172864, Compound 220::US10946023, Compound 220	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280067	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280067&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798796	378161617							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617513	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H15F8N7/c21-18(22)7-10(8-18)9-30-16-33-15(12-2-1-3-13(32-12)19(23,24)25)34-17(35-16)31-11-4-5-29-14(6-11)20(26,27)28/h1-6,10H,7-9H2,(H2,29,30,31,33,34,35)	OWAVUCAENWNGFB-UHFFFAOYSA-N	280068	US10028961, Compound 221::US10172864, Compound 221::US10946023, Compound 221	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280068	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280068&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799308	378161618							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617515	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)c2ccccn2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C23H23F5N8/c24-22(25)9-7-14(12-22)30-20-33-19(16-4-3-5-17(32-16)23(26,27)28)34-21(35-20)31-15-8-11-36(13-15)18-6-1-2-10-29-18/h1-6,10,14-15H,7-9,11-13H2,(H2,30,31,33,34,35)	TYLCUGJKUXBFOZ-UHFFFAOYSA-N	280069	US10028961, Compound 222::US10172864, Compound 222::US10946023, Compound 222	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280069	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280069&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817038	378161619							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617516	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)c2ccccn2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C23H23F5N8/c24-22(25)9-7-14(12-22)30-20-33-19(16-4-3-5-17(32-16)23(26,27)28)34-21(35-20)31-15-8-11-36(13-15)18-6-1-2-10-29-18/h1-6,10,14-15H,7-9,11-13H2,(H2,30,31,33,34,35)	TYLCUGJKUXBFOZ-UHFFFAOYSA-N	280069	US10028961, Compound 222::US10172864, Compound 222::US10946023, Compound 222	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280069	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280069&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817038	378161619							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617518	FC(F)(F)c1nc(cs1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H21F7N6S/c20-17(21)5-1-10(2-6-17)27-15-30-13(12-9-33-14(29-12)19(24,25)26)31-16(32-15)28-11-3-7-18(22,23)8-4-11/h9-11H,1-8H2,(H2,27,28,30,31,32)	PFTFOLWIPCINKJ-UHFFFAOYSA-N	280070	US10028961, Compound 223::US10172864, Compound 223::US10946023, Compound 223	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280070	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280070&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817026	378161620							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617519	FC(F)(F)c1nc(cs1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H21F7N6S/c20-17(21)5-1-10(2-6-17)27-15-30-13(12-9-33-14(29-12)19(24,25)26)31-16(32-15)28-11-3-7-18(22,23)8-4-11/h9-11H,1-8H2,(H2,27,28,30,31,32)	PFTFOLWIPCINKJ-UHFFFAOYSA-N	280070	US10028961, Compound 223::US10172864, Compound 223::US10946023, Compound 223	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280070	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280070&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817026	378161620							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617521	FC(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H24F6N6/c22-16(23)14-2-1-3-15(30-14)17-31-18(28-12-4-8-20(24,25)9-5-12)33-19(32-17)29-13-6-10-21(26,27)11-7-13/h1-3,12-13,16H,4-11H2,(H2,28,29,31,32,33)	VPZNRBLRTQODKB-UHFFFAOYSA-N	280071	US10028961, Compound 224::US10172864, Compound 224::US10946023, Compound 224	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280071	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280071&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817029	378161621							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617522	FC(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H24F6N6/c22-16(23)14-2-1-3-15(30-14)17-31-18(28-12-4-8-20(24,25)9-5-12)33-19(32-17)29-13-6-10-21(26,27)11-7-13/h1-3,12-13,16H,4-11H2,(H2,28,29,31,32,33)	VPZNRBLRTQODKB-UHFFFAOYSA-N	280071	US10028961, Compound 224::US10172864, Compound 224::US10946023, Compound 224	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280071	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280071&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817029	378161621							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617524	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccc(Br)cc3C2)n1	InChI=1S/C23H20BrF5N6/c24-14-5-4-12-9-16(10-13(12)8-14)31-21-34-19(17-2-1-3-18(32-17)23(27,28)29)33-20(35-21)30-15-6-7-22(25,26)11-15/h1-5,8,15-16H,6-7,9-11H2,(H2,30,31,33,34,35)	VVBVABDTGIHRLF-UHFFFAOYSA-N	280072	US10028961, Compound 225::US10172864, Compound 225::US10946023, Compound 225	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280072	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280072&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817025	378161622							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617525	FC(F)(F)CNc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H14F6N8/c1-27-18(6-7-18)14-9-11(5-8-28-14)30-17-33-15(32-16(34-17)29-10-19(21,22)23)12-3-2-4-13(31-12)20(24,25)26/h2-5,8-9H,6-7,10H2,(H2,28,29,30,32,33,34)	PFZLERVPZNDZDD-UHFFFAOYSA-N	280073	US10028961, Compound 226::US10172864, Compound 226	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280073	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280073&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123942898	378161623							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617526	FC(F)(F)CNc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H14F6N8/c1-27-18(6-7-18)14-9-11(5-8-28-14)30-17-33-15(32-16(34-17)29-10-19(21,22)23)12-3-2-4-13(31-12)20(24,25)26/h2-5,8-9H,6-7,10H2,(H2,28,29,30,32,33,34)	PFZLERVPZNDZDD-UHFFFAOYSA-N	280073	US10028961, Compound 226::US10172864, Compound 226	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280073	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280073&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123942898	378161623							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617528	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)c2ncccn2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C22H22F5N9/c23-21(24)7-5-13(11-21)30-18-33-17(15-3-1-4-16(32-15)22(25,26)27)34-19(35-18)31-14-6-10-36(12-14)20-28-8-2-9-29-20/h1-4,8-9,13-14H,5-7,10-12H2,(H2,30,31,33,34,35)	YPXQHURHYKDPKF-UHFFFAOYSA-N	280074	US10028961, Compound 227::US10172864, Compound 227::US10946023, Compound 227	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280074	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280074&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817030	378161624							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617529	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)c2ncccn2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C22H22F5N9/c23-21(24)7-5-13(11-21)30-18-33-17(15-3-1-4-16(32-15)22(25,26)27)34-19(35-18)31-14-6-10-36(12-14)20-28-8-2-9-29-20/h1-4,8-9,13-14H,5-7,10-12H2,(H2,30,31,33,34,35)	YPXQHURHYKDPKF-UHFFFAOYSA-N	280074	US10028961, Compound 227::US10172864, Compound 227::US10946023, Compound 227	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280074	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280074&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817030	378161624							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617531	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C22H23F7N6/c23-20(24)6-4-12(5-7-20)30-17-33-16(14-2-1-3-15(32-14)22(27,28)29)34-18(35-17)31-13-8-19(9-13)10-21(25,26)11-19/h1-3,12-13H,4-11H2,(H2,30,31,33,34,35)	MBSONQUQQPPYRL-UHFFFAOYSA-N	280075	US10028961, Compound 228::US10172864, Compound 228::US10946023, Compound 228	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280075	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280075&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817032	378161625							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617533	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C25H21F5N8/c1-31-23(6-7-23)18-9-14(5-8-32-18)33-20-36-19(16-3-2-4-17(35-16)25(28,29)30)37-21(38-20)34-15-10-22(11-15)12-24(26,27)13-22/h2-5,8-9,15H,6-7,10-13H2,(H2,32,33,34,36,37,38)	QOYBVQHDVXHECC-UHFFFAOYSA-N	280076	US10028961, Compound 229::US10172864, Compound 229	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280076	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280076&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123245946	378161626							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617534	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C25H21F5N8/c1-31-23(6-7-23)18-9-14(5-8-32-18)33-20-36-19(16-3-2-4-17(35-16)25(28,29)30)37-21(38-20)34-15-10-22(11-15)12-24(26,27)13-22/h2-5,8-9,15H,6-7,10-13H2,(H2,32,33,34,36,37,38)	QOYBVQHDVXHECC-UHFFFAOYSA-N	280076	US10028961, Compound 229::US10172864, Compound 229	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280076	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280076&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123245946	378161626							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617536	Fc1ccc(cc1)[C@H]1C[C@@H](C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F |r,wU:7.7,wD:9.12,(9.46,.32,;8.13,-.45,;8.13,-1.99,;6.8,-2.76,;5.46,-1.99,;5.46,-.45,;6.8,.32,;4.13,-2.76,;3.73,-4.25,;2.24,-3.85,;2.64,-2.36,;.91,-4.62,;-.43,-3.85,;-1.76,-4.62,;-3.09,-3.85,;-4.43,-4.62,;-5.76,-3.85,;-5.76,-2.31,;-7.22,-1.83,;-8.13,-3.08,;-9.46,-2.31,;-9.46,-3.85,;-7.22,-4.33,;-3.09,-2.31,;-1.76,-1.54,;-.43,-2.31,;-1.76,,;-3.09,.77,;-3.09,2.31,;-1.76,3.08,;-.43,2.31,;-.43,.77,;.91,3.08,;2.24,2.31,;.91,4.62,;2.24,3.85,)|	InChI=1S/C24H22F6N6/c25-15-6-4-13(5-7-15)14-10-17(11-14)32-22-35-20(18-2-1-3-19(33-18)24(28,29)30)34-21(36-22)31-16-8-9-23(26,27)12-16/h1-7,14,16-17H,8-12H2,(H2,31,32,34,35,36)	MVZVTAYGMMCXIJ-UHFFFAOYSA-N	280077	US10028961, Compound 230::US10172864, Compound 230::US10946023, Compound 230	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280077	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280077&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817184	378161627							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617538	CC(C)(CC#N)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C21H19F5N8/c1-19(2,8-9-27)34-18-32-16(13-5-4-6-14(30-13)21(24,25)26)31-17(33-18)29-12-7-10-28-15(11-12)20(3,22)23/h4-7,10-11H,8H2,1-3H3,(H2,28,29,31,32,33,34)	BFTBMPMZGISYIU-UHFFFAOYSA-N	280078	US10028961, Compound 231::US10172864, Compound 231::US10946023, Compound 231	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280078	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280078&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117800590	378161628							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617539	CC(C)(CC#N)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C21H19F5N8/c1-19(2,8-9-27)34-18-32-16(13-5-4-6-14(30-13)21(24,25)26)31-17(33-18)29-12-7-10-28-15(11-12)20(3,22)23/h4-7,10-11H,8H2,1-3H3,(H2,28,29,31,32,33,34)	BFTBMPMZGISYIU-UHFFFAOYSA-N	280078	US10028961, Compound 231::US10172864, Compound 231::US10946023, Compound 231	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280078	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280078&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117800590	378161628							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617541	FC(F)(F)CNc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C17H10F9N7/c18-15(19,20)7-28-13-31-12(9-2-1-3-10(30-9)16(21,22)23)32-14(33-13)29-8-4-5-27-11(6-8)17(24,25)26/h1-6H,7H2,(H2,27,28,29,31,32,33)	PLCJHAPDBYLXRZ-UHFFFAOYSA-N	280079	US10028961, Compound 232::US10172864, Compound 232::US10946023, Compound 232	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280079	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280079&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817637	378161629							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617543	COCCC(C)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C19H25F3N6O/c1-11(9-10-29-3)23-17-26-16(14-5-4-6-15(25-14)19(20,21)22)27-18(28-17)24-12(2)13-7-8-13/h4-6,11-13H,7-10H2,1-3H3,(H2,23,24,26,27,28)	VFXTUCQMLFRPEW-UHFFFAOYSA-N	280080	US10028961, Compound 233::US10172864, Compound 233::US10946023, Compound 233	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280080	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280080&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817167	378161630							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617544	C[C@@H](Nc1nc(NC2C3CC4CC(C3)CC2C4)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r,wU:1.0,TLB:6:7:9:12.11.13,THB:14:15:9:12.11.13,14:12:9:7.15.16,11:12:7:9.10.16,(-4.39,-1.54,;-4.39,-3.08,;-3.05,-3.85,;-1.72,-3.08,;-.38,-3.85,;.95,-3.08,;2.28,-3.85,;3.62,-3.08,;4.95,-3.85,;6.28,-3.08,;6.28,-1.54,;7.26,-.81,;5.72,-.81,;4.95,-2.6,;4.55,.03,;3.62,-1.54,;4.95,-.77,;.95,-1.54,;-.38,-.77,;-1.72,-1.54,;-.38,.77,;-1.72,1.54,;-1.72,3.08,;-.38,3.85,;1,3.11,;.95,1.54,;2.33,3.88,;3.66,4.65,;3.1,2.54,;1.56,5.21,;-5.72,-3.85,;-7.26,-3.85,;-6.49,-5.18,)|			280081	US10028961, Compound 234::US10172864, Compound 234::US10946023, Compound 234	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280081	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280081&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			122440897	378161631							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617545	CC(C)(O)CNc1nc(Nc2cc(F)cc(F)c2)nc(n1)-n1ccc(n1)C(F)(F)F	InChI=1S/C17H16F5N7O/c1-16(2,30)8-23-13-25-14(24-11-6-9(18)5-10(19)7-11)27-15(26-13)29-4-3-12(28-29)17(20,21)22/h3-7,30H,8H2,1-2H3,(H2,23,24,25,26,27)	WNTKHAXLAGBPKP-UHFFFAOYSA-N	280082	US10028961, Compound 235::US10172864, Compound 235::US10946023, Compound 235	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280082	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280082&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799168	378161632							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617547	CC(C)(O)CNc1nc(Nc2cc(F)cc(Cl)c2)nc(n1)-c1cccc(n1)C(C)(F)F	InChI=1S/C20H20ClF3N6O/c1-19(2,31)10-25-17-28-16(14-5-4-6-15(27-14)20(3,23)24)29-18(30-17)26-13-8-11(21)7-12(22)9-13/h4-9,31H,10H2,1-3H3,(H2,25,26,28,29,30)	OCYNITMCPHUSLK-UHFFFAOYSA-N	280083	US10028961, Compound 236::US10172864, Compound 236::US10946023, Compound 236	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280083	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280083&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817133	378161633							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617549	FC(F)(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H18F7N7/c19-16(20)4-1-9(7-16)27-14-30-13(12-26-6-3-11(29-12)18(23,24)25)31-15(32-14)28-10-2-5-17(21,22)8-10/h3,6,9-10H,1-2,4-5,7-8H2,(H2,27,28,30,31,32)	KWUXKJRKEMYSCZ-UHFFFAOYSA-N	280084	US10028961, Compound 237::US10172864, Compound 237::US10946023, Compound 237	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280084	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280084&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817165	378161634							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617550	FC(F)(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H18F7N7/c19-16(20)4-1-9(7-16)27-14-30-13(12-26-6-3-11(29-12)18(23,24)25)31-15(32-14)28-10-2-5-17(21,22)8-10/h3,6,9-10H,1-2,4-5,7-8H2,(H2,27,28,30,31,32)	KWUXKJRKEMYSCZ-UHFFFAOYSA-N	280084	US10028961, Compound 237::US10172864, Compound 237::US10946023, Compound 237	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280084	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280084&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817165	378161634							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617552	FC(F)(F)c1cccc(n1)-c1nc(NC2CN(C2)c2ccccn2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C22H21F5N8/c23-21(24)8-7-13(10-21)29-19-32-18(15-4-3-5-16(31-15)22(25,26)27)33-20(34-19)30-14-11-35(12-14)17-6-1-2-9-28-17/h1-6,9,13-14H,7-8,10-12H2,(H2,29,30,32,33,34)	ZBGLZSWJEQJJBZ-UHFFFAOYSA-N	280085	US10028961, Compound 238::US10172864, Compound 238::US10946023, Compound 238	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280085	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280085&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817186	378161635							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617553	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(N[C@@H]2CN(C(=O)C2)c2ccccn2)n1 |r|	InChI=1S/C23H21F5N8O/c24-22(25)8-7-13(11-22)30-20-33-19(15-4-3-5-16(32-15)23(26,27)28)34-21(35-20)31-14-10-18(37)36(12-14)17-6-1-2-9-29-17/h1-6,9,13-14H,7-8,10-12H2,(H2,30,31,33,34,35)	JXQUUPVCXHTUAY-UHFFFAOYSA-N	280086	US10028961, Compound 239::US10172864, Compound 239::US10946023, Compound 239	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280086	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280086&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817437	378161636							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617554	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(C=C)n1)C1CC1 |r|	InChI=1S/C20H26N6/c1-4-16-6-5-7-17(23-16)18-24-19(21-12(2)14-8-9-14)26-20(25-18)22-13(3)15-10-11-15/h4-7,12-15H,1,8-11H2,2-3H3,(H2,21,22,24,25,26)	OYMZLJQIWORYFQ-UHFFFAOYSA-N	280087	US10028961, Compound 240::US10172864, Compound 240::US10946023, Compound 240	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280087	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280087&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466127	378161637							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617555	CC(C)OCC(C)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C20H27F3N6O/c1-11(2)30-10-12(3)24-18-27-17(15-6-5-7-16(26-15)20(21,22)23)28-19(29-18)25-13(4)14-8-9-14/h5-7,11-14H,8-10H2,1-4H3,(H2,24,25,27,28,29)	HNZFJEZPGBZOCO-UHFFFAOYSA-N	280088	US10028961, Compound 241::US10172864, Compound 241::US10946023, Compound 241	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280088	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280088&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817568	378161638							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617556	CC(C)OCC(C)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C20H27F3N6O/c1-11(2)30-10-12(3)24-18-27-17(15-6-5-7-16(26-15)20(21,22)23)28-19(29-18)25-13(4)14-8-9-14/h5-7,11-14H,8-10H2,1-4H3,(H2,24,25,27,28,29)	HNZFJEZPGBZOCO-UHFFFAOYSA-N	280088	US10028961, Compound 241::US10172864, Compound 241::US10946023, Compound 241	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280088	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280088&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817568	378161638							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617557	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccc(cc3C2)C#N)n1	InChI=1S/C24H20F5N7/c25-23(26)7-6-16(11-23)31-21-34-20(18-2-1-3-19(33-18)24(27,28)29)35-22(36-21)32-17-9-14-5-4-13(12-30)8-15(14)10-17/h1-5,8,16-17H,6-7,9-11H2,(H2,31,32,34,35,36)	TXAOJZZVXLZXJJ-UHFFFAOYSA-N	280089	US10028961, Compound 242::US10172864, Compound 242::US10946023, Compound 242	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280089	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280089&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817436	378161639							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617558	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccc(cc3C2)C#N)n1	InChI=1S/C24H20F5N7/c25-23(26)7-6-16(11-23)31-21-34-20(18-2-1-3-19(33-18)24(27,28)29)35-22(36-21)32-17-9-14-5-4-13(12-30)8-15(14)10-17/h1-5,8,16-17H,6-7,9-11H2,(H2,31,32,34,35,36)	TXAOJZZVXLZXJJ-UHFFFAOYSA-N	280089	US10028961, Compound 242::US10172864, Compound 242::US10946023, Compound 242	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280089	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280089&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817436	378161639							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617559	FC(F)(F)c1cccc(n1)-c1nc(NC2CN(C2)c2cccnc2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C22H21F5N8/c23-21(24)7-6-13(9-21)29-19-32-18(16-4-1-5-17(31-16)22(25,26)27)33-20(34-19)30-14-11-35(12-14)15-3-2-8-28-10-15/h1-5,8,10,13-14H,6-7,9,11-12H2,(H2,29,30,32,33,34)	MOFOELJBPOCBKQ-UHFFFAOYSA-N	280090	US10028961, Compound 243::US10172864, Compound 243::US10946023, Compound 243	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280090	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280090&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817396	378161640							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617560	CC(C)(O)CNc1nc(Nc2cc(F)cc(c2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H17F4N7O/c1-19(2,32)10-26-17-29-16(14-4-3-5-15(28-14)20(22,23)24)30-18(31-17)27-13-7-11(9-25)6-12(21)8-13/h3-8,32H,10H2,1-2H3,(H2,26,27,29,30,31)	MVCBBRZTMZDXPK-UHFFFAOYSA-N	280091	US10028961, Compound 244::US10172864, Compound 244::US10946023, Compound 244	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280091	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280091&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798806	378161641							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617561	CC(C)(O)CNc1nc(Nc2cc(F)cc(c2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H17F4N7O/c1-19(2,32)10-26-17-29-16(14-4-3-5-15(28-14)20(22,23)24)30-18(31-17)27-13-7-11(9-25)6-12(21)8-13/h3-8,32H,10H2,1-2H3,(H2,26,27,29,30,31)	MVCBBRZTMZDXPK-UHFFFAOYSA-N	280091	US10028961, Compound 244::US10172864, Compound 244::US10946023, Compound 244	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280091	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280091&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798806	378161641							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617563	CC(C)(C)Nc1nc(Nc2cc(F)cc(c2)C#N)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C19H16F4N8/c1-18(2,3)31-17-29-15(14-25-5-4-13(27-14)19(21,22)23)28-16(30-17)26-12-7-10(9-24)6-11(20)8-12/h4-8H,1-3H3,(H2,26,28,29,30,31)	TWTMGQUEQUWIKR-UHFFFAOYSA-N	280092	US10028961, Compound 245::US10172864, Compound 245::US10946023, Compound 245	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280092	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280092&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817542	378161642							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617564	CC(C)(C)Nc1nc(Nc2cc(F)cc(c2)C#N)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C19H16F4N8/c1-18(2,3)31-17-29-15(14-25-5-4-13(27-14)19(21,22)23)28-16(30-17)26-12-7-10(9-24)6-11(20)8-12/h4-8H,1-3H3,(H2,26,28,29,30,31)	TWTMGQUEQUWIKR-UHFFFAOYSA-N	280092	US10028961, Compound 245::US10172864, Compound 245::US10946023, Compound 245	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280092	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280092&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817542	378161642							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617566	C[C@@H](Nc1nc(NCCOc2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C22H23F3N6O/c1-14(15-10-11-15)27-21-30-19(17-8-5-9-18(28-17)22(23,24)25)29-20(31-21)26-12-13-32-16-6-3-2-4-7-16/h2-9,14-15H,10-13H2,1H3,(H2,26,27,29,30,31)	YVNVAIVKELSNHE-UHFFFAOYSA-N	280093	US10028961, Compound 246::US10172864, Compound 246::US10946023, Compound 246	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280093	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280093&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817294	378161643							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617567	C[C@@H](Nc1nc(NCCOc2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C22H23F3N6O/c1-14(15-10-11-15)27-21-30-19(17-8-5-9-18(28-17)22(23,24)25)29-20(31-21)26-12-13-32-16-6-3-2-4-7-16/h2-9,14-15H,10-13H2,1H3,(H2,26,27,29,30,31)	YVNVAIVKELSNHE-UHFFFAOYSA-N	280093	US10028961, Compound 246::US10172864, Compound 246::US10946023, Compound 246	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280093	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280093&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817294	378161643							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617569	CC(C)(Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C20H17F5N8/c1-18(2,10-26)33-17-31-15(12-5-4-6-13(29-12)20(23,24)25)30-16(32-17)28-11-7-8-27-14(9-11)19(3,21)22/h4-9H,1-3H3,(H2,27,28,30,31,32,33)	BDJHMJRZDMMMSY-UHFFFAOYSA-N	280094	US10028961, Compound 247::US10172864, Compound 247::US10946023, Compound 247	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280094	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280094&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799111	378161644							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617570	CC(C)(Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C20H17F5N8/c1-18(2,10-26)33-17-31-15(12-5-4-6-13(29-12)20(23,24)25)30-16(32-17)28-11-7-8-27-14(9-11)19(3,21)22/h4-9H,1-3H3,(H2,27,28,30,31,32,33)	BDJHMJRZDMMMSY-UHFFFAOYSA-N	280094	US10028961, Compound 247::US10172864, Compound 247::US10946023, Compound 247	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280094	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280094&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799111	378161644							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617572	CC(C)(O)CNc1nc(Nc2cccc(Cl)c2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H18ClF3N6O/c1-18(2,30)10-24-16-27-15(13-7-4-8-14(26-13)19(21,22)23)28-17(29-16)25-12-6-3-5-11(20)9-12/h3-9,30H,10H2,1-2H3,(H2,24,25,27,28,29)	NRKSVSMTVTZXKR-UHFFFAOYSA-N	280095	US10028961, Compound 248::US10172864, Compound 248::US10946023, Compound 248	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280095	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280095&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817492	378161645							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617573	CC(C)(O)CNc1nc(Nc2cccc(Cl)c2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H18ClF3N6O/c1-18(2,30)10-24-16-27-15(13-7-4-8-14(26-13)19(21,22)23)28-17(29-16)25-12-6-3-5-11(20)9-12/h3-9,30H,10H2,1-2H3,(H2,24,25,27,28,29)	NRKSVSMTVTZXKR-UHFFFAOYSA-N	280095	US10028961, Compound 248::US10172864, Compound 248::US10946023, Compound 248	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280095	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280095&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817492	378161645							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617575	Nc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H24F5N7/c21-13-1-2-14(26)29-15(13)16-30-17(27-11-3-7-19(22,23)8-4-11)32-18(31-16)28-12-5-9-20(24,25)10-6-12/h1-2,11-12H,3-10H2,(H2,26,29)(H2,27,28,30,31,32)	AHCWVZUQCYWTLX-UHFFFAOYSA-N	280096	US10028961, Compound 249::US10172864, Compound 249::US10946023, Compound 249	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280096	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280096&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799328	378161646							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617577	CC(CC#N)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H17F5N8/c1-11(6-8-26)28-17-31-16(13-4-3-5-14(30-13)20(23,24)25)32-18(33-17)29-12-7-9-27-15(10-12)19(2,21)22/h3-5,7,9-11H,6H2,1-2H3,(H2,27,28,29,31,32,33)	KFKFZAMDAKZTOH-UHFFFAOYSA-N	280097	US10028961, Compound 250::US10172864, Compound 250::US10946023, Compound 250	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280097	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280097&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117800753	378161647							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617578	CC(CC#N)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H17F5N8/c1-11(6-8-26)28-17-31-16(13-4-3-5-14(30-13)20(23,24)25)32-18(33-17)29-12-7-9-27-15(10-12)19(2,21)22/h3-5,7,9-11H,6H2,1-2H3,(H2,27,28,29,31,32,33)	KFKFZAMDAKZTOH-UHFFFAOYSA-N	280097	US10028961, Compound 250::US10172864, Compound 250::US10946023, Compound 250	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280097	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280097&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117800753	378161647							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617580	FC(F)(F)c1nccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H14F7N7/c17-14(18)3-7(4-14)25-12-28-10(9-1-2-24-11(27-9)16(21,22)23)29-13(30-12)26-8-5-15(19,20)6-8/h1-2,7-8H,3-6H2,(H2,25,26,28,29,30)	YXRZGIVPZUGDBI-UHFFFAOYSA-N	280098	US10028961, Compound 251::US10172864, Compound 251::US10946023, Compound 251	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280098	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280098&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817045	378161648							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617582	FC(F)(F)Oc1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C19H19F7N6O/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)33-19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	MQELCCGCZSQGHW-UHFFFAOYSA-N	280099	US10028961, Compound 252::US10172864, Compound 252::US10946023, Compound 252	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280099	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280099&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817037	378161649							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617583	FC(F)(F)Oc1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C19H19F7N6O/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)33-19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	MQELCCGCZSQGHW-UHFFFAOYSA-N	280099	US10028961, Compound 252::US10172864, Compound 252::US10946023, Compound 252	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280099	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280099&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817037	378161649							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617585	CC(Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C19H15F5N8/c1-10(9-25)27-16-30-15(12-4-3-5-13(29-12)19(22,23)24)31-17(32-16)28-11-6-7-26-14(8-11)18(2,20)21/h3-8,10H,1-2H3,(H2,26,27,28,30,31,32)	DOYNKYWVGHFSIP-UHFFFAOYSA-N	280100	US10028961, Compound 253::US10172864, Compound 253::US10946023, Compound 253	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280100	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280100&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799196	378161650							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617586	CC(Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C19H15F5N8/c1-10(9-25)27-16-30-15(12-4-3-5-13(29-12)19(22,23)24)31-17(32-16)28-11-6-7-26-14(8-11)18(2,20)21/h3-8,10H,1-2H3,(H2,26,27,28,30,31,32)	DOYNKYWVGHFSIP-UHFFFAOYSA-N	280100	US10028961, Compound 253::US10172864, Compound 253::US10946023, Compound 253	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280100	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280100&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799196	378161650							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617588	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3cc(Br)cc(Br)c3C2)n1	InChI=1S/C23H19Br2F5N6/c24-12-6-11-7-14(9-15(11)16(25)8-12)32-21-35-19(17-2-1-3-18(33-17)23(28,29)30)34-20(36-21)31-13-4-5-22(26,27)10-13/h1-3,6,8,13-14H,4-5,7,9-10H2,(H2,31,32,34,35,36)	OLURZMKGUXLJTI-UHFFFAOYSA-N	280101	US10028961, Compound 254::US10172864, Compound 254::US10946023, Compound 254	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280101	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280101&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817035	378161651							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617589	FC(F)(F)c1cccc(n1)-c1nc(NC2CCOCC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H23F5N6O/c21-19(22)8-4-12(5-9-19)26-17-29-16(14-2-1-3-15(28-14)20(23,24)25)30-18(31-17)27-13-6-10-32-11-7-13/h1-3,12-13H,4-11H2,(H2,26,27,29,30,31)	XOGJBAWBFBEDJT-UHFFFAOYSA-N	280102	US10028961, Compound 255::US10172864, Compound 255::US10946023, Compound 255	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280102	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280102&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817036	378161652							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617590	FC(F)(F)c1cccc(n1)-c1nc(NC2CCOCC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H23F5N6O/c21-19(22)8-4-12(5-9-19)26-17-29-16(14-2-1-3-15(28-14)20(23,24)25)30-18(31-17)27-13-6-10-32-11-7-13/h1-3,12-13H,4-11H2,(H2,26,27,29,30,31)	XOGJBAWBFBEDJT-UHFFFAOYSA-N	280102	US10028961, Compound 255::US10172864, Compound 255::US10946023, Compound 255	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280102	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280102&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817036	378161652							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617591	FC(F)(F)c1ccnc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H14F7N7/c17-14(18)3-7(4-14)25-12-28-11(10-24-2-1-9(27-10)16(21,22)23)29-13(30-12)26-8-5-15(19,20)6-8/h1-2,7-8H,3-6H2,(H2,25,26,28,29,30)	FPHDGFLOXFTVGJ-UHFFFAOYSA-N	280103	US10028961, Compound 256::US10172864, Compound 256::US10946023, Compound 256	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280103	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280103&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817034	378161653							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617592	FC(F)(F)c1ccnc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H14F7N7/c17-14(18)3-7(4-14)25-12-28-11(10-24-2-1-9(27-10)16(21,22)23)29-13(30-12)26-8-5-15(19,20)6-8/h1-2,7-8H,3-6H2,(H2,25,26,28,29,30)	FPHDGFLOXFTVGJ-UHFFFAOYSA-N	280103	US10028961, Compound 256::US10172864, Compound 256::US10946023, Compound 256	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280103	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280103&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817034	378161653							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617594	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C22H17F8N7/c23-20(24)9-19(10-20)7-12(8-19)33-18-36-16(13-2-1-3-14(34-13)21(25,26)27)35-17(37-18)32-11-4-5-31-15(6-11)22(28,29)30/h1-6,12H,7-10H2,(H2,31,32,33,35,36,37)	BTPLBROFKCBOEI-UHFFFAOYSA-N	280104	US10028961, Compound 257::US10172864, Compound 257::US10946023, Compound 257	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280104	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280104&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799484	378161654							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617595	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C22H17F8N7/c23-20(24)9-19(10-20)7-12(8-19)33-18-36-16(13-2-1-3-14(34-13)21(25,26)27)35-17(37-18)32-11-4-5-31-15(6-11)22(28,29)30/h1-6,12H,7-10H2,(H2,31,32,33,35,36,37)	BTPLBROFKCBOEI-UHFFFAOYSA-N	280104	US10028961, Compound 257::US10172864, Compound 257::US10946023, Compound 257	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280104	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280104&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799484	378161654							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617597	FC1(F)CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C1CC1	InChI=1S/C21H24F4N6/c22-20(23)8-6-13(10-20)26-18-29-17(16-3-1-2-15(28-16)12-4-5-12)30-19(31-18)27-14-7-9-21(24,25)11-14/h1-3,12-14H,4-11H2,(H2,26,27,29,30,31)	KKFMWMMEDKZDHR-UHFFFAOYSA-N	280105	US10028961, Compound 258::US10172864, Compound 258::US10946023, Compound 258	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280105	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280105&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817039	378161655							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617598	CC(C)(O)CNc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C22H21F3N8O/c1-20(2,34)12-28-18-31-17(14-4-3-5-15(30-14)22(23,24)25)32-19(33-18)29-13-6-9-27-16(10-13)21(11-26)7-8-21/h3-6,9-10,34H,7-8,12H2,1-2H3,(H2,27,28,29,31,32,33)	VVOQXSMDMBLJHJ-UHFFFAOYSA-N	280106	US10028961, Compound 259::US10172864, Compound 259::US10946023, Compound 259	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280106	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280106&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798959	378161656							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617600	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)CC3)nc(n2)-c2nc(F)ccc2F)c1	InChI=1S/C20H16F6N6/c21-10-7-11(22)9-13(8-10)28-19-31-17(16-14(23)1-2-15(24)29-16)30-18(32-19)27-12-3-5-20(25,26)6-4-12/h1-2,7-9,12H,3-6H2,(H2,27,28,30,31,32)	KQPYGTOTVLIIEB-UHFFFAOYSA-N	280107	US10028961, Compound 260::US10172864, Compound 260::US10946023, Compound 260	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280107	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280107&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817161	378161657							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617601	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)CC3)nc(n2)-c2nc(F)ccc2F)c1	InChI=1S/C20H16F6N6/c21-10-7-11(22)9-13(8-10)28-19-31-17(16-14(23)1-2-15(24)29-16)30-18(32-19)27-12-3-5-20(25,26)6-4-12/h1-2,7-9,12H,3-6H2,(H2,27,28,30,31,32)	KQPYGTOTVLIIEB-UHFFFAOYSA-N	280107	US10028961, Compound 260::US10172864, Compound 260::US10946023, Compound 260	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280107	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280107&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817161	378161657							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617603	FC(F)(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C22H18F5N9/c23-21(24)4-1-13(10-21)32-19-35-17(16-30-8-3-14(33-16)22(25,26)27)34-18(36-19)31-12-2-7-29-15(9-12)20(11-28)5-6-20/h2-3,7-9,13H,1,4-6,10H2,(H2,29,31,32,34,35,36)	NQLUCGNQWCNNAV-UHFFFAOYSA-N	280108	US10028961, Compound 261::US10172864, Compound 261::US10946023, Compound 261	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280108	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280108&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799322	378161658							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617604	FC(F)(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C22H18F5N9/c23-21(24)4-1-13(10-21)32-19-35-17(16-30-8-3-14(33-16)22(25,26)27)34-18(36-19)31-12-2-7-29-15(9-12)20(11-28)5-6-20/h2-3,7-9,13H,1,4-6,10H2,(H2,29,31,32,34,35,36)	NQLUCGNQWCNNAV-UHFFFAOYSA-N	280108	US10028961, Compound 261::US10172864, Compound 261::US10946023, Compound 261	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280108	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280108&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799322	378161658							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617606	C[C@@H](Nc1nc(NCC(C)(C)C#N)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C19H22F3N7/c1-11(12-7-8-12)25-17-28-15(13-5-4-6-14(26-13)19(20,21)22)27-16(29-17)24-10-18(2,3)9-23/h4-6,11-12H,7-8,10H2,1-3H3,(H2,24,25,27,28,29)	YMYMOIAVHSSRHV-UHFFFAOYSA-N	280109	US10028961, Compound 262::US10172864, Compound 262::US10946023, Compound 262	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280109	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280109&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817189	378161659							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617607	C[C@@H](Nc1nc(NCC(C)(C)C#N)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C19H22F3N7/c1-11(12-7-8-12)25-17-28-15(13-5-4-6-14(26-13)19(20,21)22)27-16(29-17)24-10-18(2,3)9-23/h4-6,11-12H,7-8,10H2,1-3H3,(H2,24,25,27,28,29)	YMYMOIAVHSSRHV-UHFFFAOYSA-N	280109	US10028961, Compound 262::US10172864, Compound 262::US10946023, Compound 262	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280109	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280109&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817189	378161659							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617608	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)C(=O)c2ccccc2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C25H24F5N7O/c26-24(27)11-9-16(13-24)31-22-34-20(18-7-4-8-19(33-18)25(28,29)30)35-23(36-22)32-17-10-12-37(14-17)21(38)15-5-2-1-3-6-15/h1-8,16-17H,9-14H2,(H2,31,32,34,35,36)	IGICKZPCOKPPMZ-UHFFFAOYSA-N	280110	US10028961, Compound 263::US10172864, Compound 263::US10946023, Compound 263	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280110	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280110&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817170	378161660							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617609	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)C(=O)c2ccccc2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C25H24F5N7O/c26-24(27)11-9-16(13-24)31-22-34-20(18-7-4-8-19(33-18)25(28,29)30)35-23(36-22)32-17-10-12-37(14-17)21(38)15-5-2-1-3-6-15/h1-8,16-17H,9-14H2,(H2,31,32,34,35,36)	IGICKZPCOKPPMZ-UHFFFAOYSA-N	280110	US10028961, Compound 263::US10172864, Compound 263::US10946023, Compound 263	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280110	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280110&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817170	378161660							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617610	CC(C)(O)CNc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C18H21F5N6O/c1-16(2,30)9-24-14-27-13(11-4-3-5-12(26-11)18(21,22)23)28-15(29-14)25-10-6-7-17(19,20)8-10/h3-5,10,30H,6-9H2,1-2H3,(H2,24,25,27,28,29)	BBXPSOCEABWQQG-UHFFFAOYSA-N	280111	US10028961, Compound 264::US10172864, Compound 264::US10946023, Compound 264	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280111	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280111&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817169	378161661							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617611	FC1(F)CC2(CC(C2)Nc2nc(NC3CC4(C3)CC(F)(F)C4)nc(n2)-c2cccc(Cl)n2)C1	InChI=1S/C22H23ClF4N6/c23-15-3-1-2-14(30-15)16-31-17(28-12-4-19(5-12)8-21(24,25)9-19)33-18(32-16)29-13-6-20(7-13)10-22(26,27)11-20/h1-3,12-13H,4-11H2,(H2,28,29,31,32,33)	PBFHHOMGSNGWEC-UHFFFAOYSA-N	280112	US10028961, Compound 265::US10172864, Compound 265::US10946023, Compound 265	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280112	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280112&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817162	378161662							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617612	FC1(F)CC2(CC(C2)Nc2nc(NC3CC4(C3)CC(F)(F)C4)nc(n2)-c2cccc(Cl)n2)C1	InChI=1S/C22H23ClF4N6/c23-15-3-1-2-14(30-15)16-31-17(28-12-4-19(5-12)8-21(24,25)9-19)33-18(32-16)29-13-6-20(7-13)10-22(26,27)11-20/h1-3,12-13H,4-11H2,(H2,28,29,31,32,33)	PBFHHOMGSNGWEC-UHFFFAOYSA-N	280112	US10028961, Compound 265::US10172864, Compound 265::US10946023, Compound 265	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280112	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280112&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817162	378161662							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617613	CS(=O)(=O)N1CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C21H26F5N7O2S/c1-36(34,35)33-11-7-14(8-12-33)28-19-31-17(15-3-2-4-16(29-15)21(24,25)26)30-18(32-19)27-13-5-9-20(22,23)10-6-13/h2-4,13-14H,5-12H2,1H3,(H2,27,28,30,31,32)	XMCNRFYMKPJZQG-UHFFFAOYSA-N	280113	US10028961, Compound 266::US10172864, Compound 266::US10946023, Compound 266	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280113	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280113&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817164	378161663							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617614	CS(=O)(=O)N1CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C21H26F5N7O2S/c1-36(34,35)33-11-7-14(8-12-33)28-19-31-17(15-3-2-4-16(29-15)21(24,25)26)30-18(32-19)27-13-5-9-20(22,23)10-6-13/h2-4,13-14H,5-12H2,1H3,(H2,27,28,30,31,32)	XMCNRFYMKPJZQG-UHFFFAOYSA-N	280113	US10028961, Compound 266::US10172864, Compound 266::US10946023, Compound 266	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280113	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280113&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817164	378161663							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617615	CC(C)(CNc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C21H19F5N8/c1-19(2,10-27)11-29-17-32-16(13-5-4-6-14(31-13)21(24,25)26)33-18(34-17)30-12-7-8-28-15(9-12)20(3,22)23/h4-9H,11H2,1-3H3,(H2,28,29,30,32,33,34)	LWUOICMGVABMMB-UHFFFAOYSA-N	280114	US10028961, Compound 267::US10172864, Compound 267::US10946023, Compound 267	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280114	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280114&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117800203	378161664							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617616	CC(C)(CNc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C21H19F5N8/c1-19(2,10-27)11-29-17-32-16(13-5-4-6-14(31-13)21(24,25)26)33-18(34-17)30-12-7-8-28-15(9-12)20(3,22)23/h4-9H,11H2,1-3H3,(H2,28,29,30,32,33,34)	LWUOICMGVABMMB-UHFFFAOYSA-N	280114	US10028961, Compound 267::US10172864, Compound 267::US10946023, Compound 267	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280114	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280114&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117800203	378161664							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617618	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1nccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C18H22F3N7/c1-9(11-3-4-11)23-16-26-15(14-22-8-7-13(25-14)18(19,20)21)27-17(28-16)24-10(2)12-5-6-12/h7-12H,3-6H2,1-2H3,(H2,23,24,26,27,28)	DDVPWDBXRXZEBC-UHFFFAOYSA-N	280115	US10028961, Compound 268::US10172864, Compound 268::US10946023, Compound 268	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280115	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280115&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817172	378161665							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617619	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1nccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C18H22F3N7/c1-9(11-3-4-11)23-16-26-15(14-22-8-7-13(25-14)18(19,20)21)27-17(28-16)24-10(2)12-5-6-12/h7-12H,3-6H2,1-2H3,(H2,23,24,26,27,28)	DDVPWDBXRXZEBC-UHFFFAOYSA-N	280115	US10028961, Compound 268::US10172864, Compound 268::US10946023, Compound 268	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280115	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280115&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817172	378161665							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617621	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C#N)C1CC1 |r|	InChI=1S/C19H23N7/c1-11(13-6-7-13)21-18-24-17(16-5-3-4-15(10-20)23-16)25-19(26-18)22-12(2)14-8-9-14/h3-5,11-14H,6-9H2,1-2H3,(H2,21,22,24,25,26)	BOOMYPYTFNGPNE-UHFFFAOYSA-N	280116	US10028961, Compound 269::US10172864, Compound 269::US10946023, Compound 269	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280116	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280116&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466128	378161666							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617622	FC(F)(F)c1nccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F7N7/c21-18(22)6-1-11(2-7-18)29-16-32-14(13-5-10-28-15(31-13)20(25,26)27)33-17(34-16)30-12-3-8-19(23,24)9-4-12/h5,10-12H,1-4,6-9H2,(H2,29,30,32,33,34)	VFDBHGHEXPAMBP-UHFFFAOYSA-N	280117	US10028961, Compound 270::US10172864, Compound 270::US10946023, Compound 270	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280117	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280117&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817589	378161667							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617623	FC(F)(F)c1nccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F7N7/c21-18(22)6-1-11(2-7-18)29-16-32-14(13-5-10-28-15(31-13)20(25,26)27)33-17(34-16)30-12-3-8-19(23,24)9-4-12/h5,10-12H,1-4,6-9H2,(H2,29,30,32,33,34)	VFDBHGHEXPAMBP-UHFFFAOYSA-N	280117	US10028961, Compound 270::US10172864, Compound 270::US10946023, Compound 270	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280117	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280117&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817589	378161667							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617625	CC(CC#N)Nc1nc(NC(C)C[N+]#[C-])nc(n1)-c1cccc(Cl)n1	InChI=1S/C16H17ClN8/c1-10(7-8-18)20-15-23-14(12-5-4-6-13(17)22-12)24-16(25-15)21-11(2)9-19-3/h4-6,10-11H,7,9H2,1-2H3,(H2,20,21,23,24,25)	DPKMJIDGQOHGGQ-UHFFFAOYSA-N	280118	US10028961, Compound 271::US10172864, Compound 271	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280118	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280118&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124023000	378161668							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617626	CC(CC#N)Nc1nc(NC(C)C[N+]#[C-])nc(n1)-c1cccc(Cl)n1	InChI=1S/C16H17ClN8/c1-10(7-8-18)20-15-23-14(12-5-4-6-13(17)22-12)24-16(25-15)21-11(2)9-19-3/h4-6,10-11H,7,9H2,1-2H3,(H2,20,21,23,24,25)	DPKMJIDGQOHGGQ-UHFFFAOYSA-N	280118	US10028961, Compound 271::US10172864, Compound 271	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280118	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280118&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124023000	378161668							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617627	Fc1ccc(cc1)[C@@H]1C[C@@H](C1)Nc1nc(N[C@H]2C[C@H](C2)c2ccc(F)cc2)nc(n1)-c1cccc(n1)C(F)(F)F |r,wU:16.17,9.12,18.22,7.7,(11.22,.32,;9.89,-.45,;9.89,-1.99,;8.55,-2.76,;7.22,-1.99,;7.22,-.45,;8.55,.32,;5.89,-2.76,;4.4,-2.36,;4,-3.85,;5.49,-4.25,;2.67,-4.62,;1.33,-3.85,;,-4.62,;-1.33,-3.85,;-2.67,-4.62,;-4,-3.85,;-5.49,-4.25,;-5.89,-2.76,;-4.4,-2.36,;-7.22,-1.99,;-7.22,-.45,;-8.55,.32,;-9.89,-.45,;-11.22,.32,;-9.89,-1.99,;-8.55,-2.76,;-1.33,-2.31,;,-1.54,;1.33,-2.31,;;-1.33,.77,;-1.33,2.31,;,3.08,;1.33,2.31,;1.33,.77,;2.67,3.08,;2.67,4.62,;4,2.31,;4,3.85,)|	InChI=1S/C29H25F5N6/c30-20-8-4-16(5-9-20)18-12-22(13-18)35-27-38-26(24-2-1-3-25(37-24)29(32,33)34)39-28(40-27)36-23-14-19(15-23)17-6-10-21(31)11-7-17/h1-11,18-19,22-23H,12-15H2,(H2,35,36,38,39,40)	NMLSZZYWTRQLTB-UHFFFAOYSA-N	280119	US10028961, Compound 272::US10172864, Compound 272::US10946023, Compound 272	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280119	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280119&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817318	378161669							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617628	Fc1ccc(cc1)[C@@H]1C[C@@H](C1)Nc1nc(N[C@H]2C[C@H](C2)c2ccc(F)cc2)nc(n1)-c1cccc(n1)C(F)(F)F |r,wU:16.17,9.12,18.22,7.7,(11.22,.32,;9.89,-.45,;9.89,-1.99,;8.55,-2.76,;7.22,-1.99,;7.22,-.45,;8.55,.32,;5.89,-2.76,;4.4,-2.36,;4,-3.85,;5.49,-4.25,;2.67,-4.62,;1.33,-3.85,;,-4.62,;-1.33,-3.85,;-2.67,-4.62,;-4,-3.85,;-5.49,-4.25,;-5.89,-2.76,;-4.4,-2.36,;-7.22,-1.99,;-7.22,-.45,;-8.55,.32,;-9.89,-.45,;-11.22,.32,;-9.89,-1.99,;-8.55,-2.76,;-1.33,-2.31,;,-1.54,;1.33,-2.31,;;-1.33,.77,;-1.33,2.31,;,3.08,;1.33,2.31,;1.33,.77,;2.67,3.08,;2.67,4.62,;4,2.31,;4,3.85,)|	InChI=1S/C29H25F5N6/c30-20-8-4-16(5-9-20)18-12-22(13-18)35-27-38-26(24-2-1-3-25(37-24)29(32,33)34)39-28(40-27)36-23-14-19(15-23)17-6-10-21(31)11-7-17/h1-11,18-19,22-23H,12-15H2,(H2,35,36,38,39,40)	NMLSZZYWTRQLTB-UHFFFAOYSA-N	280119	US10028961, Compound 272::US10172864, Compound 272::US10946023, Compound 272	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280119	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280119&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817318	378161669							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617630	CC(=O)N1CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C22H26F5N7O/c1-13(35)34-11-7-15(8-12-34)29-20-32-18(16-3-2-4-17(30-16)22(25,26)27)31-19(33-20)28-14-5-9-21(23,24)10-6-14/h2-4,14-15H,5-12H2,1H3,(H2,28,29,31,32,33)	PVZIUYNREPTYEJ-UHFFFAOYSA-N	280120	US10028961, Compound 273::US10172864, Compound 273::US10946023, Compound 273	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280120	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280120&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817549	378161670							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617631	CC(=O)N1CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C22H26F5N7O/c1-13(35)34-11-7-15(8-12-34)29-20-32-18(16-3-2-4-17(30-16)22(25,26)27)31-19(33-20)28-14-5-9-21(23,24)10-6-14/h2-4,14-15H,5-12H2,1H3,(H2,28,29,31,32,33)	PVZIUYNREPTYEJ-UHFFFAOYSA-N	280120	US10028961, Compound 273::US10172864, Compound 273::US10946023, Compound 273	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280120	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280120&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817549	378161670							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617632	CC(C)(C)OC(=O)N1CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C25H32F5N7O2/c1-23(2,3)39-22(38)37-13-9-16(10-14-37)32-21-35-19(17-5-4-6-18(33-17)25(28,29)30)34-20(36-21)31-15-7-11-24(26,27)12-8-15/h4-6,15-16H,7-14H2,1-3H3,(H2,31,32,34,35,36)	MMAPFCIIBGUZQG-UHFFFAOYSA-N	280121	US10028961, Compound 274::US10172864, Compound 274::US10946023, Compound 274	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280121	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280121&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817557	378161671							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617633	CC(C)(C)OC(=O)N1CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C25H32F5N7O2/c1-23(2,3)39-22(38)37-13-9-16(10-14-37)32-21-35-19(17-5-4-6-18(33-17)25(28,29)30)34-20(36-21)31-15-7-11-24(26,27)12-8-15/h4-6,15-16H,7-14H2,1-3H3,(H2,31,32,34,35,36)	MMAPFCIIBGUZQG-UHFFFAOYSA-N	280121	US10028961, Compound 274::US10172864, Compound 274::US10946023, Compound 274	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280121	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280121&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817557	378161671							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617634	Cn1cc(c(n1)C(F)(F)F)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H24F7N7/c1-34-10-13(14(33-34)20(25,26)27)15-30-16(28-11-2-6-18(21,22)7-3-11)32-17(31-15)29-12-4-8-19(23,24)9-5-12/h10-12H,2-9H2,1H3,(H2,28,29,30,31,32)	MZFAUIFIADPAFR-UHFFFAOYSA-N	280122	US10028961, Compound 275::US10172864, Compound 275::US10946023, Compound 275	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280122	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280122&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817548	378161672							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617635	Fc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F6N6/c21-13-1-2-14(22)29-15(13)16-30-17(27-11-3-7-19(23,24)8-4-11)32-18(31-16)28-12-5-9-20(25,26)10-6-12/h1-2,11-12H,3-10H2,(H2,27,28,30,31,32)	PKVKJUWOHXPGCE-UHFFFAOYSA-N	280123	US10028961, Compound 276::US10172864, Compound 276::US10946023, Compound 276	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280123	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280123&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799150	378161673							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617636	Fc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F6N6/c21-13-1-2-14(22)29-15(13)16-30-17(27-11-3-7-19(23,24)8-4-11)32-18(31-16)28-12-5-9-20(25,26)10-6-12/h1-2,11-12H,3-10H2,(H2,27,28,30,31,32)	PKVKJUWOHXPGCE-UHFFFAOYSA-N	280123	US10028961, Compound 276::US10172864, Compound 276::US10946023, Compound 276	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280123	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280123&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799150	378161673							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617637	FC(F)(F)Oc1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C17H15F7N6O/c18-15(19)4-8(5-15)25-13-28-12(10-2-1-3-11(27-10)31-17(22,23)24)29-14(30-13)26-9-6-16(20,21)7-9/h1-3,8-9H,4-7H2,(H2,25,26,28,29,30)	KBOZWPPHVTYNOC-UHFFFAOYSA-N	280124	US10028961, Compound 277::US10172864, Compound 277::US10946023, Compound 277	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280124	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280124&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817028	378161674							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617639	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cncc(Cl)c1)C1CC1 |r|	InChI=1S/C18H23ClN6/c1-10(12-3-4-12)21-17-23-16(14-7-15(19)9-20-8-14)24-18(25-17)22-11(2)13-5-6-13/h7-13H,3-6H2,1-2H3,(H2,21,22,23,24,25)	KKRJUHWKVGWXTJ-UHFFFAOYSA-N	280125	US10028961, Compound 278::US10172864, Compound 278::US10946023, Compound 278	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280125	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280125&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817585	378161675							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617641	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-n1cc(I)cn1)C1CC1 |r|	InChI=1S/C16H22IN7/c1-9(11-3-4-11)19-14-21-15(20-10(2)12-5-6-12)23-16(22-14)24-8-13(17)7-18-24/h7-12H,3-6H2,1-2H3,(H2,19,20,21,22,23)	XKHRDUPMIXLGTD-UHFFFAOYSA-N	280126	US10028961, Compound 279::US10172864, Compound 279::US10946023, Compound 279	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280126	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280126&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817477	378161676							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617642	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-n1cc(I)cn1)C1CC1 |r|	InChI=1S/C16H22IN7/c1-9(11-3-4-11)19-14-21-15(20-10(2)12-5-6-12)23-16(22-14)24-8-13(17)7-18-24/h7-12H,3-6H2,1-2H3,(H2,19,20,21,22,23)	XKHRDUPMIXLGTD-UHFFFAOYSA-N	280126	US10028961, Compound 279::US10172864, Compound 279::US10946023, Compound 279	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280126	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280126&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817477	378161676							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617644	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(Cc3ccccc3)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C25H26F5N7/c26-24(27)11-9-17(13-24)31-22-34-21(19-7-4-8-20(33-19)25(28,29)30)35-23(36-22)32-18-10-12-37(15-18)14-16-5-2-1-3-6-16/h1-8,17-18H,9-15H2,(H2,31,32,34,35,36)	UWVLIFBOSBPFON-UHFFFAOYSA-N	280127	US10028961, Compound 280::US10172864, Compound 280::US10946023, Compound 280	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280127	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280127&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817414	378161677							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617645	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(Cc3ccccc3)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C25H26F5N7/c26-24(27)11-9-17(13-24)31-22-34-21(19-7-4-8-20(33-19)25(28,29)30)35-23(36-22)32-18-10-12-37(15-18)14-16-5-2-1-3-6-16/h1-8,17-18H,9-15H2,(H2,31,32,34,35,36)	UWVLIFBOSBPFON-UHFFFAOYSA-N	280127	US10028961, Compound 280::US10172864, Compound 280::US10946023, Compound 280	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280127	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280127&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817414	378161677							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617646	C[C@H](CO)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C17H21F3N6O/c1-9(8-27)21-15-24-14(12-4-3-5-13(23-12)17(18,19)20)25-16(26-15)22-10(2)11-6-7-11/h3-5,9-11,27H,6-8H2,1-2H3,(H2,21,22,24,25,26)	RFBMTEMJWRNYFW-UHFFFAOYSA-N	280128	US10028961, Compound 281::US10172864, Compound 281::US10946023, Compound 281	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280128	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280128&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817475	378161678							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617647	Cc1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H26F4N6/c1-13-3-2-4-16(26-13)17-29-18(27-14-5-9-20(22,23)10-6-14)31-19(30-17)28-15-7-11-21(24,25)12-8-15/h2-4,14-15H,5-12H2,1H3,(H2,27,28,29,30,31)	YBYIINHMDQHRAL-UHFFFAOYSA-N	280129	US10028961, Compound 282::US10172864, Compound 282::US10946023, Compound 282	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280129	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280129&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817481	378161679							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617648	CC(F)(F)c1nc(cs1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H24F6N6S/c1-18(21,22)15-29-13(10-33-15)14-30-16(27-11-2-6-19(23,24)7-3-11)32-17(31-14)28-12-4-8-20(25,26)9-5-12/h10-12H,2-9H2,1H3,(H2,27,28,30,31,32)	BCVWBQGSHAGBJM-UHFFFAOYSA-N	280130	US10028961, Compound 283::US10172864, Compound 283::US10946023, Compound 283	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280130	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280130&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817484	378161680							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617650	C[C@@H](Nc1nc(NCC#C)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C17H17F3N6/c1-3-9-21-15-24-14(12-5-4-6-13(23-12)17(18,19)20)25-16(26-15)22-10(2)11-7-8-11/h1,4-6,10-11H,7-9H2,2H3,(H2,21,22,24,25,26)	NAAKTSUJFNNEGV-UHFFFAOYSA-N	280131	US10028961, Compound 284::US10172864, Compound 284::US10946023, Compound 284	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280131	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280131&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817478	378161681							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617651	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(N)n1)C1CC1 |r|	InChI=1S/C18H25N7/c1-10(12-6-7-12)20-17-23-16(14-4-3-5-15(19)22-14)24-18(25-17)21-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,19,22)(H2,20,21,23,24,25)	PRARPIBZHWEZPY-UHFFFAOYSA-N	280132	US10028961, Compound 285::US10172864, Compound 285::US10946023, Compound 285	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280132	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280132&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817474	378161682							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617653	COC(=O)CCNc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C18H21F3N6O2/c1-10(11-6-7-11)23-17-26-15(12-4-3-5-13(24-12)18(19,20)21)25-16(27-17)22-9-8-14(28)29-2/h3-5,10-11H,6-9H2,1-2H3,(H2,22,23,25,26,27)	KELFRTMXGNRFFX-UHFFFAOYSA-N	280133	US10028961, Compound 286::US10172864, Compound 286::US10946023, Compound 286	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280133	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280133&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817479	378161683							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617654	CC(C)(O)CNc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H23F5N6O/c1-17(2,31)10-25-15-28-14(12-4-3-5-13(27-12)19(22,23)24)29-16(30-15)26-11-6-8-18(20,21)9-7-11/h3-5,11,31H,6-10H2,1-2H3,(H2,25,26,28,29,30)	IWJRYKAPBRKGLL-UHFFFAOYSA-N	280134	US10028961, Compound 287::US10172864, Compound 287::US10946023, Compound 287	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280134	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280134&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817444	378161684							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617656	CC(C)(O)CNc1nc(Nc2ccnc(c2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H17F3N8O/c1-18(2,31)10-25-16-28-15(13-4-3-5-14(27-13)19(20,21)22)29-17(30-16)26-11-6-7-24-12(8-11)9-23/h3-8,31H,10H2,1-2H3,(H2,24,25,26,28,29,30)	VHJMSJJKVRIIBP-UHFFFAOYSA-N	280135	US10028961, Compound 288::US10172864, Compound 288	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280135	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280135&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799170	378161685							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617658	CC(C)(C)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C19H19F5N8/c1-17(2,3)32-16-30-14(13-26-8-6-11(28-13)19(22,23)24)29-15(31-16)27-10-5-7-25-12(9-10)18(4,20)21/h5-9H,1-4H3,(H2,25,27,29,30,31,32)	VVDJVXUCSQFDNF-UHFFFAOYSA-N	280136	US10028961, Compound 289::US10172864, Compound 289::US10946023, Compound 289	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280136	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280136&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817459	378161686							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617659	CC(C)(C)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C19H19F5N8/c1-17(2,3)32-16-30-14(13-26-8-6-11(28-13)19(22,23)24)29-15(31-16)27-10-5-7-25-12(9-10)18(4,20)21/h5-9H,1-4H3,(H2,25,27,29,30,31,32)	VVDJVXUCSQFDNF-UHFFFAOYSA-N	280136	US10028961, Compound 289::US10172864, Compound 289::US10946023, Compound 289	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280136	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280136&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817459	378161686							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617661	OC1CCCC1Nc1nc(NC2CCCC2O)nc(n1)-c1cccc(Cl)n1	InChI=1S/C18H23ClN6O2/c19-15-9-3-6-12(20-15)16-23-17(21-10-4-1-7-13(10)26)25-18(24-16)22-11-5-2-8-14(11)27/h3,6,9-11,13-14,26-27H,1-2,4-5,7-8H2,(H2,21,22,23,24,25)	FIFASAIIXLNWSD-UHFFFAOYSA-N	280137	US10028961, Compound 290::US10172864, Compound 290::US10946023, Compound 290	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280137	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280137&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817457	378161687							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617662	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2cc3ccccc3[nH]2)n1	InChI=1S/C22H18F5N7/c23-21(24)9-8-13(11-21)28-19-32-18(15-6-3-7-16(29-15)22(25,26)27)33-20(34-19)31-17-10-12-4-1-2-5-14(12)30-17/h1-7,10,13,30H,8-9,11H2,(H2,28,31,32,33,34)	JUXFFUXEYZBADD-UHFFFAOYSA-N	280138	US10028961, Compound 291::US10172864, Compound 291::US10946023, Compound 291	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280138	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280138&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817461	378161688							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617663	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cc(F)ccc1F)C1CC1 |r|	InChI=1S/C19H23F2N5/c1-10(12-3-4-12)22-18-24-17(15-9-14(20)7-8-16(15)21)25-19(26-18)23-11(2)13-5-6-13/h7-13H,3-6H2,1-2H3,(H2,22,23,24,25,26)	OFWGSSJSAWQKRK-UHFFFAOYSA-N	280139	US10028961, Compound 292::US10172864, Compound 292::US10946023, Compound 292	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280139	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280139&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817456	378161689							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617664	FC(F)(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F7N7/c21-18(22)6-1-11(2-7-18)29-16-32-15(14-28-10-5-13(31-14)20(25,26)27)33-17(34-16)30-12-3-8-19(23,24)9-4-12/h5,10-12H,1-4,6-9H2,(H2,29,30,32,33,34)	MDCZNBIZILVZSF-UHFFFAOYSA-N	280140	US10028961, Compound 293::US10172864, Compound 293::US10946023, Compound 293	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280140	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280140&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817463	378161690							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617665	FC(F)(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F7N7/c21-18(22)6-1-11(2-7-18)29-16-32-15(14-28-10-5-13(31-14)20(25,26)27)33-17(34-16)30-12-3-8-19(23,24)9-4-12/h5,10-12H,1-4,6-9H2,(H2,29,30,32,33,34)	MDCZNBIZILVZSF-UHFFFAOYSA-N	280140	US10028961, Compound 293::US10172864, Compound 293::US10946023, Compound 293	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280140	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280140&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817463	378161690							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617667	COc1cccc(n1)-c1nc(N[C@H](C)C2CC2)nc(N[C@H](C)C2CC2)n1 |r|	InChI=1S/C19H26N6O/c1-11(13-7-8-13)20-18-23-17(15-5-4-6-16(22-15)26-3)24-19(25-18)21-12(2)14-9-10-14/h4-6,11-14H,7-10H2,1-3H3,(H2,20,21,23,24,25)	WYXMPHFGDDGKSR-UHFFFAOYSA-N	280141	US10028961, Compound 294::US10172864, Compound 294::US10946023, Compound 294	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280141	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280141&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817460	378161691							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617668	COCCOCC(C)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C20H27F3N6O2/c1-12(11-31-10-9-30-3)24-18-27-17(15-5-4-6-16(26-15)20(21,22)23)28-19(29-18)25-13(2)14-7-8-14/h4-6,12-14H,7-11H2,1-3H3,(H2,24,25,27,28,29)	OAYRAJOVHMVYGP-UHFFFAOYSA-N	280142	US10028961, Compound 295::US10172864, Compound 295::US10946023, Compound 295	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280142	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280142&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799237	378161692							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617669	FC(F)(F)Oc1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H23F7N6O/c22-19(23)8-4-12(5-9-19)29-17-32-16(14-2-1-3-15(31-14)35-21(26,27)28)33-18(34-17)30-13-6-10-20(24,25)11-7-13/h1-3,12-13H,4-11H2,(H2,29,30,32,33,34)	HSAOXCHGPDCXKT-UHFFFAOYSA-N	280143	US10028961, Compound 296::US10172864, Compound 296::US10946023, Compound 296	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280143	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280143&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817462	378161693							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617670	FC(F)(F)Oc1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H23F7N6O/c22-19(23)8-4-12(5-9-19)29-17-32-16(14-2-1-3-15(31-14)35-21(26,27)28)33-18(34-17)30-13-6-10-20(24,25)11-7-13/h1-3,12-13H,4-11H2,(H2,29,30,32,33,34)	HSAOXCHGPDCXKT-UHFFFAOYSA-N	280143	US10028961, Compound 296::US10172864, Compound 296::US10946023, Compound 296	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280143	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280143&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817462	378161693							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617671	FC(F)(F)c1n[nH]cc1-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H22F7N7/c20-17(21)5-1-10(2-6-17)28-15-30-14(12-9-27-33-13(12)19(24,25)26)31-16(32-15)29-11-3-7-18(22,23)8-4-11/h9-11H,1-8H2,(H,27,33)(H2,28,29,30,31,32)	WYHVNJNVMROQBY-UHFFFAOYSA-N	280144	US10028961, Compound 297::US10172864, Compound 297::US10946023, Compound 297	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280144	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280144&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817464	378161694							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617672	FC(F)(F)c1n[nH]cc1-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H22F7N7/c20-17(21)5-1-10(2-6-17)28-15-30-14(12-9-27-33-13(12)19(24,25)26)31-16(32-15)29-11-3-7-18(22,23)8-4-11/h9-11H,1-8H2,(H,27,33)(H2,28,29,30,31,32)	WYHVNJNVMROQBY-UHFFFAOYSA-N	280144	US10028961, Compound 297::US10172864, Compound 297::US10946023, Compound 297	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280144	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280144&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817464	378161694							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617673	CC(C)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C18H17F5N8/c1-9(2)26-15-29-14(13-25-7-5-11(28-13)18(21,22)23)30-16(31-15)27-10-4-6-24-12(8-10)17(3,19)20/h4-9H,1-3H3,(H2,24,26,27,29,30,31)	MNWAUMZTPYXVGO-UHFFFAOYSA-N	280145	US10028961, Compound 298::US10172864, Compound 298::US10946023, Compound 298	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280145	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280145&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798710	378161695							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617674	CC(C)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C18H17F5N8/c1-9(2)26-15-29-14(13-25-7-5-11(28-13)18(21,22)23)30-16(31-15)27-10-4-6-24-12(8-10)17(3,19)20/h4-9H,1-3H3,(H2,24,26,27,29,30,31)	MNWAUMZTPYXVGO-UHFFFAOYSA-N	280145	US10028961, Compound 298::US10172864, Compound 298::US10946023, Compound 298	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280145	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280145&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798710	378161695							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617676	Fc1ccc(cc1)[C@H]1C[C@@H](C1)Nc1nc(N[C@H]2C[C@@H](C2)c2ccc(F)cc2)nc(n1)-c1cccc(n1)C(F)(F)F |r,wU:18.22,7.7,wD:16.17,9.12,(11.22,.32,;9.89,-.45,;9.89,-1.99,;8.55,-2.76,;7.22,-1.99,;7.22,-.45,;8.55,.32,;5.89,-2.76,;5.49,-4.25,;4,-3.85,;4.4,-2.36,;2.67,-4.62,;1.33,-3.85,;,-4.62,;-1.33,-3.85,;-2.67,-4.62,;-4,-3.85,;-4.4,-2.36,;-5.89,-2.76,;-5.49,-4.25,;-7.22,-1.99,;-7.22,-.45,;-8.55,.32,;-9.89,-.45,;-11.22,.32,;-9.89,-1.99,;-8.55,-2.76,;-1.33,-2.31,;,-1.54,;1.33,-2.31,;;-1.33,.77,;-1.33,2.31,;,3.08,;1.33,2.31,;1.33,.77,;2.67,3.08,;2.67,4.62,;4,2.31,;4,3.85,)|	InChI=1S/C29H25F5N6/c30-20-8-4-16(5-9-20)18-12-22(13-18)35-27-38-26(24-2-1-3-25(37-24)29(32,33)34)39-28(40-27)36-23-14-19(15-23)17-6-10-21(31)11-7-17/h1-11,18-19,22-23H,12-15H2,(H2,35,36,38,39,40)	NMLSZZYWTRQLTB-UHFFFAOYSA-N	280146	US10028961, Compound 299::US10172864, Compound 299::US10946023, Compound 299	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280146	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280146&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817318	378161696							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617677	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cncc(c1)C(F)(F)F)C1CC1 |r|	InChI=1S/C19H23F3N6/c1-10(12-3-4-12)24-17-26-16(14-7-15(9-23-8-14)19(20,21)22)27-18(28-17)25-11(2)13-5-6-13/h7-13H,3-6H2,1-2H3,(H2,24,25,26,27,28)	ALVRRVSCSVEIIK-UHFFFAOYSA-N	280147	US10028961, Compound 300::US10172864, Compound 300::US10946023, Compound 300	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280147	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280147&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817346	378161697							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617678	Cc1nc(co1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H16F4N6O/c1-7-20-10(6-26-7)11-23-12(21-8-2-14(16,17)3-8)25-13(24-11)22-9-4-15(18,19)5-9/h6,8-9H,2-5H2,1H3,(H2,21,22,23,24,25)	YBHPSBQYBQRDEV-UHFFFAOYSA-N	280148	US10028961, Compound 301::US10172864, Compound 301::US10946023, Compound 301	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280148	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280148&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817319	378161698							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617679	Cc1nc(co1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H16F4N6O/c1-7-20-10(6-26-7)11-23-12(21-8-2-14(16,17)3-8)25-13(24-11)22-9-4-15(18,19)5-9/h6,8-9H,2-5H2,1H3,(H2,21,22,23,24,25)	YBHPSBQYBQRDEV-UHFFFAOYSA-N	280148	US10028961, Compound 301::US10172864, Compound 301::US10946023, Compound 301	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280148	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280148&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817319	378161698							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617680	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-n1cc(Cl)cn1	InChI=1S/C18H22ClF4N7/c19-11-9-24-30(10-11)16-28-14(25-12-1-5-17(20,21)6-2-12)27-15(29-16)26-13-3-7-18(22,23)8-4-13/h9-10,12-13H,1-8H2,(H2,25,26,27,28,29)	QSWMJNNVEMLNDB-UHFFFAOYSA-N	280149	US10028961, Compound 302::US10172864, Compound 302::US10946023, Compound 302	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280149	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280149&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817332	378161699							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617681	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-n1cc(Cl)cn1	InChI=1S/C18H22ClF4N7/c19-11-9-24-30(10-11)16-28-14(25-12-1-5-17(20,21)6-2-12)27-15(29-16)26-13-3-7-18(22,23)8-4-13/h9-10,12-13H,1-8H2,(H2,25,26,27,28,29)	QSWMJNNVEMLNDB-UHFFFAOYSA-N	280149	US10028961, Compound 302::US10172864, Compound 302::US10946023, Compound 302	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280149	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280149&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817332	378161699							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617683	C[C@@H](Nc1nc(NCC(C)(C)C(N)=O)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C19H24F3N7O/c1-10(11-7-8-11)25-17-28-14(12-5-4-6-13(26-12)19(20,21)22)27-16(29-17)24-9-18(2,3)15(23)30/h4-6,10-11H,7-9H2,1-3H3,(H2,23,30)(H2,24,25,27,28,29)	XTYWTUUCWNFNQP-UHFFFAOYSA-N	280150	US10028961, Compound 303::US10172864, Compound 303::US10946023, Compound 303	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280150	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280150&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817320	378161700							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617684	Cn1ccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H25F4N7/c1-30-11-6-14(29-30)15-26-16(24-12-2-7-18(20,21)8-3-12)28-17(27-15)25-13-4-9-19(22,23)10-5-13/h6,11-13H,2-5,7-10H2,1H3,(H2,24,25,26,27,28)	QCQLUIVJCWNARE-UHFFFAOYSA-N	280151	US10028961, Compound 304::US10172864, Compound 304::US10946023, Compound 304	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280151	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280151&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817330	378161701							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617685	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C1CC1	InChI=1S/C23H28F4N6/c24-22(25)10-6-15(7-11-22)28-20-31-19(18-3-1-2-17(30-18)14-4-5-14)32-21(33-20)29-16-8-12-23(26,27)13-9-16/h1-3,14-16H,4-13H2,(H2,28,29,31,32,33)	PNHZDKHPDZVPGP-UHFFFAOYSA-N	280152	US10028961, Compound 305::US10172864, Compound 305::US10946023, Compound 305	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280152	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280152&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799070	378161702							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617686	CC(CN1CCOCC1)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C21H28F3N7O/c1-13(12-31-8-10-32-11-9-31)25-19-28-18(16-4-3-5-17(27-16)21(22,23)24)29-20(30-19)26-14(2)15-6-7-15/h3-5,13-15H,6-12H2,1-2H3,(H2,25,26,28,29,30)	FAGQCPRWPNBUIH-UHFFFAOYSA-N	280153	US10028961, Compound 306::US10172864, Compound 306::US10946023, Compound 306	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280153	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280153&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799015	378161703							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617687	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(N)=O)C1CC1 |r|	InChI=1S/C19H25N7O/c1-10(12-6-7-12)21-18-24-17(15-5-3-4-14(23-15)16(20)27)25-19(26-18)22-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H2,20,27)(H2,21,22,24,25,26)	ANCUHZOTRVEMID-UHFFFAOYSA-N	280154	US10028961, Compound 307::US10172864, Compound 307::US10946023, Compound 307	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280154	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280154&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799230	378161704							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617688	FC(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H23F6N7/c21-14(22)13-5-10-27-15(30-13)16-31-17(28-11-1-6-19(23,24)7-2-11)33-18(32-16)29-12-3-8-20(25,26)9-4-12/h5,10-12,14H,1-4,6-9H2,(H2,28,29,31,32,33)	KCKMAAKVFCQNEN-UHFFFAOYSA-N	280155	US10028961, Compound 308::US10172864, Compound 308::US10946023, Compound 308	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280155	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280155&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466270	378161705							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617690	Oc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H23F5N6O/c21-13-1-2-14(32)28-15(13)16-29-17(26-11-3-7-19(22,23)8-4-11)31-18(30-16)27-12-5-9-20(24,25)10-6-12/h1-2,11-12H,3-10H2,(H,28,32)(H2,26,27,29,30,31)	LBPUKFIAHANDDC-UHFFFAOYSA-N	280156	US10028961, Compound 309::US10172864, Compound 309::US10946023, Compound 309	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280156	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280156&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799124	378161706							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617691	COC(=O)c1cccc(n1)-c1nc(N[C@H](C)C2CC2)nc(N[C@H](C)C2CC2)n1 |r|	InChI=1S/C20H26N6O2/c1-11(13-7-8-13)21-19-24-17(15-5-4-6-16(23-15)18(27)28-3)25-20(26-19)22-12(2)14-9-10-14/h4-6,11-14H,7-10H2,1-3H3,(H2,21,22,24,25,26)	COOHZFVAXQNVEL-UHFFFAOYSA-N	280157	US10028961, Compound 310::US10172864, Compound 310::US10946023, Compound 310	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280157	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280157&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799400	378161707							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617692	Cc1cc(no1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H16F4N6O/c1-7-2-10(25-26-7)11-22-12(20-8-3-14(16,17)4-8)24-13(23-11)21-9-5-15(18,19)6-9/h2,8-9H,3-6H2,1H3,(H2,20,21,22,23,24)	JWLFPLOMUNYBLN-UHFFFAOYSA-N	280158	US10028961, Compound 311::US10172864, Compound 311::US10946023, Compound 311	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280158	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280158&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817411	378161708							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617693	Cc1cc(no1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H16F4N6O/c1-7-2-10(25-26-7)11-22-12(20-8-3-14(16,17)4-8)24-13(23-11)21-9-5-15(18,19)6-9/h2,8-9H,3-6H2,1H3,(H2,20,21,22,23,24)	JWLFPLOMUNYBLN-UHFFFAOYSA-N	280158	US10028961, Compound 311::US10172864, Compound 311::US10946023, Compound 311	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280158	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280158&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817411	378161708							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617694	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-n1cc(C)cn1)C1CC1 |r|	InChI=1S/C17H25N7/c1-10-8-18-24(9-10)17-22-15(19-11(2)13-4-5-13)21-16(23-17)20-12(3)14-6-7-14/h8-9,11-14H,4-7H2,1-3H3,(H2,19,20,21,22,23)	CCTGXGIKECSYLR-UHFFFAOYSA-N	280159	US10028961, Compound 312::US10172864, Compound 312::US10946023, Compound 312	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280159	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280159&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817579	378161709							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617695	Fc1ccc(cc1)N1CC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C23H21F6N7/c24-13-4-6-16(7-5-13)36-11-15(12-36)31-21-34-19(17-2-1-3-18(32-17)23(27,28)29)33-20(35-21)30-14-8-9-22(25,26)10-14/h1-7,14-15H,8-12H2,(H2,30,31,33,34,35)	WKTDNXNWAJZYOL-UHFFFAOYSA-N	280160	US10028961, Compound 313::US10172864, Compound 313::US10946023, Compound 313	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280160	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280160&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817351	378161710							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617696	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cc(Cl)ccn1	InChI=1S/C20H23ClF4N6/c21-12-5-10-26-15(11-12)16-29-17(27-13-1-6-19(22,23)7-2-13)31-18(30-16)28-14-3-8-20(24,25)9-4-14/h5,10-11,13-14H,1-4,6-9H2,(H2,27,28,29,30,31)	LSGOKKOWCOIAGR-UHFFFAOYSA-N	280161	US10028961, Compound 314::US10172864, Compound 314::US10946023, Compound 314	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280161	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280161&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817483	378161711							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617697	COCCc1ccnc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C22H29F4N7O/c1-34-13-7-16-6-12-27-17(28-16)18-31-19(29-14-2-8-21(23,24)9-3-14)33-20(32-18)30-15-4-10-22(25,26)11-5-15/h6,12,14-15H,2-5,7-11,13H2,1H3,(H2,29,30,31,32,33)	IIDRMKULCOPTDM-UHFFFAOYSA-N	280162	US10028961, Compound 315::US10172864, Compound 315::US10946023, Compound 315	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280162	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280162&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466269	378161712							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617698	Cn1c(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)cc2ccccc12	InChI=1S/C23H20F5N7/c1-35-16-7-3-2-5-13(16)11-18(35)31-21-33-19(15-6-4-8-17(30-15)23(26,27)28)32-20(34-21)29-14-9-10-22(24,25)12-14/h2-8,11,14H,9-10,12H2,1H3,(H2,29,31,32,33,34)	LELUQJXOLYUADR-UHFFFAOYSA-N	280163	US10028961, Compound 316::US10172864, Compound 316::US10946023, Compound 316	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280163	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280163&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817449	378161713							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617699	Cc1nc(c[nH]1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H17F4N7/c1-7-20-6-10(21-7)11-24-12(22-8-2-14(16,17)3-8)26-13(25-11)23-9-4-15(18,19)5-9/h6,8-9H,2-5H2,1H3,(H,20,21)(H2,22,23,24,25,26)	LRORKNAAPJYJSX-UHFFFAOYSA-N	280164	US10028961, Compound 317::US10172864, Compound 317::US10946023, Compound 317	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280164	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280164&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817555	378161714							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617700	FC(F)(F)c1ccnc(c1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H23F7N6/c22-19(23)6-1-13(2-7-19)30-17-32-16(15-11-12(5-10-29-15)21(26,27)28)33-18(34-17)31-14-3-8-20(24,25)9-4-14/h5,10-11,13-14H,1-4,6-9H2,(H2,30,31,32,33,34)	CVGPCRWUHFXMHW-UHFFFAOYSA-N	280165	US10028961, Compound 318::US10172864, Compound 318::US10946023, Compound 318	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280165	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280165&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817556	378161715							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617701	Cc1nc(c[nH]1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C17H21F4N7/c1-9-22-8-12(23-9)13-26-14(24-10-2-4-16(18,19)6-10)28-15(27-13)25-11-3-5-17(20,21)7-11/h8,10-11H,2-7H2,1H3,(H,22,23)(H2,24,25,26,27,28)	WXUIXALGZVQUGH-UHFFFAOYSA-N	280166	US10028961, Compound 319::US10172864, Compound 319::US10946023, Compound 319	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280166	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280166&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817325	378161716							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617702	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(c1)C#N)C1CC1 |r|	InChI=1S/C20H24N6/c1-12(15-6-7-15)22-19-24-18(17-5-3-4-14(10-17)11-21)25-20(26-19)23-13(2)16-8-9-16/h3-5,10,12-13,15-16H,6-9H2,1-2H3,(H2,22,23,24,25,26)	XAPUEAYQMZYLNW-UHFFFAOYSA-N	280167	US10028961, Compound 320::US10172864, Compound 320::US10946023, Compound 320	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280167	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280167&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817299	378161717							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617703	COc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H25F5N6O/c1-33-15-3-2-14(22)16(29-15)17-30-18(27-12-4-8-20(23,24)9-5-12)32-19(31-17)28-13-6-10-21(25,26)11-7-13/h2-3,12-13H,4-11H2,1H3,(H2,27,28,30,31,32)	PUYRUGBORWDDDV-UHFFFAOYSA-N	280168	US10028961, Compound 321::US10172864, Compound 321::US10946023, Compound 321	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280168	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280168&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817329	378161718							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617704	COc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H25F5N6O/c1-33-15-3-2-14(22)16(29-15)17-30-18(27-12-4-8-20(23,24)9-5-12)32-19(31-17)28-13-6-10-21(25,26)11-7-13/h2-3,12-13H,4-11H2,1H3,(H2,27,28,30,31,32)	PUYRUGBORWDDDV-UHFFFAOYSA-N	280168	US10028961, Compound 321::US10172864, Compound 321::US10946023, Compound 321	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280168	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280168&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817329	378161718							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617705	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(OC(F)(F)F)c1)C1CC1 |r|	InChI=1S/C20H24F3N5O/c1-11(13-6-7-13)24-18-26-17(27-19(28-18)25-12(2)14-8-9-14)15-4-3-5-16(10-15)29-20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,26,27,28)	RTLORKKPLAXBLK-UHFFFAOYSA-N	280169	US10028961, Compound 322::US10172864, Compound 322::US10946023, Compound 322	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280169	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280169&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817309	378161719							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617706	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1ccnc(c1)C(F)(F)F)C1CC1 |r|	InChI=1S/C19H23F3N6/c1-10(12-3-4-12)24-17-26-16(14-7-8-23-15(9-14)19(20,21)22)27-18(28-17)25-11(2)13-5-6-13/h7-13H,3-6H2,1-2H3,(H2,24,25,26,27,28)	OZTHBVUYLQRNQU-UHFFFAOYSA-N	280170	US10028961, Compound 323::US10172864, Compound 323::US10946023, Compound 323	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280170	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280170&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817302	378161720							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617707	Cc1nc(co1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H24F4N6O/c1-11-24-14(10-30-11)15-27-16(25-12-2-6-18(20,21)7-3-12)29-17(28-15)26-13-4-8-19(22,23)9-5-13/h10,12-13H,2-9H2,1H3,(H2,25,26,27,28,29)	KBXOUHBWHZCWAK-UHFFFAOYSA-N	280171	US10028961, Compound 324::US10172864, Compound 324::US10946023, Compound 324	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280171	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280171&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817327	378161721							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617708	CC(C)(O)CNc1nc(Nc2cc(F)cc(F)c2)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C18H16F5N7O/c1-17(2,31)8-25-15-28-14(13-24-4-3-12(27-13)18(21,22)23)29-16(30-15)26-11-6-9(19)5-10(20)7-11/h3-7,31H,8H2,1-2H3,(H2,25,26,28,29,30)	MDLNQVWWUAJKJT-UHFFFAOYSA-N	280172	US10028961, Compound 325::US10172864, Compound 325::US10946023, Compound 325	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280172	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280172&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799047	378161722							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617709	CC(C)(O)CNc1nc(Nc2cc(F)cc(F)c2)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C18H16F5N7O/c1-17(2,31)8-25-15-28-14(13-24-4-3-12(27-13)18(21,22)23)29-16(30-15)26-11-6-9(19)5-10(20)7-11/h3-7,31H,8H2,1-2H3,(H2,25,26,28,29,30)	MDLNQVWWUAJKJT-UHFFFAOYSA-N	280172	US10028961, Compound 325::US10172864, Compound 325::US10946023, Compound 325	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280172	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280172&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799047	378161722							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617711	CN1CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H22F5N7/c1-31-8-6-12(10-31)26-17-29-15(13-3-2-4-14(27-13)19(22,23)24)28-16(30-17)25-11-5-7-18(20,21)9-11/h2-4,11-12H,5-10H2,1H3,(H2,25,26,28,29,30)	FKUYTXAMGGWNHC-UHFFFAOYSA-N	279946	US10028961, Compound 326::US10028961, Compound 96::US10172864, Compound 96::US10946023, Compound 326	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279946	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279946&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817313	378161496							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617713	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(O)n1)C1CC1 |r|	InChI=1S/C18H24N6O/c1-10(12-6-7-12)19-17-22-16(14-4-3-5-15(25)21-14)23-18(24-17)20-11(2)13-8-9-13/h3-5,10-13H,6-9H2,1-2H3,(H,21,25)(H2,19,20,22,23,24)	XCJURBVXBCWXNR-UHFFFAOYSA-N	280174	US10028961, Compound 327::US10172864, Compound 327::US10946023, Compound 327	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280174	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280174&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817341	378161723							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617714	Cc1nsc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C18H23F4N7S/c1-10-23-14(30-29-10)13-26-15(24-11-2-6-17(19,20)7-3-11)28-16(27-13)25-12-4-8-18(21,22)9-5-12/h11-12H,2-9H2,1H3,(H2,24,25,26,27,28)	YGASMFPIDZFMKN-UHFFFAOYSA-N	280175	US10028961, Compound 328::US10172864, Compound 328::US10946023, Compound 328	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280175	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280175&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817331	378161724							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617715	Cc1cc(no1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H24F4N6O/c1-11-10-14(29-30-11)15-26-16(24-12-2-6-18(20,21)7-3-12)28-17(27-15)25-13-4-8-19(22,23)9-5-13/h10,12-13H,2-9H2,1H3,(H2,24,25,26,27,28)	LHBMQURTVTWZJE-UHFFFAOYSA-N	280176	US10028961, Compound 329::US10172864, Compound 329::US10946023, Compound 329	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280176	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280176&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817558	378161725							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617716	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1ccn[nH]1	InChI=1S/C18H23F4N7/c19-17(20)6-1-11(2-7-17)24-15-26-14(13-5-10-23-29-13)27-16(28-15)25-12-3-8-18(21,22)9-4-12/h5,10-12H,1-4,6-9H2,(H,23,29)(H2,24,25,26,27,28)	JPXUIUIQYJBYGI-UHFFFAOYSA-N	280177	US10028961, Compound 330::US10172864, Compound 330::US10946023, Compound 330	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280177	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280177&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817574	378161726							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617717	CC(CN1CCCCC1)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C22H30F3N7/c1-14(13-32-11-4-3-5-12-32)26-20-29-19(17-7-6-8-18(28-17)22(23,24)25)30-21(31-20)27-15(2)16-9-10-16/h6-8,14-16H,3-5,9-13H2,1-2H3,(H2,26,27,29,30,31)	PQCFYGRRHLHCMI-UHFFFAOYSA-N	280178	US10028961, Compound 331::US10172864, Compound 331::US10946023, Compound 331	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280178	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280178&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799488	378161727							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617718	Cc1nc(c[nH]1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H25F4N7/c1-11-24-10-14(25-11)15-28-16(26-12-2-6-18(20,21)7-3-12)30-17(29-15)27-13-4-8-19(22,23)9-5-13/h10,12-13H,2-9H2,1H3,(H,24,25)(H2,26,27,28,29,30)	OMGWTZOTCFNMGJ-UHFFFAOYSA-N	280179	US10028961, Compound 332::US10172864, Compound 332::US10946023, Compound 332	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280179	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280179&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817562	378161728							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617719	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1nc(ns1)-c1ccccc1	InChI=1S/C23H25F4N7S/c24-22(25)10-6-15(7-11-22)28-20-31-18(19-30-17(34-35-19)14-4-2-1-3-5-14)32-21(33-20)29-16-8-12-23(26,27)13-9-16/h1-5,15-16H,6-13H2,(H2,28,29,31,32,33)	VEBDQVKKCIRACB-UHFFFAOYSA-N	280180	US10028961, Compound 333::US10172864, Compound 333::US10946023, Compound 333	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280180	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280180&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817500	378161729							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617793	C[C@@H](Nc1cc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)	MEKMADZCSPFPMP-UHFFFAOYSA-N	280255	US10028961, Compound 414::US10172864, Compound 414::US10946023, Compound 414	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280255	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280255&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817191	378161804							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617794	C[C@@H](Nc1cc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)	MEKMADZCSPFPMP-UHFFFAOYSA-N	280255	US10028961, Compound 414::US10172864, Compound 414::US10946023, Compound 414	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280255	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280255&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817191	378161804							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617796	C[C@@H](Nc1cc(N[C@@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)	MEKMADZCSPFPMP-UHFFFAOYSA-N	280256	US10028961, Compound 415::US10172864, Compound 415::US10946023, Compound 415	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280256	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280256&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817171	378161805							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617798	C[C@H](Nc1cc(N[C@@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)	MEKMADZCSPFPMP-UHFFFAOYSA-N	280257	US10028961, Compound 416::US10172864, Compound 416::US10946023, Compound 416	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280257	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280257&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817194	378161806							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617799	C[C@H](Nc1cc(N[C@@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)	MEKMADZCSPFPMP-UHFFFAOYSA-N	280257	US10028961, Compound 416::US10172864, Compound 416::US10946023, Compound 416	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280257	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280257&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817194	378161806							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617801	C[C@@H](Nc1cc(NC(C)(C)C)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C19H24F3N5/c1-11(12-8-9-12)23-15-10-16(27-18(2,3)4)26-17(25-15)13-6-5-7-14(24-13)19(20,21)22/h5-7,10-12H,8-9H2,1-4H3,(H2,23,25,26,27)	SICOBUZBFFTRIB-UHFFFAOYSA-N	280258	US10028961, Compound 417::US10172864, Compound 417::US10946023, Compound 417	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280258	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280258&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817175	378161807							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617803	C[C@@H](Nc1cc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C18H19ClF5N5/c1-10(18(22,23)24)25-14-9-15(26-11-5-7-17(20,21)8-6-11)29-16(28-14)12-3-2-4-13(19)27-12/h2-4,9-11H,5-8H2,1H3,(H2,25,26,28,29)	KKGDMBANXIMCDA-UHFFFAOYSA-N	316458	US10172864, Compound 418::US10946023, Compound 418	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316458	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316458&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817176	383542687							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617804	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC2)cc(NCC2CC2)n1	InChI=1S/C18H20F3N5/c19-18(20,21)14-3-1-2-13(24-14)17-25-15(22-9-11-4-5-11)8-16(26-17)23-10-12-6-7-12/h1-3,8,11-12H,4-7,9-10H2,(H2,22,23,25,26)	QEJQVKBULWEUGT-UHFFFAOYSA-N	280260	US10028961, Compound 419::US10172864, Compound 419::US10946023, Compound 419	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280260	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280260&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817553	378161809							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617805	CC(Nc1cc(NC(C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)	MEKMADZCSPFPMP-UHFFFAOYSA-N	280261	US10028961, Compound 420::US10172864, Compound 420::US10946023, Compound 420	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796521	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280261	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280261&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817543	378161810							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617806	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)cc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H23F7N6/c22-19(23)5-1-12(2-6-19)30-16-9-17(31-13-3-7-20(24,25)8-4-13)34-18(33-16)14-10-29-11-15(32-14)21(26,27)28/h9-13H,1-8H2,(H2,30,31,33,34)	UGJNNXSKMGDBMZ-UHFFFAOYSA-N	280262	US10028961, Compound 421::US10172864, Compound 421::US10946023, Compound 421	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280262	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280262&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817529	378161811							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617807	C[C@@H](Nc1nc(NC(C(F)(F)F)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C14H10ClF9N6/c1-5(12(16,17)18)25-10-27-8(6-3-2-4-7(15)26-6)28-11(30-10)29-9(13(19,20)21)14(22,23)24/h2-5,9H,1H3,(H2,25,27,28,29,30)	VTJODCQTJUKOPV-UHFFFAOYSA-N	279947	US10028961, Compound 100::US10172864, Compound 100::US10946023, Compound 100	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279947	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279947&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817515	378161497							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617808	C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)	QCZAWDGAVJMPTA-UHFFFAOYSA-N	279948	US10028961, Compound 101::US10172864, Compound 101::US10946023, Compound 101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279948	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279948&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817422	378161498							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617809	C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)	QCZAWDGAVJMPTA-UHFFFAOYSA-N	279948	US10028961, Compound 101::US10172864, Compound 101::US10946023, Compound 101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279948	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279948&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817422	378161498							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617811	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(N[C@@H]2CCC(F)(F)C2)n1 |r|	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	JWMKUJAOIPXYIG-UHFFFAOYSA-N	279949	US10028961, Compound 102::US10172864, Compound 102::US10946023, Compound 102	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279949	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279949&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799093	378161499							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617812	CCC(Nc1nc(NC(CC)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C16H17ClF6N6/c1-3-9(15(18,19)20)25-13-27-12(8-6-5-7-11(17)24-8)28-14(29-13)26-10(4-2)16(21,22)23/h5-7,9-10H,3-4H2,1-2H3,(H2,25,26,27,28,29)	SDUBFPITPDQUSW-UHFFFAOYSA-N	279950	US10028961, Compound 103::US10172864, Compound 103::US10946023, Compound 103	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279950	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279950&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817517	378161500							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617813	CC[C@@H](Nc1nc(N[C@H](CC)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C16H17ClF6N6/c1-3-9(15(18,19)20)25-13-27-12(8-6-5-7-11(17)24-8)28-14(29-13)26-10(4-2)16(21,22)23/h5-7,9-10H,3-4H2,1-2H3,(H2,25,26,27,28,29)	SDUBFPITPDQUSW-UHFFFAOYSA-N	279951	US10028961, Compound 104::US10172864, Compound 104::US10946023, Compound 104	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279951	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279951&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817514	378161501							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617814	CC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C20H22F6N6/c1-18(21,22)14-4-2-3-13(29-14)15-30-16(27-11-5-7-19(23,24)9-11)32-17(31-15)28-12-6-8-20(25,26)10-12/h2-4,11-12H,5-10H2,1H3,(H2,27,28,30,31,32)	RZUPVAWGQZNFEZ-UHFFFAOYSA-N	279952	US10028961, Compound 105::US10172864, Compound 105::US10946023, Compound 105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279952	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279952&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817521	378161502							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617815	Fc1cc(F)cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-n2ccc(n2)C(F)(F)F)c1	InChI=1S/C17H12F7N7/c18-8-3-9(19)5-10(4-8)25-13-27-14(26-11-6-16(20,21)7-11)29-15(28-13)31-2-1-12(30-31)17(22,23)24/h1-5,11H,6-7H2,(H2,25,26,27,28,29)	XSFFZJKIWXEYIL-UHFFFAOYSA-N	279953	US10028961, Compound 106::US10172864, Compound 106::US10946023, Compound 106	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279953	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279953&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799077	378161503							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617817	CC(Nc1nc(Nc2cc(F)cc(F)c2)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C16H11F8N7/c1-7(15(19,20)21)25-12-27-13(26-10-5-8(17)4-9(18)6-10)29-14(28-12)31-3-2-11(30-31)16(22,23)24/h2-7H,1H3,(H2,25,26,27,28,29)	AQCLVWSTMGVZRR-UHFFFAOYSA-N	279954	US10028961, Compound 107::US10172864, Compound 107::US10946023, Compound 107	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279954	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279954&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817516	378161504							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617818	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-n2ccc(n2)C(F)(F)F)c1	InChI=1S/C18H14F7N7/c19-9-5-10(20)7-12(6-9)27-15-28-14(26-11-1-3-17(21,22)8-11)29-16(30-15)32-4-2-13(31-32)18(23,24)25/h2,4-7,11H,1,3,8H2,(H2,26,27,28,29,30)	UFZDFINJOJHYMD-UHFFFAOYSA-N	279955	US10028961, Compound 108::US10172864, Compound 108::US10946023, Compound 108	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279955	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279955&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817518	378161505							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617819	CCC(Nc1nc(NC(CC)C2CC2)nc(n1)-c1cccc(Cl)n1)C1CC1	InChI=1S/C20H27ClN6/c1-3-14(12-8-9-12)23-19-25-18(16-6-5-7-17(21)22-16)26-20(27-19)24-15(4-2)13-10-11-13/h5-7,12-15H,3-4,8-11H2,1-2H3,(H2,23,24,25,26,27)	SDVGLHHVYYZRJZ-UHFFFAOYSA-N	279957	US10028961, Compound 110::US10172864, Compound 110::US10946023, Compound 110	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279957	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279957&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817125	378161507							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617821	FC(F)(F)c1cccc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(N[C@@H]2CCC(F)(F)C2)n1 |r|	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	JWMKUJAOIPXYIG-UHFFFAOYSA-N	279958	US10028961, Compound 111::US10172864, Compound 111::US10946023, Compound 111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279958	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279958&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817150	378161508							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617822	Fc1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-n2ccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C19H14F6N8/c20-11-5-10(9-26)6-13(7-11)28-16-29-15(27-12-1-3-18(21,22)8-12)30-17(31-16)33-4-2-14(32-33)19(23,24)25/h2,4-7,12H,1,3,8H2,(H2,27,28,29,30,31)	GOMGSGWMVHCJSA-UHFFFAOYSA-N	279959	US10028961, Compound 112::US10172864, Compound 112::US10946023, Compound 112	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279959	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279959&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817138	378161509							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617823	FC1(F)CCC(C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(Cl)n1	InChI=1S/C18H19ClF4N6/c19-13-3-1-2-12(26-13)14-27-15(24-10-4-6-17(20,21)8-10)29-16(28-14)25-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,24,25,27,28,29)	WFTCEDYVKXKHBE-UHFFFAOYSA-N	279960	US10028961, Compound 113::US10172864, Compound 113::US10946023, Compound 113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279960	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279960&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817141	378161510							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617825	FC(F)(F)c1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(Cl)n2)ccn1	InChI=1S/C19H15ClF5N7/c20-14-3-1-2-12(29-14)15-30-16(27-10-5-7-26-13(8-10)19(23,24)25)32-17(31-15)28-11-4-6-18(21,22)9-11/h1-3,5,7-8,11H,4,6,9H2,(H2,26,27,28,30,31,32)	GCDKECOSGNFZAP-UHFFFAOYSA-N	279962	US10028961, Compound 115::US10172864, Compound 115::US10946023, Compound 115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279962	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279962&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798735	378161512							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617826	FC(F)(F)c1cncc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C19H14F8N8/c20-17(21)3-1-10(6-17)31-16-34-14(11-7-28-8-13(32-11)19(25,26)27)33-15(35-16)30-9-2-4-29-12(5-9)18(22,23)24/h2,4-5,7-8,10H,1,3,6H2,(H2,29,30,31,33,34,35)	ONCVYPCVWHYEJW-UHFFFAOYSA-N	279963	US10028961, Compound 116::US10172864, Compound 116::US10946023, Compound 116	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279963	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279963&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799248	378161513							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617827	FC(F)(F)c1cncc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C19H14F8N8/c20-17(21)3-1-10(6-17)31-16-34-14(11-7-28-8-13(32-11)19(25,26)27)33-15(35-16)30-9-2-4-29-12(5-9)18(22,23)24/h2,4-5,7-8,10H,1,3,6H2,(H2,29,30,31,33,34,35)	ONCVYPCVWHYEJW-UHFFFAOYSA-N	279963	US10028961, Compound 116::US10172864, Compound 116::US10946023, Compound 116	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279963	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279963&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799248	378161513							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617829	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(N[C@H]2CCC(F)(F)C2)n1 |r|	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	JWMKUJAOIPXYIG-UHFFFAOYSA-N	279965	US10028961, Compound 118::US10172864, Compound 118::US10946023, Compound 118	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279965	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279965&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817143	378161515							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617830	CC(Nc1nc(Nc2cc(F)cc(c2)C#N)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C17H11F7N8/c1-8(16(19,20)21)26-13-28-14(27-11-5-9(7-25)4-10(18)6-11)30-15(29-13)32-3-2-12(31-32)17(22,23)24/h2-6,8H,1H3,(H2,26,27,28,29,30)	WXBOZLIIKJDCRJ-UHFFFAOYSA-N	279966	US10028961, Compound 119::US10172864, Compound 119::US10946023, Compound 119	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279966	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279966&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817540	378161516							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617831	Fc1cc(F)cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2cncc(Cl)n2)c1	InChI=1S/C17H12ClF4N7/c18-13-7-23-6-12(26-13)14-27-15(24-10-2-8(19)1-9(20)3-10)29-16(28-14)25-11-4-17(21,22)5-11/h1-3,6-7,11H,4-5H2,(H2,24,25,27,28,29)	DJUDMNYUQIPAHU-UHFFFAOYSA-N	279967	US10028961, Compound 120::US10172864, Compound 120::US10946023, Compound 120	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279967	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279967&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799523	378161517							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617832	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-n1ccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C17H22F3N7/c1-9(11-3-4-11)21-14-23-15(22-10(2)12-5-6-12)25-16(24-14)27-8-7-13(26-27)17(18,19)20/h7-12H,3-6H2,1-2H3,(H2,21,22,23,24,25)	ZFCNVKABVPLJJM-UHFFFAOYSA-N	279968	US10028961, Compound 121::US10172864, Compound 121::US10946023, Compound 121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279968	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279968&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817536	378161518							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617833	Fc1cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2nc(cs2)C(F)(F)F)cc(c1)C#N	InChI=1S/C18H11F6N7S/c19-9-1-8(6-25)2-10(3-9)26-15-29-13(14-28-12(7-32-14)18(22,23)24)30-16(31-15)27-11-4-17(20,21)5-11/h1-3,7,11H,4-5H2,(H2,26,27,29,30,31)	MHTOHBOHQAYWJP-UHFFFAOYSA-N	279969	US10028961, Compound 122::US10172864, Compound 122::US10946023, Compound 122	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279969	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279969&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799023	378161519							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617834	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)c1	InChI=1S/C20H15F7N6/c21-10-6-11(22)8-13(7-10)29-18-32-16(14-2-1-3-15(30-14)20(25,26)27)31-17(33-18)28-12-4-5-19(23,24)9-12/h1-3,6-8,12H,4-5,9H2,(H2,28,29,31,32,33)	DTFRDAWQNHNMEU-UHFFFAOYSA-N	279970	US10028961, Compound 123::US10172864, Compound 123::US10946023, Compound 123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279970	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279970&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798777	378161520							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617835	Fc1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C21H15F6N7/c22-12-6-11(10-28)7-14(8-12)30-19-33-17(15-2-1-3-16(31-15)21(25,26)27)32-18(34-19)29-13-4-5-20(23,24)9-13/h1-3,6-8,13H,4-5,9H2,(H2,29,30,32,33,34)	NTKHRYLRDAXKRH-UHFFFAOYSA-N	279971	US10028961, Compound 124::US10172864, Compound 124::US10946023, Compound 124	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279971	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279971&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799282	378161521							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617836	FC(F)(F)c1ccn(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H14F7N7/c16-13(17)3-7(4-13)23-10-25-11(24-8-5-14(18,19)6-8)27-12(26-10)29-2-1-9(28-29)15(20,21)22/h1-2,7-8H,3-6H2,(H2,23,24,25,26,27)	NYHCCPXGTKQDAW-UHFFFAOYSA-N	279973	US10028961, Compound 126::US10172864, Compound 126::US10946023, Compound 126	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279973	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279973&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817544	378161523							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617837	FC1(F)CCC(C1)Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(Cl)n1	InChI=1S/C22H19ClF2N8/c23-17-3-1-2-15(30-17)18-31-19(33-20(32-18)29-14-4-6-22(24,25)11-14)28-13-5-9-27-16(10-13)21(12-26)7-8-21/h1-3,5,9-10,14H,4,6-8,11H2,(H2,27,28,29,31,32,33)	ZENVCUIOSQAXHI-UHFFFAOYSA-N	279974	US10028961, Compound 127::US10172864, Compound 127::US10946023, Compound 127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279974	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279974&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799128	378161524							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617839	FC(F)(F)c1csc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H13F7N6S/c16-13(17)1-6(2-13)23-11-26-9(10-25-8(5-29-10)15(20,21)22)27-12(28-11)24-7-3-14(18,19)4-7/h5-7H,1-4H2,(H2,23,24,26,27,28)	DSJXHLDOLTTWGN-UHFFFAOYSA-N	279975	US10028961, Compound 128::US10172864, Compound 128::US10946023, Compound 128	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279975	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279975&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817465	378161525							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617840	CC(Nc1nc(NC(C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)	QCZAWDGAVJMPTA-UHFFFAOYSA-N	279977	US10028961, Compound 130::US10172864, Compound 130::US10946023, Compound 130	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279977	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279977&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817435	378161527							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617841	Clc1cccc(n1)-c1nc(NC(C2CC2)C2CC2)nc(NC(C2CC2)C2CC2)n1	InChI=1S/C22H27ClN6/c23-17-3-1-2-16(24-17)20-27-21(25-18(12-4-5-12)13-6-7-13)29-22(28-20)26-19(14-8-9-14)15-10-11-15/h1-3,12-15,18-19H,4-11H2,(H2,25,26,27,28,29)	UYZPRJVBJGBQLI-UHFFFAOYSA-N	279978	US10028961, Compound 131::US10172864, Compound 131::US10946023, Compound 131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279978	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279978&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817455	378161528							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617842	Fc1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2nc(cs2)C(F)(F)F)cc(c1)[N+]#[C-]	InChI=1S/C19H13F6N7S/c1-26-11-4-9(20)5-12(6-11)28-17-31-14(15-29-13(8-33-15)19(23,24)25)30-16(32-17)27-10-2-3-18(21,22)7-10/h4-6,8,10H,2-3,7H2,(H2,27,28,30,31,32)	KEBOTYHGXMTVHD-UHFFFAOYSA-N	279979	US10028961, Compound 132::US10172864, Compound 132	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279979	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279979&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123723292	378161529							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617843	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1 |r|	InChI=1S/C23H19F5N8/c24-22(25)6-4-14(11-22)32-20-35-18(15-2-1-3-16(33-15)23(26,27)28)34-19(36-20)31-13-5-9-30-17(10-13)21(12-29)7-8-21/h1-3,5,9-10,14H,4,6-8,11H2,(H2,30,31,32,34,35,36)	FQOVWGJWJAOWBO-UHFFFAOYSA-N	279980	US10028961, Compound 133::US10172864, Compound 133::US10946023, Compound 133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279980	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279980&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817510	378161530							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617845	CC(Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(Cl)n1)C(F)(F)F	InChI=1S/C20H16ClF3N8/c1-11(20(22,23)24)27-17-30-16(13-3-2-4-15(21)29-13)31-18(32-17)28-12-5-8-26-14(9-12)19(10-25)6-7-19/h2-5,8-9,11H,6-7H2,1H3,(H2,26,27,28,30,31,32)	CFSIYYWIWLPLNQ-UHFFFAOYSA-N	279981	US10028961, Compound 134::US10172864, Compound 134::US10946023, Compound 134	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279981	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279981&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817443	378161531							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617846	C[C@@H](Nc1nc(N[C@@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)	QCZAWDGAVJMPTA-UHFFFAOYSA-N	279983	US10028961, Compound 136::US10172864, Compound 136::US10946023, Compound 136	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279983	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279983&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817448	378161533							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617847	FC(F)(F)c1cccc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1 |r|	InChI=1S/C23H19F5N8/c24-22(25)6-4-14(11-22)32-20-35-18(15-2-1-3-16(33-15)23(26,27)28)34-19(36-20)31-13-5-9-30-17(10-13)21(12-29)7-8-21/h1-3,5,9-10,14H,4,6-8,11H2,(H2,30,31,32,34,35,36)	FQOVWGJWJAOWBO-UHFFFAOYSA-N	279984	US10028961, Compound 137::US10172864, Compound 137::US10946023, Compound 137	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279984	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279984&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799135	378161534							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617849	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H18F7N7/c19-16(20)3-1-9(5-16)27-14-30-13(11-7-26-8-12(29-11)18(23,24)25)31-15(32-14)28-10-2-4-17(21,22)6-10/h7-10H,1-6H2,(H2,27,28,30,31,32)	YWUBJNPVIIBDPD-UHFFFAOYSA-N	279985	US10028961, Compound 138::US10172864, Compound 138::US10946023, Compound 138	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279985	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279985&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817513	378161535							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617850	Fc1cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-n2ccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C18H12F6N8/c19-10-3-9(8-25)4-11(5-10)26-14-28-15(27-12-6-17(20,21)7-12)30-16(29-14)32-2-1-13(31-32)18(22,23)24/h1-5,12H,6-7H2,(H2,26,27,28,29,30)	LDOFFBDPIFZNNG-UHFFFAOYSA-N	279987	US10028961, Compound 140::US10172864, Compound 140::US10946023, Compound 140	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279987	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279987&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799247	378161537							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617851	CC(Nc1nc(NC(C)C(F)(F)F)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C13H12F9N7/c1-5(11(14,15)16)23-8-25-9(24-6(2)12(17,18)19)27-10(26-8)29-4-3-7(28-29)13(20,21)22/h3-6H,1-2H3,(H2,23,24,25,26,27)	FYQXPMJBVPBLMP-UHFFFAOYSA-N	279988	US10028961, Compound 141::US10172864, Compound 141::US10946023, Compound 141	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279988	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279988&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817582	378161538							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617852	C[C@H](Nc1nc(N[C@@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)	QCZAWDGAVJMPTA-UHFFFAOYSA-N	279989	US10028961, Compound 142::US10172864, Compound 142::US10946023, Compound 142	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279989	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279989&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817339	378161539							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617853	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H19F7N6/c20-17(21)6-4-10(5-7-17)27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-11-8-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	ACLXKIHIMONNBV-UHFFFAOYSA-N	279990	US10028961, Compound 143::US10172864, Compound 143::US10946023, Compound 143	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279990	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279990&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817512	378161540							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617854	FC1(F)CC(C1)Nc1nc(NC2CC(F)(F)C2)nc(n1)-c1cncc(Cl)n1	InChI=1S/C15H14ClF4N7/c16-10-6-21-5-9(24-10)11-25-12(22-7-1-14(17,18)2-7)27-13(26-11)23-8-3-15(19,20)4-8/h5-8H,1-4H2,(H2,22,23,25,26,27)	YLBDZIMKQYQWBZ-UHFFFAOYSA-N	279991	US10028961, Compound 144::US10172864, Compound 144::US10946023, Compound 144	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279991	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279991&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817496	378161541							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617855	FC(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C17H16F6N6/c18-12(19)10-2-1-3-11(26-10)13-27-14(24-8-4-16(20,21)5-8)29-15(28-13)25-9-6-17(22,23)7-9/h1-3,8-9,12H,4-7H2,(H2,24,25,27,28,29)	CMDVCIGBLUTSCG-UHFFFAOYSA-N	279992	US10028961, Compound 145::US10172864, Compound 145::US10946023, Compound 145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279992	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279992&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466129	378161542							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617856	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C17H18F7N7/c18-15(19)4-1-9(7-15)25-12-27-13(26-10-2-5-16(20,21)8-10)29-14(28-12)31-6-3-11(30-31)17(22,23)24/h3,6,9-10H,1-2,4-5,7-8H2,(H2,25,26,27,28,29)	MLJRZPLHOBYNMG-UHFFFAOYSA-N	279993	US10028961, Compound 146::US10172864, Compound 146::US10946023, Compound 146	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279993	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279993&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817473	378161543							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617857	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cncc(Cl)n1	InChI=1S/C19H22ClF4N7/c20-14-10-25-9-13(28-14)15-29-16(26-11-1-5-18(21,22)6-2-11)31-17(30-15)27-12-3-7-19(23,24)8-4-12/h9-12H,1-8H2,(H2,26,27,29,30,31)	MEWHAARPVJKYDP-UHFFFAOYSA-N	279994	US10028961, Compound 147::US10172864, Compound 147::US10946023, Compound 147	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279994	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279994&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817495	378161544							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617858	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C17H15F7N6/c18-15(19)4-8(5-15)25-13-28-12(10-2-1-3-11(27-10)17(22,23)24)29-14(30-13)26-9-6-16(20,21)7-9/h1-3,8-9H,4-7H2,(H2,25,26,28,29,30)	GJNPRCBREKXFRM-UHFFFAOYSA-N	279996	US10028961, Compound 149::US10172864, Compound 149::US10946023, Compound 149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279996	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279996&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817132	378161546							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617859	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C23H19F5N8/c1-29-21(8-9-21)17-11-13(6-10-30-17)31-19-34-18(15-3-2-4-16(33-15)23(26,27)28)35-20(36-19)32-14-5-7-22(24,25)12-14/h2-4,6,10-11,14H,5,7-9,12H2,(H2,30,31,32,34,35,36)	LVLCYRFGYKSVJF-UHFFFAOYSA-N	279998	US10028961, Compound 151::US10172864, Compound 151	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279998	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279998&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123318205	378161548							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617860	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccccc3C2)n1	InChI=1S/C23H21F5N6/c24-22(25)9-8-15(12-22)29-20-32-19(17-6-3-7-18(31-17)23(26,27)28)33-21(34-20)30-16-10-13-4-1-2-5-14(13)11-16/h1-7,15-16H,8-12H2,(H2,29,30,32,33,34)	WFJGUJXRROVRQM-UHFFFAOYSA-N	279999	US10028961, Compound 152::US10172864, Compound 152::US10946023, Compound 152	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=279999	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=279999&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817119	378161549							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617861	Nc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2cc(F)cc(F)c2)n1	InChI=1S/C19H16F5N7/c20-9-5-10(21)7-12(6-9)27-18-30-16(15-13(22)1-2-14(25)28-15)29-17(31-18)26-11-3-4-19(23,24)8-11/h1-2,5-7,11H,3-4,8H2,(H2,25,28)(H2,26,27,29,30,31)	QJZUODUNLOWRRS-UHFFFAOYSA-N	280000	US10028961, Compound 153::US10172864, Compound 153::US10946023, Compound 153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280000	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280000&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799273	378161550							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617862	Fc1cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C20H13F6N7/c21-11-4-10(9-27)5-12(6-11)28-17-31-16(14-2-1-3-15(30-14)20(24,25)26)32-18(33-17)29-13-7-19(22,23)8-13/h1-6,13H,7-8H2,(H2,28,29,31,32,33)	NLDPPNGLSHUYFG-UHFFFAOYSA-N	280001	US10028961, Compound 154::US10172864, Compound 154::US10946023, Compound 154	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280001	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280001&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817126	378161551							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617863	CC(F)(F)c1nc(cs1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H20F6N6S/c1-16(19,20)13-27-11(8-31-13)12-28-14(25-9-2-4-17(21,22)6-9)30-15(29-12)26-10-3-5-18(23,24)7-10/h8-10H,2-7H2,1H3,(H2,25,26,28,29,30)	OMZLJEXLAIMEOS-UHFFFAOYSA-N	280002	US10028961, Compound 155::US10172864, Compound 155::US10946023, Compound 155	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280002	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280002&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817127	378161552							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617864	CC(Nc1nc(NC(C)C(F)(F)F)nc(n1)-c1cncc(Cl)n1)C(F)(F)F	InChI=1S/C13H12ClF6N7/c1-5(12(15,16)17)22-10-25-9(7-3-21-4-8(14)24-7)26-11(27-10)23-6(2)13(18,19)20/h3-6H,1-2H3,(H2,22,23,25,26,27)	QETWKMKQNIKDLH-UHFFFAOYSA-N	280003	US10028961, Compound 156::US10172864, Compound 156::US10946023, Compound 156	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280003	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280003&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817111	378161553							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617865	FC1(F)CCCC1Nc1nc(NC2CCCC2(F)F)nc(n1)-c1cccc(Cl)n1	InChI=1S/C18H19ClF4N6/c19-13-7-1-4-10(24-13)14-27-15(25-11-5-2-8-17(11,20)21)29-16(28-14)26-12-6-3-9-18(12,22)23/h1,4,7,11-12H,2-3,5-6,8-9H2,(H2,25,26,27,28,29)	PDSKCDIBFYQGCE-UHFFFAOYSA-N	280004	US10028961, Compound 157::US10172864, Compound 157::US10946023, Compound 157	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280004	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280004&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817134	378161554							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617866	FC(F)(F)c1cccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C20H15F8N7/c21-18(22)6-4-11(9-18)31-17-34-15(12-2-1-3-13(32-12)19(23,24)25)33-16(35-17)30-10-5-7-29-14(8-10)20(26,27)28/h1-3,5,7-8,11H,4,6,9H2,(H2,29,30,31,33,34,35)	PDXMOPYZKDLAPA-UHFFFAOYSA-N	280005	US10028961, Compound 158::US10172864, Compound 158::US10946023, Compound 158	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280005	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280005&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799020	378161555							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617868	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2nc(cs2)C(F)(F)F)c1	InChI=1S/C18H13F7N6S/c19-8-3-9(20)5-11(4-8)27-16-30-13(14-28-12(7-32-14)18(23,24)25)29-15(31-16)26-10-1-2-17(21,22)6-10/h3-5,7,10H,1-2,6H2,(H2,26,27,29,30,31)	YXCYCZLJJZKMJO-UHFFFAOYSA-N	280006	US10028961, Compound 159::US10172864, Compound 159::US10946023, Compound 159	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280006	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280006&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817493	378161556							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617869	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F7N7/c21-18(22)5-1-11(2-6-18)29-16-32-15(13-9-28-10-14(31-13)20(25,26)27)33-17(34-16)30-12-3-7-19(23,24)8-4-12/h9-12H,1-8H2,(H2,29,30,32,33,34)	SUGBJFIPDULVRS-UHFFFAOYSA-N	280007	US10028961, Compound 160::US10172864, Compound 160::US10946023, Compound 160	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280007	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280007&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817538	378161557							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617871	FC(F)(F)c1cncc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H14F7N7/c17-14(18)1-7(2-14)25-12-28-11(9-5-24-6-10(27-9)16(21,22)23)29-13(30-12)26-8-3-15(19,20)4-8/h5-8H,1-4H2,(H2,25,26,28,29,30)	BJUUMSAHTGGBTK-UHFFFAOYSA-N	280008	US10028961, Compound 161::US10172864, Compound 161::US10946023, Compound 161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280008	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280008&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817567	378161558							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617873	CC(C)(C)Nc1nc(Nc2ccnc(c2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H17F3N8/c1-18(2,3)30-17-28-15(13-5-4-6-14(26-13)19(20,21)22)27-16(29-17)25-11-7-8-24-12(9-11)10-23/h4-9H,1-3H3,(H2,24,25,27,28,29,30)	AJDWHCKBPZAYQS-UHFFFAOYSA-N	280009	US10028961, Compound 162::US10172864, Compound 162::US10946023, Compound 162	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280009	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280009&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799392	378161559							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617874	CC(F)(F)c1cc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)ccn1	InChI=1S/C21H18F7N7/c1-19(22,23)15-9-11(6-8-29-15)30-17-33-16(13-3-2-4-14(32-13)21(26,27)28)34-18(35-17)31-12-5-7-20(24,25)10-12/h2-4,6,8-9,12H,5,7,10H2,1H3,(H2,29,30,31,33,34,35)	RJZGABPOSOZJRY-UHFFFAOYSA-N	280010	US10028961, Compound 163::US10172864, Compound 163::US10946023, Compound 163	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280010	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280010&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817586	378161560							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617875	Fc1cc(Nc2nc(NC3CCC(F)(F)CC3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)C#N	InChI=1S/C22H17F6N7/c23-13-8-12(11-29)9-15(10-13)31-20-34-18(16-2-1-3-17(32-16)22(26,27)28)33-19(35-20)30-14-4-6-21(24,25)7-5-14/h1-3,8-10,14H,4-7H2,(H2,30,31,33,34,35)	RAQUPWWEGSOPEV-UHFFFAOYSA-N	280011	US10028961, Compound 164::US10172864, Compound 164::US10946023, Compound 164	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280011	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280011&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817554	378161561							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617876	Nc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2cc(F)cc(F)c2)n1	InChI=1S/C20H18F5N7/c21-10-7-11(22)9-13(8-10)28-19-31-17(16-14(23)1-2-15(26)29-16)30-18(32-19)27-12-3-5-20(24,25)6-4-12/h1-2,7-9,12H,3-6H2,(H2,26,29)(H2,27,28,30,31,32)	JAYZPFRYKWCBQZ-UHFFFAOYSA-N	280012	US10028961, Compound 165::US10172864, Compound 165::US10946023, Compound 165	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280012	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280012&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799099	378161562							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617877	C[C@@H](Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(Cl)n1)C1CC1 |r|	InChI=1S/C22H21ClN8/c1-13(14-5-6-14)26-20-29-19(16-3-2-4-18(23)28-16)30-21(31-20)27-15-7-10-25-17(11-15)22(12-24)8-9-22/h2-4,7,10-11,13-14H,5-6,8-9H2,1H3,(H2,25,26,27,29,30,31)	YPMMASFCPXGGFB-UHFFFAOYSA-N	280014	US10028961, Compound 167::US10172864, Compound 167::US10946023, Compound 167	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280014	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280014&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799158	378161564							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617879	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C22H17F5N8/c1-28-20(6-7-20)16-9-12(5-8-29-16)30-18-33-17(14-3-2-4-15(32-14)22(25,26)27)34-19(35-18)31-13-10-21(23,24)11-13/h2-5,8-9,13H,6-7,10-11H2,(H2,29,30,31,33,34,35)	MNROPBMECNHKDS-UHFFFAOYSA-N	280015	US10028961, Compound 168::US10172864, Compound 168	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280015	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280015&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123886256	378161565							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617881	FC(F)(F)c1ccn(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C20H16F5N9/c1-26-18(4-5-18)14-8-11(2-6-27-14)28-15-30-16(29-12-9-19(21,22)10-12)32-17(31-15)34-7-3-13(33-34)20(23,24)25/h2-3,6-8,12H,4-5,9-10H2,(H2,27,28,29,30,31,32)	BYFJDMHRGJRSCN-UHFFFAOYSA-N	280016	US10028961, Compound 169::US10172864, Compound 169	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280016	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280016&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124026281	378161566							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617882	FC(F)(F)c1nc(cs1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H13F7N6S/c16-13(17)1-6(2-13)23-11-26-9(8-5-29-10(25-8)15(20,21)22)27-12(28-11)24-7-3-14(18,19)4-7/h5-7H,1-4H2,(H2,23,24,26,27,28)	PFVOIDGYPOBGID-UHFFFAOYSA-N	280017	US10028961, Compound 170::US10172864, Compound 170::US10946023, Compound 170	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280017	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280017&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817334	378161567							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617883	CC(Nc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C18H12F9N7/c1-8(16(19,20)21)29-14-32-13(10-3-2-4-11(31-10)17(22,23)24)33-15(34-14)30-9-5-6-28-12(7-9)18(25,26)27/h2-8H,1H3,(H2,28,29,30,32,33,34)	RJRSWUFHCKWNQG-UHFFFAOYSA-N	280018	US10028961, Compound 171::US10172864, Compound 171::US10946023, Compound 171	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280018	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280018&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799090	378161568							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617884	FC(F)(F)c1cccc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C20H15F8N7/c21-18(22)6-4-11(9-18)31-17-34-15(12-2-1-3-13(32-12)19(23,24)25)33-16(35-17)30-10-5-7-29-14(8-10)20(26,27)28/h1-3,5,7-8,11H,4,6,9H2,(H2,29,30,31,33,34,35)	PDXMOPYZKDLAPA-UHFFFAOYSA-N	280019	US10028961, Compound 172::US10172864, Compound 172::US10946023, Compound 172	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280019	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280019&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798963	378161569							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617885	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C18H14F8N8/c19-16(20)4-1-10(8-16)29-14-30-13(28-9-2-5-27-12(7-9)18(24,25)26)31-15(32-14)34-6-3-11(33-34)17(21,22)23/h2-3,5-7,10H,1,4,8H2,(H2,27,28,29,30,31,32)	RACFSMUYWZWUMF-UHFFFAOYSA-N	280020	US10028961, Compound 173::US10172864, Compound 173::US10946023, Compound 173	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280020	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280020&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798964	378161570							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617886	FC(F)(F)c1ccn(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1 |r|	InChI=1S/C21H18F5N9/c1-27-19(6-7-19)15-10-12(3-8-28-15)29-16-31-17(30-13-2-5-20(22,23)11-13)33-18(32-16)35-9-4-14(34-35)21(24,25)26/h3-4,8-10,13H,2,5-7,11H2,(H2,28,29,30,31,32,33)	ZSYUHTUAGISLHX-UHFFFAOYSA-N	280021	US10028961, Compound 174::US10172864, Compound 174	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280021	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280021&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123271414	378161571							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617888	Fc1cc(Nc2nc(NCC3CC3)nc(n2)-c2cccc(n2)C(F)(F)F)cc(c1)[N+]#[C-]	InChI=1S/C20H15F4N7/c1-25-13-7-12(21)8-14(9-13)27-19-30-17(29-18(31-19)26-10-11-5-6-11)15-3-2-4-16(28-15)20(22,23)24/h2-4,7-9,11H,5-6,10H2,(H2,26,27,29,30,31)	JVFNMBJVSBMSCG-UHFFFAOYSA-N	280022	US10028961, Compound 175::US10172864, Compound 175	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280022	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280022&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123300524	378161572							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617889	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H22F7N7/c20-17(21)6-1-11(2-7-17)27-14-29-15(28-12-3-8-18(22,23)9-4-12)31-16(30-14)33-10-5-13(32-33)19(24,25)26/h5,10-12H,1-4,6-9H2,(H2,27,28,29,30,31)	SLPLEYMIEBFOSW-UHFFFAOYSA-N	280023	US10028961, Compound 176::US10172864, Compound 176::US10946023, Compound 176	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280023	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280023&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817355	378161573							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617890	CC(Nc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C16H11F9N8/c1-7(14(17,18)19)27-11-29-12(28-8-2-4-26-10(6-8)16(23,24)25)31-13(30-11)33-5-3-9(32-33)15(20,21)22/h2-7H,1H3,(H2,26,27,28,29,30,31)	ORPDRKJAHZEOLR-UHFFFAOYSA-N	280024	US10028961, Compound 177::US10172864, Compound 177::US10946023, Compound 177	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280024	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280024&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817357	378161574							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617891	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H15F8N7/c21-18(22)6-4-11(9-18)31-17-34-15(12-2-1-3-13(32-12)19(23,24)25)33-16(35-17)30-10-5-7-29-14(8-10)20(26,27)28/h1-3,5,7-8,11H,4,6,9H2,(H2,29,30,31,33,34,35)	PDXMOPYZKDLAPA-UHFFFAOYSA-N	280025	US10028961, Compound 178::US10172864, Compound 178::US10946023, Compound 178	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280025	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280025&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798985	378161575							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617893	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C18H14F5N9/c19-17(20)4-1-11(8-17)27-15-28-14(26-10-2-5-25-12(7-10)9-24)29-16(30-15)32-6-3-13(31-32)18(21,22)23/h2-3,5-7,11H,1,4,8H2,(H2,25,26,27,28,29,30)	LUJOXCPZQNCMMB-UHFFFAOYSA-N	280026	US10028961, Compound 179::US10172864, Compound 179::US10946023, Compound 179	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280026	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280026&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817116	378161576							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617894	CC[C@H](Nc1nc(N[C@@H](CC)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C16H17ClF6N6/c1-3-9(15(18,19)20)25-13-27-12(8-6-5-7-11(17)24-8)28-14(29-13)26-10(4-2)16(21,22)23/h5-7,9-10H,3-4H2,1-2H3,(H2,25,26,27,28,29)	SDUBFPITPDQUSW-UHFFFAOYSA-N	280027	US10028961, Compound 180::US10172864, Compound 180::US10946023, Compound 180	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280027	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280027&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817137	378161577							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617895	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C20H15F5N8/c21-19(22)6-4-12(9-19)29-18-32-16(14-2-1-3-15(30-14)20(23,24)25)31-17(33-18)28-11-5-7-27-13(8-11)10-26/h1-3,5,7-8,12H,4,6,9H2,(H2,27,28,29,31,32,33)	CPONOLJSMXHPCO-UHFFFAOYSA-N	280028	US10028961, Compound 181::US10172864, Compound 181::US10946023, Compound 181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280028	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280028&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799213	378161578							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617896	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccc(Cl)cc3C2)n1	InChI=1S/C23H20ClF5N6/c24-14-5-4-12-9-16(10-13(12)8-14)31-21-34-19(17-2-1-3-18(32-17)23(27,28)29)33-20(35-21)30-15-6-7-22(25,26)11-15/h1-5,8,15-16H,6-7,9-11H2,(H2,30,31,33,34,35)	XWCYRXFAEIUJMO-UHFFFAOYSA-N	280029	US10028961, Compound 182::US10172864, Compound 182::US10946023, Compound 182	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280029	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280029&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817114	378161579							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617897	FC(F)(F)c1csc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H21F7N6S/c20-17(21)5-1-10(2-6-17)27-15-30-13(14-29-12(9-33-14)19(24,25)26)31-16(32-15)28-11-3-7-18(22,23)8-4-11/h9-11H,1-8H2,(H2,27,28,30,31,32)	AKRQSKYNRTUAQA-UHFFFAOYSA-N	280030	US10028961, Compound 183::US10172864, Compound 183::US10946023, Compound 183	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280030&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817122	378161580							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617898	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C21H18F5N9/c22-20(23)4-1-13(10-20)30-17-31-16(29-12-2-7-28-15(9-12)19(11-27)5-6-19)32-18(33-17)35-8-3-14(34-35)21(24,25)26/h2-3,7-9,13H,1,4-6,10H2,(H2,28,29,30,31,32,33)	WFGLMCWPQJGAJJ-UHFFFAOYSA-N	280032	US10028961, Compound 185::US10172864, Compound 185::US10946023, Compound 185	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280032	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280032&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799291	378161582							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617899	FC(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H23F6N7/c21-15(22)13-9-27-10-14(30-13)16-31-17(28-11-1-5-19(23,24)6-2-11)33-18(32-16)29-12-3-7-20(25,26)8-4-12/h9-12,15H,1-8H2,(H2,28,29,31,32,33)	NNVCNVORYXXOAM-UHFFFAOYSA-N	280033	US10028961, Compound 186::US10172864, Compound 186::US10946023, Compound 186	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280033	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280033&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817121	378161583							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617900	CC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C18H18F6N6/c1-16(19,20)12-4-2-3-11(27-12)13-28-14(25-9-5-17(21,22)6-9)30-15(29-13)26-10-7-18(23,24)8-10/h2-4,9-10H,5-8H2,1H3,(H2,25,26,28,29,30)	YRSZQQILDIHZRT-UHFFFAOYSA-N	280034	US10028961, Compound 187::US10172864, Compound 187::US10946023, Compound 187	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280034	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280034&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817115	378161584							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617901	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C24H21F5N8/c1-30-22(10-11-22)18-13-15(7-12-31-18)33-21-36-19(16-3-2-4-17(34-16)24(27,28)29)35-20(37-21)32-14-5-8-23(25,26)9-6-14/h2-4,7,12-14H,5-6,8-11H2,(H2,31,32,33,35,36,37)	RLVMMYRYFBQTDM-UHFFFAOYSA-N	280036	US10028961, Compound 189::US10172864, Compound 189	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280036	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280036&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123396437	378161586							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617903	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C19H13F8N7/c20-17(21)7-10(8-17)30-16-33-14(11-2-1-3-12(31-11)18(22,23)24)32-15(34-16)29-9-4-5-28-13(6-9)19(25,26)27/h1-6,10H,7-8H2,(H2,28,29,30,32,33,34)	VURZKJCJGOOOFL-UHFFFAOYSA-N	280037	US10028961, Compound 190::US10172864, Compound 190::US10946023, Compound 190	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280037	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280037&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817505	378161587							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617905	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C21H21F7N6/c22-19(23)5-4-11(8-19)29-16-32-15(13-2-1-3-14(31-13)21(26,27)28)33-17(34-16)30-12-6-18(7-12)9-20(24,25)10-18/h1-3,11-12H,4-10H2,(H2,29,30,32,33,34)	RHCDZLRZYCRNDX-UHFFFAOYSA-N	280038	US10028961, Compound 191::US10172864, Compound 191::US10946023, Compound 191	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280038	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280038&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817431	378161588							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617906	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C21H17F8N7/c22-19(23)7-4-11(5-8-19)31-17-34-16(13-2-1-3-14(33-13)20(24,25)26)35-18(36-17)32-12-6-9-30-15(10-12)21(27,28)29/h1-3,6,9-11H,4-5,7-8H2,(H2,30,31,32,34,35,36)	ODBLPFGHFKRKHG-UHFFFAOYSA-N	280039	US10028961, Compound 192::US10172864, Compound 192::US10946023, Compound 192	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280039	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280039&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798913	378161589							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617907	C[C@@H](Nc1nc(NC(C2CC2)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C21H25F3N6/c1-11(12-5-6-12)25-19-28-18(15-3-2-4-16(26-15)21(22,23)24)29-20(30-19)27-17(13-7-8-13)14-9-10-14/h2-4,11-14,17H,5-10H2,1H3,(H2,25,27,28,29,30)	IEWNKIUGPADRRO-UHFFFAOYSA-N	280040	US10028961, Compound 193::US10172864, Compound 193::US10946023, Compound 193	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280040	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280040&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817507	378161590							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617909	FC(F)(F)c1nccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H18F7N7/c19-16(20)4-1-9(7-16)27-14-30-12(11-3-6-26-13(29-11)18(23,24)25)31-15(32-14)28-10-2-5-17(21,22)8-10/h3,6,9-10H,1-2,4-5,7-8H2,(H2,27,28,30,31,32)	VWUHSVAZJFWQPW-UHFFFAOYSA-N	280041	US10028961, Compound 194::US10172864, Compound 194::US10946023, Compound 194	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280041	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280041&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817504	378161591							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617910	Fc1cc(F)cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2nc(F)ccc2F)c1	InChI=1S/C18H12F6N6/c19-8-3-9(20)5-10(4-8)25-16-28-15(14-12(21)1-2-13(22)27-14)29-17(30-16)26-11-6-18(23,24)7-11/h1-5,11H,6-7H2,(H2,25,26,28,29,30)	YOKUNNSAZUOEON-UHFFFAOYSA-N	280042	US10028961, Compound 195::US10172864, Compound 195::US10946023, Compound 195	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280042	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280042&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798724	378161592							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617911	CC[C@@H](Nc1nc(N[C@@H](CC)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r|	InChI=1S/C16H17ClF6N6/c1-3-9(15(18,19)20)25-13-27-12(8-6-5-7-11(17)24-8)28-14(29-13)26-10(4-2)16(21,22)23/h5-7,9-10H,3-4H2,1-2H3,(H2,25,26,27,28,29)	SDUBFPITPDQUSW-UHFFFAOYSA-N	280043	US10028961, Compound 196::US10172864, Compound 196::US10946023, Compound 196	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280043	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280043&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817506	378161593							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617912	FC(F)(F)c1ccn(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C17H12F8N8/c18-15(19)6-9(7-15)28-13-29-12(27-8-1-3-26-11(5-8)17(23,24)25)30-14(31-13)33-4-2-10(32-33)16(20,21)22/h1-5,9H,6-7H2,(H2,26,27,28,29,30,31)	GIXRLAOMSYYYTD-UHFFFAOYSA-N	280044	US10028961, Compound 197::US10172864, Compound 197::US10946023, Compound 197	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280044	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280044&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798951	378161594							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617913	Fc1ccc(cc1)[C@@H]1C[C@@H](C1)Nc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F |r,wU:9.12,7.7,(9.46,.32,;8.13,-.45,;8.13,-1.99,;6.8,-2.76,;5.46,-1.99,;5.46,-.45,;6.8,.32,;4.13,-2.76,;2.64,-2.36,;2.24,-3.85,;3.73,-4.25,;.91,-4.62,;-.43,-3.85,;-1.76,-4.62,;-3.09,-3.85,;-4.43,-4.62,;-5.76,-3.85,;-5.76,-2.31,;-7.22,-1.83,;-8.13,-3.08,;-9.46,-2.31,;-9.46,-3.85,;-7.22,-4.33,;-3.09,-2.31,;-1.76,-1.54,;-.43,-2.31,;-1.76,,;-3.09,.77,;-3.09,2.31,;-1.76,3.08,;-.43,2.31,;-.43,.77,;.91,3.08,;2.24,2.31,;.91,4.62,;2.24,3.85,)|	InChI=1S/C24H22F6N6/c25-15-6-4-13(5-7-15)14-10-17(11-14)32-22-35-20(18-2-1-3-19(33-18)24(28,29)30)34-21(36-22)31-16-8-9-23(26,27)12-16/h1-7,14,16-17H,8-12H2,(H2,31,32,34,35,36)	MVZVTAYGMMCXIJ-UHFFFAOYSA-N	280046	US10028961, Compound 199::US10172864, Compound 199::US10946023, Compound 199	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280046	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280046&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817184	378161596							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617914	FC(F)(F)c1cc(Nc2nc(NCC3CC3)nc(n2)-c2cccc(Cl)n2)ccn1	InChI=1S/C18H15ClF3N7/c19-14-3-1-2-12(26-14)15-27-16(24-9-10-4-5-10)29-17(28-15)25-11-6-7-23-13(8-11)18(20,21)22/h1-3,6-8,10H,4-5,9H2,(H2,23,24,25,27,28,29)	ZMPPKTRRHWZFFR-UHFFFAOYSA-N	280047	US10028961, Compound 200::US10172864, Compound 200::US10946023, Compound 200	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280047	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280047&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798795	378161597							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617915	CC(Nc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C19H15F6N9/c1-10(18(20,21)22)28-14-30-15(29-11-3-7-27-13(9-11)17(26-2)5-6-17)32-16(31-14)34-8-4-12(33-34)19(23,24)25/h3-4,7-10H,5-6H2,1H3,(H2,27,28,29,30,31,32)	OQCGRHOQNOOHFP-UHFFFAOYSA-N	280048	US10028961, Compound 201::US10172864, Compound 201	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280048	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280048&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124000502	378161598							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617916	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)-c2ccccc2)n1	InChI=1S/C25H20F5N7/c26-24(27)11-9-17(14-24)33-23-36-21(18-7-4-8-20(34-18)25(28,29)30)35-22(37-23)32-16-10-12-31-19(13-16)15-5-2-1-3-6-15/h1-8,10,12-13,17H,9,11,14H2,(H2,31,32,33,35,36,37)	WBCWQBKLLSFRCG-UHFFFAOYSA-N	280049	US10028961, Compound 202::US10172864, Compound 202::US10946023, Compound 202	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280049	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280049&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798716	378161599							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617917	C[C@@H](Nc1nc(NC(C)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C17H18F6N6/c1-8(10-6-7-10)24-14-27-13(11-4-3-5-12(26-11)17(21,22)23)28-15(29-14)25-9(2)16(18,19)20/h3-5,8-10H,6-7H2,1-2H3,(H2,24,25,27,28,29)	AFJDSJYOWKPURG-UHFFFAOYSA-N	280050	US10028961, Compound 203::US10172864, Compound 203::US10946023, Compound 203	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280050	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280050&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817231	378161600							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617919	FC(F)c1csc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H22F6N6S/c20-13(21)12-9-32-15(28-12)14-29-16(26-10-1-5-18(22,23)6-2-10)31-17(30-14)27-11-3-7-19(24,25)8-4-11/h9-11,13H,1-8H2,(H2,26,27,29,30,31)	KXYSDNWDMNWMPI-UHFFFAOYSA-N	280052	US10028961, Compound 205::US10172864, Compound 205::US10946023, Compound 205	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280052	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280052&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817472	378161602							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617920	C[C@@H](Nc1nc(Nc2ccnc(c2)C#N)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C16H11F6N9/c1-8(15(17,18)19)25-12-27-13(26-9-2-4-24-10(6-9)7-23)29-14(28-12)31-5-3-11(30-31)16(20,21)22/h2-6,8H,1H3,(H2,24,25,26,27,28,29)	WPINTHZUZYAPQF-UHFFFAOYSA-N	280054	US10028961, Compound 207::US10172864, Compound 207::US10946023, Compound 207	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280054	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280054&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817469	378161604							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617921	CC(F)(F)c1nc(cs1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H16F6N6S/c1-14(17,18)11-25-9(6-29-11)10-26-12(23-7-2-15(19,20)3-7)28-13(27-10)24-8-4-16(21,22)5-8/h6-8H,2-5H2,1H3,(H2,23,24,26,27,28)	RGHZRMLVPJRYFM-UHFFFAOYSA-N	280056	US10028961, Compound 209::US10172864, Compound 209::US10946023, Compound 209	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280056	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280056&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817148	378161606							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617922	FC(F)(F)c1ccn(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C17H12F5N9/c18-16(19)6-11(7-16)26-14-27-13(25-9-1-3-24-10(5-9)8-23)28-15(29-14)31-4-2-12(30-31)17(20,21)22/h1-5,11H,6-7H2,(H2,24,25,26,27,28,29)	UDPIYDLIPGHOFT-UHFFFAOYSA-N	280057	US10028961, Compound 210::US10172864, Compound 210::US10946023, Compound 210	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280057	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280057&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799025	378161607							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617923	CC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C25H24F4N8/c1-23(26,27)18-4-2-3-17(34-18)20-35-21(32-15-5-8-25(28,29)9-6-15)37-22(36-20)33-16-7-12-31-19(13-16)24(14-30)10-11-24/h2-4,7,12-13,15H,5-6,8-11H2,1H3,(H2,31,32,33,35,36,37)	QRMZPBWPZWIROS-UHFFFAOYSA-N	280058	US10028961, Compound 211::US10172864, Compound 211::US10946023, Compound 211	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280058	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280058&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817159	378161608							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617924	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(Cl)n1	InChI=1S/C20H23ClF4N6/c21-15-3-1-2-14(28-15)16-29-17(26-12-4-8-19(22,23)9-5-12)31-18(30-16)27-13-6-10-20(24,25)11-7-13/h1-3,12-13H,4-11H2,(H2,26,27,29,30,31)	UIBBMCJNFUASJY-UHFFFAOYSA-N	280059	US10028961, Compound 212::US10172864, Compound 212::US10946023, Compound 212	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280059	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280059&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817149	378161609							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617925	FC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1	InChI=1S/C19H13F5N8/c20-18(21)7-12(8-18)28-17-31-15(13-2-1-3-14(29-13)19(22,23)24)30-16(32-17)27-10-4-5-26-11(6-10)9-25/h1-6,12H,7-8H2,(H2,26,27,28,30,31,32)	RQRJJSVAJSUINU-UHFFFAOYSA-N	280060	US10028961, Compound 213::US10172864, Compound 213::US10946023, Compound 213	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280060	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280060&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817155	378161610							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617926	CC(CC#N)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C18H20F3N7/c1-10(8-9-22)23-16-26-15(13-4-3-5-14(25-13)18(19,20)21)27-17(28-16)24-11(2)12-6-7-12/h3-5,10-12H,6-8H2,1-2H3,(H2,23,24,26,27,28)	IFMDZJNJPFFCSK-UHFFFAOYSA-N	280061	US10028961, Compound 214::US10172864, Compound 214::US10946023, Compound 214	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280061	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280061&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799309	378161611							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617927	FC(F)(F)CNc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-c1cccc(Cl)n1	InChI=1S/C19H14ClF3N8/c1-24-18(6-7-18)13-9-11(5-8-25-13)27-17-30-15(12-3-2-4-14(20)28-12)29-16(31-17)26-10-19(21,22)23/h2-5,8-9H,6-7,10H2,(H2,25,26,27,29,30,31)	RJYPNTZBJZUSPV-UHFFFAOYSA-N	280062	US10028961, Compound 215::US10172864, Compound 215	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280062	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280062&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124015477	378161612							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617928	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC(F)(F)C2)nc(NCC2CC(F)(F)C2)n1	InChI=1S/C19H19F7N6/c20-17(21)4-10(5-17)8-27-15-30-14(12-2-1-3-13(29-12)19(24,25)26)31-16(32-15)28-9-11-6-18(22,23)7-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	OSLHWFZOOADJCB-UHFFFAOYSA-N	280063	US10028961, Compound 216::US10172864, Compound 216::US10946023, Compound 216	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280063	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280063&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817178	378161613							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617929	CC(Nc1nc(Nc2ccnc(c2)-c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F	InChI=1S/C23H17F6N7/c1-13(22(24,25)26)31-20-34-19(16-8-5-9-18(33-16)23(27,28)29)35-21(36-20)32-15-10-11-30-17(12-15)14-6-3-2-4-7-14/h2-13H,1H3,(H2,30,31,32,34,35,36)	NWTISIXHXPIMSM-UHFFFAOYSA-N	280064	US10028961, Compound 217::US10172864, Compound 217::US10946023, Compound 217	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280064	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280064&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817152	378161614							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617930	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)-c2ccccc2)n1	InChI=1S/C26H22F5N7/c27-25(28)12-9-17(10-13-25)33-23-36-22(19-7-4-8-21(35-19)26(29,30)31)37-24(38-23)34-18-11-14-32-20(15-18)16-5-2-1-3-6-16/h1-8,11,14-15,17H,9-10,12-13H2,(H2,32,33,34,36,37,38)	WTQROKONFNCZLX-UHFFFAOYSA-N	280067	US10028961, Compound 220::US10172864, Compound 220::US10946023, Compound 220	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280067	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280067&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798796	378161617							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617931	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H15F8N7/c21-18(22)7-10(8-18)9-30-16-33-15(12-2-1-3-13(32-12)19(23,24)25)34-17(35-16)31-11-4-5-29-14(6-11)20(26,27)28/h1-6,10H,7-9H2,(H2,29,30,31,33,34,35)	OWAVUCAENWNGFB-UHFFFAOYSA-N	280068	US10028961, Compound 221::US10172864, Compound 221::US10946023, Compound 221	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280068	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280068&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799308	378161618							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617932	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)c2ccccn2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C23H23F5N8/c24-22(25)9-7-14(12-22)30-20-33-19(16-4-3-5-17(32-16)23(26,27)28)34-21(35-20)31-15-8-11-36(13-15)18-6-1-2-10-29-18/h1-6,10,14-15H,7-9,11-13H2,(H2,30,31,33,34,35)	TYLCUGJKUXBFOZ-UHFFFAOYSA-N	280069	US10028961, Compound 222::US10172864, Compound 222::US10946023, Compound 222	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280069	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280069&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817038	378161619							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617933	FC(F)(F)c1nc(cs1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H21F7N6S/c20-17(21)5-1-10(2-6-17)27-15-30-13(12-9-33-14(29-12)19(24,25)26)31-16(32-15)28-11-3-7-18(22,23)8-4-11/h9-11H,1-8H2,(H2,27,28,30,31,32)	PFTFOLWIPCINKJ-UHFFFAOYSA-N	280070	US10028961, Compound 223::US10172864, Compound 223::US10946023, Compound 223	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280070	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280070&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817026	378161620							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617934	FC(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H24F6N6/c22-16(23)14-2-1-3-15(30-14)17-31-18(28-12-4-8-20(24,25)9-5-12)33-19(32-17)29-13-6-10-21(26,27)11-7-13/h1-3,12-13,16H,4-11H2,(H2,28,29,31,32,33)	VPZNRBLRTQODKB-UHFFFAOYSA-N	280071	US10028961, Compound 224::US10172864, Compound 224::US10946023, Compound 224	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280071	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280071&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817029	378161621							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617935	FC(F)(F)CNc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H14F6N8/c1-27-18(6-7-18)14-9-11(5-8-28-14)30-17-33-15(32-16(34-17)29-10-19(21,22)23)12-3-2-4-13(31-12)20(24,25)26/h2-5,8-9H,6-7,10H2,(H2,28,29,30,32,33,34)	PFZLERVPZNDZDD-UHFFFAOYSA-N	280073	US10028961, Compound 226::US10172864, Compound 226	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280073	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280073&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123942898	378161623							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617936	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)c2ncccn2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C22H22F5N9/c23-21(24)7-5-13(11-21)30-18-33-17(15-3-1-4-16(32-15)22(25,26)27)34-19(35-18)31-14-6-10-36(12-14)20-28-8-2-9-29-20/h1-4,8-9,13-14H,5-7,10-12H2,(H2,30,31,33,34,35)	YPXQHURHYKDPKF-UHFFFAOYSA-N	280074	US10028961, Compound 227::US10172864, Compound 227::US10946023, Compound 227	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280074	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280074&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817030	378161624							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617937	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C25H21F5N8/c1-31-23(6-7-23)18-9-14(5-8-32-18)33-20-36-19(16-3-2-4-17(35-16)25(28,29)30)37-21(38-20)34-15-10-22(11-15)12-24(26,27)13-22/h2-5,8-9,15H,6-7,10-13H2,(H2,32,33,34,36,37,38)	QOYBVQHDVXHECC-UHFFFAOYSA-N	280076	US10028961, Compound 229::US10172864, Compound 229	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280076	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280076&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123245946	378161626							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617938	CC(C)(CC#N)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C21H19F5N8/c1-19(2,8-9-27)34-18-32-16(13-5-4-6-14(30-13)21(24,25)26)31-17(33-18)29-12-7-10-28-15(11-12)20(3,22)23/h4-7,10-11H,8H2,1-3H3,(H2,28,29,31,32,33,34)	BFTBMPMZGISYIU-UHFFFAOYSA-N	280078	US10028961, Compound 231::US10172864, Compound 231::US10946023, Compound 231	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280078	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280078&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117800590	378161628							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617939	FC(F)(F)CNc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C17H10F9N7/c18-15(19,20)7-28-13-31-12(9-2-1-3-10(30-9)16(21,22)23)32-14(33-13)29-8-4-5-27-11(6-8)17(24,25)26/h1-6H,7H2,(H2,27,28,29,31,32,33)	PLCJHAPDBYLXRZ-UHFFFAOYSA-N	280079	US10028961, Compound 232::US10172864, Compound 232::US10946023, Compound 232	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280079	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280079&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817637	378161629							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617940	C[C@@H](Nc1nc(NC2C3CC4CC(C3)CC2C4)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r,wU:1.0,TLB:6:7:9:12.11.13,THB:14:15:9:12.11.13,14:12:9:7.15.16,11:12:7:9.10.16,(-4.39,-1.54,;-4.39,-3.08,;-3.05,-3.85,;-1.72,-3.08,;-.38,-3.85,;.95,-3.08,;2.28,-3.85,;3.62,-3.08,;4.95,-3.85,;6.28,-3.08,;6.28,-1.54,;7.26,-.81,;5.72,-.81,;4.95,-2.6,;4.55,.03,;3.62,-1.54,;4.95,-.77,;.95,-1.54,;-.38,-.77,;-1.72,-1.54,;-.38,.77,;-1.72,1.54,;-1.72,3.08,;-.38,3.85,;1,3.11,;.95,1.54,;2.33,3.88,;3.66,4.65,;3.1,2.54,;1.56,5.21,;-5.72,-3.85,;-7.26,-3.85,;-6.49,-5.18,)|			280081	US10028961, Compound 234::US10172864, Compound 234::US10946023, Compound 234	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280081	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280081&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			122440897	378161631							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617942	CC(C)(O)CNc1nc(Nc2cc(F)cc(Cl)c2)nc(n1)-c1cccc(n1)C(C)(F)F	InChI=1S/C20H20ClF3N6O/c1-19(2,31)10-25-17-28-16(14-5-4-6-15(27-14)20(3,23)24)29-18(30-17)26-13-8-11(21)7-12(22)9-13/h4-9,31H,10H2,1-3H3,(H2,25,26,28,29,30)	OCYNITMCPHUSLK-UHFFFAOYSA-N	280083	US10028961, Compound 236::US10172864, Compound 236::US10946023, Compound 236	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280083	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280083&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817133	378161633							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617943	FC(F)(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H18F7N7/c19-16(20)4-1-9(7-16)27-14-30-13(12-26-6-3-11(29-12)18(23,24)25)31-15(32-14)28-10-2-5-17(21,22)8-10/h3,6,9-10H,1-2,4-5,7-8H2,(H2,27,28,30,31,32)	KWUXKJRKEMYSCZ-UHFFFAOYSA-N	280084	US10028961, Compound 237::US10172864, Compound 237::US10946023, Compound 237	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280084	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280084&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817165	378161634							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617944	FC(F)(F)c1cccc(n1)-c1nc(NC2CN(C2)c2ccccn2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C22H21F5N8/c23-21(24)8-7-13(10-21)29-19-32-18(15-4-3-5-16(31-15)22(25,26)27)33-20(34-19)30-14-11-35(12-14)17-6-1-2-9-28-17/h1-6,9,13-14H,7-8,10-12H2,(H2,29,30,32,33,34)	ZBGLZSWJEQJJBZ-UHFFFAOYSA-N	280085	US10028961, Compound 238::US10172864, Compound 238::US10946023, Compound 238	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280085	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280085&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817186	378161635							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617945	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(N[C@@H]2CN(C(=O)C2)c2ccccn2)n1 |r|	InChI=1S/C23H21F5N8O/c24-22(25)8-7-13(11-22)30-20-33-19(15-4-3-5-16(32-15)23(26,27)28)34-21(35-20)31-14-10-18(37)36(12-14)17-6-1-2-9-29-17/h1-6,9,13-14H,7-8,10-12H2,(H2,30,31,33,34,35)	JXQUUPVCXHTUAY-UHFFFAOYSA-N	280086	US10028961, Compound 239::US10172864, Compound 239::US10946023, Compound 239	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280086	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280086&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817437	378161636							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617946	CC(C)OCC(C)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|	InChI=1S/C20H27F3N6O/c1-11(2)30-10-12(3)24-18-27-17(15-6-5-7-16(26-15)20(21,22)23)28-19(29-18)25-13(4)14-8-9-14/h5-7,11-14H,8-10H2,1-4H3,(H2,24,25,27,28,29)	HNZFJEZPGBZOCO-UHFFFAOYSA-N	280088	US10028961, Compound 241::US10172864, Compound 241::US10946023, Compound 241	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280088	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280088&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817568	378161638							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617948	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2Cc3ccc(cc3C2)C#N)n1	InChI=1S/C24H20F5N7/c25-23(26)7-6-16(11-23)31-21-34-20(18-2-1-3-19(33-18)24(27,28)29)35-22(36-21)32-17-9-14-5-4-13(12-30)8-15(14)10-17/h1-5,8,16-17H,6-7,9-11H2,(H2,31,32,34,35,36)	TXAOJZZVXLZXJJ-UHFFFAOYSA-N	280089	US10028961, Compound 242::US10172864, Compound 242::US10946023, Compound 242	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280089	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280089&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817436	378161639							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617949	FC(F)(F)c1cccc(n1)-c1nc(NC2CN(C2)c2cccnc2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C22H21F5N8/c23-21(24)7-6-13(9-21)29-19-32-18(16-4-1-5-17(31-16)22(25,26)27)33-20(34-19)30-14-11-35(12-14)15-3-2-8-28-10-15/h1-5,8,10,13-14H,6-7,9,11-12H2,(H2,29,30,32,33,34)	MOFOELJBPOCBKQ-UHFFFAOYSA-N	280090	US10028961, Compound 243::US10172864, Compound 243::US10946023, Compound 243	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280090	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280090&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817396	378161640							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617952	C[C@@H](Nc1nc(NCCOc2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C22H23F3N6O/c1-14(15-10-11-15)27-21-30-19(17-8-5-9-18(28-17)22(23,24)25)29-20(31-21)26-12-13-32-16-6-3-2-4-7-16/h2-9,14-15H,10-13H2,1H3,(H2,26,27,29,30,31)	YVNVAIVKELSNHE-UHFFFAOYSA-N	280093	US10028961, Compound 246::US10172864, Compound 246::US10946023, Compound 246	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280093	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280093&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817294	378161643							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617954	CC(C)(Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C20H17F5N8/c1-18(2,10-26)33-17-31-15(12-5-4-6-13(29-12)20(23,24)25)30-16(32-17)28-11-7-8-27-14(9-11)19(3,21)22/h4-9H,1-3H3,(H2,27,28,30,31,32,33)	BDJHMJRZDMMMSY-UHFFFAOYSA-N	280094	US10028961, Compound 247::US10172864, Compound 247::US10946023, Compound 247	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280094	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280094&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799111	378161644							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617956	Nc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H24F5N7/c21-13-1-2-14(26)29-15(13)16-30-17(27-11-3-7-19(22,23)8-4-11)32-18(31-16)28-12-5-9-20(24,25)10-6-12/h1-2,11-12H,3-10H2,(H2,26,29)(H2,27,28,30,31,32)	AHCWVZUQCYWTLX-UHFFFAOYSA-N	280096	US10028961, Compound 249::US10172864, Compound 249::US10946023, Compound 249	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280096	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280096&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799328	378161646							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617957	CC(CC#N)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C20H17F5N8/c1-11(6-8-26)28-17-31-16(13-4-3-5-14(30-13)20(23,24)25)32-18(33-17)29-12-7-9-27-15(10-12)19(2,21)22/h3-5,7,9-11H,6H2,1-2H3,(H2,27,28,29,31,32,33)	KFKFZAMDAKZTOH-UHFFFAOYSA-N	280097	US10028961, Compound 250::US10172864, Compound 250::US10946023, Compound 250	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280097	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280097&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117800753	378161647							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617959	FC(F)(F)c1nccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H14F7N7/c17-14(18)3-7(4-14)25-12-28-10(9-1-2-24-11(27-9)16(21,22)23)29-13(30-12)26-8-5-15(19,20)6-8/h1-2,7-8H,3-6H2,(H2,25,26,28,29,30)	YXRZGIVPZUGDBI-UHFFFAOYSA-N	280098	US10028961, Compound 251::US10172864, Compound 251::US10946023, Compound 251	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280098	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280098&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817045	378161648							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617960	FC(F)(F)Oc1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C19H19F7N6O/c20-17(21)6-4-10(8-17)27-15-30-14(12-2-1-3-13(29-12)33-19(24,25)26)31-16(32-15)28-11-5-7-18(22,23)9-11/h1-3,10-11H,4-9H2,(H2,27,28,30,31,32)	MQELCCGCZSQGHW-UHFFFAOYSA-N	280099	US10028961, Compound 252::US10172864, Compound 252::US10946023, Compound 252	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280099	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280099&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817037	378161649							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617961	CC(Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C19H15F5N8/c1-10(9-25)27-16-30-15(12-4-3-5-13(29-12)19(22,23)24)31-17(32-16)28-11-6-7-26-14(8-11)18(2,20)21/h3-8,10H,1-2H3,(H2,26,27,28,30,31,32)	DOYNKYWVGHFSIP-UHFFFAOYSA-N	280100	US10028961, Compound 253::US10172864, Compound 253::US10946023, Compound 253	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280100	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280100&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799196	378161650							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617962	FC(F)(F)c1cccc(n1)-c1nc(NC2CCOCC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H23F5N6O/c21-19(22)8-4-12(5-9-19)26-17-29-16(14-2-1-3-15(28-14)20(23,24)25)30-18(31-17)27-13-6-10-32-11-7-13/h1-3,12-13H,4-11H2,(H2,26,27,29,30,31)	XOGJBAWBFBEDJT-UHFFFAOYSA-N	280102	US10028961, Compound 255::US10172864, Compound 255::US10946023, Compound 255	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280102	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280102&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817036	378161652							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617964	FC(F)(F)c1ccnc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H14F7N7/c17-14(18)3-7(4-14)25-12-28-11(10-24-2-1-9(27-10)16(21,22)23)29-13(30-12)26-8-5-15(19,20)6-8/h1-2,7-8H,3-6H2,(H2,25,26,28,29,30)	FPHDGFLOXFTVGJ-UHFFFAOYSA-N	280103	US10028961, Compound 256::US10172864, Compound 256::US10946023, Compound 256	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280103	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280103&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817034	378161653							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617965	FC(F)(F)c1cccc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C22H17F8N7/c23-20(24)9-19(10-20)7-12(8-19)33-18-36-16(13-2-1-3-14(34-13)21(25,26)27)35-17(37-18)32-11-4-5-31-15(6-11)22(28,29)30/h1-6,12H,7-10H2,(H2,31,32,33,35,36,37)	BTPLBROFKCBOEI-UHFFFAOYSA-N	280104	US10028961, Compound 257::US10172864, Compound 257::US10946023, Compound 257	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280104	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280104&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799484	378161654							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617966	FC(F)(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C22H18F5N9/c23-21(24)4-1-13(10-21)32-19-35-17(16-30-8-3-14(33-16)22(25,26)27)34-18(36-19)31-12-2-7-29-15(9-12)20(11-28)5-6-20/h2-3,7-9,13H,1,4-6,10H2,(H2,29,31,32,34,35,36)	NQLUCGNQWCNNAV-UHFFFAOYSA-N	280108	US10028961, Compound 261::US10172864, Compound 261::US10946023, Compound 261	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280108	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280108&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799322	378161658							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617967	C[C@@H](Nc1nc(NCC(C)(C)C#N)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C19H22F3N7/c1-11(12-7-8-12)25-17-28-15(13-5-4-6-14(26-13)19(20,21)22)27-16(29-17)24-10-18(2,3)9-23/h4-6,11-12H,7-8,10H2,1-3H3,(H2,24,25,27,28,29)	YMYMOIAVHSSRHV-UHFFFAOYSA-N	280109	US10028961, Compound 262::US10172864, Compound 262::US10946023, Compound 262	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280109	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280109&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817189	378161659							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617969	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(C2)C(=O)c2ccccc2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C25H24F5N7O/c26-24(27)11-9-16(13-24)31-22-34-20(18-7-4-8-19(33-18)25(28,29)30)35-23(36-22)32-17-10-12-37(14-17)21(38)15-5-2-1-3-6-15/h1-8,16-17H,9-14H2,(H2,31,32,34,35,36)	IGICKZPCOKPPMZ-UHFFFAOYSA-N	280110	US10028961, Compound 263::US10172864, Compound 263::US10946023, Compound 263	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280110	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280110&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817170	378161660							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617971	CC(C)(O)CNc1nc(NC2CCC(F)(F)C2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C18H21F5N6O/c1-16(2,30)9-24-14-27-13(11-4-3-5-12(26-11)18(21,22)23)28-15(29-14)25-10-6-7-17(19,20)8-10/h3-5,10,30H,6-9H2,1-2H3,(H2,24,25,27,28,29)	BBXPSOCEABWQQG-UHFFFAOYSA-N	280111	US10028961, Compound 264::US10172864, Compound 264::US10946023, Compound 264	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280111	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280111&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817169	378161661							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617972	FC1(F)CC2(CC(C2)Nc2nc(NC3CC4(C3)CC(F)(F)C4)nc(n2)-c2cccc(Cl)n2)C1	InChI=1S/C22H23ClF4N6/c23-15-3-1-2-14(30-15)16-31-17(28-12-4-19(5-12)8-21(24,25)9-19)33-18(32-16)29-13-6-20(7-13)10-22(26,27)11-20/h1-3,12-13H,4-11H2,(H2,28,29,31,32,33)	PBFHHOMGSNGWEC-UHFFFAOYSA-N	280112	US10028961, Compound 265::US10172864, Compound 265::US10946023, Compound 265	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280112	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280112&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817162	378161662							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617974	CS(=O)(=O)N1CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C21H26F5N7O2S/c1-36(34,35)33-11-7-14(8-12-33)28-19-31-17(15-3-2-4-16(29-15)21(24,25)26)30-18(32-19)27-13-5-9-20(22,23)10-6-13/h2-4,13-14H,5-12H2,1H3,(H2,27,28,30,31,32)	XMCNRFYMKPJZQG-UHFFFAOYSA-N	280113	US10028961, Compound 266::US10172864, Compound 266::US10946023, Compound 266	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280113	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280113&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817164	378161663							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617976	CC(C)(CNc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C#N	InChI=1S/C21H19F5N8/c1-19(2,10-27)11-29-17-32-16(13-5-4-6-14(31-13)21(24,25)26)33-18(34-17)30-12-7-8-28-15(9-12)20(3,22)23/h4-9H,11H2,1-3H3,(H2,28,29,30,32,33,34)	LWUOICMGVABMMB-UHFFFAOYSA-N	280114	US10028961, Compound 267::US10172864, Compound 267::US10946023, Compound 267	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280114	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280114&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117800203	378161664							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617978	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1nccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C18H22F3N7/c1-9(11-3-4-11)23-16-26-15(14-22-8-7-13(25-14)18(19,20)21)27-17(28-16)24-10(2)12-5-6-12/h7-12H,3-6H2,1-2H3,(H2,23,24,26,27,28)	DDVPWDBXRXZEBC-UHFFFAOYSA-N	280115	US10028961, Compound 268::US10172864, Compound 268::US10946023, Compound 268	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280115	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280115&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817172	378161665							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617980	FC(F)(F)c1nccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F7N7/c21-18(22)6-1-11(2-7-18)29-16-32-14(13-5-10-28-15(31-13)20(25,26)27)33-17(34-16)30-12-3-8-19(23,24)9-4-12/h5,10-12H,1-4,6-9H2,(H2,29,30,32,33,34)	VFDBHGHEXPAMBP-UHFFFAOYSA-N	280117	US10028961, Compound 270::US10172864, Compound 270::US10946023, Compound 270	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280117	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280117&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817589	378161667							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617981	CC(CC#N)Nc1nc(NC(C)C[N+]#[C-])nc(n1)-c1cccc(Cl)n1	InChI=1S/C16H17ClN8/c1-10(7-8-18)20-15-23-14(12-5-4-6-13(17)22-12)24-16(25-15)21-11(2)9-19-3/h4-6,10-11H,7,9H2,1-2H3,(H2,20,21,23,24,25)	DPKMJIDGQOHGGQ-UHFFFAOYSA-N	280118	US10028961, Compound 271::US10172864, Compound 271	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280118	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280118&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124023000	378161668							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617983	Fc1ccc(cc1)[C@@H]1C[C@@H](C1)Nc1nc(N[C@H]2C[C@H](C2)c2ccc(F)cc2)nc(n1)-c1cccc(n1)C(F)(F)F |r,wU:16.17,9.12,18.22,7.7,(11.22,.32,;9.89,-.45,;9.89,-1.99,;8.55,-2.76,;7.22,-1.99,;7.22,-.45,;8.55,.32,;5.89,-2.76,;4.4,-2.36,;4,-3.85,;5.49,-4.25,;2.67,-4.62,;1.33,-3.85,;,-4.62,;-1.33,-3.85,;-2.67,-4.62,;-4,-3.85,;-5.49,-4.25,;-5.89,-2.76,;-4.4,-2.36,;-7.22,-1.99,;-7.22,-.45,;-8.55,.32,;-9.89,-.45,;-11.22,.32,;-9.89,-1.99,;-8.55,-2.76,;-1.33,-2.31,;,-1.54,;1.33,-2.31,;;-1.33,.77,;-1.33,2.31,;,3.08,;1.33,2.31,;1.33,.77,;2.67,3.08,;2.67,4.62,;4,2.31,;4,3.85,)|	InChI=1S/C29H25F5N6/c30-20-8-4-16(5-9-20)18-12-22(13-18)35-27-38-26(24-2-1-3-25(37-24)29(32,33)34)39-28(40-27)36-23-14-19(15-23)17-6-10-21(31)11-7-17/h1-11,18-19,22-23H,12-15H2,(H2,35,36,38,39,40)	NMLSZZYWTRQLTB-UHFFFAOYSA-N	280119	US10028961, Compound 272::US10172864, Compound 272::US10946023, Compound 272	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280119	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280119&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817318	378161669							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617984	CC(=O)N1CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C22H26F5N7O/c1-13(35)34-11-7-15(8-12-34)29-20-32-18(16-3-2-4-17(30-16)22(25,26)27)31-19(33-20)28-14-5-9-21(23,24)10-6-14/h2-4,14-15H,5-12H2,1H3,(H2,28,29,31,32,33)	PVZIUYNREPTYEJ-UHFFFAOYSA-N	280120	US10028961, Compound 273::US10172864, Compound 273::US10946023, Compound 273	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280120	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280120&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817549	378161670							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617986	CC(C)(C)OC(=O)N1CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C25H32F5N7O2/c1-23(2,3)39-22(38)37-13-9-16(10-14-37)32-21-35-19(17-5-4-6-18(33-17)25(28,29)30)34-20(36-21)31-15-7-11-24(26,27)12-8-15/h4-6,15-16H,7-14H2,1-3H3,(H2,31,32,34,35,36)	MMAPFCIIBGUZQG-UHFFFAOYSA-N	280121	US10028961, Compound 274::US10172864, Compound 274::US10946023, Compound 274	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280121	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280121&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817557	378161671							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617988	Cn1cc(c(n1)C(F)(F)F)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H24F7N7/c1-34-10-13(14(33-34)20(25,26)27)15-30-16(28-11-2-6-18(21,22)7-3-11)32-17(31-15)29-12-4-8-19(23,24)9-5-12/h10-12H,2-9H2,1H3,(H2,28,29,30,31,32)	MZFAUIFIADPAFR-UHFFFAOYSA-N	280122	US10028961, Compound 275::US10172864, Compound 275::US10946023, Compound 275	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280122	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280122&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817548	378161672							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617989	Fc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F6N6/c21-13-1-2-14(22)29-15(13)16-30-17(27-11-3-7-19(23,24)8-4-11)32-18(31-16)28-12-5-9-20(25,26)10-6-12/h1-2,11-12H,3-10H2,(H2,27,28,30,31,32)	PKVKJUWOHXPGCE-UHFFFAOYSA-N	280123	US10028961, Compound 276::US10172864, Compound 276::US10946023, Compound 276	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280123	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280123&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799150	378161673							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617990	C[C@@H](Nc1nc(N[C@H](C)C2CC2)nc(n1)-n1cc(I)cn1)C1CC1 |r|	InChI=1S/C16H22IN7/c1-9(11-3-4-11)19-14-21-15(20-10(2)12-5-6-12)23-16(22-14)24-8-13(17)7-18-24/h7-12H,3-6H2,1-2H3,(H2,19,20,21,22,23)	XKHRDUPMIXLGTD-UHFFFAOYSA-N	280126	US10028961, Compound 279::US10172864, Compound 279::US10946023, Compound 279	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280126	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280126&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817477	378161676							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617991	FC(F)(F)c1cccc(n1)-c1nc(NC2CCN(Cc3ccccc3)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C25H26F5N7/c26-24(27)11-9-17(13-24)31-22-34-21(19-7-4-8-20(33-19)25(28,29)30)35-23(36-22)32-18-10-12-37(15-18)14-16-5-2-1-3-6-16/h1-8,17-18H,9-15H2,(H2,31,32,34,35,36)	UWVLIFBOSBPFON-UHFFFAOYSA-N	280127	US10028961, Compound 280::US10172864, Compound 280::US10946023, Compound 280	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280127	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280127&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817414	378161677							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617993	CC(F)(F)c1nc(cs1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H24F6N6S/c1-18(21,22)15-29-13(10-33-15)14-30-16(27-11-2-6-19(23,24)7-3-11)32-17(31-14)28-12-4-8-20(25,26)9-5-12/h10-12H,2-9H2,1H3,(H2,27,28,30,31,32)	BCVWBQGSHAGBJM-UHFFFAOYSA-N	280130	US10028961, Compound 283::US10172864, Compound 283::US10946023, Compound 283	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280130	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280130&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817484	378161680							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617994	CC(C)(O)CNc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1cccc(n1)C(F)(F)F	InChI=1S/C19H23F5N6O/c1-17(2,31)10-25-15-28-14(12-4-3-5-13(27-12)19(22,23)24)29-16(30-15)26-11-6-8-18(20,21)9-7-11/h3-5,11,31H,6-10H2,1-2H3,(H2,25,26,28,29,30)	IWJRYKAPBRKGLL-UHFFFAOYSA-N	280134	US10028961, Compound 287::US10172864, Compound 287::US10946023, Compound 287	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280134	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280134&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817444	378161684							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617995	CC(C)(C)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C19H19F5N8/c1-17(2,3)32-16-30-14(13-26-8-6-11(28-13)19(22,23)24)29-15(31-16)27-10-5-7-25-12(9-10)18(4,20)21/h5-9H,1-4H3,(H2,25,27,29,30,31,32)	VVDJVXUCSQFDNF-UHFFFAOYSA-N	280136	US10028961, Compound 289::US10172864, Compound 289::US10946023, Compound 289	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280136	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280136&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817459	378161686							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617997	FC(F)(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H22F7N7/c21-18(22)6-1-11(2-7-18)29-16-32-15(14-28-10-5-13(31-14)20(25,26)27)33-17(34-16)30-12-3-8-19(23,24)9-4-12/h5,10-12H,1-4,6-9H2,(H2,29,30,32,33,34)	MDCZNBIZILVZSF-UHFFFAOYSA-N	280140	US10028961, Compound 293::US10172864, Compound 293::US10946023, Compound 293	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280140	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280140&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817463	378161690							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617998	FC(F)(F)Oc1cccc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H23F7N6O/c22-19(23)8-4-12(5-9-19)29-17-32-16(14-2-1-3-15(31-14)35-21(26,27)28)33-18(34-17)30-13-6-10-20(24,25)11-7-13/h1-3,12-13H,4-11H2,(H2,29,30,32,33,34)	HSAOXCHGPDCXKT-UHFFFAOYSA-N	280143	US10028961, Compound 296::US10172864, Compound 296::US10946023, Compound 296	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280143	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280143&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817462	378161693							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
617999	FC(F)(F)c1n[nH]cc1-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H22F7N7/c20-17(21)5-1-10(2-6-17)28-15-30-14(12-9-27-33-13(12)19(24,25)26)31-16(32-15)29-11-3-7-18(22,23)8-4-11/h9-11H,1-8H2,(H,27,33)(H2,28,29,30,31,32)	WYHVNJNVMROQBY-UHFFFAOYSA-N	280144	US10028961, Compound 297::US10172864, Compound 297::US10946023, Compound 297	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280144	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280144&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817464	378161694							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618000	CC(C)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1nccc(n1)C(F)(F)F	InChI=1S/C18H17F5N8/c1-9(2)26-15-29-14(13-25-7-5-11(28-13)18(21,22)23)30-16(31-15)27-10-4-6-24-12(8-10)17(3,19)20/h4-9H,1-3H3,(H2,24,26,27,29,30,31)	MNWAUMZTPYXVGO-UHFFFAOYSA-N	280145	US10028961, Compound 298::US10172864, Compound 298::US10946023, Compound 298	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280145	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280145&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798710	378161695							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618002	Cc1nc(co1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H16F4N6O/c1-7-20-10(6-26-7)11-23-12(21-8-2-14(16,17)3-8)25-13(24-11)22-9-4-15(18,19)5-9/h6,8-9H,2-5H2,1H3,(H2,21,22,23,24,25)	YBHPSBQYBQRDEV-UHFFFAOYSA-N	280148	US10028961, Compound 301::US10172864, Compound 301::US10946023, Compound 301	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280148	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280148&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817319	378161698							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618003	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-n1cc(Cl)cn1	InChI=1S/C18H22ClF4N7/c19-11-9-24-30(10-11)16-28-14(25-12-1-5-17(20,21)6-2-12)27-15(29-16)26-13-3-7-18(22,23)8-4-13/h9-10,12-13H,1-8H2,(H2,25,26,27,28,29)	QSWMJNNVEMLNDB-UHFFFAOYSA-N	280149	US10028961, Compound 302::US10172864, Compound 302::US10946023, Compound 302	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280149	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280149&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817332	378161699							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618004	FC(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H23F6N7/c21-14(22)13-5-10-27-15(30-13)16-31-17(28-11-1-6-19(23,24)7-2-11)33-18(32-16)29-12-3-8-20(25,26)9-4-12/h5,10-12,14H,1-4,6-9H2,(H2,28,29,31,32,33)	KCKMAAKVFCQNEN-UHFFFAOYSA-N	280155	US10028961, Compound 308::US10172864, Compound 308::US10946023, Compound 308	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280155	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280155&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466270	378161705							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618005	Oc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H23F5N6O/c21-13-1-2-14(32)28-15(13)16-29-17(26-11-3-7-19(22,23)8-4-11)31-18(30-16)27-12-5-9-20(24,25)10-6-12/h1-2,11-12H,3-10H2,(H,28,32)(H2,26,27,29,30,31)	LBPUKFIAHANDDC-UHFFFAOYSA-N	280156	US10028961, Compound 309::US10172864, Compound 309::US10946023, Compound 309	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280156	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280156&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799124	378161706							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618006	Cc1cc(no1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H16F4N6O/c1-7-2-10(25-26-7)11-22-12(20-8-3-14(16,17)4-8)24-13(23-11)21-9-5-15(18,19)6-9/h2,8-9H,3-6H2,1H3,(H2,20,21,22,23,24)	JWLFPLOMUNYBLN-UHFFFAOYSA-N	280158	US10028961, Compound 311::US10172864, Compound 311::US10946023, Compound 311	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280158	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280158&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817411	378161708							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618007	COCCc1ccnc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C22H29F4N7O/c1-34-13-7-16-6-12-27-17(28-16)18-31-19(29-14-2-8-21(23,24)9-3-14)33-20(32-18)30-15-4-10-22(25,26)11-5-15/h6,12,14-15H,2-5,7-11,13H2,1H3,(H2,29,30,31,32,33)	IIDRMKULCOPTDM-UHFFFAOYSA-N	280162	US10028961, Compound 315::US10172864, Compound 315::US10946023, Compound 315	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280162	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280162&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90466269	378161712							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618008	Cc1nc(c[nH]1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H17F4N7/c1-7-20-6-10(21-7)11-24-12(22-8-2-14(16,17)3-8)26-13(25-11)23-9-4-15(18,19)5-9/h6,8-9H,2-5H2,1H3,(H,20,21)(H2,22,23,24,25,26)	LRORKNAAPJYJSX-UHFFFAOYSA-N	280164	US10028961, Compound 317::US10172864, Compound 317::US10946023, Compound 317	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280164	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280164&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817555	378161714							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618009	Cc1nc(c[nH]1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C17H21F4N7/c1-9-22-8-12(23-9)13-26-14(24-10-2-4-16(18,19)6-10)28-15(27-13)25-11-3-5-17(20,21)7-11/h8,10-11H,2-7H2,1H3,(H,22,23)(H2,24,25,26,27,28)	WXUIXALGZVQUGH-UHFFFAOYSA-N	280166	US10028961, Compound 319::US10172864, Compound 319::US10946023, Compound 319	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280166	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280166&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817325	378161716							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618010	COc1ccc(F)c(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H25F5N6O/c1-33-15-3-2-14(22)16(29-15)17-30-18(27-12-4-8-20(23,24)9-5-12)32-19(31-17)28-13-6-10-21(25,26)11-7-13/h2-3,12-13H,4-11H2,1H3,(H2,27,28,30,31,32)	PUYRUGBORWDDDV-UHFFFAOYSA-N	280168	US10028961, Compound 321::US10172864, Compound 321::US10946023, Compound 321	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280168	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280168&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817329	378161718							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618012	Cc1nsc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C18H23F4N7S/c1-10-23-14(30-29-10)13-26-15(24-11-2-6-17(19,20)7-3-11)28-16(27-13)25-12-4-8-18(21,22)9-5-12/h11-12H,2-9H2,1H3,(H2,24,25,26,27,28)	YGASMFPIDZFMKN-UHFFFAOYSA-N	280175	US10028961, Compound 328::US10172864, Compound 328::US10946023, Compound 328	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280175	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280175&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817331	378161724							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618013	Cc1nc(c[nH]1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H25F4N7/c1-11-24-10-14(25-11)15-28-16(26-12-2-6-18(20,21)7-3-12)30-17(29-15)27-13-4-8-19(22,23)9-5-13/h10,12-13H,2-9H2,1H3,(H,24,25)(H2,26,27,28,29,30)	OMGWTZOTCFNMGJ-UHFFFAOYSA-N	280179	US10028961, Compound 332::US10172864, Compound 332::US10946023, Compound 332	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280179	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280179&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817562	378161728							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618014	FC1(F)CCC(CC1)Nc1nc(NC2CCC(F)(F)CC2)nc(n1)-c1nc(ns1)-c1ccccc1	InChI=1S/C23H25F4N7S/c24-22(25)10-6-15(7-11-22)28-20-31-18(19-30-17(34-35-19)14-4-2-1-3-5-14)32-21(33-20)29-16-8-12-23(26,27)13-9-16/h1-5,15-16H,6-13H2,(H2,28,29,31,32,33)	VEBDQVKKCIRACB-UHFFFAOYSA-N	280180	US10028961, Compound 333::US10172864, Compound 333::US10946023, Compound 333	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280180	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280180&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817500	378161729							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618015	C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C15H13F9N6/c1-6(13(16,17)18)25-11-28-10(8-4-3-5-9(27-8)15(22,23)24)29-12(30-11)26-7(2)14(19,20)21/h3-7H,1-2H3,(H2,25,26,28,29,30)	QTNDXEZBEFRYER-UHFFFAOYSA-N	280263	US10028961, Compound 335::US10172864, Compound 335::US10946023, Compound 335	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280263	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280263&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817551	378161812							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618016	C[C@@H](Nc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-c1cncc(n1)C(F)F)C(F)(F)F |r|	InChI=1S/C20H16F5N9/c1-10(20(23,24)25)29-17-32-16(13-9-27-8-12(31-13)15(21)22)33-18(34-17)30-11-3-6-28-14(7-11)19(26-2)4-5-19/h3,6-10,15H,4-5H2,1H3,(H2,28,29,30,32,33,34)	LYMNHTLRCBLCIJ-UHFFFAOYSA-N	316463	US10172864, Compound 336	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316463	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316463&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123909934	383542688							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618017	C[C@H](Nc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-c1cncc(n1)C(F)F)C(F)(F)F |r|	InChI=1S/C20H16F5N9/c1-10(20(23,24)25)29-17-32-16(13-9-27-8-12(31-13)15(21)22)33-18(34-17)30-11-3-6-28-14(7-11)19(26-2)4-5-19/h3,6-10,15H,4-5H2,1H3,(H2,28,29,30,32,33,34)	LYMNHTLRCBLCIJ-UHFFFAOYSA-N	316464	US10172864, Compound 337	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316464	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316464&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123285969	383542689							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618018	FC(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C23H21F4N9/c1-28-22(7-8-22)17-10-14(4-9-30-17)32-21-35-19(16-12-29-11-15(33-16)18(24)25)34-20(36-21)31-13-2-5-23(26,27)6-3-13/h4,9-13,18H,2-3,5-8H2,(H2,30,31,32,34,35,36)	CEPPFWGKXWDKQR-UHFFFAOYSA-N	316465	US10172864, Compound 338	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316465	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316465&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123504376	383542690							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618019	CC[C@H](Nc1nc(N[C@@H](CC)C(F)(F)F)nc(n1)-c1cncc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C16H16F9N7/c1-3-8(14(17,18)19)28-12-30-11(7-5-26-6-10(27-7)16(23,24)25)31-13(32-12)29-9(4-2)15(20,21)22/h5-6,8-9H,3-4H2,1-2H3,(H2,28,29,30,31,32)	PVRJPVONIMLLSK-UHFFFAOYSA-N	280181	US10028961, Compound 339::US10172864, Compound 339::US10946023, Compound 339	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280181	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280181&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817364	378161730							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618020	FC(F)(F)c1cc(Nc2nc(N[C@@H]3CCC(F)(F)C3)nc(n2)-c2ccnc(n2)C(F)(F)F)ccn1 |r|	InChI=1S/C19H14F8N8/c20-17(21)4-1-10(8-17)31-16-34-13(11-3-6-29-14(32-11)19(25,26)27)33-15(35-16)30-9-2-5-28-12(7-9)18(22,23)24/h2-3,5-7,10H,1,4,8H2,(H2,28,30,31,33,34,35)	AZYHZXGJDLEMHT-UHFFFAOYSA-N	280182	US10028961, Compound 340::US10172864, Compound 340::US10946023, Compound 340	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280182	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280182&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799016	378161731							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618021	FC(F)(F)c1nccc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1 |r|	InChI=1S/C22H18F5N9/c1-28-20(6-7-20)15-10-12(3-8-29-15)31-18-34-16(14-4-9-30-17(33-14)22(25,26)27)35-19(36-18)32-13-2-5-21(23,24)11-13/h3-4,8-10,13H,2,5-7,11H2,(H2,29,31,32,34,35,36)	BMSFMFUPGRCJSV-UHFFFAOYSA-N	280183	US10028961, Compound 341::US10172864, Compound 341	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280183	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280183&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123266135	378161732							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618022	FC(F)(F)c1nccc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1 |r|	InChI=1S/C22H18F5N9/c1-28-20(6-7-20)15-10-12(3-8-29-15)31-18-34-16(14-4-9-30-17(33-14)22(25,26)27)35-19(36-18)32-13-2-5-21(23,24)11-13/h3-4,8-10,13H,2,5-7,11H2,(H2,29,31,32,34,35,36)	BMSFMFUPGRCJSV-UHFFFAOYSA-N	280184	US10028961, Compound 342::US10172864, Compound 342	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280184	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280184&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123855153	378161733							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618023	FC(F)(F)c1cc(Nc2nc(N[C@H]3CCC(F)(F)C3)nc(n2)-c2ccnc(n2)C(F)(F)F)ccn1 |r|	InChI=1S/C19H14F8N8/c20-17(21)4-1-10(8-17)31-16-34-13(11-3-6-29-14(32-11)19(25,26)27)33-15(35-16)30-9-2-5-28-12(7-9)18(22,23)24/h2-3,5-7,10H,1,4,8H2,(H2,28,30,31,33,34,35)	AZYHZXGJDLEMHT-UHFFFAOYSA-N	280185	US10028961, Compound 343::US10172864, Compound 343::US10946023, Compound 343	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280185	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280185&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799117	378161734							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618024	C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1ccnc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C14H12F9N7/c1-5(12(15,16)17)25-10-28-8(7-3-4-24-9(27-7)14(21,22)23)29-11(30-10)26-6(2)13(18,19)20/h3-6H,1-2H3,(H2,25,26,28,29,30)	OKFOLQBIBWUZIG-UHFFFAOYSA-N	280186	US10028961, Compound 344::US10172864, Compound 344::US10946023, Compound 344	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280186	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280186&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817545	378161735							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618025	CC[C@H](Nc1nc(N[C@@H](CC)C(F)(F)F)nc(n1)-c1ccnc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C16H16F9N7/c1-3-8(14(17,18)19)28-12-30-10(7-5-6-26-11(27-7)16(23,24)25)31-13(32-12)29-9(4-2)15(20,21)22/h5-6,8-9H,3-4H2,1-2H3,(H2,28,29,30,31,32)	BAHJVQDALFYMEG-UHFFFAOYSA-N	280187	US10028961, Compound 345::US10172864, Compound 345::US10946023, Compound 345	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280187	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280187&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817569	378161736							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618026	CC[C@H](Nc1nc(N[C@@H](CC)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C17H17F9N6/c1-3-9(15(18,19)20)28-13-30-12(8-6-5-7-11(27-8)17(24,25)26)31-14(32-13)29-10(4-2)16(21,22)23/h5-7,9-10H,3-4H2,1-2H3,(H2,28,29,30,31,32)	QTQWJQDDICMREO-UHFFFAOYSA-N	280188	US10028961, Compound 346::US10172864, Compound 346::US10946023, Compound 346	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280188	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280188&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817580	378161737							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618027	C[C@H](Nc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-c1cccc(n1)C(C)(F)F)C(F)(F)F |r|	InChI=1S/C22H19F5N8/c1-12(22(25,26)27)30-18-33-17(14-5-4-6-15(32-14)20(2,23)24)34-19(35-18)31-13-7-10-29-16(11-13)21(28-3)8-9-21/h4-7,10-12H,8-9H2,1-2H3,(H2,29,30,31,33,34,35)	OILUCLYZZMZARI-UHFFFAOYSA-N	316390	US10172864, Compound 347	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316390	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316390&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123184615	383542677							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618028	C[C@@H](Nc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-c1cccc(n1)C(C)(F)F)C(F)(F)F |r|	InChI=1S/C22H19F5N8/c1-12(22(25,26)27)30-18-33-17(14-5-4-6-15(32-14)20(2,23)24)34-19(35-18)31-13-7-10-29-16(11-13)21(28-3)8-9-21/h4-7,10-12H,8-9H2,1-2H3,(H2,29,30,31,33,34,35)	OILUCLYZZMZARI-UHFFFAOYSA-N	316391	US10172864, Compound 348	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316391&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123234812	383542678							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618029	C[C@H](Nc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C19H15F6N9/c1-10(18(20,21)22)28-14-30-15(29-11-3-7-27-13(9-11)17(26-2)5-6-17)32-16(31-14)34-8-4-12(33-34)19(23,24)25/h3-4,7-10H,5-6H2,1H3,(H2,27,28,29,30,31,32)	OQCGRHOQNOOHFP-UHFFFAOYSA-N	316392	US10172864, Compound 349	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316392	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316392&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123646516	383542679							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618030	FC(F)(F)c1ccn(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1 |r|	InChI=1S/C21H18F5N9/c1-27-19(6-7-19)15-10-12(3-8-28-15)29-16-31-17(30-13-2-5-20(22,23)11-13)33-18(32-16)35-9-4-14(34-35)21(24,25)26/h3-4,8-10,13H,2,5-7,11H2,(H2,28,29,30,31,32,33)	ZSYUHTUAGISLHX-UHFFFAOYSA-N	316393	US10172864, Compound 350	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316393&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123907163	383542680							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618031	FC(F)(F)c1ccn(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1 |r|	InChI=1S/C21H18F5N9/c1-27-19(6-7-19)15-10-12(3-8-28-15)29-16-31-17(30-13-2-5-20(22,23)11-13)33-18(32-16)35-9-4-14(34-35)21(24,25)26/h3-4,8-10,13H,2,5-7,11H2,(H2,28,29,30,31,32,33)	ZSYUHTUAGISLHX-UHFFFAOYSA-N	316393	US10172864, Compound 350	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316393&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123907163	383542680							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618033	C[C@H](Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C21H16F6N8/c1-11(20(22,23)24)30-17-33-16(13-3-2-4-14(32-13)21(25,26)27)34-18(35-17)31-12-5-8-29-15(9-12)19(10-28)6-7-19/h2-5,8-9,11H,6-7H2,1H3,(H2,29,30,31,33,34,35)	HJCRKYCQHOQKKS-UHFFFAOYSA-N	280193	US10028961, Compound 351::US10172864, Compound 351::US10946023, Compound 351	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280193	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280193&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817486	378161742							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618034	C[C@@H](Nc1nc(Nc2ccnc(c2)C2(CC2)C#N)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C21H16F6N8/c1-11(20(22,23)24)30-17-33-16(13-3-2-4-14(32-13)21(25,26)27)34-18(35-17)31-12-5-8-29-15(9-12)19(10-28)6-7-19/h2-5,8-9,11H,6-7H2,1H3,(H2,29,30,31,33,34,35)	HJCRKYCQHOQKKS-UHFFFAOYSA-N	280194	US10028961, Compound 352::US10172864, Compound 352::US10946023, Compound 352	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280194	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280194&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817489	378161743							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618035	FC(F)(F)c1csc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C18H13F8N7S/c19-16(20)3-1-9(6-16)29-15-32-12(13-30-11(7-34-13)18(24,25)26)31-14(33-15)28-8-2-4-27-10(5-8)17(21,22)23/h2,4-5,7,9H,1,3,6H2,(H2,27,28,29,31,32,33)	AQQOIBQYLSHDSV-UHFFFAOYSA-N	280195	US10028961, Compound 353::US10172864, Compound 353::US10946023, Compound 353	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280195	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280195&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817453	378161744							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618036	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC2(F)F)nc(NCC2CC2(F)F)n1	InChI=1S/C17H15F7N6/c18-15(19)4-8(15)6-25-13-28-12(10-2-1-3-11(27-10)17(22,23)24)29-14(30-13)26-7-9-5-16(9,20)21/h1-3,8-9H,4-7H2,(H2,25,26,28,29,30)	XHKYLNZMSNXADF-UHFFFAOYSA-N	280196	US10028961, Compound 354::US10172864, Compound 354::US10946023, Compound 354	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280196	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280196&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817488	378161745							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618037	CC(F)(F)c1cc(Nc2nc(N[C@@H]3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)ccn1 |r|	InChI=1S/C21H18F7N7/c1-19(22,23)15-9-11(6-8-29-15)30-17-33-16(13-3-2-4-14(32-13)21(26,27)28)34-18(35-17)31-12-5-7-20(24,25)10-12/h2-4,6,8-9,12H,5,7,10H2,1H3,(H2,29,30,31,33,34,35)	RJZGABPOSOZJRY-UHFFFAOYSA-N	280197	US10028961, Compound 355::US10172864, Compound 355::US10946023, Compound 355	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280197	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280197&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799376	378161746							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618038	C[C@H](Nc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C16H11F9N8/c1-7(14(17,18)19)27-11-29-12(28-8-2-4-26-10(6-8)16(23,24)25)31-13(30-11)33-5-3-9(32-33)15(20,21)22/h2-7H,1H3,(H2,26,27,28,29,30,31)	ORPDRKJAHZEOLR-UHFFFAOYSA-N	280198	US10028961, Compound 356::US10172864, Compound 356::US10946023, Compound 356	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280198	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280198&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817491	378161747							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618039	FC(F)(F)c1csc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C19H21F7N6S/c20-17(21)5-1-10(2-6-17)27-15-30-13(14-29-12(9-33-14)19(24,25)26)31-16(32-15)28-11-3-7-18(22,23)8-4-11/h9-11H,1-8H2,(H2,27,28,30,31,32)	AKRQSKYNRTUAQA-UHFFFAOYSA-N	280030	US10028961, Compound 183::US10172864, Compound 183::US10946023, Compound 183	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280030&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817122	378161580							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618040	CC(F)(F)c1cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)ccn1	InChI=1S/C20H16F7N7/c1-18(21,22)14-7-10(5-6-28-14)29-16-32-15(12-3-2-4-13(31-12)20(25,26)27)33-17(34-16)30-11-8-19(23,24)9-11/h2-7,11H,8-9H2,1H3,(H2,28,29,30,32,33,34)	NBLZOFNGJDPRRM-UHFFFAOYSA-N	280200	US10028961, Compound 358::US10172864, Compound 358::US10946023, Compound 358	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280200	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280200&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817563	378161749							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618041	C[C@@H](Nc1nc(Nc2ccnc(c2)-c2ccccc2)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C23H17F6N7/c1-13(22(24,25)26)31-20-34-19(16-8-5-9-18(33-16)23(27,28)29)35-21(36-20)32-15-10-11-30-17(12-15)14-6-3-2-4-7-14/h2-13H,1H3,(H2,30,31,32,34,35,36)	NWTISIXHXPIMSM-UHFFFAOYSA-N	280201	US10028961, Compound 359::US10172864, Compound 359::US10946023, Compound 359	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280201	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280201&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799238	378161750							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618042	CC(F)(F)c1cc(Nc2nc(N[C@H]3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)ccn1 |r|	InChI=1S/C21H18F7N7/c1-19(22,23)15-9-11(6-8-29-15)30-17-33-16(13-3-2-4-14(32-13)21(26,27)28)34-18(35-17)31-12-5-7-20(24,25)10-12/h2-4,6,8-9,12H,5,7,10H2,1H3,(H2,29,30,31,33,34,35)	RJZGABPOSOZJRY-UHFFFAOYSA-N	280202	US10028961, Compound 360::US10172864, Compound 360::US10946023, Compound 360	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280202	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280202&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799001	378161751							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618043	CC(F)(F)c1cc(Nc2nc(NC3CCC(F)(F)CC3)nc(n2)-c2cccc(n2)C(F)(F)F)ccn1	InChI=1S/C22H20F7N7/c1-20(23,24)16-11-13(7-10-30-16)32-19-35-17(14-3-2-4-15(33-14)22(27,28)29)34-18(36-19)31-12-5-8-21(25,26)9-6-12/h2-4,7,10-12H,5-6,8-9H2,1H3,(H2,30,31,32,34,35,36)	RSCDXFNMGRWMJK-UHFFFAOYSA-N	280203	US10028961, Compound 361::US10172864, Compound 361::US10946023, Compound 361	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280203	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280203&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799134	378161752							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618044	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC2(F)F)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C22H17F5N8/c1-28-20(6-7-20)16-9-13(5-8-29-16)31-19-34-17(14-3-2-4-15(32-14)22(25,26)27)33-18(35-19)30-11-12-10-21(12,23)24/h2-5,8-9,12H,6-7,10-11H2,(H2,29,30,31,33,34,35)	IDXVUZYNOWDXDF-UHFFFAOYSA-N	316405	US10172864, Compound 362	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316405	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316405&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123627133	383542681							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618045	CC[C@H](Nc1nc(N[C@@H](CC)C(F)(F)F)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C15H16F9N7/c1-3-7(13(16,17)18)25-10-27-11(26-8(4-2)14(19,20)21)29-12(28-10)31-6-5-9(30-31)15(22,23)24/h5-8H,3-4H2,1-2H3,(H2,25,26,27,28,29)	CNPVZLAVEHNGOP-UHFFFAOYSA-N	280205	US10028961, Compound 363::US10172864, Compound 363::US10946023, Compound 363	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280205	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280205&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817560	378161754							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618046	C[C@@H](Nc1nc(Nc2ccnc(c2)-c2ccc(Cl)cc2)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C23H16ClF6N7/c1-12(22(25,26)27)32-20-35-19(16-3-2-4-18(34-16)23(28,29)30)36-21(37-20)33-15-9-10-31-17(11-15)13-5-7-14(24)8-6-13/h2-12H,1H3,(H2,31,32,33,35,36,37)	IETQZYOXYCRTPQ-UHFFFAOYSA-N	280206	US10028961, Compound 364::US10172864, Compound 364::US10946023, Compound 364	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280206	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280206&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799131	378161755							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618047	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC2(F)F)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C19H13F8N7/c20-17(21)7-9(17)8-29-15-32-14(11-2-1-3-12(31-11)18(22,23)24)33-16(34-15)30-10-4-5-28-13(6-10)19(25,26)27/h1-6,9H,7-8H2,(H2,28,29,30,32,33,34)	JSIARFQDVBMCLB-UHFFFAOYSA-N	280207	US10028961, Compound 365::US10172864, Compound 365::US10946023, Compound 365	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280207	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280207&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798965	378161756							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618048	CC(F)(F)c1cncc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C17H17F6N7/c1-15(18,19)11-7-24-6-10(27-11)12-28-13(25-8-2-16(20,21)3-8)30-14(29-12)26-9-4-17(22,23)5-9/h6-9H,2-5H2,1H3,(H2,25,26,28,29,30)	CDUYLYBNWORMLM-UHFFFAOYSA-N	280208	US10028961, Compound 366::US10172864, Compound 366::US10946023, Compound 366	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280208	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280208&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817559	378161757							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618049	Fc1cc(F)cc(Nc2nc(NC3CCC(F)(F)CC3)nc(n2)-c2cncc(n2)C(F)(F)F)c1	InChI=1S/C20H16F7N7/c21-10-5-11(22)7-13(6-10)30-18-33-16(14-8-28-9-15(31-14)20(25,26)27)32-17(34-18)29-12-1-3-19(23,24)4-2-12/h5-9,12H,1-4H2,(H2,29,30,32,33,34)	CUSSJQLSJJSNTA-UHFFFAOYSA-N	280209	US10028961, Compound 367::US10172864, Compound 367::US10946023, Compound 367	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280209	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280209&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817564	378161758							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618050	Fc1cc(F)cc(Nc2nc(N[C@H]3CCC(F)(F)C3)nc(n2)-c2cncc(n2)C(F)(F)F)c1 |r|	InChI=1S/C19H14F7N7/c20-9-3-10(21)5-12(4-9)29-17-32-15(13-7-27-8-14(30-13)19(24,25)26)31-16(33-17)28-11-1-2-18(22,23)6-11/h3-5,7-8,11H,1-2,6H2,(H2,28,29,31,32,33)	ZPNAECASCHOTOG-UHFFFAOYSA-N	280210	US10028961, Compound 368::US10172864, Compound 368::US10946023, Compound 368	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280210	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280210&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817404	378161759							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618051	Fc1cc(F)cc(Nc2nc(N[C@H]3CCC(F)(F)C3)nc(n2)-c2cncc(n2)C(F)(F)F)c1 |r|	InChI=1S/C19H14F7N7/c20-9-3-10(21)5-12(4-9)29-17-32-15(13-7-27-8-14(30-13)19(24,25)26)31-16(33-17)28-11-1-2-18(22,23)6-11/h3-5,7-8,11H,1-2,6H2,(H2,28,29,31,32,33)	ZPNAECASCHOTOG-UHFFFAOYSA-N	280210	US10028961, Compound 368::US10172864, Compound 368::US10946023, Compound 368	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280210	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280210&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817404	378161759							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618052	Fc1cc(F)cc(Nc2nc(N[C@@H]3CCC(F)(F)C3)nc(n2)-c2cncc(n2)C(F)(F)F)c1 |r|	InChI=1S/C19H14F7N7/c20-9-3-10(21)5-12(4-9)29-17-32-15(13-7-27-8-14(30-13)19(24,25)26)31-16(33-17)28-11-1-2-18(22,23)6-11/h3-5,7-8,11H,1-2,6H2,(H2,28,29,31,32,33)	ZPNAECASCHOTOG-UHFFFAOYSA-N	280211	US10028961, Compound 369::US10172864, Compound 369::US10946023, Compound 369	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280211	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280211&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817407	378161760							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618053	CC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C19H21F6N7/c1-17(20,21)13-9-26-8-12(29-13)14-30-15(27-10-2-4-18(22,23)6-10)32-16(31-14)28-11-3-5-19(24,25)7-11/h8-11H,2-7H2,1H3,(H2,27,28,30,31,32)	HZKDADBLQPSIOY-UHFFFAOYSA-N	280212	US10028961, Compound 370::US10172864, Compound 370::US10946023, Compound 370	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280212	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280212&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817403	378161761							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618054	C[C@@H](Nc1nc(Nc2ccnc(c2)-c2ccc(F)cc2)nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C23H16F7N7/c1-12(22(25,26)27)32-20-35-19(16-3-2-4-18(34-16)23(28,29)30)36-21(37-20)33-15-9-10-31-17(11-15)13-5-7-14(24)8-6-13/h2-12H,1H3,(H2,31,32,33,35,36,37)	AIVPAWKVFHFNSZ-UHFFFAOYSA-N	280213	US10028961, Compound 371::US10172864, Compound 371::US10946023, Compound 371	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280213	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280213&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799215	378161762							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618055	CC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C23H20F4N8/c1-21(24,25)16-4-2-3-15(32-16)18-33-19(35-20(34-18)31-14-10-23(26,27)11-14)30-13-5-8-29-17(9-13)22(12-28)6-7-22/h2-5,8-9,14H,6-7,10-11H2,1H3,(H2,29,30,31,33,34,35)	RTZBPKFZOQGNAS-UHFFFAOYSA-N	280214	US10028961, Compound 372::US10172864, Compound 372::US10946023, Compound 372	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280214	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280214&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799242	378161763							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618056	FC(F)(F)c1cncc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1 |r|	InChI=1S/C22H18F5N9/c1-28-20(5-6-20)15-8-12(3-7-30-15)31-18-34-17(14-10-29-11-16(33-14)22(25,26)27)35-19(36-18)32-13-2-4-21(23,24)9-13/h3,7-8,10-11,13H,2,4-6,9H2,(H2,30,31,32,34,35,36)	HMXVERBLXZDCDV-UHFFFAOYSA-N	280215	US10028961, Compound 373::US10172864, Compound 373	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280215	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280215&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123990677	378161764							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618057	CC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H25F6N7/c1-19(22,23)15-11-28-10-14(31-15)16-32-17(29-12-2-6-20(24,25)7-3-12)34-18(33-16)30-13-4-8-21(26,27)9-5-13/h10-13H,2-9H2,1H3,(H2,29,30,32,33,34)	IXEKFWPZLJDVJT-UHFFFAOYSA-N	280216	US10028961, Compound 374::US10172864, Compound 374::US10946023, Compound 374	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280216	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280216&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817406	378161765							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618058	FC(F)(F)c1ccnc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1 |r|	InChI=1S/C22H18F5N9/c23-21(24)4-1-13(10-21)32-19-35-17(16-30-8-3-14(33-16)22(25,26)27)34-18(36-19)31-12-2-7-29-15(9-12)20(11-28)5-6-20/h2-3,7-9,13H,1,4-6,10H2,(H2,29,31,32,34,35,36)	NQLUCGNQWCNNAV-UHFFFAOYSA-N	280217	US10028961, Compound 375::US10172864, Compound 375::US10946023, Compound 375	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280217	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280217&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			122440956	378161766							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618059	FC(F)(F)c1ccnc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1 |r|	InChI=1S/C22H18F5N9/c23-21(24)4-1-13(10-21)32-19-35-17(16-30-8-3-14(33-16)22(25,26)27)34-18(36-19)31-12-2-7-29-15(9-12)20(11-28)5-6-20/h2-3,7-9,13H,1,4-6,10H2,(H2,29,31,32,34,35,36)	NQLUCGNQWCNNAV-UHFFFAOYSA-N	280218	US10028961, Compound 376::US10172864, Compound 376::US10946023, Compound 376	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280218	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280218&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799341	378161767							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618060	C[C@@H](Nc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-c1cncc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C20H15F6N9/c1-10(19(21,22)23)30-16-33-15(12-8-28-9-14(32-12)20(24,25)26)34-17(35-16)31-11-3-6-29-13(7-11)18(27-2)4-5-18/h3,6-10H,4-5H2,1H3,(H2,29,30,31,33,34,35)	GBDQSBBADNAMJV-UHFFFAOYSA-N	316420	US10172864, Compound 377	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316420	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316420&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123944925	383542682							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618061	FC(F)(F)c1cncc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1 |r|	InChI=1S/C22H18F5N9/c1-28-20(5-6-20)15-8-12(3-7-30-15)31-18-34-17(14-10-29-11-16(33-14)22(25,26)27)35-19(36-18)32-13-2-4-21(23,24)9-13/h3,7-8,10-11,13H,2,4-6,9H2,(H2,30,31,32,34,35,36)	HMXVERBLXZDCDV-UHFFFAOYSA-N	316421	US10172864, Compound 378	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316421	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316421&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123836992	383542683							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618062	FC(F)(F)c1csc(n1)-c1nc(NCC2CC2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C17H13F6N7S/c18-16(19,20)10-5-9(3-4-24-10)26-15-29-12(13-27-11(7-31-13)17(21,22)23)28-14(30-15)25-6-8-1-2-8/h3-5,7-8H,1-2,6H2,(H2,24,25,26,28,29,30)	KUPZRBAQHZPHES-UHFFFAOYSA-N	280221	US10028961, Compound 379::US10172864, Compound 379::US10946023, Compound 379	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280221	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280221&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817130	378161770							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618063	FC(F)(F)c1cncc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C21H16F8N8/c22-19(23)8-18(9-19)4-11(5-18)33-17-36-15(12-6-30-7-14(34-12)21(27,28)29)35-16(37-17)32-10-1-2-31-13(3-10)20(24,25)26/h1-3,6-7,11H,4-5,8-9H2,(H2,31,32,33,35,36,37)	UQNYKCNMQIBEFQ-UHFFFAOYSA-N	280222	US10028961, Compound 380::US10172864, Compound 380::US10946023, Compound 380	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280222	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280222&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799022	378161771							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618064	FC(F)(F)c1ccn(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C#N)n1 |r|	InChI=1S/C18H14F5N9/c19-17(20)4-1-11(8-17)27-15-28-14(26-10-2-5-25-12(7-10)9-24)29-16(30-15)32-6-3-13(31-32)18(21,22)23/h2-3,5-7,11H,1,4,8H2,(H2,25,26,27,28,29,30)	LUJOXCPZQNCMMB-UHFFFAOYSA-N	280223	US10028961, Compound 381::US10172864, Compound 381::US10946023, Compound 381	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280223	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280223&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817181	378161772							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618065	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C22H20F5N9/c1-28-20(8-9-20)16-12-14(4-10-29-16)31-18-32-17(30-13-2-6-21(23,24)7-3-13)33-19(34-18)36-11-5-15(35-36)22(25,26)27/h4-5,10-13H,2-3,6-9H2,(H2,29,30,31,32,33,34)	JTVHZHFBVAULDV-UHFFFAOYSA-N	280224	US10028961, Compound 382::US10172864, Compound 382	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280224	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280224&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123605512	378161773							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618066	FC(F)(F)c1ccn(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C22H20F5N9/c1-28-20(8-9-20)16-12-14(4-10-29-16)31-18-32-17(30-13-2-6-21(23,24)7-3-13)33-19(34-18)36-11-5-15(35-36)22(25,26)27/h4-5,10-13H,2-3,6-9H2,(H2,29,30,31,32,33,34)	JTVHZHFBVAULDV-UHFFFAOYSA-N	280224	US10028961, Compound 382::US10172864, Compound 382	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280224	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280224&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123605512	378161773							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618067	C[C@@H](Nc1nc(Nc2ccnc(c2)-c2ccc(cc2)[N+]#[C-])nc(n1)-c1cccc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C24H16F6N8/c1-13(23(25,26)27)33-21-36-20(17-4-3-5-19(35-17)24(28,29)30)37-22(38-21)34-16-10-11-32-18(12-16)14-6-8-15(31-2)9-7-14/h3-13H,1H3,(H2,32,33,34,36,37,38)	GEJISPDXPBOJLP-UHFFFAOYSA-N	280225	US10028961, Compound 383::US10172864, Compound 383	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280225	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280225&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123590184	378161774							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618068	CC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C24H22F4N8/c1-22(25,26)17-4-2-3-16(33-17)19-34-20(36-21(35-19)32-15-5-7-24(27,28)12-15)31-14-6-10-30-18(11-14)23(13-29)8-9-23/h2-4,6,10-11,15H,5,7-9,12H2,1H3,(H2,30,31,32,34,35,36)	QUGNBYVSVJORNT-UHFFFAOYSA-N	280226	US10028961, Compound 384::US10172864, Compound 384::US10946023, Compound 384	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280226	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280226&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817179	378161775							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618069	FC(F)(F)c1cncc(n1)-c1nc(NC2CC3(C2)CC(F)(F)C3)nc(Nc2ccnc(c2)C2(CC2)C#N)n1	InChI=1S/C24H20F5N9/c25-23(26)10-21(11-23)6-14(7-21)34-20-37-18(15-8-31-9-17(35-15)24(27,28)29)36-19(38-20)33-13-1-4-32-16(5-13)22(12-30)2-3-22/h1,4-5,8-9,14H,2-3,6-7,10-11H2,(H2,32,33,34,36,37,38)	RFILWRLBMXUUTD-UHFFFAOYSA-N	280227	US10028961, Compound 385::US10172864, Compound 385::US10946023, Compound 385	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280227	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280227&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817131	378161776							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618070	C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cncc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C14H12F9N7/c1-5(12(15,16)17)25-10-28-9(7-3-24-4-8(27-7)14(21,22)23)29-11(30-10)26-6(2)13(18,19)20/h3-6H,1-2H3,(H2,25,26,28,29,30)	WRRBNOCENGULOH-UHFFFAOYSA-N	280228	US10028961, Compound 386::US10172864, Compound 386::US10946023, Compound 386	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280228	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280228&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799027	378161777							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618071	FC(F)(F)c1cncc(n1)-c1nc(NCC2CC2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C18H14F6N8/c19-17(20,21)12-5-10(3-4-26-12)28-16-31-14(30-15(32-16)27-6-9-1-2-9)11-7-25-8-13(29-11)18(22,23)24/h3-5,7-9H,1-2,6H2,(H2,26,27,28,30,31,32)	FUVOVGXLXPPLTC-UHFFFAOYSA-N	280229	US10028961, Compound 387::US10172864, Compound 387::US10946023, Compound 387	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280229	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280229&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817183	378161778							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618072	FC(F)(F)c1csc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C17H11F8N7S/c18-15(19)4-8(5-15)28-14-31-11(12-29-10(6-33-12)17(23,24)25)30-13(32-14)27-7-1-2-26-9(3-7)16(20,21)22/h1-3,6,8H,4-5H2,(H2,26,27,28,30,31,32)	FIHMFIIGBKKTHS-UHFFFAOYSA-N	280230	US10028961, Compound 388::US10172864, Compound 388::US10946023, Compound 388	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280230	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280230&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817151	378161779							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618073	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H16F8N8/c21-18(22)4-1-10(2-5-18)31-16-34-15(12-8-29-9-14(33-12)20(26,27)28)35-17(36-16)32-11-3-6-30-13(7-11)19(23,24)25/h3,6-10H,1-2,4-5H2,(H2,30,31,32,34,35,36)	DZAOGXHFTBFLFH-UHFFFAOYSA-N	280231	US10028961, Compound 389::US10172864, Compound 389::US10946023, Compound 389	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280231	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280231&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817166	378161780							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618074	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C20H16F8N8/c21-18(22)4-1-10(2-5-18)31-16-34-15(12-8-29-9-14(33-12)20(26,27)28)35-17(36-16)32-11-3-6-30-13(7-11)19(23,24)25/h3,6-10H,1-2,4-5H2,(H2,30,31,32,34,35,36)	DZAOGXHFTBFLFH-UHFFFAOYSA-N	280231	US10028961, Compound 389::US10172864, Compound 389::US10946023, Compound 389	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280231	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280231&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817166	378161780							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618076	FC(F)(F)c1cncc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C18H12F8N8/c19-16(20)4-9(5-16)30-15-33-13(10-6-27-7-12(31-10)18(24,25)26)32-14(34-15)29-8-1-2-28-11(3-8)17(21,22)23/h1-3,6-7,9H,4-5H2,(H2,28,29,30,32,33,34)	QQGZDIVDOFXSIU-UHFFFAOYSA-N	280232	US10028961, Compound 390::US10172864, Compound 390::US10946023, Compound 390	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280232	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280232&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799171	378161781							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618077	FC(F)(F)c1cncc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C19H14F8N8/c20-17(21)3-1-10(6-17)31-16-34-14(11-7-28-8-13(32-11)19(25,26)27)33-15(35-16)30-9-2-4-29-12(5-9)18(22,23)24/h2,4-5,7-8,10H,1,3,6H2,(H2,29,30,31,33,34,35)	ONCVYPCVWHYEJW-UHFFFAOYSA-N	280233	US10028961, Compound 391::US10172864, Compound 391::US10946023, Compound 391	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280233	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280233&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799014	378161782							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618078	FC(F)(F)c1cncc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C19H14F8N8/c20-17(21)3-1-10(6-17)31-16-34-14(11-7-28-8-13(32-11)19(25,26)27)33-15(35-16)30-9-2-4-29-12(5-9)18(22,23)24/h2,4-5,7-8,10H,1,3,6H2,(H2,29,30,31,33,34,35)	ONCVYPCVWHYEJW-UHFFFAOYSA-N	280233	US10028961, Compound 391::US10172864, Compound 391::US10946023, Compound 391	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280233	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280233&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799014	378161782							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618080	C[C@@H](Nc1nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C19H15F6N9/c1-10(18(20,21)22)28-14-30-15(29-11-3-7-27-13(9-11)17(26-2)5-6-17)32-16(31-14)34-8-4-12(33-34)19(23,24)25/h3-4,7-10H,5-6H2,1H3,(H2,27,28,29,30,31,32)	OQCGRHOQNOOHFP-UHFFFAOYSA-N	280234	US10028961, Compound 392::US10172864, Compound 392	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280234	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280234&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123157861	378161783							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618081	FC(F)(F)c1ccn(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C18H14F8N8/c19-16(20)4-1-10(8-16)29-14-30-13(28-9-2-5-27-12(7-9)18(24,25)26)31-15(32-14)34-6-3-11(33-34)17(21,22)23/h2-3,5-7,10H,1,4,8H2,(H2,27,28,29,30,31,32)	RACFSMUYWZWUMF-UHFFFAOYSA-N	280235	US10028961, Compound 393::US10172864, Compound 393::US10946023, Compound 393	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280235	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280235&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799021	378161784							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618082	FC(F)(F)c1ccn(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C(F)(F)F)n1 |r|	InChI=1S/C18H14F8N8/c19-16(20)4-1-10(8-16)29-14-30-13(28-9-2-5-27-12(7-9)18(24,25)26)31-15(32-14)34-6-3-11(33-34)17(21,22)23/h2-3,5-7,10H,1,4,8H2,(H2,27,28,29,30,31,32)	RACFSMUYWZWUMF-UHFFFAOYSA-N	280235	US10028961, Compound 393::US10172864, Compound 393::US10946023, Compound 393	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280235	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280235&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799021	378161784							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618084	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C23H20F5N9/c1-29-21(7-8-21)16-10-14(4-9-31-16)33-20-36-18(15-11-30-12-17(34-15)23(26,27)28)35-19(37-20)32-13-2-5-22(24,25)6-3-13/h4,9-13H,2-3,5-8H2,(H2,31,32,33,35,36,37)	NZWQLAGSWXCELF-UHFFFAOYSA-N	280236	US10028961, Compound 394::US10172864, Compound 394	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280236	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280236&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123606255	378161785							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618085	FC(F)(F)c1cccc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)CC2)n1	InChI=1S/C20H21F7N6/c21-18(22)7-4-11(5-8-18)28-16-31-15(13-2-1-3-14(30-13)20(25,26)27)32-17(33-16)29-12-6-9-19(23,24)10-12/h1-3,11-12H,4-10H2,(H2,28,29,31,32,33)	TZKFRDJJAGMBLQ-UHFFFAOYSA-N	280237	US10028961, Compound 395::US10172864, Compound 395::US10946023, Compound 395	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280237	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280237&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817190	378161786							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618087	CC(C)(O)CNc1nc(Nc2cc(F)cc(c2)C(F)F)nc(n1)-c1cccc(n1)C(C)(F)F	InChI=1S/C21H21F5N6O/c1-20(2,33)10-27-18-30-17(14-5-4-6-15(29-14)21(3,25)26)31-19(32-18)28-13-8-11(16(23)24)7-12(22)9-13/h4-9,16,33H,10H2,1-3H3,(H2,27,28,30,31,32)	LHOQDBZIMPLZAP-UHFFFAOYSA-N	316439	US10172864, Compound 397	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316439	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316439&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138106841	383542684							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618088	CC(C)(O)CNc1nc(Nc2cc(F)cc(c2)[N+]#[C-])nc(n1)-c1cccc(n1)C(C)(F)F	InChI=1S/C21H20F3N7O/c1-20(2,32)11-26-18-29-17(15-6-5-7-16(28-15)21(3,23)24)30-19(31-18)27-14-9-12(22)8-13(10-14)25-4/h5-10,32H,11H2,1-3H3,(H2,26,27,29,30,31)	DFRJBWOYWCETOL-UHFFFAOYSA-N	316440	US10172864, Compound 398	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316440	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316440&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123164893	383542685							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618089	FC(F)(F)c1cncc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(N[C@@H]2CCC(F)(F)C2)n1 |r|	InChI=1S/C18H18F7N7/c19-16(20)3-1-9(5-16)27-14-30-13(11-7-26-8-12(29-11)18(23,24)25)31-15(32-14)28-10-2-4-17(21,22)6-10/h7-10H,1-6H2,(H2,27,28,30,31,32)	YWUBJNPVIIBDPD-UHFFFAOYSA-N	280240	US10028961, Compound 399::US10172864, Compound 399::US10946023, Compound 399	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280240	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280240&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817142	378161789							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618090	C[C@@H](Nc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C16H11F9N8/c1-7(14(17,18)19)27-11-29-12(28-8-2-4-26-10(6-8)16(23,24)25)31-13(30-11)33-5-3-9(32-33)15(20,21)22/h2-7H,1H3,(H2,26,27,28,29,30,31)	ORPDRKJAHZEOLR-UHFFFAOYSA-N	280241	US10028961, Compound 400::US10172864, Compound 400::US10946023, Compound 400	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280241	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280241&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817128	378161790							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618091	C[C@@H](Nc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-n1ccc(n1)C(F)(F)F)C(F)(F)F |r|	InChI=1S/C16H11F9N8/c1-7(14(17,18)19)27-11-29-12(28-8-2-4-26-10(6-8)16(23,24)25)31-13(30-11)33-5-3-9(32-33)15(20,21)22/h2-7H,1H3,(H2,26,27,28,29,30,31)	ORPDRKJAHZEOLR-UHFFFAOYSA-N	280241	US10028961, Compound 400::US10172864, Compound 400::US10946023, Compound 400	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280241	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280241&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817128	378161790							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618093	FC(F)(F)c1cncc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C21H16F5N9/c1-27-19(3-4-19)14-6-11(2-5-29-14)30-17-33-16(13-9-28-10-15(32-13)21(24,25)26)34-18(35-17)31-12-7-20(22,23)8-12/h2,5-6,9-10,12H,3-4,7-8H2,(H2,29,30,31,33,34,35)	JQPXXLMNBIGQIB-UHFFFAOYSA-N	316443	US10172864, Compound 401	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316443&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123753384	383542686							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618094	FC(F)(F)c1cncc(n1)-c1nc(NC2CC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)[N+]#[C-])n1	InChI=1S/C21H16F5N9/c1-27-19(3-4-19)14-6-11(2-5-29-14)30-17-33-16(13-9-28-10-15(32-13)21(24,25)26)34-18(35-17)31-12-7-20(22,23)8-12/h2,5-6,9-10,12H,3-4,7-8H2,(H2,29,30,31,33,34,35)	JQPXXLMNBIGQIB-UHFFFAOYSA-N	316443	US10172864, Compound 401	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=316443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=316443&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123753384	383542686							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618096	FC(F)c1csc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C17H18F6N6S/c18-11(19)10-7-30-13(26-10)12-27-14(24-8-1-3-16(20,21)5-8)29-15(28-12)25-9-2-4-17(22,23)6-9/h7-9,11H,1-6H2,(H2,24,25,27,28,29)	VSPSEEIARINUPO-UHFFFAOYSA-N	280243	US10028961, Compound 402::US10172864, Compound 402::US10946023, Compound 402	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280243	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280243&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817157	378161792							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618097	FC(F)c1csc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C15H14F6N6S/c16-9(17)8-5-28-11(24-8)10-25-12(22-6-1-14(18,19)2-6)27-13(26-10)23-7-3-15(20,21)4-7/h5-7,9H,1-4H2,(H2,22,23,25,26,27)	GVVHKJZVVILBHY-UHFFFAOYSA-N	280244	US10028961, Compound 403::US10172864, Compound 403::US10946023, Compound 403	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280244	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280244&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817129	378161793							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618098	CC(Nc1nc(NC(C)C(F)(F)F)nc(n1)-c1nc(cs1)C(F)(F)F)C(F)(F)F	InChI=1S/C13H11F9N6S/c1-4(11(14,15)16)23-9-26-7(8-25-6(3-29-8)13(20,21)22)27-10(28-9)24-5(2)12(17,18)19/h3-5H,1-2H3,(H2,23,24,26,27,28)	HMRKPTGJADCEIY-UHFFFAOYSA-N	280245	US10028961, Compound 404::US10172864, Compound 404::US10946023, Compound 404	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280245	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280245&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817154	378161794							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618099	FC(F)(F)c1cncc(Nc2nc(NC3CCC(F)(F)C3)nc(n2)-c2cccc(n2)C(F)(F)F)c1	InChI=1S/C20H15F8N7/c21-18(22)5-4-11(7-18)30-16-33-15(13-2-1-3-14(32-13)20(26,27)28)34-17(35-16)31-12-6-10(8-29-9-12)19(23,24)25/h1-3,6,8-9,11H,4-5,7H2,(H2,30,31,33,34,35)	LRFCOIWENOAQEZ-UHFFFAOYSA-N	280246	US10028961, Compound 405::US10172864, Compound 405::US10946023, Compound 405	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280246	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280246&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117799030	378161795							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618100	FC(F)(F)c1cncc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(N[C@H]2CCC(F)(F)C2)n1 |r|	InChI=1S/C18H18F7N7/c19-16(20)3-1-9(5-16)27-14-30-13(11-7-26-8-12(29-11)18(23,24)25)31-15(32-14)28-10-2-4-17(21,22)6-10/h7-10H,1-6H2,(H2,27,28,30,31,32)	YWUBJNPVIIBDPD-UHFFFAOYSA-N	280247	US10028961, Compound 406::US10172864, Compound 406::US10946023, Compound 406	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280247	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280247&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817144	378161796							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618101	FC(F)(F)c1ccn(n1)-c1nc(NCC2CC2)nc(Nc2ccnc(c2)C(F)(F)F)n1	InChI=1S/C17H14F6N8/c18-16(19,20)11-4-6-31(30-11)15-28-13(25-8-9-1-2-9)27-14(29-15)26-10-3-5-24-12(7-10)17(21,22)23/h3-7,9H,1-2,8H2,(H2,24,25,26,27,28,29)	LMVUIUXDPQOTEI-UHFFFAOYSA-N	280248	US10028961, Compound 407::US10172864, Compound 407::US10946023, Compound 407	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280248	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280248&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117798945	378161797							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618102	FC(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H19F6N7/c19-13(20)11-7-25-8-12(28-11)14-29-15(26-9-1-3-17(21,22)5-9)31-16(30-14)27-10-2-4-18(23,24)6-10/h7-10,13H,1-6H2,(H2,26,27,29,30,31)	IYNSADUHPNFIGN-UHFFFAOYSA-N	280249	US10028961, Compound 408::US10172864, Compound 408::US10946023, Compound 408	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280249	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280249&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817146	378161798							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618103	FC(F)c1cncc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H15F6N7/c17-11(18)9-5-23-6-10(26-9)12-27-13(24-7-1-15(19,20)2-7)29-14(28-12)25-8-3-16(21,22)4-8/h5-8,11H,1-4H2,(H2,24,25,27,28,29)	YIFYCTDCEXPZOP-UHFFFAOYSA-N	280250	US10028961, Compound 409::US10172864, Compound 409::US10946023, Compound 409	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280250	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280250&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817185	378161799							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618104	FC(F)(F)c1cncc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(N[C@@H]2CCC(F)(F)C2)n1 |r|	InChI=1S/C18H18F7N7/c19-16(20)3-1-9(5-16)27-14-30-13(11-7-26-8-12(29-11)18(23,24)25)31-15(32-14)28-10-2-4-17(21,22)6-10/h7-10H,1-6H2,(H2,27,28,30,31,32)	YWUBJNPVIIBDPD-UHFFFAOYSA-N	280251	US10028961, Compound 410::US10172864, Compound 410::US10946023, Compound 410	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280251	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280251&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817192	378161800							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618105	FC(F)(F)c1cncc(n1)-c1nc(N[C@@H]2CCC(F)(F)C2)nc(N[C@@H]2CCC(F)(F)C2)n1 |r|	InChI=1S/C18H18F7N7/c19-16(20)3-1-9(5-16)27-14-30-13(11-7-26-8-12(29-11)18(23,24)25)31-15(32-14)28-10-2-4-17(21,22)6-10/h7-10H,1-6H2,(H2,27,28,30,31,32)	YWUBJNPVIIBDPD-UHFFFAOYSA-N	280251	US10028961, Compound 410::US10172864, Compound 410::US10946023, Compound 410	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280251	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280251&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817192	378161800							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618107	FC(F)c1ccnc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1	InChI=1S/C16H15F6N7/c17-10(18)9-1-2-23-11(26-9)12-27-13(24-7-3-15(19,20)4-7)29-14(28-12)25-8-5-16(21,22)6-8/h1-2,7-8,10H,3-6H2,(H2,24,25,27,28,29)	YNUDPCHEAJUNPU-UHFFFAOYSA-N	280252	US10028961, Compound 411::US10172864, Compound 411::US10946023, Compound 411	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280252	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280252&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817193	378161801							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618108	FC(F)c1ccnc(n1)-c1nc(NC2CCC(F)(F)C2)nc(NC2CCC(F)(F)C2)n1	InChI=1S/C18H19F6N7/c19-12(20)11-3-6-25-13(28-11)14-29-15(26-9-1-4-17(21,22)7-9)31-16(30-14)27-10-2-5-18(23,24)8-10/h3,6,9-10,12H,1-2,4-5,7-8H2,(H2,26,27,29,30,31)	QHLSBPRKCLATLW-UHFFFAOYSA-N	280253	US10028961, Compound 412::US10172864, Compound 412::US10946023, Compound 412	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280253	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280253&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817187	378161802							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618109	Fc1cc(F)cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2nc(cs2)C(F)(F)F)c1	InChI=1S/C17H11F7N6S/c18-7-1-8(19)3-9(2-7)25-14-28-12(13-27-11(6-31-13)17(22,23)24)29-15(30-14)26-10-4-16(20,21)5-10/h1-3,6,10H,4-5H2,(H2,25,26,28,29,30)	WGWIGBTYVJCEKX-UHFFFAOYSA-N	280254	US10028961, Compound 413::US10172864, Compound 413::US10946023, Compound 413	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796520	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280254	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280254&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817195	378161803							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618110	Fc1cc(F)cc(Nc2nc(NC3CC(F)(F)C3)nc(n2)-c2nc(cs2)C(F)(F)F)c1	InChI=1S/C17H11F7N6S/c18-7-1-8(19)3-9(2-7)25-14-28-12(13-27-11(6-31-13)17(22,23)24)29-15(30-14)26-10-4-16(20,21)5-10/h1-3,6,10H,4-5H2,(H2,25,26,28,29,30)	WGWIGBTYVJCEKX-UHFFFAOYSA-N	280254	US10028961, Compound 413::US10172864, Compound 413::US10946023, Compound 413	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<50							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280254	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280254&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817195	378161803							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618111	C[C@@H](Nc1cc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C20H24F3N5/c1-11(13-6-7-13)24-17-10-18(25-12(2)14-8-9-14)28-19(27-17)15-4-3-5-16(26-15)20(21,22)23/h3-5,10-14H,6-9H2,1-2H3,(H2,24,25,27,28)	MEKMADZCSPFPMP-UHFFFAOYSA-N	280255	US10028961, Compound 414::US10172864, Compound 414::US10946023, Compound 414	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 75							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280255	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280255&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817191	378161804							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618115	C[C@@H](Nc1cc(NC(C)(C)C)nc(n1)-c1cccc(n1)C(F)(F)F)C1CC1 |r|	InChI=1S/C19H24F3N5/c1-11(12-8-9-12)23-15-10-16(27-18(2,3)4)26-17(25-15)13-6-5-7-14(24-13)19(20,21)22/h5-7,10-12H,8-9H2,1-4H3,(H2,23,25,26,27)	SICOBUZBFFTRIB-UHFFFAOYSA-N	280258	US10028961, Compound 417::US10172864, Compound 417::US10946023, Compound 417	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280258	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280258&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817175	378161807							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618117	FC(F)(F)c1cccc(n1)-c1nc(NCC2CC2)cc(NCC2CC2)n1	InChI=1S/C18H20F3N5/c19-18(20,21)14-3-1-2-13(24-14)17-25-15(22-9-11-4-5-11)8-16(26-17)23-10-12-6-7-12/h1-3,8,11-12H,4-7,9-10H2,(H2,22,23,25,26)	QEJQVKBULWEUGT-UHFFFAOYSA-N	280260	US10028961, Compound 419::US10172864, Compound 419::US10946023, Compound 419	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280260	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280260&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817553	378161809							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
618118	FC(F)(F)c1cncc(n1)-c1nc(NC2CCC(F)(F)CC2)cc(NC2CCC(F)(F)CC2)n1	InChI=1S/C21H23F7N6/c22-19(23)5-1-12(2-6-19)30-16-9-17(31-13-3-7-20(24,25)8-4-13)34-18(33-16)14-10-29-11-15(32-14)21(26,27)28/h9-13H,1-8H2,(H2,30,31,33,34)	UGJNNXSKMGDBMZ-UHFFFAOYSA-N	280262	US10028961, Compound 421::US10172864, Compound 421::US10946023, Compound 421	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2ZK5JQ3		aid1796522	US10172864	Konteatis, ZD; Popovici-Muller, J; Travins, JM; Zahler, R; Cai, Z; Zhou, D	1/8/2019	4/30/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=280262	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=280262&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			117817529	378161811							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621226	Clc1ccc2[nH]c(=O)c(CNc3cccc4ocnc34)cc2c1	InChI=1S/C17H12ClN3O2/c18-12-4-5-13-10(7-12)6-11(17(22)21-13)8-19-14-2-1-3-15-16(14)20-9-23-15/h1-7,9,19H,8H2,(H,21,22)	KDDSLGQLOSBLFG-UHFFFAOYSA-N	317486	US9624175, Compound I-1::3-{[(1,3-benzoxazol-4-yl)amino]methyl}-6-chloro-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317486	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317486&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374230	384220802							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621228	Cn1c2cc(NCc3cc4cc(Cl)ccc4[nH]c3=O)ccc2oc1=O	InChI=1S/C18H14ClN3O3/c1-22-15-8-13(3-5-16(15)25-18(22)24)20-9-11-6-10-7-12(19)2-4-14(10)21-17(11)23/h2-8,20H,9H2,1H3,(H,21,23)	WQLJTPQQDDWBQO-UHFFFAOYSA-N	317487	US9624175, Compound I-2::6-chloro-3-{[(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317487&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374231	384220803							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621229	Clc1ccc2[nH]c(=O)c(CNc3ccc4oc(=O)[nH]c4c3)cc2c1	InChI=1S/C17H12ClN3O3/c18-11-1-3-13-9(6-11)5-10(16(22)20-13)8-19-12-2-4-15-14(7-12)21-17(23)24-15/h1-7,19H,8H2,(H,20,22)(H,21,23)	IZMZMGUSJJVYHV-UHFFFAOYSA-N	317488	US9624175, Compound I-3::6-chloro-3-{[(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317488&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374232	384220804							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621230	Clc1ccc2[nH]c(=O)c(CNc3ccc4oc(=O)ccc4c3)cc2c1	InChI=1S/C19H13ClN2O3/c20-14-2-4-16-12(8-14)7-13(19(24)22-16)10-21-15-3-5-17-11(9-15)1-6-18(23)25-17/h1-9,21H,10H2,(H,22,24)	WCOWJEDCPKYVCN-UHFFFAOYSA-N	317489	US9624175, Compound I-4::6-chloro-3-{[(2-oxo-2H-chromen-6-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317489&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374233	384220805							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621232	CN1C(=O)CCc2cc(NCc3cc4cc(Cl)ccc4[nH]c3=O)ccc12	InChI=1S/C20H18ClN3O2/c1-24-18-6-4-16(10-12(18)2-7-19(24)25)22-11-14-8-13-9-15(21)3-5-17(13)23-20(14)26/h3-6,8-10,22H,2,7,11H2,1H3,(H,23,26)	MHXFRINSUKTDJU-UHFFFAOYSA-N	317490	US9624175, Compound I-5::6-chloro-3-{[(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317490&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374234	384220806							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621233	Clc1ccc2[nH]c(=O)c(CNc3cc4ccccc4cn3)cc2c1	InChI=1S/C19H14ClN3O/c20-16-5-6-17-14(8-16)7-15(19(24)23-17)11-22-18-9-12-3-1-2-4-13(12)10-21-18/h1-10H,11H2,(H,21,22)(H,23,24)	AAWQDHGACBLMOZ-UHFFFAOYSA-N	317491	US9624175, Compound I-6::6-chloro-3-{[(isoquinolin-3-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317491	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317491&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374235	384220807							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621234	Clc1ccc2[nH]c(=O)c(CNc3ccc(C#N)c4ccccc34)cc2c1	InChI=1S/C21H14ClN3O/c22-16-6-8-19-14(10-16)9-15(21(26)25-19)12-24-20-7-5-13(11-23)17-3-1-2-4-18(17)20/h1-10,24H,12H2,(H,25,26)	FEMIXYRIKWXAGW-UHFFFAOYSA-N	317492	US9624175, Compound I-7::4-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}naphthalene-1-carbonitrile	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317492&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374236	384220808							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621235	Clc1ccc2[nH]c(=O)c(CNc3cccc4cccnc34)cc2c1	InChI=1S/C19H14ClN3O/c20-15-6-7-16-13(10-15)9-14(19(24)23-16)11-22-17-5-1-3-12-4-2-8-21-18(12)17/h1-10,22H,11H2,(H,23,24)	AMAKPLGTKXQINO-UHFFFAOYSA-N	317493	US9624175, Compound I-8::6-chloro-3-{[(quinolin-8-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317493&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374237	384220809							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621236	Clc1ccc2[nH]c(=O)c(CNc3cccc4CCOc34)cc2c1	InChI=1S/C18H15ClN2O2/c19-14-4-5-15-12(9-14)8-13(18(22)21-15)10-20-16-3-1-2-11-6-7-23-17(11)16/h1-5,8-9,20H,6-7,10H2,(H,21,22)	RENWACLQSUZJBJ-UHFFFAOYSA-N	317494	US9624175, Compound I-9::6-chloro-3-{[(2,3-dihydro-1-benzofuran-7-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317494	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317494&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374238	384220810							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621237	CN1C(=O)COc2cc(NCc3cc4cc(Cl)ccc4[nH]c3=O)ccc12	InChI=1S/C19H16ClN3O3/c1-23-16-5-3-14(8-17(16)26-10-18(23)24)21-9-12-6-11-7-13(20)2-4-15(11)22-19(12)25/h2-8,21H,9-10H2,1H3,(H,22,25)	GRQGSHZYDGFAON-UHFFFAOYSA-N	317495	US9624175, Compound I-10::7-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-3-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317495&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374239	384220811							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621238	Clc1ccc2[nH]c(=O)c(CNc3ccc4NC(=O)COc4c3)cc2c1	InChI=1S/C18H14ClN3O3/c19-12-1-3-14-10(6-12)5-11(18(24)22-14)8-20-13-2-4-15-16(7-13)25-9-17(23)21-15/h1-7,20H,8-9H2,(H,21,23)(H,22,24)	WCLBHZCAEXTZLJ-UHFFFAOYSA-N	317496	US9624175, Compound I-11::7-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-3-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317496	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317496&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374240	384220812							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621239	COc1cc2cc(CNc3ccc4[nH]c(nc4c3)-c3ccc4[nH]cnc4c3)c(=O)[nH]c2cc1OC	InChI=1S/C26H22N6O3/c1-34-23-9-15-7-16(26(33)32-20(15)11-24(23)35-2)12-27-17-4-6-19-22(10-17)31-25(30-19)14-3-5-18-21(8-14)29-13-28-18/h3-11,13,27H,12H2,1-2H3,(H,28,29)(H,30,31)(H,32,33)	IDUHUDZNHJJBKQ-UHFFFAOYSA-N	317497	US9624175, Compound I-12::3-({[2-(1H-1,3-benzodiazol-5-yl)-1H-1,3-benzodiazol-5-yl]amino}methyl)-6,7-dimethoxy-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317497	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317497&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374241	384220813							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621240	Clc1ccc2[nH]c(=O)c(CNc3ccc4CC(=O)Nc4c3)cc2c1	InChI=1S/C18H14ClN3O2/c19-13-2-4-15-11(6-13)5-12(18(24)22-15)9-20-14-3-1-10-7-17(23)21-16(10)8-14/h1-6,8,20H,7,9H2,(H,21,23)(H,22,24)	PRWGOPRKGFLPJU-UHFFFAOYSA-N	317498	US9624175, Compound I-13::6-chloro-3-{[(2-oxo-2,3-dihydro-1H-indol-6-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317498	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317498&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374242	384220814							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621241	Cn1c2ccc(NCc3cc4cc(Cl)ccc4[nH]c3=O)cc2oc1=O	InChI=1S/C18H14ClN3O3/c1-22-15-5-3-13(8-16(15)25-18(22)24)20-9-11-6-10-7-12(19)2-4-14(10)21-17(11)23/h2-8,20H,9H2,1H3,(H,21,23)	BPYLTNJKTRFYJV-UHFFFAOYSA-N	317499	US9624175, Compound I-14::6-chloro-3-{[(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317499	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317499&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374243	384220815							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621242	Clc1ccc2[nH]c(=O)c(CNc3cccc4ccncc34)cc2c1	InChI=1S/C19H14ClN3O/c20-15-4-5-17-13(9-15)8-14(19(24)23-17)10-22-18-3-1-2-12-6-7-21-11-16(12)18/h1-9,11,22H,10H2,(H,23,24)	KPJDXQZEDZMIIN-UHFFFAOYSA-N	317500	US9624175, Compound I-15::6-chloro-3-{[(isoquinolin-8-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317500	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317500&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374244	384220816							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621243	Clc1ccc2[nH]c(=O)c(CNc3cccc4CCCOc34)cc2c1	InChI=1S/C19H17ClN2O2/c20-15-6-7-16-13(10-15)9-14(19(23)22-16)11-21-17-5-1-3-12-4-2-8-24-18(12)17/h1,3,5-7,9-10,21H,2,4,8,11H2,(H,22,23)	NSWSEWGMEILMFK-UHFFFAOYSA-N	317501	US9624175, Compound I-16::6-chloro-3-{[(3,4-dihydro-2H-1-benzopyran-8-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317501&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374245	384220817							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621244	COc1cc2CCC(=O)Nc2cc1NCc1cc2cc(Cl)ccc2[nH]c1=O	InChI=1S/C20H18ClN3O3/c1-27-18-8-11-2-5-19(25)23-16(11)9-17(18)22-10-13-6-12-7-14(21)3-4-15(12)24-20(13)26/h3-4,6-9,22H,2,5,10H2,1H3,(H,23,25)(H,24,26)	FLDZXLMCNGCRLR-UHFFFAOYSA-N	317502	US9624175, Compound I-17::6-chloro-3-{[(6-methoxy-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317502	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317502&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374246	384220818							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621245	Clc1ccc2[nH]c(=O)c(CNc3ccc4CCC(=O)Nc4c3)cc2c1	InChI=1S/C19H16ClN3O2/c20-14-3-5-16-12(8-14)7-13(19(25)23-16)10-21-15-4-1-11-2-6-18(24)22-17(11)9-15/h1,3-5,7-9,21H,2,6,10H2,(H,22,24)(H,23,25)	VVFDQPFSBHQVCG-UHFFFAOYSA-N	317503	US9624175, Compound I-18::6-chloro-3-{[(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317503&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374247	384220819							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621246	Cc1n[nH]c2cc(NCc3cc4cc(Cl)ccc4[nH]c3=O)ccc12	InChI=1S/C18H15ClN4O/c1-10-15-4-3-14(8-17(15)23-22-10)20-9-12-6-11-7-13(19)2-5-16(11)21-18(12)24/h2-8,20H,9H2,1H3,(H,21,24)(H,22,23)	RYNWPZQXUKLJAD-UHFFFAOYSA-N	317504	US9624175, Compound I-19::6-chloro-3-{[(3-methyl-1H-indazol-6-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317504&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374248	384220820							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621247	Clc1ccc2[nH]c(=O)c(CNc3ccc4NC(=O)CCc4c3)cc2c1	InChI=1S/C19H16ClN3O2/c20-14-2-4-17-12(8-14)7-13(19(25)23-17)10-21-15-3-5-16-11(9-15)1-6-18(24)22-16/h2-5,7-9,21H,1,6,10H2,(H,22,24)(H,23,25)	XQMNVGQHEFYUKQ-UHFFFAOYSA-N	317505	US9624175, Compound I-20::6-chloro-3-{[(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317505	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317505&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374249	384220821							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621248	COc1ccc2[nH]c(=O)c(CNc3ccc4sc(C)nc4c3)cc2c1	InChI=1S/C19H17N3O2S/c1-11-21-17-9-14(3-6-18(17)25-11)20-10-13-7-12-8-15(24-2)4-5-16(12)22-19(13)23/h3-9,20H,10H2,1-2H3,(H,22,23)	MFJGXPWRYDNMES-UHFFFAOYSA-N	317506	US9624175, Compound I-21::6-methoxy-3-{[(2-methyl-1,3-benzothiazol-5-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317506	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317506&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374250	384220822							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621249	Clc1ccc2[nH]c(=O)c(CNc3cccc4C(=O)CCCc34)cc2c1	InChI=1S/C20H17ClN2O2/c21-14-7-8-17-12(10-14)9-13(20(25)23-17)11-22-18-5-1-4-16-15(18)3-2-6-19(16)24/h1,4-5,7-10,22H,2-3,6,11H2,(H,23,25)	GLHQFZINOSCNKG-UHFFFAOYSA-N	317507	US9624175, Compound I-22::6-chloro-3-{[(5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317507	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317507&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374251	384220823							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621250	Clc1ccc2[nH]c(=O)c(CNc3ccc4nncn4n3)cc2c1	InChI=1S/C15H11ClN6O/c16-11-1-2-12-9(6-11)5-10(15(23)19-12)7-17-13-3-4-14-20-18-8-22(14)21-13/h1-6,8H,7H2,(H,17,21)(H,19,23)	CLVUANNPXJRMQO-UHFFFAOYSA-N	317508	US9624175, Compound I-23::6-chloro-3-[({[1,2,4]triazolo[4,3-b]pyridazin-6-yl}amino)methyl]-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317508	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317508&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374252	384220824							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621251	Clc1ccc2[nH]c(=O)c(CNc3ccc4[nH]cnc4c3)cc2c1	InChI=1S/C17H13ClN4O/c18-12-1-3-14-10(6-12)5-11(17(23)22-14)8-19-13-2-4-15-16(7-13)21-9-20-15/h1-7,9,19H,8H2,(H,20,21)(H,22,23)	ASNSVXBYFVMKGV-UHFFFAOYSA-N	317509	US9624175, Compound I-24::3-{[(1H-1,3-benzodiazol-5-yl)amino]methyl}-6-chloro-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317509&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374253	384220825							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621252	Clc1ccc2[nH]c(=O)c(CNc3ccc4cn[nH]c4c3)cc2c1	InChI=1S/C17H13ClN4O/c18-13-2-4-15-11(6-13)5-12(17(23)21-15)8-19-14-3-1-10-9-20-22-16(10)7-14/h1-7,9,19H,8H2,(H,20,22)(H,21,23)	RNUMHONQTIYXJR-UHFFFAOYSA-N	317510	US9624175, Compound I-25::6-chloro-3-{[(1H-indazol-6-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317510&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374254	384220826							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621253	Clc1ccc2[nH]c(=O)c(CNc3ccc4ncsc4c3)cc2c1	InChI=1S/C17H12ClN3OS/c18-12-1-3-14-10(6-12)5-11(17(22)21-14)8-19-13-2-4-15-16(7-13)23-9-20-15/h1-7,9,19H,8H2,(H,21,22)	FGIQXEPGIRLQGF-UHFFFAOYSA-N	317511	US9624175, Compound I-26::3-{[(1,3-benzothiazol-6-yl)amino]methyl}-6-chloro-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317511	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317511&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374255	384220827							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621254	Clc1ccc2[nH]c(=O)c(CNc3ccc4ncccc4c3)cc2c1	InChI=1S/C19H14ClN3O/c20-15-3-5-18-13(9-15)8-14(19(24)23-18)11-22-16-4-6-17-12(10-16)2-1-7-21-17/h1-10,22H,11H2,(H,23,24)	ZUFBZRNHVARGPY-UHFFFAOYSA-N	317512	US9624175, Compound I-27::6-chloro-3-{[(quinolin-6-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317512&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374256	384220828							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621255	FC(F)(F)c1nc2cc(NCc3cc4cc(Cl)ccc4[nH]c3=O)ccc2[nH]1	InChI=1S/C18H12ClF3N4O/c19-11-1-3-13-9(6-11)5-10(16(27)24-13)8-23-12-2-4-14-15(7-12)26-17(25-14)18(20,21)22/h1-7,23H,8H2,(H,24,27)(H,25,26)	NLKNRFMABJBYBJ-UHFFFAOYSA-N	317513	US9624175, Compound I-28::6-chloro-3-({[2-(trifluoromethyl)-1H-1,3-benzodiazol-5-yl]amino}methyl)-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317513&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374257	384220829							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621256	Clc1ccc2[nH]c(=O)c(CNc3ccc4scnc4c3)cc2c1	InChI=1S/C17H12ClN3OS/c18-12-1-3-14-10(6-12)5-11(17(22)21-14)8-19-13-2-4-16-15(7-13)20-9-23-16/h1-7,9,19H,8H2,(H,21,22)	TWXCGENAPFUQCC-UHFFFAOYSA-N	317514	US9624175, Compound I-29::3-{[(1,3-benzothiazol-5-yl)amino]methyl}-6-chloro-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317514&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374258	384220830							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621257	COc1ccc2[nH]c(=O)c(CNc3ccc4OCCOc4c3)cc2c1	InChI=1S/C19H18N2O4/c1-23-15-3-4-16-12(9-15)8-13(19(22)21-16)11-20-14-2-5-17-18(10-14)25-7-6-24-17/h2-5,8-10,20H,6-7,11H2,1H3,(H,21,22)	IZHUMFOCHVANLO-UHFFFAOYSA-N	317515	US9624175, Compound I-30::3-{[(2,3-dihydro-1,4-benzodioxin-6-yl)amino]methyl}-6-methoxy-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317515&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			78208315	384220831							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621258	Cc1cc2cc(CNc3ccc4cn[nH]c4c3)c(=O)[nH]c2cc1C	InChI=1S/C19H18N4O/c1-11-5-14-7-15(19(24)22-17(14)6-12(11)2)9-20-16-4-3-13-10-21-23-18(13)8-16/h3-8,10,20H,9H2,1-2H3,(H,21,23)(H,22,24)	SZJYHYGRGZHHAR-UHFFFAOYSA-N	317516	US9624175, Compound I-31::3-{[(1H-indazol-6-yl)amino]methyl}-6,7-dimethyl-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317516&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374259	384220832							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621259	Cc1ccc2cc(NCc3cc4cc(Cl)ccc4[nH]c3=O)ccc2n1	InChI=1S/C20H16ClN3O/c1-12-2-3-13-10-17(5-7-18(13)23-12)22-11-15-8-14-9-16(21)4-6-19(14)24-20(15)25/h2-10,22H,11H2,1H3,(H,24,25)	MQYCBIVJSIKSJZ-UHFFFAOYSA-N	317517	US9624175, Compound I-32::6-chloro-3-{[(2-methylquinolin-6-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317517&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374260	384220833							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621260	Clc1ccc2[nH]c(=O)c(CNc3ccc4OCCOc4c3)cc2c1	InChI=1S/C18H15ClN2O3/c19-13-1-3-15-11(8-13)7-12(18(22)21-15)10-20-14-2-4-16-17(9-14)24-6-5-23-16/h1-4,7-9,20H,5-6,10H2,(H,21,22)	DBJZDQJRYKEWKG-UHFFFAOYSA-N	317518	US9624175, Compound I-33::6-chloro-3-{[(2,3-dihydro-1,4-benzodioxin-6-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317518&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374261	384220834							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621261	COc1ccc2[nH]c(=O)c(CNc3ccc4cn[nH]c4c3)cc2c1	InChI=1S/C18H16N4O2/c1-24-15-4-5-16-12(7-15)6-13(18(23)21-16)9-19-14-3-2-11-10-20-22-17(11)8-14/h2-8,10,19H,9H2,1H3,(H,20,22)(H,21,23)	ZZDIBWBCJOLTMZ-UHFFFAOYSA-N	317519	US9624175, Compound I-34::3-{[(1H-indazol-6-yl)amino]methyl}-6-methoxy-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317519&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374262	384220835							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621262	COc1ccc2[nH]c(=O)c(CNc3ccc4nc(C)ccc4c3)cc2c1	InChI=1S/C21H19N3O2/c1-13-3-4-14-10-17(5-7-19(14)23-13)22-12-16-9-15-11-18(26-2)6-8-20(15)24-21(16)25/h3-11,22H,12H2,1-2H3,(H,24,25)	JVYCHBLRCJHCGO-UHFFFAOYSA-N	317520	US9624175, Compound I-35::6-methoxy-3-{[(2-methylquinolin-6-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317520&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374263	384220836							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621263	COc1ccc2[nH]c(=O)c(CNc3ccc4ncsc4c3)cc2c1	InChI=1S/C18H15N3O2S/c1-23-14-3-5-15-11(7-14)6-12(18(22)21-15)9-19-13-2-4-16-17(8-13)24-10-20-16/h2-8,10,19H,9H2,1H3,(H,21,22)	NYLXEDFYFHIHRB-UHFFFAOYSA-N	317521	US9624175, Compound I-36::3-{[(1,3-benzothiazol-6-yl)amino]methyl}-6-methoxy-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317521&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374264	384220837							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621264	Cc1ccc2cc(NCc3cc4cc(C)c(C)cc4[nH]c3=O)ccc2n1	InChI=1S/C22H21N3O/c1-13-8-17-10-18(22(26)25-21(17)9-14(13)2)12-23-19-6-7-20-16(11-19)5-4-15(3)24-20/h4-11,23H,12H2,1-3H3,(H,25,26)	ZQWQZZZGBOADDA-UHFFFAOYSA-N	317522	US9624175, Compound I-37::6,7-dimethyl-3-{[(2-methylquinolin-6-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317522&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374265	384220838							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621265	Clc1ccc2[nH]c(=O)c(CNc3ccc4[nH]ncc4c3)cc2c1	InChI=1S/C17H13ClN4O/c18-13-1-3-15-10(6-13)5-12(17(23)21-15)8-19-14-2-4-16-11(7-14)9-20-22-16/h1-7,9,19H,8H2,(H,20,22)(H,21,23)	REEQBRVZEDNIMU-UHFFFAOYSA-N	317523	US9624175, Compound I-38::6-chloro-3-{[(1H-indazol-5-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317523	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317523&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374266	384220839							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621266	COc1ccc2[nH]c(=O)c(CNc3ccc4ncccc4c3)cc2c1	InChI=1S/C20H17N3O2/c1-25-17-5-7-19-14(11-17)9-15(20(24)23-19)12-22-16-4-6-18-13(10-16)3-2-8-21-18/h2-11,22H,12H2,1H3,(H,23,24)	FCEIPKUSWIJUND-UHFFFAOYSA-N	317524	US9624175, Compound I-39::6-methoxy-3-{[(quinolin-6-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317524	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317524&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374267	384220840							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621267	Cc1cc2cc(CNc3ccc4ncsc4c3)c(=O)[nH]c2cc1C	InChI=1S/C19H17N3OS/c1-11-5-13-7-14(19(23)22-17(13)6-12(11)2)9-20-15-3-4-16-18(8-15)24-10-21-16/h3-8,10,20H,9H2,1-2H3,(H,22,23)	OZTISACMRPJGFO-UHFFFAOYSA-N	317525	US9624175, Compound I-40::3-{[(1,3-benzothiazol-6-yl)amino]methyl}-6,7-dimethyl-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317525&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374268	384220841							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621268	CC(C)(C)c1ccc2[nH]c(=O)c(CNc3ccc4[nH]ncc4c3)cc2c1	InChI=1S/C21H22N4O/c1-21(2,3)16-4-6-18-13(9-16)8-15(20(26)24-18)11-22-17-5-7-19-14(10-17)12-23-25-19/h4-10,12,22H,11H2,1-3H3,(H,23,25)(H,24,26)	ILNHUHMYROKLAV-UHFFFAOYSA-N	317526	US9624175, Compound I-41::6-tert-butyl-3-{[(1H-indazol-5-yl)amino]methyl}-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317526&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			74472946	384220842							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621269	C[C@H](Nc1nccc2N(CCc12)C(C)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H19ClN4O2/c1-11(16-10-13-9-14(21)3-4-17(13)24-20(16)27)23-19-15-6-8-25(12(2)26)18(15)5-7-22-19/h3-5,7,9-11H,6,8H2,1-2H3,(H,22,23)(H,24,27)	OYBWNNMYHQWGDX-UHFFFAOYSA-N	317527	US9624175, Compound I-42::3-[(1S)-1-({1-acetyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-4-yl}amino)ethyl]-6-chloro-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317527&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374269	384220843							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621271	C[C@H](Nc1nccc2N(CCc12)S(C)(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H19ClN4O3S/c1-11(15-10-12-9-13(20)3-4-16(12)23-19(15)25)22-18-14-6-8-24(28(2,26)27)17(14)5-7-21-18/h3-5,7,9-11H,6,8H2,1-2H3,(H,21,22)(H,23,25)	CFZKDRDHWOSBEH-UHFFFAOYSA-N	317528	US9624175, Compound I-43::6-chloro-3-[(1S)-1-({1-methanesulfonyl-1H,2H,3H-pyrrolo[3,2-c]pyridin-4-yl}amino)ethyl]-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317528&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374270	384220844							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621272	C[C@H](Nc1nccc2N(CCOc12)C(C)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H19ClN4O3/c1-11(15-10-13-9-14(21)3-4-16(13)24-20(15)27)23-19-18-17(5-6-22-19)25(12(2)26)7-8-28-18/h3-6,9-11H,7-8H2,1-2H3,(H,22,23)(H,24,27)	XJNPVEZQLFGOMC-UHFFFAOYSA-N	317529	US9624175, Compound I-44::3-[(1S)-1-({1-acetyl-1H,2H,3H-pyrido[3,4-b][1,4]oxazin-5-yl}amino)ethyl]-6-chloro-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317529&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374271	384220845							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621274	C[C@H](Nc1ncc2cn[nH]c2n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C16H13ClN6O/c1-8(20-16-18-6-10-7-19-23-14(10)22-16)12-5-9-4-11(17)2-3-13(9)21-15(12)24/h2-8H,1H3,(H,21,24)(H2,18,19,20,22,23)	JYWGNEROAYIITB-UHFFFAOYSA-N	317530	US9624175, Compound I-45::6-chloro-3-[(1S)-1-({1H-pyrazolo[3,4-d]pyrimidin-6-yl}amino)ethyl]-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317530&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374272	384220846							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621276	CC(C)CN1C(=O)OCc2cnc(N[C@@H](C)c3cc4cc(Cl)ccc4[nH]c3=O)nc12 |r|	InChI=1S/C21H22ClN5O3/c1-11(2)9-27-18-14(10-30-21(27)29)8-23-20(26-18)24-12(3)16-7-13-6-15(22)4-5-17(13)25-19(16)28/h4-8,11-12H,9-10H2,1-3H3,(H,25,28)(H,23,24,26)	UATPDOGSKPZAMC-UHFFFAOYSA-N	317531	US9624175, Compound I-46::6-chloro-3-[(1S)-1-{[1-(2-methylpropyl)-2-oxo-1H,2H,4H-pyrimido[4,5-d][1,3]oxazin-7-yl]amino}ethyl]-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<100							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317531&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374273	384220847							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621278	C[C@H](Nc1ncc2COC(=O)N(C)c2n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H16ClN5O3/c1-9(13-6-10-5-12(19)3-4-14(10)22-16(13)25)21-17-20-7-11-8-27-18(26)24(2)15(11)23-17/h3-7,9H,8H2,1-2H3,(H,22,25)(H,20,21,23)	WXQZFWGENNYCMD-UHFFFAOYSA-N	317532	US9624175, Compound I-47::6-chloro-3-[(1S)-1-({1-methyl-2-oxo-1H,2H,4H-pyrimido[4,5-d][1,3]oxazin-7-yl}amino)ethyl]-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<100							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317532	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317532&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374274	384220848							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621280	C[C@H](Nc1ncc2COC(=O)N(C)c2n1)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O |r|	InChI=1S/C24H21ClN6O4/c1-13(28-23-27-10-15-11-35-24(33)31(2)21(15)30-23)17-7-14-8-18(25)20(9-19(14)29-22(17)32)34-12-16-5-3-4-6-26-16/h3-10,13H,11-12H2,1-2H3,(H,29,32)(H,27,28,30)	ZZFKQHHJKDQASI-UHFFFAOYSA-N	317533	US9624175, Compound I-48::6-chloro-3-[(1S)-1-({1-methyl-2-oxo-1H,2H,4H-pyrimido[4,5-d][1,3]oxazin-7-yl}amino)ethyl]-7-(pyridin-2-ylmethoxy)-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<100							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317533&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374275	384220849							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621282	C[C@H](Nc1ncc2COC(=O)Nc2n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C17H14ClN5O3/c1-8(12-5-9-4-11(18)2-3-13(9)21-15(12)24)20-16-19-6-10-7-26-17(25)23-14(10)22-16/h2-6,8H,7H2,1H3,(H,21,24)(H2,19,20,22,23,25)	MLIVDCBRILJUSV-UHFFFAOYSA-N	317534	US9624175, Compound I-49::6-chloro-3-[(1S)-1-({2-oxo-1H,2H,4H-pyrimido[4,5-d][1,3]oxazin-7-yl}amino)ethyl]-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<100							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317534&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374276	384220850							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621284	COc1cc2[nH]c(=O)c(cc2cc1Cl)C(C)Nc1ncc2COC(=O)N(C)c2n1	InChI=1S/C19H18ClN5O4/c1-9(22-18-21-7-11-8-29-19(27)25(2)16(11)24-18)12-4-10-5-13(20)15(28-3)6-14(10)23-17(12)26/h4-7,9H,8H2,1-3H3,(H,23,26)(H,21,22,24)	LKAUCJOSAAZMOY-UHFFFAOYSA-N	317535	US9624175, Compound I-50::6-chloro-7-methoxy-3-[1-({1-methyl-2-oxo-1H,2H,4H-pyrimido[4,5-d][1,3]oxazin-7-yl}amino)ethyl]-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<100							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317535	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317535&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374277	384220851							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621286	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1ncc2COC(=O)N(C)c2n1 |r|	InChI=1S/C19H18ClN5O4/c1-9(22-18-21-7-11-8-29-19(27)25(2)16(11)24-18)12-4-10-5-13(20)15(28-3)6-14(10)23-17(12)26/h4-7,9H,8H2,1-3H3,(H,23,26)(H,21,22,24)	LKAUCJOSAAZMOY-UHFFFAOYSA-N	317536	US9624175, Compound I-51::6-chloro-7-methoxy-3-[(1S)-1-({1-methyl-2-oxo-1H,2H,4H-pyrimido[4,5-d][1,3]oxazin-7-yl}amino)ethyl]-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<100							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317536	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317536&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374278	384220852							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621288	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@@H](C)Nc1ncc2COC(=O)N(C)c2n1 |r|	InChI=1S/C19H18ClN5O4/c1-9(22-18-21-7-11-8-29-19(27)25(2)16(11)24-18)12-4-10-5-13(20)15(28-3)6-14(10)23-17(12)26/h4-7,9H,8H2,1-3H3,(H,23,26)(H,21,22,24)	LKAUCJOSAAZMOY-UHFFFAOYSA-N	317537	US9624175, Compound I-52::6-chloro-7-methoxy-3-[(1R)-1-({1-methyl-2-oxo-1H,2H,4H-pyrimido[4,5-d][1,3]oxazin-7-yl}amino)ethyl]-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317537&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374279	384220853							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621290	C[C@@H](Nc1ncc2COC(=O)N(C)c2n1)c1cc2cc(Cl)c(F)cc2[nH]c1=O |r|	InChI=1S/C18H15ClFN5O3/c1-8(11-3-9-4-12(19)13(20)5-14(9)23-16(11)26)22-17-21-6-10-7-28-18(27)25(2)15(10)24-17/h3-6,8H,7H2,1-2H3,(H,23,26)(H,21,22,24)	ZSJLAUNDZPKNJX-UHFFFAOYSA-N	317538	US9624175, Compound I-53::6-chloro-7-fluoro-3-[(1R)-1-({1-methyl-2-oxo-1H,2H,4H-pyrimido[4,5-d][1,3]oxazin-7-yl}amino)ethyl]-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317538&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374280	384220854							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621292	CC(C)Cn1c2nc(N[C@@H](C)c3cc4cc(Cl)ccc4[nH]c3=O)ncc2oc1=O |r|	InChI=1S/C20H20ClN5O3/c1-10(2)9-26-17-16(29-20(26)28)8-22-19(25-17)23-11(3)14-7-12-6-13(21)4-5-15(12)24-18(14)27/h4-8,10-11H,9H2,1-3H3,(H,24,27)(H,22,23,25)	KHOMFNXABGBFDA-UHFFFAOYSA-N	317539	US9624175, Compound I-55::6-chloro-3-[(1S)-1-{[3-(2-methylpropyl)-2-oxo-2H,3H-[1,3]oxazolo[4,5-d]pyrimidin-5-yl]amino}ethyl]-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<100							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317539	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317539&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374281	384220855							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621294	C[C@H](Nc1ncc2oc(=O)[nH]c2n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C16H12ClN5O3/c1-7(19-15-18-6-12-13(21-15)22-16(24)25-12)10-5-8-4-9(17)2-3-11(8)20-14(10)23/h2-7H,1H3,(H,20,23)(H2,18,19,21,22,24)	KGJNSPAFTAUTKU-UHFFFAOYSA-N	317540	US9624175, Compound I-56::6-chloro-3-[(1S)-1-({2-oxo-2H,3H-[1,3]oxazolo[4,5-d]pyrimidin-5-yl}amino)ethyl]-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<100							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317540&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374282	384220856							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621296	C[C@H](Nc1ncc2oc(=O)n(C)c2n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C17H14ClN5O3/c1-8(11-6-9-5-10(18)3-4-12(9)21-15(11)24)20-16-19-7-13-14(22-16)23(2)17(25)26-13/h3-8H,1-2H3,(H,21,24)(H,19,20,22)	ACXYMKPPPNPXMY-UHFFFAOYSA-N	317541	US9624175, Compound I-57::6-chloro-3-[(1S)-1-({3-methyl-2-oxo-2H,3H-[1,3]oxazolo[4,5-d]pyrimidin-5-yl}amino)ethyl]-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<100							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317541&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374283	384220857							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621298	C[C@H](Nc1ncc2[nH]c(=O)n(C)c2n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C17H15ClN6O2/c1-8(11-6-9-5-10(18)3-4-12(9)21-15(11)25)20-16-19-7-13-14(23-16)24(2)17(26)22-13/h3-8H,1-2H3,(H,21,25)(H,22,26)(H,19,20,23)	OOFPFXKRMDPOCN-UHFFFAOYSA-N	317542	US9624175, Compound I-58::6-chloro-3-[(1S)-1-[(9-methyl-8-oxo-8,9-dihydro-7H-purin-2-yl)amino]ethyl]-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317542	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317542&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374284	384220858							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621300	C[C@H](Nc1ncc2[nH]c(=O)[nH]c2n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C16H13ClN6O2/c1-7(19-15-18-6-12-13(22-15)23-16(25)21-12)10-5-8-4-9(17)2-3-11(8)20-14(10)24/h2-7H,1H3,(H,20,24)(H3,18,19,21,22,23,25)	SAUKYBSPNNEAIC-UHFFFAOYSA-N	317543	US9624175, Compound I-59::6-chloro-3-[(1S)-1-[(8-oxo-8,9-dihydro-7H-purin-2-yl)amino]ethyl]-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317543&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374285	384220859							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621302	C[C@H](Nc1ncc2CC(=O)Nc2n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C17H14ClN5O2/c1-8(20-17-19-7-10-6-14(24)22-15(10)23-17)12-5-9-4-11(18)2-3-13(9)21-16(12)25/h2-5,7-8H,6H2,1H3,(H,21,25)(H2,19,20,22,23,24)	SVZCBBHNJDGDJN-UHFFFAOYSA-N	317544	US9624175, Compound I-60::6-chloro-3-[(1S)-1-({6-oxo-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317544&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374286	384220860							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621304	C[C@H](Nc1ncc2CC(=O)N(C)c2n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H16ClN5O2/c1-9(13-6-10-5-12(19)3-4-14(10)22-17(13)26)21-18-20-8-11-7-15(25)24(2)16(11)23-18/h3-6,8-9H,7H2,1-2H3,(H,22,26)(H,20,21,23)	PUPSAJIRJWJXQC-UHFFFAOYSA-N	317545	US9624175, Compound I-61::6-chloro-3-[(1S)-1-({7-methyl-6-oxo-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 550							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317545&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374287	384220861							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
621306	C[C@H](Nc1ncc2CCC(=O)Nc2n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H16ClN5O2/c1-9(13-7-11-6-12(19)3-4-14(11)22-17(13)26)21-18-20-8-10-2-5-15(25)23-16(10)24-18/h3-4,6-9H,2,5H2,1H3,(H,22,26)(H2,20,21,23,24,25)	JGJGZNSHIGQNKG-UHFFFAOYSA-N	317546	US9624175, Compound I-62::6-chloro-3-[(1S)-1-({7-oxo-5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-2-yl}amino)ethyl]-1,2-dihydroquinolin-2-one	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2M61NB0		aid1796568	US9624175	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/18/2017	5/15/2019	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=317546	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=317546&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138374288	384220862							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630062	COC(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(nc2c1)-c1ccc(OC(F)(F)F)cc1	InChI=1S/C25H27F3N2O3/c1-15-11-18(14-24(2,3)13-15)30-21-10-7-17(23(31)32-4)12-20(21)29-22(30)16-5-8-19(9-6-16)33-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3/t15-,18+/m0/s1	RMALWUZGRQDPSA-MAUKXSAKSA-N	321170	(+-) methyl 2-[4-(trifluoromethoxy)phenyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylate::US10179123, Example 2-1::US10179123, Example 2-1-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 9900							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321170	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321170&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187974	384224274							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630063	COC(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(nc2c1)-c1ccc(OC(F)(F)F)cc1	InChI=1S/C25H27F3N2O3/c1-15-11-18(14-24(2,3)13-15)30-21-10-7-17(23(31)32-4)12-20(21)29-22(30)16-5-8-19(9-6-16)33-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3/t15-,18+/m0/s1	RMALWUZGRQDPSA-MAUKXSAKSA-N	321170	(+-) methyl 2-[4-(trifluoromethoxy)phenyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylate::US10179123, Example 2-1::US10179123, Example 2-1-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321170	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321170&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187974	384224274							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630064	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(nc2c1)-c1ccc(OC(F)(F)F)cc1	InChI=1S/C25H27F3N2O3/c1-15-11-18(14-24(2,3)13-15)30-21-10-7-17(23(31)32-4)12-20(21)29-22(30)16-5-8-19(9-6-16)33-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3/t15-,18+/m1/s1	RMALWUZGRQDPSA-QAPCUYQASA-N	321172	US10179123, Example 2-1-2::methyl 2-[4-(trifluoromethoxy)phenyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylate, Enantiomer B	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5700							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321172	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321172&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187973	384224275							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630065	C[C@H]1C[C@H](CC(C)(C)C1)n1c(nc2cc(ccc12)C(O)=O)-c1ccc(OC(F)(F)F)cc1	InChI=1S/C24H25F3N2O3/c1-14-10-17(13-23(2,3)12-14)29-20-9-6-16(22(30)31)11-19(20)28-21(29)15-4-7-18(8-5-15)32-24(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,30,31)/t14-,17+/m0/s1	YFTHPVPRANLTLO-WMLDXEAASA-N	321173	(+-) 2-[4-(trifluoromethoxy)phenyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylic Acid::US10179123, Example 2-2::US10179123, Example 2-2-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 190							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321173	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321173&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188126	384224276							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630066	C[C@H]1C[C@H](CC(C)(C)C1)n1c(nc2cc(ccc12)C(O)=O)-c1ccc(OC(F)(F)F)cc1	InChI=1S/C24H25F3N2O3/c1-14-10-17(13-23(2,3)12-14)29-20-9-6-16(22(30)31)11-19(20)28-21(29)15-4-7-18(8-5-15)32-24(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,30,31)/t14-,17+/m0/s1	YFTHPVPRANLTLO-WMLDXEAASA-N	321173	(+-) 2-[4-(trifluoromethoxy)phenyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylic Acid::US10179123, Example 2-2::US10179123, Example 2-2-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 130							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321173	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321173&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188126	384224276							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630067	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(nc2cc(ccc12)C(O)=O)-c1ccc(OC(F)(F)F)cc1	InChI=1S/C24H25F3N2O3/c1-14-10-17(13-23(2,3)12-14)29-20-9-6-16(22(30)31)11-19(20)28-21(29)15-4-7-18(8-5-15)32-24(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,30,31)/t14-,17+/m1/s1	YFTHPVPRANLTLO-PBHICJAKSA-N	321175	2-[4-(trifluoromethoxy)phenyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylic Acid, Enantiomer B::US10179123, Example 2-2-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 390							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321175	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321175&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188127	384224277							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630068	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Cc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C26H29F3N2O3/c1-16-11-19(15-25(2,3)14-16)31-22-10-7-18(24(32)33-4)13-21(22)30-23(31)12-17-5-8-20(9-6-17)34-26(27,28)29/h5-10,13,16,19H,11-12,14-15H2,1-4H3/t16-,19+/m1/s1	FLKIGLHBPCYBSL-APWZRJJASA-N	321176	(+-) methyl 2-[4-(trifluoromethoxy)benzyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylate::US10179123, Example 2-3::US10179123, Example 2-3-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 670							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321176	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321176&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188296	384224278							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630069	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Cc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C26H29F3N2O3/c1-16-11-19(15-25(2,3)14-16)31-22-10-7-18(24(32)33-4)13-21(22)30-23(31)12-17-5-8-20(9-6-17)34-26(27,28)29/h5-10,13,16,19H,11-12,14-15H2,1-4H3/t16-,19+/m1/s1	FLKIGLHBPCYBSL-APWZRJJASA-N	321176	(+-) methyl 2-[4-(trifluoromethoxy)benzyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylate::US10179123, Example 2-3::US10179123, Example 2-3-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1700							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321176	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321176&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188296	384224278							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630070	COC(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Cc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C26H29F3N2O3/c1-16-11-19(15-25(2,3)14-16)31-22-10-7-18(24(32)33-4)13-21(22)30-23(31)12-17-5-8-20(9-6-17)34-26(27,28)29/h5-10,13,16,19H,11-12,14-15H2,1-4H3/t16-,19+/m0/s1	FLKIGLHBPCYBSL-QFBILLFUSA-N	321178	US10179123, Example 2-3-2::methyl 2-[4-(trifluoromethoxy)benzyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylate, Enantiomer B	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 610							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321178	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321178&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188298	384224279							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630071	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Cc3ccc(OC(C)C)cc3)nc2c1	InChI=1S/C28H36N2O3/c1-18(2)33-23-10-7-20(8-11-23)14-26-29-24-15-21(27(31)32-6)9-12-25(24)30(26)22-13-19(3)16-28(4,5)17-22/h7-12,15,18-19,22H,13-14,16-17H2,1-6H3/t19-,22+/m1/s1	NHYHVCDCSVCJHS-KNQAVFIVSA-N	321179	US10179123, Example 2-6	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1500							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321179	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321179&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187971	384224280							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630072	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Cc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C28H36N2O2/c1-18(2)21-9-7-20(8-10-21)14-26-29-24-15-22(27(31)32-6)11-12-25(24)30(26)23-13-19(3)16-28(4,5)17-23/h7-12,15,18-19,23H,13-14,16-17H2,1-6H3/t19-,23+/m1/s1	UPHOKTXAJDRXHE-XXBNENTESA-N	321180	US10179123, Example 2-7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 330							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321180	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321180&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188183	384224281							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630073	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Cc3ccc(cc3)C(F)(F)F)nc2c1	InChI=1S/C26H29F3N2O2/c1-16-11-20(15-25(2,3)14-16)31-22-10-7-18(24(32)33-4)13-21(22)30-23(31)12-17-5-8-19(9-6-17)26(27,28)29/h5-10,13,16,20H,11-12,14-15H2,1-4H3/t16-,20+/m1/s1	ANXNZSTWNXTOIR-UZLBHIALSA-N	321181	US10179123, Example 2-8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1500							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321181	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321181&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188295	384224282							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630074	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Cc3ccc(F)cc3)nc2c1	InChI=1S/C25H29FN2O2/c1-16-11-20(15-25(2,3)14-16)28-22-10-7-18(24(29)30-4)13-21(22)27-23(28)12-17-5-8-19(26)9-6-17/h5-10,13,16,20H,11-12,14-15H2,1-4H3/t16-,20+/m1/s1	RNZZBXRDOXVTGK-UZLBHIALSA-N	321182	US10179123, Example 2-9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 4200							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321182	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321182&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188346	384224283							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630075	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Cc3ccc(C)cc3)nc2c1	InChI=1S/C26H32N2O2/c1-17-6-8-19(9-7-17)13-24-27-22-14-20(25(29)30-5)10-11-23(22)28(24)21-12-18(2)15-26(3,4)16-21/h6-11,14,18,21H,12-13,15-16H2,1-5H3/t18-,21+/m1/s1	XQZNUSJDVXYSQH-NQIIRXRSSA-N	321183	US10179123, Example 2-10	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1500							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321183	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321183&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188347	384224284							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630076	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Cc3ccc(cc3)C(C)(C)C)nc2c1	InChI=1S/C29H38N2O2/c1-19-14-23(18-29(5,6)17-19)31-25-13-10-21(27(32)33-7)16-24(25)30-26(31)15-20-8-11-22(12-9-20)28(2,3)4/h8-13,16,19,23H,14-15,17-18H2,1-7H3/t19-,23+/m1/s1	POORVELNUDMONW-XXBNENTESA-N	321184	US10179123, Example 2-11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1400							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321184	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321184&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188198	384224285							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630077	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Cc3ccccc3)nc2c1	InChI=1S/C25H30N2O2/c1-17-12-20(16-25(2,3)15-17)27-22-11-10-19(24(28)29-4)14-21(22)26-23(27)13-18-8-6-5-7-9-18/h5-11,14,17,20H,12-13,15-16H2,1-4H3/t17-,20+/m1/s1	CWMWYDYUCRBZSY-XLIONFOSSA-N	321185	US10179123, Example 2-12	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3500							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321185	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321185&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188270	384224286							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630078	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Cc3ccccc3OC(F)(F)F)nc2c1	InChI=1S/C26H29F3N2O3/c1-16-11-19(15-25(2,3)14-16)31-21-10-9-18(24(32)33-4)12-20(21)30-23(31)13-17-7-5-6-8-22(17)34-26(27,28)29/h5-10,12,16,19H,11,13-15H2,1-4H3/t16-,19+/m1/s1	WPAGQYMRQMCBLC-APWZRJJASA-N	321186	US10179123, Example 2-13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321186	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321186&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188302	384224287							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630079	COC(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Cc3cccc(OC(F)(F)F)c3)nc2c1	InChI=1S/C26H29F3N2O3/c1-16-10-19(15-25(2,3)14-16)31-22-9-8-18(24(32)33-4)13-21(22)30-23(31)12-17-6-5-7-20(11-17)34-26(27,28)29/h5-9,11,13,16,19H,10,12,14-15H2,1-4H3/t16-,19+/m0/s1	OZKJKJKJOFTLBY-QFBILLFUSA-N	321187	US10179123, Example 2-14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 10000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321187	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321187&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188305	384224288							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630080	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Cc3sc(nc3C)-c3ccccc3)nc2c1	InChI=1S/C29H33N3O2S/c1-18-13-22(17-29(3,4)16-18)32-24-12-11-21(28(33)34-5)14-23(24)31-26(32)15-25-19(2)30-27(35-25)20-9-7-6-8-10-20/h6-12,14,18,22H,13,15-17H2,1-5H3/t18-,22+/m1/s1	HROSPJKGYGMEKK-GCJKJVERSA-N	321188	US10179123, Example 2-15	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 8000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321188	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321188&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187965	384224289							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630081	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Cc3c(C)[nH]c4ccc(F)cc34)nc2c1 |r|	InChI=1S/C28H32FN3O2/c1-16-10-20(15-28(3,4)14-16)32-25-9-6-18(27(33)34-5)11-24(25)31-26(32)13-21-17(2)30-23-8-7-19(29)12-22(21)23/h6-9,11-12,16,20,30H,10,13-15H2,1-5H3	MOJVNQQJSKDCFL-UHFFFAOYSA-N	321189	US10179123, Example 2-16	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5800							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321189	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321189&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187966	384224290							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630082	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Cc3cn(C)c4ccccc34)nc2c1	InChI=1S/C28H33N3O2/c1-18-12-21(16-28(2,3)15-18)31-25-11-10-19(27(32)33-5)13-23(25)29-26(31)14-20-17-30(4)24-9-7-6-8-22(20)24/h6-11,13,17-18,21H,12,14-16H2,1-5H3/t18-,21+/m1/s1	JQFICDUBJHFAOY-NQIIRXRSSA-N	321190	US10179123, Example 2-17	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 9000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321190	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321190&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188311	384224291							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630083	COC(=O)c1cc2nc(Cc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1C	InChI=1S/C27H31F3N2O3/c1-16-10-19(15-26(3,4)14-16)32-23-11-17(2)21(25(33)34-5)13-22(23)31-24(32)12-18-6-8-20(9-7-18)35-27(28,29)30/h6-9,11,13,16,19H,10,12,14-15H2,1-5H3/t16-,19+/m1/s1	FQFWGPJTNVVXRJ-APWZRJJASA-N	321191	US10179123, Example 2-18::US10179123, Example 2-18-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 150							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321191	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321191&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187976	384224292							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630084	COC(=O)c1cc2nc(Cc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1C	InChI=1S/C27H31F3N2O3/c1-16-10-19(15-26(3,4)14-16)32-23-11-17(2)21(25(33)34-5)13-22(23)31-24(32)12-18-6-8-20(9-7-18)35-27(28,29)30/h6-9,11,13,16,19H,10,12,14-15H2,1-5H3/t16-,19+/m1/s1	FQFWGPJTNVVXRJ-APWZRJJASA-N	321191	US10179123, Example 2-18::US10179123, Example 2-18-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 140							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321191	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321191&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187976	384224292							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630085	COC(=O)c1cc2nc(Cc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1C	InChI=1S/C27H31F3N2O3/c1-16-10-19(15-26(3,4)14-16)32-23-11-17(2)21(25(33)34-5)13-22(23)31-24(32)12-18-6-8-20(9-7-18)35-27(28,29)30/h6-9,11,13,16,19H,10,12,14-15H2,1-5H3/t16-,19+/m0/s1	FQFWGPJTNVVXRJ-QFBILLFUSA-N	321193	US10179123, Example 2-18-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1200							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321193	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321193&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187977	384224293							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630086	COC(=O)c1cc2nc(Cc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C27H31F3N2O4/c1-16-10-18(15-26(2,3)14-16)32-22-13-23(34-4)20(25(33)35-5)12-21(22)31-24(32)11-17-6-8-19(9-7-17)36-27(28,29)30/h6-9,12-13,16,18H,10-11,14-15H2,1-5H3/t16-,18+/m0/s1	QMKVQYBWIHSCNN-FUHWJXTLSA-N	321194	US10179123, Example 2-19::US10179123, Example 2-19-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 160							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321194	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321194&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187958	384224294							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630087	COC(=O)c1cc2nc(Cc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C27H31F3N2O4/c1-16-10-18(15-26(2,3)14-16)32-22-13-23(34-4)20(25(33)35-5)12-21(22)31-24(32)11-17-6-8-19(9-7-17)36-27(28,29)30/h6-9,12-13,16,18H,10-11,14-15H2,1-5H3/t16-,18+/m1/s1	QMKVQYBWIHSCNN-AEFFLSMTSA-N	321195	US10179123, Example 2-19-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321195	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321195&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187957	384224295							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630088	COC(=O)c1cc2nc(Cc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C27H31F3N2O4/c1-16-10-18(15-26(2,3)14-16)32-22-13-23(34-4)20(25(33)35-5)12-21(22)31-24(32)11-17-6-8-19(9-7-17)36-27(28,29)30/h6-9,12-13,16,18H,10-11,14-15H2,1-5H3/t16-,18+/m0/s1	QMKVQYBWIHSCNN-FUHWJXTLSA-N	321194	US10179123, Example 2-19::US10179123, Example 2-19-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 70.0							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321194	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321194&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187958	384224294							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630089	COC(=O)c1cc2nc(Cc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC(C)C	InChI=1S/C29H35F3N2O4/c1-17(2)37-25-14-24-23(13-22(25)27(35)36-6)33-26(34(24)20-11-18(3)15-28(4,5)16-20)12-19-7-9-21(10-8-19)38-29(30,31)32/h7-10,13-14,17-18,20H,11-12,15-16H2,1-6H3/t18-,20+/m1/s1	HGCDDBCVHBMACR-QUCCMNQESA-N	321197	US10179123, Example 2-20::US10179123, Example 2-20-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2800							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321197	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321197&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187979	384224296							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630090	COC(=O)c1cc2nc(Cc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC(C)C	InChI=1S/C29H35F3N2O4/c1-17(2)37-25-14-24-23(13-22(25)27(35)36-6)33-26(34(24)20-11-18(3)15-28(4,5)16-20)12-19-7-9-21(10-8-19)38-29(30,31)32/h7-10,13-14,17-18,20H,11-12,15-16H2,1-6H3/t18-,20+/m1/s1	HGCDDBCVHBMACR-QUCCMNQESA-N	321197	US10179123, Example 2-20::US10179123, Example 2-20-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1300							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321197	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321197&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187979	384224296							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630091	COC(=O)c1cc2nc(Cc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1OC(C)C	InChI=1S/C29H35F3N2O4/c1-17(2)37-25-14-24-23(13-22(25)27(35)36-6)33-26(34(24)20-11-18(3)15-28(4,5)16-20)12-19-7-9-21(10-8-19)38-29(30,31)32/h7-10,13-14,17-18,20H,11-12,15-16H2,1-6H3/t18-,20+/m0/s1	HGCDDBCVHBMACR-AZUAARDMSA-N	321199	US10179123, Example 2-20-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3300							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321199	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321199&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187978	384224297							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630092	COC(=O)c1cc2nc(Cc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OCC(F)(F)F	InChI=1S/C28H30F6N2O4/c1-16-9-18(14-26(2,3)13-16)36-22-12-23(39-15-27(29,30)31)20(25(37)38-4)11-21(22)35-24(36)10-17-5-7-19(8-6-17)40-28(32,33)34/h5-8,11-12,16,18H,9-10,13-15H2,1-4H3/t16-,18+/m1/s1	OPRNNFKOYJFURX-AEFFLSMTSA-N	321200	US10179123, Example 2-21::US10179123, Example 2-21-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321200	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321200&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187956	384224298							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630093	COC(=O)c1cc2nc(Cc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OCC(F)(F)F	InChI=1S/C28H30F6N2O4/c1-16-9-18(14-26(2,3)13-16)36-22-12-23(39-15-27(29,30)31)20(25(37)38-4)11-21(22)35-24(36)10-17-5-7-19(8-6-17)40-28(32,33)34/h5-8,11-12,16,18H,9-10,13-15H2,1-4H3/t16-,18+/m1/s1	OPRNNFKOYJFURX-AEFFLSMTSA-N	321200	US10179123, Example 2-21::US10179123, Example 2-21-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321200	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321200&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187956	384224298							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630094	COC(=O)c1cc2nc(Cc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1OCC(F)(F)F	InChI=1S/C28H30F6N2O4/c1-16-9-18(14-26(2,3)13-16)36-22-12-23(39-15-27(29,30)31)20(25(37)38-4)11-21(22)35-24(36)10-17-5-7-19(8-6-17)40-28(32,33)34/h5-8,11-12,16,18H,9-10,13-15H2,1-4H3/t16-,18+/m0/s1	OPRNNFKOYJFURX-FUHWJXTLSA-N	321202	US10179123, Example 2-21-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 12000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321202	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321202&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187953	384224299							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630095	COC(=O)c1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Cc3ccc(OC(F)(F)F)cc3)nc2c1F	InChI=1S/C27H30F4N2O3/c1-25(2)13-17(14-26(3,4)15-25)33-20-11-10-19(24(34)35-5)22(28)23(20)32-21(33)12-16-6-8-18(9-7-16)36-27(29,30)31/h6-11,17H,12-15H2,1-5H3	KYJHIZVWZYXLIK-UHFFFAOYSA-N	321203	US10179123, Example 2-22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 800							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321203	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321203&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188352	384224300							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630096	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Cc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C#N	InChI=1S/C25H26F3N3O/c1-16-10-19(14-24(2,3)13-16)31-22-9-6-18(15-29)11-21(22)30-23(31)12-17-4-7-20(8-5-17)32-25(26,27)28/h4-9,11,16,19H,10,12-14H2,1-3H3/t16-,19+/m1/s1	NHXZOSXJQFIJRX-APWZRJJASA-N	321204	US10179123, Example 2-23	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321204	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321204&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188315	384224301							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630097	CC(C)Oc1ccc(Cc2nc3cc(ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)C#N)cc1	InChI=1S/C27H33N3O/c1-18(2)31-23-9-6-20(7-10-23)14-26-29-24-13-21(17-28)8-11-25(24)30(26)22-12-19(3)15-27(4,5)16-22/h6-11,13,18-19,22H,12,14-16H2,1-5H3/t19-,22+/m1/s1	AXVBFOKZKYODQH-KNQAVFIVSA-N	321205	US10179123, Example 2-24	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1500							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321205	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321205&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188317	384224302							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630098	CC(C)c1ccc(Cc2nc3cc(ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)C#N)cc1	InChI=1S/C27H33N3/c1-18(2)22-9-6-20(7-10-22)14-26-29-24-13-21(17-28)8-11-25(24)30(26)23-12-19(3)15-27(4,5)16-23/h6-11,13,18-19,23H,12,14-16H2,1-5H3/t19-,23+/m1/s1	PNAAMZCZKXTQHI-XXBNENTESA-N	321206	US10179123, Example 2-25	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 350							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321206	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321206&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188479	384224303							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630099	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Cc2ccc(cc2)C(F)(F)F)nc2cc(ccc12)C#N	InChI=1S/C25H26F3N3/c1-16-10-20(14-24(2,3)13-16)31-22-9-6-18(15-29)11-21(22)30-23(31)12-17-4-7-19(8-5-17)25(26,27)28/h4-9,11,16,20H,10,12-14H2,1-3H3/t16-,20+/m1/s1	BJCIQKSWMRKLML-UZLBHIALSA-N	321207	US10179123, Example 2-26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 700							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321207	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321207&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188195	384224304							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630100	COC(=O)CCc1cc2nc(Cc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1C	InChI=1S/C29H35F3N2O3/c1-18-12-22(17-28(3,4)16-18)34-25-13-19(2)21(8-11-27(35)36-5)15-24(25)33-26(34)14-20-6-9-23(10-7-20)37-29(30,31)32/h6-7,9-10,13,15,18,22H,8,11-12,14,16-17H2,1-5H3/t18-,22+/m1/s1	XHTZIFCBULPIHS-GCJKJVERSA-N	321208	US10179123, Example 2-27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 180							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321208	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321208&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188196	384224305							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630101	COC(=O)CCc1cc2nc(Cc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C29H35F3N2O4/c1-18-12-21(17-28(2,3)16-18)34-24-15-25(36-4)20(8-11-27(35)37-5)14-23(24)33-26(34)13-19-6-9-22(10-7-19)38-29(30,31)32/h6-7,9-10,14-15,18,21H,8,11-13,16-17H2,1-5H3/t18-,21+/m0/s1	FETAFQIBDCXIQG-GHTZIAJQSA-N	321209	US10179123, Example 2-28::US10179123, Example 2-28-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 180							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321209	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321209&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188208	384224306							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630102	COC(=O)CCc1cc2nc(Cc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C29H35F3N2O4/c1-18-12-21(17-28(2,3)16-18)34-24-15-25(36-4)20(8-11-27(35)37-5)14-23(24)33-26(34)13-19-6-9-22(10-7-19)38-29(30,31)32/h6-7,9-10,14-15,18,21H,8,11-13,16-17H2,1-5H3/t18-,21+/m1/s1	FETAFQIBDCXIQG-NQIIRXRSSA-N	321210	US10179123, Example 2-28-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1200							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321210	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321210&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188209	384224307							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630103	COC(=O)CCc1cc2nc(Cc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C29H35F3N2O4/c1-18-12-21(17-28(2,3)16-18)34-24-15-25(36-4)20(8-11-27(35)37-5)14-23(24)33-26(34)13-19-6-9-22(10-7-19)38-29(30,31)32/h6-7,9-10,14-15,18,21H,8,11-13,16-17H2,1-5H3/t18-,21+/m0/s1	FETAFQIBDCXIQG-GHTZIAJQSA-N	321209	US10179123, Example 2-28::US10179123, Example 2-28-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 100.0							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321209	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321209&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188208	384224306							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630104	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Cc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(O)=O	InChI=1S/C25H27F3N2O3/c1-15-10-18(14-24(2,3)13-15)30-21-9-6-17(23(31)32)12-20(21)29-22(30)11-16-4-7-19(8-5-16)33-25(26,27)28/h4-9,12,15,18H,10-11,13-14H2,1-3H3,(H,31,32)/t15-,18+/m1/s1	ZREQRRYKMSUNJY-QAPCUYQASA-N	321212	(+-) 2-[4-(trifluoromethoxy)benzyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylic Acid::US10179123, Example 2-29::US10179123, Example 2-29-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 100.0							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321212	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321212&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187980	384224308							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630105	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Cc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(O)=O	InChI=1S/C25H27F3N2O3/c1-15-10-18(14-24(2,3)13-15)30-21-9-6-17(23(31)32)12-20(21)29-22(30)11-16-4-7-19(8-5-16)33-25(26,27)28/h4-9,12,15,18H,10-11,13-14H2,1-3H3,(H,31,32)/t15-,18+/m1/s1	ZREQRRYKMSUNJY-QAPCUYQASA-N	321212	(+-) 2-[4-(trifluoromethoxy)benzyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylic Acid::US10179123, Example 2-29::US10179123, Example 2-29-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 140							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321212	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321212&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187980	384224308							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630106	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Cc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(O)=O	InChI=1S/C25H27F3N2O3/c1-15-10-18(14-24(2,3)13-15)30-21-9-6-17(23(31)32)12-20(21)29-22(30)11-16-4-7-19(8-5-16)33-25(26,27)28/h4-9,12,15,18H,10-11,13-14H2,1-3H3,(H,31,32)/t15-,18+/m0/s1	ZREQRRYKMSUNJY-MAUKXSAKSA-N	321214	2-[4-(trifluoromethoxy)benzyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylic Acid, Enantiomer B::US10179123, Example 2-29-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 50.0							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321214	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321214&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187981	384224309							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630107	CC(c1nc2cc(ccc2n1[C@@H]1C[C@H](C)CC(C)(C)C1)C(O)=O)c1ccc(OC(F)(F)F)cc1	InChI=1S/C26H29F3N2O3/c1-15-11-19(14-25(3,4)13-15)31-22-10-7-18(24(32)33)12-21(22)30-23(31)16(2)17-5-8-20(9-6-17)34-26(27,28)29/h5-10,12,15-16,19H,11,13-14H2,1-4H3,(H,32,33)/t15-,16?,19+/m0/s1	QQYQGUCMNAWWOW-SCVGIUIWSA-N	321215	US10179123, Example 2-30	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2700							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321215	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321215&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			135238578	384224310							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630108	C[C@@H](c1nc2cc(ccc2n1[C@@H]1C[C@H](C)CC(C)(C)C1)C(O)=O)c1ccc(OC(F)(F)F)cc1	InChI=1S/C26H29F3N2O3/c1-15-11-19(14-25(3,4)13-15)31-22-10-7-18(24(32)33)12-21(22)30-23(31)16(2)17-5-8-20(9-6-17)34-26(27,28)29/h5-10,12,15-16,19H,11,13-14H2,1-4H3,(H,32,33)/t15-,16+,19+/m0/s1	QQYQGUCMNAWWOW-FRQCXROJSA-N	321216	US10179123, Example 2-30-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321216	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321216&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			135238602	384224311							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630109	C[C@H](c1nc2cc(ccc2n1[C@@H]1C[C@H](C)CC(C)(C)C1)C(O)=O)c1ccc(OC(F)(F)F)cc1	InChI=1S/C26H29F3N2O3/c1-15-11-19(14-25(3,4)13-15)31-22-10-7-18(24(32)33)12-21(22)30-23(31)16(2)17-5-8-20(9-6-17)34-26(27,28)29/h5-10,12,15-16,19H,11,13-14H2,1-4H3,(H,32,33)/t15-,16-,19+/m0/s1	QQYQGUCMNAWWOW-TXPKVOOTSA-N	321217	US10179123, Example 2-30-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 950							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321217	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321217&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			135238577	384224312							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630110	C[C@@H](c1nc2cc(ccc2n1[C@H]1C[C@H](C)CC(C)(C)C1)C(O)=O)c1ccc(OC(F)(F)F)cc1	InChI=1S/C26H29F3N2O3/c1-15-11-19(14-25(3,4)13-15)31-22-10-7-18(24(32)33)12-21(22)30-23(31)16(2)17-5-8-20(9-6-17)34-26(27,28)29/h5-10,12,15-16,19H,11,13-14H2,1-4H3,(H,32,33)/t15-,16+,19-/m0/s1	QQYQGUCMNAWWOW-FCEWJHQRSA-N	321218	US10179123, Example 2-30-3	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321218	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321218&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138375181	384224313							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630111	C[C@H](c1nc2cc(ccc2n1[C@H]1C[C@H](C)CC(C)(C)C1)C(O)=O)c1ccc(OC(F)(F)F)cc1	InChI=1S/C26H29F3N2O3/c1-15-11-19(14-25(3,4)13-15)31-22-10-7-18(24(32)33)12-21(22)30-23(31)16(2)17-5-8-20(9-6-17)34-26(27,28)29/h5-10,12,15-16,19H,11,13-14H2,1-4H3,(H,32,33)/t15-,16-,19-/m0/s1	QQYQGUCMNAWWOW-BXWFABGCSA-N	321219	US10179123, Example 2-30-4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321219&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138375182	384224314							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630112	C[C@H]1C[C@H](CC(C)(C)C1)n1c(nc2cc(ccc12)C(O)=O)C(C)(C)c1ccc(OC(F)(F)F)cc1	InChI=1S/C27H31F3N2O3/c1-16-12-19(15-25(2,3)14-16)32-22-11-6-17(23(33)34)13-21(22)31-24(32)26(4,5)18-7-9-20(10-8-18)35-27(28,29)30/h6-11,13,16,19H,12,14-15H2,1-5H3,(H,33,34)/t16-,19+/m0/s1	WEOQGNPNVLKHNS-QFBILLFUSA-N	321220	US10179123, Example 2-31	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 3800							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321220&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188129	384224315							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630113	CC(C)Oc1ccc(Cc2nc3cc(ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)C(O)=O)cc1	InChI=1S/C27H34N2O3/c1-17(2)32-22-9-6-19(7-10-22)13-25-28-23-14-20(26(30)31)8-11-24(23)29(25)21-12-18(3)15-27(4,5)16-21/h6-11,14,17-18,21H,12-13,15-16H2,1-5H3,(H,30,31)/t18-,21+/m0/s1	LTNUCYVMQWKMOD-GHTZIAJQSA-N	321221	US10179123, Example 2-32::US10179123, Example 2-32-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 250							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321221&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188478	384224316							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630114	CC(C)Oc1ccc(Cc2nc3cc(ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)C(O)=O)cc1	InChI=1S/C27H34N2O3/c1-17(2)32-22-9-6-19(7-10-22)13-25-28-23-14-20(26(30)31)8-11-24(23)29(25)21-12-18(3)15-27(4,5)16-21/h6-11,14,17-18,21H,12-13,15-16H2,1-5H3,(H,30,31)/t18-,21+/m0/s1	LTNUCYVMQWKMOD-GHTZIAJQSA-N	321221	US10179123, Example 2-32::US10179123, Example 2-32-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 450							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321221&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188478	384224316							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630115	CC(C)Oc1ccc(Cc2nc3cc(ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)C(O)=O)cc1	InChI=1S/C27H34N2O3/c1-17(2)32-22-9-6-19(7-10-22)13-25-28-23-14-20(26(30)31)8-11-24(23)29(25)21-12-18(3)15-27(4,5)16-21/h6-11,14,17-18,21H,12-13,15-16H2,1-5H3,(H,30,31)/t18-,21+/m1/s1	LTNUCYVMQWKMOD-NQIIRXRSSA-N	321223	US10179123, Example 2-32-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 300							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321223&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124187975	384224317							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630116	CC(C)c1ccc(Cc2nc3cc(ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)C(O)=O)cc1	InChI=1S/C27H34N2O2/c1-17(2)20-8-6-19(7-9-20)13-25-28-23-14-21(26(30)31)10-11-24(23)29(25)22-12-18(3)15-27(4,5)16-22/h6-11,14,17-18,22H,12-13,15-16H2,1-5H3,(H,30,31)/t18-,22+/m0/s1	DOOIMSYYCLRNBV-PGRDOPGGSA-N	321224	US10179123, Example 2-33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 50.0							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321224	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321224&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188167	384224318							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630117	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Cc2ccc(cc2)C(F)(F)F)nc2cc(ccc12)C(O)=O	InChI=1S/C25H27F3N2O2/c1-15-10-19(14-24(2,3)13-15)30-21-9-6-17(23(31)32)12-20(21)29-22(30)11-16-4-7-18(8-5-16)25(26,27)28/h4-9,12,15,19H,10-11,13-14H2,1-3H3,(H,31,32)/t15-,19+/m0/s1	AGAYBNVHXRAKQO-HNAYVOBHSA-N	321225	US10179123, Example 2-34	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 120							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321225	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321225&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188166	384224319							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630118	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Cc2ccc(F)cc2)nc2cc(ccc12)C(O)=O	InChI=1S/C24H27FN2O2/c1-15-10-19(14-24(2,3)13-15)27-21-9-6-17(23(28)29)12-20(21)26-22(27)11-16-4-7-18(25)8-5-16/h4-9,12,15,19H,10-11,13-14H2,1-3H3,(H,28,29)/t15-,19+/m0/s1	FMJOQKBCYRNMJV-HNAYVOBHSA-N	321226	US10179123, Example 2-35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1300							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321226&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188104	384224320							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630119	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Cc2ccc(C)cc2)nc2cc(ccc12)C(O)=O	InChI=1S/C25H30N2O2/c1-16-5-7-18(8-6-16)12-23-26-21-13-19(24(28)29)9-10-22(21)27(23)20-11-17(2)14-25(3,4)15-20/h5-10,13,17,20H,11-12,14-15H2,1-4H3,(H,28,29)/t17-,20+/m0/s1	AZECSPLSWPGXJV-FXAWDEMLSA-N	321227	US10179123, Example 2-36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 580							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321227&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			135238589	384224321							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630120	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Cc2ccc(cc2)C(C)(C)C)nc2cc(ccc12)C(O)=O	InChI=1S/C28H36N2O2/c1-18-13-22(17-28(5,6)16-18)30-24-12-9-20(26(31)32)15-23(24)29-25(30)14-19-7-10-21(11-8-19)27(2,3)4/h7-12,15,18,22H,13-14,16-17H2,1-6H3,(H,31,32)/t18-,22+/m0/s1	HWRKDZZHVKWXAS-PGRDOPGGSA-N	321228	US10179123, Example 2-37	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 50.0							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321228&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			135238595	384224322							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630121	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Cc2ccccc2)nc2cc(ccc12)C(O)=O	InChI=1S/C24H28N2O2/c1-16-11-19(15-24(2,3)14-16)26-21-10-9-18(23(27)28)13-20(21)25-22(26)12-17-7-5-4-6-8-17/h4-10,13,16,19H,11-12,14-15H2,1-3H3,(H,27,28)/t16-,19+/m0/s1	ZKZSGEYYAUVULC-QFBILLFUSA-N	321229	US10179123, Example 2-38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2400							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321229&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188207	384224323							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630122	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Cc2ccccc2OC(F)(F)F)nc2cc(ccc12)C(O)=O	InChI=1S/C25H27F3N2O3/c1-15-10-18(14-24(2,3)13-15)30-20-9-8-17(23(31)32)11-19(20)29-22(30)12-16-6-4-5-7-21(16)33-25(26,27)28/h4-9,11,15,18H,10,12-14H2,1-3H3,(H,31,32)/t15-,18+/m0/s1	QADFBBDIORPRMC-MAUKXSAKSA-N	321230	US10179123, Example 2-39	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321230&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			135238618	384224324							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630123	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Cc2cccc(OC(F)(F)F)c2)nc2cc(ccc12)C(O)=O	InChI=1S/C25H27F3N2O3/c1-15-9-18(14-24(2,3)13-15)30-21-8-7-17(23(31)32)12-20(21)29-22(30)11-16-5-4-6-19(10-16)33-25(26,27)28/h4-8,10,12,15,18H,9,11,13-14H2,1-3H3,(H,31,32)/t15-,18+/m0/s1	OOCOXGXJNWCOSA-MAUKXSAKSA-N	321231	US10179123, Example 2-40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1800							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321231&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			135238584	384224325							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630124	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Cc2sc(nc2C)-c2ccccc2)nc2cc(ccc12)C(O)=O	InChI=1S/C28H31N3O2S/c1-17-12-21(16-28(3,4)15-17)31-23-11-10-20(27(32)33)13-22(23)30-25(31)14-24-18(2)29-26(34-24)19-8-6-5-7-9-19/h5-11,13,17,21H,12,14-16H2,1-4H3,(H,32,33)/t17-,21+/m0/s1	UUZRGVMTGBEUJS-LAUBAEHRSA-N	321232	US10179123, Example 2-41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2300							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321232	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321232&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188370	384224326							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630125	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Cc2c(C)[nH]c3ccc(F)cc23)nc2cc(ccc12)C(O)=O |r|	InChI=1S/C27H30FN3O2/c1-15-9-19(14-27(3,4)13-15)31-24-8-5-17(26(32)33)10-23(24)30-25(31)12-20-16(2)29-22-7-6-18(28)11-21(20)22/h5-8,10-11,15,19,29H,9,12-14H2,1-4H3,(H,32,33)	YDWLVGRYKBMSSC-UHFFFAOYSA-N	321233	US10179123, Example 2-42	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 7000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321233	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321233&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188367	384224327							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630126	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Cc2cn(C)c3ccccc23)nc2cc(ccc12)C(O)=O	InChI=1S/C27H31N3O2/c1-17-11-20(15-27(2,3)14-17)30-24-10-9-18(26(31)32)12-22(24)28-25(30)13-19-16-29(4)23-8-6-5-7-21(19)23/h5-10,12,16-17,20H,11,13-15H2,1-4H3,(H,31,32)/t17-,20+/m0/s1	SMVHOAGHHOKLJT-FXAWDEMLSA-N	321234	US10179123, Example 2-43	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 6600							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321234&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188474	384224328							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630127	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Cc2ccc(OC(F)(F)F)cc2)nc2cc(C(O)=O)c(C)cc12	InChI=1S/C26H29F3N2O3/c1-15-9-18(14-25(3,4)13-15)31-22-10-16(2)20(24(32)33)12-21(22)30-23(31)11-17-5-7-19(8-6-17)34-26(27,28)29/h5-8,10,12,15,18H,9,11,13-14H2,1-4H3,(H,32,33)/t15-,18+/m0/s1	CCTMIENZLLMTEM-MAUKXSAKSA-N	321235	US10179123, Example 2-44::US10179123, Example 2-44-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 70.0							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321235&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188359	384224329							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630128	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Cc2ccc(OC(F)(F)F)cc2)nc2cc(C(O)=O)c(C)cc12	InChI=1S/C26H29F3N2O3/c1-15-9-18(14-25(3,4)13-15)31-22-10-16(2)20(24(32)33)12-21(22)30-23(31)11-17-5-7-19(8-6-17)34-26(27,28)29/h5-8,10,12,15,18H,9,11,13-14H2,1-4H3,(H,32,33)/t15-,18+/m0/s1	CCTMIENZLLMTEM-MAUKXSAKSA-N	321235	US10179123, Example 2-44::US10179123, Example 2-44-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20.0							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321235&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188359	384224329							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630129	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Cc2ccc(OC(F)(F)F)cc2)nc2cc(C(O)=O)c(C)cc12	InChI=1S/C26H29F3N2O3/c1-15-9-18(14-25(3,4)13-15)31-22-10-16(2)20(24(32)33)12-21(22)30-23(31)11-17-5-7-19(8-6-17)34-26(27,28)29/h5-8,10,12,15,18H,9,11,13-14H2,1-4H3,(H,32,33)/t15-,18+/m1/s1	CCTMIENZLLMTEM-QAPCUYQASA-N	321237	US10179123, Example 2-44-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 130							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321237&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188358	384224330							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630130	COc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Cc3ccc(OC(F)(F)F)cc3)nc2cc1C(O)=O	InChI=1S/C26H29F3N2O4/c1-15-9-17(14-25(2,3)13-15)31-21-12-22(34-4)19(24(32)33)11-20(21)30-23(31)10-16-5-7-18(8-6-16)35-26(27,28)29/h5-8,11-12,15,17H,9-10,13-14H2,1-4H3,(H,32,33)/t15-,17+/m0/s1	VHUGUUUOMDSMDQ-DOTOQJQBSA-N	321238	US10179123, Example 2-45::US10179123, Example 2-45-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 30.0							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321238	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321238&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188369	384224331							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630131	COc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Cc3ccc(OC(F)(F)F)cc3)nc2cc1C(O)=O	InChI=1S/C26H29F3N2O4/c1-15-9-17(14-25(2,3)13-15)31-21-12-22(34-4)19(24(32)33)11-20(21)30-23(31)10-16-5-7-18(8-6-16)35-26(27,28)29/h5-8,11-12,15,17H,9-10,13-14H2,1-4H3,(H,32,33)/t15-,17+/m0/s1	VHUGUUUOMDSMDQ-DOTOQJQBSA-N	321238	US10179123, Example 2-45::US10179123, Example 2-45-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 300							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321238	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321238&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188369	384224331							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630132	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Cc3ccc(OC(F)(F)F)cc3)nc2cc1C(O)=O	InChI=1S/C26H29F3N2O4/c1-15-9-17(14-25(2,3)13-15)31-21-12-22(34-4)19(24(32)33)11-20(21)30-23(31)10-16-5-7-18(8-6-16)35-26(27,28)29/h5-8,11-12,15,17H,9-10,13-14H2,1-4H3,(H,32,33)/t15-,17+/m1/s1	VHUGUUUOMDSMDQ-WBVHZDCISA-N	321240	US10179123, Example 2-45-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20.0							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321240&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188366	384224332							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630133	CC(C)Oc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Cc3ccc(OC(F)(F)F)cc3)nc2cc1C(O)=O	InChI=1S/C28H33F3N2O4/c1-16(2)36-24-13-23-22(12-21(24)26(34)35)32-25(33(23)19-10-17(3)14-27(4,5)15-19)11-18-6-8-20(9-7-18)37-28(29,30)31/h6-9,12-13,16-17,19H,10-11,14-15H2,1-5H3,(H,34,35)/t17-,19+/m0/s1	DWQOHKUSAAZFOQ-PKOBYXMFSA-N	321241	US10179123, Example 2-46::US10179123, Example 2-46-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 330							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321241&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188375	384224333							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630134	CC(C)Oc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Cc3ccc(OC(F)(F)F)cc3)nc2cc1C(O)=O	InChI=1S/C28H33F3N2O4/c1-16(2)36-24-13-23-22(12-21(24)26(34)35)32-25(33(23)19-10-17(3)14-27(4,5)15-19)11-18-6-8-20(9-7-18)37-28(29,30)31/h6-9,12-13,16-17,19H,10-11,14-15H2,1-5H3,(H,34,35)/t17-,19+/m0/s1	DWQOHKUSAAZFOQ-PKOBYXMFSA-N	321241	US10179123, Example 2-46::US10179123, Example 2-46-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 120							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321241&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188375	384224333							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630135	CC(C)Oc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Cc3ccc(OC(F)(F)F)cc3)nc2cc1C(O)=O	InChI=1S/C28H33F3N2O4/c1-16(2)36-24-13-23-22(12-21(24)26(34)35)32-25(33(23)19-10-17(3)14-27(4,5)15-19)11-18-6-8-20(9-7-18)37-28(29,30)31/h6-9,12-13,16-17,19H,10-11,14-15H2,1-5H3,(H,34,35)/t17-,19+/m1/s1	DWQOHKUSAAZFOQ-MJGOQNOKSA-N	321243	US10179123, Example 2-46-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 500							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321243	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321243&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188374	384224334							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630136	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Cc2ccc(OC(F)(F)F)cc2)nc2cc(C(O)=O)c(OCC(F)(F)F)cc12	InChI=1S/C27H28F6N2O4/c1-15-8-17(13-25(2,3)12-15)35-21-11-22(38-14-26(28,29)30)19(24(36)37)10-20(21)34-23(35)9-16-4-6-18(7-5-16)39-27(31,32)33/h4-7,10-11,15,17H,8-9,12-14H2,1-3H3,(H,36,37)/t15-,17+/m0/s1	ZQZXHOBOJDHECS-DOTOQJQBSA-N	321244	US10179123, Example 2-47::US10179123, Example 2-47-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 1000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321244&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188365	384224335							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630137	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Cc2ccc(OC(F)(F)F)cc2)nc2cc(C(O)=O)c(OCC(F)(F)F)cc12	InChI=1S/C27H28F6N2O4/c1-15-8-17(13-25(2,3)12-15)35-21-11-22(38-14-26(28,29)30)19(24(36)37)10-20(21)34-23(35)9-16-4-6-18(7-5-16)39-27(31,32)33/h4-7,10-11,15,17H,8-9,12-14H2,1-3H3,(H,36,37)/t15-,17+/m0/s1	ZQZXHOBOJDHECS-DOTOQJQBSA-N	321244	US10179123, Example 2-47::US10179123, Example 2-47-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 2000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321244&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188365	384224335							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630138	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Cc2ccc(OC(F)(F)F)cc2)nc2cc(C(O)=O)c(OCC(F)(F)F)cc12	InChI=1S/C27H28F6N2O4/c1-15-8-17(13-25(2,3)12-15)35-21-11-22(38-14-26(28,29)30)19(24(36)37)10-20(21)34-23(35)9-16-4-6-18(7-5-16)39-27(31,32)33/h4-7,10-11,15,17H,8-9,12-14H2,1-3H3,(H,36,37)/t15-,17+/m1/s1	ZQZXHOBOJDHECS-WBVHZDCISA-N	321246	US10179123, Example 2-47-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 650							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321246	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321246&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188364	384224336							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630139	CC1(C)CC(CC(C)(C)C1)n1c(Cc2ccc(OC(F)(F)F)cc2)nc2c(F)c(ccc12)C(O)=O	InChI=1S/C26H28F4N2O3/c1-24(2)12-16(13-25(3,4)14-24)32-19-10-9-18(23(33)34)21(27)22(19)31-20(32)11-15-5-7-17(8-6-15)35-26(28,29)30/h5-10,16H,11-14H2,1-4H3,(H,33,34)	HUDCUJCUVVVHPU-UHFFFAOYSA-N	321247	US10179123, Example 2-48	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 80.0							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321247	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321247&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188308	384224337							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630140	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Cc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(O)=O)c(C)cc12	InChI=1S/C28H33F3N2O3/c1-17-11-21(16-27(3,4)15-17)33-24-12-18(2)20(7-10-26(34)35)14-23(24)32-25(33)13-19-5-8-22(9-6-19)36-28(29,30)31/h5-6,8-9,12,14,17,21H,7,10-11,13,15-16H2,1-4H3,(H,34,35)/t17-,21+/m0/s1	AWPVWNGFTKELEN-LAUBAEHRSA-N	321248	US10179123, Example 2-49	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 80.0							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321248	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321248&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188304	384224338							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630141	COc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Cc3ccc(OC(F)(F)F)cc3)nc2cc1CCC(O)=O	InChI=1S/C28H33F3N2O4/c1-17-11-20(16-27(2,3)15-17)33-23-14-24(36-4)19(7-10-26(34)35)13-22(23)32-25(33)12-18-5-8-21(9-6-18)37-28(29,30)31/h5-6,8-9,13-14,17,20H,7,10-12,15-16H2,1-4H3,(H,34,35)/t17-,20+/m0/s1	NMTADFRUSNUKBF-FXAWDEMLSA-N	321249	US10179123, Example 2-50::US10179123, Example 2-50-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 30.0							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321249	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321249&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188328	384224339							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630142	COc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Cc3ccc(OC(F)(F)F)cc3)nc2cc1CCC(O)=O	InChI=1S/C28H33F3N2O4/c1-17-11-20(16-27(2,3)15-17)33-23-14-24(36-4)19(7-10-26(34)35)13-22(23)32-25(33)12-18-5-8-21(9-6-18)37-28(29,30)31/h5-6,8-9,13-14,17,20H,7,10-12,15-16H2,1-4H3,(H,34,35)/t17-,20+/m0/s1	NMTADFRUSNUKBF-FXAWDEMLSA-N	321249	US10179123, Example 2-50::US10179123, Example 2-50-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 200							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321249	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321249&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188328	384224339							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630143	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Cc3ccc(OC(F)(F)F)cc3)nc2cc1CCC(O)=O	InChI=1S/C28H33F3N2O4/c1-17-11-20(16-27(2,3)15-17)33-23-14-24(36-4)19(7-10-26(34)35)13-22(23)32-25(33)12-18-5-8-21(9-6-18)37-28(29,30)31/h5-6,8-9,13-14,17,20H,7,10-12,15-16H2,1-4H3,(H,34,35)/t17-,20+/m1/s1	NMTADFRUSNUKBF-XLIONFOSSA-N	321251	US10179123, Example 2-50-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 20.0							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321251	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321251&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188323	384224340							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630144	CC1(C)CC(CC(C)(C)C1)n1c(Cc2ccc(OC(F)(F)F)cc2)nc2c(F)c(CCC(O)=O)ccc12	InChI=1S/C28H32F4N2O3/c1-26(2)14-19(15-27(3,4)16-26)34-21-11-7-18(8-12-23(35)36)24(29)25(21)33-22(34)13-17-5-9-20(10-6-17)37-28(30,31)32/h5-7,9-11,19H,8,12-16H2,1-4H3,(H,35,36)	MUFOBFFYPSNCDE-UHFFFAOYSA-N	321252	3-{4-fluoro-1-(3,3,5,5-tetramethylcyclohexyl)-2-[4-(trifluoromethoxy)benzyl]-1H-benzimidazol-5-yl}Propanoic Acid::US10179123, Example 2-52	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 80.0							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321252	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321252&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188379	384224341							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630145	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(nc2c1)C(C)c1ccc(OC(F)(F)F)cc1	InChI=1S/C27H31F3N2O3/c1-16-12-20(15-26(3,4)14-16)32-23-11-8-19(25(33)34-5)13-22(23)31-24(32)17(2)18-6-9-21(10-7-18)35-27(28,29)30/h6-11,13,16-17,20H,12,14-15H2,1-5H3/t16-,17?,20+/m1/s1	RAIJWIZTJZLJES-ZYLKAMJESA-N	321253	US10179123, Reference compound 2-4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321253	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321253&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			135238737	384224342							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630146	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(nc2c1)[C@H](C)c1ccc(OC(F)(F)F)cc1	InChI=1S/C27H31F3N2O3/c1-16-12-20(15-26(3,4)14-16)32-23-11-8-19(25(33)34-5)13-22(23)31-24(32)17(2)18-6-9-21(10-7-18)35-27(28,29)30/h6-11,13,16-17,20H,12,14-15H2,1-5H3/t16-,17-,20+/m1/s1	RAIJWIZTJZLJES-HLIPFELVSA-N	321254	US10179123, Reference compound 2-4-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321254	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321254&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138375183	384224343							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630147	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(nc2c1)[C@@H](C)c1ccc(OC(F)(F)F)cc1	InChI=1S/C27H31F3N2O3/c1-16-12-20(15-26(3,4)14-16)32-23-11-8-19(25(33)34-5)13-22(23)31-24(32)17(2)18-6-9-21(10-7-18)35-27(28,29)30/h6-11,13,16-17,20H,12,14-15H2,1-5H3/t16-,17+,20+/m1/s1	RAIJWIZTJZLJES-UWVAXJGDSA-N	321255	US10179123, Reference compound 2-4-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321255	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321255&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138375184	384224344							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630148	COC(=O)c1ccc2n([C@@H]3C[C@@H](C)CC(C)(C)C3)c(nc2c1)[C@H](C)c1ccc(OC(F)(F)F)cc1	InChI=1S/C27H31F3N2O3/c1-16-12-20(15-26(3,4)14-16)32-23-11-8-19(25(33)34-5)13-22(23)31-24(32)17(2)18-6-9-21(10-7-18)35-27(28,29)30/h6-11,13,16-17,20H,12,14-15H2,1-5H3/t16-,17-,20-/m1/s1	RAIJWIZTJZLJES-MBOZVWFJSA-N	321256	US10179123, Reference compound 2-4-3	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321256	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321256&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138375185	384224345							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630149	COC(=O)c1ccc2n([C@@H]3C[C@@H](C)CC(C)(C)C3)c(nc2c1)[C@@H](C)c1ccc(OC(F)(F)F)cc1	InChI=1S/C27H31F3N2O3/c1-16-12-20(15-26(3,4)14-16)32-23-11-8-19(25(33)34-5)13-22(23)31-24(32)17(2)18-6-9-21(10-7-18)35-27(28,29)30/h6-11,13,16-17,20H,12,14-15H2,1-5H3/t16-,17+,20-/m1/s1	RAIJWIZTJZLJES-FUHIMQAGSA-N	321257	US10179123, Reference compound 2-4-4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321257	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321257&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138375186	384224346							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
630150	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(nc2c1)C(C)(C)c1ccc(OC(F)(F)F)cc1	InChI=1S/C28H33F3N2O3/c1-17-13-20(16-26(2,3)15-17)33-23-12-7-18(24(34)35-6)14-22(23)32-25(33)27(4,5)19-8-10-21(11-9-19)36-28(29,30)31/h7-12,14,17,20H,13,15-16H2,1-6H3/t17-,20+/m1/s1	XGZVTRBPOIJQGL-XLIONFOSSA-N	321258	US10179123, Reference compound 2-5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		>10000							US Patent		10.7270/Q2SJ1NQX		aid1796670	US10179123	Panknin, O; Zimmermann, K; Neuhaus, R	1/15/2019	5/16/2019	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=321258	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=321258&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124188244	384224347							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642292	CC(C)c1nc(N2CCN(CC2)S(=O)(=O)c2cccs2)c(C#N)c2CCOCc12	InChI=1S/C20H24N4O3S2/c1-14(2)19-17-13-27-10-5-15(17)16(12-21)20(22-19)23-6-8-24(9-7-23)29(25,26)18-4-3-11-28-18/h3-4,11,14H,5-10,13H2,1-2H3	GKLHXNZNBWINKV-UHFFFAOYSA-N	326404	US9662327, Compound 101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326404	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326404&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295055	384581358							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642293	CC(C)c1nc(N2CCN(CC2)C(=O)Nc2ccc(F)cc2)c(C#N)c2CCOCc12	InChI=1S/C23H26FN5O2/c1-15(2)21-20-14-31-12-7-18(20)19(13-25)22(27-21)28-8-10-29(11-9-28)23(30)26-17-5-3-16(24)4-6-17/h3-6,15H,7-12,14H2,1-2H3,(H,26,30)	QZKQORCOXMSPCX-UHFFFAOYSA-N	326405	US9662327, Compound 102	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326405	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326405&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119328	384581359							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642294	COc1ccc(OC(=O)N2CCN(CC2)c2nc(C(C)C)c3COCCc3c2C#N)cc1	InChI=1S/C24H28N4O4/c1-16(2)22-21-15-31-13-8-19(21)20(14-25)23(26-22)27-9-11-28(12-10-27)24(29)32-18-6-4-17(30-3)5-7-18/h4-7,16H,8-13,15H2,1-3H3	IMWBYPWKXGTENZ-UHFFFAOYSA-N	326406	US9662327, Compound 103	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326406	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326406&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71476967	384581360							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642295	CC(C)c1nc(N2CCN(CC2)C(=O)c2c[nH]c3ccccc23)c(C#N)c2CCOCc12	InChI=1S/C25H27N5O2/c1-16(2)23-21-15-32-12-7-17(21)19(13-26)24(28-23)29-8-10-30(11-9-29)25(31)20-14-27-22-6-4-3-5-18(20)22/h3-6,14,16,27H,7-12,15H2,1-2H3	RDHZXBJNNIRLFY-UHFFFAOYSA-N	326407	US9662327, Compound 104	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326407	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326407&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282854	384581361							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642296	CC(C)c1nc(N2CCN(CC2)C(=O)c2ccc(Cl)c(Cl)c2)c(C#N)c2CCOCc12	InChI=1S/C23H24Cl2N4O2/c1-14(2)21-18-13-31-10-5-16(18)17(12-26)22(27-21)28-6-8-29(9-7-28)23(30)15-3-4-19(24)20(25)11-15/h3-4,11,14H,5-10,13H2,1-2H3	AASVBIOTMYAQFY-UHFFFAOYSA-N	326408	US9662327, Compound 105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326408	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326408&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283287	384581362							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642297	CC(C)c1nc(N2CCN(CC2)C(=O)c2ccc(Cl)cc2Cl)c(C#N)c2CCOCc12	InChI=1S/C23H24Cl2N4O2/c1-14(2)21-19-13-31-10-5-16(19)18(12-26)22(27-21)28-6-8-29(9-7-28)23(30)17-4-3-15(24)11-20(17)25/h3-4,11,14H,5-10,13H2,1-2H3	BWEQEKYYHFNYHS-UHFFFAOYSA-N	326409	US9662327, Compound 106	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326409	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326409&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283068	384581363							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642298	CC(C)c1nc(N2CCN(CC2)C(=O)NC2CCCCC2)c(C#N)c2CCOCc12	InChI=1S/C23H33N5O2/c1-16(2)21-20-15-30-13-8-18(20)19(14-24)22(26-21)27-9-11-28(12-10-27)23(29)25-17-6-4-3-5-7-17/h16-17H,3-13,15H2,1-2H3,(H,25,29)	MPBQYLDMGCNGQX-UHFFFAOYSA-N	326410	US9662327, Compound 107	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326410	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326410&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283107	384581364							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642299	CC(C)c1nc(N2CC(C)N(C(C)C2)C(=O)NC2CCCCC2)c(C#N)c2CCOCc12	InChI=1S/C25H37N5O2/c1-16(2)23-22-15-32-11-10-20(22)21(12-26)24(28-23)29-13-17(3)30(18(4)14-29)25(31)27-19-8-6-5-7-9-19/h16-19H,5-11,13-15H2,1-4H3,(H,27,31)	KKJQFYYTIBRTRR-UHFFFAOYSA-N	326411	US9662327, Compound 108	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326411	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326411&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119442	384581365							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642300	CC(C)c1nc(N2C[C@H](C)N([C@H](C)C2)C(=O)NC2CCCCC2)c(C#N)c2CCCCc12	InChI=1S/C26H39N5O/c1-17(2)24-22-13-9-8-12-21(22)23(14-27)25(29-24)30-15-18(3)31(19(4)16-30)26(32)28-20-10-6-5-7-11-20/h17-20H,5-13,15-16H2,1-4H3,(H,28,32)/t18-,19+	HASJZFMTLOAIMF-KDURUIRLSA-N	326412	US9662327, Compound 109	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326412	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326412&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282888	384581366							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642301	O=C(N1CCN(CC1)c1nc(C2CCCCC2)c2COCCc2c1C#N)c1ccco1	InChI=1S/C24H28N4O3/c25-15-19-18-8-14-30-16-20(18)22(17-5-2-1-3-6-17)26-23(19)27-9-11-28(12-10-27)24(29)21-7-4-13-31-21/h4,7,13,17H,1-3,5-6,8-12,14,16H2	RSHNSLWYTWOGDU-UHFFFAOYSA-N	326413	US9662327, Compound 110	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326413	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326413&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283361	384581367							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642302	CC(C)c1nc(N2CCN(CC2c2ccccc2)C(=O)c2ccco2)c(C#N)c2CCOCc12	InChI=1S/C27H28N4O3/c1-18(2)25-22-17-33-14-10-20(22)21(15-28)26(29-25)31-12-11-30(27(32)24-9-6-13-34-24)16-23(31)19-7-4-3-5-8-19/h3-9,13,18,23H,10-12,14,16-17H2,1-2H3	MQGILUTVEUSGBA-UHFFFAOYSA-N	326414	US9662327, Compound 111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326414	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326414&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282749	384581368							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642303	CC1CN(CC(C)N1C(=O)c1ccco1)c1nc(-c2ccc(C)cc2)c2COCCc2c1C#N	InChI=1S/C27H28N4O3/c1-17-6-8-20(9-7-17)25-23-16-33-12-10-21(23)22(13-28)26(29-25)30-14-18(2)31(19(3)15-30)27(32)24-5-4-11-34-24/h4-9,11,18-19H,10,12,14-16H2,1-3H3	QQZMGZURBFKHBJ-UHFFFAOYSA-N	326415	US9662327, Compound 112	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326415	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326415&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295059	384581369							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642304	CC(C)c1nc(N2CCN(CC2)C(=O)c2ccoc2C)c(C#N)c2CCOCc12	InChI=1S/C22H26N4O3/c1-14(2)20-19-13-28-10-4-17(19)18(12-23)21(24-20)25-6-8-26(9-7-25)22(27)16-5-11-29-15(16)3/h5,11,14H,4,6-10,13H2,1-3H3	UHLDSTLYHKKDIF-UHFFFAOYSA-N	326416	US9662327, Compound 113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326416	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326416&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119623	384581370							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642305	CC(CN(C(C)C)c1nc(C(C)C)c2COCCc2c1C#N)NC(=O)c1ccco1	InChI=1S/C23H30N4O3/c1-14(2)21-19-13-29-10-8-17(19)18(11-24)22(26-21)27(15(3)4)12-16(5)25-23(28)20-7-6-9-30-20/h6-7,9,14-16H,8,10,12-13H2,1-5H3,(H,25,28)	KMNPDDOMGZOQBS-UHFFFAOYSA-N	326417	US9662327, Compound 114	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326417	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326417&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295057	384581371							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642306	CC(C)c1nc(N2CCN(CC2)C(=O)NC2CCCCC2)c(C#N)c2CCCCc12	InChI=1S/C24H35N5O/c1-17(2)22-20-11-7-6-10-19(20)21(16-25)23(27-22)28-12-14-29(15-13-28)24(30)26-18-8-4-3-5-9-18/h17-18H,3-15H2,1-2H3,(H,26,30)	FUDFHXNFAMVRMB-UHFFFAOYSA-N	326418	US9662327, Compound 115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326418	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326418&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119450	384581372							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642307	CC(C)c1nc(N2CCN(CC2)C(=O)c2ccco2)c(C#N)c2CCC(C)(C)Cc12	InChI=1S/C24H30N4O2/c1-16(2)21-18-14-24(3,4)8-7-17(18)19(15-25)22(26-21)27-9-11-28(12-10-27)23(29)20-6-5-13-30-20/h5-6,13,16H,7-12,14H2,1-4H3	JBEGNTSOZOEEIH-UHFFFAOYSA-N	326419	US9662327, Compound 116	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326419	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326419&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118653	384581373							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642308	CC1(C)Cc2c(CO1)c(nc(N1CCN(CC1)C(=O)c1ccco1)c2C#N)C1CCCCC1	InChI=1S/C26H32N4O3/c1-26(2)15-19-20(16-27)24(28-23(21(19)17-33-26)18-7-4-3-5-8-18)29-10-12-30(13-11-29)25(31)22-9-6-14-32-22/h6,9,14,18H,3-5,7-8,10-13,15,17H2,1-2H3	QBQVOHKKAZQTGK-UHFFFAOYSA-N	326420	US9662327, Compound 117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326420	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326420&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282902	384581374							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642309	O=C(N1CCN(CC1)c1nc(C2CCCCC2)c2COCCc2c1C#N)c1c[nH]c2ccccc12	InChI=1S/C28H31N5O2/c29-16-22-20-10-15-35-18-24(20)26(19-6-2-1-3-7-19)31-27(22)32-11-13-33(14-12-32)28(34)23-17-30-25-9-5-4-8-21(23)25/h4-5,8-9,17,19,30H,1-3,6-7,10-15,18H2	HJKCKYCHVOFVMR-UHFFFAOYSA-N	326421	US9662327, Compound 118	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326421	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326421&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119437	384581375							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642310	O=C(N1CCN(CC1)c1nc(C2CCCCC2)c2COCCc2c1C#N)c1cccc2[nH]ccc12	InChI=1S/C28H31N5O2/c29-17-23-20-10-16-35-18-24(20)26(19-5-2-1-3-6-19)31-27(23)32-12-14-33(15-13-32)28(34)22-7-4-8-25-21(22)9-11-30-25/h4,7-9,11,19,30H,1-3,5-6,10,12-16,18H2	LZGDXVJVNZCGET-UHFFFAOYSA-N	326422	US9662327, Compound 119	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326422	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326422&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119217	384581376							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642311	O=C(N1CCN(CC1)c1nc(C2CCCCC2)c2COCCc2c1C#N)c1ccoc1	InChI=1S/C24H28N4O3/c25-14-20-19-7-13-31-16-21(19)22(17-4-2-1-3-5-17)26-23(20)27-8-10-28(11-9-27)24(29)18-6-12-30-15-18/h6,12,15,17H,1-5,7-11,13,16H2	VGQLSJYRCKMERB-UHFFFAOYSA-N	326423	US9662327, Compound 120	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326423	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326423&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283255	384581377							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642312	Cc1cc(C(=O)N2CCN(CC2)c2nc(C3CCCCC3)c3COCCc3c2C#N)c(C)o1	InChI=1S/C26H32N4O3/c1-17-14-21(18(2)33-17)26(31)30-11-9-29(10-12-30)25-22(15-27)20-8-13-32-16-23(20)24(28-25)19-6-4-3-5-7-19/h14,19H,3-13,16H2,1-2H3	IQTOHJWSHYCIOB-UHFFFAOYSA-N	326424	US9662327, Compound 121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326424	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326424&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283019	384581378							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642313	O=C(N1CCN(CC1)c1nc(C2CCCCC2)c2COCCc2c1C#N)c1ccc2[nH]ccc2c1	InChI=1S/C28H31N5O2/c29-17-23-22-9-15-35-18-24(22)26(19-4-2-1-3-5-19)31-27(23)32-11-13-33(14-12-32)28(34)21-6-7-25-20(16-21)8-10-30-25/h6-8,10,16,19,30H,1-5,9,11-15,18H2	GVOMMJYQTXYJNT-UHFFFAOYSA-N	326425	US9662327, Compound 122	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326425	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326425&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119427	384581379							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642314	O=C(N1CCN(CC1)c1nc(C2CCCCC2)c2COCCc2c1C#N)c1ccc2cc[nH]c2c1	InChI=1S/C28H31N5O2/c29-17-23-22-9-15-35-18-24(22)26(20-4-2-1-3-5-20)31-27(23)32-11-13-33(14-12-32)28(34)21-7-6-19-8-10-30-25(19)16-21/h6-8,10,16,20,30H,1-5,9,11-15,18H2	USWOYHSTBXEPDC-UHFFFAOYSA-N	326426	US9662327, Compound 123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326426	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326426&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119189	384581380							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642315	O=C(N1CCN(CC1)c1nc(C2CCCC2)c2COCCc2c1C#N)c1ccco1	InChI=1S/C23H26N4O3/c24-14-18-17-7-13-29-15-19(17)21(16-4-1-2-5-16)25-22(18)26-8-10-27(11-9-26)23(28)20-6-3-12-30-20/h3,6,12,16H,1-2,4-5,7-11,13,15H2	XPQDKFMNFUQHPM-UHFFFAOYSA-N	326427	US9662327, Compound 124	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326427	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326427&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283157	384581381							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642316	CC(C)c1nc(N2CCN(C(C)C2)C(=O)c2ccco2)c(C#N)c2CCCCc12	InChI=1S/C23H28N4O2/c1-15(2)21-18-8-5-4-7-17(18)19(13-24)22(25-21)26-10-11-27(16(3)14-26)23(28)20-9-6-12-29-20/h6,9,12,15-16H,4-5,7-8,10-11,14H2,1-3H3	BRNLCBVGJRVMLS-UHFFFAOYSA-N	326428	US9662327, Compound 125	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326428	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326428&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282843	384581382							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642317	C[C@H]1CN(C[C@@H](C)N1C(=O)c1ccco1)c1nc(C2CCCC2)c2COCCc2c1C#N	InChI=1S/C25H30N4O3/c1-16-13-28(14-17(2)29(16)25(30)22-8-5-10-32-22)24-20(12-26)19-9-11-31-15-21(19)23(27-24)18-6-3-4-7-18/h5,8,10,16-18H,3-4,6-7,9,11,13-15H2,1-2H3/t16-,17+	QPEOVXLGDXGFHU-CALCHBBNSA-N	326429	US9662327, Compound 126	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326429	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326429&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71477126	384581383							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642318	C[C@H]1CN(C[C@@H](C)N1C(=O)NC1CCCCC1)c1nc(C2CCCC2)c2COCCc2c1C#N	InChI=1S/C27H39N5O2/c1-18-15-31(16-19(2)32(18)27(33)29-21-10-4-3-5-11-21)26-23(14-28)22-12-13-34-17-24(22)25(30-26)20-8-6-7-9-20/h18-21H,3-13,15-17H2,1-2H3,(H,29,33)/t18-,19+	ZHOAEHRGYIRVHC-KDURUIRLSA-N	326430	US9662327, Compound 127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326430	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326430&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283074	384581384							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642319	C[C@H]1CN(C[C@@H](C)N1C(=O)c1ccco1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C26H32N4O3/c1-17-14-29(15-18(2)30(17)26(31)23-9-6-11-33-23)25-21(13-27)20-10-12-32-16-22(20)24(28-25)19-7-4-3-5-8-19/h6,9,11,17-19H,3-5,7-8,10,12,14-16H2,1-2H3/t17-,18+	TYHCMNRKEVMHMK-HDICACEKSA-N	326431	US9662327, Compound 128	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326431	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326431&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283247	384581385							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642320	Cc1ccoc1C(=O)N1CCN(CC1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C25H30N4O3/c1-17-7-14-32-23(17)25(30)29-11-9-28(10-12-29)24-20(15-26)19-8-13-31-16-21(19)22(27-24)18-5-3-2-4-6-18/h7,14,18H,2-6,8-13,16H2,1H3	GNOCNVJJHSEALP-UHFFFAOYSA-N	326432	US9662327, Compound 129	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326432	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326432&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282737	384581386							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642321	CC1CN(CCN1C(=O)c1ccoc1)c1nc(-c2cccc(F)c2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H27FN4O3/c1-17-14-31(8-9-32(17)26(33)19-7-10-34-15-19)25-22(13-29)21-12-27(2,3)35-16-23(21)24(30-25)18-5-4-6-20(28)11-18/h4-7,10-11,15,17H,8-9,12,14,16H2,1-3H3	MXCCYOJJNNGPAS-UHFFFAOYSA-N	326433	US9662327, Compound 130	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326433	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326433&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283105	384581387							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642322	O=C(Cc1ccccc1)N1CCN(CC1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C27H32N4O2/c28-18-23-22-11-16-33-19-24(22)26(21-9-5-2-6-10-21)29-27(23)31-14-12-30(13-15-31)25(32)17-20-7-3-1-4-8-20/h1,3-4,7-8,21H,2,5-6,9-17,19H2	QYXGCXSFVAQTGC-UHFFFAOYSA-N	326434	US9662327, Compound 131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326434	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326434&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283373	384581388							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642323	CC1CN(CCN1C(=O)c1ccco1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C25H30N4O3/c1-17-15-28(10-11-29(17)25(30)22-8-5-12-32-22)24-20(14-26)19-9-13-31-16-21(19)23(27-24)18-6-3-2-4-7-18/h5,8,12,17-18H,2-4,6-7,9-11,13,15-16H2,1H3	VBBOSRCEDDDLGL-UHFFFAOYSA-N	326435	US9662327, Compound 132	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326435	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326435&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282899	384581389							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642324	CC1CN(CCN1C(=O)c1ccoc1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C25H30N4O3/c1-17-14-28(9-10-29(17)25(30)19-7-11-31-15-19)24-21(13-26)20-8-12-32-16-22(20)23(27-24)18-5-3-2-4-6-18/h7,11,15,17-18H,2-6,8-10,12,14,16H2,1H3	UBHBVTSIPACZII-UHFFFAOYSA-N	326436	US9662327, Compound 133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326436	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326436&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282772	384581390							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642325	CC1CN(CCN1C(=O)c1ccc2[nH]ccc2c1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C29H33N5O2/c1-19-17-33(12-13-34(19)29(35)22-7-8-26-21(15-22)9-11-31-26)28-24(16-30)23-10-14-36-18-25(23)27(32-28)20-5-3-2-4-6-20/h7-9,11,15,19-20,31H,2-6,10,12-14,17-18H2,1H3	NCWVJWFHMXALRL-UHFFFAOYSA-N	326437	US9662327, Compound 134	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326437	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326437&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119625	384581391							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642326	CC1CN(CCN1C(=O)c1ccco1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H28N4O3/c1-15-13-27(8-9-28(15)23(29)20-5-4-10-30-20)22-18(12-25)17-11-24(2,3)31-14-19(17)21(26-22)16-6-7-16/h4-5,10,15-16H,6-9,11,13-14H2,1-3H3	UDLVOXLOJUCTPX-UHFFFAOYSA-N	326438	US9662327, Compound 135	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326438	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326438&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282764	384581392							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642327	CC1CN(CCN1C(=O)c1ccoc1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H28N4O3/c1-15-12-27(7-8-28(15)23(29)17-6-9-30-13-17)22-19(11-25)18-10-24(2,3)31-14-20(18)21(26-22)16-4-5-16/h6,9,13,15-16H,4-5,7-8,10,12,14H2,1-3H3	QEACWGNYZRVBET-UHFFFAOYSA-N	326439	US9662327, Compound 136	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326439	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326439&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166690	384581393							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642328	CC(C)c1nc(N2CCN(C(C)C2)C(=O)c2ccco2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C24H30N4O3/c1-15(2)21-19-14-31-24(4,5)11-17(19)18(12-25)22(26-21)27-8-9-28(16(3)13-27)23(29)20-7-6-10-30-20/h6-7,10,15-16H,8-9,11,13-14H2,1-5H3	QXGJEJYOXJJLLM-UHFFFAOYSA-N	326440	US9662327, Compound 137	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326440	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326440&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283014	384581394							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642329	CC(C)c1nc(N2CCN(C(C)C2)C(=O)c2ccoc2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C24H30N4O3/c1-15(2)21-20-14-31-24(4,5)10-18(20)19(11-25)22(26-21)27-7-8-28(16(3)12-27)23(29)17-6-9-30-13-17/h6,9,13,15-16H,7-8,10,12,14H2,1-5H3	IDURXWDRDNNXPO-UHFFFAOYSA-N	326441	US9662327, Compound 138	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326441	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326441&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119429	384581395							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642330	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)c2ccco2)c(C#N)c2CCOCc12	InChI=1S/C22H26N4O3/c1-14(2)20-18-13-28-10-6-16(18)17(11-23)21(24-20)25-7-8-26(15(3)12-25)22(27)19-5-4-9-29-19/h4-5,9,14-15H,6-8,10,12-13H2,1-3H3/t15-/m1/s1	FADJWABDDSRAGH-OAHLLOKOSA-N	326442	US9662327, Compound 139	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326442	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326442&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282827	384581396							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642331	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)c2ccoc2)c(C#N)c2CCOCc12	InChI=1S/C22H26N4O3/c1-14(2)20-19-13-29-9-5-17(19)18(10-23)21(24-20)25-6-7-26(15(3)11-25)22(27)16-4-8-28-12-16/h4,8,12,14-15H,5-7,9,11,13H2,1-3H3/t15-/m1/s1	WGRRSPMMUPVSKK-OAHLLOKOSA-N	326443	US9662327, Compound 140	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326443	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326443&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283037	384581397							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642332	O=C(C1CC1)N1CCN(CC1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C23H30N4O2/c24-14-19-18-8-13-29-15-20(18)21(16-4-2-1-3-5-16)25-22(19)26-9-11-27(12-10-26)23(28)17-6-7-17/h16-17H,1-13,15H2	AHNSPLGTQQAIBV-UHFFFAOYSA-N	326444	US9662327, Compound 141	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326444	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326444&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119479	384581398							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642333	CC1(C)Cc2c(CO1)c(nc(N1CCN(CC1)C(=O)c1ccco1)c2C#N)C1CC1	InChI=1S/C23H26N4O3/c1-23(2)12-16-17(13-24)21(25-20(15-5-6-15)18(16)14-30-23)26-7-9-27(10-8-26)22(28)19-4-3-11-29-19/h3-4,11,15H,5-10,12,14H2,1-2H3	OOIHYQJVEVBYCV-UHFFFAOYSA-N	326445	US9662327, Compound 142	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326445	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326445&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283204	384581399							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642334	CC1(C)Cc2c(CO1)c(nc(N1CCN(C(C1)c1ccccc1)C(=O)c1ccoc1)c2C#N)C1CCCCC1	InChI=1S/C32H36N4O3/c1-32(2)17-25-26(18-33)30(34-29(27(25)21-39-32)23-11-7-4-8-12-23)35-14-15-36(31(37)24-13-16-38-20-24)28(19-35)22-9-5-3-6-10-22/h3,5-6,9-10,13,16,20,23,28H,4,7-8,11-12,14-15,17,19,21H2,1-2H3	URMRNSZPIMBIMW-UHFFFAOYSA-N	326446	US9662327, Compound 143	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326446	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326446&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282850	384581400							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642335	CC(C)c1nc(N2CCN(CC2)C(=O)Cc2ccccc2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C26H32N4O2/c1-18(2)24-22-17-32-26(3,4)15-20(22)21(16-27)25(28-24)30-12-10-29(11-13-30)23(31)14-19-8-6-5-7-9-19/h5-9,18H,10-15,17H2,1-4H3	UOTHFUJKQWEANR-UHFFFAOYSA-N	326447	US9662327, Compound 144	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326447	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326447&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283254	384581401							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642336	CC(C)c1nc(N2CCN(CC2)C(=O)Cc2cccs2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C24H30N4O2S/c1-16(2)22-20-15-30-24(3,4)13-18(20)19(14-25)23(26-22)28-9-7-27(8-10-28)21(29)12-17-6-5-11-31-17/h5-6,11,16H,7-10,12-13,15H2,1-4H3	LJJWVMBHEIUBGE-UHFFFAOYSA-N	326448	US9662327, Compound 145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326448	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326448&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282765	384581402							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642337	C[C@H]1CN(C[C@@H](C)N1C(=O)c1ccoc1)c1nc(C2CCCC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H34N4O3/c1-17-13-30(14-18(2)31(17)26(32)20-9-10-33-15-20)25-22(12-28)21-11-27(3,4)34-16-23(21)24(29-25)19-7-5-6-8-19/h9-10,15,17-19H,5-8,11,13-14,16H2,1-4H3/t17-,18+	VMPTXHHJJULQBX-HDICACEKSA-N	326449	US9662327, Compound 146	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326449	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326449&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282629	384581403							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642338	CC1CN(CCN1C(=O)c1ccco1)c1nc(C2CCCC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H32N4O3/c1-17-15-29(10-11-30(17)25(31)22-9-6-12-32-22)24-20(14-27)19-13-26(2,3)33-16-21(19)23(28-24)18-7-4-5-8-18/h6,9,12,17-18H,4-5,7-8,10-11,13,15-16H2,1-3H3	ZEELJJJWDYMSAY-UHFFFAOYSA-N	326450	US9662327, Compound 147	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326450	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326450&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283272	384581404							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642339	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)c2ccco2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C24H30N4O3/c1-15(2)21-19-14-31-24(4,5)11-17(19)18(12-25)22(26-21)27-8-9-28(16(3)13-27)23(29)20-7-6-10-30-20/h6-7,10,15-16H,8-9,11,13-14H2,1-5H3/t16-/m1/s1	QXGJEJYOXJJLLM-MRXNPFEDSA-N	326451	US9662327, Compound 148	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326451	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326451&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283012	384581405							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642340	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)c2ccoc2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C24H30N4O3/c1-15(2)21-20-14-31-24(4,5)10-18(20)19(11-25)22(26-21)27-7-8-28(16(3)12-27)23(29)17-6-9-30-13-17/h6,9,13,15-16H,7-8,10,12,14H2,1-5H3/t16-/m1/s1	IDURXWDRDNNXPO-MRXNPFEDSA-N	326452	US9662327, Compound 149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326452	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326452&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282706	384581406							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642341	C[C@@H]1CN(CCN1C(=O)c1ccco1)c1nc(C2CCCCC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C27H36N4O3/c1-18-16-30(11-12-31(18)26(32)23-10-7-13-33-23)25-21(15-28)20-14-27(2,3)34-17-22(20)24(29-25)19-8-5-4-6-9-19/h7,10,13,15,18-19,28H,4-6,8-9,11-12,14,16-17H2,1-3H3/t18-/m1/s1	MOOBAIYUORDPBW-GOSISDBHSA-N	326453	US9662327, Compound 150	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326453	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326453&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295074	384581407							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642342	C[C@@H]1CN(CCN1C(=O)c1ccoc1)c1nc(C2CCCCC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C27H36N4O3/c1-18-15-30(10-11-31(18)26(32)20-9-12-33-16-20)25-22(14-28)21-13-27(2,3)34-17-23(21)24(29-25)19-7-5-4-6-8-19/h9,12,14,16,18-19,28H,4-8,10-11,13,15,17H2,1-3H3/t18-/m1/s1	PSUFCTJFPWFVRL-GOSISDBHSA-N	326454	US9662327, Compound 151	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326454	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326454&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295065	384581408							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642343	C[C@@H]1CN(CCN1C(=O)Cc1ccccc1)c1nc(C2CCCCC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C30H38N4O2/c1-21-19-33(14-15-34(21)27(35)16-22-10-6-4-7-11-22)29-25(18-31)24-17-30(2,3)36-20-26(24)28(32-29)23-12-8-5-9-13-23/h4,6-7,10-11,21,23H,5,8-9,12-17,19-20H2,1-3H3/t21-/m1/s1	LWRAGQKEPAADQJ-OAQYLSRUSA-N	326455	US9662327, Compound 152	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326455	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326455&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282819	384581409							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642344	C[C@@H]1CN(CCN1C(=O)Cc1cccs1)c1nc(C2CCCCC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C28H36N4O2S/c1-19-17-31(11-12-32(19)25(33)14-21-10-7-13-35-21)27-23(16-29)22-15-28(2,3)34-18-24(22)26(30-27)20-8-5-4-6-9-20/h7,10,13,19-20H,4-6,8-9,11-12,14-15,17-18H2,1-3H3/t19-/m1/s1	PANAKEGCLLUKPA-LJQANCHMSA-N	326456	US9662327, Compound 153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326456	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326456&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71477127	384581410							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642345	CC(C)c1nc(N2CCN(C(O)c3ccco3)C(C2)c2ccccc2)c(C=N)c2CC(C)(C)OCc12	InChI=1S/C29H36N4O3/c1-19(2)26-23-18-36-29(3,4)15-21(23)22(16-30)27(31-26)32-12-13-33(28(34)25-11-8-14-35-25)24(17-32)20-9-6-5-7-10-20/h5-11,14,16,19,24,28,30,34H,12-13,15,17-18H2,1-4H3	TXMZNLVKZLWHFI-UHFFFAOYSA-N	326457	US9662327, Compound 154	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326457	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326457&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295075	384581411							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642346	CC(C)c1nc(N2CCN(C(C2)c2ccccc2)C(=O)c2ccoc2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C29H32N4O3/c1-19(2)26-24-18-36-29(3,4)14-22(24)23(15-30)27(31-26)32-11-12-33(28(34)21-10-13-35-17-21)25(16-32)20-8-6-5-7-9-20/h5-10,13,17,19,25H,11-12,14,16,18H2,1-4H3	VYOCJCUGCJATIM-UHFFFAOYSA-N	326458	US9662327, Compound 155	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326458	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326458&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282662	384581412							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642347	CC1(C)Cc2c(CO1)c(nc(N1CCN(C(C1)c1ccccc1)C(=O)c1ccoc1)c2C#N)C1CC1	InChI=1S/C29H30N4O3/c1-29(2)14-22-23(15-30)27(31-26(20-8-9-20)24(22)18-36-29)32-11-12-33(28(34)21-10-13-35-17-21)25(16-32)19-6-4-3-5-7-19/h3-7,10,13,17,20,25H,8-9,11-12,14,16,18H2,1-2H3	LQRQGQQFPCRRAA-UHFFFAOYSA-N	326459	US9662327, Compound 156	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326459	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326459&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282994	384581413							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642348	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)C(=O)c2ccccc2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C27H32N4O3/c1-17(2)23-22-16-34-27(4,5)13-20(22)21(14-28)25(29-23)30-11-12-31(18(3)15-30)26(33)24(32)19-9-7-6-8-10-19/h6-10,17-18H,11-13,15-16H2,1-5H3/t18-/m1/s1	PJCDVBCBZLFBBB-GOSISDBHSA-N	326460	US9662327, Compound 157	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326460	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326460&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283593	384581414							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642349	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)Cc2cccs2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C25H32N4O2S/c1-16(2)23-21-15-31-25(4,5)12-19(21)20(13-26)24(27-23)28-8-9-29(17(3)14-28)22(30)11-18-7-6-10-32-18/h6-7,10,16-17H,8-9,11-12,14-15H2,1-5H3/t17-/m1/s1	NWBUGGOTZIREFX-QGZVFWFLSA-N	326461	US9662327, Compound 158::US9662327, Compound 231	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326461	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326461&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283288	384581415							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642350	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)Cc2cc(F)cc(F)c2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C27H32F2N4O2/c1-16(2)25-23-15-35-27(4,5)12-21(23)22(13-30)26(31-25)32-6-7-33(17(3)14-32)24(34)10-18-8-19(28)11-20(29)9-18/h8-9,11,16-17H,6-7,10,12,14-15H2,1-5H3/t17-/m1/s1	BWQGTSVPUTWBIU-QGZVFWFLSA-N	326462	US9662327, Compound 159	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326462	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326462&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282707	384581416							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642351	C[C@@H]1CN(CCN1C(=O)c1ccoc1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C25H30N4O3/c1-17-14-28(9-10-29(17)25(30)19-7-11-31-15-19)24-21(13-26)20-8-12-32-16-22(20)23(27-24)18-5-3-2-4-6-18/h7,11,15,17-18H,2-6,8-10,12,14,16H2,1H3/t17-/m1/s1	UBHBVTSIPACZII-QGZVFWFLSA-N	326463	US9662327, Compound 160	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326463	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326463&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282770	384581417							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642352	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)Cc2cccc(Cl)c2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C27H33ClN4O2/c1-17(2)25-23-16-34-27(4,5)13-21(23)22(14-29)26(30-25)31-9-10-32(18(3)15-31)24(33)12-19-7-6-8-20(28)11-19/h6-8,11,17-18H,9-10,12-13,15-16H2,1-5H3/t18-/m1/s1	DMUAEJMGOMLRPW-GOSISDBHSA-N	326464	US9662327, Compound 161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326464	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326464&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283104	384581418							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642353	C[C@@H]1CN(CCN1C(=O)c1ccco1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C25H30N4O3/c1-17-15-28(10-11-29(17)25(30)22-8-5-12-32-22)24-20(14-26)19-9-13-31-16-21(19)23(27-24)18-6-3-2-4-7-18/h5,8,12,17-18H,2-4,6-7,9-11,13,15-16H2,1H3/t17-/m1/s1	VBBOSRCEDDDLGL-QGZVFWFLSA-N	326465	US9662327, Compound 162	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326465	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326465&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283359	384581419							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642354	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)c2ccoc2C)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C25H32N4O3/c1-15(2)22-21-14-32-25(5,6)11-19(21)20(12-26)23(27-22)28-8-9-29(16(3)13-28)24(30)18-7-10-31-17(18)4/h7,10,15-16H,8-9,11,13-14H2,1-6H3/t16-/m1/s1	IXGHEAIYDLBSEI-MRXNPFEDSA-N	326466	US9662327, Compound 163	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326466	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326466&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282908	384581420							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642355	C[C@@H]1CN(CCN1C(=O)c1ccoc1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H28N4O3/c1-15-12-27(7-8-28(15)23(29)17-6-9-30-13-17)22-19(11-25)18-10-24(2,3)31-14-20(18)21(26-22)16-4-5-16/h6,9,13,15-16H,4-5,7-8,10,12,14H2,1-3H3/t15-/m1/s1	QEACWGNYZRVBET-OAHLLOKOSA-N	326467	US9662327, Compound 164	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326467	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326467&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166689	384581421							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642356	CC(C)[C@@H]1CN(CCN1C(=O)c1ccoc1)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H34N4O3/c1-16(2)22-13-29(8-9-30(22)25(31)18-7-10-32-14-18)24-20(12-27)19-11-26(5,6)33-15-21(19)23(28-24)17(3)4/h7,10,14,16-17,22H,8-9,11,13,15H2,1-6H3/t22-/m0/s1	SUYUBBKNAQSURK-QFIPXVFZSA-N	326468	US9662327, Compound 165	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326468	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326468&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283214	384581422							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642357	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)c2ccc(Cl)cc2Cl)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C26H30Cl2N4O2/c1-15(2)23-21-14-34-26(4,5)11-19(21)20(12-29)24(30-23)31-8-9-32(16(3)13-31)25(33)18-7-6-17(27)10-22(18)28/h6-7,10,15-16H,8-9,11,13-14H2,1-5H3/t16-/m1/s1	SLGZSWPROQJWRP-MRXNPFEDSA-N	326469	US9662327, Compound 166	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326469	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326469&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283152	384581423							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642358	C[C@@H]1CN(CCN1C(=O)c1ccco1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H28N4O3/c1-15-13-27(8-9-28(15)23(29)20-5-4-10-30-20)22-18(12-25)17-11-24(2,3)31-14-19(17)21(26-22)16-6-7-16/h4-5,10,15-16H,6-9,11,13-14H2,1-3H3/t15-/m1/s1	UDLVOXLOJUCTPX-OAHLLOKOSA-N	326470	US9662327, Compound 167	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326470	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326470&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295069	384581424							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642359	CC1CN(CCN1C(=O)c1ccco1)c1nc(C2CCCCC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H34N4O3/c1-18-16-30(11-12-31(18)26(32)23-10-7-13-33-23)25-21(15-28)20-14-27(2,3)34-17-22(20)24(29-25)19-8-5-4-6-9-19/h7,10,13,18-19H,4-6,8-9,11-12,14,16-17H2,1-3H3	TUCTYVHWXPNMQN-UHFFFAOYSA-N	326471	US9662327, Compound 168	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326471	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326471&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282687	384581425							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642360	CC1CN(CCN1C(=O)c1ccoc1)c1nc(C2CCCCC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H34N4O3/c1-18-15-30(10-11-31(18)26(32)20-9-12-33-16-20)25-22(14-28)21-13-27(2,3)34-17-23(21)24(29-25)19-7-5-4-6-8-19/h9,12,16,18-19H,4-8,10-11,13,15,17H2,1-3H3	ZUHBIMLHOSMEKY-UHFFFAOYSA-N	326472	US9662327, Compound 169	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326472	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326472&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282871	384581426							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642361	CC(C)c1nc(N2CCN([C@H](C)C2)S(=O)(=O)c2cccs2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C23H30N4O3S2/c1-15(2)21-19-14-30-23(4,5)11-17(19)18(12-24)22(25-21)26-8-9-27(16(3)13-26)32(28,29)20-7-6-10-31-20/h6-7,10,15-16H,8-9,11,13-14H2,1-5H3/t16-/m1/s1	POMHHUVQINPVOK-MRXNPFEDSA-N	326473	US9662327, Compound 170	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326473	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326473&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282634	384581427							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642362	CC(C)[C@@H]1CN(CCN1C(=O)c1ccco1)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H34N4O3/c1-16(2)21-14-29(9-10-30(21)25(31)22-8-7-11-32-22)24-19(13-27)18-12-26(5,6)33-15-20(18)23(28-24)17(3)4/h7-8,11,16-17,21H,9-10,12,14-15H2,1-6H3/t21-/m0/s1	RYKUPWRLDJDAOB-NRFANRHFSA-N	326474	US9662327, Compound 171	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326474	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326474&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283242	384581428							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642363	CCC1CN(CCN1C(=O)c1ccoc1)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H32N4O3/c1-6-18-13-28(8-9-29(18)24(30)17-7-10-31-14-17)23-20(12-26)19-11-25(4,5)32-15-21(19)22(27-23)16(2)3/h7,10,14,16,18H,6,8-9,11,13,15H2,1-5H3	FIMIBPGJNQDFPW-UHFFFAOYSA-N	326475	US9662327, Compound 172	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326475	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326475&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282666	384581429							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642364	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)c2occc2C)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C25H32N4O3/c1-15(2)21-20-14-32-25(5,6)11-18(20)19(12-26)23(27-21)28-8-9-29(17(4)13-28)24(30)22-16(3)7-10-31-22/h7,10,15,17H,8-9,11,13-14H2,1-6H3/t17-/m1/s1	PEQGJPYLAVFKEM-QGZVFWFLSA-N	326476	US9662327, Compound 173	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326476	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326476&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282609	384581430							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642365	CCC1CN(CCN1C(=O)c1ccco1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C26H32N4O3/c1-2-19-16-29(11-12-30(19)26(31)23-9-6-13-33-23)25-21(15-27)20-10-14-32-17-22(20)24(28-25)18-7-4-3-5-8-18/h6,9,13,18-19H,2-5,7-8,10-12,14,16-17H2,1H3	WOZLNSRNSZVBSR-UHFFFAOYSA-N	326477	US9662327, Compound 174	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326477	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326477&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282924	384581431							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642366	CCC1CN(CCN1C(=O)c1ccoc1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C26H32N4O3/c1-2-20-15-29(10-11-30(20)26(31)19-8-12-32-16-19)25-22(14-27)21-9-13-33-17-23(21)24(28-25)18-6-4-3-5-7-18/h8,12,16,18,20H,2-7,9-11,13,15,17H2,1H3	VDCLNFPGFFBXDW-UHFFFAOYSA-N	326478	US9662327, Compound 175	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326478	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326478&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118466	384581432							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642367	CC(C)[C@@H]1CN(CCN1C(=O)c1ccoc1C)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H36N4O3/c1-16(2)23-14-30(9-10-31(23)26(32)19-8-11-33-18(19)5)25-21(13-28)20-12-27(6,7)34-15-22(20)24(29-25)17(3)4/h8,11,16-17,23H,9-10,12,14-15H2,1-7H3/t23-/m0/s1	JJRGFLHJPGYGFC-QHCPKHFHSA-N	326479	US9662327, Compound 176	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326479	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326479&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283095	384581433							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642368	CC(C)c1nc(N2CCN(CC2c2ccccc2)C(=O)c2ccoc2C)c(C#N)c2CCOCc12	InChI=1S/C28H30N4O3/c1-18(2)26-24-17-34-13-9-22(24)23(15-29)27(30-26)32-12-11-31(28(33)21-10-14-35-19(21)3)16-25(32)20-7-5-4-6-8-20/h4-8,10,14,18,25H,9,11-13,16-17H2,1-3H3	ATCLQLMHNAAXFH-UHFFFAOYSA-N	326480	US9662327, Compound 177	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326480	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326480&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119557	384581434							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642369	CC(C)c1nc(N2CCN(CC2c2ccccc2)C(=O)c2ccoc2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C29H32N4O3/c1-19(2)26-24-18-36-29(3,4)14-22(24)23(15-30)27(31-26)33-12-11-32(28(34)21-10-13-35-17-21)16-25(33)20-8-6-5-7-9-20/h5-10,13,17,19,25H,11-12,14,16,18H2,1-4H3	AUPLTCGJPXEXKR-UHFFFAOYSA-N	326481	US9662327, Compound 178	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326481	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326481&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282798	384581435							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642370	CC(C)c1nc(N2CCN(CC2c2ccccc2)C(=O)c2ccoc2C)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C30H34N4O3/c1-19(2)27-25-18-37-30(4,5)15-23(25)24(16-31)28(32-27)34-13-12-33(29(35)22-11-14-36-20(22)3)17-26(34)21-9-7-6-8-10-21/h6-11,14,19,26H,12-13,15,17-18H2,1-5H3	KPIQYAZGGREOHT-UHFFFAOYSA-N	326482	US9662327, Compound 179	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326482	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326482&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282914	384581436							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642371	CC(C)[C@@H]1CN(CCN1C(=O)c1ccoc1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C26H34N4O3/c1-16(2)22-13-29(8-9-30(22)25(31)18-7-10-32-14-18)24-20(12-27)19-11-26(3,4)33-15-21(19)23(28-24)17-5-6-17/h7,10,12,14,16-17,22,27H,5-6,8-9,11,13,15H2,1-4H3/t22-/m0/s1	FRLSFSXXILGVSZ-QFIPXVFZSA-N	326483	US9662327, Compound 180	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326483	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326483&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295077	384581437							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642372	CC(C)[C@@H]1CN(CCN1C(=O)c1ccoc1C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H34N4O3/c1-16(2)23-14-30(9-10-31(23)26(32)19-8-11-33-17(19)3)25-21(13-28)20-12-27(4,5)34-15-22(20)24(29-25)18-6-7-18/h8,11,16,18,23H,6-7,9-10,12,14-15H2,1-5H3/t23-/m0/s1	JCDNESOQVJEGKC-QHCPKHFHSA-N	326484	US9662327, Compound 181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326484	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326484&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295079	384581438							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642373	CC(C)[C@@H]1CN(CCN1C(=O)c1ccco1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C27H34N4O3/c1-18(2)23-16-30(11-12-31(23)27(32)24-9-6-13-34-24)26-21(15-28)20-10-14-33-17-22(20)25(29-26)19-7-4-3-5-8-19/h6,9,13,18-19,23H,3-5,7-8,10-12,14,16-17H2,1-2H3/t23-/m0/s1	FDVCFHUHUZBYOA-QHCPKHFHSA-N	326485	US9662327, Compound 182	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326485	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326485&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119595	384581439							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642374	CC(C)[C@@H]1CN(CCN1C(=O)c1ccoc1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C27H34N4O3/c1-18(2)24-15-30(10-11-31(24)27(32)20-8-12-33-16-20)26-22(14-28)21-9-13-34-17-23(21)25(29-26)19-6-4-3-5-7-19/h8,12,16,18-19,24H,3-7,9-11,13,15,17H2,1-2H3/t24-/m0/s1	VUVXLSXTHHMYEA-DEOSSOPVSA-N	326486	US9662327, Compound 183	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326486	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326486&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119055	384581440							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642375	C[C@@H]1CN(CCN1C(=O)c1ccoc1C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C26H32N4O3/c1-17-15-29(10-11-30(17)26(31)20-9-13-33-18(20)2)25-22(14-27)21-8-12-32-16-23(21)24(28-25)19-6-4-3-5-7-19/h9,13,17,19H,3-8,10-12,15-16H2,1-2H3/t17-/m1/s1	MEHGDFHTOWYZMR-QGZVFWFLSA-N	326487	US9662327, Compound 184	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326487	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326487&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283071	384581441							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642376	C[C@@H]1CN(CCN1C(=O)Cc1cccs1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C26H32N4O2S/c1-18-16-29(10-11-30(18)24(31)14-20-8-5-13-33-20)26-22(15-27)21-9-12-32-17-23(21)25(28-26)19-6-3-2-4-7-19/h5,8,13,18-19H,2-4,6-7,9-12,14,16-17H2,1H3/t18-/m1/s1	UQQJOZMQIKDUIC-GOSISDBHSA-N	326488	US9662327, Compound 185	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326488	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326488&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282842	384581442							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642377	C[C@@H]1CN(CCN1C(=O)c1occc1C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C26H32N4O3/c1-17-8-13-33-24(17)26(31)30-11-10-29(15-18(30)2)25-21(14-27)20-9-12-32-16-22(20)23(28-25)19-6-4-3-5-7-19/h8,13,18-19H,3-7,9-12,15-16H2,1-2H3/t18-/m1/s1	PRVVIRHIDALJPV-GOSISDBHSA-N	326489	US9662327, Compound 186	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326489	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326489&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282855	384581443							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642378	C[C@@H]1CN(CCN1C(=O)c1cnoc1C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C25H31N5O3/c1-16-14-29(9-10-30(16)25(31)21-13-27-33-17(21)2)24-20(12-26)19-8-11-32-15-22(19)23(28-24)18-6-4-3-5-7-18/h13,16,18H,3-11,14-15H2,1-2H3/t16-/m1/s1	DGASUZFXGFAPTO-MRXNPFEDSA-N	326490	US9662327, Compound 187	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326490	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326490&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71477128	384581444							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642379	C[C@@H]1CN(CCN1C(=O)Cc1ccccc1F)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C28H33FN4O2/c1-19-17-32(12-13-33(19)26(34)15-21-9-5-6-10-25(21)29)28-23(16-30)22-11-14-35-18-24(22)27(31-28)20-7-3-2-4-8-20/h5-6,9-10,19-20H,2-4,7-8,11-15,17-18H2,1H3/t19-/m1/s1	BOHHUQOJBIENPA-LJQANCHMSA-N	326491	US9662327, Compound 188	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326491	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326491&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119606	384581445							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642380	COc1cccc(CC(=O)N2CCN(C[C@H]2C)c2nc(C3CCCCC3)c3COCCc3c2C#N)c1	InChI=1S/C29H36N4O3/c1-20-18-32(12-13-33(20)27(34)16-21-7-6-10-23(15-21)35-2)29-25(17-30)24-11-14-36-19-26(24)28(31-29)22-8-4-3-5-9-22/h6-7,10,15,20,22H,3-5,8-9,11-14,16,18-19H2,1-2H3/t20-/m1/s1	HWAGNAVPUFYBFN-HXUWFJFHSA-N	326492	US9662327, Compound 189	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326492	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326492&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119445	384581446							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642381	C[C@@H]1CN(CCN1C(=O)c1c(C)nc2ccccn12)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C29H34N6O2/c1-19-17-33(13-14-34(19)29(36)27-20(2)31-25-10-6-7-12-35(25)27)28-23(16-30)22-11-15-37-18-24(22)26(32-28)21-8-4-3-5-9-21/h6-7,10,12,19,21H,3-5,8-9,11,13-15,17-18H2,1-2H3/t19-/m1/s1	CNEQGBIBBHMGAK-LJQANCHMSA-N	326493	US9662327, Compound 190	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326493	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326493&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283276	384581447							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642382	C[C@@H]1CN(CCN1C(=O)Cc1cccc(F)c1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C28H33FN4O2/c1-19-17-32(11-12-33(19)26(34)15-20-6-5-9-22(29)14-20)28-24(16-30)23-10-13-35-18-25(23)27(31-28)21-7-3-2-4-8-21/h5-6,9,14,19,21H,2-4,7-8,10-13,15,17-18H2,1H3/t19-/m1/s1	AVQCQCXTWAAUIK-LJQANCHMSA-N	326494	US9662327, Compound 191	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326494	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326494&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119209	384581448							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642383	CC(C)[C@@H]1CN(CCN1C(=O)c1ccco1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C26H34N4O3/c1-16(2)21-14-29(9-10-30(21)25(31)22-6-5-11-32-22)24-19(13-27)18-12-26(3,4)33-15-20(18)23(28-24)17-7-8-17/h5-6,11,13,16-17,21,27H,7-10,12,14-15H2,1-4H3/t21-/m0/s1	KZDOBDYMIPDXIP-NRFANRHFSA-N	326495	US9662327, Compound 192	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326495	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326495&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295080	384581449							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642384	CC(C)[C@@H]1CN(CCN1C(=O)c1occc1C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H34N4O3/c1-16(2)22-14-30(9-10-31(22)26(32)24-17(3)8-11-33-24)25-20(13-28)19-12-27(4,5)34-15-21(19)23(29-25)18-6-7-18/h8,11,16,18,22H,6-7,9-10,12,14-15H2,1-5H3/t22-/m0/s1	WKIKPYKGLRRYBU-QFIPXVFZSA-N	326496	US9662327, Compound 193	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326496	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326496&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295083	384581450							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642385	CC(C)[C@@H]1CN(CCN1C(=O)Cc1cccs1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H34N4O2S/c1-17(2)23-15-30(9-10-31(23)24(32)12-19-6-5-11-34-19)26-21(14-28)20-13-27(3,4)33-16-22(20)25(29-26)18-7-8-18/h5-6,11,17-18,23H,7-10,12-13,15-16H2,1-4H3/t23-/m0/s1	RACLIFZFOBRIRG-QHCPKHFHSA-N	326497	US9662327, Compound 194	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326497	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326497&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295082	384581451							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642386	CC(C)[C@@H]1CN(CCN1C(=O)Cc1cccs1)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H36N4O2S/c1-17(2)23-15-30(9-10-31(23)24(32)12-19-8-7-11-34-19)26-21(14-28)20-13-27(5,6)33-16-22(20)25(29-26)18(3)4/h7-8,11,17-18,23H,9-10,12-13,15-16H2,1-6H3/t23-/m0/s1	LHWCDRJDXQALCQ-QHCPKHFHSA-N	326498	US9662327, Compound 195	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326498	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326498&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283259	384581452							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642387	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)c2cc(C)oc2C)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C26H34N4O3/c1-15(2)23-22-14-32-26(6,7)11-20(22)21(12-27)24(28-23)29-8-9-30(16(3)13-29)25(31)19-10-17(4)33-18(19)5/h10,15-16H,8-9,11,13-14H2,1-7H3/t16-/m1/s1	WCPPJEAQDUGCFI-MRXNPFEDSA-N	326499	US9662327, Compound 196	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326499	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326499&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282796	384581453							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642388	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)c2ocnc2C)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C24H31N5O3/c1-14(2)20-19-12-32-24(5,6)9-17(19)18(10-25)22(27-20)28-7-8-29(15(3)11-28)23(30)21-16(4)26-13-31-21/h13-15H,7-9,11-12H2,1-6H3/t15-/m1/s1	KXHXAXQPNOTNBD-OAHLLOKOSA-N	326500	US9662327, Compound 197	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326500	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326500&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282694	384581454							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642389	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)c2cocn2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C23H29N5O3/c1-14(2)20-18-11-31-23(4,5)8-16(18)17(9-24)21(26-20)27-6-7-28(15(3)10-27)22(29)19-12-30-13-25-19/h12-15H,6-8,10-11H2,1-5H3/t15-/m1/s1	SLACPRJTUOEKLD-OAHLLOKOSA-N	326501	US9662327, Compound 198	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326501	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326501&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282995	384581455							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642390	COc1ccccc1CC(=O)N1CCN(C[C@H]1C)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C28H36N4O3/c1-18(2)26-23-17-35-28(4,5)14-21(23)22(15-29)27(30-26)31-11-12-32(19(3)16-31)25(33)13-20-9-7-8-10-24(20)34-6/h7-10,18-19H,11-14,16-17H2,1-6H3/t19-/m1/s1	MQWOGQNLQBFWBU-LJQANCHMSA-N	326502	US9662327, Compound 199	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326502	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326502&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71477129	384581456							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642391	CC(C)c1nc(N2CCN(C(O)c3ccco3)[C@@H](C2)c2ccccc2)c(C=N)c2CC(C)(C)OCc12	InChI=1S/C29H36N4O3/c1-19(2)26-23-18-36-29(3,4)15-21(23)22(16-30)27(31-26)32-12-13-33(28(34)25-11-8-14-35-25)24(17-32)20-9-6-5-7-10-20/h5-11,14,16,19,24,28,30,34H,12-13,15,17-18H2,1-4H3/t24-,28?/m0/s1	TXMZNLVKZLWHFI-ZZDYIDRTSA-N	326503	US9662327, Compound 200	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326503	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326503&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295084	384581457							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642392	C[C@H]1CN(CCN1c1nc(C2CCCCC2)c2COCCc2c1C#N)C(=O)c1ccco1	InChI=1S/C25H30N4O3/c1-17-15-28(25(30)22-8-5-12-32-22)10-11-29(17)24-20(14-26)19-9-13-31-16-21(19)23(27-24)18-6-3-2-4-7-18/h5,8,12,17-18H,2-4,6-7,9-11,13,15-16H2,1H3/t17-/m0/s1	WCQWCZGCWJHXNH-KRWDZBQOSA-N	326504	US9662327, Compound 201	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326504	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326504&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282584	384581458							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642393	CC(C)c1nc(N2CCN(C[C@@H]2C)C(=O)c2ccco2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C24H30N4O3/c1-15(2)21-19-14-31-24(4,5)11-17(19)18(12-25)22(26-21)28-9-8-27(13-16(28)3)23(29)20-7-6-10-30-20/h6-7,10,15-16H,8-9,11,13-14H2,1-5H3/t16-/m0/s1	QEIIATCRDLMVHT-INIZCTEOSA-N	326505	US9662327, Compound 202	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326505	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326505&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283270	384581459							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642394	C[C@H]1CN(CCN1c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N)C(=O)c1ccco1	InChI=1S/C24H28N4O3/c1-15-13-27(23(29)20-5-4-10-30-20)8-9-28(15)22-18(12-25)17-11-24(2,3)31-14-19(17)21(26-22)16-6-7-16/h4-5,10,15-16H,6-9,11,13-14H2,1-3H3/t15-/m0/s1	VAKFJIWLNPOVRC-HNNXBMFYSA-N	326506	US9662327, Compound 203	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326506	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326506&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282761	384581460							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642395	C[C@@H]1CN(CCN1c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N)C(=O)c1ccco1	InChI=1S/C24H28N4O3/c1-15-13-27(23(29)20-5-4-10-30-20)8-9-28(15)22-18(12-25)17-11-24(2,3)31-14-19(17)21(26-22)16-6-7-16/h4-5,10,15-16H,6-9,11,13-14H2,1-3H3/t15-/m1/s1	VAKFJIWLNPOVRC-OAHLLOKOSA-N	326507	US9662327, Compound 204	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326507	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326507&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282808	384581461							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642396	CC[C@@H]1CN(CCN1C(=O)c1ccoc1)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H32N4O3/c1-6-18-13-28(8-9-29(18)24(30)17-7-10-31-14-17)23-20(12-26)19-11-25(4,5)32-15-21(19)22(27-23)16(2)3/h7,10,14,16,18H,6,8-9,11,13,15H2,1-5H3/t18-/m1/s1	FIMIBPGJNQDFPW-GOSISDBHSA-N	326508	US9662327, Compound 205	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326508	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326508&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282795	384581462							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642397	CC[C@@H]1CN(CCN1C(=O)Cc1cccs1)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H34N4O2S/c1-6-18-15-29(9-10-30(18)23(31)12-19-8-7-11-33-19)25-21(14-27)20-13-26(4,5)32-16-22(20)24(28-25)17(2)3/h7-8,11,17-18H,6,9-10,12-13,15-16H2,1-5H3/t18-/m1/s1	JKCVDHFLZJLOPM-GOSISDBHSA-N	326509	US9662327, Compound 206	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326509	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326509&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282788	384581463							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642398	CC[C@@H]1CN(CCN1C(=O)c1ccoc1C)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H34N4O3/c1-7-18-14-29(9-10-30(18)25(31)19-8-11-32-17(19)4)24-21(13-27)20-12-26(5,6)33-15-22(20)23(28-24)16(2)3/h8,11,16,18H,7,9-10,12,14-15H2,1-6H3/t18-/m1/s1	IOKZMYMNOZSOPC-GOSISDBHSA-N	326510	US9662327, Compound 207	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326510	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326510&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282655	384581464							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642399	COc1ccccc1CC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C30H38N4O3/c1-19(2)25-17-33(12-13-34(25)27(35)14-21-8-6-7-9-26(21)36-5)29-23(16-31)22-15-30(3,4)37-18-24(22)28(32-29)20-10-11-20/h6-9,19-20,25H,10-15,17-18H2,1-5H3/t25-/m0/s1	IXDBEUGYIXHRGG-VWLOTQADSA-N	326511	US9662327, Compound 208	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326511	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326511&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295087	384581465							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642400	CC(C)[C@@H]1CN(CCN1C(=O)c1cocn1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C25H33N5O3/c1-15(2)21-11-29(7-8-30(21)24(31)20-13-32-14-27-20)23-18(10-26)17-9-25(3,4)33-12-19(17)22(28-23)16-5-6-16/h10,13-16,21,26H,5-9,11-12H2,1-4H3/t21-/m0/s1	ZJHGZUPKADFFNP-NRFANRHFSA-N	326512	US9662327, Compound 209	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326512	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326512&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295088	384581466							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642401	CC(C)[C@@H]1CN(CCN1C(=O)c1ocnc1C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C26H35N5O3/c1-15(2)21-12-30(8-9-31(21)25(32)23-16(3)28-14-33-23)24-19(11-27)18-10-26(4,5)34-13-20(18)22(29-24)17-6-7-17/h11,14-15,17,21,27H,6-10,12-13H2,1-5H3/t21-/m0/s1	PDDIRLZEWOZURM-NRFANRHFSA-N	326513	US9662327, Compound 210	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326513	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326513&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295089	384581467							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642402	CC(C)[C@@H]1CN(CCN1C(=O)Cc1ccccn1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C28H35N5O2/c1-18(2)24-16-32(11-12-33(24)25(34)13-20-7-5-6-10-30-20)27-22(15-29)21-14-28(3,4)35-17-23(21)26(31-27)19-8-9-19/h5-7,10,18-19,24H,8-9,11-14,16-17H2,1-4H3/t24-/m0/s1	CRVIZHLVIZXPET-DEOSSOPVSA-N	326514	US9662327, Compound 211	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326514	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326514&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71477130	384581468							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642403	CC(C)[C@@H]1CN(CCN1C(=O)c1cocn1)c1nc(C(C)C)c2COC(C)(C)Cc2c1C=N	InChI=1S/C25H35N5O3/c1-15(2)21-11-29(7-8-30(21)24(31)20-13-32-14-27-20)23-18(10-26)17-9-25(5,6)33-12-19(17)22(28-23)16(3)4/h10,13-16,21,26H,7-9,11-12H2,1-6H3/t21-/m0/s1	LWOGRFWTMAWXEC-NRFANRHFSA-N	326515	US9662327, Compound 212	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326515	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326515&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166691	384581469							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642404	CC(C)[C@@H]1CN(CCN1C(=O)c1ocnc1C)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H35N5O3/c1-15(2)21-12-30(8-9-31(21)25(32)23-17(5)28-14-33-23)24-19(11-27)18-10-26(6,7)34-13-20(18)22(29-24)16(3)4/h14-16,21H,8-10,12-13H2,1-7H3/t21-/m0/s1	DIYTZWXDTYTGLX-NRFANRHFSA-N	326516	US9662327, Compound 213	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326516	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326516&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283446	384581470							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642405	CC(C)[C@@H]1CN(CCN1C(=O)Cc1ccccn1)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C28H37N5O2/c1-18(2)24-16-32(11-12-33(24)25(34)13-20-9-7-8-10-30-20)27-22(15-29)21-14-28(5,6)35-17-23(21)26(31-27)19(3)4/h7-10,18-19,24H,11-14,16-17H2,1-6H3/t24-/m0/s1	YTSRKKDVVZMWJZ-DEOSSOPVSA-N	326517	US9662327, Compound 214	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326517	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326517&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283201	384581471							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642406	CC(C)[C@@H]1CN(CCN1C(=O)Cc1ccccc1F)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C29H37FN4O2/c1-18(2)25-16-33(11-12-34(25)26(35)13-20-9-7-8-10-24(20)30)28-22(15-31)21-14-29(5,6)36-17-23(21)27(32-28)19(3)4/h7-10,18-19,25H,11-14,16-17H2,1-6H3/t25-/m0/s1	FFISHOUYGBJPJP-VWLOTQADSA-N	326518	US9662327, Compound 215	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326518	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326518&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282948	384581472							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642407	COc1ccccc1CC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C30H40N4O3/c1-19(2)25-17-33(12-13-34(25)27(35)14-21-10-8-9-11-26(21)36-7)29-23(16-31)22-15-30(5,6)37-18-24(22)28(32-29)20(3)4/h8-11,19-20,25H,12-15,17-18H2,1-7H3/t25-/m0/s1	PHBVHZCEINJGNH-VWLOTQADSA-N	326519	US9662327, Compound 216	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326519	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326519&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283010	384581473							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642408	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)c2cnoc2C)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C24H31N5O3/c1-14(2)21-20-13-31-24(5,6)9-17(20)18(10-25)22(27-21)28-7-8-29(15(3)12-28)23(30)19-11-26-32-16(19)4/h11,14-15H,7-9,12-13H2,1-6H3/t15-/m1/s1	DUMWVXOARGYXOR-OAHLLOKOSA-N	326520	US9662327, Compound 217	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326520	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326520&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283248	384581474							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642409	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)Cc2ccccn2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C26H33N5O2/c1-17(2)24-22-16-33-26(4,5)13-20(22)21(14-27)25(29-24)30-10-11-31(18(3)15-30)23(32)12-19-8-6-7-9-28-19/h6-9,17-18H,10-13,15-16H2,1-5H3/t18-/m1/s1	UBCGZCCLKWTKSA-GOSISDBHSA-N	326521	US9662327, Compound 218	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326521	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326521&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283127	384581475							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642410	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)Cc2ccccc2F)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C27H33FN4O2/c1-17(2)25-22-16-34-27(4,5)13-20(22)21(14-29)26(30-25)31-10-11-32(18(3)15-31)24(33)12-19-8-6-7-9-23(19)28/h6-9,17-18H,10-13,15-16H2,1-5H3/t18-/m1/s1	BPOJHVTWZGFUDW-GOSISDBHSA-N	326522	US9662327, Compound 219	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326522	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326522&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283536	384581476							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642411	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)c2c(C)nc3ccccn23)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C28H34N6O2/c1-17(2)24-22-16-36-28(5,6)13-20(22)21(14-29)26(31-24)32-11-12-33(18(3)15-32)27(35)25-19(4)30-23-9-7-8-10-34(23)25/h7-10,17-18H,11-13,15-16H2,1-6H3/t18-/m1/s1	ORIWMVYOLUMYDN-GOSISDBHSA-N	326523	US9662327, Compound 220	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326523	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326523&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71477286	384581477							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642412	COc1cccc(CC(=O)N2CCN(C[C@H]2C)c2nc(C(C)C)c3COC(C)(C)Cc3c2C#N)c1	InChI=1S/C28H36N4O3/c1-18(2)26-24-17-35-28(4,5)14-22(24)23(15-29)27(30-26)31-10-11-32(19(3)16-31)25(33)13-20-8-7-9-21(12-20)34-6/h7-9,12,18-19H,10-11,13-14,16-17H2,1-6H3/t19-/m1/s1	GZSOZKICOKEMTJ-LJQANCHMSA-N	326524	US9662327, Compound 221	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326524	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326524&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282960	384581478							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642413	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)c2cnc3ccccn23)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C27H32N6O2/c1-17(2)24-21-16-35-27(4,5)12-19(21)20(13-28)25(30-24)31-10-11-32(18(3)15-31)26(34)22-14-29-23-8-6-7-9-33(22)23/h6-9,14,17-18H,10-12,15-16H2,1-5H3/t18-/m1/s1	MPTPQXPPRHCOPW-GOSISDBHSA-N	326525	US9662327, Compound 222	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326525	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326525&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283005	384581479							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642414	CC(C)c1nc(N2CCN([C@H](C2)c2ccccc2)C(=O)c2ccco2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C29H32N4O3/c1-19(2)26-23-18-36-29(3,4)15-21(23)22(16-30)27(31-26)32-12-13-33(28(34)25-11-8-14-35-25)24(17-32)20-9-6-5-7-10-20/h5-11,14,19,24H,12-13,15,17-18H2,1-4H3/t24-/m1/s1	SFVUOGOQXSSKCX-XMMPIXPASA-N	326526	US9662327, Compound 223	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326526	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326526&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282955	384581480							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642415	COc1ccccc1CC(=O)N1CCN(C[C@H]1C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C29H36N4O3/c1-20-18-32(13-14-33(20)27(34)16-22-10-6-7-11-26(22)35-2)29-24(17-30)23-12-15-36-19-25(23)28(31-29)21-8-4-3-5-9-21/h6-7,10-11,20-21H,3-5,8-9,12-16,18-19H2,1-2H3/t20-/m1/s1	HMGPIFYDIZGZEQ-HXUWFJFHSA-N	326527	US9662327, Compound 224	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326527	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326527&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119195	384581481							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642416	C[C@@H]1CN(CCN1C(=O)c1ocnc1C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C25H31N5O3/c1-16-13-29(9-10-30(16)25(31)23-17(2)27-15-33-23)24-20(12-26)19-8-11-32-14-21(19)22(28-24)18-6-4-3-5-7-18/h15-16,18H,3-11,13-14H2,1-2H3/t16-/m1/s1	LPNREDPVBDNOHD-MRXNPFEDSA-N	326528	US9662327, Compound 225	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326528	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326528&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282789	384581482							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642417	C[C@@H]1CN(CCN1C(=O)c1cocn1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C24H29N5O3/c1-16-12-28(8-9-29(16)24(30)21-14-32-15-26-21)23-19(11-25)18-7-10-31-13-20(18)22(27-23)17-5-3-2-4-6-17/h14-17H,2-10,12-13H2,1H3/t16-/m1/s1	OZVGGMWTZOQVMB-MRXNPFEDSA-N	326529	US9662327, Compound 226	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326529	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326529&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118627	384581483							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642418	C[C@@H]1CN(CCN1C(=O)c1cnc2ccccn12)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C28H32N6O2/c1-19-17-32(12-13-33(19)28(35)24-16-30-25-9-5-6-11-34(24)25)27-22(15-29)21-10-14-36-18-23(21)26(31-27)20-7-3-2-4-8-20/h5-6,9,11,16,19-20H,2-4,7-8,10,12-14,17-18H2,1H3/t19-/m1/s1	GBISPMUROKWYRF-LJQANCHMSA-N	326530	US9662327, Compound 227	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326530	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326530&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283016	384581484							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642419	CC(C)[C@@H]1CN(CCN1C(=O)Cc1ccccc1F)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C29H35FN4O2/c1-18(2)25-16-33(11-12-34(25)26(35)13-20-7-5-6-8-24(20)30)28-22(15-31)21-14-29(3,4)36-17-23(21)27(32-28)19-9-10-19/h5-8,18-19,25H,9-14,16-17H2,1-4H3/t25-/m0/s1	JOJACZLGRDBAQV-VWLOTQADSA-N	326531	US9662327, Compound 228	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326531	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326531&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295096	384581485							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642420	CC(C)[C@@H]1CN(CCN1C(=O)c1c(C)nc2ccccn12)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C30H36N6O2/c1-18(2)24-16-34(12-13-35(24)29(37)27-19(3)32-25-8-6-7-11-36(25)27)28-22(15-31)21-14-30(4,5)38-17-23(21)26(33-28)20-9-10-20/h6-8,11,18,20,24H,9-10,12-14,16-17H2,1-5H3/t24-/m0/s1	DIHDLPKBHUVWJW-DEOSSOPVSA-N	326532	US9662327, Compound 229	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326532	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326532&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166693	384581486							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642421	CC1Cc2c(CO1)c(nc(N1CCN([C@H](C)C1)C(=O)c1ccoc1C)c2C#N)C1CC1	InChI=1S/C24H28N4O3/c1-14-12-27(7-8-28(14)24(29)18-6-9-30-16(18)3)23-20(11-25)19-10-15(2)31-13-21(19)22(26-23)17-4-5-17/h6,9,14-15,17H,4-5,7-8,10,12-13H2,1-3H3/t14-,15?/m1/s1	KPDZOHLAAKLMSX-GICMACPYSA-N	326533	US9662327, Compound 230	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326533	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326533&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166692	384581487							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642422	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)Cc2cccs2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C25H32N4O2S/c1-16(2)23-21-15-31-25(4,5)12-19(21)20(13-26)24(27-23)28-8-9-29(17(3)14-28)22(30)11-18-7-6-10-32-18/h6-7,10,16-17H,8-9,11-12,14-15H2,1-5H3/t17-/m1/s1	NWBUGGOTZIREFX-QGZVFWFLSA-N	326461	US9662327, Compound 158::US9662327, Compound 231	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326461	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326461&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283288	384581415							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642423	CC(C)[C@@H]1CN(CCN1C(=O)c1cnn2cccnc12)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C28H33N7O2/c1-17(2)23-15-33(10-11-34(23)27(36)21-14-31-35-9-5-8-30-25(21)35)26-20(13-29)19-12-28(3,4)37-16-22(19)24(32-26)18-6-7-18/h5,8-9,14,17-18,23H,6-7,10-12,15-16H2,1-4H3/t23-/m0/s1	MMXVYIWZEXIVJB-QHCPKHFHSA-N	326535	US9662327, Compound 232	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326535	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326535&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71477287	384581488							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642424	COc1cccc(CC(=O)N2CCN(C[C@H]2C(C)C)c2nc(C(C)C)c3COC(C)(C)Cc3c2C#N)c1	InChI=1S/C30H40N4O3/c1-19(2)26-17-33(11-12-34(26)27(35)14-21-9-8-10-22(13-21)36-7)29-24(16-31)23-15-30(5,6)37-18-25(23)28(32-29)20(3)4/h8-10,13,19-20,26H,11-12,14-15,17-18H2,1-7H3/t26-/m0/s1	MZHOLZUTLWQHDR-SANMLTNESA-N	326536	US9662327, Compound 233	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326536	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326536&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283122	384581489							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642425	CC(C)[C@@H]1CN(CCN1C(=O)Cc1cccc(F)c1)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C29H37FN4O2/c1-18(2)25-16-33(10-11-34(25)26(35)13-20-8-7-9-21(30)12-20)28-23(15-31)22-14-29(5,6)36-17-24(22)27(32-28)19(3)4/h7-9,12,18-19,25H,10-11,13-14,16-17H2,1-6H3/t25-/m0/s1	HKFGRSTVNZBVAG-VWLOTQADSA-N	326537	US9662327, Compound 234	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326537	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326537&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282934	384581490							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642426	CC[C@@H]1CN(CCN1C(=O)c1ccoc1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H30N4O3/c1-4-18-13-28(8-9-29(18)24(30)17-7-10-31-14-17)23-20(12-26)19-11-25(2,3)32-15-21(19)22(27-23)16-5-6-16/h7,10,14,16,18H,4-6,8-9,11,13,15H2,1-3H3/t18-/m1/s1	NKDWQLLWXYJIJI-GOSISDBHSA-N	326538	US9662327, Compound 235	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326538	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326538&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295100	384581491							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642427	CC[C@@H]1CN(CCN1C(=O)Cc1cccs1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H32N4O2S/c1-4-18-15-29(9-10-30(18)23(31)12-19-6-5-11-33-19)25-21(14-27)20-13-26(2,3)32-16-22(20)24(28-25)17-7-8-17/h5-6,11,17-18H,4,7-10,12-13,15-16H2,1-3H3/t18-/m1/s1	ZISPCJRKYVWBAG-GOSISDBHSA-N	326539	US9662327, Compound 236	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326539	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326539&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295101	384581492							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642428	CC[C@@H]1CN(CCN1C(=O)c1ccoc1C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H32N4O3/c1-5-18-14-29(9-10-30(18)25(31)19-8-11-32-16(19)2)24-21(13-27)20-12-26(3,4)33-15-22(20)23(28-24)17-6-7-17/h8,11,17-18H,5-7,9-10,12,14-15H2,1-4H3/t18-/m1/s1	CFMSTPVBQGWHBW-GOSISDBHSA-N	326540	US9662327, Compound 237	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326540	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326540&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282757	384581493							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642429	C[C@@H]1CN(CCN1C(=O)Cc1ccccn1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C27H33N5O2/c1-19-17-31(12-13-32(19)25(33)15-21-9-5-6-11-29-21)27-23(16-28)22-10-14-34-18-24(22)26(30-27)20-7-3-2-4-8-20/h5-6,9,11,19-20H,2-4,7-8,10,12-15,17-18H2,1H3/t19-/m1/s1	ARONNGMRHRNPON-LJQANCHMSA-N	326541	US9662327, Compound 238	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326541	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326541&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283111	384581494							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642430	C[C@@H]1CN(CCN1C(=O)c1cscn1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C24H29N5O2S/c1-16-12-28(8-9-29(16)24(30)21-14-32-15-26-21)23-19(11-25)18-7-10-31-13-20(18)22(27-23)17-5-3-2-4-6-17/h14-17H,2-10,12-13H2,1H3/t16-/m1/s1	XLZHFPFDDYNAIJ-MRXNPFEDSA-N	326542	US9662327, Compound 239	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326542	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326542&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282581	384581495							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642431	COCCC(=O)N1CCN(C[C@H]1C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C24H34N4O3/c1-17-15-27(10-11-28(17)22(29)9-12-30-2)24-20(14-25)19-8-13-31-16-21(19)23(26-24)18-6-4-3-5-7-18/h17-18H,3-13,15-16H2,1-2H3/t17-/m1/s1	SGNYFOAZICJJQM-QGZVFWFLSA-N	326543	US9662327, Compound 240	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326543	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326543&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119283	384581496							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642432	C[C@@H]1CN(CCN1C(=O)c1cccs1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C25H30N4O2S/c1-17-15-28(10-11-29(17)25(30)22-8-5-13-32-22)24-20(14-26)19-9-12-31-16-21(19)23(27-24)18-6-3-2-4-7-18/h5,8,13,17-18H,2-4,6-7,9-12,15-16H2,1H3/t17-/m1/s1	YRIHEAFABIBYNQ-QGZVFWFLSA-N	326544	US9662327, Compound 241	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326544	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326544&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283134	384581497							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642433	C[C@@H]1CN(CCN1C(=O)c1ccsc1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C25H30N4O2S/c1-17-14-28(9-10-29(17)25(30)19-8-12-32-16-19)24-21(13-26)20-7-11-31-15-22(20)23(27-24)18-5-3-2-4-6-18/h8,12,16-18H,2-7,9-11,14-15H2,1H3/t17-/m1/s1	PKECZNDKHHIDEV-QGZVFWFLSA-N	326545	US9662327, Compound 242	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326545	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326545&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283000	384581498							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642434	C[C@@H]1CN(CCN1C(=O)c1csc2ccccc12)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C29H32N4O2S/c1-19-16-32(12-13-33(19)29(34)25-18-36-26-10-6-5-9-22(25)26)28-23(15-30)21-11-14-35-17-24(21)27(31-28)20-7-3-2-4-8-20/h5-6,9-10,18-20H,2-4,7-8,11-14,16-17H2,1H3/t19-/m1/s1	PKFYMBNKTFOKBE-LJQANCHMSA-N	326546	US9662327, Compound 243	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326546	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326546&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71477288	384581499							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642435	C[C@@H]1CN(CCN1C(=O)c1cc(C)oc1C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H32N4O3/c1-15-13-29(8-9-30(15)25(31)19-10-16(2)33-17(19)3)24-21(12-27)20-11-26(4,5)32-14-22(20)23(28-24)18-6-7-18/h10,15,18H,6-9,11,13-14H2,1-5H3/t15-/m1/s1	OAABQDDDOKVNTK-OAHLLOKOSA-N	326547	US9662327, Compound 244	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326547	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326547&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295104	384581500							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642436	CC(C)[C@@H]1CN(CCN1C(=O)c1cncc(C)c1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C28H35N5O2/c1-17(2)24-15-32(8-9-33(24)27(34)20-10-18(3)13-30-14-20)26-22(12-29)21-11-28(4,5)35-16-23(21)25(31-26)19-6-7-19/h10,13-14,17,19,24H,6-9,11,15-16H2,1-5H3/t24-/m0/s1	DGUQZUITQXNMPA-DEOSSOPVSA-N	326548	US9662327, Compound 245	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326548	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326548&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283263	384581501							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642437	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)c2cccs2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C24H30N4O2S/c1-15(2)21-19-14-30-24(4,5)11-17(19)18(12-25)22(26-21)27-8-9-28(16(3)13-27)23(29)20-7-6-10-31-20/h6-7,10,15-16H,8-9,11,13-14H2,1-5H3/t16-/m1/s1	CVTPWUXBTMWGQC-MRXNPFEDSA-N	326549	US9662327, Compound 246	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326549	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326549&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282936	384581502							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642438	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)c2csc3ccccc23)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C28H32N4O2S/c1-17(2)25-22-15-34-28(4,5)12-20(22)21(13-29)26(30-25)31-10-11-32(18(3)14-31)27(33)23-16-35-24-9-7-6-8-19(23)24/h6-9,16-18H,10-12,14-15H2,1-5H3/t18-/m1/s1	JTTBGZDYSKCANN-GOSISDBHSA-N	326550	US9662327, Compound 247	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326550	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326550&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282922	384581503							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642439	CC(C)[C@@H]1CN(CCN1C(=O)Cc1cccnc1)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C28H37N5O2/c1-18(2)24-16-32(10-11-33(24)25(34)12-20-8-7-9-30-15-20)27-22(14-29)21-13-28(5,6)35-17-23(21)26(31-27)19(3)4/h7-9,15,18-19,24H,10-13,16-17H2,1-6H3/t24-/m0/s1	FRLKPBHZEBMCNN-DEOSSOPVSA-N	326551	US9662327, Compound 248::US9662327, Compound 250	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326551	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326551&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282996	384581504							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642440	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)c2cccnc2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C25H31N5O2/c1-16(2)22-21-15-32-25(4,5)11-19(21)20(12-26)23(28-22)29-9-10-30(17(3)14-29)24(31)18-7-6-8-27-13-18/h6-8,13,16-17H,9-11,14-15H2,1-5H3/t17-/m1/s1	NIMCRCFPCSQSJG-QGZVFWFLSA-N	326552	US9662327, Compound 249	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326552	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326552&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282932	384581505							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642441	CC(C)[C@@H]1CN(CCN1C(=O)Cc1cccnc1)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C28H37N5O2/c1-18(2)24-16-32(10-11-33(24)25(34)12-20-8-7-9-30-15-20)27-22(14-29)21-13-28(5,6)35-17-23(21)26(31-27)19(3)4/h7-9,15,18-19,24H,10-13,16-17H2,1-6H3/t24-/m0/s1	FRLKPBHZEBMCNN-DEOSSOPVSA-N	326551	US9662327, Compound 248::US9662327, Compound 250	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326551	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326551&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282996	384581504							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642442	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)c2ccsc2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C24H30N4O2S/c1-15(2)21-20-13-30-24(4,5)10-18(20)19(11-25)22(26-21)27-7-8-28(16(3)12-27)23(29)17-6-9-31-14-17/h6,9,14-16H,7-8,10,12-13H2,1-5H3/t16-/m1/s1	YKCRJAREYKIRJD-MRXNPFEDSA-N	326554	US9662327, Compound 251	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326554	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326554&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282653	384581506							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642443	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)c2cscn2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C23H29N5O2S/c1-14(2)20-18-11-30-23(4,5)8-16(18)17(9-24)21(26-20)27-6-7-28(15(3)10-27)22(29)19-12-31-13-25-19/h12-15H,6-8,10-11H2,1-5H3/t15-/m1/s1	UIMPWXYVUGWLJW-OAHLLOKOSA-N	326555	US9662327, Compound 252	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326555	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326555&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283097	384581507							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642444	CC(C)c1nc(N2CCN([C@H](C)C2)C(=O)C2CCOC2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C24H34N4O3/c1-15(2)21-20-14-31-24(4,5)10-18(20)19(11-25)22(26-21)27-7-8-28(16(3)12-27)23(29)17-6-9-30-13-17/h15-17H,6-10,12-14H2,1-5H3/t16-,17?/m1/s1	IZIDUFGTTHRJEW-TZHYSIJRSA-N	326556	US9662327, Compound 253	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326556	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326556&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282767	384581508							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642445	COc1cccc(CC(=O)N2CCN(C[C@H]2C(C)C)c2nc(C3CC3)c3COC(C)(C)Cc3c2C#N)c1	InChI=1S/C30H38N4O3/c1-19(2)26-17-33(11-12-34(26)27(35)14-20-7-6-8-22(13-20)36-5)29-24(16-31)23-15-30(3,4)37-18-25(23)28(32-29)21-9-10-21/h6-8,13,19,21,26H,9-12,14-15,17-18H2,1-5H3/t26-/m0/s1	RPCZZNHLVHMUOT-SANMLTNESA-N	326557	US9662327, Compound 254	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326557	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326557&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295107	384581509							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642446	CC(C)[C@@H]1CN(CCN1C(=O)c1ccsc1)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H34N4O2S/c1-16(2)22-13-29(8-9-30(22)25(31)18-7-10-33-15-18)24-20(12-27)19-11-26(5,6)32-14-21(19)23(28-24)17(3)4/h7,10,15-17,22H,8-9,11,13-14H2,1-6H3/t22-/m0/s1	YCPKDNKLYYVYSC-QFIPXVFZSA-N	326558	US9662327, Compound 255	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326558	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326558&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295108	384581510							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642447	CC(C)c1nc(N2CCN([C@@H](C2)c2ccccc2)C(=O)c2ccoc2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C29H32N4O3/c1-19(2)26-24-18-36-29(3,4)14-22(24)23(15-30)27(31-26)32-11-12-33(28(34)21-10-13-35-17-21)25(16-32)20-8-6-5-7-9-20/h5-10,13,17,19,25H,11-12,14,16,18H2,1-4H3/t25-/m0/s1	VYOCJCUGCJATIM-VWLOTQADSA-N	326559	US9662327, Compound 256	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326559	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326559&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282672	384581511							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642448	CC(C)c1nc(N2CCN([C@H](C2)c2ccccc2)C(=O)c2ccoc2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C29H32N4O3/c1-19(2)26-24-18-36-29(3,4)14-22(24)23(15-30)27(31-26)32-11-12-33(28(34)21-10-13-35-17-21)25(16-32)20-8-6-5-7-9-20/h5-10,13,17,19,25H,11-12,14,16,18H2,1-4H3/t25-/m1/s1	VYOCJCUGCJATIM-RUZDIDTESA-N	326560	US9662327, Compound 257	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326560	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326560&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283102	384581512							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642449	CCOC(=O)C1CN(CCN1C(=O)c1ccoc1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C27H32N4O5/c1-2-36-27(33)23-15-30(10-11-31(23)26(32)19-8-12-34-16-19)25-21(14-28)20-9-13-35-17-22(20)24(29-25)18-6-4-3-5-7-18/h8,12,16,18,23H,2-7,9-11,13,15,17H2,1H3	NCKVMHWBTUSGSJ-UHFFFAOYSA-N	326561	US9662327, Compound 258	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326561	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326561&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282941	384581513							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642450	CCOC(=O)C1CN(CCN1C(=O)c1ccoc1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H30N4O5/c1-4-34-25(32)21-13-29(8-9-30(21)24(31)17-7-10-33-14-17)23-19(12-27)18-11-26(2,3)35-15-20(18)22(28-23)16-5-6-16/h7,10,14,16,21H,4-6,8-9,11,13,15H2,1-3H3	SXFZOQHHHQVESE-UHFFFAOYSA-N	326562	US9662327, Compound 259	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326562	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326562&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118944	384581514							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642451	C[C@@H]1CN(CCN1C(=O)Cc1cccnc1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C27H33N5O2/c1-19-17-31(11-12-32(19)25(33)14-20-6-5-10-29-16-20)27-23(15-28)22-9-13-34-18-24(22)26(30-27)21-7-3-2-4-8-21/h5-6,10,16,19,21H,2-4,7-9,11-14,17-18H2,1H3/t19-/m1/s1	LOMXKDRQBNLFJV-LJQANCHMSA-N	326563	US9662327, Compound 260	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326563	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326563&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282766	384581515							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642452	C[C@@H]1CN(CCN1C(=O)c1cnn2cccnc12)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C27H31N7O2/c1-18-16-32(11-12-33(18)27(35)22-15-30-34-10-5-9-29-25(22)34)26-21(14-28)20-8-13-36-17-23(20)24(31-26)19-6-3-2-4-7-19/h5,9-10,15,18-19H,2-4,6-8,11-13,16-17H2,1H3/t18-/m1/s1	GBLCEBUNEXHMQM-GOSISDBHSA-N	326564	US9662327, Compound 261	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326564	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326564&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119567	384581516							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642453	C[C@@H]1CN(CCN1C(=O)c1nccn1C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C25H32N6O2/c1-17-15-30(11-12-31(17)25(32)24-27-9-10-29(24)2)23-20(14-26)19-8-13-33-16-21(19)22(28-23)18-6-4-3-5-7-18/h9-10,17-18H,3-8,11-13,15-16H2,1-2H3/t17-/m1/s1	BPKHFTIXYCDCRY-QGZVFWFLSA-N	326565	US9662327, Compound 262	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326565	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326565&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283418	384581517							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642454	C[C@@H]1CN(CCN1C(=O)C1CCOC1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C25H34N4O3/c1-17-14-28(9-10-29(17)25(30)19-7-11-31-15-19)24-21(13-26)20-8-12-32-16-22(20)23(27-24)18-5-3-2-4-6-18/h17-19H,2-12,14-16H2,1H3/t17-,19?/m1/s1	UFCRRVMHEREEJR-DUSLRRAJSA-N	326566	US9662327, Compound 263	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326566	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326566&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119158	384581518							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642455	CSCCC(=O)N1CCN(C[C@H]1C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C24H34N4O2S/c1-17-15-27(10-11-28(17)22(29)9-13-31-2)24-20(14-25)19-8-12-30-16-21(19)23(26-24)18-6-4-3-5-7-18/h17-18H,3-13,15-16H2,1-2H3/t17-/m1/s1	WEIGUSDGSMMADJ-QGZVFWFLSA-N	326567	US9662327, Compound 264	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326567	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326567&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118428	384581519							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642456	CC(C)[C@@H]1CN(CCN1C(=O)Cc1cccnc1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C28H35N5O2/c1-18(2)24-16-32(10-11-33(24)25(34)12-19-6-5-9-30-15-19)27-22(14-29)21-13-28(3,4)35-17-23(21)26(31-27)20-7-8-20/h5-6,9,15,18,20,24H,7-8,10-13,16-17H2,1-4H3/t24-/m0/s1	ATCMOSAJAAALAE-DEOSSOPVSA-N	326568	US9662327, Compound 265	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326568	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326568&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295110	384581520							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642457	CC(C)[C@@H]1CN(CCN1C(=O)C1CCOC1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H36N4O3/c1-16(2)22-13-29(8-9-30(22)25(31)18-7-10-32-14-18)24-20(12-27)19-11-26(3,4)33-15-21(19)23(28-24)17-5-6-17/h16-18,22H,5-11,13-15H2,1-4H3/t18?,22-/m0/s1	BPOUBVZSOYDWQT-YSYXNDDBSA-N	326569	US9662327, Compound 266	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326569	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326569&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295111	384581521							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642458	CSCCC(=O)N1CCN(C[C@H]1C)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C23H34N4O2S/c1-15(2)21-19-14-29-23(4,5)11-17(19)18(12-24)22(25-21)26-8-9-27(16(3)13-26)20(28)7-10-30-6/h15-16H,7-11,13-14H2,1-6H3/t16-/m1/s1	BAQOKPILIVQMEQ-MRXNPFEDSA-N	326570	US9662327, Compound 267	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326570	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326570&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283174	384581522							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642459	COCCC(=O)N1CCN(C[C@H]1C)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C23H34N4O3/c1-15(2)21-19-14-30-23(4,5)11-17(19)18(12-24)22(25-21)26-8-9-27(16(3)13-26)20(28)7-10-29-6/h15-16H,7-11,13-14H2,1-6H3/t16-/m1/s1	RPEUKBQNTVHXBC-MRXNPFEDSA-N	326571	US9662327, Compound 268	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326571	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326571&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283438	384581523							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642460	CSCCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C25H38N4O2S/c1-16(2)21-14-28(9-10-29(21)22(30)8-11-32-5)24-19(13-26)18-12-25(3,4)31-15-20(18)23(27-24)17-6-7-17/h13,16-17,21,26H,6-12,14-15H2,1-5H3/t21-/m0/s1	YTUWRRGBVHVHNJ-NRFANRHFSA-N	326572	US9662327, Compound 269	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326572	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326572&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295112	384581524							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642461	COCCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C(C)C)c2COC(C)(C)Cc2c1C=N	InChI=1S/C25H40N4O3/c1-16(2)21-14-28(9-10-29(21)22(30)8-11-31-7)24-19(13-26)18-12-25(5,6)32-15-20(18)23(27-24)17(3)4/h13,16-17,21,26H,8-12,14-15H2,1-7H3/t21-/m0/s1	JNYHYIDUWURPSP-NRFANRHFSA-N	326573	US9662327, Compound 270	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326573	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326573&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295113	384581525							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642462	CC(C)[C@@H]1CN(CCN1C(=O)c1cccnc1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H33N5O2/c1-17(2)23-15-31(10-11-32(23)26(33)19-6-5-9-29-14-19)25-21(13-28)20-12-27(3,4)34-16-22(20)24(30-25)18-7-8-18/h5-6,9,14,17-18,23H,7-8,10-12,15-16H2,1-4H3/t23-/m0/s1	GZAFOXPFTNDZGV-QHCPKHFHSA-N	326574	US9662327, Compound 271	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326574	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326574&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295114	384581526							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642463	CC1(C)Cc2c(CO1)c(nc(N1CCN([C@@H](C1)c1ccccc1)C(=O)c1ccco1)c2C#N)C1CC1	InChI=1S/C29H30N4O3/c1-29(2)15-21-22(16-30)27(31-26(20-10-11-20)23(21)18-36-29)32-12-13-33(28(34)25-9-6-14-35-25)24(17-32)19-7-4-3-5-8-19/h3-9,14,20,24H,10-13,15,17-18H2,1-2H3/t24-/m0/s1	PETTYHBOXLTJQF-DEOSSOPVSA-N	326575	US9662327, Compound 272	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326575	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326575&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166694	384581527							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642464	CC1(C)Cc2c(CO1)c(nc(N1CCN([C@H](C1)c1ccccc1)C(=O)c1ccco1)c2C#N)C1CC1	InChI=1S/C29H30N4O3/c1-29(2)15-21-22(16-30)27(31-26(20-10-11-20)23(21)18-36-29)32-12-13-33(28(34)25-9-6-14-35-25)24(17-32)19-7-4-3-5-8-19/h3-9,14,20,24H,10-13,15,17-18H2,1-2H3/t24-/m1/s1	PETTYHBOXLTJQF-XMMPIXPASA-N	326576	US9662327, Compound 273	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326576	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326576&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166695	384581528							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642465	CC1(C)Cc2c(CO1)c(nc(N1CCN([C@@H](C1)c1ccccc1)C(=O)c1ccoc1)c2C#N)C1CC1	InChI=1S/C29H30N4O3/c1-29(2)14-22-23(15-30)27(31-26(20-8-9-20)24(22)18-36-29)32-11-12-33(28(34)21-10-13-35-17-21)25(16-32)19-6-4-3-5-7-19/h3-7,10,13,17,20,25H,8-9,11-12,14,16,18H2,1-2H3/t25-/m0/s1	LQRQGQQFPCRRAA-VWLOTQADSA-N	326577	US9662327, Compound 274	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326577	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326577&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282992	384581529							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642466	CC1(C)Cc2c(CO1)c(nc(N1CCN([C@H](C1)c1ccccc1)C(=O)c1ccoc1)c2C#N)C1CC1	InChI=1S/C29H30N4O3/c1-29(2)14-22-23(15-30)27(31-26(20-8-9-20)24(22)18-36-29)32-11-12-33(28(34)21-10-13-35-17-21)25(16-32)19-6-4-3-5-7-19/h3-7,10,13,17,20,25H,8-9,11-12,14,16,18H2,1-2H3/t25-/m1/s1	LQRQGQQFPCRRAA-RUZDIDTESA-N	326578	US9662327, Compound 275	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326578	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326578&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295118	384581530							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642467	CCOC(=O)C1CN(CCN1C(=O)c1ccoc1)c1nc(C(C)C)c2COC(C)(C)Cc2c1C=N	InChI=1S/C26H34N4O5/c1-6-34-25(32)21-13-29(8-9-30(21)24(31)17-7-10-33-14-17)23-19(12-27)18-11-26(4,5)35-15-20(18)22(28-23)16(2)3/h7,10,12,14,16,21,27H,6,8-9,11,13,15H2,1-5H3	ASYUYUQDGWWKAR-UHFFFAOYSA-N	326579	US9662327, Compound 276	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326579	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326579&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295119	384581531							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642468	CCOC(=O)C1CN(CCN1C(=O)c1ccoc1C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C28H34N4O5/c1-3-36-28(34)24-16-31(11-12-32(24)27(33)20-10-14-37-18(20)2)26-22(15-29)21-9-13-35-17-23(21)25(30-26)19-7-5-4-6-8-19/h10,14,19,24H,3-9,11-13,16-17H2,1-2H3	CFGAFSJTHVIDFC-UHFFFAOYSA-N	326580	US9662327, Compound 277	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326580	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326580&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118979	384581532							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642469	CCOC(=O)C1CN(CCN1C(=O)CCOC)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C26H36N4O5/c1-3-35-26(32)22-16-29(11-12-30(22)23(31)10-13-33-2)25-20(15-27)19-9-14-34-17-21(19)24(28-25)18-7-5-4-6-8-18/h18,22H,3-14,16-17H2,1-2H3	GKOKOCVBQDQFCG-UHFFFAOYSA-N	326581	US9662327, Compound 278	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326581	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326581&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119418	384581533							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642470	C[C@@H]1CN(CCN1C(=O)Nc1ccccc1C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C28H35N5O2/c1-19-8-6-7-11-25(19)30-28(34)33-14-13-32(17-20(33)2)27-23(16-29)22-12-15-35-18-24(22)26(31-27)21-9-4-3-5-10-21/h6-8,11,20-21H,3-5,9-10,12-15,17-18H2,1-2H3,(H,30,34)/t20-/m1/s1	OJXHHIZGAQDQHB-HXUWFJFHSA-N	326582	US9662327, Compound 279	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326582	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326582&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282741	384581534							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642471	C[C@@H]1CN(CCN1C(=O)Nc1ccc(C)cc1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C28H35N5O2/c1-19-8-10-22(11-9-19)30-28(34)33-14-13-32(17-20(33)2)27-24(16-29)23-12-15-35-18-25(23)26(31-27)21-6-4-3-5-7-21/h8-11,20-21H,3-7,12-15,17-18H2,1-2H3,(H,30,34)/t20-/m1/s1	SMUQHAPAJRCEJQ-HXUWFJFHSA-N	326583	US9662327, Compound 280	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326583	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326583&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119245	384581535							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642472	C[C@@H]1CN(CCN1C(=O)Nc1ccc(F)cc1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C27H32FN5O2/c1-18-16-32(12-13-33(18)27(34)30-21-9-7-20(28)8-10-21)26-23(15-29)22-11-14-35-17-24(22)25(31-26)19-5-3-2-4-6-19/h7-10,18-19H,2-6,11-14,16-17H2,1H3,(H,30,34)/t18-/m1/s1	CMYZTXYQZAQWMU-GOSISDBHSA-N	326584	US9662327, Compound 281	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326584	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326584&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283031	384581536							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642473	CCOc1ccc(NC(O)N2CCN(C[C@H]2C(C)C)c2nc(C3CC3)c3COC(C)(C)Cc3c2C#N)cc1	InChI=1S/C30H41N5O3/c1-6-37-22-11-9-21(10-12-22)32-29(36)35-14-13-34(17-26(35)19(2)3)28-24(16-31)23-15-30(4,5)38-18-25(23)27(33-28)20-7-8-20/h9-12,19-20,26,29,32,36H,6-8,13-15,17-18H2,1-5H3/t26-,29?/m0/s1	IWYIZIZOWFRFLR-QUWDGAPNSA-N	326585	US9662327, Compound 282	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326585	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326585&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295121	384581537							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642474	CC(C)[C@@H]1CN(CCN1C(=O)Nc1ccc(F)cc1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C28H34FN5O2/c1-17(2)24-15-33(11-12-34(24)27(35)31-20-9-7-19(29)8-10-20)26-22(14-30)21-13-28(3,4)36-16-23(21)25(32-26)18-5-6-18/h7-10,17-18,24H,5-6,11-13,15-16H2,1-4H3,(H,31,35)/t24-/m0/s1	SJQNNNUYJVVGRP-DEOSSOPVSA-N	326586	US9662327, Compound 283	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326586	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326586&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295122	384581538							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642475	CC(C)[C@@H]1CN(CCN1S(=O)(=O)c1cccs1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H32N4O3S2/c1-16(2)21-14-28(9-10-29(21)34(30,31)22-6-5-11-33-22)24-19(13-26)18-12-25(3,4)32-15-20(18)23(27-24)17-7-8-17/h5-6,11,16-17,21H,7-10,12,14-15H2,1-4H3/t21-/m0/s1	RDVAXYQIBMCOMP-NRFANRHFSA-N	326587	US9662327, Compound 284	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326587	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326587&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283138	384581539							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642476	CC(C)[C@@H]1CN(CCN1S(=O)(=O)c1ccc(Cl)s1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C25H33ClN4O3S2/c1-15(2)20-13-29(9-10-30(20)35(31,32)22-8-7-21(26)34-22)24-18(12-27)17-11-25(3,4)33-14-19(17)23(28-24)16-5-6-16/h7-8,12,15-16,20,27H,5-6,9-11,13-14H2,1-4H3/t20-/m0/s1	BYZKMVAPPXCLDT-FQEVSTJZSA-N	326588	US9662327, Compound 285	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326588	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326588&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295124	384581540							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642477	CC(C)[C@@H]1CN(CCN1C(=O)NCCc1ccccc1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C30H39N5O2/c1-20(2)26-18-34(14-15-35(26)29(36)32-13-12-21-8-6-5-7-9-21)28-24(17-31)23-16-30(3,4)37-19-25(23)27(33-28)22-10-11-22/h5-9,20,22,26H,10-16,18-19H2,1-4H3,(H,32,36)/t26-/m0/s1	FJDMDNIXEZEAMV-SANMLTNESA-N	326589	US9662327, Compound 286	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326589	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326589&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295123	384581541							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642478	CC(C)NC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H37N5O2/c1-15(2)21-13-29(9-10-30(21)24(31)27-16(3)4)23-19(12-26)18-11-25(5,6)32-14-20(18)22(28-23)17-7-8-17/h15-17,21H,7-11,13-14H2,1-6H3,(H,27,31)/t21-/m0/s1	ATEJOHACLGJDMH-NRFANRHFSA-N	326590	US9662327, Compound 287	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326590	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326590&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295125	384581542							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642479	CC(C)[C@@H]1CN(CCN1C(=O)c1ccoc1)c1nc(C2CCC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C27H36N4O3/c1-17(2)23-14-30(9-10-31(23)26(32)19-8-11-33-15-19)25-21(13-28)20-12-27(3,4)34-16-22(20)24(29-25)18-6-5-7-18/h8,11,13,15,17-18,23,28H,5-7,9-10,12,14,16H2,1-4H3/t23-/m0/s1	CJHFNRWSSRJZID-QHCPKHFHSA-N	326591	US9662327, Compound 288	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326591	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326591&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295126	384581543							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642480	CC(C)[C@@H]1CN(CCN1C(=O)Cc1cccs1)c1nc(C2CCC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C28H36N4O2S/c1-18(2)24-16-31(10-11-32(24)25(33)13-20-9-6-12-35-20)27-22(15-29)21-14-28(3,4)34-17-23(21)26(30-27)19-7-5-8-19/h6,9,12,18-19,24H,5,7-8,10-11,13-14,16-17H2,1-4H3/t24-/m0/s1	AIBRFJAQXPYVRB-DEOSSOPVSA-N	326592	US9662327, Compound 289	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326592	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326592&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282864	384581544							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642481	CC[C@@H]1CN(CCN1C(=O)Cc1ccccn1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H33N5O2/c1-4-20-16-31(11-12-32(20)24(33)13-19-7-5-6-10-29-19)26-22(15-28)21-14-27(2,3)34-17-23(21)25(30-26)18-8-9-18/h5-7,10,18,20H,4,8-9,11-14,16-17H2,1-3H3/t20-/m1/s1	JKQZRZIXLYHFPY-HXUWFJFHSA-N	326593	US9662327, Compound 290	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326593	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326593&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295127	384581545							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642482	CC[C@@H]1CN(CCN1C(O)c1cocn1)c1nc(C2CC2)c(CO)c(CC(C)C)c1C#N	InChI=1S/C24H33N5O3/c1-4-17-11-28(7-8-29(17)24(31)21-13-32-14-26-21)23-19(10-25)18(9-15(2)3)20(12-30)22(27-23)16-5-6-16/h13-17,24,30-31H,4-9,11-12H2,1-3H3/t17-,24?/m1/s1	DFHSZRDLACWCIC-BPNWFJGMSA-N	326594	US9662327, Compound 291	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326594	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326594&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295128	384581546							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642483	CC[C@@H]1CN(CCN1C(O)c1ccsc1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H32N4O2S/c1-4-18-13-28(8-9-29(18)24(30)17-7-10-32-15-17)23-20(12-26)19-11-25(2,3)31-14-21(19)22(27-23)16-5-6-16/h7,10,15-16,18,24,30H,4-6,8-9,11,13-14H2,1-3H3/t18-,24?/m1/s1	FNKZXHKIRYRMSH-QFADGXAASA-N	326595	US9662327, Compound 292	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326595	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326595&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166696	384581547							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642484	CC[C@@H]1CN(CCN1C(=O)c1cscn1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H29N5O2S/c1-4-16-11-28(7-8-29(16)23(30)20-13-32-14-26-20)22-18(10-25)17-9-24(2,3)31-12-19(17)21(27-22)15-5-6-15/h13-16H,4-9,11-12H2,1-3H3/t16-/m1/s1	FSZQBKPLELMEMY-MRXNPFEDSA-N	326596	US9662327, Compound 293	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326596	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326596&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295130	384581548							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642485	CC[C@@H]1CN(CCN1C(=O)Cc1cccnc1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H33N5O2/c1-4-20-16-31(10-11-32(20)24(33)12-18-6-5-9-29-15-18)26-22(14-28)21-13-27(2,3)34-17-23(21)25(30-26)19-7-8-19/h5-6,9,15,19-20H,4,7-8,10-13,16-17H2,1-3H3/t20-/m1/s1	IWISMVZUGBLXDK-HXUWFJFHSA-N	326597	US9662327, Compound 294	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326597	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326597&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295131	384581549							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642486	CC[C@@H]1CN(CCN1C(=O)Cc1ccccc1OC)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C29H36N4O3/c1-5-21-17-32(12-13-33(21)26(34)14-20-8-6-7-9-25(20)35-4)28-23(16-30)22-15-29(2,3)36-18-24(22)27(31-28)19-10-11-19/h6-9,19,21H,5,10-15,17-18H2,1-4H3/t21-/m1/s1	CMKTYKVTAFQJJV-OAQYLSRUSA-N	326598	US9662327, Compound 295	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326598	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326598&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295132	384581550							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642487	CC[C@@H]1CN(CCN1C(=O)Cc1cccc(OC)c1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C29H36N4O3/c1-5-21-17-32(11-12-33(21)26(34)14-19-7-6-8-22(13-19)35-4)28-24(16-30)23-15-29(2,3)36-18-25(23)27(31-28)20-9-10-20/h6-8,13,20-21H,5,9-12,14-15,17-18H2,1-4H3/t21-/m1/s1	YJSBKCPJYBFRGG-OAQYLSRUSA-N	326599	US9662327, Compound 296	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326599	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326599&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295134	384581551							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642488	CC[C@@H]1CN(CCN1C(=O)CCOC)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H34N4O3/c1-5-17-14-27(9-10-28(17)21(29)8-11-30-4)23-19(13-25)18-12-24(2,3)31-15-20(18)22(26-23)16-6-7-16/h16-17H,5-12,14-15H2,1-4H3/t17-/m1/s1	FAPJZSFBNCOPCN-QGZVFWFLSA-N	326600	US9662327, Compound 297	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326600	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326600&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283285	384581552							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642489	CCOC(=O)C1CN(CCN1C(=O)c1ccco1)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H32N4O5/c1-6-33-25(32)20-14-29(9-10-30(20)24(31)21-8-7-11-34-21)23-18(13-27)17-12-26(4,5)35-15-19(17)22(28-23)16(2)3/h7-8,11,16,20H,6,9-10,12,14-15H2,1-5H3	BKOFGXTVIXIKHW-UHFFFAOYSA-N	326601	US9662327, Compound 298	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326601	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326601&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282811	384581553							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642490	COc1ccc(NC(=O)N2CCN(C[C@H]2C)c2nc(C3CCCCC3)c3COCCc3c2C#N)cc1	InChI=1S/C28H35N5O3/c1-19-17-32(13-14-33(19)28(34)30-21-8-10-22(35-2)11-9-21)27-24(16-29)23-12-15-36-18-25(23)26(31-27)20-6-4-3-5-7-20/h8-11,19-20H,3-7,12-15,17-18H2,1-2H3,(H,30,34)/t19-/m1/s1	MIMZQWFXHQPOKF-LJQANCHMSA-N	326602	US9662327, Compound 299	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326602	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326602&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282872	384581554							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642491	C[C@@H]1CN(CCN1C(=O)Nc1ccccc1F)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C27H32FN5O2/c1-18-16-32(12-13-33(18)27(34)30-24-10-6-5-9-23(24)28)26-21(15-29)20-11-14-35-17-22(20)25(31-26)19-7-3-2-4-8-19/h5-6,9-10,18-19H,2-4,7-8,11-14,16-17H2,1H3,(H,30,34)/t18-/m1/s1	YGQCYRLCWPURIF-GOSISDBHSA-N	326603	US9662327, Compound 300	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326603	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326603&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282927	384581555							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642492	CC(C)[C@@H]1CN(CCN1C(=O)Nc1ccc(C)cc1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C29H37N5O2/c1-18(2)25-16-33(12-13-34(25)28(35)31-21-10-6-19(3)7-11-21)27-23(15-30)22-14-29(4,5)36-17-24(22)26(32-27)20-8-9-20/h6-7,10-11,18,20,25H,8-9,12-14,16-17H2,1-5H3,(H,31,35)/t25-/m0/s1	NIRGESHRORLXQH-VWLOTQADSA-N	326604	US9662327, Compound 301	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326604	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326604&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282744	384581556							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642493	CC(C)[C@@H]1CN(CCN1S(=O)(=O)c1ccc(C)cc1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C28H36N4O3S/c1-18(2)25-16-31(12-13-32(25)36(33,34)21-10-6-19(3)7-11-21)27-23(15-29)22-14-28(4,5)35-17-24(22)26(30-27)20-8-9-20/h6-7,10-11,18,20,25H,8-9,12-14,16-17H2,1-5H3/t25-/m0/s1	NCEIVARGAOAQPD-VWLOTQADSA-N	326605	US9662327, Compound 302	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326605	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326605&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119334	384581557							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642494	CC(C)[C@@H]1CN(CCN1C(=O)Nc1ccc(cc1)C#N)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C29H34N6O2/c1-18(2)25-16-34(11-12-35(25)28(36)32-21-9-5-19(14-30)6-10-21)27-23(15-31)22-13-29(3,4)37-17-24(22)26(33-27)20-7-8-20/h5-6,9-10,18,20,25H,7-8,11-13,16-17H2,1-4H3,(H,32,36)/t25-/m0/s1	ZORHYGYEEGIFHH-VWLOTQADSA-N	326606	US9662327, Compound 303	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326606	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326606&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71477439	384581558							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642495	CCCc1c(CO)c(nc(N(CC)C[C@H](NC(=O)NCC=C)C(C)C)c1C#N)C1CC1	InChI=1S/C24H37N5O2/c1-6-9-18-19(13-25)23(28-22(17-10-11-17)20(18)15-30)29(8-3)14-21(16(4)5)27-24(31)26-12-7-2/h7,16-17,21,30H,2,6,8-12,14-15H2,1,3-5H3,(H2,26,27,31)/t21-/m0/s1	DXPWQOGXLQVPQH-NRFANRHFSA-N	326607	US9662327, Compound 304	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326607	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326607&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295135	384581559							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642496	CC(C)[C@@H]1CN(CCN1C(=O)C1CCOCC1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H38N4O3/c1-17(2)23-15-30(9-10-31(23)26(32)19-7-11-33-12-8-19)25-21(14-28)20-13-27(3,4)34-16-22(20)24(29-25)18-5-6-18/h17-19,23H,5-13,15-16H2,1-4H3/t23-/m0/s1	XPEXHIQWUHLNFO-QHCPKHFHSA-N	326608	US9662327, Compound 305	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326608	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326608&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295136	384581560							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642497	CC(C)[C@@H]1CN(CCN1C(O)OC(C)(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H40N4O3/c1-16(2)21-14-29(10-11-30(21)24(31)33-25(3,4)5)23-19(13-27)18-12-26(6,7)32-15-20(18)22(28-23)17-8-9-17/h16-17,21,24,31H,8-12,14-15H2,1-7H3/t21-,24?/m0/s1	LRCVCHTVSZWNCV-XEGCMXMBSA-N	326609	US9662327, Compound 306	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326609	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326609&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295137	384581561					C01707		1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642498	COCCOC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H38N4O4/c1-16(2)21-14-28(8-9-29(21)24(30)32-11-10-31-7)23-19(13-26)18-12-25(5,6)33-15-20(18)22(27-23)17(3)4/h16-17,21H,8-12,14-15H2,1-7H3/t21-/m0/s1	NAZJIFDHVXOUAI-NRFANRHFSA-N	326610	US9662327, Compound 307	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326610	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326610&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295138	384581562							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642499	CC(C)Cc1c(CO)c(nc(N2C[C@@H](C)N(C[C@@H]2C)C(O)c2ccoc2)c1C#N)C1CC1	InChI=1S/C25H34N4O3/c1-15(2)9-20-21(10-26)24(27-23(18-5-6-18)22(20)13-30)28-11-17(4)29(12-16(28)3)25(31)19-7-8-32-14-19/h7-8,14-18,25,30-31H,5-6,9,11-13H2,1-4H3/t16-,17+,25?/m0/s1	IWRVJEHKAIDNAN-WAPIFTKLSA-N	326611	US9662327, Compound 308	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326611	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326611&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295139	384581563							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642500	C[C@@H]1CN([C@@H](C)CN1C(=O)Cc1cccs1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H32N4O2S/c1-16-14-30(17(2)13-29(16)23(31)10-19-6-5-9-33-19)25-21(12-27)20-11-26(3,4)32-15-22(20)24(28-25)18-7-8-18/h5-6,9,16-18H,7-8,10-11,13-15H2,1-4H3/t16-,17+/m1/s1	DXYAXVGFBWXONF-SJORKVTESA-N	326612	US9662327, Compound 309	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326612	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326612&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295140	384581564							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642501	COCCC(=O)N1C[C@H](C)N(C[C@H]1C)c1nc(C2CC2)c(CO)c(CC(C)C)c1C#N	InChI=1S/C24H36N4O3/c1-15(2)10-19-20(11-25)24(26-23(18-6-7-18)21(19)14-29)28-13-16(3)27(12-17(28)4)22(30)8-9-31-5/h15-18,29H,6-10,12-14H2,1-5H3/t16-,17+/m1/s1	ZGJKNCSVAWISOM-SJORKVTESA-N	326613	US9662327, Compound 310	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326613	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326613&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166697	384581565							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642502	CCOC(=O)C1CN(CCN1C(=O)CCOC)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H36N4O5/c1-7-33-24(31)20-14-28(9-10-29(20)21(30)8-11-32-6)23-18(13-26)17-12-25(4,5)34-15-19(17)22(27-23)16(2)3/h16,20H,7-12,14-15H2,1-6H3	OGTILKRXGDGQHO-UHFFFAOYSA-N	326614	US9662327, Compound 311	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326614	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326614&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118679	384581566							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642503	COCCC(=O)N1CCN(C[C@H]1C)c1nc(C2CCCCC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H38N4O3/c1-18-16-29(11-12-30(18)23(31)10-13-32-4)25-21(15-27)20-14-26(2,3)33-17-22(20)24(28-25)19-8-6-5-7-9-19/h18-19H,5-14,16-17H2,1-4H3/t18-/m1/s1	RWYBKNXHUVWHLY-GOSISDBHSA-N	326615	US9662327, Compound 312	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326615	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326615&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282709	384581567							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642504	CCOC(=O)C1CN(CCN1C(=O)CCSC)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C26H36N4O4S/c1-3-34-26(32)22-16-29(11-12-30(22)23(31)10-14-35-2)25-20(15-27)19-9-13-33-17-21(19)24(28-25)18-7-5-4-6-8-18/h18,22H,3-14,16-17H2,1-2H3	DHJGOCYTZSTJBT-UHFFFAOYSA-N	326616	US9662327, Compound 313	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326616	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326616&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118823	384581568							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642505	CCOC(=O)C1CN(CCN1C(=O)c1ccco1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C27H32N4O5/c1-2-35-27(33)22-16-30(11-12-31(22)26(32)23-9-6-13-36-23)25-20(15-28)19-10-14-34-17-21(19)24(29-25)18-7-4-3-5-8-18/h6,9,13,18,22H,2-5,7-8,10-12,14,16-17H2,1H3	CJYICBXIVGYDKN-UHFFFAOYSA-N	326617	US9662327, Compound 314	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326617	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326617&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295142	384581569							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642506	CCOC(=O)C1CN(CCN1C(=O)OCCOC)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C26H36N4O6/c1-3-35-25(31)22-16-29(10-11-30(22)26(32)36-14-13-33-2)24-20(15-27)19-9-12-34-17-21(19)23(28-24)18-7-5-4-6-8-18/h18,22H,3-14,16-17H2,1-2H3	IDRNDQFVTQJARR-UHFFFAOYSA-N	326618	US9662327, Compound 315	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326618	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326618&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118843	384581570							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642507	COc1ccc(NC(=O)N2CCN(C[C@H]2C(C)C)c2nc(C3CC3)c3COC(C)(C)Cc3c2C#N)cc1	InChI=1S/C29H37N5O3/c1-18(2)25-16-33(12-13-34(25)28(35)31-20-8-10-21(36-5)11-9-20)27-23(15-30)22-14-29(3,4)37-17-24(22)26(32-27)19-6-7-19/h8-11,18-19,25H,6-7,12-14,16-17H2,1-5H3,(H,31,35)/t25-/m0/s1	RZLMSFZHCMEIBY-VWLOTQADSA-N	326619	US9662327, Compound 316	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326619	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326619&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283462	384581571							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642508	CC(C)[C@@H]1CN(CCN1C(=O)CCl)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C23H31ClN4O2/c1-14(2)19-12-27(7-8-28(19)20(29)10-24)22-17(11-25)16-9-23(3,4)30-13-18(16)21(26-22)15-5-6-15/h14-15,19H,5-10,12-13H2,1-4H3/t19-/m0/s1	AKVVJZWILQODGB-IBGZPJMESA-N	326620	US9662327, Compound 317	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326620	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326620&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71476965	384581572							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642509	CC1(C)Cc2c(CO1)c(nc(N1CCN(C(=O)c3ccoc3)C(C)(C)C1)c2C#N)C1CC1	InChI=1S/C25H30N4O3/c1-24(2)15-28(8-9-29(24)23(30)17-7-10-31-13-17)22-19(12-26)18-11-25(3,4)32-14-20(18)21(27-22)16-5-6-16/h7,10,13,16H,5-6,8-9,11,14-15H2,1-4H3	SCXFELACQFBQLF-UHFFFAOYSA-N	326621	US9662327, Compound 318	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326621	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326621&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282968	384581573							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642510	CC1(C)Cc2c(CO1)c(nc(N1CCN(C(=O)c3ccco3)C(C)(C)C1)c2C#N)C1CC1	InChI=1S/C25H30N4O3/c1-24(2)15-28(9-10-29(24)23(30)20-6-5-11-31-20)22-18(13-26)17-12-25(3,4)32-14-19(17)21(27-22)16-7-8-16/h5-6,11,16H,7-10,12,14-15H2,1-4H3	NNCFUAKJVHJZAR-UHFFFAOYSA-N	326622	US9662327, Compound 319	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326622	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326622&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295143	384581574							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642511	CSCCC(=O)N1CCN(CC1(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H34N4O2S/c1-23(2)15-27(9-10-28(23)20(29)8-11-31-5)22-18(13-25)17-12-24(3,4)30-14-19(17)21(26-22)16-6-7-16/h16H,6-12,14-15H2,1-5H3	AEDWTYBGHPJLEU-UHFFFAOYSA-N	326623	US9662327, Compound 320	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326623	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326623&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282853	384581575							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642512	Cc1occc1C(=O)N1CCN(CC1(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H32N4O3/c1-16-18(8-11-32-16)24(31)30-10-9-29(15-25(30,2)3)23-20(13-27)19-12-26(4,5)33-14-21(19)22(28-23)17-6-7-17/h8,11,17H,6-7,9-10,12,14-15H2,1-5H3	ANBXYQLGQHRMMG-UHFFFAOYSA-N	326624	US9662327, Compound 321	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326624	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326624&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295145	384581576							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642513	CC(C)[C@@H]1CN(CCN1CCCOC(C)=O)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H38N4O3/c1-17(2)23-15-30(11-10-29(23)9-6-12-32-18(3)31)25-21(14-27)20-13-26(4,5)33-16-22(20)24(28-25)19-7-8-19/h17,19,23H,6-13,15-16H2,1-5H3/t23-/m0/s1	SBJXNPFNYINNSV-QHCPKHFHSA-N	326625	US9662327, Compound 322	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326625	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326625&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166698	384581577							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642514	CC(C)[C@@H]1CN(CCN1S(C)(=O)=O)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C22H32N4O3S/c1-14(2)19-12-25(8-9-26(19)30(5,27)28)21-17(11-23)16-10-22(3,4)29-13-18(16)20(24-21)15-6-7-15/h14-15,19H,6-10,12-13H2,1-5H3/t19-/m0/s1	YGSFGZFPRBZENY-IBGZPJMESA-N	326626	US9662327, Compound 323	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326626	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326626&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283080	384581578							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642515	CC(C)[C@@H]1CN(CCN1C(=O)Cn1cncn1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C25H35N7O2/c1-16(2)21-11-30(7-8-32(21)22(33)12-31-15-27-14-28-31)24-19(10-26)18-9-25(3,4)34-13-20(18)23(29-24)17-5-6-17/h10,14-17,21,26H,5-9,11-13H2,1-4H3/t21-/m0/s1	JPMUICRQOFAYOX-NRFANRHFSA-N	326627	US9662327, Compound 324	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326627	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326627&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295149	384581579							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642516	CC(C)[C@@H]1CN(CCN1C(=O)Cn1cccn1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C26H36N6O2/c1-17(2)22-14-30(10-11-32(22)23(33)15-31-9-5-8-28-31)25-20(13-27)19-12-26(3,4)34-16-21(19)24(29-25)18-6-7-18/h5,8-9,13,17-18,22,27H,6-7,10-12,14-16H2,1-4H3/t22-/m0/s1	DPUJNXIWMREMGM-QFIPXVFZSA-N	326628	US9662327, Compound 325	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326628	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326628&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295147	384581580							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642517	CCCc1c(CO)c(nc(N2CCN([C@@H](C2)C(C)C)C(=O)NCC)c1C#N)C1CC1	InChI=1S/C23H35N5O2/c1-5-7-17-18(12-24)22(26-21(16-8-9-16)19(17)14-29)27-10-11-28(23(30)25-6-2)20(13-27)15(3)4/h15-16,20,29H,5-11,13-14H2,1-4H3,(H,25,30)/t20-/m0/s1	ZFQVWAXLKCCZGD-FQEVSTJZSA-N	326629	US9662327, Compound 326	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326629	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326629&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166700	384581581							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642518	CCCCCNC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H41N5O2/c1-6-7-8-11-29-26(33)32-13-12-31(16-23(32)18(2)3)25-21(15-28)20-14-27(4,5)34-17-22(20)24(30-25)19-9-10-19/h18-19,23H,6-14,16-17H2,1-5H3,(H,29,33)/t23-/m0/s1	HPVOOMRPUNYSJR-QHCPKHFHSA-N	326631	US9662327, Compound 327	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326631	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326631&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295150	384581583							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642519	CCCc1c(CO)c(nc(N2CCN([C@@H](C2)C(C)C)C(=O)NCc2ccccc2)c1C#N)C1CC1	InChI=1S/C28H37N5O2/c1-4-8-22-23(15-29)27(31-26(21-11-12-21)24(22)18-34)32-13-14-33(25(17-32)19(2)3)28(35)30-16-20-9-6-5-7-10-20/h5-7,9-10,19,21,25,34H,4,8,11-14,16-18H2,1-3H3,(H,30,35)/t25-/m0/s1	HGVFSWQVSUCIHO-VWLOTQADSA-N	326632	US9662327, Compound 328	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326632	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326632&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166702	384581584							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642520	CCCCOC(=O)N1CCN(CC1C(=O)OCC)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H38N4O5/c1-7-9-12-34-25(32)30-11-10-29(15-21(30)24(31)33-8-2)23-19(14-27)18-13-26(5,6)35-16-20(18)22(28-23)17(3)4/h17,21H,7-13,15-16H2,1-6H3	LPNUTUJQSWDCJP-UHFFFAOYSA-N	326663	US9662327, Compound 329	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326663	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326663&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166699	384581615							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642521	CCOC(=O)C1CN(CCN1C(=O)NCC=C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C26H35N5O4/c1-3-11-28-26(33)31-13-12-30(16-22(31)25(32)35-4-2)24-20(15-27)19-10-14-34-17-21(19)23(29-24)18-8-6-5-7-9-18/h3,18,22H,1,4-14,16-17H2,2H3,(H,28,33)	KTYHPISGPAGRMH-UHFFFAOYSA-N	326679	US9662327, Compound 330	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326679	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326679&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283163	384581631							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642522	CCOC(=O)C1CN(CCN1C(=O)NCC=C)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H35N5O4/c1-7-9-27-24(32)30-11-10-29(14-20(30)23(31)33-8-2)22-18(13-26)17-12-25(5,6)34-15-19(17)21(28-22)16(3)4/h7,16,20H,1,8-12,14-15H2,2-6H3,(H,27,32)	PPXIMHZURWSBCZ-UHFFFAOYSA-N	326692	US9662327, Compound 331	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326692	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326692&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89288118	384581644							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642523	CCOC(=O)C1CN(CCN1C(=O)Cc1cccs1)c1nc(C(C)C)c2COC(C)(C)Cc2c1C=N	InChI=1S/C27H36N4O4S/c1-6-34-26(33)22-15-30(9-10-31(22)23(32)12-18-8-7-11-36-18)25-20(14-28)19-13-27(4,5)35-16-21(19)24(29-25)17(2)3/h7-8,11,14,17,22,28H,6,9-10,12-13,15-16H2,1-5H3	FGEGKACZBKMEEY-UHFFFAOYSA-N	326747	US9662327, Compound 332	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326747	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326747&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295153	384581699							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642524	CCOC(=O)C1CN(CCN1C(=O)OC)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C23H32N4O5/c1-7-31-21(28)18-12-26(8-9-27(18)22(29)30-6)20-16(11-24)15-10-23(4,5)32-13-17(15)19(25-20)14(2)3/h14,18H,7-10,12-13H2,1-6H3	RDCDFOIVKMOJDP-UHFFFAOYSA-N	326748	US9662327, Compound 333	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326748	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326748&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118981	384581700							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642525	C[C@@H]1CN(CCN1C(O)NCC=C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C24H35N5O2/c1-3-10-26-24(30)29-12-11-28(15-17(29)2)23-20(14-25)19-9-13-31-16-21(19)22(27-23)18-7-5-4-6-8-18/h3,17-18,24,26,30H,1,4-13,15-16H2,2H3/t17-,24?/m1/s1	WWHDJBYISRTCHJ-BPNWFJGMSA-N	326749	US9662327, Compound 334	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326749	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326749&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295154	384581701							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642526	CCNC(=O)N1CCN(C[C@H]1C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C23H33N5O2/c1-3-25-23(29)28-11-10-27(14-16(28)2)22-19(13-24)18-9-12-30-15-20(18)21(26-22)17-7-5-4-6-8-17/h16-17H,3-12,14-15H2,1-2H3,(H,25,29)/t16-/m1/s1	VUDOSEFVEGWYLL-MRXNPFEDSA-N	326750	US9662327, Compound 335	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326750	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326750&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119197	384581702							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642527	C[C@@H]1CN(CCN1S(C)(=O)=O)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C21H30N4O3S/c1-15-13-24(9-10-25(15)29(2,26)27)21-18(12-22)17-8-11-28-14-19(17)20(23-21)16-6-4-3-5-7-16/h15-16H,3-11,13-14H2,1-2H3/t15-/m1/s1	RVYHCOFQWRIIHQ-OAHLLOKOSA-N	326751	US9662327, Compound 336	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326751	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326751&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119369	384581703							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642528	COc1ccc(OC(=O)N2CCN(C[C@H]2C(C)C)c2nc(C3CC3)c3COC(C)(C)Cc3c2N)cc1	InChI=1S/C28H38N4O4/c1-17(2)23-15-31(12-13-32(23)27(33)36-20-10-8-19(34-5)9-11-20)26-24(29)21-14-28(3,4)35-16-22(21)25(30-26)18-6-7-18/h8-11,17-18,23H,6-7,12-16,29H2,1-5H3/t23-/m0/s1	BQHBEIMFFUBEDM-QHCPKHFHSA-N	326752	US9662327, Compound 337	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326752	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326752&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166701	384581704							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642529	CON(C)CC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H37N5O3/c1-16(2)21-13-29(9-10-30(21)22(31)14-28(5)32-6)24-19(12-26)18-11-25(3,4)33-15-20(18)23(27-24)17-7-8-17/h16-17,21H,7-11,13-15H2,1-6H3/t21-/m0/s1	HJSFGBULZMPVPZ-NRFANRHFSA-N	326753	US9662327, Compound 338	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326753	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326753&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295156	384581705							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642530	CC(C)COC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H38N4O3/c1-16(2)14-32-25(31)30-10-9-29(13-22(30)17(3)4)24-20(12-27)19-11-26(5,6)33-15-21(19)23(28-24)18-7-8-18/h16-18,22H,7-11,13-15H2,1-6H3/t22-/m0/s1	XWKJSQVPMQGLPS-QFIPXVFZSA-N	326754	US9662327, Compound 339	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326754	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326754&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119568	384581706							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642531	C[C@@H]1CN(CCN1C(=O)CCl)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C22H29ClN4O2/c1-15-13-26(8-9-27(15)20(28)11-23)22-18(12-24)17-7-10-29-14-19(17)21(25-22)16-5-3-2-4-6-16/h15-16H,2-11,13-14H2,1H3/t15-/m1/s1	NJZYADMAWDSYQY-OAHLLOKOSA-N	326755	US9662327, Compound 340	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326755	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326755&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282776	384581707							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642532	COCC(=O)N1CCN(C[C@H]1C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C23H32N4O3/c1-16-13-26(9-10-27(16)21(28)15-29-2)23-19(12-24)18-8-11-30-14-20(18)22(25-23)17-6-4-3-5-7-17/h16-17H,3-11,13-15H2,1-2H3/t16-/m1/s1	XEVDZQQNGXTDPE-MRXNPFEDSA-N	326756	US9662327, Compound 341	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326756	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326756&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295158	384581708							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642533	COC(=O)CN1CCN(C[C@H]1C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C23H32N4O3/c1-16-13-27(10-9-26(16)14-21(28)29-2)23-19(12-24)18-8-11-30-15-20(18)22(25-23)17-6-4-3-5-7-17/h16-17H,3-11,13-15H2,1-2H3/t16-/m1/s1	IKXQCRWPOAKWLM-MRXNPFEDSA-N	326757	US9662327, Compound 342	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326757	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326757&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119421	384581709							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642534	C[C@@H]1CN(CCN1C(=O)OCc1ccccc1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C28H34N4O3/c1-20-17-31(13-14-32(20)28(33)35-18-21-8-4-2-5-9-21)27-24(16-29)23-12-15-34-19-25(23)26(30-27)22-10-6-3-7-11-22/h2,4-5,8-9,20,22H,3,6-7,10-15,17-19H2,1H3/t20-/m1/s1	HMXTXLZSBLYONW-HXUWFJFHSA-N	326758	US9662327, Compound 343	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326758	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326758&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295160	384581710							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642535	CNC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C23H33N5O2/c1-14(2)19-12-27(8-9-28(19)22(29)25-5)21-17(11-24)16-10-23(3,4)30-13-18(16)20(26-21)15-6-7-15/h14-15,19H,6-10,12-13H2,1-5H3,(H,25,29)/t19-/m0/s1	IZDTXKLGWULNQV-IBGZPJMESA-N	326759	US9662327, Compound 344	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326759	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326759&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166703	384581711							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642536	CCOCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C(C)C)c2COC(C)Cc2c1C#N	InChI=1S/C24H36N4O3/c1-7-30-14-22(29)28-9-8-27(12-21(28)15(2)3)24-19(11-25)18-10-17(6)31-13-20(18)23(26-24)16(4)5/h15-17,21H,7-10,12-14H2,1-6H3/t17?,21-/m0/s1	UJHDGIGNYNJTDY-LFABVHOISA-N	326760	US9662327, Compound 345	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326760	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326760&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166704	384581712							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642537	COC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)Cc2c1C#N	InChI=1S/C22H30N4O3/c1-13(2)19-11-25(7-8-26(19)22(27)28-4)21-17(10-23)16-9-14(3)29-12-18(16)20(24-21)15-5-6-15/h13-15,19H,5-9,11-12H2,1-4H3/t14?,19-/m0/s1	WLOQVCSMIAHSBL-PKDNWHCCSA-N	326761	US9662327, Compound 346	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326761	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326761&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166705	384581713							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642538	COCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H34N4O3/c1-15(2)20-12-27(8-9-28(20)21(29)14-30-5)23-18(11-25)17-10-24(3,4)31-13-19(17)22(26-23)16-6-7-16/h15-16,20H,6-10,12-14H2,1-5H3/t20-/m0/s1	WPTPMZVJEGXGPB-FQEVSTJZSA-N	326762	US9662327, Compound 347	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326762	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326762&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119289	384581714							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642539	CC(C)[C@@H]1CN(CCN1C(=O)COCCO)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H36N4O4/c1-16(2)21-13-28(7-8-29(21)22(31)15-32-10-9-30)24-19(12-26)18-11-25(3,4)33-14-20(18)23(27-24)17-5-6-17/h16-17,21,30H,5-11,13-15H2,1-4H3/t21-/m0/s1	UKVIZKHNGTWZLZ-NRFANRHFSA-N	326763	US9662327, Compound 348	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326763	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326763&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295163	384581715							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642540	CC(C)[C@@H]1CN(CCN1C(=O)NCCO)c1nc(C2CC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C24H37N5O3/c1-15(2)20-13-28(8-9-29(20)23(31)26-7-10-30)22-18(12-25)17-11-24(3,4)32-14-19(17)21(27-22)16-5-6-16/h12,15-16,20,25,30H,5-11,13-14H2,1-4H3,(H,26,31)/t20-/m0/s1	WCLBTAYNNGACAB-FQEVSTJZSA-N	326764	US9662327, Compound 349	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326764	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326764&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295164	384581716					C04080		1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642541	CCCNC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c(CO)c(CCC)c1C#N	InChI=1S/C24H37N5O2/c1-5-7-18-19(13-25)23(27-22(17-8-9-17)20(18)15-30)28-11-12-29(21(14-28)16(3)4)24(31)26-10-6-2/h16-17,21,30H,5-12,14-15H2,1-4H3,(H,26,31)/t21-/m0/s1	SLYHVJGHVHTABJ-NRFANRHFSA-N	326765	US9662327, Compound 350	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326765	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326765&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166706	384581717							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642542	CC(C)[C@@H]1CN(CCN1C(=O)N(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H35N5O2/c1-15(2)20-13-28(9-10-29(20)23(30)27(5)6)22-18(12-25)17-11-24(3,4)31-14-19(17)21(26-22)16-7-8-16/h15-16,20H,7-11,13-14H2,1-6H3/t20-/m0/s1	WTULACKFDNMNDA-FQEVSTJZSA-N	326766	US9662327, Compound 351	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326766	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326766&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295166	384581718							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642543	CC(C)[C@@H]1CN(CCN1C(C)=O)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C23H32N4O2/c1-14(2)20-12-26(8-9-27(20)15(3)28)22-18(11-24)17-10-23(4,5)29-13-19(17)21(25-22)16-6-7-16/h14,16,20H,6-10,12-13H2,1-5H3/t20-/m0/s1	RFBJTOSIGHYGGH-FQEVSTJZSA-N	326767	US9662327, Compound 352	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326767	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326767&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295167	384581719							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642544	COCCNC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H37N5O3/c1-16(2)21-14-29(9-10-30(21)24(31)27-8-11-32-5)23-19(13-26)18-12-25(3,4)33-15-20(18)22(28-23)17-6-7-17/h16-17,21H,6-12,14-15H2,1-5H3,(H,27,31)/t21-/m0/s1	WXAYAQQDKLGRHS-NRFANRHFSA-N	326768	US9662327, Compound 353	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326768	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326768&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295168	384581720							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642545	CCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H34N4O2/c1-6-21(29)28-10-9-27(13-20(28)15(2)3)23-18(12-25)17-11-24(4,5)30-14-19(17)22(26-23)16-7-8-16/h15-16,20H,6-11,13-14H2,1-5H3/t20-/m0/s1	JOBKFUWILCMHEB-FQEVSTJZSA-N	326769	US9662327, Compound 354	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326769	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326769&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283220	384581721							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642546	CC(C)[C@@H]1CN(CCN1C(=O)NCC#C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C25H35N5O2/c1-6-9-27-24(31)30-11-10-29(14-21(30)16(2)3)23-19(13-26)18-12-25(4,5)32-15-20(18)22(28-23)17-7-8-17/h1,13,16-17,21,26H,7-12,14-15H2,2-5H3,(H,27,31)/t21-/m0/s1	HZUATZYGCNKAPD-NRFANRHFSA-N	326770	US9662327, Compound 355	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326770	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326770&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295169	384581722							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642547	COCCC(=O)N1[C@@H](C)CN(C[C@H]1C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H34N4O3/c1-15-12-27(13-16(2)28(15)21(29)8-9-30-5)23-19(11-25)18-10-24(3,4)31-14-20(18)22(26-23)17-6-7-17/h15-17H,6-10,12-14H2,1-5H3/t15-,16+	PBEPKWCSAXSCQO-IYBDPMFKSA-N	326771	US9662327, Compound 356	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326771	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326771&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295170	384581723							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642548	CNC(=O)N1CCN(C[C@H]1C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C22H31N5O2/c1-15-13-26(9-10-27(15)22(28)24-2)21-18(12-23)17-8-11-29-14-19(17)20(25-21)16-6-4-3-5-7-16/h15-16H,3-11,13-14H2,1-2H3,(H,24,28)/t15-/m1/s1	XCWUKJITXZMDDQ-OAHLLOKOSA-N	326772	US9662327, Compound 357	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326772	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326772&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118985	384581724							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642549	CCOC(=O)N1CCN(C[C@H]1C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C23H32N4O3/c1-3-30-23(28)27-11-10-26(14-16(27)2)22-19(13-24)18-9-12-29-15-20(18)21(25-22)17-7-5-4-6-8-17/h16-17H,3-12,14-15H2,1-2H3/t16-/m1/s1	GTKGIVUFFNFFBI-MRXNPFEDSA-N	326773	US9662327, Compound 358	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326773	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326773&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295172	384581725							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642550	CCCOC(=O)N1CCN(C[C@H]1C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C24H34N4O3/c1-3-12-31-24(29)28-11-10-27(15-17(28)2)23-20(14-25)19-9-13-30-16-21(19)22(26-23)18-7-5-4-6-8-18/h17-18H,3-13,15-16H2,1-2H3/t17-/m1/s1	SSYWCZKWDWMHLI-QGZVFWFLSA-N	326774	US9662327, Compound 359	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326774	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326774&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295171	384581726							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642551	C[C@@H]1CN(CCN1C(=O)NC1CC1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C24H33N5O2/c1-16-14-28(10-11-29(16)24(30)26-18-7-8-18)23-20(13-25)19-9-12-31-15-21(19)22(27-23)17-5-3-2-4-6-17/h16-18H,2-12,14-15H2,1H3,(H,26,30)/t16-/m1/s1	MKPYPUPIXFJABK-MRXNPFEDSA-N	326775	US9662327, Compound 360	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326775	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326775&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119161	384581727							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642552	C[C@@H]1CN(CCN1C(=O)NCC#C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C24H31N5O2/c1-3-10-26-24(30)29-12-11-28(15-17(29)2)23-20(14-25)19-9-13-31-16-21(19)22(27-23)18-7-5-4-6-8-18/h1,17-18H,4-13,15-16H2,2H3,(H,26,30)/t17-/m1/s1	ZPGSFEXOPKFDKD-QGZVFWFLSA-N	326776	US9662327, Compound 361	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326776	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326776&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283211	384581728							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642553	C[C@@H]1CN(CCN1C(C)=O)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C22H30N4O2/c1-15-13-25(9-10-26(15)16(2)27)22-19(12-23)18-8-11-28-14-20(18)21(24-22)17-6-4-3-5-7-17/h15,17H,3-11,13-14H2,1-2H3/t15-/m1/s1	QOGSIDYCWGMXQI-OAHLLOKOSA-N	326777	US9662327, Compound 362	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326777	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326777&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282999	384581729							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642554	CCC(=O)N1CCN(C[C@H]1C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C23H32N4O2/c1-3-21(28)27-11-10-26(14-16(27)2)23-19(13-24)18-9-12-29-15-20(18)22(25-23)17-7-5-4-6-8-17/h16-17H,3-12,14-15H2,1-2H3/t16-/m1/s1	YDMQQMQLTSBZQW-MRXNPFEDSA-N	326778	US9662327, Compound 363	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326778	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326778&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283006	384581730							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642555	CCCOC(=O)N1CCN(CC1C(=O)OCC)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H36N4O5/c1-7-11-33-24(31)29-10-9-28(14-20(29)23(30)32-8-2)22-18(13-26)17-12-25(5,6)34-15-19(17)21(27-22)16(3)4/h16,20H,7-12,14-15H2,1-6H3	AGFINNIKOUKHHK-UHFFFAOYSA-N	326779	US9662327, Compound 364	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326779	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326779&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119013	384581731							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642556	CC(C)[C@@H]1CN(CCN1C(=O)NCC1CC1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H37N5O2/c1-16(2)22-14-30(9-10-31(22)25(32)28-13-17-5-6-17)24-20(12-27)19-11-26(3,4)33-15-21(19)23(29-24)18-7-8-18/h16-18,22H,5-11,13-15H2,1-4H3,(H,28,32)/t22-/m0/s1	ZZEVMMJJMJWOCU-QFIPXVFZSA-N	326780	US9662327, Compound 365	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326780	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326780&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295175	384581732							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642557	CC(C)Cc1c(CO)c(nc(N2CCN([C@@H](C2)C(C)C)C(=O)CCOc2ccccc2)c1C#N)C1CC1	InChI=1S/C30H40N4O3/c1-20(2)16-24-25(17-31)30(32-29(22-10-11-22)26(24)19-35)33-13-14-34(27(18-33)21(3)4)28(36)12-15-37-23-8-6-5-7-9-23/h5-9,20-22,27,35H,10-16,18-19H2,1-4H3/t27-/m0/s1	FVEYDMYYIRDMPY-MHZLTWQESA-N	326781	US9662327, Compound 366	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326781	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326781&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295173	384581733							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642558	CCOC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H34N4O3/c1-6-30-23(29)28-10-9-27(13-20(28)15(2)3)22-18(12-25)17-11-24(4,5)31-14-19(17)21(26-22)16-7-8-16/h15-16,20H,6-11,13-14H2,1-5H3/t20-/m0/s1	CIWJSMIRSXATGY-FQEVSTJZSA-N	326782	US9662327, Compound 367	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326782	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326782&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295174	384581734							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642559	CC(C)[C@@H]1CN(CCN1C(=O)OCCO)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H34N4O4/c1-15(2)20-13-27(7-8-28(20)23(30)31-10-9-29)22-18(12-25)17-11-24(3,4)32-14-19(17)21(26-22)16-5-6-16/h15-16,20,29H,5-11,13-14H2,1-4H3/t20-/m0/s1	IYMUJXJMXJJMFL-FQEVSTJZSA-N	326783	US9662327, Compound 368	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326783	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326783&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119079	384581735							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642560	COCCN1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H36N4O2/c1-16(2)21-14-28(9-8-27(21)10-11-29-5)23-19(13-25)18-12-24(3,4)30-15-20(18)22(26-23)17-6-7-17/h16-17,21H,6-12,14-15H2,1-5H3/t21-/m0/s1	UEBSEKDTRRFJIG-NRFANRHFSA-N	326784	US9662327, Compound 369	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326784	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326784&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283118	384581736							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642561	CC(C)[C@@H]1CN(CCN1C(O)OCC1CC1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H38N4O3/c1-16(2)22-13-29(9-10-30(22)25(31)32-14-17-5-6-17)24-20(12-27)19-11-26(3,4)33-15-21(19)23(28-24)18-7-8-18/h16-18,22,25,31H,5-11,13-15H2,1-4H3/t22-,25?/m0/s1	XNGCAOXPHMMAOK-XADRRFQNSA-N	326785	US9662327, Compound 370	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326785	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326785&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166707	384581737					C01707		1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642562	CCCOC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C25H38N4O3/c1-6-11-31-24(30)29-10-9-28(14-21(29)16(2)3)23-19(13-26)18-12-25(4,5)32-15-20(18)22(27-23)17-7-8-17/h13,16-17,21,26H,6-12,14-15H2,1-5H3/t21-/m0/s1	XDLFZXJPUWXSGB-NRFANRHFSA-N	326786	US9662327, Compound 371	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326786	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326786&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295178	384581738							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642563	CC(C)[C@@H]1CN(CCN1C(=O)CNC1CC1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H37N5O2/c1-16(2)22-14-30(9-10-31(22)23(32)13-28-18-7-8-18)25-20(12-27)19-11-26(3,4)33-15-21(19)24(29-25)17-5-6-17/h16-18,22,28H,5-11,13-15H2,1-4H3/t22-/m0/s1	HJYXFRSQEZTWMV-QFIPXVFZSA-N	326787	US9662327, Compound 372	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326787	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326787&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71476966	384581739							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642564	CC(C)[C@@H]1CN(CCN1C(=O)CNCC#C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H35N5O2/c1-6-9-28-14-23(32)31-11-10-30(15-22(31)17(2)3)25-20(13-27)19-12-26(4,5)33-16-21(19)24(29-25)18-7-8-18/h1,17-18,22,28H,7-12,14-16H2,2-5H3/t22-/m0/s1	WSGMCRVXGKVVRE-QFIPXVFZSA-N	326788	US9662327, Compound 373	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326788	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326788&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283414	384581740							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642565	CC(C)[C@@H]1CN(CCN1C(=O)Cn1ccnc1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H34N6O2/c1-17(2)22-13-31(9-10-32(22)23(33)14-30-8-7-28-16-30)25-20(12-27)19-11-26(3,4)34-15-21(19)24(29-25)18-5-6-18/h7-8,16-18,22H,5-6,9-11,13-15H2,1-4H3/t22-/m0/s1	IHNDNBYOAOPMME-QFIPXVFZSA-N	326789	US9662327, Compound 374	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326789	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326789&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283360	384581741							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642566	C[C@@H]1CN(CCN1C(=O)C1CC1)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C24H32N4O2/c1-16-14-27(10-11-28(16)24(29)18-7-8-18)23-20(13-25)19-9-12-30-15-21(19)22(26-23)17-5-3-2-4-6-17/h16-18H,2-12,14-15H2,1H3/t16-/m1/s1	RDMDIJNODCWAFT-MRXNPFEDSA-N	326790	US9662327, Compound 375	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326790	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326790&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283713	384581742							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642567	CC(C)[C@@H]1CN(CCN1C(=O)C1CC1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H34N4O2/c1-15(2)21-13-28(9-10-29(21)24(30)17-7-8-17)23-19(12-26)18-11-25(3,4)31-14-20(18)22(27-23)16-5-6-16/h15-17,21H,5-11,13-14H2,1-4H3/t21-/m0/s1	KIQPNCNEGIYFFL-NRFANRHFSA-N	326791	US9662327, Compound 376	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326791	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326791&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71137208	384581743							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642568	CC(C)[C@@H]1CN(CCN1C(=O)C1(C)CC1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H36N4O2/c1-16(2)21-14-29(10-11-30(21)24(31)26(5)8-9-26)23-19(13-27)18-12-25(3,4)32-15-20(18)22(28-23)17-6-7-17/h16-17,21H,6-12,14-15H2,1-5H3/t21-/m0/s1	HIZCLGFXXHXCLG-NRFANRHFSA-N	326792	US9662327, Compound 377	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326792	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326792&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295179	384581744							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642569	CCCNC(=O)N1CCN(C[C@H]1C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C24H35N5O2/c1-3-10-26-24(30)29-12-11-28(15-17(29)2)23-20(14-25)19-9-13-31-16-21(19)22(27-23)18-7-5-4-6-8-18/h17-18H,3-13,15-16H2,1-2H3,(H,26,30)/t17-/m1/s1	IYNMURUXRWXKNZ-QGZVFWFLSA-N	326793	US9662327, Compound 378	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326793	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326793&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118765	384581745							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642570	CCCC(=O)N1CCN(C[C@H]1C)c1nc(C2CCCCC2)c2COCCc2c1C#N	InChI=1S/C24H34N4O2/c1-3-7-22(29)28-12-11-27(15-17(28)2)24-20(14-25)19-10-13-30-16-21(19)23(26-24)18-8-5-4-6-9-18/h17-18H,3-13,15-16H2,1-2H3/t17-/m1/s1	PXURFPBUPXQVNN-QGZVFWFLSA-N	326794	US9662327, Compound 379	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326794	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326794&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118973	384581746							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642571	CC(C)[C@@H]1CN(CCN1C(O)Cn1ccnc1C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H38N6O2/c1-17(2)23-14-32(10-11-33(23)24(34)15-31-9-8-29-18(31)3)26-21(13-28)20-12-27(4,5)35-16-22(20)25(30-26)19-6-7-19/h8-9,17,19,23-24,34H,6-7,10-12,14-16H2,1-5H3/t23-,24?/m0/s1	YITSCIAWBBTSIK-UXMRNZNESA-N	326795	US9662327, Compound 380	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326795	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326795&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295180	384581747							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642572	CCCOCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H38N4O3/c1-6-11-32-16-23(31)30-10-9-29(14-22(30)17(2)3)25-20(13-27)19-12-26(4,5)33-15-21(19)24(28-25)18-7-8-18/h17-18,22H,6-12,14-16H2,1-5H3/t22-/m0/s1	PXOQYIVKHGNCST-QFIPXVFZSA-N	326796	US9662327, Compound 381	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326796	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326796&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166708	384581748							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642573	CC(C)[C@@H]1CN(CCN1C(=O)CC1CC1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H36N4O2/c1-16(2)22-14-29(9-10-30(22)23(31)11-17-5-6-17)25-20(13-27)19-12-26(3,4)32-15-21(19)24(28-25)18-7-8-18/h16-18,22H,5-12,14-15H2,1-4H3/t22-/m0/s1	AJCZHSZVSDGYFW-QFIPXVFZSA-N	326797	US9662327, Compound 382	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326797	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326797&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283379	384581749							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642574	CCCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H36N4O2/c1-6-7-22(30)29-11-10-28(14-21(29)16(2)3)24-19(13-26)18-12-25(4,5)31-15-20(18)23(27-24)17-8-9-17/h16-17,21H,6-12,14-15H2,1-5H3/t21-/m0/s1	MNMYUUKZIYHHCN-NRFANRHFSA-N	326798	US9662327, Compound 383::US9662327, Compound 437::US9662327, Compound 438	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326798	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326798&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71136884	384581750							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642575	CC(C)[C@@H]1CN(CCN1C(=O)COc1cccc(F)c1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C29H35FN4O3/c1-18(2)25-15-33(10-11-34(25)26(35)17-36-21-7-5-6-20(30)12-21)28-23(14-31)22-13-29(3,4)37-16-24(22)27(32-28)19-8-9-19/h5-7,12,18-19,25H,8-11,13,15-17H2,1-4H3/t25-/m0/s1	SGVSJXKOTFQPBD-VWLOTQADSA-N	326799	US9662327, Compound 384	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326799	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326799&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295182	384581751							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642576	COCCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(c2COC(C)(C)Cc2c1C#N)C(C)(C)C	InChI=1S/C26H40N4O3/c1-17(2)21-15-29(10-11-30(21)22(31)9-12-32-8)24-19(14-27)18-13-26(6,7)33-16-20(18)23(28-24)25(3,4)5/h17,21H,9-13,15-16H2,1-8H3/t21-/m0/s1	FKAPZKITZLOSIB-NRFANRHFSA-N	326800	US9662327, Compound 385	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326800	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326800&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295184	384581752							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642577	CC(C)[C@@H]1CN(CCN1C(=O)c1ccoc1)c1nc(c2COC(C)(C)Cc2c1C#N)C1(C)CC1	InChI=1S/C27H34N4O3/c1-17(2)22-14-30(9-10-31(22)25(32)18-6-11-33-15-18)24-20(13-28)19-12-26(3,4)34-16-21(19)23(29-24)27(5)7-8-27/h6,11,15,17,22H,7-10,12,14,16H2,1-5H3/t22-/m0/s1	ZTVFUZRVLNUZPG-QFIPXVFZSA-N	326801	US9662327, Compound 386	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326801	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326801&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295183	384581753							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642578	COC(=O)C1CN(CCN1C(=O)c1ccoc1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H28N4O5/c1-25(2)10-17-18(11-26)22(27-21(15-4-5-15)19(17)14-34-25)28-7-8-29(20(12-28)24(31)32-3)23(30)16-6-9-33-13-16/h6,9,13,15,20H,4-5,7-8,10,12,14H2,1-3H3	UBRWJMBUAGPERW-UHFFFAOYSA-N	326802	US9662327, Compound 387	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326802	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326802&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295185	384581754							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642579	COCCC(=O)N1CCN(CC1C(=O)OC)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H32N4O5/c1-24(2)11-16-17(12-25)22(26-21(15-5-6-15)18(16)14-33-24)27-8-9-28(20(29)7-10-31-3)19(13-27)23(30)32-4/h15,19H,5-11,13-14H2,1-4H3	PGKMYVCUNGTXLR-UHFFFAOYSA-N	326803	US9662327, Compound 388	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326803	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326803&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166709	384581755							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642580	COCCC(=O)N1CCN(C[C@@H]1CC(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H38N4O3/c1-17(2)12-19-15-29(9-10-30(19)23(31)8-11-32-5)25-21(14-27)20-13-26(3,4)33-16-22(20)24(28-25)18-6-7-18/h17-19H,6-13,15-16H2,1-5H3/t19-/m0/s1	JEAKWCAESZBOCL-IBGZPJMESA-N	326804	US9662327, Compound 389	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326804	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326804&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295187	384581756							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642581	CC(C)[C@@H]1CN(CCN1C(=O)COCC1CC1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H38N4O3/c1-17(2)23-13-30(9-10-31(23)24(32)16-33-14-18-5-6-18)26-21(12-28)20-11-27(3,4)34-15-22(20)25(29-26)19-7-8-19/h17-19,23H,5-11,13-16H2,1-4H3/t23-/m0/s1	JDHODZMVGFEKNH-QHCPKHFHSA-N	326805	US9662327, Compound 390	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326805	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326805&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295188	384581757							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642582	CCS(O)(O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C23H36N4O3S/c1-6-31(28,29)27-10-9-26(13-20(27)15(2)3)22-18(12-24)17-11-23(4,5)30-14-19(17)21(25-22)16-7-8-16/h15-16,20,28-29H,6-11,13-14H2,1-5H3/t20-/m0/s1	RZTJMXVHCWYFNX-FQEVSTJZSA-N	326806	US9662327, Compound 391	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326806	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326806&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123407125	384581758							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642583	CCOC(=O)CCNC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C27H41N5O4/c1-6-35-23(33)9-10-29-26(34)32-12-11-31(15-22(32)17(2)3)25-20(14-28)19-13-27(4,5)36-16-21(19)24(30-25)18-7-8-18/h14,17-18,22,28H,6-13,15-16H2,1-5H3,(H,29,34)/t22-/m0/s1	XKCZTLFOPLMWOH-QFIPXVFZSA-N	326807	US9662327, Compound 392	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326807	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326807&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166710	384581759							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642584	COC(=O)C1CN(CCN1C(=O)c1ccoc1)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H30N4O5/c1-15(2)21-19-14-34-25(3,4)10-17(19)18(11-26)22(27-21)28-7-8-29(20(12-28)24(31)32-5)23(30)16-6-9-33-13-16/h6,9,13,15,20H,7-8,10,12,14H2,1-5H3	KOVBVRRBGYZJIQ-UHFFFAOYSA-N	326808	US9662327, Compound 393	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326808	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326808&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119354	384581760							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642585	COC(=O)C1CN(CCN1C(=O)c1ccoc1C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H30N4O5/c1-15-17(7-10-34-15)24(31)30-9-8-29(13-21(30)25(32)33-4)23-19(12-27)18-11-26(2,3)35-14-20(18)22(28-23)16-5-6-16/h7,10,16,21H,5-6,8-9,11,13-14H2,1-4H3	JQXHUJABRVLCMD-UHFFFAOYSA-N	326809	US9662327, Compound 394	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326809	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326809&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282758	384581761							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642586	COCCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CCC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H38N4O3/c1-17(2)22-15-29(10-11-30(22)23(31)9-12-32-5)25-20(14-27)19-13-26(3,4)33-16-21(19)24(28-25)18-7-6-8-18/h17-18,22H,6-13,15-16H2,1-5H3/t22-/m0/s1	PVXCSJIGHDCQRQ-QFIPXVFZSA-N	326810	US9662327, Compound 395	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326810	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326810&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282784	384581762							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642587	CC(C)[C@@H]1CN(CCN1C(=O)C1CC1)c1nc(C2CCC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H36N4O2/c1-16(2)22-14-29(10-11-30(22)25(31)18-8-9-18)24-20(13-27)19-12-26(3,4)32-15-21(19)23(28-24)17-6-5-7-17/h16-18,22H,5-12,14-15H2,1-4H3/t22-/m0/s1	GXMQXAYQFNHDRJ-QFIPXVFZSA-N	326811	US9662327, Compound 396	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326811	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326811&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283345	384581763							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642588	COC(=O)CN1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H34N4O3/c1-15(2)20-12-28(9-8-27(20)13-21(29)30-5)23-18(11-25)17-10-24(3,4)31-14-19(17)22(26-23)16-6-7-16/h15-16,20H,6-10,12-14H2,1-5H3/t20-/m0/s1	BARIQFBOVWJXGL-FQEVSTJZSA-N	326812	US9662327, Compound 397	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326812	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326812&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119186	384581764							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642589	CC(C)[C@@H]1CN(CCN1C(=O)NC1CC1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H35N5O2/c1-15(2)21-13-29(9-10-30(21)24(31)27-17-7-8-17)23-19(12-26)18-11-25(3,4)32-14-20(18)22(28-23)16-5-6-16/h15-17,21H,5-11,13-14H2,1-4H3,(H,27,31)/t21-/m0/s1	YBLRGZXHNGYTDW-NRFANRHFSA-N	326813	US9662327, Compound 398	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326813	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326813&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282710	384581765							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642590	CC(C)[C@@H]1CN(CCN1C(=O)COc1cccnc1)c1nc(C2CC2)c2COC(C)Cc2c1C#N	InChI=1S/C27H33N5O3/c1-17(2)24-14-31(9-10-32(24)25(33)16-35-20-5-4-8-29-13-20)27-22(12-28)21-11-18(3)34-15-23(21)26(30-27)19-6-7-19/h4-5,8,13,17-19,24H,6-7,9-11,14-16H2,1-3H3/t18?,24-/m0/s1	ARPJHBMRGQBFQT-LUTIACGYSA-N	326814	US9662327, Compound 399	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326814	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326814&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166711	384581766							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642591	CC(C)[C@@H]1CN(CCN1C(=O)Cn1ccc(C)n1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H36N6O2/c1-17(2)23-14-31(10-11-33(23)24(34)15-32-9-8-18(3)30-32)26-21(13-28)20-12-27(4,5)35-16-22(20)25(29-26)19-6-7-19/h8-9,17,19,23H,6-7,10-12,14-16H2,1-5H3/t23-/m0/s1	PCCWZYXXWAOWBM-QHCPKHFHSA-N	326815	US9662327, Compound 400	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326815	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326815&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282848	384581767							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642592	CC(C)[C@@H]1CN(CCN1C(=O)Cn1cc(C)cn1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H36N6O2/c1-17(2)23-14-31(8-9-33(23)24(34)15-32-13-18(3)12-29-32)26-21(11-28)20-10-27(4,5)35-16-22(20)25(30-26)19-6-7-19/h12-13,17,19,23H,6-10,14-16H2,1-5H3/t23-/m0/s1	RSHOPEHMGQUWHM-QHCPKHFHSA-N	326816	US9662327, Compound 401	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326816	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326816&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282860	384581768							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642593	COCC1CN(CCN1C(=O)c1ccoc1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C25H32N4O4/c1-25(2)10-19-20(11-26)23(27-22(16-4-5-16)21(19)15-33-25)28-7-8-29(18(12-28)14-31-3)24(30)17-6-9-32-13-17/h6,9,11,13,16,18,26H,4-5,7-8,10,12,14-15H2,1-3H3	NQTSTCUCZOWQKM-UHFFFAOYSA-N	326817	US9662327, Compound 402	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326817	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326817&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295193	384581769							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642594	COCCC(=O)N1CCN(CC1COC)c1nc(C2CC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C24H36N4O4/c1-24(2)11-18-19(12-25)23(26-22(16-5-6-16)20(18)15-32-24)27-8-9-28(17(13-27)14-31-4)21(29)7-10-30-3/h12,16-17,25H,5-11,13-15H2,1-4H3	XCUJHAIGOWMBAA-UHFFFAOYSA-N	326818	US9662327, Compound 403	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326818	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326818&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295194	384581770							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642595	CC(C)[C@@H]1CN(CCN1C(=O)COCc1ccco1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C28H38N4O4/c1-18(2)24-14-31(9-10-32(24)25(33)17-34-15-20-6-5-11-35-20)27-22(13-29)21-12-28(3,4)36-16-23(21)26(30-27)19-7-8-19/h5-6,11,13,18-19,24,29H,7-10,12,14-17H2,1-4H3/t24-/m0/s1	GLWFMUUSZFGWDO-DEOSSOPVSA-N	326819	US9662327, Compound 404	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326819	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326819&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295195	384581771							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642596	CC(C)[C@@H]1CN(CCN1C(=O)Cn1ncc2ccccc12)c1nc(C2CC2)c2COC(C)Cc2c1C#N	InChI=1S/C29H34N6O2/c1-18(2)26-15-33(10-11-34(26)27(36)16-35-25-7-5-4-6-21(25)14-31-35)29-23(13-30)22-12-19(3)37-17-24(22)28(32-29)20-8-9-20/h4-7,14,18-20,26H,8-12,15-17H2,1-3H3/t19?,26-/m0/s1	NQBWAEROKXQLCI-SYCQMTRVSA-N	326820	US9662327, Compound 405	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326820	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326820&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166712	384581772							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642597	CC(C)[C@@H]1CN(CCN1C(=O)Cn1ccc2ccccc12)c1nc(C(C)C)c2COC(C)Cc2c1C#N	InChI=1S/C30H37N5O2/c1-19(2)27-16-34(12-13-35(27)28(36)17-33-11-10-22-8-6-7-9-26(22)33)30-24(15-31)23-14-21(5)37-18-25(23)29(32-30)20(3)4/h6-11,19-21,27H,12-14,16-18H2,1-5H3/t21?,27-/m0/s1	FUJBVWKAPKDDSY-YQAGWJQESA-N	326821	US9662327, Compound 406	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326821	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326821&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			129166713	384581773							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642598	CC(C)[C@@H]1CN(CCN1C(=O)Cn1nccn1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C25H35N7O2/c1-16(2)21-13-30(9-10-31(21)22(33)14-32-27-7-8-28-32)24-19(12-26)18-11-25(3,4)34-15-20(18)23(29-24)17-5-6-17/h7-8,12,16-17,21,26H,5-6,9-11,13-15H2,1-4H3/t21-/m0/s1	BHESQRHEEVTYBT-NRFANRHFSA-N	326822	US9662327, Compound 407	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326822	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326822&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295197	384581774							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642599	CC(C)[C@@H]1CN(CCN1C(=O)Cn1ccnn1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C=N	InChI=1S/C25H35N7O2/c1-16(2)21-13-30(9-10-32(21)22(33)14-31-8-7-27-29-31)24-19(12-26)18-11-25(3,4)34-15-20(18)23(28-24)17-5-6-17/h7-8,12,16-17,21,26H,5-6,9-11,13-15H2,1-4H3/t21-/m0/s1	JLQLXFVABDJJOX-NRFANRHFSA-N	326823	US9662327, Compound 408	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326823	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326823&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295199	384581775							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642600	COC(=O)CC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H34N4O4/c1-15(2)20-13-28(8-9-29(20)21(30)10-22(31)32-5)24-18(12-26)17-11-25(3,4)33-14-19(17)23(27-24)16-6-7-16/h15-16,20H,6-11,13-14H2,1-5H3/t20-/m0/s1	SGFIRUIMDTULEB-FQEVSTJZSA-N	326824	US9662327, Compound 409	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326824	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326824&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71477441	384581776							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642601	CCOC(=O)[C@H]1CN(CCN1C(=O)c1ccoc1)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H32N4O5/c1-6-34-25(32)21-13-29(8-9-30(21)24(31)17-7-10-33-14-17)23-19(12-27)18-11-26(4,5)35-15-20(18)22(28-23)16(2)3/h7,10,14,16,21H,6,8-9,11,13,15H2,1-5H3/t21-/m1/s1	SFNAXYZMNWMVSL-OAQYLSRUSA-N	326825	US9662327, Compound 410	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326825	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326825&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295200	384581777							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642602	CCOC(=O)[C@@H]1CN(CCN1C(=O)c1ccoc1)c1nc(C(C)C)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H32N4O5/c1-6-34-25(32)21-13-29(8-9-30(21)24(31)17-7-10-33-14-17)23-19(12-27)18-11-26(4,5)35-15-20(18)22(28-23)16(2)3/h7,10,14,16,21H,6,8-9,11,13,15H2,1-5H3/t21-/m0/s1	SFNAXYZMNWMVSL-NRFANRHFSA-N	326826	US9662327, Compound 411	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326826	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326826&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295201	384581778							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642603	COC(=O)CCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H36N4O4/c1-16(2)21-14-29(10-11-30(21)22(31)8-9-23(32)33-5)25-19(13-27)18-12-26(3,4)34-15-20(18)24(28-25)17-6-7-17/h16-17,21H,6-12,14-15H2,1-5H3/t21-/m0/s1	JPRYCVUCBMCXFD-NRFANRHFSA-N	326827	US9662327, Compound 412::US9662327, Compound 450	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326827	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326827&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119113	384581779							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642604	CCc1nc(N2CCN([C@@H](C2)C(C)C)C(=O)CCOC)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C24H36N4O3/c1-7-20-19-15-31-24(4,5)12-17(19)18(13-25)23(26-20)27-9-10-28(21(14-27)16(2)3)22(29)8-11-30-6/h16,21H,7-12,14-15H2,1-6H3/t21-/m0/s1	XUMMKWJIMLIBAW-NRFANRHFSA-N	326828	US9662327, Compound 413	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326828	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326828&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283357	384581780							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642605	CCc1nc(N2CCN([C@@H](C2)C(C)C)C(=O)c2ccoc2)c(C#N)c2CC(C)(C)OCc12	InChI=1S/C25H32N4O3/c1-6-21-20-15-32-25(4,5)11-18(20)19(12-26)23(27-21)28-8-9-29(22(13-28)16(2)3)24(30)17-7-10-31-14-17/h7,10,14,16,22H,6,8-9,11,13,15H2,1-5H3/t22-/m0/s1	LLERVXSDQSOJKQ-QFIPXVFZSA-N	326829	US9662327, Compound 414	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326829	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326829&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282911	384581781							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642606	CC(C)[C@@H]1CN(CCN1C(=O)Cn1cc(Br)cn1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H33BrN6O2/c1-16(2)22-13-31(7-8-33(22)23(34)14-32-12-18(27)11-29-32)25-20(10-28)19-9-26(3,4)35-15-21(19)24(30-25)17-5-6-17/h11-12,16-17,22H,5-9,13-15H2,1-4H3/t22-/m0/s1	VFXPDTRAAHRVJQ-QFIPXVFZSA-N	326830	US9662327, Compound 415	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326830	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326830&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282876	384581782							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642607	CC(C)[C@@H]1CN(CCN1C(=O)CCC(O)=O)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H34N4O4/c1-15(2)20-13-28(9-10-29(20)21(30)7-8-22(31)32)24-18(12-26)17-11-25(3,4)33-14-19(17)23(27-24)16-5-6-16/h15-16,20H,5-11,13-14H2,1-4H3,(H,31,32)/t20-/m0/s1	AUGFFMBAAGXFDU-FQEVSTJZSA-N	326831	US9662327, Compound 416	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326831	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326831&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118785	384581783							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642608	CC(C)[C@@H]1CN(CCN1C(=O)COC1CCOC1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H38N4O4/c1-17(2)23-13-30(8-9-31(23)24(32)16-34-19-7-10-33-14-19)26-21(12-28)20-11-27(3,4)35-15-22(20)25(29-26)18-5-6-18/h17-19,23H,5-11,13-16H2,1-4H3/t19?,23-/m0/s1	ZATRRZCLKDXHRD-BVHINDKJSA-N	326832	US9662327, Compound 417	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326832	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326832&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283292	384581784							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642609	CC(C)[C@@H]1CN(CCN1C(=O)CC(O)=O)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H32N4O4/c1-14(2)19-12-27(7-8-28(19)20(29)9-21(30)31)23-17(11-25)16-10-24(3,4)32-13-18(16)22(26-23)15-5-6-15/h14-15,19H,5-10,12-13H2,1-4H3,(H,30,31)/t19-/m0/s1	BYFXZYBMSGMDKA-IBGZPJMESA-N	326833	US9662327, Compound 418	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326833	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326833&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86727217	384581785					C01656		1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642610	CC(C)[C@@H]1CN(CCN1C(=O)C(C)(C)COC(C)=O)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C28H40N4O4/c1-17(2)23-14-31(10-11-32(23)26(34)27(4,5)16-35-18(3)33)25-21(13-29)20-12-28(6,7)36-15-22(20)24(30-25)19-8-9-19/h17,19,23H,8-12,14-16H2,1-7H3/t23-/m0/s1	KKWFKQHLZHUKNJ-QHCPKHFHSA-N	326834	US9662327, Compound 419	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326834	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326834&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282989	384581786							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642611	CCOC(=O)C1CN(CCN1C(=O)Cc1cccs1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H32N4O4S/c1-4-34-26(33)22-15-30(9-10-31(22)23(32)12-18-6-5-11-36-18)25-20(14-28)19-13-27(2,3)35-16-21(19)24(29-25)17-7-8-17/h5-6,11,17,22H,4,7-10,12-13,15-16H2,1-3H3	VIFAQYSGZHLYTB-UHFFFAOYSA-N	326835	US9662327, Compound 421	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326835	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326835&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118857	384581787							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642612	CC(C)[C@@H]1CN(CCN1C(=O)CC(C)=O)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H34N4O3/c1-15(2)21-13-28(8-9-29(21)22(31)10-16(3)30)24-19(12-26)18-11-25(4,5)32-14-20(18)23(27-24)17-6-7-17/h15,17,21H,6-11,13-14H2,1-5H3/t21-/m0/s1	UCDQUXKHYFVCGW-NRFANRHFSA-N	326836	US9662327, Compound 422	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326836	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326836&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89307477	384581788							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642613	CC(C)[C@@H]1CN(CCN1C(=O)CC(F)(F)F)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H31F3N4O2/c1-14(2)19-12-30(7-8-31(19)20(32)10-24(25,26)27)22-17(11-28)16-9-23(3,4)33-13-18(16)21(29-22)15-5-6-15/h14-15,19H,5-10,12-13H2,1-4H3/t19-/m0/s1	KZPZXNCKRBSHGT-IBGZPJMESA-N	326837	US9662327, Compound 423::US9662327, Compound 477	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326837	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326837&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119242	384581789							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642614	COCCCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H38N4O3/c1-17(2)22-15-29(10-11-30(22)23(31)7-6-12-32-5)25-20(14-27)19-13-26(3,4)33-16-21(19)24(28-25)18-8-9-18/h17-18,22H,6-13,15-16H2,1-5H3/t22-/m0/s1	HDSOPTUMQZUZNT-QFIPXVFZSA-N	326838	US9662327, Compound 424	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326838	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326838&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118637	384581790							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642615	COCCC(=O)N1CCN(CC1C1CC1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H34N4O3/c1-25(2)12-18-19(13-26)24(27-23(17-6-7-17)20(18)15-32-25)28-9-10-29(22(30)8-11-31-3)21(14-28)16-4-5-16/h16-17,21H,4-12,14-15H2,1-3H3	GNDMXEAGAZOBEM-UHFFFAOYSA-N	326839	US9662327, Compound 425	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326839	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326839&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119110	384581791							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642616	CC1(C)Cc2c(CO1)c(nc(N1CCN(C(C1)C1CC1)C(=O)c1ccoc1)c2C#N)C1CC1	InChI=1S/C26H30N4O3/c1-26(2)11-19-20(12-27)24(28-23(17-5-6-17)21(19)15-33-26)29-8-9-30(22(13-29)16-3-4-16)25(31)18-7-10-32-14-18/h7,10,14,16-17,22H,3-6,8-9,11,13,15H2,1-2H3	JIXSBEMKVGMQGB-UHFFFAOYSA-N	326840	US9662327, Compound 426	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326840	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326840&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118928	384581792							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642617	CC(C)[C@@H]1CN(CCN1C(=O)c1ccon1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H31N5O3/c1-15(2)21-13-29(8-9-30(21)24(31)20-7-10-33-28-20)23-18(12-26)17-11-25(3,4)32-14-19(17)22(27-23)16-5-6-16/h7,10,15-16,21H,5-6,8-9,11,13-14H2,1-4H3/t21-/m0/s1	LUYDIXGBGGEOEO-NRFANRHFSA-N	326841	US9662327, Compound 427	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326841	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326841&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119163	384581793							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642618	CC(C)[C@@H]1CN(CCN1C(=O)CCC(C)=O)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H36N4O3/c1-16(2)22-14-29(10-11-30(22)23(32)9-6-17(3)31)25-20(13-27)19-12-26(4,5)33-15-21(19)24(28-25)18-7-8-18/h16,18,22H,6-12,14-15H2,1-5H3/t22-/m0/s1	OTASZJXTTONKRG-QFIPXVFZSA-N	326842	US9662327, Compound 428	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326842	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326842&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119131	384581794							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642619	CC(C)[C@@H]1CN(CCN1C(=O)CCO)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H34N4O3/c1-15(2)20-13-27(8-9-28(20)21(30)7-10-29)23-18(12-25)17-11-24(3,4)31-14-19(17)22(26-23)16-5-6-16/h15-16,20,29H,5-11,13-14H2,1-4H3/t20-/m0/s1	LEGIFHSKFODEMO-FQEVSTJZSA-N	326843	US9662327, Compound 429	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326843	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326843&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119218	384581795							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642620	CC1(C)Cc2c(CO1)c(nc(N1CCN(C(C1)C1CC1)C(=O)CC(F)(F)F)c2C#N)C1CC1	InChI=1S/C24H29F3N4O2/c1-23(2)9-16-17(11-28)22(29-21(15-5-6-15)18(16)13-33-23)30-7-8-31(19(12-30)14-3-4-14)20(32)10-24(25,26)27/h14-15,19H,3-10,12-13H2,1-2H3	AANLLHGDLJWDBB-UHFFFAOYSA-N	326844	US9662327, Compound 430	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326844	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326844&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118902	384581796							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642621	COC(=O)NCCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H37N5O4/c1-16(2)21-14-30(10-11-31(21)22(32)8-9-28-25(33)34-5)24-19(13-27)18-12-26(3,4)35-15-20(18)23(29-24)17-6-7-17/h16-17,21H,6-12,14-15H2,1-5H3,(H,28,33)/t21-/m0/s1	ZVURWMZOXZEBBE-NRFANRHFSA-N	326845	US9662327, Compound 431	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326845	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326845&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118630	384581797							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642622	COCCC(=O)N1CCN(C[C@H]1C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C23H32N4O3/c1-15-13-26(8-9-27(15)20(28)7-10-29-4)22-18(12-24)17-11-23(2,3)30-14-19(17)21(25-22)16-5-6-16/h15-16H,5-11,13-14H2,1-4H3/t15-/m1/s1	PQXMHIOYPWGJDU-OAHLLOKOSA-N	326846	US9662327, Compound 432	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326846	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326846&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119579	384581798							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642623	CC(O)CC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H36N4O3/c1-15(2)21-13-28(8-9-29(21)22(31)10-16(3)30)24-19(12-26)18-11-25(4,5)32-14-20(18)23(27-24)17-6-7-17/h15-17,21,30H,6-11,13-14H2,1-5H3/t16?,21-/m0/s1	PNPHQHWMLXYZSG-MRNPHLECSA-N	326847	US9662327, Compound 433	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326847	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326847&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119119	384581799							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642624	COCCC(=O)N1CCN(C[C@H]1C1CC1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H34N4O3/c1-25(2)12-18-19(13-26)24(27-23(17-6-7-17)20(18)15-32-25)28-9-10-29(22(30)8-11-31-3)21(14-28)16-4-5-16/h16-17,21H,4-12,14-15H2,1-3H3/t21-/m0/s1	GNDMXEAGAZOBEM-NRFANRHFSA-N	326848	US9662327, Compound 434	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326848	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326848&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119107	384581800							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642625	CC1(C)Cc2c(CO1)c(nc(N1CCN([C@@H](C1)C1CC1)C(=O)CC(F)(F)F)c2C#N)C1CC1	InChI=1S/C24H29F3N4O2/c1-23(2)9-16-17(11-28)22(29-21(15-5-6-15)18(16)13-33-23)30-7-8-31(19(12-30)14-3-4-14)20(32)10-24(25,26)27/h14-15,19H,3-10,12-13H2,1-2H3/t19-/m0/s1	AANLLHGDLJWDBB-IBGZPJMESA-N	326849	US9662327, Compound 435	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326849	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326849&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118901	384581801							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642626	CCCC(=O)N1CCN(C[C@@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H36N4O2/c1-6-7-22(30)29-11-10-28(14-21(29)16(2)3)24-19(13-26)18-12-25(4,5)31-15-20(18)23(27-24)17-8-9-17/h16-17,21H,6-12,14-15H2,1-5H3/t21-/m1/s1	MNMYUUKZIYHHCN-OAQYLSRUSA-N	326850	US9662327, Compound 436	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326850	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326850&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138404117	384581802							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642627	CCCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H36N4O2/c1-6-7-22(30)29-11-10-28(14-21(29)16(2)3)24-19(13-26)18-12-25(4,5)31-15-20(18)23(27-24)17-8-9-17/h16-17,21H,6-12,14-15H2,1-5H3/t21-/m0/s1	MNMYUUKZIYHHCN-NRFANRHFSA-N	326798	US9662327, Compound 383::US9662327, Compound 437::US9662327, Compound 438	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326798	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326798&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71136884	384581750							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642628	CCCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H36N4O2/c1-6-7-22(30)29-11-10-28(14-21(29)16(2)3)24-19(13-26)18-12-25(4,5)31-15-20(18)23(27-24)17-8-9-17/h16-17,21H,6-12,14-15H2,1-5H3/t21-/m0/s1	MNMYUUKZIYHHCN-NRFANRHFSA-N	326798	US9662327, Compound 383::US9662327, Compound 437::US9662327, Compound 438	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326798	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326798&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71136884	384581750							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642629	COC(=O)C(C)CCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C28H40N4O4/c1-17(2)23-15-31(11-12-32(23)24(33)10-7-18(3)27(34)35-6)26-21(14-29)20-13-28(4,5)36-16-22(20)25(30-26)19-8-9-19/h17-19,23H,7-13,15-16H2,1-6H3/t18?,23-/m0/s1	FCMVQVIPQGMSMT-IMMUGOHXSA-N	326853	US9662327, Compound 439	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326853	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326853&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119541	384581803							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642630	COC(=O)CC(=O)N1CCN(C[C@H]1C1CC1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H32N4O4/c1-25(2)11-17-18(12-26)24(27-23(16-6-7-16)19(17)14-33-25)28-8-9-29(20(13-28)15-4-5-15)21(30)10-22(31)32-3/h15-16,20H,4-11,13-14H2,1-3H3/t20-/m0/s1	SPFZAXOOCKXCJC-FQEVSTJZSA-N	326854	US9662327, Compound 440	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326854	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326854&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118966	384581804							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642631	COCCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H36N4O3/c1-16(2)21-14-28(9-10-29(21)22(30)8-11-31-5)24-19(13-26)18-12-25(3,4)32-15-20(18)23(27-24)17-6-7-17/h16-17,21H,6-12,14-15H2,1-5H3/t21-/m0/s1	ZRXFQKKZPXKAKJ-NRFANRHFSA-N	326855	US9662327, Compound 441::US9662327, Compound 444	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326855	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326855&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283133	384581805							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642632	CC(O)CC(=O)N1CCN(C[C@H]1C1CC1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H34N4O3/c1-15(30)10-22(31)29-9-8-28(13-21(29)16-4-5-16)24-19(12-26)18-11-25(2,3)32-14-20(18)23(27-24)17-6-7-17/h15-17,21,30H,4-11,13-14H2,1-3H3/t15?,21-/m0/s1	JRMPINDBYYAFCP-FXMQYSIJSA-N	326856	US9662327, Compound 442	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326856	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326856&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119457	384581806							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642633	CC(C)[C@@H]1CN(CCN1C(=O)CCCO)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H36N4O3/c1-16(2)21-14-28(9-10-29(21)22(31)6-5-11-30)24-19(13-26)18-12-25(3,4)32-15-20(18)23(27-24)17-7-8-17/h16-17,21,30H,5-12,14-15H2,1-4H3/t21-/m0/s1	CZSAKKSCCYLTBB-NRFANRHFSA-N	326857	US9662327, Compound 443	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326857	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326857&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119042	384581807							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642634	COCCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H36N4O3/c1-16(2)21-14-28(9-10-29(21)22(30)8-11-31-5)24-19(13-26)18-12-25(3,4)32-15-20(18)23(27-24)17-6-7-17/h16-17,21H,6-12,14-15H2,1-5H3/t21-/m0/s1	ZRXFQKKZPXKAKJ-NRFANRHFSA-N	326855	US9662327, Compound 441::US9662327, Compound 444	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326855	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326855&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283133	384581805							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642635	CSCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H34N4O2S/c1-15(2)20-12-27(8-9-28(20)21(29)14-31-5)23-18(11-25)17-10-24(3,4)30-13-19(17)22(26-23)16-6-7-16/h15-16,20H,6-10,12-14H2,1-5H3/t20-/m0/s1	WQQKJCFNZBHKCY-FQEVSTJZSA-N	326859	US9662327, Compound 445	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326859	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326859&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119031	384581808							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642636	CC(C)[C@@H]1CN(CCN1C(=O)CS(C)(=O)=O)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H34N4O4S/c1-15(2)20-12-27(8-9-28(20)21(29)14-33(5,30)31)23-18(11-25)17-10-24(3,4)32-13-19(17)22(26-23)16-6-7-16/h15-16,20H,6-10,12-14H2,1-5H3/t20-/m0/s1	UYNLWBPYQPZNMR-FQEVSTJZSA-N	326860	US9662327, Compound 446	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326860	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326860&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119497	384581809							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642637	CC(C)[C@@H]1CN(CCN1C(=O)CCc1ccco1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C28H36N4O3/c1-18(2)24-16-31(11-12-32(24)25(33)10-9-20-6-5-13-34-20)27-22(15-29)21-14-28(3,4)35-17-23(21)26(30-27)19-7-8-19/h5-6,13,18-19,24H,7-12,14,16-17H2,1-4H3/t24-/m0/s1	DOZLCSNSHSORHW-DEOSSOPVSA-N	326861	US9662327, Compound 447	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326861	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326861&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118968	384581810							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642638	CC(C)[C@@H]1CN(CCN1C(=O)CCc1nnco1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H34N6O3/c1-16(2)21-13-31(9-10-32(21)23(33)8-7-22-30-28-15-34-22)25-19(12-27)18-11-26(3,4)35-14-20(18)24(29-25)17-5-6-17/h15-17,21H,5-11,13-14H2,1-4H3/t21-/m0/s1	FQWWKNYEYCRVTO-NRFANRHFSA-N	326862	US9662327, Compound 448	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326862	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326862&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119489	384581811							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642639	COC(=O)CCC(=O)N1CCN(C[C@@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H36N4O4/c1-16(2)21-14-29(10-11-30(21)22(31)8-9-23(32)33-5)25-19(13-27)18-12-26(3,4)34-15-20(18)24(28-25)17-6-7-17/h16-17,21H,6-12,14-15H2,1-5H3/t21-/m1/s1	JPRYCVUCBMCXFD-OAQYLSRUSA-N	326863	US9662327, Compound 449	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326863	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326863&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138404118	384581812							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642640	COC(=O)CCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H36N4O4/c1-16(2)21-14-29(10-11-30(21)22(31)8-9-23(32)33-5)25-19(13-27)18-12-26(3,4)34-15-20(18)24(28-25)17-6-7-17/h16-17,21H,6-12,14-15H2,1-5H3/t21-/m0/s1	JPRYCVUCBMCXFD-NRFANRHFSA-N	326827	US9662327, Compound 412::US9662327, Compound 450	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326827	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326827&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119113	384581779							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642641	CC(C)[C@H]1CN(CCN1C(=O)CC(F)(F)F)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H31F3N4O2/c1-14(2)19-12-30(7-8-31(19)20(32)10-24(25,26)27)22-17(11-28)16-9-23(3,4)33-13-18(16)21(29-22)15-5-6-15/h14-15,19H,5-10,12-13H2,1-4H3/t19-/m1/s1	KZPZXNCKRBSHGT-LJQANCHMSA-N	326865	US9662327, Compound 451	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326865	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326865&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			138404119	384581813							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642642	CC(C)C1CN(CCN1C(=O)CC(F)(F)F)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H31F3N4O2/c1-14(2)19-12-30(7-8-31(19)20(32)10-24(25,26)27)22-17(11-28)16-9-23(3,4)33-13-18(16)21(29-22)15-5-6-15/h14-15,19H,5-10,12-13H2,1-4H3	KZPZXNCKRBSHGT-UHFFFAOYSA-N	326866	US9662327, Compound 452::US9662327, Compound 476	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326866	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326866&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119244	384581814							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642643	CC(C)[C@@H]1CN(CCN1C(=O)CS(C)=O)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H34N4O3S/c1-15(2)20-12-27(8-9-28(20)21(29)14-32(5)30)23-18(11-25)17-10-24(3,4)31-13-19(17)22(26-23)16-6-7-16/h15-16,20H,6-10,12-14H2,1-5H3/t20-,32?/m0/s1	NKHLOSKGVFMLIB-QIFAOCFZSA-N	326867	US9662327, Compound 453	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326867	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326867&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118747	384581815							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642644	CC(C)[C@@H]1CN(CCN1C(=O)[C@@H]1C[C@H]1C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H36N4O2/c1-15(2)22-13-29(8-9-30(22)25(31)18-10-16(18)3)24-20(12-27)19-11-26(4,5)32-14-21(19)23(28-24)17-6-7-17/h15-18,22H,6-11,13-14H2,1-5H3/t16-,18-,22+/m1/s1	XOOBMBOUZNTTNJ-CDMIOBSGSA-N	326868	US9662327, Compound 454::US9662327, Compound 465	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326868	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326868&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71135515	384581816							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642645	CC(C)[C@@H]1CN(CCN1C(=O)Cc1nnco1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C25H32N6O3/c1-15(2)20-12-30(7-8-31(20)22(32)9-21-29-27-14-33-21)24-18(11-26)17-10-25(3,4)34-13-19(17)23(28-24)16-5-6-16/h14-16,20H,5-10,12-13H2,1-4H3/t20-/m0/s1	XGXCCQBFADBVID-FQEVSTJZSA-N	326869	US9662327, Compound 455	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326869	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326869&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119361	384581817							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642646	CCOC(=O)CCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H38N4O4/c1-6-34-24(33)10-9-23(32)31-12-11-30(15-22(31)17(2)3)26-20(14-28)19-13-27(4,5)35-16-21(19)25(29-26)18-7-8-18/h17-18,22H,6-13,15-16H2,1-5H3/t22-/m0/s1	VNDZFTBLJHFAQX-QFIPXVFZSA-N	326870	US9662327, Compound 456	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326870	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326870&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118791	384581818							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642647	CC(C)OC(=O)CCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C28H40N4O4/c1-17(2)23-15-31(11-12-32(23)24(33)9-10-25(34)36-18(3)4)27-21(14-29)20-13-28(5,6)35-16-22(20)26(30-27)19-7-8-19/h17-19,23H,7-13,15-16H2,1-6H3/t23-/m0/s1	NFUHADSDPPINTP-QHCPKHFHSA-N	326871	US9662327, Compound 457	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326871	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326871&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118963	384581819							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642648	CC(C)[C@@H]1CN(CCN1C(=O)CCC(=O)OCCO)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C27H38N4O5/c1-17(2)22-15-30(9-10-31(22)23(33)7-8-24(34)35-12-11-32)26-20(14-28)19-13-27(3,4)36-16-21(19)25(29-26)18-5-6-18/h17-18,22,32H,5-13,15-16H2,1-4H3/t22-/m0/s1	KFGNUPDUYKYVSP-QFIPXVFZSA-N	326872	US9662327, Compound 458	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326872	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326872&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119593	384581820							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642649	CCOCCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H38N4O3/c1-6-32-12-9-23(31)30-11-10-29(15-22(30)17(2)3)25-20(14-27)19-13-26(4,5)33-16-21(19)24(28-25)18-7-8-18/h17-18,22H,6-13,15-16H2,1-5H3/t22-/m0/s1	GOIMMGPCFWNAOY-QFIPXVFZSA-N	326873	US9662327, Compound 459	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326873	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326873&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118878	384581821							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642650	CC1(C)Cc2c(CO1)c(nc(N1CCN([C@@H](C1)C1CC1)C(=O)CCO)c2C#N)C1CC1	InChI=1S/C24H32N4O3/c1-24(2)11-17-18(12-25)23(26-22(16-5-6-16)19(17)14-31-24)27-8-9-28(21(30)7-10-29)20(13-27)15-3-4-15/h15-16,20,29H,3-11,13-14H2,1-2H3/t20-/m0/s1	XIAWTEKWHJTACC-FQEVSTJZSA-N	326874	US9662327, Compound 460	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326874	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326874&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118439	384581822							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642651	CC1(C)Cc2c(CO1)c(nc(N1CCN([C@@H](C1)C1CC1)C(=O)C1CC1)c2C#N)C1CC1	InChI=1S/C25H32N4O2/c1-25(2)11-18-19(12-26)23(27-22(16-5-6-16)20(18)14-31-25)28-9-10-29(24(30)17-7-8-17)21(13-28)15-3-4-15/h15-17,21H,3-11,13-14H2,1-2H3/t21-/m0/s1	MQXOATHGUZJPGB-NRFANRHFSA-N	326875	US9662327, Compound 461	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326875	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326875&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118895	384581823							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642652	CC(C)[C@@H]1CN(CCN1C(=O)C1C[C@H]1CO)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H36N4O3/c1-15(2)22-12-29(7-8-30(22)25(32)18-9-17(18)13-31)24-20(11-27)19-10-26(3,4)33-14-21(19)23(28-24)16-5-6-16/h15-18,22,31H,5-10,12-14H2,1-4H3/t17-,18?,22-/m0/s1	NBEMZEAEOMXEDQ-VGAYAIAPSA-N	326876	US9662327, Compound 462	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326876	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326876&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71137194	384581824							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642653	CC1(C)Cc2c(CO1)c(nc(N1CCN(C(C1)C(F)F)C(=O)C1CC1)c2C#N)C1CC1	InChI=1S/C23H28F2N4O2/c1-23(2)9-15-16(10-26)21(27-19(13-3-4-13)17(15)12-31-23)28-7-8-29(18(11-28)20(24)25)22(30)14-5-6-14/h13-14,18,20H,3-9,11-12H2,1-2H3	JIBRCGCWUFMAQU-UHFFFAOYSA-N	326877	US9662327, Compound 463	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326877	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326877&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119065	384581825							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642654	COCCC(=O)N1CCN(CC1C(F)F)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C23H30F2N4O3/c1-23(2)10-15-16(11-26)22(27-20(14-4-5-14)17(15)13-32-23)28-7-8-29(18(12-28)21(24)25)19(30)6-9-31-3/h14,18,21H,4-10,12-13H2,1-3H3	UBHAPBKUASWVCJ-UHFFFAOYSA-N	326878	US9662327, Compound 464	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326878	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326878&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295212	384581826							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642655	CC(C)[C@@H]1CN(CCN1C(=O)[C@@H]1C[C@H]1C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H36N4O2/c1-15(2)22-13-29(8-9-30(22)25(31)18-10-16(18)3)24-20(12-27)19-11-26(4,5)32-14-21(19)23(28-24)17-6-7-17/h15-18,22H,6-11,13-14H2,1-5H3/t16-,18-,22+/m1/s1	XOOBMBOUZNTTNJ-CDMIOBSGSA-N	326868	US9662327, Compound 454::US9662327, Compound 465	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326868	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326868&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71135515	384581816							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642656	CC1(C)Cc2c(CO1)c(nc(N1CCN([C@@H](C1)C1CC1)C(=O)CC1COC1)c2C#N)C1CC1	InChI=1S/C26H34N4O3/c1-26(2)10-19-20(11-27)25(28-24(18-5-6-18)21(19)15-33-26)29-7-8-30(22(12-29)17-3-4-17)23(31)9-16-13-32-14-16/h16-18,22H,3-10,12-15H2,1-2H3/t22-/m0/s1	SCYJPAWTIQJANL-QFIPXVFZSA-N	326880	US9662327, Compound 466	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326880	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326880&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118891	384581827							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642657	CCCCNC(=O)C(=O)CCC(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C30H43N5O4/c1-6-7-12-32-29(38)25(36)10-11-26(37)35-14-13-34(17-24(35)19(2)3)28-22(16-31)21-15-30(4,5)39-18-23(21)27(33-28)20-8-9-20/h19-20,24H,6-15,17-18H2,1-5H3,(H,32,38)/t24-/m0/s1	PVTCHIVQNCDORH-DEOSSOPVSA-N	326881	US9662327, Compound 467	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326881	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326881&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119016	384581828							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642658	CCOC(=O)[C@@H]1CN(CCN1C(C)=O)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C23H30N4O4/c1-5-30-22(29)19-12-26(8-9-27(19)14(2)28)21-17(11-24)16-10-23(3,4)31-13-18(16)20(25-21)15-6-7-15/h15,19H,5-10,12-13H2,1-4H3/t19-/m0/s1	KJIZZWSWFAETMK-IBGZPJMESA-N	326882	US9662327, Compound 468	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326882	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326882&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295213	384581829							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642659	COCCC(=O)N1CCN(CC1CC(F)(F)F)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H31F3N4O3/c1-23(2)11-17-18(12-28)22(29-21(15-4-5-15)19(17)14-34-23)30-7-8-31(20(32)6-9-33-3)16(13-30)10-24(25,26)27/h15-16H,4-11,13-14H2,1-3H3	OHGYWQSRPGEVDQ-UHFFFAOYSA-N	326883	US9662327, Compound 469	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326883	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326883&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119408	384581830							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642660	CC1(C)Cc2c(CO1)c(nc(N1CCN(C(CC(F)(F)F)C1)C(=O)CC(F)(F)F)c2C#N)C1CC1	InChI=1S/C23H26F6N4O2/c1-21(2)8-15-16(10-30)20(31-19(13-3-4-13)17(15)12-35-21)32-5-6-33(18(34)9-23(27,28)29)14(11-32)7-22(24,25)26/h13-14H,3-9,11-12H2,1-2H3	LHFNPUQZUZUTGC-UHFFFAOYSA-N	326884	US9662327, Compound 470	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326884	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326884&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89304756	384581831							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642661	CC1(C)Cc2c(CO1)c(nc(N1CCN(C(CC(F)(F)F)C1)C(=O)C1CC1)c2C#N)C1CC1	InChI=1S/C24H29F3N4O2/c1-23(2)10-17-18(11-28)21(29-20(14-3-4-14)19(17)13-33-23)30-7-8-31(22(32)15-5-6-15)16(12-30)9-24(25,26)27/h14-16H,3-10,12-13H2,1-2H3	HDPQLIHORKEGMI-UHFFFAOYSA-N	326885	US9662327, Compound 471	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326885	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326885&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119073	384581832							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642662	COC(=O)OC[C@@H]1CC1C(=O)N1CCN(C[C@H]1C(C)C)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C28H38N4O5/c1-16(2)23-13-31(8-9-32(23)26(33)19-10-18(19)14-36-27(34)35-5)25-21(12-29)20-11-28(3,4)37-15-22(20)24(30-25)17-6-7-17/h16-19,23H,6-11,13-15H2,1-5H3/t18-,19?,23-/m0/s1	GKHRIWHMLFULJB-SGCMCVRUSA-N	326886	US9662327, Compound 472	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326886	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326886&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295214	384581833							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642663	CC(C)[C@@H]1CN(CCN1C(=O)CC1CCO1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C26H36N4O3/c1-16(2)22-14-29(8-9-30(22)23(31)11-18-7-10-32-18)25-20(13-27)19-12-26(3,4)33-15-21(19)24(28-25)17-5-6-17/h16-18,22H,5-12,14-15H2,1-4H3/t18?,22-/m0/s1	XVBIKFQBCHKAHU-YSYXNDDBSA-N	326887	US9662327, Compound 473	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326887	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326887&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118910	384581834							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642664	CC1CN(CC(F)CN1C(=O)C1CC1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H31FN4O2/c1-14-10-28(11-17(25)12-29(14)23(30)16-6-7-16)22-19(9-26)18-8-24(2,3)31-13-20(18)21(27-22)15-4-5-15/h14-17H,4-8,10-13H2,1-3H3	CVJWXJIJXUXBJT-UHFFFAOYSA-N	326888	US9662327, Compound 474	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326888	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326888&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119459	384581835							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642665	CC1CCN(CCN1C(=O)C1CC1)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H32N4O2/c1-15-8-9-27(10-11-28(15)23(29)17-6-7-17)22-19(13-25)18-12-24(2,3)30-14-20(18)21(26-22)16-4-5-16/h15-17H,4-12,14H2,1-3H3	GWRQVJOANAVKMQ-UHFFFAOYSA-N	326889	US9662327, Compound 475	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326889	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326889&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118674	384581836							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642666	CC(C)C1CN(CCN1C(=O)CC(F)(F)F)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H31F3N4O2/c1-14(2)19-12-30(7-8-31(19)20(32)10-24(25,26)27)22-17(11-28)16-9-23(3,4)33-13-18(16)21(29-22)15-5-6-15/h14-15,19H,5-10,12-13H2,1-4H3	KZPZXNCKRBSHGT-UHFFFAOYSA-N	326866	US9662327, Compound 452::US9662327, Compound 476	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326866	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326866&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119244	384581814							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642667	CC(C)[C@@H]1CN(CCN1C(=O)CC(F)(F)F)c1nc(C2CC2)c2COC(C)(C)Cc2c1C#N	InChI=1S/C24H31F3N4O2/c1-14(2)19-12-30(7-8-31(19)20(32)10-24(25,26)27)22-17(11-28)16-9-23(3,4)33-13-18(16)21(29-22)15-5-6-15/h14-15,19H,5-10,12-13H2,1-4H3/t19-/m0/s1	KZPZXNCKRBSHGT-IBGZPJMESA-N	326837	US9662327, Compound 423::US9662327, Compound 477	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326837	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326837&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119242	384581789							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642668	COCCC(=O)N1CCN(C[C@H]1C1CC1)c1nc(C2CC2)c2CN(CCc2c1C#N)C(C)=O	InChI=1S/C25H33N5O3/c1-16(31)28-9-7-19-20(13-26)25(27-24(18-5-6-18)21(19)14-28)29-10-11-30(23(32)8-12-33-2)22(15-29)17-3-4-17/h17-18,22H,3-12,14-15H2,1-2H3/t22-/m0/s1	FOAZSNXFAMJTFP-QFIPXVFZSA-N	326892	US9662327, Compound 478	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326892	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326892&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118713	384581837							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642669	COCCC(=O)N1CCN(C[C@H]1C1CC1)c1nc(C2CC2)c2CN(CCc2c1C#N)S(C)(=O)=O	InChI=1S/C24H33N5O4S/c1-33-12-8-22(30)29-11-10-27(15-21(29)16-3-4-16)24-19(13-25)18-7-9-28(34(2,31)32)14-20(18)23(26-24)17-5-6-17/h16-17,21H,3-12,14-15H2,1-2H3/t21-/m0/s1	SQJLFYUURKQQPR-NRFANRHFSA-N	326893	US9662327, Compound 479	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326893	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326893&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119482	384581838							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642670	CC(=O)N1CCc2c(C1)c(nc(N1CCN([C@@H](C1)C1CC1)C(=O)C1CC1)c2C#N)C1CC1	InChI=1S/C25H31N5O2/c1-15(31)28-9-8-19-20(12-26)24(27-23(17-4-5-17)21(19)13-28)29-10-11-30(25(32)18-6-7-18)22(14-29)16-2-3-16/h16-18,22H,2-11,13-14H2,1H3/t22-/m0/s1	JHLKDDXJDDWULJ-QFIPXVFZSA-N	326894	US9662327, Compound 480	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326894	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326894&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118650	384581839							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642671	CS(=O)(=O)N1CCc2c(C1)c(nc(N1CCN([C@@H](C1)C1CC1)C(=O)C1CC1)c2C#N)C1CC1	InChI=1S/C24H31N5O3S/c1-33(31,32)28-9-8-18-19(12-25)23(26-22(16-4-5-16)20(18)13-28)27-10-11-29(24(30)17-6-7-17)21(14-27)15-2-3-15/h15-17,21H,2-11,13-14H2,1H3/t21-/m0/s1	DTOGJBQBUKGRIZ-NRFANRHFSA-N	326895	US9662327, Compound 481	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326895	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326895&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119444	384581840							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642672	C=CC(=O)N1CCc2c(nc(N3CCN([C@@H](C3)C3CC3)C(=O)C3CC3)c(C#N)c2C1)C1CC1	InChI=1S/C26H31N5O2/c1-2-23(32)29-10-9-19-21(14-29)20(13-27)25(28-24(19)17-5-6-17)30-11-12-31(26(33)18-7-8-18)22(15-30)16-3-4-16/h2,16-18,22H,1,3-12,14-15H2/t22-/m0/s1	WNHGRVIGXRJFDI-QFIPXVFZSA-N	326896	US9662327, Compound 482	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326896	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326896&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89288431	384581841							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642673	COCCC(=O)N1CCN(C[C@H]1C1CC1)c1nc(C2CC2)c2CCN(Cc2c1C#N)C(=O)C=C	InChI=1S/C26H33N5O3/c1-3-23(32)29-10-8-19-21(15-29)20(14-27)26(28-25(19)18-6-7-18)30-11-12-31(24(33)9-13-34-2)22(16-30)17-4-5-17/h3,17-18,22H,1,4-13,15-16H2,2H3/t22-/m0/s1	WQFAWMWBSUIJBT-QFIPXVFZSA-N	326897	US9662327, Compound 483	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326897	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326897&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89288101	384581842							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642674	COCCC(=O)N1CCN(C[C@H]1C1CC1)c1nc(C2CC2)c2CN(CCO)CCc2c1C#N	InChI=1S/C25H35N5O3/c1-33-13-7-23(32)30-10-9-29(16-22(30)17-2-3-17)25-20(14-26)19-6-8-28(11-12-31)15-21(19)24(27-25)18-4-5-18/h17-18,22,31H,2-13,15-16H2,1H3/t22-/m0/s1	JGSAATCBSUWOQF-QFIPXVFZSA-N	326898	US9662327, Compound 484	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326898	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326898&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282585	384581843							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642675	COCCC(=O)N1CCN(C[C@H]1C1CC1)c1nc(C2CC2)c2CN(CCc2c1C#N)C(=O)C=C	InChI=1S/C26H33N5O3/c1-3-23(32)29-10-8-19-20(14-27)26(28-25(18-6-7-18)21(19)15-29)30-11-12-31(24(33)9-13-34-2)22(16-30)17-4-5-17/h3,17-18,22H,1,4-13,15-16H2,2H3/t22-/m0/s1	UMGNQHCIUZYMAS-QFIPXVFZSA-N	326899	US9662327, Compound 485	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326899	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326899&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86727227	384581844							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642676	COCCC(=O)N1CCN(C[C@H]1C1CC1)c1nc(C2CC2)c2CCN(Cc2c1C#N)C(=O)C#C	InChI=1S/C26H31N5O3/c1-3-23(32)29-10-8-19-21(15-29)20(14-27)26(28-25(19)18-6-7-18)30-11-12-31(24(33)9-13-34-2)22(16-30)17-4-5-17/h1,17-18,22H,4-13,15-16H2,2H3/t22-/m0/s1	ACOVUVSSKJZNLR-QFIPXVFZSA-N	326900	US9662327, Compound 486	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326900	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326900&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282740	384581845							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642677	COCCC(=O)N1CCN(C[C@H]1C1CC1)c1nc(C2CC2)c2CCN(Cc2c1C#N)S(C)(=O)=O	InChI=1S/C24H33N5O4S/c1-33-12-8-22(30)29-11-10-27(15-21(29)16-3-4-16)24-19(13-25)20-14-28(34(2,31)32)9-7-18(20)23(26-24)17-5-6-17/h16-17,21H,3-12,14-15H2,1-2H3/t21-/m0/s1	TWHYIWMZUILDHE-NRFANRHFSA-N	326901	US9662327, Compound 487	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326901	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326901&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282986	384581846							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642678	COCCC(=O)N1CCN(C[C@H]1C1CC1)c1nc(C2CC2)c2CN(CCc2c1C#N)C(=O)C#C	InChI=1S/C26H31N5O3/c1-3-23(32)29-10-8-19-20(14-27)26(28-25(18-6-7-18)21(19)15-29)30-11-12-31(24(33)9-13-34-2)22(16-30)17-4-5-17/h1,17-18,22H,4-13,15-16H2,2H3/t22-/m0/s1	OFHCMQWJSSPENF-QFIPXVFZSA-N	326902	US9662327, Compound 488	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326902	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326902&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89288566	384581847							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642679	C=CC(=O)N1CCc2c(C1)c(nc(N1CCN([C@@H](C1)C1CC1)C(=O)C1CC1)c2C#N)C1CC1	InChI=1S/C26H31N5O2/c1-2-23(32)29-10-9-19-20(13-27)25(28-24(17-5-6-17)21(19)14-29)30-11-12-31(26(33)18-7-8-18)22(15-30)16-3-4-16/h2,16-18,22H,1,3-12,14-15H2/t22-/m0/s1	DVMXHQNZOXJFOZ-QFIPXVFZSA-N	326903	US9662327, Compound 489	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326903	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326903&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89288087	384581848							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642680	FC(F)(F)CC(=O)N1CCN(C[C@H]1C1CC1)c1nc(C2CC2)c2CN(CCc2c1C#N)C(=O)C=C	InChI=1S/C25H28F3N5O2/c1-2-21(34)31-8-7-17-18(12-29)24(30-23(16-5-6-16)19(17)13-31)32-9-10-33(20(14-32)15-3-4-15)22(35)11-25(26,27)28/h2,15-16,20H,1,3-11,13-14H2/t20-/m0/s1	CUOIJENYYXREKV-FQEVSTJZSA-N	326904	US9662327, Compound 490	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326904	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326904&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89288100	384581849							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642681	O=C(C#C)N1CCc2c(C1)c(nc(N1CCN([C@@H](C1)C1CC1)C(=O)C1CC1)c2C#N)C1CC1	InChI=1S/C26H29N5O2/c1-2-23(32)29-10-9-19-20(13-27)25(28-24(17-5-6-17)21(19)14-29)30-11-12-31(26(33)18-7-8-18)22(15-30)16-3-4-16/h1,16-18,22H,3-12,14-15H2/t22-/m0/s1	CMJNHJWYQJVTTC-QFIPXVFZSA-N	326905	US9662327, Compound 491	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326905	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326905&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89288252	384581850							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642682	COCCC(=O)N1CCN(C[C@H]1C1CC1)c1nc(C2CC2)c2CCN(Cc2c1C#N)C(=O)C(F)=C	InChI=1S/C26H32FN5O3/c1-16(27)26(34)31-9-7-19-21(14-31)20(13-28)25(29-24(19)18-5-6-18)30-10-11-32(23(33)8-12-35-2)22(15-30)17-3-4-17/h17-18,22H,1,3-12,14-15H2,2H3/t22-/m0/s1	XKCNTPIGBLKMKQ-QFIPXVFZSA-N	326906	US9662327, Compound 492	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326906	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326906&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295216	384581851							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642683	C=CS(=O)(=O)N1CCc2c(C1)c(nc(N1CCN([C@@H](C1)C1CC1)C(=O)C1CC1)c2C#N)C1CC1	InChI=1S/C25H31N5O3S/c1-2-34(32,33)29-10-9-19-20(13-26)24(27-23(17-5-6-17)21(19)14-29)28-11-12-30(25(31)18-7-8-18)22(15-28)16-3-4-16/h2,16-18,22H,1,3-12,14-15H2/t22-/m0/s1	XUINQRJVYHXGCQ-QFIPXVFZSA-N	326907	US9662327, Compound 493	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326907	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326907&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89288035	384581852							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642684	COC(=O)N1CCc2c(C1)c(nc(N1CCN([C@@H](C1)C1CC1)C(=O)C1CC1)c2C#N)C1CC1	InChI=1S/C25H31N5O3/c1-33-25(32)29-9-8-18-19(12-26)23(27-22(16-4-5-16)20(18)13-29)28-10-11-30(24(31)17-6-7-17)21(14-28)15-2-3-15/h15-17,21H,2-11,13-14H2,1H3/t21-/m0/s1	QTPFANDLULJGHZ-NRFANRHFSA-N	326908	US9662327, Compound 494	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326908	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326908&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119348	384581853							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642685	COC(=O)c1ccc(c(F)c1)-c1nc(C2CC2)c2CN(CCc2c1C#N)C(=O)C#C	InChI=1S/C23H18FN3O3/c1-3-20(28)27-9-8-15-17(11-25)22(26-21(13-4-5-13)18(15)12-27)16-7-6-14(10-19(16)24)23(29)30-2/h1,6-7,10,13H,4-5,8-9,12H2,2H3	DLEUCAVWRGPCDW-UHFFFAOYSA-N	326909	US9662327, Compound 495	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326909	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326909&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295217	384581854							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642686	COC(=O)c1ccc(c(F)c1)-c1nc(C2CC2)c2CN(CCc2c1C#N)S(=O)(=O)C=C	InChI=1S/C22H20FN3O4S/c1-3-31(28,29)26-9-8-15-17(11-24)21(25-20(13-4-5-13)18(15)12-26)16-7-6-14(10-19(16)23)22(27)30-2/h3,6-7,10,13H,1,4-5,8-9,12H2,2H3	LWRULJXEFSWHEX-UHFFFAOYSA-N	326910	US9662327, Compound 496	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326910	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326910&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295218	384581855							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642687	O=C(CC#N)N1CCc2c(C1)c(nc(N1CCN([C@@H](C1)C1CC1)C(=O)C1CC1)c2C#N)C1CC1	InChI=1S/C26H30N6O2/c27-9-7-23(33)30-10-8-19-20(13-28)25(29-24(17-3-4-17)21(19)14-30)31-11-12-32(26(34)18-5-6-18)22(15-31)16-1-2-16/h16-18,22H,1-8,10-12,14-15H2/t22-/m0/s1	GZVIZUPUWCXAEK-QFIPXVFZSA-N	326911	US9662327, Compound 497	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326911	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326911&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71119387	384581856							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642688	OCCC(=O)N1CCN(C[C@H]1C1CC1)c1nc(C2CC2)c2CN(CCc2c1C#N)C(=O)C=C	InChI=1S/C25H31N5O3/c1-2-22(32)28-9-7-18-19(13-26)25(27-24(17-5-6-17)20(18)14-28)29-10-11-30(23(33)8-12-31)21(15-29)16-3-4-16/h2,16-17,21,31H,1,3-12,14-15H2/t21-/m0/s1	MCOJZVCQNLGOFX-NRFANRHFSA-N	326912	US9662327, Compound 498	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<500							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326912	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326912&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89288386	384581857							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642689	C\C=C\C(=O)N1CCc2c(C1)c(nc(N1CCN([C@@H](C1)C1CC1)C(=O)C1CC1)c2C#N)C1CC1	InChI=1S/C27H33N5O2/c1-2-3-24(33)30-11-10-20-21(14-28)26(29-25(18-6-7-18)22(20)15-30)31-12-13-32(27(34)19-8-9-19)23(16-31)17-4-5-17/h2-3,17-19,23H,4-13,15-16H2,1H3/b3-2+/t23-/m0/s1	RSCMUPZOWWUKCF-XFBYCMBJSA-N	326913	US9662327, Compound 499	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326913	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326913&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71118581	384581858							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642690	OCCC(=O)N1CCN(C[C@H]1C1CC1)c1nc(C2CC2)c2CN(CCc2c1C#N)C(=O)C#C	InChI=1S/C25H29N5O3/c1-2-22(32)28-9-7-18-19(13-26)25(27-24(17-5-6-17)20(18)14-28)29-10-11-30(23(33)8-12-31)21(15-29)16-3-4-16/h1,16-17,21,31H,3-12,14-15H2/t21-/m0/s1	UMQNVVNDWDXMPY-NRFANRHFSA-N	326914	US9662327, Compound 500	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326914	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326914&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89288508	384581859							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642691	COCCC(=O)N1CCN(C[C@H]1C1CC1)c1nc(C2CC2)c2CN(CCc2c1C#N)C(=O)CCO	InChI=1S/C26H35N5O4/c1-35-13-8-24(34)31-11-10-30(16-22(31)17-2-3-17)26-20(14-27)19-6-9-29(23(33)7-12-32)15-21(19)25(28-26)18-4-5-18/h17-18,22,32H,2-13,15-16H2,1H3/t22-/m0/s1	VRYDKFJCIOXYIY-QFIPXVFZSA-N	326915	US9662327, Compound 501	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326915	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326915&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90283371	384581860							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642692	COCCC(=O)N1CCN(C[C@H]1C1CC1)c1nc(C2CC2)c2CN(CCc2c1C#N)C(=O)C(C)=C	InChI=1S/C27H35N5O3/c1-17(2)27(34)31-10-8-20-21(14-28)26(29-25(19-6-7-19)22(20)15-31)30-11-12-32(24(33)9-13-35-3)23(16-30)18-4-5-18/h18-19,23H,1,4-13,15-16H2,2-3H3/t23-/m0/s1	FWDUBPKVOITXDQ-QHCPKHFHSA-N	326916	US9662327, Compound 502	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326916	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326916&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90282700	384581861							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
642693	CN1CCN(CC1)c1nc(C2CC2)c2CN(CCc2c1C#N)S(=O)(=O)C=C	InChI=1S/C19H25N5O2S/c1-3-27(25,26)24-7-6-15-16(12-20)19(23-10-8-22(2)9-11-23)21-18(14-4-5-14)17(15)13-24/h3,14H,1,4-11,13H2,2H3	BGVVSHFYFQGIBP-UHFFFAOYSA-N	326917	US9662327, Compound 503	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 750							US Patent		10.7270/Q2RB76P0		aid1796785	US9662327	Cao, S; Popovici-Muller, J; Salituro, FG; Saunders, JO; Tan, X; Travins, J; Yan, S; Ye, Z	5/30/2017	6/3/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=326917	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=326917&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90295219	384581862							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669430	Cc1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1S(=O)(=O)Nc1ccccc1	InChI=1S/C20H18ClN3O3S/c1-14-7-10-18(23-20(25)22-16-11-8-15(21)9-12-16)13-19(14)28(26,27)24-17-5-3-2-4-6-17/h2-13,24H,1H3,(H2,22,23,25)	RXTKDXIITDQDDH-UHFFFAOYSA-N	339428	US10202339, Compound 205	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339428	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339428&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673047	385210290							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669431	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1ccccc1	InChI=1S/C21H18F3N3O3S/c1-14-10-11-18(13-19(14)31(29,30)27-16-7-3-2-4-8-16)26-20(28)25-17-9-5-6-15(12-17)21(22,23)24/h2-13,27H,1H3,(H2,25,26,28)	IMTDFQKWPLYOFA-UHFFFAOYSA-N	339429	US10202339, Compound 206	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339429	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339429&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673048	385210291							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669432	Cc1ccc(NC(=O)Nc2ccc(cc2)C(F)(F)F)cc1S(=O)(=O)Nc1ccccc1	InChI=1S/C21H18F3N3O3S/c1-14-7-10-18(13-19(14)31(29,30)27-17-5-3-2-4-6-17)26-20(28)25-16-11-8-15(9-12-16)21(22,23)24/h2-13,27H,1H3,(H2,25,26,28)	NPZYUWKGXZDZTD-UHFFFAOYSA-N	339430	US10202339, Compound 207	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339430	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339430&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673049	385210292							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669433	Cc1ccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1S(=O)(=O)Nc1ccccc1	InChI=1S/C21H18F3N3O4S/c1-14-7-8-17(13-19(14)32(29,30)27-16-5-3-2-4-6-16)26-20(28)25-15-9-11-18(12-10-15)31-21(22,23)24/h2-13,27H,1H3,(H2,25,26,28)	FXWGNUUDISXXRI-UHFFFAOYSA-N	339431	US10202339, Compound 208	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339431	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339431&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673050	385210293							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669434	Cc1ccc(NC(=O)Nc2ccc(F)c(Cl)c2)cc1S(=O)(=O)Nc1ccccc1	InChI=1S/C20H17ClFN3O3S/c1-13-7-8-16(24-20(26)23-15-9-10-18(22)17(21)11-15)12-19(13)29(27,28)25-14-5-3-2-4-6-14/h2-12,25H,1H3,(H2,23,24,26)	BITIKSUAENOXNS-UHFFFAOYSA-N	339432	US10202339, Compound 209	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339432	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339432&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673051	385210294							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669435	Cc1cc(C)cc(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccccc2)c1	InChI=1S/C22H23N3O3S/c1-15-11-16(2)13-20(12-15)24-22(26)23-19-10-9-17(3)21(14-19)29(27,28)25-18-7-5-4-6-8-18/h4-14,25H,1-3H3,(H2,23,24,26)	ORWCQOYPFDAWMY-UHFFFAOYSA-N	339433	US10202339, Compound 210	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339433	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339433&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673171	385210295							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669436	Cc1ccc(NC(=O)Nc2cccc(c2)C#C)cc1S(=O)(=O)Nc1ccccc1	InChI=1S/C22H19N3O3S/c1-3-17-8-7-11-19(14-17)23-22(26)24-20-13-12-16(2)21(15-20)29(27,28)25-18-9-5-4-6-10-18/h1,4-15,25H,2H3,(H2,23,24,26)	NRDWAJXUPKVORF-UHFFFAOYSA-N	339434	US10202339, Compound 211	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339434	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339434&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673172	385210296							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669437	Cc1ccc(NC(=O)Nc2cccc(Oc3ccccc3)c2)cc1S(=O)(=O)Nc1ccccc1	InChI=1S/C26H23N3O4S/c1-19-15-16-22(18-25(19)34(31,32)29-20-9-4-2-5-10-20)28-26(30)27-21-11-8-14-24(17-21)33-23-12-6-3-7-13-23/h2-18,29H,1H3,(H2,27,28,30)	SSQLUKHZRTVJKI-UHFFFAOYSA-N	339435	US10202339, Compound 212	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339435	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339435&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145390	385210297							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669438	Cc1ccc(NC(=O)Nc2ccccc2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H18ClN3O3S/c1-14-7-10-18(23-20(25)22-16-5-3-2-4-6-16)13-19(14)28(26,27)24-17-11-8-15(21)9-12-17/h2-13,24H,1H3,(H2,22,23,25)	MJLGNFPMQODSCL-UHFFFAOYSA-N	339436	US10202339, Compound 213	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339436	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339436&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145391	385210298							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669439	Cc1ccc(NC(=O)Nc2ccccc2Cl)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H17Cl2N3O3S/c1-13-6-9-16(23-20(26)24-18-5-3-2-4-17(18)22)12-19(13)29(27,28)25-15-10-7-14(21)8-11-15/h2-12,25H,1H3,(H2,23,24,26)	IFBMFVBMNFJJMA-UHFFFAOYSA-N	339437	US10202339, Compound 214	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339437	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339437&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673174	385210299							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669440	Cc1ccc(NC(=O)Nc2cccc(Cl)c2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H17Cl2N3O3S/c1-13-5-8-18(24-20(26)23-17-4-2-3-15(22)11-17)12-19(13)29(27,28)25-16-9-6-14(21)7-10-16/h2-12,25H,1H3,(H2,23,24,26)	NYWJKAFGGXHLPG-UHFFFAOYSA-N	339438	US10202339, Compound 215	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339438	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339438&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673175	385210300							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669441	Cc1ccc(NC(=O)Nc2ccccc2Br)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H17BrClN3O3S/c1-13-6-9-16(23-20(26)24-18-5-3-2-4-17(18)21)12-19(13)29(27,28)25-15-10-7-14(22)8-11-15/h2-12,25H,1H3,(H2,23,24,26)	GDXKSCMHCAZRPC-UHFFFAOYSA-N	339439	US10202339, Compound 216	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339439	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339439&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673176	385210301							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669442	Cc1ccc(NC(=O)Nc2ccc(Br)cc2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H17BrClN3O3S/c1-13-2-7-18(24-20(26)23-16-8-3-14(21)4-9-16)12-19(13)29(27,28)25-17-10-5-15(22)6-11-17/h2-12,25H,1H3,(H2,23,24,26)	ZHVMIQOMNSHRNU-UHFFFAOYSA-N	339440	US10202339, Compound 217	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339440	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339440&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673293	385210302							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669443	Cc1ccc(NC(=O)Nc2ccccc2F)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H17ClFN3O3S/c1-13-6-9-16(23-20(26)24-18-5-3-2-4-17(18)22)12-19(13)29(27,28)25-15-10-7-14(21)8-11-15/h2-12,25H,1H3,(H2,23,24,26)	ZSCNNIVSLMGKCJ-UHFFFAOYSA-N	339441	US10202339, Compound 218	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339441	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339441&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673294	385210303							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669444	Cc1ccc(NC(=O)Nc2ccc(F)cc2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H17ClFN3O3S/c1-13-2-7-18(24-20(26)23-16-10-5-15(22)6-11-16)12-19(13)29(27,28)25-17-8-3-14(21)4-9-17/h2-12,25H,1H3,(H2,23,24,26)	XTFJEPMRGQPNEK-UHFFFAOYSA-N	339442	US10202339, Compound 219	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339442	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339442&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673295	385210304							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669445	Cc1ccc(NC(=O)Nc2ccc(I)cc2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H17ClIN3O3S/c1-13-2-7-18(24-20(26)23-16-10-5-15(22)6-11-16)12-19(13)29(27,28)25-17-8-3-14(21)4-9-17/h2-12,25H,1H3,(H2,23,24,26)	QZKGGDIKZXRNEQ-UHFFFAOYSA-N	339443	US10202339, Compound 220	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339443	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339443&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673296	385210305							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669446	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H17ClF3N3O3S/c1-13-5-8-18(12-19(13)32(30,31)28-16-9-6-15(22)7-10-16)27-20(29)26-17-4-2-3-14(11-17)21(23,24)25/h2-12,28H,1H3,(H2,26,27,29)	SNFGQBKZUJNMKA-UHFFFAOYSA-N	339444	US10202339, Compound 221	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339444	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339444&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			4078245	385210306							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669447	Cc1ccc(NC(=O)Nc2ccc(cc2)C(F)(F)F)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H17ClF3N3O3S/c1-13-2-7-18(12-19(13)32(30,31)28-17-10-5-15(22)6-11-17)27-20(29)26-16-8-3-14(4-9-16)21(23,24)25/h2-12,28H,1H3,(H2,26,27,29)	YGEDDHPZNCSORA-UHFFFAOYSA-N	339445	US10202339, Compound 222	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339445	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339445&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90101637	385210307							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669448	Cc1ccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H17ClF3N3O4S/c1-13-2-5-17(12-19(13)33(30,31)28-16-6-3-14(22)4-7-16)27-20(29)26-15-8-10-18(11-9-15)32-21(23,24)25/h2-12,28H,1H3,(H2,26,27,29)	ZKPPADWAAYEWMJ-UHFFFAOYSA-N	339446	US10202339, Compound 223::US10202339, Compound 225	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339446	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339446&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145571	385210308							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669449	Cc1ccc(NC(=O)Nc2ccccc2OC(F)(F)F)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H17ClF3N3O4S/c1-13-6-9-16(12-19(13)33(30,31)28-15-10-7-14(22)8-11-15)26-20(29)27-17-4-2-3-5-18(17)32-21(23,24)25/h2-12,28H,1H3,(H2,26,27,29)	HZWRDGAHRDIHTQ-UHFFFAOYSA-N	339447	US10202339, Compound 224	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339447	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339447&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673416	385210309							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669450	Cc1ccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H17ClF3N3O4S/c1-13-2-5-17(12-19(13)33(30,31)28-16-6-3-14(22)4-7-16)27-20(29)26-15-8-10-18(11-9-15)32-21(23,24)25/h2-12,28H,1H3,(H2,26,27,29)	ZKPPADWAAYEWMJ-UHFFFAOYSA-N	339446	US10202339, Compound 223::US10202339, Compound 225	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339446	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339446&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145571	385210308							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669451	Cc1ccc(NC(=O)Nc2ccc(Br)cc2Cl)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H16BrCl2N3O3S/c1-12-2-6-16(24-20(27)25-18-9-3-13(21)10-17(18)23)11-19(12)30(28,29)26-15-7-4-14(22)5-8-15/h2-11,26H,1H3,(H2,24,25,27)	YRQOBYFJUATTOE-UHFFFAOYSA-N	339449	US10202339, Compound 227	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339449	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339449&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673417	385210310							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669452	Cc1ccc(NC(=O)Nc2ccc(F)c(Cl)c2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H16Cl2FN3O3S/c1-12-2-5-16(25-20(27)24-15-8-9-18(23)17(22)10-15)11-19(12)30(28,29)26-14-6-3-13(21)4-7-14/h2-11,26H,1H3,(H2,24,25,27)	UQZSKYDBQQKVNK-UHFFFAOYSA-N	339450	US10202339, Compound 228	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339450	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339450&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673418	385210311							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669453	Cc1ccc(NC(=O)Nc2ccc(F)cc2F)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H16ClF2N3O3S/c1-12-2-6-16(24-20(27)25-18-9-5-14(22)10-17(18)23)11-19(12)30(28,29)26-15-7-3-13(21)4-8-15/h2-11,26H,1H3,(H2,24,25,27)	NUIPUHNNRZVRGL-UHFFFAOYSA-N	339451	US10202339, Compound 229	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339451	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339451&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673419	385210312							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669454	Cc1ccc(NC(=O)Nc2ccc(F)c(F)c2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H16ClF2N3O3S/c1-12-2-5-16(25-20(27)24-15-8-9-17(22)18(23)10-15)11-19(12)30(28,29)26-14-6-3-13(21)4-7-14/h2-11,26H,1H3,(H2,24,25,27)	HQQZTBKVMJKOHU-UHFFFAOYSA-N	339452	US10202339, Compound 230	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339452	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339452&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673420	385210313							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669455	Cc1ccc(NC(=O)Nc2ccc(cc2Cl)C(F)(F)F)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H16Cl2F3N3O3S/c1-12-2-6-16(11-19(12)33(31,32)29-15-7-4-14(22)5-8-15)27-20(30)28-18-9-3-13(10-17(18)23)21(24,25)26/h2-11,29H,1H3,(H2,27,28,30)	USYVHLLAHMDNMC-UHFFFAOYSA-N	339453	US10202339, Compound 231	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339453	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339453&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673421	385210314							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669456	Cc1ccc(NC(=O)Nc2ccc(Br)cc2OC(F)(F)F)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H16BrClF3N3O4S/c1-12-2-6-16(11-19(12)34(31,32)29-15-7-4-14(23)5-8-15)27-20(30)28-17-9-3-13(22)10-18(17)33-21(24,25)26/h2-11,29H,1H3,(H2,27,28,30)	FGVVCAFACUFTIM-UHFFFAOYSA-N	339454	US10202339, Compound 232	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339454	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339454&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673546	385210315							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669457	Cc1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H16ClF4N3O3S/c1-12-2-6-16(11-19(12)33(31,32)29-15-7-4-14(22)5-8-15)27-20(30)28-18-10-13(21(24,25)26)3-9-17(18)23/h2-11,29H,1H3,(H2,27,28,30)	CRRLOPOVGBJCIE-UHFFFAOYSA-N	339455	US10202339, Compound 233	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339455	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339455&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673547	385210316							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669458	Cc1cccc(Cl)c1NC(=O)Nc1ccc(C)c(c1)S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H19Cl2N3O3S/c1-13-6-9-17(24-21(27)25-20-14(2)4-3-5-18(20)23)12-19(13)30(28,29)26-16-10-7-15(22)8-11-16/h3-12,26H,1-2H3,(H2,24,25,27)	MUGYIKWHRWMBDY-UHFFFAOYSA-N	339456	US10202339, Compound 234	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339456	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339456&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673548	385210317							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669459	Cc1ccc(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)cc1Cl	InChI=1S/C21H19Cl2N3O3S/c1-13-3-7-17(11-19(13)23)24-21(27)25-18-8-4-14(2)20(12-18)30(28,29)26-16-9-5-15(22)6-10-16/h3-12,26H,1-2H3,(H2,24,25,27)	QDJWQYMTOOAQQR-UHFFFAOYSA-N	339457	US10202339, Compound 235	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339457	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339457&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673549	385210318							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669460	Cc1ccc(NC(=O)Nc2ccc(Cl)cc2C)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H19Cl2N3O3S/c1-13-3-7-18(24-21(27)25-19-10-6-16(23)11-14(19)2)12-20(13)30(28,29)26-17-8-4-15(22)5-9-17/h3-12,26H,1-2H3,(H2,24,25,27)	ZTAYPGNLCHKHLB-UHFFFAOYSA-N	339458	US10202339, Compound 236	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339458	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339458&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673550	385210319							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669461	Cc1ccc(NC(=O)Nc2ccc(Br)c(C)c2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H19BrClN3O3S/c1-13-3-6-18(25-21(27)24-17-9-10-19(22)14(2)11-17)12-20(13)30(28,29)26-16-7-4-15(23)5-8-16/h3-12,26H,1-2H3,(H2,24,25,27)	HZJLIQYPKPIOMP-UHFFFAOYSA-N	339459	US10202339, Compound 237	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339459	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339459&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673551	385210320							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669462	Cc1cc(Br)ccc1NC(=O)Nc1ccc(C)c(c1)S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H19BrClN3O3S/c1-13-3-7-18(24-21(27)25-19-10-4-15(22)11-14(19)2)12-20(13)30(28,29)26-17-8-5-16(23)6-9-17/h3-12,26H,1-2H3,(H2,24,25,27)	BXYGIQKIXOZKDP-UHFFFAOYSA-N	339460	US10202339, Compound 238	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339460	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339460&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673661	385210321							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669463	Cc1cc(Br)cc(C)c1NC(=O)Nc1ccc(C)c(c1)S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C22H21BrClN3O3S/c1-13-4-7-19(25-22(28)26-21-14(2)10-16(23)11-15(21)3)12-20(13)31(29,30)27-18-8-5-17(24)6-9-18/h4-12,27H,1-3H3,(H2,25,26,28)	YIQKWRNCHUZHOT-UHFFFAOYSA-N	339461	US10202339, Compound 239	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339461	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339461&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673662	385210322							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669464	Cc1ccc(F)c(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)c1	InChI=1S/C21H19ClFN3O3S/c1-13-3-10-18(23)19(11-13)25-21(27)24-17-7-4-14(2)20(12-17)30(28,29)26-16-8-5-15(22)6-9-16/h3-12,26H,1-2H3,(H2,24,25,27)	HUWFJOJGYCNGDX-UHFFFAOYSA-N	339462	US10202339, Compound 240	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339462	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339462&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145572	385210323							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669465	Cc1ccc(F)cc1NC(=O)Nc1ccc(C)c(c1)S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H19ClFN3O3S/c1-13-3-7-16(23)11-19(13)25-21(27)24-18-8-4-14(2)20(12-18)30(28,29)26-17-9-5-15(22)6-10-17/h3-12,26H,1-2H3,(H2,24,25,27)	BSBZAIAJJASPKL-UHFFFAOYSA-N	339463	US10202339, Compound 241	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339463	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339463&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673664	385210324							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669466	Cc1ccc(NC(=O)Nc2ccc(Cl)c(c2)[N+]([O-])=O)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H16Cl2N4O5S/c1-12-2-5-16(11-19(12)32(30,31)25-14-6-3-13(21)4-7-14)24-20(27)23-15-8-9-17(22)18(10-15)26(28)29/h2-11,25H,1H3,(H2,23,24,27)	UPYZJORTPRRSDD-UHFFFAOYSA-N	339464	US10202339, Compound 242	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339464	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339464&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673665	385210325							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669467	Cc1ccc(NC(=O)Nc2cc(Cl)ccc2[N+]([O-])=O)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H16Cl2N4O5S/c1-12-2-6-16(11-19(12)32(30,31)25-15-7-3-13(21)4-8-15)23-20(27)24-17-10-14(22)5-9-18(17)26(28)29/h2-11,25H,1H3,(H2,23,24,27)	MVUOVAFCIYHQKH-UHFFFAOYSA-N	339465	US10202339, Compound 243	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339465	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339465&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673666	385210326							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669468	Cc1ccc(NC(=O)Nc2ccc(cc2Cl)[N+]([O-])=O)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H16Cl2N4O5S/c1-12-2-5-15(10-19(12)32(30,31)25-14-6-3-13(21)4-7-14)23-20(27)24-18-9-8-16(26(28)29)11-17(18)22/h2-11,25H,1H3,(H2,23,24,27)	CZJBNIAJFBBAKX-UHFFFAOYSA-N	339466	US10202339, Compound 244	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339466	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339466&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73671865	385210327							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669469	Cc1ccc(NC(=O)Nc2ccc(F)cc2[N+]([O-])=O)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H16ClFN4O5S/c1-12-2-6-16(11-19(12)32(30,31)25-15-7-3-13(21)4-8-15)23-20(27)24-17-9-5-14(22)10-18(17)26(28)29/h2-11,25H,1H3,(H2,23,24,27)	IHJAILITQJNETE-UHFFFAOYSA-N	339467	US10202339, Compound 245	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339467	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339467&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73671866	385210328							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669470	Cc1ccc(NC(=O)Nc2cc(Cl)c(Cl)cc2Cl)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H15Cl4N3O3S/c1-11-2-5-14(25-20(28)26-18-10-16(23)15(22)9-17(18)24)8-19(11)31(29,30)27-13-6-3-12(21)4-7-13/h2-10,27H,1H3,(H2,25,26,28)	HMCLPNRMYRPQOE-UHFFFAOYSA-N	339468	US10202339, Compound 246	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339468	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339468&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73671867	385210329							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669471	Cc1ccc(NC(=O)Nc2c(Cl)cc(F)cc2Br)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H15BrCl2FN3O3S/c1-11-2-5-15(25-20(28)26-19-16(21)8-13(24)9-17(19)23)10-18(11)31(29,30)27-14-6-3-12(22)4-7-14/h2-10,27H,1H3,(H2,25,26,28)	RFUKNBONPLNTQO-UHFFFAOYSA-N	339469	US10202339, Compound 247	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339469	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339469&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137483092	385210330							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669472	Cc1ccc(NC(=O)Nc2ccc(F)c(F)c2F)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H15ClF3N3O3S/c1-11-2-5-14(25-20(28)26-16-9-8-15(22)18(23)19(16)24)10-17(11)31(29,30)27-13-6-3-12(21)4-7-13/h2-10,27H,1H3,(H2,25,26,28)	HJKRXHCGUNLQQG-UHFFFAOYSA-N	339470	US10202339, Compound 248	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339470	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339470&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73671869	385210331							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669473	Cc1cccc(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)c1	InChI=1S/C21H20ClN3O3S/c1-14-4-3-5-18(12-14)23-21(26)24-19-9-6-15(2)20(13-19)29(27,28)25-17-10-7-16(22)8-11-17/h3-13,25H,1-2H3,(H2,23,24,26)	DHHDKOZTQCUDLK-UHFFFAOYSA-N	339471	US10202339, Compound 249	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339471	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339471&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73671870	385210332							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669474	CCc1ccccc1NC(=O)Nc1ccc(C)c(c1)S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C22H22ClN3O3S/c1-3-16-6-4-5-7-20(16)25-22(27)24-19-11-8-15(2)21(14-19)30(28,29)26-18-12-9-17(23)10-13-18/h4-14,26H,3H2,1-2H3,(H2,24,25,27)	QLZRCPOSHZHZSW-UHFFFAOYSA-N	339472	US10202339, Compound 250	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339472	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339472&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73671974	385210333							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669475	CCc1cccc(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)c1	InChI=1S/C22H22ClN3O3S/c1-3-16-5-4-6-19(13-16)24-22(27)25-20-10-7-15(2)21(14-20)30(28,29)26-18-11-8-17(23)9-12-18/h4-14,26H,3H2,1-2H3,(H2,24,25,27)	GBSVJWLOONGXFX-UHFFFAOYSA-N	339473	US10202339, Compound 251	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339473	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339473&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73671975	385210334							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669476	CCc1ccc(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)cc1	InChI=1S/C22H22ClN3O3S/c1-3-16-5-10-18(11-6-16)24-22(27)25-20-9-4-15(2)21(14-20)30(28,29)26-19-12-7-17(23)8-13-19/h4-14,26H,3H2,1-2H3,(H2,24,25,27)	PVIUEEFTPUOBQZ-UHFFFAOYSA-N	339474	US10202339, Compound 252	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339474	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339474&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73671976	385210335							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669477	CCCCc1ccc(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)cc1	InChI=1S/C24H26ClN3O3S/c1-3-4-5-18-7-12-20(13-8-18)26-24(29)27-22-11-6-17(2)23(16-22)32(30,31)28-21-14-9-19(25)10-15-21/h6-16,28H,3-5H2,1-2H3,(H2,26,27,29)	GEZHXFYOEKOJIY-UHFFFAOYSA-N	339475	US10202339, Compound 253	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339475	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339475&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73671977	385210336							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669478	CC(C)c1ccc(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)cc1	InChI=1S/C23H24ClN3O3S/c1-15(2)17-5-10-19(11-6-17)25-23(28)26-21-9-4-16(3)22(14-21)31(29,30)27-20-12-7-18(24)8-13-20/h4-15,27H,1-3H3,(H2,25,26,28)	RETXEPDLZRICLS-UHFFFAOYSA-N	339476	US10202339, Compound 254	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339476	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339476&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73671978	385210337							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669479	Cc1ccc(NC(=O)Nc2ccccc2C(C)(C)C)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C24H26ClN3O3S/c1-16-9-12-19(15-22(16)32(30,31)28-18-13-10-17(25)11-14-18)26-23(29)27-21-8-6-5-7-20(21)24(2,3)4/h5-15,28H,1-4H3,(H2,26,27,29)	ORSIPMRKHBYGSJ-UHFFFAOYSA-N	339477	US10202339, Compound 255	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339477	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339477&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73671979	385210338							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669480	Cc1ccc(NC(=O)Nc2ccc(cc2)C(C)(C)C)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C24H26ClN3O3S/c1-16-5-10-21(15-22(16)32(30,31)28-20-13-8-18(25)9-14-20)27-23(29)26-19-11-6-17(7-12-19)24(2,3)4/h5-15,28H,1-4H3,(H2,26,27,29)	AZVDWGFTTCEVHX-UHFFFAOYSA-N	339478	US10202339, Compound 256	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339478	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339478&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672090	385210339							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669481	Cc1cccc(C)c1NC(=O)Nc1ccc(C)c(c1)S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C22H22ClN3O3S/c1-14-7-10-19(24-22(27)25-21-15(2)5-4-6-16(21)3)13-20(14)30(28,29)26-18-11-8-17(23)9-12-18/h4-13,26H,1-3H3,(H2,24,25,27)	OTUOOABRYQQNBT-UHFFFAOYSA-N	339479	US10202339, Compound 257	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339479	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339479&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672091	385210340							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669482	Cc1cccc(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)c1C	InChI=1S/C22H22ClN3O3S/c1-14-5-4-6-20(16(14)3)25-22(27)24-19-10-7-15(2)21(13-19)30(28,29)26-18-11-8-17(23)9-12-18/h4-13,26H,1-3H3,(H2,24,25,27)	YRZNRNFQSCYWQE-UHFFFAOYSA-N	339480	US10202339, Compound 258	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339480	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339480&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672092	385210341							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669483	Cc1ccc(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)cc1C	InChI=1S/C22H22ClN3O3S/c1-14-4-8-19(12-16(14)3)24-22(27)25-20-9-5-15(2)21(13-20)30(28,29)26-18-10-6-17(23)7-11-18/h4-13,26H,1-3H3,(H2,24,25,27)	RFVKKYLXFGLQNW-UHFFFAOYSA-N	339481	US10202339, Compound 259	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339481	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339481&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145348	385210342							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669484	Cc1cc(C)cc(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)c1	InChI=1S/C22H22ClN3O3S/c1-14-10-15(2)12-20(11-14)25-22(27)24-19-7-4-16(3)21(13-19)30(28,29)26-18-8-5-17(23)6-9-18/h4-13,26H,1-3H3,(H2,24,25,27)	RFQTXZFPARWFBA-UHFFFAOYSA-N	339482	US10202339, Compound 260	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339482	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339482&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672093	385210343							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669485	CCc1cccc(CC)c1NC(=O)Nc1ccc(C)c(c1)S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C24H26ClN3O3S/c1-4-17-7-6-8-18(5-2)23(17)27-24(29)26-21-12-9-16(3)22(15-21)32(30,31)28-20-13-10-19(25)11-14-20/h6-15,28H,4-5H2,1-3H3,(H2,26,27,29)	XLRXJQJZQFOPEM-UHFFFAOYSA-N	339483	US10202339, Compound 261	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339483	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339483&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672094	385210344							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669486	Cc1cc(ccc1NC(=O)Nc1ccc(C)c(c1)S(=O)(=O)Nc1ccc(Cl)cc1)[N+]([O-])=O	InChI=1S/C21H19ClN4O5S/c1-13-3-6-17(12-20(13)32(30,31)25-16-7-4-15(22)5-8-16)23-21(27)24-19-10-9-18(26(28)29)11-14(19)2/h3-12,25H,1-2H3,(H2,23,24,27)	KRUMICJAGJMPIO-UHFFFAOYSA-N	339484	US10202339, Compound 262	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339484	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339484&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672095	385210345							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669487	Cc1ccc(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)cc1[N+]([O-])=O	InChI=1S/C21H19ClN4O5S/c1-13-3-7-17(11-19(13)26(28)29)23-21(27)24-18-8-4-14(2)20(12-18)32(30,31)25-16-9-5-15(22)6-10-16/h3-12,25H,1-2H3,(H2,23,24,27)	XMJWXWGPDVLEFY-UHFFFAOYSA-N	339485	US10202339, Compound 263	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339485	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339485&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672200	385210346							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669488	Cc1ccc(NC(=O)Nc2cccc(c2C)[N+]([O-])=O)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H19ClN4O5S/c1-13-6-9-17(12-20(13)32(30,31)25-16-10-7-15(22)8-11-16)23-21(27)24-18-4-3-5-19(14(18)2)26(28)29/h3-12,25H,1-2H3,(H2,23,24,27)	QHRKOLUHGNRYNN-UHFFFAOYSA-N	339486	US10202339, Compound 264	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339486	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339486&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672201	385210347							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669489	COc1ccccc1NC(=O)Nc1ccc(C)c(c1)S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H20ClN3O4S/c1-14-7-10-17(23-21(26)24-18-5-3-4-6-19(18)29-2)13-20(14)30(27,28)25-16-11-8-15(22)9-12-16/h3-13,25H,1-2H3,(H2,23,24,26)	CJIJUXURIIYVDB-UHFFFAOYSA-N	339487	US10202339, Compound 265	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339487	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339487&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672202	385210348							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669490	COc1cccc(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)c1	InChI=1S/C21H20ClN3O4S/c1-14-6-9-18(24-21(26)23-17-4-3-5-19(12-17)29-2)13-20(14)30(27,28)25-16-10-7-15(22)8-11-16/h3-13,25H,1-2H3,(H2,23,24,26)	PSNDVUPZVGJXDL-UHFFFAOYSA-N	339488	US10202339, Compound 266	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339488	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339488&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672203	385210349							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669491	COc1ccc(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)cc1	InChI=1S/C21H20ClN3O4S/c1-14-3-6-18(24-21(26)23-16-9-11-19(29-2)12-10-16)13-20(14)30(27,28)25-17-7-4-15(22)5-8-17/h3-13,25H,1-2H3,(H2,23,24,26)	FIXCZFRCTIMASC-UHFFFAOYSA-N	339489	US10202339, Compound 267	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339489	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339489&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672204	385210350							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669492	COc1ccc(OC)c(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)c1	InChI=1S/C22H22ClN3O5S/c1-14-4-7-17(12-21(14)32(28,29)26-16-8-5-15(23)6-9-16)24-22(27)25-19-13-18(30-2)10-11-20(19)31-3/h4-13,26H,1-3H3,(H2,24,25,27)	LHKQUVPSCDYFIC-UHFFFAOYSA-N	339490	US10202339, Compound 268	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339490	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339490&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672205	385210351							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669493	COc1cc(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)cc(OC)c1	InChI=1S/C22H22ClN3O5S/c1-14-4-7-17(12-21(14)32(28,29)26-16-8-5-15(23)6-9-16)24-22(27)25-18-10-19(30-2)13-20(11-18)31-3/h4-13,26H,1-3H3,(H2,24,25,27)	KFGYHKBOIPPJSG-UHFFFAOYSA-N	339491	US10202339, Compound 269	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339491	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339491&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672322	385210352							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669494	COc1ccc(Cl)cc1NC(=O)Nc1ccc(C)c(c1)S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H19Cl2N3O4S/c1-13-3-7-17(24-21(27)25-18-11-15(23)6-10-19(18)30-2)12-20(13)31(28,29)26-16-8-4-14(22)5-9-16/h3-12,26H,1-2H3,(H2,24,25,27)	KMSLFQHGERAUMG-UHFFFAOYSA-N	339492	US10202339, Compound 270	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339492	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339492&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145354	385210353							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669495	COc1cc(OC)c(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)cc1Cl	InChI=1S/C22H21Cl2N3O5S/c1-13-4-7-16(10-21(13)33(29,30)27-15-8-5-14(23)6-9-15)25-22(28)26-18-11-17(24)19(31-2)12-20(18)32-3/h4-12,27H,1-3H3,(H2,25,26,28)	VODWYVWJKCQPKV-UHFFFAOYSA-N	339493	US10202339, Compound 271	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339493	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339493&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672324	385210354							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669496	COc1cc(ccc1NC(=O)Nc1ccc(C)c(c1)S(=O)(=O)Nc1ccc(Cl)cc1)[N+]([O-])=O	InChI=1S/C21H19ClN4O6S/c1-13-3-6-16(11-20(13)33(30,31)25-15-7-4-14(22)5-8-15)23-21(27)24-18-10-9-17(26(28)29)12-19(18)32-2/h3-12,25H,1-2H3,(H2,23,24,27)	KJLYWMNORHGPEJ-UHFFFAOYSA-N	339494	US10202339, Compound 272	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339494	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339494&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672325	385210355							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669497	CSc1cccc(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)c1	InChI=1S/C21H20ClN3O3S2/c1-14-6-9-18(24-21(26)23-17-4-3-5-19(12-17)29-2)13-20(14)30(27,28)25-16-10-7-15(22)8-11-16/h3-13,25H,1-2H3,(H2,23,24,26)	YYRAFYFIXOVETJ-UHFFFAOYSA-N	339495	US10202339, Compound 273	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339495	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339495&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672326	385210356							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669498	CSc1ccc(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)cc1	InChI=1S/C21H20ClN3O3S2/c1-14-3-6-18(24-21(26)23-16-9-11-19(29-2)12-10-16)13-20(14)30(27,28)25-17-7-4-15(22)5-8-17/h3-13,25H,1-2H3,(H2,23,24,26)	VMMVQILIQQROQU-UHFFFAOYSA-N	339496	US10202339, Compound 274	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339496	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339496&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672327	385210357							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669499	Cc1ccc(NC(=O)Nc2cccc(c2)[N+]([O-])=O)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C20H17ClN4O5S/c1-13-5-8-17(23-20(26)22-16-3-2-4-18(11-16)25(27)28)12-19(13)31(29,30)24-15-9-6-14(21)7-10-15/h2-12,24H,1H3,(H2,22,23,26)	YHRIJTLMDRFXGT-UHFFFAOYSA-N	339497	US10202339, Compound 275	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339497	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339497&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672440	385210358							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669500	COC(=O)c1cccc(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)c1	InChI=1S/C22H20ClN3O5S/c1-14-6-9-19(13-20(14)32(29,30)26-17-10-7-16(23)8-11-17)25-22(28)24-18-5-3-4-15(12-18)21(27)31-2/h3-13,26H,1-2H3,(H2,24,25,28)	YZWYBZGFVQFVDV-UHFFFAOYSA-N	339498	US10202339, Compound 276	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339498	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339498&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672441	385210359							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669501	Cc1ccc(NC(=O)NCc2ccc(Br)cc2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H19BrClN3O3S/c1-14-2-9-19(25-21(27)24-13-15-3-5-16(22)6-4-15)12-20(14)30(28,29)26-18-10-7-17(23)8-11-18/h2-12,26H,13H2,1H3,(H2,24,25,27)	SUJWWLOHAMEPLR-UHFFFAOYSA-N	339499	US10202339, Compound 277	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339499	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339499&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672442	385210360							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669502	Cc1ccc(NC(=O)NCc2ccccc2F)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H19ClFN3O3S/c1-14-6-9-18(25-21(27)24-13-15-4-2-3-5-19(15)23)12-20(14)30(28,29)26-17-10-7-16(22)8-11-17/h2-12,26H,13H2,1H3,(H2,24,25,27)	LZOVLVDLCKYWFC-UHFFFAOYSA-N	339500	US10202339, Compound 278	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339500	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339500&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672443	385210361							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669503	Cc1ccc(NC(=O)NCc2cccc(F)c2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H19ClFN3O3S/c1-14-5-8-19(25-21(27)24-13-15-3-2-4-17(23)11-15)12-20(14)30(28,29)26-18-9-6-16(22)7-10-18/h2-12,26H,13H2,1H3,(H2,24,25,27)	YJPNVFWUNAQFSR-UHFFFAOYSA-N	339501	US10202339, Compound 279	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339501	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339501&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672444	385210362							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669504	Cc1ccc(NC(=O)NCc2ccc(Cl)cc2Cl)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H18Cl3N3O3S/c1-13-2-7-18(26-21(28)25-12-14-3-4-16(23)10-19(14)24)11-20(13)31(29,30)27-17-8-5-15(22)6-9-17/h2-11,27H,12H2,1H3,(H2,25,26,28)	KETPEOULWKXAPJ-UHFFFAOYSA-N	339502	US10202339, Compound 280	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339502	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339502&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672445	385210363							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669505	Cc1cccc(CNC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)c1	InChI=1S/C22H22ClN3O3S/c1-15-4-3-5-17(12-15)14-24-22(27)25-20-9-6-16(2)21(13-20)30(28,29)26-19-10-7-18(23)8-11-19/h3-13,26H,14H2,1-2H3,(H2,24,25,27)	PURRRVJGBPJEPD-UHFFFAOYSA-N	339503	US10202339, Compound 282	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339503	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339503&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672557	385210364							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669506	Cc1ccc(CNC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)cc1	InChI=1S/C22H22ClN3O3S/c1-15-3-6-17(7-4-15)14-24-22(27)25-20-10-5-16(2)21(13-20)30(28,29)26-19-11-8-18(23)9-12-19/h3-13,26H,14H2,1-2H3,(H2,24,25,27)	IRJDARBAWFBVDD-UHFFFAOYSA-N	339504	US10202339, Compound 283	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339504	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339504&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672558	385210365							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669507	C[C@@H](NC(=O)Nc1ccc(C)c(c1)S(=O)(=O)Nc1ccc(Cl)cc1)c1ccccc1	InChI=1S/C22H22ClN3O3S/c1-15-8-11-20(25-22(27)24-16(2)17-6-4-3-5-7-17)14-21(15)30(28,29)26-19-12-9-18(23)10-13-19/h3-14,16,26H,1-2H3,(H2,24,25,27)/t16-/m1/s1	KAGAQKMVOVVXFP-MRXNPFEDSA-N	339505	US10202339, Compound 284	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339505	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339505&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145574	385210366							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669508	Cc1ccc(NC(=O)Nc2ccccc2Cc2ccccc2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C27H24ClN3O3S/c1-19-11-14-24(18-26(19)35(33,34)31-23-15-12-22(28)13-16-23)29-27(32)30-25-10-6-5-9-21(25)17-20-7-3-2-4-8-20/h2-16,18,31H,17H2,1H3,(H2,29,30,32)	VNYFUVXVVZKTKG-UHFFFAOYSA-N	339506	US10202339, Compound 285	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339506	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339506&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672560	385210367							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669509	Cc1ccc(NC(=O)NC2C[C@H]2c2ccccc2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C23H22ClN3O3S/c1-15-7-10-19(13-22(15)31(29,30)27-18-11-8-17(24)9-12-18)25-23(28)26-21-14-20(21)16-5-3-2-4-6-16/h2-13,20-21,27H,14H2,1H3,(H2,25,26,28)/t20-,21?/m0/s1	HUAARBPHGMXYOZ-BGERDNNASA-N	339507	US10202339, Compound 286	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339507	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339507&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145573	385210368							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669510	Cc1ccc(NC(=O)Nc2ccc3ccccc3c2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C24H20ClN3O3S/c1-16-6-10-22(15-23(16)32(30,31)28-20-12-8-19(25)9-13-20)27-24(29)26-21-11-7-17-4-2-3-5-18(17)14-21/h2-15,28H,1H3,(H2,26,27,29)	BKSPSHYOPCDXAT-UHFFFAOYSA-N	339508	US10202339, Compound 287	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339508	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339508&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672561	385210369							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669511	C[C@H](NC(=O)Nc1ccc(C)c(c1)S(=O)(=O)Nc1ccc(Cl)cc1)c1cccc2ccccc12	InChI=1S/C26H24ClN3O3S/c1-17-10-13-22(16-25(17)34(32,33)30-21-14-11-20(27)12-15-21)29-26(31)28-18(2)23-9-5-7-19-6-3-4-8-24(19)23/h3-16,18,30H,1-2H3,(H2,28,29,31)/t18-/m0/s1	RFGWXCYTAWWTPJ-SFHVURJKSA-N	339509	US10202339, Compound 288	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339509	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339509&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672562	385210370							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669512	Cc1ccc(NC(=O)Nc2ccsc2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C18H16ClN3O3S2/c1-12-2-5-15(20-18(23)21-16-8-9-26-11-16)10-17(12)27(24,25)22-14-6-3-13(19)4-7-14/h2-11,22H,1H3,(H2,20,21,23)	USXGCJUVFNSFDO-UHFFFAOYSA-N	339510	US10202339, Compound 289	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339510	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339510&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672679	385210371							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669513	Cc1onc(c1NC(=O)Nc1ccc(C)c(c1)S(=O)(=O)Nc1ccc(Cl)cc1)-c1ccccc1	InChI=1S/C24H21ClN4O4S/c1-15-8-11-20(14-21(15)34(31,32)29-19-12-9-18(25)10-13-19)26-24(30)27-22-16(2)33-28-23(22)17-6-4-3-5-7-17/h3-14,29H,1-2H3,(H2,26,27,30)	QSQOVTQYAHEADZ-UHFFFAOYSA-N	339511	US10202339, Compound 290	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339511	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339511&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145575	385210372							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669514	Cc1ccc(NC(=O)Nc2ccc3OCCc3c2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C22H20ClN3O4S/c1-14-2-5-19(13-21(14)31(28,29)26-17-6-3-16(23)4-7-17)25-22(27)24-18-8-9-20-15(12-18)10-11-30-20/h2-9,12-13,26H,10-11H2,1H3,(H2,24,25,27)	RBFLRDPZKFSXNX-UHFFFAOYSA-N	339512	US10202339, Compound 291	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339512	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339512&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672680	385210373							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669515	Cc1ccc(NC(=O)Nc2ccc3OCOc3c2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C21H18ClN3O5S/c1-13-2-5-17(11-20(13)31(27,28)25-15-6-3-14(22)4-7-15)24-21(26)23-16-8-9-18-19(10-16)30-12-29-18/h2-11,25H,12H2,1H3,(H2,23,24,26)	AOBWETTYBAPQMP-UHFFFAOYSA-N	339513	US10202339, Compound 292	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339513	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339513&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672681	385210374							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669516	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1ccccc1Cl	InChI=1S/C21H17ClF3N3O3S/c1-13-9-10-16(12-19(13)32(30,31)28-18-8-3-2-7-17(18)22)27-20(29)26-15-6-4-5-14(11-15)21(23,24)25/h2-12,28H,1H3,(H2,26,27,29)	QJKIHTHWERGVTK-UHFFFAOYSA-N	339514	US10202339, Compound 293	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339514	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339514&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672682	385210375							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669517	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1cccc(Cl)c1	InChI=1S/C21H17ClF3N3O3S/c1-13-8-9-17(12-19(13)32(30,31)28-18-7-3-5-15(22)11-18)27-20(29)26-16-6-2-4-14(10-16)21(23,24)25/h2-12,28H,1H3,(H2,26,27,29)	BLPGALURLBLCMX-UHFFFAOYSA-N	339515	US10202339, Compound 294	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339515	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339515&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145394	385210376							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669518	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1ccccc1F	InChI=1S/C21H17F4N3O3S/c1-13-9-10-16(12-19(13)32(30,31)28-18-8-3-2-7-17(18)22)27-20(29)26-15-6-4-5-14(11-15)21(23,24)25/h2-12,28H,1H3,(H2,26,27,29)	DGQNDGFKRVVTRS-UHFFFAOYSA-N	339516	US10202339, Compound 295	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339516	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339516&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672683	385210377							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669519	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1cccc(F)c1	InChI=1S/C21H17F4N3O3S/c1-13-8-9-17(12-19(13)32(30,31)28-18-7-3-5-15(22)11-18)27-20(29)26-16-6-2-4-14(10-16)21(23,24)25/h2-12,28H,1H3,(H2,26,27,29)	FUMLTWAKNFJGMF-UHFFFAOYSA-N	339517	US10202339, Compound 296	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339517	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339517&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672684	385210378							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669520	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1ccc(F)cc1	InChI=1S/C21H17F4N3O3S/c1-13-5-8-18(12-19(13)32(30,31)28-16-9-6-15(22)7-10-16)27-20(29)26-17-4-2-3-14(11-17)21(23,24)25/h2-12,28H,1H3,(H2,26,27,29)	YDVMDNCXFAKXOK-UHFFFAOYSA-N	339518	US10202339, Compound 297	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339518	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339518&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672803	385210379							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669521	Cc1cc(F)ccc1NS(=O)(=O)c1cc(NC(=O)Nc2cccc(c2)C(F)(F)F)ccc1C	InChI=1S/C22H19F4N3O3S/c1-13-6-8-18(28-21(30)27-17-5-3-4-15(11-17)22(24,25)26)12-20(13)33(31,32)29-19-9-7-16(23)10-14(19)2/h3-12,29H,1-2H3,(H2,27,28,30)	YIDHKYHZYZYVQM-UHFFFAOYSA-N	339519	US10202339, Compound 298	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339519	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339519&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672804	385210380							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669522	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1ccc(F)c(Cl)c1	InChI=1S/C21H16ClF4N3O3S/c1-12-5-6-15(28-20(30)27-14-4-2-3-13(9-14)21(24,25)26)11-19(12)33(31,32)29-16-7-8-18(23)17(22)10-16/h2-11,29H,1H3,(H2,27,28,30)	FYLIDTQLOBOVFB-UHFFFAOYSA-N	339520	US10202339, Compound 299	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339520	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339520&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672805	385210381							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669523	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1cc(F)c(F)cc1F	InChI=1S/C21H15F6N3O3S/c1-11-5-6-14(29-20(31)28-13-4-2-3-12(7-13)21(25,26)27)8-19(11)34(32,33)30-18-10-16(23)15(22)9-17(18)24/h2-10,30H,1H3,(H2,28,29,31)	CQTMIQDTOZHFTC-UHFFFAOYSA-N	339521	US10202339, Compound 301	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339521	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339521&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145397	385210382							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669524	Cc1cccc(NS(=O)(=O)c2cc(NC(=O)Nc3cccc(c3)C(F)(F)F)ccc2C)c1	InChI=1S/C22H20F3N3O3S/c1-14-5-3-8-19(11-14)28-32(30,31)20-13-18(10-9-15(20)2)27-21(29)26-17-7-4-6-16(12-17)22(23,24)25/h3-13,28H,1-2H3,(H2,26,27,29)	CTBVGAFXKDPIPF-UHFFFAOYSA-N	339522	US10202339, Compound 302	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339522	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339522&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672807	385210383							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669525	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1cccc(O)c1	InChI=1S/C21H18F3N3O4S/c1-13-8-9-16(12-19(13)32(30,31)27-17-6-3-7-18(28)11-17)26-20(29)25-15-5-2-4-14(10-15)21(22,23)24/h2-12,27-28H,1H3,(H2,25,26,29)	MPDPMQBINDKCAR-UHFFFAOYSA-N	339523	US10202339, Compound 303::US10202339, Compound 324	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339523	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339523&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672808	385210384							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669526	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1ccc(O)cc1	InChI=1S/C21H18F3N3O4S/c1-13-5-6-17(12-19(13)32(30,31)27-15-7-9-18(28)10-8-15)26-20(29)25-16-4-2-3-14(11-16)21(22,23)24/h2-12,27-28H,1H3,(H2,25,26,29)	MWAXFMPGVDEKIT-UHFFFAOYSA-N	339524	US10202339, Compound 304	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		<1000							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339524	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339524&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73508023	385210385							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669527	CCCOc1ccc(NS(=O)(=O)c2cc(NC(=O)Nc3cccc(c3)C(F)(F)F)ccc2C)cc1	InChI=1S/C24H24F3N3O4S/c1-3-13-34-21-11-9-18(10-12-21)30-35(32,33)22-15-20(8-7-16(22)2)29-23(31)28-19-6-4-5-17(14-19)24(25,26)27/h4-12,14-15,30H,3,13H2,1-2H3,(H2,28,29,31)	SFFYKGWFZZRWRM-UHFFFAOYSA-N	339525	US10202339, Compound 305	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339525	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339525&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672921	385210386							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669528	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1ccc(OS(C)(=O)=O)cc1	InChI=1S/C22H20F3N3O6S2/c1-14-6-7-18(27-21(29)26-17-5-3-4-15(12-17)22(23,24)25)13-20(14)36(32,33)28-16-8-10-19(11-9-16)34-35(2,30)31/h3-13,28H,1-2H3,(H2,26,27,29)	NUZQDPNHGDWFLB-UHFFFAOYSA-N	339526	US10202339, Compound 306	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339526	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339526&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672922	385210387							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669529	CCOC(=O)COc1ccc(NS(=O)(=O)c2cc(NC(=O)Nc3cccc(c3)C(F)(F)F)ccc2C)cc1	InChI=1S/C25H24F3N3O6S/c1-3-36-23(32)15-37-21-11-9-18(10-12-21)31-38(34,35)22-14-20(8-7-16(22)2)30-24(33)29-19-6-4-5-17(13-19)25(26,27)28/h4-14,31H,3,15H2,1-2H3,(H2,29,30,33)	KRMAWTFFPCHAQJ-UHFFFAOYSA-N	339527	US10202339, Compound 308	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339527	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339527&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672923	385210388							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669530	CC(=O)Nc1ccc(NS(=O)(=O)c2cc(NC(=O)Nc3cccc(c3)C(F)(F)F)ccc2C)cc1	InChI=1S/C23H21F3N4O4S/c1-14-6-7-20(29-22(32)28-19-5-3-4-16(12-19)23(24,25)26)13-21(14)35(33,34)30-18-10-8-17(9-11-18)27-15(2)31/h3-13,30H,1-2H3,(H,27,31)(H2,28,29,32)	RQJXUQZWYURDLG-UHFFFAOYSA-N	339528	US10202339, Compound 309	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339528	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339528&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672924	385210389							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669531	CCOC(=O)CNc1ccc(NS(=O)(=O)c2cc(NC(=O)Nc3cccc(c3)C(F)(F)F)ccc2C)cc1	InChI=1S/C25H25F3N4O5S/c1-3-37-23(33)15-29-18-9-11-19(12-10-18)32-38(35,36)22-14-21(8-7-16(22)2)31-24(34)30-20-6-4-5-17(13-20)25(26,27)28/h4-14,29,32H,3,15H2,1-2H3,(H2,30,31,34)	XQJBQEAHKOSEAI-UHFFFAOYSA-N	339529	US10202339, Compound 310	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339529	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339529&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672925	385210390							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669532	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1ccc(cc1)C#N	InChI=1S/C22H17F3N4O3S/c1-14-5-8-19(28-21(30)27-18-4-2-3-16(11-18)22(23,24)25)12-20(14)33(31,32)29-17-9-6-15(13-26)7-10-17/h2-12,29H,1H3,(H2,27,28,30)	VESHGQLUPXWSDC-UHFFFAOYSA-N	339530	US10202339, Compound 311	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339530	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339530&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673052	385210391							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669533	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1ccc(cc1)C(O)=O	InChI=1S/C22H18F3N3O5S/c1-13-5-8-18(27-21(31)26-17-4-2-3-15(11-17)22(23,24)25)12-19(13)34(32,33)28-16-9-6-14(7-10-16)20(29)30/h2-12,28H,1H3,(H,29,30)(H2,26,27,31)	HRTXHTLQWYLPDT-UHFFFAOYSA-N	339531	US10202339, Compound 312	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339531	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339531&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673053	385210392							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669534	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1ccc(cc1)S(C)(=O)=O	InChI=1S/C22H20F3N3O5S2/c1-14-6-7-18(27-21(29)26-17-5-3-4-15(12-17)22(23,24)25)13-20(14)35(32,33)28-16-8-10-19(11-9-16)34(2,30)31/h3-13,28H,1-2H3,(H2,26,27,29)	UDUSVHDQKCZGMI-UHFFFAOYSA-N	339532	US10202339, Compound 313	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339532	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339532&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73673054	385210393							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669535	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1cccc(CCc2ccccc2)c1	InChI=1S/C29H26F3N3O3S/c1-20-13-16-25(34-28(36)33-24-11-6-10-23(18-24)29(30,31)32)19-27(20)39(37,38)35-26-12-5-9-22(17-26)15-14-21-7-3-2-4-8-21/h2-13,16-19,35H,14-15H2,1H3,(H2,33,34,36)	KFUFPCNBPVJPEK-UHFFFAOYSA-N	339533	US10202339, Compound 314	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339533	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339533&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145396	385210394							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669536	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1ccc2OCCOc2c1	InChI=1S/C23H20F3N3O5S/c1-14-5-6-17(28-22(30)27-16-4-2-3-15(11-16)23(24,25)26)13-21(14)35(31,32)29-18-7-8-19-20(12-18)34-10-9-33-19/h2-8,11-13,29H,9-10H2,1H3,(H2,27,28,30)	SFMPUNHMSHICKA-UHFFFAOYSA-N	339534	US10202339, Compound 315	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339534	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339534&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90102064	385210395							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669537	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1ccc2cc[nH]c2c1	InChI=1S/C23H19F3N4O3S/c1-14-5-7-18(29-22(31)28-17-4-2-3-16(11-17)23(24,25)26)13-21(14)34(32,33)30-19-8-6-15-9-10-27-20(15)12-19/h2-13,27,30H,1H3,(H2,28,29,31)	CXMKWBJMTJFQLB-UHFFFAOYSA-N	339535	US10202339, Compound 316	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339535	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339535&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90101724	385210396							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669538	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1ccc2[nH]ccc2c1	InChI=1S/C23H19F3N4O3S/c1-14-5-6-18(29-22(31)28-17-4-2-3-16(12-17)23(24,25)26)13-21(14)34(32,33)30-19-7-8-20-15(11-19)9-10-27-20/h2-13,27,30H,1H3,(H2,28,29,31)	MLWHTBGNOJURJV-UHFFFAOYSA-N	339536	US10202339, Compound 317	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339536	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339536&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145454	385210397							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669539	CC(=O)n1ccc2cc(NS(=O)(=O)c3cc(NC(=O)Nc4cccc(c4)C(F)(F)F)ccc3C)ccc12	InChI=1S/C25H21F3N4O4S/c1-15-6-7-20(30-24(34)29-19-5-3-4-18(13-19)25(26,27)28)14-23(15)37(35,36)31-21-8-9-22-17(12-21)10-11-32(22)16(2)33/h3-14,31H,1-2H3,(H2,29,30,34)	GUOANNPZYWQPGQ-UHFFFAOYSA-N	339537	US10202339, Compound 318	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339537	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339537&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145455	385210398							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669540	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1ccc2[nH]cnc2c1	InChI=1S/C22H18F3N5O3S/c1-13-5-6-16(29-21(31)28-15-4-2-3-14(9-15)22(23,24)25)11-20(13)34(32,33)30-17-7-8-18-19(10-17)27-12-26-18/h2-12,30H,1H3,(H,26,27)(H2,28,29,31)	XUDHPMGLJXMZER-UHFFFAOYSA-N	339538	US10202339, Compound 319	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339538	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339538&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145456	385210399							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669541	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1ccc2n(C)cnc2c1	InChI=1S/C23H20F3N5O3S/c1-14-6-7-17(29-22(32)28-16-5-3-4-15(10-16)23(24,25)26)12-21(14)35(33,34)30-18-8-9-20-19(11-18)27-13-31(20)2/h3-13,30H,1-2H3,(H2,28,29,32)	QPFTXEOXUWJYIC-UHFFFAOYSA-N	339539	US10202339, Compound 320	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339539	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339539&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90101840	385210400							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669542	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1cccc2ncccc12	InChI=1S/C24H19F3N4O3S/c1-15-10-11-18(30-23(32)29-17-6-2-5-16(13-17)24(25,26)27)14-22(15)35(33,34)31-21-9-3-8-20-19(21)7-4-12-28-20/h2-14,31H,1H3,(H2,29,30,32)	RFMRYMXZOWDMHY-UHFFFAOYSA-N	339540	US10202339, Compound 321	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339540	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339540&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145457	385210401							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669543	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1ccc(cc1)-c1nn[nH]n1	InChI=1S/C22H18F3N7O3S/c1-13-5-8-18(27-21(33)26-17-4-2-3-15(11-17)22(23,24)25)12-19(13)36(34,35)30-16-9-6-14(7-10-16)20-28-31-32-29-20/h2-12,30H,1H3,(H2,26,27,33)(H,28,29,31,32)	JVXLMXGFLNLCBF-UHFFFAOYSA-N	339541	US10202339, Compound 322	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339541	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339541&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145452	385210402							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669544	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)N1CCNCC1	InChI=1S/C19H21F3N4O3S/c1-13-5-6-16(12-17(13)30(28,29)26-9-7-23-8-10-26)25-18(27)24-15-4-2-3-14(11-15)19(20,21)22/h2-6,11-12,23H,7-10H2,1H3,(H2,24,25,27)	RASDPUMMGPFPTP-UHFFFAOYSA-N	339542	US10202339, Compound 323	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339542	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339542&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145453	385210403							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669545	Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1cccc(O)c1	InChI=1S/C21H18F3N3O4S/c1-13-8-9-16(12-19(13)32(30,31)27-17-6-3-7-18(28)11-17)26-20(29)25-15-5-2-4-14(10-15)21(22,23)24/h2-12,27-28H,1H3,(H2,25,26,29)	MPDPMQBINDKCAR-UHFFFAOYSA-N	339523	US10202339, Compound 303::US10202339, Compound 324	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339523	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339523&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			73672808	385210384							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669546	CCOC(=O)COc1ccc(NS(=O)(=O)c2cc(NC(=O)Nc3ccc(cc3)C(F)(F)F)ccc2C)cc1	InChI=1S/C25H24F3N3O6S/c1-3-36-23(32)15-37-21-12-10-19(11-13-21)31-38(34,35)22-14-20(7-4-16(22)2)30-24(33)29-18-8-5-17(6-9-18)25(26,27)28/h4-14,31H,3,15H2,1-2H3,(H2,29,30,33)	WJOTVMSLGKWBNW-UHFFFAOYSA-N	339544	US10202339, Compound 325	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339544	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339544&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137483111	385210404							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669547	Cc1ccc(NC(=O)Nc2ccc(cc2)C(F)(F)F)cc1S(=O)(=O)Nc1ccc(OCC(O)=O)cc1	InChI=1S/C23H20F3N3O6S/c1-14-2-5-18(28-22(32)27-16-6-3-15(4-7-16)23(24,25)26)12-20(14)36(33,34)29-17-8-10-19(11-9-17)35-13-21(30)31/h2-12,29H,13H2,1H3,(H,30,31)(H2,27,28,32)	ORFKDNSINKHLAR-UHFFFAOYSA-N	339545	US10202339, Compound 326	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339545	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339545&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137483134	385210405							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669548	Cc1ccc(NC(=O)Nc2ccc(cc2)C(F)(F)F)cc1S(=O)(=O)Nc1ccc(OS(C)(=O)=O)cc1	InChI=1S/C22H20F3N3O6S2/c1-14-3-6-18(27-21(29)26-16-7-4-15(5-8-16)22(23,24)25)13-20(14)36(32,33)28-17-9-11-19(12-10-17)34-35(2,30)31/h3-13,28H,1-2H3,(H2,26,27,29)	WGCCSEZWRZCMAB-UHFFFAOYSA-N	339546	US10202339, Compound 327	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339546	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339546&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137483090	385210406							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669549	CCOC(=O)C(C)Oc1ccc(NS(=O)(=O)c2cc(NC(=O)Nc3ccc(cc3)C(F)(F)F)ccc2C)cc1	InChI=1S/C26H26F3N3O6S/c1-4-37-24(33)17(3)38-22-13-11-20(12-14-22)32-39(35,36)23-15-21(8-5-16(23)2)31-25(34)30-19-9-6-18(7-10-19)26(27,28)29/h5-15,17,32H,4H2,1-3H3,(H2,30,31,34)	AKGAMZOEVFVUTR-UHFFFAOYSA-N	339547	US10202339, Compound 328	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339547	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339547&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137483095	385210407							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669550	CC(=O)Nc1ccc(NS(=O)(=O)c2cc(NC(=O)Nc3ccc(cc3)C(F)(F)F)ccc2C)cc1	InChI=1S/C23H21F3N4O4S/c1-14-3-6-20(29-22(32)28-18-7-4-16(5-8-18)23(24,25)26)13-21(14)35(33,34)30-19-11-9-17(10-12-19)27-15(2)31/h3-13,30H,1-2H3,(H,27,31)(H2,28,29,32)	YSGRBZUURVOMLS-UHFFFAOYSA-N	339548	US10202339, Compound 329	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339548	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339548&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137483088	385210408							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669551	CCOC(=O)CNc1ccc(NS(=O)(=O)c2cc(NC(=O)Nc3ccc(cc3)C(F)(F)F)ccc2C)cc1	InChI=1S/C25H25F3N4O5S/c1-3-37-23(33)15-29-18-10-12-20(13-11-18)32-38(35,36)22-14-21(7-4-16(22)2)31-24(34)30-19-8-5-17(6-9-19)25(26,27)28/h4-14,29,32H,3,15H2,1-2H3,(H2,30,31,34)	IBVVRVKJWQFFJI-UHFFFAOYSA-N	339549	US10202339, Compound 330	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339549	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339549&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137483135	385210409							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669552	Cc1ccc(NC(=O)Nc2ccc(cc2)C(F)(F)F)cc1S(=O)(=O)Nc1ccc(cc1)S(C)(=O)=O	InChI=1S/C22H20F3N3O5S2/c1-14-3-6-18(27-21(29)26-16-7-4-15(5-8-16)22(23,24)25)13-20(14)35(32,33)28-17-9-11-19(12-10-17)34(2,30)31/h3-13,28H,1-2H3,(H2,26,27,29)	CNWZFWVVAYIFPG-UHFFFAOYSA-N	339550	US10202339, Compound 331	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339550	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339550&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137483112	385210410							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669553	Cc1ccc(NC(=O)Nc2ccc(cc2)C(F)(F)F)cc1S(=O)(=O)Nc1cccc(CCc2ccccc2)c1	InChI=1S/C29H26F3N3O3S/c1-20-10-15-25(34-28(36)33-24-16-13-23(14-17-24)29(30,31)32)19-27(20)39(37,38)35-26-9-5-8-22(18-26)12-11-21-6-3-2-4-7-21/h2-10,13-19,35H,11-12H2,1H3,(H2,33,34,36)	KXVHIVMYWGTOCN-UHFFFAOYSA-N	339551	US10202339, Compound 332	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339551	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339551&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137483097	385210411							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669554	CCc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C22H19ClF3N3O3S/c1-2-14-6-9-19(13-20(14)33(31,32)29-17-10-7-16(23)8-11-17)28-21(30)27-18-5-3-4-15(12-18)22(24,25)26/h3-13,29H,2H2,1H3,(H2,27,28,30)	HHRWHBUAHYJBBU-UHFFFAOYSA-N	339552	US10202339, Compound 333	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339552	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339552&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145578	385210412							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669555	Cc1ccc(NC(=O)Nc2cccc(c2)S(=O)(=O)Nc2ccccc2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C26H23ClN4O5S2/c1-18-10-13-23(17-25(18)38(35,36)31-21-14-11-19(27)12-15-21)29-26(32)28-22-8-5-9-24(16-22)37(33,34)30-20-6-3-2-4-7-20/h2-17,30-31H,1H3,(H2,28,29,32)	SPWSKRGHSFWEJT-UHFFFAOYSA-N	339553	US10202339, Compound 334	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339553	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339553&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145579	385210413							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669556	Cc1ccc(NC(=O)Nc2cccc(c2)S(=O)(=O)Nc2ccc(Cl)cc2)cc1S(=O)(=O)Nc1ccccc1	InChI=1S/C26H23ClN4O5S2/c1-18-10-13-23(17-25(18)38(35,36)31-20-6-3-2-4-7-20)29-26(32)28-22-8-5-9-24(16-22)37(33,34)30-21-14-11-19(27)12-15-21/h2-17,30-31H,1H3,(H2,28,29,32)	XNOFJCQOJFSTCG-UHFFFAOYSA-N	339554	US10202339, Compound 335	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339554	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339554&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124031401	385210414							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669557	Cc1ccc(NC(=O)Nc2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)cc1S(=O)(=O)Nc1ccc(Cl)cc1	InChI=1S/C27H24Cl2N4O5S2/c1-17-3-9-23(15-25(17)39(35,36)32-21-11-5-19(28)6-12-21)30-27(34)31-24-10-4-18(2)26(16-24)40(37,38)33-22-13-7-20(29)8-14-22/h3-16,32-33H,1-2H3,(H2,30,31,34)	UPALHXOXRMEQRS-UHFFFAOYSA-N	339555	US10202339, Compound 336	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339555	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339555&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90145577	385210415							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
669558	FC(F)(F)c1cccc(NC(=O)Nc2cc(ccc2-c2ccsc2)S(=O)(=O)Nc2ccccc2)c1	InChI=1S/C24H18F3N3O3S2/c25-24(26,27)17-5-4-8-19(13-17)28-23(31)29-22-14-20(9-10-21(22)16-11-12-34-15-16)35(32,33)30-18-6-2-1-3-7-18/h1-15,30H,(H2,28,29,31)	UIJSXEOJNPJHOP-UHFFFAOYSA-N	339556	N-phenyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoromethyl)phenyl)ureido)benzenesulfonamide::US10202339, Compound 351	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Human		 5500							US Patent		10.7270/Q25M67VR		aid1797127	US10202339	Popovici-Muller, J; Salituro, FG; Saunders, JO; Travins, J; Yan, S	2/12/2019	7/22/2019	Agios Pharmaceuticals Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=339556	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=339556&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			90101216	385210416							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	3INM,3MAP,3MAR,3MAS,4I3K,4I3L,4KZO,4UMX,4UMY,4XRX,4XS3,5DE1,5LGE,5SUN,5SVF,5TQH,6ADG,6B0Z,6O2Y,6O2Z,6Q6F,6U4J,6VEI,6VG0	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719729	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncccn1 |r|	InChI=1S/C27H23ClF3N5O3/c28-20-8-2-1-7-19(20)23(24(38)34-17-14-27(30,31)15-17)35(18-6-3-5-16(29)13-18)25(39)21-9-10-22(37)36(21)26-32-11-4-12-33-26/h1-8,11-13,17,21,23H,9-10,14-15H2,(H,34,38)	XEHAZACRPFRAJJ-UHFFFAOYSA-N	363504	US9850277, Compound 1::US10689414, Compound 1::US10640534, Compound 1::US10717764, Compound 1::US11021515, Compound 1::US11667673, Compound 1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363504&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71620855	401958958							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719731	CN1[C@@H](CCC1=O)C(=O)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C24H23ClF3N3O3/c1-30-19(9-10-20(30)32)23(34)31(16-6-4-5-14(26)11-16)21(17-7-2-3-8-18(17)25)22(33)29-15-12-24(27,28)13-15/h2-8,11,15,19,21H,9-10,12-13H2,1H3,(H,29,33)	WTODWBLYOUDTID-UHFFFAOYSA-N	363509	US9850277, Compound 2::US10689414, Compound 2::US10640534, Compound 2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363509&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707825	401958962							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719733	Fc1cccc(c1)N([C@@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)C1CCC(=O)N1c1ncccn1 |r|	InChI=1S/C29H27ClF3N5O3/c30-22-8-2-1-7-21(22)25(26(40)36-19-11-13-29(32,33)14-12-19)37(20-6-3-5-18(31)17-20)27(41)23-9-10-24(39)38(23)28-34-15-4-16-35-28/h1-8,15-17,19,23,25H,9-14H2,(H,36,40)	NTMQXDPSVIDVCI-UHFFFAOYSA-N	363510	US9850277, Compound 3::US10689414, Compound 3::US10640534, Compound 3::US10717764, Compound 3::US11021515, Compound 3::US11667673, Compound 3	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363510&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699661	401958963							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719735	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)C1CCC(=O)N1c1ncccn1 |r|	InChI=1S/C29H27ClF3N5O3/c30-22-8-2-1-7-21(22)25(26(40)36-19-11-13-29(32,33)14-12-19)37(20-6-3-5-18(31)17-20)27(41)23-9-10-24(39)38(23)28-34-15-4-16-35-28/h1-8,15-17,19,23,25H,9-14H2,(H,36,40)	NTMQXDPSVIDVCI-UHFFFAOYSA-N	363511	US9850277, Compound 4::US10689414, Compound 4::US10640534, Compound 4::US10717764, Compound 4::US11021515, Compound 4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363511	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363511&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699550	401958964							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719737	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ccccn1 |r|	InChI=1S/C28H24ClF3N4O3/c29-21-9-2-1-8-20(21)25(26(38)34-18-15-28(31,32)16-18)35(19-7-5-6-17(30)14-19)27(39)22-11-12-24(37)36(22)23-10-3-4-13-33-23/h1-10,13-14,18,22,25H,11-12,15-16H2,(H,34,38)	BNMZIPHBCZHHSG-UHFFFAOYSA-N	363512	US9850277, Compound 5::US10689414, Compound 5::US10640534, Compound 5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363512&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707827	401958965							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719739	Fc1cccc(c1)N([C@@H](C(=O)NC1CCCCC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncccn1 |r|	InChI=1S/C29H29ClFN5O3/c30-23-13-5-4-12-22(23)26(27(38)34-20-9-2-1-3-10-20)35(21-11-6-8-19(31)18-21)28(39)24-14-15-25(37)36(24)29-32-16-7-17-33-29/h4-8,11-13,16-18,20,24,26H,1-3,9-10,14-15H2,(H,34,38)	WDEWUONHJCNHPC-UHFFFAOYSA-N	363513	US9850277, Compound 6::US10689414, Compound 6::US10640534, Compound 6::US11021515, Compound 6::US11667673, Compound 6	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363513&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707826	401958966							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719741	Fc1cccc(c1)N([C@H](C(=O)NC1CCCCC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncccn1 |r|	InChI=1S/C29H29ClFN5O3/c30-23-13-5-4-12-22(23)26(27(38)34-20-9-2-1-3-10-20)35(21-11-6-8-19(31)18-21)28(39)24-14-15-25(37)36(24)29-32-16-7-17-33-29/h4-8,11-13,16-18,20,24,26H,1-3,9-10,14-15H2,(H,34,38)	WDEWUONHJCNHPC-UHFFFAOYSA-N	363514	US9850277, Compound 7::US10689414, Compound 7::US10640534, Compound 7::US10717764, Compound 7::US11021515, Compound 7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363514&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707828	401958967							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719743	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1ncccn1 |r|	InChI=1S/C26H21ClF3N5O4/c27-19-8-2-1-7-18(19)21(22(36)33-16-12-26(29,30)13-16)34(17-6-3-5-15(28)11-17)23(37)20-14-39-25(38)35(20)24-31-9-4-10-32-24/h1-11,16,20-21H,12-14H2,(H,33,36)	DGNVKHSKMRTWAV-UHFFFAOYSA-N	363515	US9850277, Compound 8::US10689414, Compound 8::US10640534, Compound 8::US10717764, Compound 8::US11021515, Compound 8::US11667673, Compound 8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>3000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363515&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86690596	401958968							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719745	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1ncccn1 |r|	InChI=1S/C26H21ClF3N5O4/c27-19-8-2-1-7-18(19)21(22(36)33-16-12-26(29,30)13-16)34(17-6-3-5-15(28)11-17)23(37)20-14-39-25(38)35(20)24-31-9-4-10-32-24/h1-11,16,20-21H,12-14H2,(H,33,36)	DGNVKHSKMRTWAV-UHFFFAOYSA-N	363516	US9850277, Compound 9::US10689414, Compound 9::US10640534, Compound 9::US10717764, Compound 9::US11021515, Compound 9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363516&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699850	401958969							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719747	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cccnc1 |r|	InChI=1S/C28H24ClF3N4O3/c29-22-9-2-1-8-21(22)25(26(38)34-18-14-28(31,32)15-18)36(19-6-3-5-17(30)13-19)27(39)23-10-11-24(37)35(23)20-7-4-12-33-16-20/h1-9,12-13,16,18,23,25H,10-11,14-15H2,(H,34,38)	UMLWDDXKOCBRGN-UHFFFAOYSA-N	363518	US9850277, Compound 10::US10689414, Compound 10::US10640534, Compound 10::US10717764, Compound 10::US11021515, Compound 10	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363518&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707829	401958971							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719749	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cccc(F)n1 |r|	InChI=1S/C28H23ClF4N4O3/c29-20-8-2-1-7-19(20)25(26(39)34-17-14-28(32,33)15-17)36(18-6-3-5-16(30)13-18)27(40)21-11-12-24(38)37(21)23-10-4-9-22(31)35-23/h1-10,13,17,21,25H,11-12,14-15H2,(H,34,39)	VOKYMLJKRXOWSX-UHFFFAOYSA-N	363519	US9850277, Compound 11::US10689414, Compound 11::US10640534, Compound 11::US10717764, Compound 11::US11021515, Compound 11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363519&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707830	401958972							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719751	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncccc1F |r|	InChI=1S/C28H23ClF4N4O3/c29-20-8-2-1-7-19(20)24(26(39)35-17-14-28(32,33)15-17)36(18-6-3-5-16(30)13-18)27(40)22-10-11-23(38)37(22)25-21(31)9-4-12-34-25/h1-9,12-13,17,22,24H,10-11,14-15H2,(H,35,39)	GHHXPAIKTCHCIO-UHFFFAOYSA-N	363520	US9850277, Compound 12::US10689414, Compound 12::US10640534, Compound 12::US10717764, Compound 12	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363520&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707832	401958973							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719753	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccs1 |r|	InChI=1S/C26H22ClF3N4O3S/c27-19-7-2-1-6-18(19)22(23(36)32-16-13-26(29,30)14-16)33(17-5-3-4-15(28)12-17)24(37)20-8-9-21(35)34(20)25-31-10-11-38-25/h1-7,10-12,16,20,22H,8-9,13-14H2,(H,32,36)	HAHDJLUASRMCOO-UHFFFAOYSA-N	363521	US9850277, Compound 13::US10689414, Compound 13::US10640534, Compound 13::US10717764, Compound 13::US11021515, Compound 13::US11667673, Compound 13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>3000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363521&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707831	401958974							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719755	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccs1 |r|	InChI=1S/C26H22ClF3N4O3S/c27-19-7-2-1-6-18(19)22(23(36)32-16-13-26(29,30)14-16)33(17-5-3-4-15(28)12-17)24(37)20-8-9-21(35)34(20)25-31-10-11-38-25/h1-7,10-12,16,20,22H,8-9,13-14H2,(H,32,36)	HAHDJLUASRMCOO-UHFFFAOYSA-N	363522	US9850277, Compound 14::US10689414, Compound 14::US10640534, Compound 14::US10717764, Compound 14::US11021515, Compound 14::US11667673, Compound 14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363522&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707834	401958975							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719757	Cc1cccnc1N1[C@@H](CCC1=O)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H26ClF3N4O3/c1-17-6-5-13-34-26(17)37-23(11-12-24(37)38)28(40)36(20-8-4-7-18(31)14-20)25(21-9-2-3-10-22(21)30)27(39)35-19-15-29(32,33)16-19/h2-10,13-14,19,23,25H,11-12,15-16H2,1H3,(H,35,39)	SITQEJPACKGZEU-UHFFFAOYSA-N	363523	US9850277, Compound 15::US10689414, Compound 15::US10640534, Compound 15::US10717764, Compound 15::US11021515, Compound 15::US11667673, Compound 15	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363523	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363523&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707833	401958976							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719759	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc2ccccc12 |r|	InChI=1S/C32H26ClF3N4O3/c33-25-11-4-3-10-24(25)28(30(42)38-21-17-32(35,36)18-21)39(22-8-5-7-20(34)16-22)31(43)26-12-13-27(41)40(26)29-23-9-2-1-6-19(23)14-15-37-29/h1-11,14-16,21,26,28H,12-13,17-18H2,(H,38,42)	UTMYJGCWNXATLI-UHFFFAOYSA-N	363524	US9850277, Compound 16::US10689414, Compound 16::US10640534, Compound 16::US10717764, Compound 16::US11021515, Compound 16::US11667673, Compound 16	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363524	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363524&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707836	401958977							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719761	COc1cccnc1N1[C@@H](CCC1=O)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H26ClF3N4O4/c1-41-23-10-5-13-34-26(23)37-22(11-12-24(37)38)28(40)36(19-7-4-6-17(31)14-19)25(20-8-2-3-9-21(20)30)27(39)35-18-15-29(32,33)16-18/h2-10,13-14,18,22,25H,11-12,15-16H2,1H3,(H,35,39)	ZFVSKCAAVXOSBL-UHFFFAOYSA-N	363525	US9850277, Compound 17::US10689414, Compound 17::US10640534, Compound 17::US10717764, Compound 17::US11021515, Compound 17::US11667673, Compound 17	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363525&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707835	401958978							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719763	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cnccn1 |r|	InChI=1S/C27H23ClF3N5O3/c28-20-7-2-1-6-19(20)24(25(38)34-17-13-27(30,31)14-17)35(18-5-3-4-16(29)12-18)26(39)21-8-9-23(37)36(21)22-15-32-10-11-33-22/h1-7,10-12,15,17,21,24H,8-9,13-14H2,(H,34,38)	XRYKKBGVCNAGKT-UHFFFAOYSA-N	363526	US9850277, Compound 18::US10689414, Compound 18::US10717764, Compound 18::US11667673, Compound 18	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363526&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707837	401958979							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719765	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCCC(=O)N1c1ncccn1 |r|	InChI=1S/C28H25ClF3N5O3/c29-21-9-2-1-8-20(21)24(25(39)35-18-15-28(31,32)16-18)36(19-7-3-6-17(30)14-19)26(40)22-10-4-11-23(38)37(22)27-33-12-5-13-34-27/h1-3,5-9,12-14,18,22,24H,4,10-11,15-16H2,(H,35,39)	SBKILLKIGMRENY-UHFFFAOYSA-N	363527	US9850277, Compound 19::US10689414, Compound 19::US10640534, Compound 19::US10717764, Compound 19::US11021515, Compound 19::US11667673, Compound 19	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>3000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363527&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699539	401958980							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719767	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCCC(=O)N1c1ncccn1 |r|	InChI=1S/C28H25ClF3N5O3/c29-21-9-2-1-8-20(21)24(25(39)35-18-15-28(31,32)16-18)36(19-7-3-6-17(30)14-19)26(40)22-10-4-11-23(38)37(22)27-33-12-5-13-34-27/h1-3,5-9,12-14,18,22,24H,4,10-11,15-16H2,(H,35,39)	SBKILLKIGMRENY-UHFFFAOYSA-N	363528	US9850277, Compound 20::US10689414, Compound 20::US10640534, Compound 20::US10717764, Compound 20::US11021515, Compound 20::US11667673, Compound 20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363528&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699424	401958981							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719769	Cc1ccc(nc1)N1[C@@H](CCC1=O)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H26ClF3N4O3/c1-17-9-11-24(34-16-17)37-23(10-12-25(37)38)28(40)36(20-6-4-5-18(31)13-20)26(21-7-2-3-8-22(21)30)27(39)35-19-14-29(32,33)15-19/h2-9,11,13,16,19,23,26H,10,12,14-15H2,1H3,(H,35,39)	CYFBHINCADEEHB-UHFFFAOYSA-N	363529	US9850277, Compound 21::US10689414, Compound 21::US10640534, Compound 21::US10717764, Compound 21::US11021515, Compound 21::US11667673, Compound 21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363529&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707839	401958982							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719771	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ccncn1 |r|	InChI=1S/C27H23ClF3N5O3/c28-20-7-2-1-6-19(20)24(25(38)34-17-13-27(30,31)14-17)35(18-5-3-4-16(29)12-18)26(39)21-8-9-23(37)36(21)22-10-11-32-15-33-22/h1-7,10-12,15,17,21,24H,8-9,13-14H2,(H,34,38)	PIGGPXXOZCYULW-UHFFFAOYSA-N	363530	US9850277, Compound 22::US10689414, Compound 22::US10640534, Compound 22::US10717764, Compound 22::US11021515, Compound 22::US11667673, Compound 22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363530&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707840	401958983							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719773	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ccccc1 |r|	InChI=1S/C29H25ClF3N3O3/c30-23-12-5-4-11-22(23)26(27(38)34-19-16-29(32,33)17-19)36(21-10-6-7-18(31)15-21)28(39)24-13-14-25(37)35(24)20-8-2-1-3-9-20/h1-12,15,19,24,26H,13-14,16-17H2,(H,34,38)	ZGAOYVSEPPLYRQ-UHFFFAOYSA-N	363531	US9850277, Compound 23::US10689414, Compound 23::US10640534, Compound 23::US10717764, Compound 23	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363531&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707841	401958984							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719775	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cccc(n1)C(F)(F)F |r|	InChI=1S/C29H23ClF6N4O3/c30-20-8-2-1-7-19(20)25(26(42)37-17-14-28(32,33)15-17)39(18-6-3-5-16(31)13-18)27(43)21-11-12-24(41)40(21)23-10-4-9-22(38-23)29(34,35)36/h1-10,13,17,21,25H,11-12,14-15H2,(H,37,42)	PWTYTETZLNPWSK-UHFFFAOYSA-N	363532	US9850277, Compound 24::US10689414, Compound 24::US10640534, Compound 24::US10717764, Compound 24::US11021515, Compound 24::US11667673, Compound 24	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363532	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363532&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707842	401958985							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719777	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cccc(n1)C(F)(F)F |r|	InChI=1S/C29H23ClF6N4O3/c30-20-8-2-1-7-19(20)25(26(42)37-17-14-28(32,33)15-17)39(18-6-3-5-16(31)13-18)27(43)21-11-12-24(41)40(21)23-10-4-9-22(38-23)29(34,35)36/h1-10,13,17,21,25H,11-12,14-15H2,(H,37,42)	PWTYTETZLNPWSK-UHFFFAOYSA-N	363533	US9850277, Compound 25::US10689414, Compound 25::US10640534, Compound 25::US10717764, Compound 25::US11021515, Compound 25::US11667673, Compound 25	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>3000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363533&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707843	401958986							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719779	COc1ccc(nc1)N1[C@@H](CCC1=O)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H26ClF3N4O4/c1-41-20-9-11-24(34-16-20)37-23(10-12-25(37)38)28(40)36(19-6-4-5-17(31)13-19)26(21-7-2-3-8-22(21)30)27(39)35-18-14-29(32,33)15-18/h2-9,11,13,16,18,23,26H,10,12,14-15H2,1H3,(H,35,39)	XZOZVXRAZQWLDW-UHFFFAOYSA-N	363534	US9850277, Compound 26::US10689414, Compound 26::US10640534, Compound 26::US10717764, Compound 26::US11021515, Compound 26::US11667673, Compound 26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363534&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707844	401958987							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719781	Cc1ccnc(c1)N1[C@@H](CCC1=O)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H26ClF3N4O3/c1-17-11-12-34-24(13-17)37-23(9-10-25(37)38)28(40)36(20-6-4-5-18(31)14-20)26(21-7-2-3-8-22(21)30)27(39)35-19-15-29(32,33)16-19/h2-8,11-14,19,23,26H,9-10,15-16H2,1H3,(H,35,39)	AROXJRALBXVLMA-UHFFFAOYSA-N	363535	US9850277, Compound 27::US10689414, Compound 27::US10640534, Compound 27::US10717764, Compound 27::US11021515, Compound 27::US11667673, Compound 27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363535	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363535&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707845	401958988							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719783	Cc1cccc(n1)N1[C@@H](CCC1=O)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H26ClF3N4O3/c1-17-6-4-11-24(34-17)37-23(12-13-25(37)38)28(40)36(20-8-5-7-18(31)14-20)26(21-9-2-3-10-22(21)30)27(39)35-19-15-29(32,33)16-19/h2-11,14,19,23,26H,12-13,15-16H2,1H3,(H,35,39)	CGJBPVMJDOSEKZ-UHFFFAOYSA-N	363536	US9850277, Compound 28::US10689414, Compound 28::US10640534, Compound 28::US10717764, Compound 28::US11021515, Compound 28::US11667673, Compound 28	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363536	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363536&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707846	401958989							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719785	Fc1ccc(nc1)N1[C@@H](CCC1=O)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C28H23ClF4N4O3/c29-21-7-2-1-6-20(21)25(26(39)35-18-13-28(32,33)14-18)36(19-5-3-4-16(30)12-19)27(40)22-9-11-24(38)37(22)23-10-8-17(31)15-34-23/h1-8,10,12,15,18,22,25H,9,11,13-14H2,(H,35,39)	SOWPYWCTKWCMFB-UHFFFAOYSA-N	363537	US9850277, Compound 29::US10689414, Compound 29::US10640534, Compound 29::US10717764, Compound 29::US11021515, Compound 29::US11667673, Compound 29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363537&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707847	401958990							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719787	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1COCC(=O)N1c1ncccn1 |r|	InChI=1S/C27H23ClF3N5O4/c28-20-8-2-1-7-19(20)23(24(38)34-17-12-27(30,31)13-17)35(18-6-3-5-16(29)11-18)25(39)21-14-40-15-22(37)36(21)26-32-9-4-10-33-26/h1-11,17,21,23H,12-15H2,(H,34,38)	WHTZBGLMWBVRDT-UHFFFAOYSA-N	363538	US9850277, Compound 30::US10689414, Compound 30::US10640534, Compound 30::US10717764, Compound 30::US11021515, Compound 30::US11667673, Compound 30	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363538&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707849	401958991							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719789	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ccc(cn1)C(F)(F)F |r|	InChI=1S/C29H23ClF6N4O3/c30-21-7-2-1-6-20(21)25(26(42)38-18-13-28(32,33)14-18)39(19-5-3-4-17(31)12-19)27(43)22-9-11-24(41)40(22)23-10-8-16(15-37-23)29(34,35)36/h1-8,10,12,15,18,22,25H,9,11,13-14H2,(H,38,42)	NDUOCLRZDKMNMX-UHFFFAOYSA-N	363539	US9850277, Compound 31::US10689414, Compound 31::US10640534, Compound 31::US10717764, Compound 31::US11021515, Compound 31::US11667673, Compound 31	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363539	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363539&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707850	401958992							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719791	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(Cl)ccn1 |r|	InChI=1S/C28H23Cl2F3N4O3/c29-16-10-11-34-23(12-16)37-22(8-9-24(37)38)27(40)36(19-5-3-4-17(31)13-19)25(20-6-1-2-7-21(20)30)26(39)35-18-14-28(32,33)15-18/h1-7,10-13,18,22,25H,8-9,14-15H2,(H,35,39)	GRRXZSNAFJEVHD-UHFFFAOYSA-N	363540	US9850277, Compound 32::US10689414, Compound 32::US10640534, Compound 32::US10717764, Compound 32::US11021515, Compound 32::US11667673, Compound 32	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363540&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707851	401958993							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719793	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(Cl)ccn1 |r|	InChI=1S/C28H23Cl2F3N4O3/c29-16-10-11-34-23(12-16)37-22(8-9-24(37)38)27(40)36(19-5-3-4-17(31)13-19)25(20-6-1-2-7-21(20)30)26(39)35-18-14-28(32,33)15-18/h1-7,10-13,18,22,25H,8-9,14-15H2,(H,35,39)	GRRXZSNAFJEVHD-UHFFFAOYSA-N	363541	US9850277, Compound 33::US10689414, Compound 33::US10640534, Compound 33::US10717764, Compound 33::US11021515, Compound 33::US11667673, Compound 33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363541&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707852	401958994							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719795	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cccc(Cl)n1 |r|	InChI=1S/C28H23Cl2F3N4O3/c29-20-8-2-1-7-19(20)25(26(39)34-17-14-28(32,33)15-17)36(18-6-3-5-16(31)13-18)27(40)21-11-12-24(38)37(21)23-10-4-9-22(30)35-23/h1-10,13,17,21,25H,11-12,14-15H2,(H,34,39)	KGVKTOYOZORCGW-UHFFFAOYSA-N	363542	US9850277, Compound 34::US10689414, Compound 34::US10640534, Compound 34::US10717764, Compound 34::US11021515, Compound 34::US11667673, Compound 34	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363542	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363542&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707853	401958995							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719797	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cccc(Cl)n1 |r|	InChI=1S/C28H23Cl2F3N4O3/c29-20-8-2-1-7-19(20)25(26(39)34-17-14-28(32,33)15-17)36(18-6-3-5-16(31)13-18)27(40)21-11-12-24(38)37(21)23-10-4-9-22(30)35-23/h1-10,13,17,21,25H,11-12,14-15H2,(H,34,39)	KGVKTOYOZORCGW-UHFFFAOYSA-N	363543	US9850277, Compound 35::US10689414, Compound 35::US10640534, Compound 35::US10717764, Compound 35::US11021515, Compound 35::US11667673, Compound 35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363543&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707854	401958996							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719799	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H23ClF3N5O3/c30-22-7-2-1-6-21(22)26(27(40)36-19-14-29(32,33)15-19)37(20-5-3-4-18(31)13-20)28(41)23-8-9-25(39)38(23)24-12-17(16-34)10-11-35-24/h1-7,10-13,19,23,26H,8-9,14-15H2,(H,36,40)	LVTAMMPAQQMIPZ-UHFFFAOYSA-N	363544	US9850277, Compound 36::US10689414, Compound 36::US10640534, Compound 54::US10717764, Compound 36::US11021515, Compound 36::US11667673, Compound 54	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363544&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89708744	401958997							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719801	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H23ClF3N5O3/c30-22-7-2-1-6-21(22)26(27(40)36-19-14-29(32,33)15-19)37(20-5-3-4-18(31)13-20)28(41)23-8-9-25(39)38(23)24-12-17(16-34)10-11-35-24/h1-7,10-13,19,23,26H,8-9,14-15H2,(H,36,40)	LVTAMMPAQQMIPZ-UHFFFAOYSA-N	363545	US9850277, Compound 37::US9850277, Compound 64::US10689414, Compound 64::US10640534, Compound 64::US10717764, Compound 64::US11021515, Compound 64::US11667673, Compound 64	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363545&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89700075	401958998							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719803	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cccc(n1)C#N |r|	InChI=1S/C29H23ClF3N5O3/c30-22-9-2-1-8-21(22)26(27(40)36-19-14-29(32,33)15-19)37(20-7-3-5-17(31)13-20)28(41)23-11-12-25(39)38(23)24-10-4-6-18(16-34)35-24/h1-10,13,19,23,26H,11-12,14-15H2,(H,36,40)	NVRVZFIFEQNQRO-UHFFFAOYSA-N	363546	US9850277, Compound 38::US10689414, Compound 38::US10640534, Compound 38::US10717764, Compound 38::US11021515, Compound 38::US11667673, Compound 38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363546	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363546&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89708745	401958999							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719805	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C(F)(F)F |r|	InChI=1S/C29H23ClF6N4O3/c30-21-7-2-1-6-20(21)25(26(42)38-18-14-28(32,33)15-18)39(19-5-3-4-17(31)13-19)27(43)22-8-9-24(41)40(22)23-12-16(10-11-37-23)29(34,35)36/h1-7,10-13,18,22,25H,8-9,14-15H2,(H,38,42)	ZPVRDYRLRGZBHU-UHFFFAOYSA-N	363547	US9850277, Compound 39::US10689414, Compound 39::US10640534, Compound 39::US10717764, Compound 39::US11021515, Compound 39::US11667673, Compound 39	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363547	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363547&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89708748	401959000							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719807	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C(F)(F)F |r|	InChI=1S/C29H23ClF6N4O3/c30-21-7-2-1-6-20(21)25(26(42)38-18-14-28(32,33)15-18)39(19-5-3-4-17(31)13-19)27(43)22-8-9-24(41)40(22)23-12-16(10-11-37-23)29(34,35)36/h1-7,10-13,18,22,25H,8-9,14-15H2,(H,38,42)	ZPVRDYRLRGZBHU-UHFFFAOYSA-N	363548	US9850277, Compound 40::US10689414, Compound 40::US10640534, Compound 40::US10717764, Compound 40::US11021515, Compound 40::US11667673, Compound 40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363548&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89708772	401959001							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719809	COc1cccc(n1)N1[C@@H](CCC1=O)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H26ClF3N4O4/c1-41-24-11-5-10-23(35-24)37-22(12-13-25(37)38)28(40)36(19-7-4-6-17(31)14-19)26(20-8-2-3-9-21(20)30)27(39)34-18-15-29(32,33)16-18/h2-11,14,18,22,26H,12-13,15-16H2,1H3,(H,34,39)	PWADGCFTVYFXKI-UHFFFAOYSA-N	363549	US9850277, Compound 41::US10689414, Compound 41::US10640534, Compound 41::US10717764, Compound 41::US11021515, Compound 41::US11667673, Compound 41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363549&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707856	401959002							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719811	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cscn1 |r|	InChI=1S/C26H22ClF3N4O3S/c27-19-7-2-1-6-18(19)23(24(36)32-16-11-26(29,30)12-16)33(17-5-3-4-15(28)10-17)25(37)20-8-9-22(35)34(20)21-13-38-14-31-21/h1-7,10,13-14,16,20,23H,8-9,11-12H2,(H,32,36)	BVSZFZYUBWWULE-UHFFFAOYSA-N	363550	US9850277, Compound 42::US10689414, Compound 42::US10640534, Compound 42::US10717764, Compound 42::US11021515, Compound 42::US11667673, Compound 42	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>3000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363550&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699849	401959003							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719813	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cscn1 |r|	InChI=1S/C26H22ClF3N4O3S/c27-19-7-2-1-6-18(19)23(24(36)32-16-11-26(29,30)12-16)33(17-5-3-4-15(28)10-17)25(37)20-8-9-22(35)34(20)21-13-38-14-31-21/h1-7,10,13-14,16,20,23H,8-9,11-12H2,(H,32,36)	BVSZFZYUBWWULE-UHFFFAOYSA-N	363551	US9850277, Compound 43::US10689414, Compound 43::US10640534, Compound 43::US10717764, Compound 43::US11021515, Compound 43::US11667673, Compound 43	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363551&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699734	401959004							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719815	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1Cc1ccccn1 |r|	InChI=1S/C29H26ClF3N4O3/c30-23-10-2-1-9-22(23)26(27(39)35-20-15-29(32,33)16-20)37(21-8-5-6-18(31)14-21)28(40)24-11-12-25(38)36(24)17-19-7-3-4-13-34-19/h1-10,13-14,20,24,26H,11-12,15-17H2,(H,35,39)	DQVODDVYWWAOQC-UHFFFAOYSA-N	363552	US9850277, Compound 44::US10689414, Compound 44::US10640534, Compound 44::US10717764, Compound 44::US11021515, Compound 44::US11667673, Compound 44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363552&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699953	401959005							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719817	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1COCC(=O)N1c1ncccn1 |r|	InChI=1S/C27H23ClF3N5O4/c28-20-8-2-1-7-19(20)23(24(38)34-17-12-27(30,31)13-17)35(18-6-3-5-16(29)11-18)25(39)21-14-40-15-22(37)36(21)26-32-9-4-10-33-26/h1-11,17,21,23H,12-15H2,(H,34,38)	WHTZBGLMWBVRDT-UHFFFAOYSA-N	363553	US9850277, Compound 45::US10689414, Compound 45::US10640534, Compound 45::US10717764, Compound 45::US11021515, Compound 45::US11667673, Compound 45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363553&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86690600	401959006							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719819	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ccc(cn1)C#N |r|	InChI=1S/C29H23ClF3N5O3/c30-22-7-2-1-6-21(22)26(27(40)36-19-13-29(32,33)14-19)37(20-5-3-4-18(31)12-20)28(41)23-9-11-25(39)38(23)24-10-8-17(15-34)16-35-24/h1-8,10,12,16,19,23,26H,9,11,13-14H2,(H,36,40)	COACOKWKMBXXGC-UHFFFAOYSA-N	363555	US9850277, Compound 46::US10689414, Compound 46::US10640534, Compound 46::US10717764, Compound 46::US11021515, Compound 46::US11667673, Compound 46	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363555&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707859	401959008							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719821	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ccc(cn1)C#N |r|	InChI=1S/C29H23ClF3N5O3/c30-22-7-2-1-6-21(22)26(27(40)36-19-13-29(32,33)14-19)37(20-5-3-4-18(31)12-20)28(41)23-9-11-25(39)38(23)24-10-8-17(15-34)16-35-24/h1-8,10,12,16,19,23,26H,9,11,13-14H2,(H,36,40)	COACOKWKMBXXGC-UHFFFAOYSA-N	363556	US9850277, Compound 47::US10689414, Compound 47::US10640534, Compound 47::US10717764, Compound 47::US11021515, Compound 47::US11667673, Compound 47	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363556&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707860	401959009							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719823	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ccc(Cl)cn1 |r|	InChI=1S/C28H23Cl2F3N4O3/c29-16-8-10-23(34-15-16)37-22(9-11-24(37)38)27(40)36(19-5-3-4-17(31)12-19)25(20-6-1-2-7-21(20)30)26(39)35-18-13-28(32,33)14-18/h1-8,10,12,15,18,22,25H,9,11,13-14H2,(H,35,39)	IGKPNPLXJJOZHS-UHFFFAOYSA-N	363557	US9850277, Compound 48::US10689414, Compound 48::US10640534, Compound 48::US10717764, Compound 48::US11021515, Compound 48::US11667673, Compound 48	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363557&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707862	401959010							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719825	FC1CC(C1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1ncccn1)c1cccc(F)c1)c1ccccc1Cl |r,wU:8.9,wD:12.12,(-7.54,2.24,;-6.21,1.47,;-4.72,1.87,;-4.32,.38,;-5.81,-.01,;-2.99,-.38,;-1.65,.38,;-1.65,1.93,;-.32,-.38,;1.01,.38,;2.35,-.38,;2.35,-1.93,;3.68,.38,;3.68,1.93,;5.15,2.4,;6.05,1.15,;7.54,.76,;5.15,-.09,;5.55,-1.58,;4.46,-2.67,;4.86,-4.15,;6.34,-4.55,;7.43,-3.46,;7.03,-1.98,;1.01,1.93,;-.32,2.69,;-.32,4.23,;1.01,5,;2.35,4.23,;3.68,5,;2.35,2.69,;-.32,-1.93,;1.01,-2.69,;1.01,-4.23,;-.32,-5,;-1.65,-4.23,;-1.65,-2.69,;-3.19,-2.69,)|	InChI=1S/C27H24ClF2N5O3/c28-21-8-2-1-7-20(21)24(25(37)33-18-13-17(30)14-18)34(19-6-3-5-16(29)15-19)26(38)22-9-10-23(36)35(22)27-31-11-4-12-32-27/h1-8,11-12,15,17-18,22,24H,9-10,13-14H2,(H,33,37)	IBTFPSAOWVAVLH-UHFFFAOYSA-N	363558	US9850277, Compound 49::US10689414, Compound 49::US10640534, Compound 49::US10717764, Compound 49::US11021515, Compound 49::US11667673, Compound 49	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363558&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707861	401959011							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719827	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cccnn1 |r|	InChI=1S/C29H27ClF3N5O3/c30-22-8-2-1-7-21(22)26(27(40)35-19-12-14-29(32,33)15-13-19)37(20-6-3-5-18(31)17-20)28(41)23-10-11-25(39)38(23)24-9-4-16-34-36-24/h1-9,16-17,19,23,26H,10-15H2,(H,35,40)	PZQIJIWUOPSNLV-UHFFFAOYSA-N	363559	US9850277, Compound 50::US10689414, Compound 50::US10640534, Compound 50::US10717764, Compound 50::US11021515, Compound 50::US11667673, Compound 50	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363559&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707863	401959012							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719829	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1c(Cl)cccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncccn1 |r|	InChI=1S/C27H22Cl2F3N5O3/c28-18-6-2-7-19(29)22(18)23(24(39)35-16-13-27(31,32)14-16)36(17-5-1-4-15(30)12-17)25(40)20-8-9-21(38)37(20)26-33-10-3-11-34-26/h1-7,10-12,16,20,23H,8-9,13-14H2,(H,35,39)	KGIDCLBKTUVDTP-UHFFFAOYSA-N	363560	US9850277, Compound 51::US10689414, Compound 51::US10640534, Compound 51::US10717764, Compound 51::US11021515, Compound 51::US11667673, Compound 51	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363560&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707864	401959013							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719831	Fc1cccc(c1)N([C@@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C31H27ClF3N5O3/c32-24-7-2-1-6-23(24)28(29(42)38-21-10-13-31(34,35)14-11-21)39(22-5-3-4-20(33)17-22)30(43)25-8-9-27(41)40(25)26-16-19(18-36)12-15-37-26/h1-7,12,15-17,21,25,28H,8-11,13-14H2,(H,38,42)	JLCXBOXRVPRHLC-UHFFFAOYSA-N	363561	US9850277, Compound 52::US10689414, Compound 52::US10640534, Compound 52::US10717764, Compound 52::US11021515, Compound 52::US11667673, Compound 52	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363561&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707865	401959014							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719833	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C31H27ClF3N5O3/c32-24-7-2-1-6-23(24)28(29(42)38-21-10-13-31(34,35)14-11-21)39(22-5-3-4-20(33)17-22)30(43)25-8-9-27(41)40(25)26-16-19(18-36)12-15-37-26/h1-7,12,15-17,21,25,28H,8-11,13-14H2,(H,38,42)	JLCXBOXRVPRHLC-UHFFFAOYSA-N	363563	US9850277, Compound 53::US10689414, Compound 53::US10640534, Compound 53::US10717764, Compound 53::US11021515, Compound 53::US11667673, Compound 53	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363563&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657134	401959016							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719835	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H25ClF3N5O3/c31-23-8-2-1-7-22(23)27(28(41)37-20-15-30(33,34)16-20)38(21-6-3-5-19(32)14-21)29(42)24-9-4-10-26(40)39(24)25-13-18(17-35)11-12-36-25/h1-3,5-8,11-14,20,24,27H,4,9-10,15-16H2,(H,37,41)	HVUAKFIZNPTSGN-UHFFFAOYSA-N	363564	US9850277, Compound 54::US10689414, Compound 54::US10717764, Compound 54::US11021515, Compound 54	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363564&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89708749	401959017							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719837	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H25ClF3N5O3/c31-23-8-2-1-7-22(23)27(28(41)37-20-15-30(33,34)16-20)38(21-6-3-5-19(32)14-21)29(42)24-9-4-10-26(40)39(24)25-13-18(17-35)11-12-36-25/h1-3,5-8,11-14,20,24,27H,4,9-10,15-16H2,(H,37,41)	HVUAKFIZNPTSGN-UHFFFAOYSA-N	363565	US9850277, Compound 55::US10689414, Compound 55::US10640534, Compound 55::US10717764, Compound 55::US11021515, Compound 55	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363565&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699580	401959018							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719839	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncccc1F |r|	InChI=1S/C30H27ClF4N4O3/c31-22-8-2-1-7-21(22)26(28(41)37-19-12-14-30(34,35)15-13-19)38(20-6-3-5-18(32)17-20)29(42)24-10-11-25(40)39(24)27-23(33)9-4-16-36-27/h1-9,16-17,19,24,26H,10-15H2,(H,37,41)	WYMSLDXYSGVDTN-UHFFFAOYSA-N	363566	US9850277, Compound 56::US10689414, Compound 56::US10640534, Compound 56::US10717764, Compound 56::US11021515, Compound 56::US11667673, Compound 56	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363566&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707866	401959019							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719841	Fc1cccc(c1)N([C@@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cnccn1 |r|	InChI=1S/C29H27ClF3N5O3/c30-22-7-2-1-6-21(22)26(27(40)36-19-10-12-29(32,33)13-11-19)37(20-5-3-4-18(31)16-20)28(41)23-8-9-25(39)38(23)24-17-34-14-15-35-24/h1-7,14-17,19,23,26H,8-13H2,(H,36,40)	LZIRTPPXKUUODZ-UHFFFAOYSA-N	363567	US9850277, Compound 57::US10689414, Compound 57::US10640534, Compound 57::US10717764, Compound 57::US11021515, Compound 57::US11667673, Compound 57	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>3000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363567&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707867	401959020							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719843	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cnccn1 |r|	InChI=1S/C29H27ClF3N5O3/c30-22-7-2-1-6-21(22)26(27(40)36-19-10-12-29(32,33)13-11-19)37(20-5-3-4-18(31)16-20)28(41)23-8-9-25(39)38(23)24-17-34-14-15-35-24/h1-7,14-17,19,23,26H,8-13H2,(H,36,40)	LZIRTPPXKUUODZ-UHFFFAOYSA-N	363568	US9850277, Compound 58::US10689414, Compound 58::US10640534, Compound 58::US10717764, Compound 58::US11021515, Compound 58::US11667673, Compound 58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363568&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89700095	401959021							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719845	Nc1cccc(n1)N1[C@@H](CCC1=O)C(=O)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C28H25ClF3N5O3/c29-20-8-2-1-7-19(20)25(26(39)34-17-14-28(31,32)15-17)36(18-6-3-5-16(30)13-18)27(40)21-11-12-24(38)37(21)23-10-4-9-22(33)35-23/h1-10,13,17,21,25H,11-12,14-15H2,(H2,33,35)(H,34,39)	LILZITSTXWZWOD-UHFFFAOYSA-N	363569	US9850277, Compound 59::US10689414, Compound 59::US10640534, Compound 59::US10717764, Compound 59::US11021515, Compound 59::US11667673, Compound 59	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>3000							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363569&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707868	401959022							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719847	Nc1cccc(n1)N1[C@@H](CCC1=O)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C28H25ClF3N5O3/c29-20-8-2-1-7-19(20)25(26(39)34-17-14-28(31,32)15-17)36(18-6-3-5-16(30)13-18)27(40)21-11-12-24(38)37(21)23-10-4-9-22(33)35-23/h1-10,13,17,21,25H,11-12,14-15H2,(H2,33,35)(H,34,39)	LILZITSTXWZWOD-UHFFFAOYSA-N	363571	US9850277, Compound 60::US10689414, Compound 60::US10640534, Compound 60::US10717764, Compound 60::US11021515, Compound 60::US11667673, Compound 60	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363571&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707869	401959024							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719849	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cncs1 |r|	InChI=1S/C26H22ClF3N4O3S/c27-19-7-2-1-6-18(19)23(24(36)32-16-11-26(29,30)12-16)33(17-5-3-4-15(28)10-17)25(37)20-8-9-21(35)34(20)22-13-31-14-38-22/h1-7,10,13-14,16,20,23H,8-9,11-12H2,(H,32,36)	YQYGQGYNCDVXME-UHFFFAOYSA-N	363572	US9850277, Compound 61::US10689414, Compound 61::US10640534, Compound 61::US10717764, Compound 61::US11021515, Compound 61::US11667673, Compound 61	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363572&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707870	401959025							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719851	Nc1ccnc(c1)N1[C@@H](CCC1=O)C(=O)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C28H25ClF3N5O3/c29-21-7-2-1-6-20(21)25(26(39)35-18-14-28(31,32)15-18)36(19-5-3-4-16(30)12-19)27(40)22-8-9-24(38)37(22)23-13-17(33)10-11-34-23/h1-7,10-13,18,22,25H,8-9,14-15H2,(H2,33,34)(H,35,39)	AYAJVGUBUPODPY-UHFFFAOYSA-N	363573	US9850277, Compound 62::US10689414, Compound 62::US10640534, Compound 62::US10717764, Compound 62::US11667673, Compound 62	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1750							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363573&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707871	401959026							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719853	Fc1cccc(c1)N([C@@H](C(=O)NC1CC(F)(F)C1)c1c(Cl)cccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H22Cl2F3N5O3/c30-20-5-2-6-21(31)25(20)26(27(41)37-18-13-29(33,34)14-18)38(19-4-1-3-17(32)12-19)28(42)22-7-8-24(40)39(22)23-11-16(15-35)9-10-36-23/h1-6,9-12,18,22,26H,7-8,13-14H2,(H,37,41)	VBWGIZOBLNWNSL-UHFFFAOYSA-N	363574	US9850277, Compound 63::US10689414, Compound 63::US10640534, Compound 63::US10717764, Compound 63::US11021515, Compound 63::US11667673, Compound 63	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363574&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89708773	401959027							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719855	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H23ClF3N5O3/c30-22-7-2-1-6-21(22)26(27(40)36-19-14-29(32,33)15-19)37(20-5-3-4-18(31)13-20)28(41)23-8-9-25(39)38(23)24-12-17(16-34)10-11-35-24/h1-7,10-13,19,23,26H,8-9,14-15H2,(H,36,40)	LVTAMMPAQQMIPZ-UHFFFAOYSA-N	363545	US9850277, Compound 37::US9850277, Compound 64::US10689414, Compound 64::US10640534, Compound 64::US10717764, Compound 64::US11021515, Compound 64::US11667673, Compound 64	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363545&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89700075	401958998							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719857	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C28H22ClF3N6O3/c29-21-7-2-1-6-20(21)24(25(40)35-18-13-28(31,32)14-18)37(19-5-3-4-16(30)12-19)26(41)22-8-9-23(39)38(22)27-34-11-10-17(15-33)36-27/h1-7,10-12,18,22,24H,8-9,13-14H2,(H,35,40)	WCSZYVFQFJRLEV-UHFFFAOYSA-N	363576	US9850277, Compound 68::US10689414, Compound 68::US10640534, Compound 68::US10717764, Compound 68::US11021515, Compound 68::US11667673, Compound 68	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363576&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89700010	401959028							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719859	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncccc1C#N |r|	InChI=1S/C29H23ClF3N5O3/c30-22-9-2-1-8-21(22)25(27(40)36-19-14-29(32,33)15-19)37(20-7-3-6-18(31)13-20)28(41)23-10-11-24(39)38(23)26-17(16-34)5-4-12-35-26/h1-9,12-13,19,23,25H,10-11,14-15H2,(H,36,40)	HOXIQRRXXBEOBO-UHFFFAOYSA-N	363577	US9850277, Compound 69::US10689414, Compound 69::US10640534, Compound 69::US10717764, Compound 69::US11021515, Compound 69::US11667673, Compound 69	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363577&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699743	401959029							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719861	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncccn1 |r|	InChI=1S/C27H22ClF4N5O3/c28-20-5-2-1-4-19(20)23(24(39)35-17-13-27(31,32)14-17)36(18-11-15(29)10-16(30)12-18)25(40)21-6-7-22(38)37(21)26-33-8-3-9-34-26/h1-5,8-12,17,21,23H,6-7,13-14H2,(H,35,39)	BUVIOXMCRDPGRC-UHFFFAOYSA-N	363578	US9850277, Compound 70::US10689414, Compound 70::US10640534, Compound 70::US10717764, Compound 70::US11021515, Compound 70::US11667673, Compound 70	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363578&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699866	401959030							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719863	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H22ClF4N5O3/c30-22-4-2-1-3-21(22)26(27(41)37-19-13-29(33,34)14-19)38(20-11-17(31)10-18(32)12-20)28(42)23-5-6-25(40)39(23)24-9-16(15-35)7-8-36-24/h1-4,7-12,19,23,26H,5-6,13-14H2,(H,37,41)	KICQCOSIQLKQBA-UHFFFAOYSA-N	363579	US9850277, Compound 71::US9850277, Compound 163::US10689414, Compound 163::US10640534, Compound 163::US10717764, Compound 163::US11021515, Compound 163::US11667673, Compound 163	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363579&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699884	401959031							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719865	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1cscn1 |r|	InChI=1S/C25H20ClF3N4O4S/c26-18-7-2-1-6-17(18)21(22(34)31-15-9-25(28,29)10-15)32(16-5-3-4-14(27)8-16)23(35)19-11-37-24(36)33(19)20-12-38-13-30-20/h1-8,12-13,15,19,21H,9-11H2,(H,31,34)	VIOYFAYJHYKQQA-UHFFFAOYSA-N	363580	US9850277, Compound 72::US10689414, Compound 72::US10640534, Compound 72::US10717764, Compound 72::US11021515, Compound 72::US11667673, Compound 72	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363580&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89700209	401959032							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719867	Fc1cccc(c1)N([C@H](C(=O)N[C@H]1CCC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncccn1 |r|	InChI=1S/C28H25ClF3N5O3/c29-21-8-2-1-7-20(21)24(25(39)35-18-11-12-28(31,32)16-18)36(19-6-3-5-17(30)15-19)26(40)22-9-10-23(38)37(22)27-33-13-4-14-34-27/h1-8,13-15,18,22,24H,9-12,16H2,(H,35,39)	ZLYUNZVZRUVFAX-UHFFFAOYSA-N	363581	US9850277, Compound 73::US10689414, Compound 73::US10717764, Compound 73::US11021515, Compound 73::US11667673, Compound 73	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363581&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89711355	401959033							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719869	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cscn1 |r|	InChI=1S/C28H26ClF3N4O3S/c29-21-7-2-1-6-20(21)25(26(38)34-18-10-12-28(31,32)13-11-18)35(19-5-3-4-17(30)14-19)27(39)22-8-9-24(37)36(22)23-15-40-16-33-23/h1-7,14-16,18,22,25H,8-13H2,(H,34,38)	NNLLCCIBLADXHQ-UHFFFAOYSA-N	363582	US9850277, Compound 74::US10689414, Compound 74::US10640534, Compound 74::US10717764, Compound 74::US11021515, Compound 74::US11667673, Compound 74	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363582&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707874	401959034							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719871	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C32H29ClF3N5O3/c33-25-8-2-1-7-24(25)29(30(43)39-22-11-14-32(35,36)15-12-22)40(23-6-3-5-21(34)18-23)31(44)26-9-4-10-28(42)41(26)27-17-20(19-37)13-16-38-27/h1-3,5-8,13,16-18,22,26,29H,4,9-12,14-15H2,(H,39,43)	PYJCQKGRYZJDGK-UHFFFAOYSA-N	363583	US9850277, Compound 75::US10689414, Compound 75::US10640534, Compound 75::US10717764, Compound 75::US11021515, Compound 75::US11667673, Compound 75	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363583&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699545	401959035							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719873	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1ncccn1 |r|	InChI=1S/C28H25ClF3N5O4/c29-21-8-2-1-7-20(21)23(24(38)35-18-9-11-28(31,32)12-10-18)36(19-6-3-5-17(30)15-19)25(39)22-16-41-27(40)37(22)26-33-13-4-14-34-26/h1-8,13-15,18,22-23H,9-12,16H2,(H,35,38)	CRGXKSLJFWSBMI-UHFFFAOYSA-N	363584	US9850277, Compound 76::US10689414, Compound 78::US10640534, Compound 76::US10717764, Compound 76::US11021515, Compound 76::US11667673, Compound 76	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363584	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363584&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699725	401959036							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719875	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C28H21ClF3N5O4/c29-21-7-2-1-6-20(21)24(25(38)35-18-12-28(31,32)13-18)36(19-5-3-4-17(30)11-19)26(39)22-15-41-27(40)37(22)23-10-16(14-33)8-9-34-23/h1-11,18,22,24H,12-13,15H2,(H,35,38)	HTRBLQKFOCUZKD-UHFFFAOYSA-N	363585	US9850277, Compound 77::US10689414, Compound 77::US10640534, Compound 77::US10717764, Compound 77::US11021515, Compound 77::US11667673, Compound 77	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363585&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699781	401959037							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719877	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H25ClF3N5O4/c31-23-7-2-1-6-22(23)26(27(40)37-20-8-11-30(33,34)12-9-20)38(21-5-3-4-19(32)15-21)28(41)24-17-43-29(42)39(24)25-14-18(16-35)10-13-36-25/h1-7,10,13-15,20,24,26H,8-9,11-12,17H2,(H,37,40)	XCPHAKYOINLUBX-UHFFFAOYSA-N	363586	US9850277, Compound 78::US10640534, Compound 78::US10717764, Compound 78::US11021515, Compound 78::US11667673, Compound 78	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363586&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699471	401959038							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719879	CN1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H24ClF3N6O3/c1-37-16-23(39(28(37)42)24-11-17(15-34)9-10-35-24)27(41)38(20-6-4-5-18(31)12-20)25(21-7-2-3-8-22(21)30)26(40)36-19-13-29(32,33)14-19/h2-12,19,23,25H,13-14,16H2,1H3,(H,36,40)	AHQAKBHZGHUNQX-UHFFFAOYSA-N	363587	US9850277, Compound 79::US10689414, Compound 79::US10640534, Compound 79::US10717764, Compound 79::US11021515, Compound 79	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363587	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363587&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89700007	401959039							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719881	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CNC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C28H22ClF3N6O3/c29-21-7-2-1-6-20(21)24(25(39)36-18-12-28(31,32)13-18)37(19-5-3-4-17(30)11-19)26(40)22-15-35-27(41)38(22)23-10-16(14-33)8-9-34-23/h1-11,18,22,24H,12-13,15H2,(H,35,41)(H,36,39)	MELMGGWIAVKJQO-UHFFFAOYSA-N	363588	US9850277, Compound 80::US10689414, Compound 80::US10640534, Compound 80::US10717764, Compound 80::US11021515, Compound 80::US11667673, Compound 80	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363588	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363588&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699600	401959040							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719883	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C31H26ClF4N5O3/c32-24-4-2-1-3-23(24)28(29(43)39-21-7-10-31(35,36)11-8-21)40(22-15-19(33)14-20(34)16-22)30(44)25-5-6-27(42)41(25)26-13-18(17-37)9-12-38-26/h1-4,9,12-16,21,25,28H,5-8,10-11H2,(H,39,43)	SPJCWFFCGIYMTC-UHFFFAOYSA-N	363589	US9850277, Compound 81::US10689414, Compound 81::US10640534, Compound 81::US10717764, Compound 81::US11021515, Compound 81::US11667673, Compound 81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363589&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707878	401959041							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719885	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(C#N)c1F |r|	InChI=1S/C29H22ClF4N5O3/c30-21-7-2-1-6-20(21)25(27(41)37-18-13-29(33,34)14-18)38(19-5-3-4-17(31)12-19)28(42)22-8-9-23(40)39(22)26-24(32)16(15-35)10-11-36-26/h1-7,10-12,18,22,25H,8-9,13-14H2,(H,37,41)	MRCPGLJHHAYGDB-UHFFFAOYSA-N	363590	US9850277, Compound 82::US10689414, Compound 82::US10640534, Compound 82::US10717764, Compound 82::US11021515, Compound 82::US11667673, Compound 82	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363590	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363590&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699682	401959042							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719887	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(C#N)c1F |r|	InChI=1S/C31H26ClF4N5O3/c32-23-7-2-1-6-22(23)27(29(43)39-20-10-13-31(35,36)14-11-20)40(21-5-3-4-19(33)16-21)30(44)24-8-9-25(42)41(24)28-26(34)18(17-37)12-15-38-28/h1-7,12,15-16,20,24,27H,8-11,13-14H2,(H,39,43)	RLMQRNHTTAAEPT-UHFFFAOYSA-N	363591	US9850277, Compound 83::US10689414, Compound 83::US10640534, Compound 83::US10717764, Compound 83::US11021515, Compound 83::US11667673, Compound 83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363591&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89700121	401959043							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719889	NS(=O)(=O)c1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H25ClF2N6O5S/c30-22-7-2-1-6-21(22)26(27(40)36-18-14-29(31,32)15-18)37(19-4-3-5-20(13-19)44(34,42)43)28(41)23-8-9-25(39)38(23)24-12-17(16-33)10-11-35-24/h1-7,10-13,18,23,26H,8-9,14-15H2,(H,36,40)(H2,34,42,43)	IXGSJIHNRYNQIX-UHFFFAOYSA-N	363592	US9850277, Compound 84::US10689414, Compound 84::US10640534, Compound 84::US10717764, Compound 84::US11021515, Compound 84::US11667673, Compound 84	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363592&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699559	401959044							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719891	Fc1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C30H26ClF3N6O3/c31-23-7-2-1-6-22(23)26(27(42)37-19-10-13-30(33,34)14-11-19)39(21-5-3-4-18(32)16-21)28(43)24-8-9-25(41)40(24)29-36-15-12-20(17-35)38-29/h1-7,12,15-16,19,24,26H,8-11,13-14H2,(H,37,42)	VNFCBYHEBLFKDJ-UHFFFAOYSA-N	363594	US9850277, Compound 85::US10689414, Compound 85::US10640534, Compound 85::US10717764, Compound 85::US11021515, Compound 85::US11667673, Compound 85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363594&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699473	401959046							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719893	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C28H21ClF4N6O3/c29-21-4-2-1-3-20(21)24(25(41)36-18-12-28(32,33)13-18)38(19-10-15(30)9-16(31)11-19)26(42)22-5-6-23(40)39(22)27-35-8-7-17(14-34)37-27/h1-4,7-11,18,22,24H,5-6,12-13H2,(H,36,41)	BHXJMLXDEUJSGK-UHFFFAOYSA-N	363595	US9850277, Compound 86::US10689414, Compound 86::US10640534, Compound 86::US10717764, Compound 86::US11021515, Compound 86::US11667673, Compound 86	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363595&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699777	401959047							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719895	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C30H25ClF4N6O3/c31-23-4-2-1-3-22(23)26(27(43)38-19-7-10-30(34,35)11-8-19)40(21-14-17(32)13-18(33)15-21)28(44)24-5-6-25(42)41(24)29-37-12-9-20(16-36)39-29/h1-4,9,12-15,19,24,26H,5-8,10-11H2,(H,38,43)	FACIRSQMPRSNGP-UHFFFAOYSA-N	363596	US9850277, Compound 87::US10689414, Compound 87::US10640534, Compound 87::US10717764, Compound 87::US11021515, Compound 87::US11667673, Compound 87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363596&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699528	401959048							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719897	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(C#N)c1F |r|	InChI=1S/C29H21ClF5N5O3/c30-21-4-2-1-3-20(21)25(27(42)38-18-12-29(34,35)13-18)39(19-10-16(31)9-17(32)11-19)28(43)22-5-6-23(41)40(22)26-24(33)15(14-36)7-8-37-26/h1-4,7-11,18,22,25H,5-6,12-13H2,(H,38,42)	FSFQFBBIBVXCAK-UHFFFAOYSA-N	363597	US9850277, Compound 88::US10689414, Compound 88::US10640534, Compound 88::US10717764, Compound 88::US11021515, Compound 88::US11667673, Compound 88	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363597&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699992	401959049							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719899	CC(C)(C)OC(=O)N1C[C@H](N(C(=O)C1)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C34H32ClF3N6O5/c1-33(2,3)49-32(48)42-18-26(44(28(45)19-42)27-13-20(17-39)11-12-40-27)31(47)43(23-8-6-7-21(36)14-23)29(24-9-4-5-10-25(24)35)30(46)41-22-15-34(37,38)16-22/h4-14,22,26,29H,15-16,18-19H2,1-3H3,(H,41,46)	BANLQGVIUZDTJG-UHFFFAOYSA-N	363598	US9850277, Compound 89::US10689414, Compound 89::US10640534, Compound 89::US10717764, Compound 89::US11021515, Compound 89::US11667673, Compound 89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363598&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707966	401959050							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719901	Fc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCOC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H23ClF3N5O4/c30-22-7-2-1-6-21(22)25(26(39)36-19-14-29(32,33)15-19)37(20-5-3-4-18(31)13-20)27(40)23-9-11-42-28(41)38(23)24-12-17(16-34)8-10-35-24/h1-8,10,12-13,19,23,25H,9,11,14-15H2,(H,36,39)	WRKXERBFBRLAEJ-UHFFFAOYSA-N	363599	US9850277, Compound 90::US10640534, Compound 90::US10717764, Compound 90::US11667673, Compound 90	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363599&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89700094	401959051							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719903	Fc1cncc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)	WIJZXSAJMHAVGX-UHFFFAOYSA-N	363600	US9850277, Compound 91::US10689414, Compound 91::US10640534, Compound 91::US10717764, Compound 91::US11667673, Compound 91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363600&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699486	401959052							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719905	CC(=O)N1C[C@H](N(C(=O)C1)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C31H26ClF3N6O4/c1-18(42)39-16-25(41(27(43)17-39)26-11-19(15-36)9-10-37-26)30(45)40(22-6-4-5-20(33)12-22)28(23-7-2-3-8-24(23)32)29(44)38-21-13-31(34,35)14-21/h2-12,21,25,28H,13-14,16-17H2,1H3,(H,38,44)	OUQWDHLTDLNHJN-UHFFFAOYSA-N	363601	US9850277, Compound 92::US10689414, Compound 92::US10640534, Compound 92::US10717764, Compound 92::US11021515, Compound 92::US11667673, Compound 92	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363601&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86690606	401959053							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719907	CC(C)(C)OC(=O)N1C[C@H](N(C(=O)C1)c1nccc(n1)C#N)C(=O)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C35H34ClF4N7O5/c1-34(2,3)52-33(51)45-18-27(47(28(48)19-45)32-42-13-10-23(17-41)44-32)31(50)46(24-15-20(37)14-21(38)16-24)29(25-6-4-5-7-26(25)36)30(49)43-22-8-11-35(39,40)12-9-22/h4-7,10,13-16,22,27,29H,8-9,11-12,18-19H2,1-3H3,(H,43,49)	OOKMYLRSAKAGGR-UHFFFAOYSA-N	363602	US9850277, Compound 93::US10689414, Compound 93::US10640534, Compound 93::US10717764, Compound 93::US11021515, Compound 93::US11667673, Compound 93	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363602&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707887	401959054							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719909	CCOC(=O)CN1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C32H28ClF3N6O5/c1-2-47-27(43)18-40-17-25(42(31(40)46)26-12-19(16-37)10-11-38-26)30(45)41(22-7-5-6-20(34)13-22)28(23-8-3-4-9-24(23)33)29(44)39-21-14-32(35,36)15-21/h3-13,21,25,28H,2,14-15,17-18H2,1H3,(H,39,44)	XKUYMOBPJINALI-UHFFFAOYSA-N	363605	US9850277, Compound 94::US10689414, Compound 94::US10640534, Compound 94::US10717764, Compound 94::US11667673, Compound 94	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363605&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86690633	401959056							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719911	CS(=O)(=O)c1cccc(c1)N(C(C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C32H30ClF2N5O5S/c1-46(44,45)23-6-4-5-22(18-23)39(31(43)26-9-10-28(41)40(26)27-17-20(19-36)13-16-37-27)29(24-7-2-3-8-25(24)33)30(42)38-21-11-14-32(34,35)15-12-21/h2-8,13,16-18,21,26,29H,9-12,14-15H2,1H3,(H,38,42)	DALSLUXHMCXKOX-UHFFFAOYSA-N	363606	US9850277, Compound 95::US10689414, Compound 95::US10640534, Compound 95::US10717764, Compound 95::US11021515, Compound 95::US11667673, Compound 95	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363606&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699723	401959057							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719913	CS(=O)(=O)c1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H26ClF2N5O5S/c1-44(42,43)21-6-4-5-20(14-21)37(29(41)24-9-10-26(39)38(24)25-13-18(17-34)11-12-35-25)27(22-7-2-3-8-23(22)31)28(40)36-19-15-30(32,33)16-19/h2-8,11-14,19,24,27H,9-10,15-16H2,1H3,(H,36,40)	WKNABTPTCYOUFK-UHFFFAOYSA-N	363607	US9850277, Compound 96::US10689414, Compound 96::US10640534, Compound 96::US10717764, Compound 96::US11021515, Compound 96::US11667673, Compound 96	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363607&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699944	401959058							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719915	CC(C)(C)OC(=O)N1C[C@H](N(C(=O)C1)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C34H31ClF4N6O5/c1-33(2,3)50-32(49)43-17-26(45(28(46)18-43)27-10-19(16-40)8-9-41-27)31(48)44(23-12-20(36)11-21(37)13-23)29(24-6-4-5-7-25(24)35)30(47)42-22-14-34(38,39)15-22/h4-13,22,26,29H,14-15,17-18H2,1-3H3,(H,42,47)	NBBOZZYCTJIARB-UHFFFAOYSA-N	363608	US9850277, Compound 97::US10689414, Compound 97::US10640534, Compound 97::US10717764, Compound 97::US11021515, Compound 97	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363608&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707967	401959059							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719917	CC(C)(C)OC(=O)N1C[C@H](N(C(=O)C1)c1nccc(n1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C33H30ClF4N7O5/c1-32(2,3)50-31(49)43-16-25(45(26(46)17-43)30-40-9-8-20(15-39)42-30)29(48)44(22-11-18(35)10-19(36)12-22)27(23-6-4-5-7-24(23)34)28(47)41-21-13-33(37,38)14-21/h4-12,21,25,27H,13-14,16-17H2,1-3H3,(H,41,47)	IUNCTNMRVWJOSU-UHFFFAOYSA-N	363609	US9850277, Compound 98::US10689414, Compound 98::US10640534, Compound 98::US10717764, Compound 98::US11021515, Compound 98::US11667673, Compound 98	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363609&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707965	401959060							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719919	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CNCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C28H22ClF4N7O3/c29-21-4-2-1-3-20(21)24(25(42)37-18-10-28(32,33)11-18)39(19-8-15(30)7-16(31)9-19)26(43)22-13-35-14-23(41)40(22)27-36-6-5-17(12-34)38-27/h1-9,18,22,24,35H,10-11,13-14H2,(H,37,42)	XXXSWJFXEYXJFL-UHFFFAOYSA-N	363610	US9850277, Compound 99::US10689414, Compound 99::US10640534, Compound 99::US10717764, Compound 99::US11021515, Compound 99::US11667673, Compound 99	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363610&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657247	401959061							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719921	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CNCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H23ClF4N6O3/c30-22-4-2-1-3-21(22)26(27(42)38-19-11-29(33,34)12-19)39(20-9-17(31)8-18(32)10-20)28(43)23-14-36-15-25(41)40(23)24-7-16(13-35)5-6-37-24/h1-10,19,23,26,36H,11-12,14-15H2,(H,38,42)	LQBYWGAJHMTLHT-UHFFFAOYSA-N	363611	US9850277, Compound 100::US10689414, Compound 100::US10640534, Compound 100::US10717764, Compound 100::US11021515, Compound 100::US11667673, Compound 100	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363611	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363611&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657353	401959062							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719923	CN1C[C@H](N(C(=O)C1)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C30H25ClF4N6O3/c1-39-15-24(41(26(42)16-39)25-8-17(14-36)6-7-37-25)29(44)40(21-10-18(32)9-19(33)11-21)27(22-4-2-3-5-23(22)31)28(43)38-20-12-30(34,35)13-20/h2-11,20,24,27H,12-13,15-16H2,1H3,(H,38,43)	QJEBLQACNOGKQO-UHFFFAOYSA-N	363612	US9850277, Compound 101::US10689414, Compound 101::US10640534, Compound 101::US10717764, Compound 101::US11021515, Compound 101::US11667673, Compound 101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363612&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657354	401959063							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719925	CS(=O)(=O)c1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C29H25ClF2N6O5S/c1-44(42,43)20-6-4-5-19(13-20)37(27(41)23-9-10-24(39)38(23)28-34-12-11-17(16-33)36-28)25(21-7-2-3-8-22(21)30)26(40)35-18-14-29(31,32)15-18/h2-8,11-13,18,23,25H,9-10,14-15H2,1H3,(H,35,40)	BHVLUTCWSVLIGI-UHFFFAOYSA-N	363613	US9850277, Compound 102::US10689414, Compound 102::US10640534, Compound 102::US10717764, Compound 102::US11021515, Compound 102::US11667673, Compound 102	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363613&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657355	401959064							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719927	CS(=O)(=O)c1cccc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C31H29ClF2N6O5S/c1-46(44,45)22-6-4-5-21(17-22)39(29(43)25-9-10-26(41)40(25)30-36-16-13-20(18-35)38-30)27(23-7-2-3-8-24(23)32)28(42)37-19-11-14-31(33,34)15-12-19/h2-8,13,16-17,19,25,27H,9-12,14-15H2,1H3,(H,37,42)	CHSBBVUPZCWOII-UHFFFAOYSA-N	363614	US9850277, Compound 103::US10689414, Compound 103::US10640534, Compound 103::US10717764, Compound 103::US11021515, Compound 103::US11667673, Compound 103	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363614&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657565	401959065							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719929	CCOC(=O)CN1C[C@H](N(C(=O)C1)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C33H29ClF4N6O5/c1-2-49-29(46)18-42-16-26(44(28(45)17-42)27-9-19(15-39)7-8-40-27)32(48)43(23-11-20(35)10-21(36)12-23)30(24-5-3-4-6-25(24)34)31(47)41-22-13-33(37,38)14-22/h3-12,22,26,30H,2,13-14,16-18H2,1H3,(H,41,47)	DMAIXYDWQGBGSF-UHFFFAOYSA-N	363615	US9850277, Compound 104::US10689414, Compound 104::US10640534, Compound 104::US10717764, Compound 104::US11021515, Compound 104::US11667673, Compound 104	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363615&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707969	401959066							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719931	CS(=O)(=O)c1cc(F)cc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C32H29ClF3N5O5S/c1-47(45,46)23-16-20(34)15-22(17-23)40(31(44)26-6-7-28(42)41(26)27-14-19(18-37)10-13-38-27)29(24-4-2-3-5-25(24)33)30(43)39-21-8-11-32(35,36)12-9-21/h2-5,10,13-17,21,26,29H,6-9,11-12H2,1H3,(H,39,43)	AQXHTRJAGRYZRT-UHFFFAOYSA-N	363616	US9850277, Compound 105::US11021515, Compound 105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363616&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657678	401959067							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719933	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CN(CC(=O)N1c1cc(ccn1)C#N)C1CC1 |r|	InChI=1S/C32H27ClF4N6O3/c33-25-4-2-1-3-24(25)29(30(45)40-21-13-32(36,37)14-21)42(23-11-19(34)10-20(35)12-23)31(46)26-16-41(22-5-6-22)17-28(44)43(26)27-9-18(15-38)7-8-39-27/h1-4,7-12,21-22,26,29H,5-6,13-14,16-17H2,(H,40,45)	WZJIOHMGOOFJQE-UHFFFAOYSA-N	363617	US9850277, Compound 106::US10689414, Compound 106::US10640534, Compound 106::US10717764, Compound 106::US11021515, Compound 106::US11667673, Compound 106	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363617&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86690608	401959068							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719935	OCCN1C[C@H](N(C(=O)C1)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C31H27ClF4N6O4/c32-24-4-2-1-3-23(24)28(29(45)39-21-13-31(35,36)14-21)41(22-11-19(33)10-20(34)12-22)30(46)25-16-40(7-8-43)17-27(44)42(25)26-9-18(15-37)5-6-38-26/h1-6,9-12,21,25,28,43H,7-8,13-14,16-17H2,(H,39,45)	ZCMHCAKOIRNDDK-UHFFFAOYSA-N	363618	US9850277, Compound 107::US10689414, Compound 107::US10640534, Compound 107::US10717764, Compound 107::US11021515, Compound 107::US11667673, Compound 107	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363618&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89705456	401959069							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719937	CS(=O)(=O)c1cc(F)cc(c1)N(C(C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C31H28ClF3N6O5S/c1-47(45,46)22-15-18(33)14-21(16-22)40(29(44)25-6-7-26(42)41(25)30-37-13-10-20(17-36)39-30)27(23-4-2-3-5-24(23)32)28(43)38-19-8-11-31(34,35)12-9-19/h2-5,10,13-16,19,25,27H,6-9,11-12H2,1H3,(H,38,43)	RQQJQPCYZQWNLO-UHFFFAOYSA-N	363619	US9850277, Compound 108::US10689414, Compound 108::US10640534, Compound 108::US10717764, Compound 108::US11667673, Compound 108	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363619&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699677	401959070							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719939	CS(=O)(=O)c1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C29H24ClF3N6O5S/c1-45(43,44)20-11-16(31)10-19(12-20)38(27(42)23-6-7-24(40)39(23)28-35-9-8-17(15-34)37-28)25(21-4-2-3-5-22(21)30)26(41)36-18-13-29(32,33)14-18/h2-5,8-12,18,23,25H,6-7,13-14H2,1H3,(H,36,41)	QSKCJDJWUNSQEQ-UHFFFAOYSA-N	363620	US9850277, Compound 109::US10640534, Compound 109::US10717764, Compound 109::US11021515, Compound 109::US11667673, Compound 109	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363620&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657139	401959071							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719941	CS(=O)(=O)c1cc(F)cc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H25ClF3N5O5S/c1-45(43,44)21-12-18(32)11-20(13-21)38(29(42)24-6-7-26(40)39(24)25-10-17(16-35)8-9-36-25)27(22-4-2-3-5-23(22)31)28(41)37-19-14-30(33,34)15-19/h2-5,8-13,19,24,27H,6-7,14-15H2,1H3,(H,37,41)	SCCPCYNFZXXVLQ-UHFFFAOYSA-N	363621	US9850277, Compound 110::US10717764, Compound 110::US11667673, Compound 110	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363621&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699741	401959072							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719943	CCOC(=O)CN1C[C@H](N(C1=O)c1nccc(n1)C#N)C(=O)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C31H27ClF3N7O5/c1-2-47-25(43)17-40-16-24(42(30(40)46)29-37-11-10-19(15-36)39-29)28(45)41(21-7-5-6-18(33)12-21)26(22-8-3-4-9-23(22)32)27(44)38-20-13-31(34,35)14-20/h3-12,20,24,26H,2,13-14,16-17H2,1H3,(H,38,44)	KOFDSMNVMVYQLB-UHFFFAOYSA-N	363622	US9850277, Compound 111::US10689414, Compound 111::US10640534, Compound 111::US10717764, Compound 111::US11021515, Compound 111::US11667673, Compound 111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363622&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699500	401959073							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719945	OCCN1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C30H26ClF3N6O4/c31-23-7-2-1-6-22(23)26(27(42)37-20-14-30(33,34)15-20)39(21-5-3-4-19(32)13-21)28(43)24-17-38(10-11-41)29(44)40(24)25-12-18(16-35)8-9-36-25/h1-9,12-13,20,24,26,41H,10-11,14-15,17H2,(H,37,42)	VUOSCTWKQJJYNF-UHFFFAOYSA-N	363623	US9850277, Compound 112::US10689414, Compound 112::US10640534, Compound 112::US10717764, Compound 112::US11021515, Compound 112::US11667673, Compound 112	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363623&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699484	401959074							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719947	O[C@@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H23ClF3N5O4/c30-21-7-2-1-6-20(21)25(26(40)36-18-13-29(32,33)14-18)37(19-5-3-4-17(31)11-19)27(41)22-12-23(39)28(42)38(22)24-10-16(15-34)8-9-35-24/h1-11,18,22-23,25,39H,12-14H2,(H,36,40)	HITFKTSXSYNXEY-UHFFFAOYSA-N	363624	US9850277, Compound 113::US10689414, Compound 113::US10640534, Compound 113::US10717764, Compound 113::US11021515, Compound 113::US11667673, Compound 113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363624&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657245	401959075							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719949	O[C@@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C29H22ClF4N5O4/c30-21-4-2-1-3-20(21)25(26(41)37-18-12-29(33,34)13-18)38(19-9-16(31)8-17(32)10-19)27(42)22-11-23(40)28(43)39(22)24-7-15(14-35)5-6-36-24/h1-10,18,22-23,25,40H,11-13H2,(H,37,41)	CEYKEKGDKNZKJE-UHFFFAOYSA-N	363625	US9850277, Compound 114::US10689414, Compound 114::US10640534, Compound 114::US10717764, Compound 114::US11021515, Compound 114::US11667673, Compound 114	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363625&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657246	401959076							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719951	O[C@@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C29H22ClF4N5O4/c30-21-4-2-1-3-20(21)25(26(41)37-18-12-29(33,34)13-18)38(19-9-16(31)8-17(32)10-19)27(42)22-11-23(40)28(43)39(22)24-7-15(14-35)5-6-36-24/h1-10,18,22-23,25,40H,11-13H2,(H,37,41)	CEYKEKGDKNZKJE-UHFFFAOYSA-N	363626	US9850277, Compound 115::US10689414, Compound 115::US10640534, Compound 115::US10717764, Compound 115::US11021515, Compound 115::US11667673, Compound 115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363626&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656858	401959077							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719953	O[C@@H]1C[C@H](N(C1=O)c1nccc(n1)C#N)C(=O)N([C@@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C28H21ClF4N6O4/c29-20-4-2-1-3-19(20)23(24(41)36-17-11-28(32,33)12-17)38(18-8-14(30)7-15(31)9-18)25(42)21-10-22(40)26(43)39(21)27-35-6-5-16(13-34)37-27/h1-9,17,21-23,40H,10-12H2,(H,36,41)	GYKVHPWYXLIJFP-UHFFFAOYSA-N	363627	US9850277, Compound 116::US10689414, Compound 116::US10640534, Compound 116::US10717764, Compound 116::US11021515, Compound 116::US11667673, Compound 116	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363627&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656951	401959078							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719955	O[C@@H]1C[C@H](N(C1=O)c1nccc(n1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C28H21ClF4N6O4/c29-20-4-2-1-3-19(20)23(24(41)36-17-11-28(32,33)12-17)38(18-8-14(30)7-15(31)9-18)25(42)21-10-22(40)26(43)39(21)27-35-6-5-16(13-34)37-27/h1-9,17,21-23,40H,10-12H2,(H,36,41)	GYKVHPWYXLIJFP-UHFFFAOYSA-N	363628	US9850277, Compound 117::US10689414, Compound 117::US10640534, Compound 117::US10717764, Compound 117::US11021515, Compound 117::US11667673, Compound 117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363628&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656952	401959079							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719957	O[C@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C29H23ClF3N5O4/c30-21-7-2-1-6-20(21)25(26(40)36-18-13-29(32,33)14-18)37(19-5-3-4-17(31)11-19)27(41)22-12-23(39)28(42)38(22)24-10-16(15-34)8-9-35-24/h1-11,18,22-23,25,39H,12-14H2,(H,36,40)	HITFKTSXSYNXEY-UHFFFAOYSA-N	363630	US9850277, Compound 118::US10689414, Compound 118::US10640534, Compound 118::US10717764, Compound 118::US11021515, Compound 118::US11667673, Compound 118	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363630&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656953	401959081							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719959	O[C@H]1C[C@H](N(C1=O)c1nccc(n1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C28H22ClF3N6O4/c29-20-7-2-1-6-19(20)23(24(40)35-17-12-28(31,32)13-17)37(18-5-3-4-15(30)10-18)25(41)21-11-22(39)26(42)38(21)27-34-9-8-16(14-33)36-27/h1-10,17,21-23,39H,11-13H2,(H,35,40)	GLKNGSWMTABBHU-UHFFFAOYSA-N	363631	US9850277, Compound 119::US10689414, Compound 119::US10640534, Compound 119::US10717764, Compound 119::US11021515, Compound 119::US11667673, Compound 119	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363631&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657137	401959082							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719961	O[C@@H]1C[C@H](N(C1=O)c1nccc(n1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C28H22ClF3N6O4/c29-20-7-2-1-6-19(20)23(24(40)35-17-12-28(31,32)13-17)37(18-5-3-4-15(30)10-18)25(41)21-11-22(39)26(42)38(21)27-34-9-8-16(14-33)36-27/h1-10,17,21-23,39H,11-13H2,(H,35,40)	GLKNGSWMTABBHU-UHFFFAOYSA-N	363632	US9850277, Compound 120::US10640534, Compound 120::US10717764, Compound 120::US11021515, Compound 120::US11667673, Compound 120	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363632&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657043	401959083							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719963	O[C@@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C31H27ClF3N5O4/c32-23-7-2-1-6-22(23)27(28(42)38-20-8-11-31(34,35)12-9-20)39(21-5-3-4-19(33)15-21)29(43)24-16-25(41)30(44)40(24)26-14-18(17-36)10-13-37-26/h1-7,10,13-15,20,24-25,27,41H,8-9,11-12,16H2,(H,38,42)	ZMWJRAJUGBQNSR-UHFFFAOYSA-N	363633	US9850277, Compound 121::US10689414, Compound 121::US10640534, Compound 121::US10717764, Compound 121::US11021515, Compound 121::US11667673, Compound 121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363633&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657044	401959084							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719965	O[C@@H]1C[C@H](N(C1=O)c1nccc(n1)C#N)C(=O)N([C@@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C30H26ClF3N6O4/c31-22-7-2-1-6-21(22)25(26(42)37-18-8-11-30(33,34)12-9-18)39(20-5-3-4-17(32)14-20)27(43)23-15-24(41)28(44)40(23)29-36-13-10-19(16-35)38-29/h1-7,10,13-14,18,23-25,41H,8-9,11-12,15H2,(H,37,42)	LHIJKVKSIGTZTB-UHFFFAOYSA-N	363634	US9850277, Compound 122::US10689414, Compound 122::US10640534, Compound 122::US10717764, Compound 122::US11021515, Compound 122::US11667673, Compound 122	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363634&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657045	401959085							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719967	O[C@@H]1C[C@H](N(C1=O)c1nccc(n1)C#N)C(=O)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C30H26ClF3N6O4/c31-22-7-2-1-6-21(22)25(26(42)37-18-8-11-30(33,34)12-9-18)39(20-5-3-4-17(32)14-20)27(43)23-15-24(41)28(44)40(23)29-36-13-10-19(16-35)38-29/h1-7,10,13-14,18,23-25,41H,8-9,11-12,15H2,(H,37,42)	LHIJKVKSIGTZTB-UHFFFAOYSA-N	363635	US9850277, Compound 123::US10689414, Compound 123::US10640534, Compound 123::US10717764, Compound 123::US11021515, Compound 123::US11667673, Compound 123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363635&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656765	401959086							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719969	O[C@@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C31H26ClF4N5O4/c32-23-4-2-1-3-22(23)27(28(43)39-20-5-8-31(35,36)9-6-20)40(21-13-18(33)12-19(34)14-21)29(44)24-15-25(42)30(45)41(24)26-11-17(16-37)7-10-38-26/h1-4,7,10-14,20,24-25,27,42H,5-6,8-9,15H2,(H,39,43)	IMOFWCACDGLXAQ-UHFFFAOYSA-N	363637	US9850277, Compound 124::US10689414, Compound 124::US10640534, Compound 124::US10717764, Compound 124::US11021515, Compound 124::US11667673, Compound 124	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363637&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699901	401959088							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719971	O[C@@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C31H26ClF4N5O4/c32-23-4-2-1-3-22(23)27(28(43)39-20-5-8-31(35,36)9-6-20)40(21-13-18(33)12-19(34)14-21)29(44)24-15-25(42)30(45)41(24)26-11-17(16-37)7-10-38-26/h1-4,7,10-14,20,24-25,27,42H,5-6,8-9,15H2,(H,39,43)	IMOFWCACDGLXAQ-UHFFFAOYSA-N	363638	US9850277, Compound 125::US10689414, Compound 125::US10640534, Compound 125::US10717764, Compound 125::US11021515, Compound 125::US11667673, Compound 125	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363638&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656767	401959089							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719973	O[C@@H]1C[C@H](N(C1=O)c1nccc(n1)C#N)C(=O)N([C@@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C30H25ClF4N6O4/c31-22-4-2-1-3-21(22)25(26(43)38-18-5-8-30(34,35)9-6-18)40(20-12-16(32)11-17(33)13-20)27(44)23-14-24(42)28(45)41(23)29-37-10-7-19(15-36)39-29/h1-4,7,10-13,18,23-25,42H,5-6,8-9,14H2,(H,38,43)	UEZUXIBTQPCFJK-UHFFFAOYSA-N	363639	US9850277, Compound 126::US10689414, Compound 126::US10640534, Compound 126::US10717764, Compound 126::US11021515, Compound 126::US11667673, Compound 126	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363639&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656766	401959090							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719975	O[C@@H]1C[C@H](N(C1=O)c1nccc(n1)C#N)C(=O)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C30H25ClF4N6O4/c31-22-4-2-1-3-21(22)25(26(43)38-18-5-8-30(34,35)9-6-18)40(20-12-16(32)11-17(33)13-20)27(44)23-14-24(42)28(45)41(23)29-37-10-7-19(15-36)39-29/h1-4,7,10-13,18,23-25,42H,5-6,8-9,14H2,(H,38,43)	UEZUXIBTQPCFJK-UHFFFAOYSA-N	363640	US9850277, Compound 127::US10689414, Compound 127::US10640534, Compound 127::US10717764, Compound 127::US11021515, Compound 127::US11667673, Compound 127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363640&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656950	401959091							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719977	FC1(F)CC(C1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cccc(c1)C#N)c1ccccc1Cl |r|	InChI=1S/C30H23ClF2N6O3/c31-23-7-2-1-6-22(23)27(28(41)37-20-14-30(32,33)15-20)38(21-5-3-4-18(12-21)16-34)29(42)24-8-9-26(40)39(24)25-13-19(17-35)10-11-36-25/h1-7,10-13,20,24,27H,8-9,14-15H2,(H,37,41)	MOZQKVSZMSFZFY-UHFFFAOYSA-N	363641	US9850277, Compound 128::US10689414, Compound 128::US10640534, Compound 128::US10717764, Compound 128::US11021515, Compound 128::US11667673, Compound 128	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363641&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656855	401959092							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719979	COc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H26ClF2N5O4/c1-42-21-6-4-5-20(14-21)37(29(41)24-9-10-26(39)38(24)25-13-18(17-34)11-12-35-25)27(22-7-2-3-8-23(22)31)28(40)36-19-15-30(32,33)16-19/h2-8,11-14,19,24,27H,9-10,15-16H2,1H3,(H,36,40)	LVKKYPKVAKECNR-UHFFFAOYSA-N	363642	US9850277, Compound 129::US10689414, Compound 129::US10640534, Compound 129::US10717764, Compound 129::US11021515, Compound 129::US11667673, Compound 129	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363642&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656856	401959093							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719981	OCCOc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C31H28ClF2N5O5/c32-24-7-2-1-6-23(24)28(29(42)37-20-16-31(33,34)17-20)38(21-4-3-5-22(15-21)44-13-12-40)30(43)25-8-9-27(41)39(25)26-14-19(18-35)10-11-36-26/h1-7,10-11,14-15,20,25,28,40H,8-9,12-13,16-17H2,(H,37,42)	LIPHIEXIZBAWHI-UHFFFAOYSA-N	363643	US9850277, Compound 130::US10689414, Compound 130::US10640534, Compound 130::US10717764, Compound 130::US11021515, Compound 130::US11667673, Compound 130	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363643&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656857	401959094							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719983	OCc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H26ClF2N5O4/c31-23-7-2-1-6-22(23)27(28(41)36-20-14-30(32,33)15-20)37(21-5-3-4-19(12-21)17-39)29(42)24-8-9-26(40)38(24)25-13-18(16-34)10-11-35-25/h1-7,10-13,20,24,27,39H,8-9,14-15,17H2,(H,36,41)	XLBMVGQAYDFMHL-UHFFFAOYSA-N	363644	US9850277, Compound 131::US10689414, Compound 131::US10640534, Compound 131::US10717764, Compound 131::US11021515, Compound 131::US11667673, Compound 131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363644&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699511	401959095							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719985	Fc1cncc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H24ClF3N6O4/c30-22-4-2-1-3-21(22)25(26(40)37-19-5-8-29(32,33)9-6-19)38(20-12-18(31)14-35-15-20)27(41)23-16-43-28(42)39(23)24-11-17(13-34)7-10-36-24/h1-4,7,10-12,14-15,19,23,25H,5-6,8-9,16H2,(H,37,40)	YQGRTCGDQCWOMA-UHFFFAOYSA-N	363645	US9850277, Compound 132::US10689414, Compound 132::US10640534, Compound 132::US10717764, Compound 132::US11021515, Compound 132::US11667673, Compound 132	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363645&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656584	401959096							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719987	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCOC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H22ClF4N5O4/c30-22-4-2-1-3-21(22)25(26(40)37-19-13-29(33,34)14-19)38(20-11-17(31)10-18(32)12-20)27(41)23-6-8-43-28(42)39(23)24-9-16(15-35)5-7-36-24/h1-5,7,9-12,19,23,25H,6,8,13-14H2,(H,37,40)	IVQTUCSKJSKDRA-UHFFFAOYSA-N	363646	US9850277, Compound 133::US10689414, Compound 133::US10640534, Compound 133::US10717764, Compound 133::US11021515, Compound 133::US11667673, Compound 133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363646&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656585	401959097							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719989	Fc1cc(cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1cc(ccn1)C#N)C#N |r|	InChI=1S/C29H20ClF3N6O4/c30-22-4-2-1-3-21(22)25(26(40)37-19-11-29(32,33)12-19)38(20-8-17(14-35)7-18(31)10-20)27(41)23-15-43-28(42)39(23)24-9-16(13-34)5-6-36-24/h1-10,19,23,25H,11-12,15H2,(H,37,40)	HDXKKWIPXADQOT-UHFFFAOYSA-N	363647	US9850277, Compound 134::US10689414, Compound 134::US10640534, Compound 134::US10717764, Compound 134::US11021515, Compound 134::US11667673, Compound 134	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363647&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656764	401959098							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719991	Fc1cncc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C27H20ClF3N6O4/c28-20-4-2-1-3-19(20)23(24(38)35-17-9-27(30,31)10-17)36(18-8-16(29)12-33-13-18)25(39)21-14-41-26(40)37(21)22-7-15(11-32)5-6-34-22/h1-8,12-13,17,21,23H,9-10,14H2,(H,35,38)	SCHVCLWDSRCNTE-UHFFFAOYSA-N	363648	US9850277, Compound 135::US10689414, Compound 135::US10640534, Compound 135::US10717764, Compound 135::US11021515, Compound 135::US11667673, Compound 135	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363648&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656676	401959099							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719993	Fc1cc(cc2cn[nH]c12)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C32H27ClF3N7O3/c33-23-4-2-1-3-22(23)29(30(45)40-20-7-10-32(35,36)11-8-20)42(21-14-19-17-39-41-28(19)24(34)15-21)31(46)25-5-6-27(44)43(25)26-13-18(16-37)9-12-38-26/h1-4,9,12-15,17,20,25,29H,5-8,10-11H2,(H,39,41)(H,40,45)	BBRDYZKSFLDBPC-UHFFFAOYSA-N	363649	US9850277, Compound 136::US10640534, Compound 136::US10717764, Compound 136::US11021515, Compound 136::US11667673, Compound 136	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363649&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656677	401959100							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719995	Fc1cncc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCOC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H26ClF3N6O4/c31-23-4-2-1-3-22(23)26(27(41)38-20-5-9-30(33,34)10-6-20)39(21-14-19(32)16-36-17-21)28(42)24-8-12-44-29(43)40(24)25-13-18(15-35)7-11-37-25/h1-4,7,11,13-14,16-17,20,24,26H,5-6,8-10,12H2,(H,38,41)	XTVGVCVRBJUKSW-UHFFFAOYSA-N	363650	US9850277, Compound 137::US10689414, Compound 137::US10640534, Compound 137::US10717764, Compound 137::US11021515, Compound 137::US11667673, Compound 137	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363650&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656678	401959101							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719997	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H24F3N5O3/c30-20-7-4-8-22(14-20)36(26(19-5-2-1-3-6-19)27(39)35-21-15-29(31,32)16-21)28(40)23-9-10-25(38)37(23)24-13-18(17-33)11-12-34-24/h1-8,11-14,21,23,26H,9-10,15-16H2,(H,35,39)	RLORRIOOVFASIB-UHFFFAOYSA-N	363651	US9850277, Compound 138::US10689414, Compound 138::US10640534, Compound 138::US10717764, Compound 138::US11021515, Compound 138::US11667673, Compound 138	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363651&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656679	401959102							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
719999	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCOC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C31H26ClF4N5O4/c32-24-4-2-1-3-23(24)27(28(42)39-21-5-9-31(35,36)10-6-21)40(22-15-19(33)14-20(34)16-22)29(43)25-8-12-45-30(44)41(25)26-13-18(17-37)7-11-38-26/h1-4,7,11,13-16,21,25,27H,5-6,8-10,12H2,(H,39,42)	MXUZEFGBLPRNCF-UHFFFAOYSA-N	363652	US9850277, Compound 139::US10689414, Compound 139::US10640534, Compound 139::US10717764, Compound 139::US11021515, Compound 139::US11667673, Compound 139	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363652&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656582	401959103							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720001	OC1(CC1)c1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C32H28ClF2N5O4/c33-24-7-2-1-6-23(24)28(29(42)38-21-16-32(34,35)17-21)39(22-5-3-4-20(15-22)31(44)11-12-31)30(43)25-8-9-27(41)40(25)26-14-19(18-36)10-13-37-26/h1-7,10,13-15,21,25,28,44H,8-9,11-12,16-17H2,(H,38,42)	MQUWSLVEIHMPEF-UHFFFAOYSA-N	363653	US9850277, Compound 140::US10640534, Compound 140::US10717764, Compound 140::US11021515, Compound 140::US11667673, Compound 140	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363653	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363653&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656374	401959104							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720003	FC1(F)CCC(CC1)NC(=O)C(N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cccc2[nH]cnc12)c1ccccc1Cl |r|	InChI=1S/C32H28ClF2N7O3/c33-22-5-2-1-4-21(22)29(30(44)40-20-10-13-32(34,35)14-11-20)42(24-7-3-6-23-28(24)39-18-38-23)31(45)25-8-9-27(43)41(25)26-16-19(17-36)12-15-37-26/h1-7,12,15-16,18,20,25,29H,8-11,13-14H2,(H,38,39)(H,40,44)	AOKUPZGWXWHPJH-UHFFFAOYSA-N	363654	US9850277, Compound 141::US10689414, Compound 141::US10640534, Compound 141::US10717764, Compound 141::US11021515, Compound 141::US11667673, Compound 141	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363654&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86690624	401959105							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720005	FC1(F)CCC(CC1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cccc2cn[nH]c12)c1ccccc1Cl |r|	InChI=1S/C32H28ClF2N7O3/c33-23-6-2-1-5-22(23)29(30(44)39-21-10-13-32(34,35)14-11-21)42(24-7-3-4-20-18-38-40-28(20)24)31(45)25-8-9-27(43)41(25)26-16-19(17-36)12-15-37-26/h1-7,12,15-16,18,21,25,29H,8-11,13-14H2,(H,38,40)(H,39,44)	XNWUIVIZPHKIDU-UHFFFAOYSA-N	363655	US9850277, Compound 142::US10689414, Compound 142::US10640534, Compound 142::US10717764, Compound 142::US11021515, Compound 142::US11667673, Compound 142	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363655	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363655&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145452958	401959106							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720007	Fc1cncc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCOC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C28H22ClF3N6O4/c29-21-4-2-1-3-20(21)24(25(39)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)26(40)22-6-8-42-27(41)38(22)23-9-16(13-33)5-7-35-23/h1-5,7,9-10,14-15,18,22,24H,6,8,11-12H2,(H,36,39)	OZPXDAJSVCYNNF-UHFFFAOYSA-N	363656	US9850277, Compound 143::US10689414, Compound 143::US10640534, Compound 143::US10717764, Compound 143::US11021515, Compound 143	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363656	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363656&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656375	401959107							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720009	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCOC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C30H25ClF4N6O4/c31-23-4-2-1-3-22(23)25(26(42)38-19-5-9-30(34,35)10-6-19)40(21-14-17(32)13-18(33)15-21)27(43)24-8-12-45-29(44)41(24)28-37-11-7-20(16-36)39-28/h1-4,7,11,13-15,19,24-25H,5-6,8-10,12H2,(H,38,42)	VQJHOXGWXBTTPK-UHFFFAOYSA-N	363657	US9850277, Compound 144::US10689414, Compound 144::US10640534, Compound 144::US10717764, Compound 144::US11021515, Compound 144::US11667673, Compound 144	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363657&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699564	401959108							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720011	CC(C)(O)c1cc(F)cc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C31H27ClF3N5O5/c1-30(2,44)18-10-19(33)12-21(11-18)39(28(42)24-16-45-29(43)40(24)25-9-17(15-36)7-8-37-25)26(22-5-3-4-6-23(22)32)27(41)38-20-13-31(34,35)14-20/h3-12,20,24,26,44H,13-14,16H2,1-2H3,(H,38,41)	TZXIEFFSQLYJQJ-UHFFFAOYSA-N	363658	US9850277, Compound 145::US10640534, Compound 145::US10717764, Compound 145::US11021515, Compound 145::US11667673, Compound 145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363658	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363658&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699619	401959109							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720013	CC(C)(O)c1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCOC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C32H29ClF3N5O5/c1-31(2,45)19-12-20(34)14-22(13-19)40(27(23-5-3-4-6-24(23)33)28(42)39-21-15-32(35,36)16-21)29(43)25-8-10-46-30(44)41(25)26-11-18(17-37)7-9-38-26/h3-7,9,11-14,21,25,27,45H,8,10,15-16H2,1-2H3,(H,39,42)	POIIFFFQSQIQHA-UHFFFAOYSA-N	363659	US9850277, Compound 146::US10689414, Compound 146::US10640534, Compound 146::US10717764, Compound 146::US11021515, Compound 146::US11667673, Compound 146	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363659&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656479	401959110							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720015	Fc1cncc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C28H23F3N6O3/c29-19-11-21(16-33-15-19)36(25(18-4-2-1-3-5-18)26(39)35-20-12-28(30,31)13-20)27(40)22-6-7-24(38)37(22)23-10-17(14-32)8-9-34-23/h1-5,8-11,15-16,20,22,25H,6-7,12-13H2,(H,35,39)	BKWVETAXXJILAU-UHFFFAOYSA-N	363660	US9850277, Compound 147::US10689414, Compound 147::US10640534, Compound 147::US10717764, Compound 147::US11021515, Compound 147::US11667673, Compound 147	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363660	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363660&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699526	401959111							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720017	Fc1cncc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1F)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C28H22F4N6O3/c29-17-10-19(15-34-14-17)37(27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23)25(20-3-1-2-4-21(20)30)26(40)36-18-11-28(31,32)12-18/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)	SUANQEARPHOGRR-UHFFFAOYSA-N	363661	US9850277, Compound 148::US10689414, Compound 148::US10640534, Compound 148::US10717764, Compound 148::US11021515, Compound 148::US11667673, Compound 148	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363661&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699518	401959112							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720019	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1F)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H23F4N5O3/c30-18-4-3-5-20(13-18)37(28(41)23-8-9-25(39)38(23)24-12-17(16-34)10-11-35-24)26(21-6-1-2-7-22(21)31)27(40)36-19-14-29(32,33)15-19/h1-7,10-13,19,23,26H,8-9,14-15H2,(H,36,40)	AGDOJAFSZKVDGU-UHFFFAOYSA-N	363662	US9850277, Compound 149::US10689414, Compound 149::US10640534, Compound 149::US10717764, Compound 149::US11021515, Compound 149::US11667673, Compound 149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363662	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363662&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656274	401959113							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720021	CC(C)(O)c1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#C |r|	InChI=1S/C33H30ClF3N4O4/c1-4-19-11-12-38-27(13-19)41-26(9-10-28(41)42)31(44)40(23-15-20(32(2,3)45)14-21(35)16-23)29(24-7-5-6-8-25(24)34)30(43)39-22-17-33(36,37)18-22/h1,5-8,11-16,22,26,29,45H,9-10,17-18H2,2-3H3,(H,39,43)	JDWMNYUNELKFRO-UHFFFAOYSA-N	363663	US9850277, Compound 150::US11667673, Compound 150	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363663	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363663&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124193798	401959114							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720023	F[C@@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C31H26ClF4N5O3/c32-23-7-2-1-6-22(23)27(28(42)39-20-8-11-31(35,36)12-9-20)40(21-5-3-4-19(33)15-21)30(44)25-16-24(34)29(43)41(25)26-14-18(17-37)10-13-38-26/h1-7,10,13-15,20,24-25,27H,8-9,11-12,16H2,(H,39,42)	JMDFVJCPOQZKCU-UHFFFAOYSA-N	363664	US9850277, Compound 151::US10689414, Compound 151::US10640534, Compound 151::US10717764, Compound 151::US11021515, Compound 151::US11667673, Compound 151	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363664	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363664&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656373	401959115							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720025	FC1(F)CC(C1)NC(=O)C(N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cccc2[nH]ncc12)c1ccccc1Cl |r|	InChI=1S/C30H24ClF2N7O3/c31-21-5-2-1-4-19(21)27(28(42)37-18-13-30(32,33)14-18)40(23-7-3-6-22-20(23)16-36-38-22)29(43)24-8-9-26(41)39(24)25-12-17(15-34)10-11-35-25/h1-7,10-12,16,18,24,27H,8-9,13-14H2,(H,36,38)(H,37,42)	MBVBELUTRVZREP-UHFFFAOYSA-N	363665	US9850277, Compound 152::US10689414, Compound 152::US10640534, Compound 152::US10717764, Compound 152::US11021515, Compound 152::US11667673, Compound 152	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363665	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363665&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145452959	401959116							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720027	FC1(F)CC(C1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cc(cc(c1)C#N)C#N)c1ccccc1Cl |r|	InChI=1S/C31H22ClF2N7O3/c32-24-4-2-1-3-23(24)28(29(43)39-21-13-31(33,34)14-21)40(22-10-19(16-36)9-20(11-22)17-37)30(44)25-5-6-27(42)41(25)26-12-18(15-35)7-8-38-26/h1-4,7-12,21,25,28H,5-6,13-14H2,(H,39,43)	JVZLOTLFFCFWBA-UHFFFAOYSA-N	363666	US9850277, Compound 153::US10689414, Compound 153::US10640534, Compound 153::US10717764, Compound 153::US11021515, Compound 153::US11667673, Compound 153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363666	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363666&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657133	401959117							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720029	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCOC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C28H21ClF4N6O4/c29-21-4-2-1-3-20(21)23(24(40)36-18-12-28(32,33)13-18)38(19-10-15(30)9-16(31)11-19)25(41)22-6-8-43-27(42)39(22)26-35-7-5-17(14-34)37-26/h1-5,7,9-11,18,22-23H,6,8,12-13H2,(H,36,40)	BEWMGBTVYNQDOG-UHFFFAOYSA-N	363667	US9850277, Compound 154::US10689414, Compound 154::US10640534, Compound 154::US10717764, Compound 154::US11021515, Compound 154::US11667673, Compound 154	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363667	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363667&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699642	401959118							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720031	CC(C)(O)c1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C32H30F3N5O4/c1-31(2,44)21-13-22(33)15-24(14-21)39(28(20-6-4-3-5-7-20)29(42)38-23-16-32(34,35)17-23)30(43)25-8-9-27(41)40(25)26-12-19(18-36)10-11-37-26/h3-7,10-15,23,25,28,44H,8-9,16-17H2,1-2H3,(H,38,42)	CWFLCBXOMIENMO-UHFFFAOYSA-N	363668	US9850277, Compound 155::US10689414, Compound 155::US10640534, Compound 155::US10717764, Compound 155::US11021515, Compound 155::US11667673, Compound 155	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363668	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363668&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707925	401959119							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720033	CN(C)S(=O)(=O)c1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C31H29ClF2N6O5S/c1-38(2)46(44,45)22-7-5-6-21(15-22)39(30(43)25-10-11-27(41)40(25)26-14-19(18-35)12-13-36-26)28(23-8-3-4-9-24(23)32)29(42)37-20-16-31(33,34)17-20/h3-9,12-15,20,25,28H,10-11,16-17H2,1-2H3,(H,37,42)	ZXVYIJWNIVZMJM-UHFFFAOYSA-N	363669	US9850277, Compound 156::US10689414, Compound 156::US10640534, Compound 156::US10717764, Compound 156::US11021515, Compound 156::US11667673, Compound 156	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363669	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363669&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657791	401959120							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720035	CNS(=O)(=O)c1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H27ClF2N6O5S/c1-35-45(43,44)21-6-4-5-20(14-21)38(29(42)24-9-10-26(40)39(24)25-13-18(17-34)11-12-36-25)27(22-7-2-3-8-23(22)31)28(41)37-19-15-30(32,33)16-19/h2-8,11-14,19,24,27,35H,9-10,15-16H2,1H3,(H,37,41)	VTJAXLZURITKHL-UHFFFAOYSA-N	363670	US9850277, Compound 157::US10689414, Compound 157::US10640534, Compound 157::US10717764, Compound 157::US11021515, Compound 157::US11667673, Compound 157	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363670	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363670&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657792	401959121							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720037	NS(=O)(=O)c1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H24ClF3N6O5S/c30-22-4-2-1-3-21(22)26(27(41)37-18-13-29(32,33)14-18)38(19-10-17(31)11-20(12-19)45(35,43)44)28(42)23-5-6-25(40)39(23)24-9-16(15-34)7-8-36-24/h1-4,7-12,18,23,26H,5-6,13-14H2,(H,37,41)(H2,35,43,44)	PFIJJYHIKFHICJ-UHFFFAOYSA-N	363671	US9850277, Compound 158::US10689414, Compound 158::US10640534, Compound 158::US10717764, Compound 158::US11021515, Compound 158::US11667673, Compound 158	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363671	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363671&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657793	401959122							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720039	CS(=O)(=O)Nc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H27ClF2N6O5S/c1-45(43,44)37-19-5-4-6-21(14-19)38(29(42)24-9-10-26(40)39(24)25-13-18(17-34)11-12-35-25)27(22-7-2-3-8-23(22)31)28(41)36-20-15-30(32,33)16-20/h2-8,11-14,20,24,27,37H,9-10,15-16H2,1H3,(H,36,41)	PDXIYNMEIVGTEM-UHFFFAOYSA-N	363672	US9850277, Compound 159::US10689414, Compound 159::US10640534, Compound 159::US10717764, Compound 159::US11021515, Compound 159::US11667673, Compound 159	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363672	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363672&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656372	401959123							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720041	OCCc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C31H28ClF2N5O4/c32-24-7-2-1-6-23(24)28(29(42)37-21-16-31(33,34)17-21)38(22-5-3-4-19(14-22)11-13-40)30(43)25-8-9-27(41)39(25)26-15-20(18-35)10-12-36-26/h1-7,10,12,14-15,21,25,28,40H,8-9,11,13,16-17H2,(H,37,42)	HNSJWOTXMJVNME-UHFFFAOYSA-N	363673	US9850277, Compound 160::US10689414, Compound 160::US10640534, Compound 160::US10717764, Compound 160::US11021515, Compound 160::US11667673, Compound 160	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363673	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363673&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656271	401959124							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720043	CN(C)c1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C31H29ClF2N6O3/c1-38(2)21-6-5-7-22(15-21)39(30(43)25-10-11-27(41)40(25)26-14-19(18-35)12-13-36-26)28(23-8-3-4-9-24(23)32)29(42)37-20-16-31(33,34)17-20/h3-9,12-15,20,25,28H,10-11,16-17H2,1-2H3,(H,37,42)	DZVPQUYLMIIRMO-UHFFFAOYSA-N	363674	US9850277, Compound 161::US10689414, Compound 161::US10640534, Compound 161::US10717764, Compound 161::US11021515, Compound 161::US11667673, Compound 161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363674	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363674&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656272	401959125							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720045	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1ncc(o1)C#N |r|	InChI=1S/C27H20ClF4N5O4/c28-20-4-2-1-3-19(20)23(24(39)35-16-10-27(31,32)11-16)36(17-8-14(29)7-15(30)9-17)25(40)21-5-6-22(38)37(21)26-34-13-18(12-33)41-26/h1-4,7-9,13,16,21,23H,5-6,10-11H2,(H,35,39)	DVWRXABLNUGTNX-UHFFFAOYSA-N	363675	US9850277, Compound 162::US10689414, Compound 162::US10640534, Compound 162::US10717764, Compound 162::US11021515, Compound 162::US11667673, Compound 162	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363675	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363675&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656273	401959126							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720047	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H22ClF4N5O3/c30-22-4-2-1-3-21(22)26(27(41)37-19-13-29(33,34)14-19)38(20-11-17(31)10-18(32)12-20)28(42)23-5-6-25(40)39(23)24-9-16(15-35)7-8-36-24/h1-4,7-12,19,23,26H,5-6,13-14H2,(H,37,41)	KICQCOSIQLKQBA-UHFFFAOYSA-N	363579	US9850277, Compound 71::US9850277, Compound 163::US10689414, Compound 163::US10640534, Compound 163::US10717764, Compound 163::US11021515, Compound 163::US11667673, Compound 163	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363579&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699884	401959031							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720049	COc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C29H25ClF2N6O4/c1-42-20-6-4-5-19(13-20)37(27(41)23-9-10-24(39)38(23)28-34-12-11-17(16-33)36-28)25(21-7-2-3-8-22(21)30)26(40)35-18-14-29(31,32)15-18/h2-8,11-13,18,23,25H,9-10,14-15H2,1H3,(H,35,40)	RTTFSFYIVVXTLC-UHFFFAOYSA-N	363677	US9850277, Compound 164::US10689414, Compound 164::US10640534, Compound 164::US10717764, Compound 164::US11021515, Compound 164::US11667673, Compound 164	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363677	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363677&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657562	401959127							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720050	CC(C)(C)c1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C32H31ClF2N6O3/c1-31(2,3)19-7-6-8-22(15-19)40(29(44)25-11-12-26(42)41(25)30-37-14-13-20(18-36)39-30)27(23-9-4-5-10-24(23)33)28(43)38-21-16-32(34,35)17-21/h4-10,13-15,21,25,27H,11-12,16-17H2,1-3H3,(H,38,43)	VLVWCMFEWIITFQ-UHFFFAOYSA-N	363678	US9850277, Compound 165::US10689414, Compound 165::US10640534, Compound 165::US10717764, Compound 165::US11021515, Compound 165::US11667673, Compound 165	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363678	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363678&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657563	401959128							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720052	FC1(F)CCC(CC1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cccc(c1)C#N)c1ccccc1Cl |r|	InChI=1S/C32H27ClF2N6O3/c33-25-7-2-1-6-24(25)29(30(43)39-22-10-13-32(34,35)14-11-22)40(23-5-3-4-20(16-23)18-36)31(44)26-8-9-28(42)41(26)27-17-21(19-37)12-15-38-27/h1-7,12,15-17,22,26,29H,8-11,13-14H2,(H,39,43)	NWTJGIZNJQWQNT-UHFFFAOYSA-N	363679	US9850277, Compound 166::US10689414, Compound 166::US10640534, Compound 166::US10717764, Compound 166::US11021515, Compound 166::US11667673, Compound 166	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363679	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363679&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657564	401959129							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720053	FC1(F)CC(C1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N)c1cccc(c1)C#N)c1ccccc1Cl |r|	InChI=1S/C29H22ClF2N7O3/c30-22-7-2-1-6-21(22)25(26(41)36-19-13-29(31,32)14-19)38(20-5-3-4-17(12-20)15-33)27(42)23-8-9-24(40)39(23)28-35-11-10-18(16-34)37-28/h1-7,10-12,19,23,25H,8-9,13-14H2,(H,36,41)	QHTMVLYGBIEEHT-UHFFFAOYSA-N	363680	US9850277, Compound 167::US10689414, Compound 167::US10640534, Compound 167::US10717764, Compound 167::US11021515, Compound 167::US11667673, Compound 167	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363680	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363680&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657677	401959130							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720055	CS(=O)(=O)c1cc(F)cc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C31H28ClF3N6O5S/c1-47(45,46)22-15-18(33)14-21(16-22)40(29(44)25-6-7-26(42)41(25)30-37-13-10-20(17-36)39-30)27(23-4-2-3-5-24(23)32)28(43)38-19-8-11-31(34,35)12-9-19/h2-5,10,13-16,19,25,27H,6-9,11-12H2,1H3,(H,38,43)	RQQJQPCYZQWNLO-UHFFFAOYSA-N	363681	US9850277, Compound 168::US10689414, Compound 168::US10640534, Compound 168::US10717764, Compound 168::US11021515, Compound 168::US11667673, Compound 168	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363681	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363681&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657138	401959131							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720056	O[C@@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(c1)C#N |r|	InChI=1S/C30H22ClF3N6O4/c31-22-4-2-1-3-21(22)26(27(42)38-19-12-30(33,34)13-19)39(20-8-17(15-36)7-18(32)10-20)28(43)23-11-24(41)29(44)40(23)25-9-16(14-35)5-6-37-25/h1-10,19,23-24,26,41H,11-13H2,(H,38,42)	FKXYCQZORNWWRU-UHFFFAOYSA-N	363682	US9850277, Compound 169::US10640534, Compound 169::US10717764, Compound 169::US11021515, Compound 169::US11667673, Compound 169	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363682	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363682&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699930	401959132							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720057	O[C@@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(c1)C#N |r|	InChI=1S/C30H23ClF2N6O4/c31-22-7-2-1-6-21(22)26(27(41)37-19-13-30(32,33)14-19)38(20-5-3-4-17(10-20)15-34)28(42)23-12-24(40)29(43)39(23)25-11-18(16-35)8-9-36-25/h1-11,19,23-24,26,40H,12-14H2,(H,37,41)	SNTMOFZKXROXSU-UHFFFAOYSA-N	363683	US9850277, Compound 170::US10689414, Compound 170::US10640534, Compound 170::US10717764, Compound 170::US11021515, Compound 170::US11667673, Compound 170	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363683&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86690612	401959133							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720058	O[C@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C29H22ClF4N5O4/c30-21-4-2-1-3-20(21)25(26(41)37-18-12-29(33,34)13-18)38(19-9-16(31)8-17(32)10-19)27(42)22-11-23(40)28(43)39(22)24-7-15(14-35)5-6-36-24/h1-10,18,22-23,25,40H,11-13H2,(H,37,41)	CEYKEKGDKNZKJE-UHFFFAOYSA-N	363684	US9850277, Compound 171::US10689414, Compound 171::US10640534, Compound 171::US10717764, Compound 171::US11021515, Compound 171::US11667673, Compound 171	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363684	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363684&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657350	401959134							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720059	O[C@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C31H27ClF3N5O4/c32-23-7-2-1-6-22(23)27(28(42)38-20-8-11-31(34,35)12-9-20)39(21-5-3-4-19(33)15-21)29(43)24-16-25(41)30(44)40(24)26-14-18(17-36)10-13-37-26/h1-7,10,13-15,20,24-25,27,41H,8-9,11-12,16H2,(H,38,42)	ZMWJRAJUGBQNSR-UHFFFAOYSA-N	363685	US9850277, Compound 172::US10689414, Compound 172::US10640534, Compound 172::US10717764, Compound 172::US11021515, Compound 172::US11667673, Compound 172	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363685	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363685&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657041	401959135							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720060	FC1(F)CC(C1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cccc(c1)C1CC1)c1ccccc1Cl |r|	InChI=1S/C32H28ClF2N5O3/c33-25-7-2-1-6-24(25)29(30(42)38-22-16-32(34,35)17-22)39(23-5-3-4-21(15-23)20-8-9-20)31(43)26-10-11-28(41)40(26)27-14-19(18-36)12-13-37-27/h1-7,12-15,20,22,26,29H,8-11,16-17H2,(H,38,42)	UCULEFMVYNZQAV-UHFFFAOYSA-N	363686	US9850277, Compound 173::US10689414, Compound 173::US10640534, Compound 173::US10717764, Compound 173::US11021515, Compound 173::US11667673, Compound 173	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363686	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363686&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657351	401959136							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720062	O[C@H]1C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cc(F)cc(F)c1 |r|	InChI=1S/C31H26ClF4N5O4/c32-23-4-2-1-3-22(23)27(28(43)39-20-5-8-31(35,36)9-6-20)40(21-13-18(33)12-19(34)14-21)29(44)24-15-25(42)30(45)41(24)26-11-17(16-37)7-10-38-26/h1-4,7,10-14,20,24-25,27,42H,5-6,8-9,15H2,(H,39,43)	IMOFWCACDGLXAQ-UHFFFAOYSA-N	363687	US9850277, Compound 174::US10689414, Compound 174::US10640534, Compound 174::US10717764, Compound 174::US11021515, Compound 174::US11667673, Compound 174	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363687	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363687&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657452	401959137							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720064	FC1(F)CC(C1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1ccc2[nH]ncc2c1)c1ccccc1Cl |r|	InChI=1S/C30H24ClF2N7O3/c31-22-4-2-1-3-21(22)27(28(42)37-19-13-30(32,33)14-19)39(20-5-6-23-18(12-20)16-36-38-23)29(43)24-7-8-26(41)40(24)25-11-17(15-34)9-10-35-25/h1-6,9-12,16,19,24,27H,7-8,13-14H2,(H,36,38)(H,37,42)	MMGNTQLURSXJMR-UHFFFAOYSA-N	363688	US9850277, Compound 175::US10689414, Compound 175::US10640534, Compound 175::US10717764, Compound 175::US11021515, Compound 175::US11667673, Compound 175	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363688	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363688&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657453	401959138							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720066	c1ccc(c(c1)[C@@H](C(=O)NC2CC(C2)(F)F)N(c3cc(cnc3)F)C(=O)[C@@H]4CCC(=O)N4c5cc(ccn5)C#N)Cl	InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)	WIJZXSAJMHAVGX-UHFFFAOYSA-N	363689	US9850277, Compound 176::US10682352, Compound AG120::US10640534, Compound 176::US10717764, Compound 176::US11021515, Compound 176::US11376246, Cpd ID AG-120::US11576906, Compound AG-120::US11311527, Cpd ID AG-120::US11667673, Compound 176	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363689	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363689&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	IV3	8T7O	71657455	401959139							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720068	Fc1cc(cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)C#N |r|	InChI=1S/C30H22ClF3N6O3/c31-23-4-2-1-3-22(23)27(28(42)38-20-13-30(33,34)14-20)39(21-10-18(16-36)9-19(32)12-21)29(43)24-5-6-26(41)40(24)25-11-17(15-35)7-8-37-25/h1-4,7-12,20,24,27H,5-6,13-14H2,(H,38,42)	OUOPAIJHGSDRMV-UHFFFAOYSA-N	363690	US9850277, Compound 177::US10689414, Compound 177::US10640534, Compound 177::US10717764, Compound 177::US11021515, Compound 177::US11667673, Compound 177	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363690	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363690&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657454	401959140							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720070	FC1(F)CCC(CC1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N)c1cccc(c1)C#N)c1ccccc1Cl |r|	InChI=1S/C31H26ClF2N7O3/c32-24-7-2-1-6-23(24)27(28(43)38-20-10-13-31(33,34)14-11-20)40(22-5-3-4-19(16-22)17-35)29(44)25-8-9-26(42)41(25)30-37-15-12-21(18-36)39-30/h1-7,12,15-16,20,25,27H,8-11,13-14H2,(H,38,43)	IFPDRGUZVMVZSF-UHFFFAOYSA-N	363691	US9850277, Compound 178::US10689414, Compound 178::US10640534, Compound 178::US10717764, Compound 178::US11021515, Compound 178::US11667673, Compound 178	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363691	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363691&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699704	401959141							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720072	CC(C)(O)c1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C32H30ClF2N5O4/c1-31(2,44)20-6-5-7-22(15-20)39(30(43)25-10-11-27(41)40(25)26-14-19(18-36)12-13-37-26)28(23-8-3-4-9-24(23)33)29(42)38-21-16-32(34,35)17-21/h3-9,12-15,21,25,28,44H,10-11,16-17H2,1-2H3,(H,38,42)	HHGYXOPFMWBBIL-UHFFFAOYSA-N	363692	US9850277, Compound 179::US10689414, Compound 179::US10640534, Compound 179::US10717764, Compound 179::US11021515, Compound 179::US11667673, Compound 179	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363692	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363692&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657136	401959142							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720074	FC(F)(F)Oc1cccc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C29H22ClF5N6O4/c30-21-7-2-1-6-20(21)24(25(43)38-17-13-28(31,32)14-17)40(18-4-3-5-19(12-18)45-29(33,34)35)26(44)22-8-9-23(42)41(22)27-37-11-10-16(15-36)39-27/h1-7,10-12,17,22,24H,8-9,13-14H2,(H,38,43)	TWMOXSSMBQPSKI-UHFFFAOYSA-N	363693	US9850277, Compound 180::US10689414, Compound 180::US10640534, Compound 180::US10717764, Compound 180::US11021515, Compound 180::US11667673, Compound 180	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363693	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363693&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89700031	401959143							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720076	FC(F)Oc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H24ClF4N5O4/c31-22-7-2-1-6-21(22)26(27(42)38-18-14-30(34,35)15-18)39(19-4-3-5-20(13-19)44-29(32)33)28(43)23-8-9-25(41)40(23)24-12-17(16-36)10-11-37-24/h1-7,10-13,18,23,26,29H,8-9,14-15H2,(H,38,42)	IQBNCPMUMOBIBD-UHFFFAOYSA-N	363694	US9850277, Compound 181::US10689414, Compound 181::US10717764, Compound 181::US11021515, Compound 181::US11667673, Compound 181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363694&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699515	401959144							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720078	FC1(F)CC(C1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N)c1cccc(c1)C1CC1)c1ccccc1Cl |r|	InChI=1S/C31H27ClF2N6O3/c32-24-7-2-1-6-23(24)27(28(42)37-21-15-31(33,34)16-21)39(22-5-3-4-19(14-22)18-8-9-18)29(43)25-10-11-26(41)40(25)30-36-13-12-20(17-35)38-30/h1-7,12-14,18,21,25,27H,8-11,15-16H2,(H,37,42)	NEEFZHLDHWRLNC-UHFFFAOYSA-N	363695	US9850277, Compound 182::US10689414, Compound 182::US10640534, Compound 182::US10717764, Compound 182::US11021515, Compound 182::US11667673, Compound 182	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363695	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363695&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699532	401959145							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720079	C[C@]1(O)C[C@H](N(C1=O)c1cc(ccn1)C#N)C(=O)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C30H25ClF3N5O4/c1-29(43)15-23(39(28(29)42)24-11-17(16-35)9-10-36-24)27(41)38(20-6-4-5-18(32)12-20)25(21-7-2-3-8-22(21)31)26(40)37-19-13-30(33,34)14-19/h2-12,19,23,25,43H,13-15H2,1H3,(H,37,40)	QTQLWUCZZASUFU-UHFFFAOYSA-N	363696	US9850277, Compound 183::US10689414, Compound 183::US10717764, Compound 183::US11021515, Compound 183::US11667673, Compound 183	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363696&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657242	401959146							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720081	Fc1cc(cc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)C#N |r|	InChI=1S/C32H26ClF3N6O3/c33-25-4-2-1-3-24(25)29(30(44)40-22-7-10-32(35,36)11-8-22)41(23-14-20(18-38)13-21(34)16-23)31(45)26-5-6-28(43)42(26)27-15-19(17-37)9-12-39-27/h1-4,9,12-16,22,26,29H,5-8,10-11H2,(H,40,44)	LNGNGQRPGYSXLQ-UHFFFAOYSA-N	363697	US9850277, Compound 184::US10689414, Compound 184::US10640534, Compound 184::US10717764, Compound 184::US11021515, Compound 184::US11667673, Compound 184	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363697	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363697&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657243	401959147							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720083	Fc1cc(cc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N)C#N |r|	InChI=1S/C31H25ClF3N7O3/c32-24-4-2-1-3-23(24)27(28(44)39-20-7-10-31(34,35)11-8-20)41(22-14-18(16-36)13-19(33)15-22)29(45)25-5-6-26(43)42(25)30-38-12-9-21(17-37)40-30/h1-4,9,12-15,20,25,27H,5-8,10-11H2,(H,39,44)	YFPRYFOHOGEFQY-UHFFFAOYSA-N	363698	US9850277, Compound 185::US10689414, Compound 185::US10640534, Compound 185::US10717764, Compound 185::US11021515, Compound 185::US11667673, Compound 185	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363698	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363698&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657348	401959148							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720085	FC1(F)CC(C1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cccc2cn[nH]c12)c1ccccc1Cl |r|	InChI=1S/C30H24ClF2N7O3/c31-21-6-2-1-5-20(21)27(28(42)37-19-13-30(32,33)14-19)40(22-7-3-4-18-16-36-38-26(18)22)29(43)23-8-9-25(41)39(23)24-12-17(15-34)10-11-35-24/h1-7,10-12,16,19,23,27H,8-9,13-14H2,(H,36,38)(H,37,42)	JVKSHAPFLQYINL-UHFFFAOYSA-N	363699	US9850277, Compound 186::US10689414, Compound 186::US11021515, Compound 186::US11667673, Compound 186	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363699	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363699&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657349	401959149							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720087	Fc1ccccc1N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H23ClF3N5O3/c30-20-6-2-1-5-19(20)26(27(40)36-18-14-29(32,33)15-18)38(22-8-4-3-7-21(22)31)28(41)23-9-10-25(39)37(23)24-13-17(16-34)11-12-35-24/h1-8,11-13,18,23,26H,9-10,14-15H2,(H,36,40)	WZQDKINHBLUCPG-UHFFFAOYSA-N	363700	US9850277, Compound 187::US10689414, Compound 187::US10640534, Compound 187::US10717764, Compound 187::US11021515, Compound 187::US11667673, Compound 187	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363700	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363700&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657039	401959150							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720089	Fc1cccc(N([C@H](C(=O)NC2CC(F)(F)C2)c2ccccc2Cl)C(=O)[C@@H]2CCC(=O)N2c2cc(ccn2)C#N)c1F |r|	InChI=1S/C29H22ClF4N5O3/c30-19-5-2-1-4-18(19)26(27(41)37-17-13-29(33,34)14-17)39(21-7-3-6-20(31)25(21)32)28(42)22-8-9-24(40)38(22)23-12-16(15-35)10-11-36-23/h1-7,10-12,17,22,26H,8-9,13-14H2,(H,37,41)	AFVGQWQJMPQEFQ-UHFFFAOYSA-N	363701	US9850277, Compound 188::US10689414, Compound 188::US10640534, Compound 188::US10717764, Compound 188::US11021515, Compound 188::US11667673, Compound 188	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363701	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363701&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657040	401959151							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720090	O[C@H]1C[C@H](N(C1=O)c1nccc(n1)C#N)C(=O)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)c1cccc(F)c1 |r|	InChI=1S/C30H26ClF3N6O4/c31-22-7-2-1-6-21(22)25(26(42)37-18-8-11-30(33,34)12-9-18)39(20-5-3-4-17(32)14-20)27(43)23-15-24(41)28(44)40(23)29-36-13-10-19(16-35)38-29/h1-7,10,13-14,18,23-25,41H,8-9,11-12,15H2,(H,37,42)	LHIJKVKSIGTZTB-UHFFFAOYSA-N	363702	US9850277, Compound 189::US10689414, Compound 189::US10640534, Compound 189::US10717764, Compound 189::US11021515, Compound 189::US11667673, Compound 189	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363702	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363702&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89700059	401959152							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720092	C[S@](=O)c1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H25ClF3N5O4S/c1-44(43)21-12-18(32)11-20(13-21)38(29(42)24-6-7-26(40)39(24)25-10-17(16-35)8-9-36-25)27(22-4-2-3-5-23(22)31)28(41)37-19-14-30(33,34)15-19/h2-5,8-13,19,24,27H,6-7,14-15H2,1H3,(H,37,41)	HAJLXEGWTKLTAE-UHFFFAOYSA-N	363703	US9850277, Compound 190::US10689414, Compound 190::US10640534, Compound 190::US10717764, Compound 190::US11021515, Compound 190::US11667673, Compound 190	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363703	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363703&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657042	401959153							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720094	FC1(F)CC(C1)NC(=O)C(N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cc(cc(c1)C#N)C#N)c1ccccc1Cl |r|	InChI=1S/C31H22ClF2N7O3/c32-24-4-2-1-3-23(24)28(29(43)39-21-13-31(33,34)14-21)40(22-10-19(16-36)9-20(11-22)17-37)30(44)25-5-6-27(42)41(25)26-12-18(15-35)7-8-38-26/h1-4,7-12,21,25,28H,5-6,13-14H2,(H,39,43)	JVZLOTLFFCFWBA-UHFFFAOYSA-N	363704	US9850277, Compound 191::US10689414, Compound 191::US10640534, Compound 191::US10717764, Compound 191::US11021515, Compound 191::US11667673, Compound 191	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363704	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363704&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			86690602	401959154							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720095	FC1(F)CC(C1)NC(=O)C(N(C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N)c1cccc(OC2CC2)c1)c1ccccc1Cl |r|	InChI=1S/C31H27ClF2N6O4/c32-24-7-2-1-6-23(24)27(28(42)37-19-15-31(33,34)16-19)39(20-4-3-5-22(14-20)44-21-8-9-21)29(43)25-10-11-26(41)40(25)30-36-13-12-18(17-35)38-30/h1-7,12-14,19,21,25,27H,8-11,15-16H2,(H,37,42)	LCKHBSJSTWNGHH-UHFFFAOYSA-N	363705	US9850277, Compound 192::US10689414, Compound 192::US10640534, Compound 192::US11667673, Compound 192	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363705	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363705&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699541	401959155							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720097	Fc1cncc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H26ClF3N6O3/c31-23-4-2-1-3-22(23)27(28(42)38-20-7-10-30(33,34)11-8-20)39(21-14-19(32)16-36-17-21)29(43)24-5-6-26(41)40(24)25-13-18(15-35)9-12-37-25/h1-4,9,12-14,16-17,20,24,27H,5-8,10-11H2,(H,38,42)	LPPNMHGIZPKQMV-UHFFFAOYSA-N	363706	US9850277, Compound 193::US10689414, Compound 193::US10640534, Compound 193::US10717764, Compound 193::US11021515, Compound 193::US11667673, Compound 193	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363706	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363706&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699756	401959156							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720098	FC(F)Oc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1nccc(n1)C#N |r|	InChI=1S/C29H23ClF4N6O4/c30-21-7-2-1-6-20(21)24(25(42)37-17-13-29(33,34)14-17)39(18-4-3-5-19(12-18)44-27(31)32)26(43)22-8-9-23(41)40(22)28-36-11-10-16(15-35)38-28/h1-7,10-12,17,22,24,27H,8-9,13-14H2,(H,37,42)	GZRVPCGRUARFDO-UHFFFAOYSA-N	363707	US9850277, Compound 194::US10689414, Compound 194::US10640534, Compound 194::US10717764, Compound 194::US11021515, Compound 194::US11667673, Compound 194	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363707	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363707&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71657135	401959157							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720099	Fc1cc(F)cc(c1)N(C(C(=O)NC1CC(F)(F)C1)c1cccc(Cl)c1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H21Cl2F4N5O3/c30-21-3-1-2-20(25(21)31)26(27(42)38-18-12-29(34,35)13-18)39(19-10-16(32)9-17(33)11-19)28(43)22-4-5-24(41)40(22)23-8-15(14-36)6-7-37-23/h1-3,6-11,18,22,26H,4-5,12-13H2,(H,38,42)	UDHLJFCCLROXQY-UHFFFAOYSA-N	363708	US9850277, Compound 195::US10689414, Compound 195::US10640534, Compound 195::US10717764, Compound 195::US11021515, Compound 195::US11667673, Compound 195	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363708	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363708&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699943	401959158							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720100	Fc1cccc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccc(Cl)cc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H22Cl2F3N5O3/c30-17-4-5-21(22(31)11-17)26(27(41)37-19-13-29(33,34)14-19)38(20-3-1-2-18(32)12-20)28(42)23-6-7-25(40)39(23)24-10-16(15-35)8-9-36-24/h1-5,8-12,19,23,26H,6-7,13-14H2,(H,37,41)	YZMXTYKDFCKYEG-UHFFFAOYSA-N	363709	US9850277, Compound 196	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363709	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363709&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124198865	401959159							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720102	Fc1ccc(F)c(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H22ClF4N5O3/c30-20-4-2-1-3-19(20)26(27(41)37-18-13-29(33,34)14-18)39(23-12-17(31)5-6-21(23)32)28(42)22-7-8-25(40)38(22)24-11-16(15-35)9-10-36-24/h1-6,9-12,18,22,26H,7-8,13-14H2,(H,37,41)	QRPVHYKENSGVGR-UHFFFAOYSA-N	363710	US9850277, Compound 197::US10689414, Compound 197::US10640534, Compound 197::US10717764, Compound 197::US11021515, Compound 197::US11667673, Compound 197	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363710	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363710&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699680	401959160							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720104	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ncccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C28H21ClF4N6O3/c29-20-2-1-6-36-24(20)25(26(41)37-18-12-28(32,33)13-18)38(19-10-16(30)9-17(31)11-19)27(42)21-3-4-23(40)39(21)22-8-15(14-34)5-7-35-22/h1-2,5-11,18,21,25H,3-4,12-13H2,(H,37,41)	NXJFKNDGZLGJNN-UHFFFAOYSA-N	363711	US9850277, Compound 198::US10689414, Compound 198::US10640534, Compound 198::US10717764, Compound 198::US11021515, Compound 198::US11667673, Compound 198	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363711	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363711&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656674	401959161							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720106	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1c(Cl)cccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H21Cl2F4N5O3/c30-20-2-1-3-21(31)25(20)26(27(42)38-18-12-29(34,35)13-18)39(19-10-16(32)9-17(33)11-19)28(43)22-4-5-24(41)40(22)23-8-15(14-36)6-7-37-23/h1-3,6-11,18,22,26H,4-5,12-13H2,(H,38,42)	TZAMEDXGVYYPDI-UHFFFAOYSA-N	363712	US9850277, Compound 199::US10689414, Compound 199::US10640534, Compound 199::US10717764, Compound 199::US11021515, Compound 199::US11667673, Compound 199	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363712	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363712&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699450	401959162							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720108	FC1(F)CC(C1)NC(=O)C(N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cccc(c1)-c1cn[nH]c1)c1ccccc1Cl |r|	InChI=1S/C32H26ClF2N7O3/c33-25-7-2-1-6-24(25)29(30(44)40-22-14-32(34,35)15-22)41(23-5-3-4-20(13-23)21-17-38-39-18-21)31(45)26-8-9-28(43)42(26)27-12-19(16-36)10-11-37-27/h1-7,10-13,17-18,22,26,29H,8-9,14-15H2,(H,38,39)(H,40,44)	FTHDRVINJMQWNE-UHFFFAOYSA-N	363713	US9850277, Compound 200::US10689414, Compound 200::US10640534, Compound 200::US10717764, Compound 200::US11021515, Compound 200::US11667673, Compound 200	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363713	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363713&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656947	401959163							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720110	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1cc(Cl)ccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H21Cl2F4N5O3/c30-16-1-2-22(31)21(8-16)26(27(42)38-19-12-29(34,35)13-19)39(20-10-17(32)9-18(33)11-20)28(43)23-3-4-25(41)40(23)24-7-15(14-36)5-6-37-24/h1-2,5-11,19,23,26H,3-4,12-13H2,(H,38,42)	ZIMWCPCYVIIWAW-UHFFFAOYSA-N	363714	US9850277, Compound 201::US10689414, Compound 201::US10640534, Compound 201::US10717764, Compound 201::US11021515, Compound 201::US11667673, Compound 201	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363714	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363714&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699755	401959164							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720111	Fc1cc(cc(c1)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)C1CC1 |r|	InChI=1S/C34H31ClF3N5O3/c35-27-4-2-1-3-26(27)31(32(45)41-24-9-12-34(37,38)13-10-24)42(25-17-22(21-5-6-21)16-23(36)18-25)33(46)28-7-8-30(44)43(28)29-15-20(19-39)11-14-40-29/h1-4,11,14-18,21,24,28,31H,5-10,12-13H2,(H,41,45)	HXUUXRVUQAIDJU-UHFFFAOYSA-N	363715	US9850277, Compound 202::US10689414, Compound 202::US10640534, Compound 202::US10717764, Compound 202::US11021515, Compound 202::US11667673, Compound 202	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363715	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363715&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656949	401959165							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720112	FC1(F)CCC(CC1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1ccc2[nH]ncc2c1)c1ccccc1Cl |r|	InChI=1S/C32H28ClF2N7O3/c33-24-4-2-1-3-23(24)29(30(44)39-21-9-12-32(34,35)13-10-21)41(22-5-6-25-20(16-22)18-38-40-25)31(45)26-7-8-28(43)42(26)27-15-19(17-36)11-14-37-27/h1-6,11,14-16,18,21,26,29H,7-10,12-13H2,(H,38,40)(H,39,44)	WTWOOWRCZBZFQA-UHFFFAOYSA-N	363716	US9850277, Compound 203::US10689414, Compound 203::US10640534, Compound 203::US10717764, Compound 203::US11021515, Compound 203::US11667673, Compound 203	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363716	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363716&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699601	401959166							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720114	Fc1cc(cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)C1CC1 |r|	InChI=1S/C32H27ClF3N5O3/c33-25-4-2-1-3-24(25)29(30(43)39-22-15-32(35,36)16-22)40(23-13-20(19-5-6-19)12-21(34)14-23)31(44)26-7-8-28(42)41(26)27-11-18(17-37)9-10-38-27/h1-4,9-14,19,22,26,29H,5-8,15-16H2,(H,39,43)	MNGWSCAYBGMVFJ-UHFFFAOYSA-N	363717	US9850277, Compound 204::US10689414, Compound 204::US10640534, Compound 204::US10717764, Compound 204::US11021515, Compound 204::US11667673, Compound 204	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363717	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363717&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699487	401959167							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720116	Fc1cc(cc2cn[nH]c12)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C30H23ClF3N7O3/c31-21-4-2-1-3-20(21)27(28(43)38-18-12-30(33,34)13-18)40(19-10-17-15-37-39-26(17)22(32)11-19)29(44)23-5-6-25(42)41(23)24-9-16(14-35)7-8-36-24/h1-4,7-11,15,18,23,27H,5-6,12-13H2,(H,37,39)(H,38,43)	YNIOAKDCKQDEIA-UHFFFAOYSA-N	363718	US9850277, Compound 205::US10689414, Compound 205::US10640534, Compound 205::US10717764, Compound 205::US11021515, Compound 205::US11667673, Compound 205	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363718	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363718&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707942	401959168							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720117	FC1(F)CC(C1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1ccc2[nH]ccc2c1)c1ccccc1Cl |r|	InChI=1S/C31H25ClF2N6O3/c32-23-4-2-1-3-22(23)28(29(42)38-20-15-31(33,34)16-20)39(21-5-6-24-19(14-21)10-12-36-24)30(43)25-7-8-27(41)40(25)26-13-18(17-35)9-11-37-26/h1-6,9-14,20,25,28,36H,7-8,15-16H2,(H,38,42)	GTURXNXSFFEDJK-UHFFFAOYSA-N	363719	US9850277, Compound 206::US10689414, Compound 206::US10640534, Compound 206::US10717764, Compound 206::US11021515, Compound 206::US11667673, Compound 206	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363719&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699491	401959169							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720119	Fc1cc(cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1F)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)C#N |r|	InChI=1S/C30H22F4N6O3/c31-19-9-18(16-36)10-21(12-19)39(29(43)24-5-6-26(41)40(24)25-11-17(15-35)7-8-37-25)27(22-3-1-2-4-23(22)32)28(42)38-20-13-30(33,34)14-20/h1-4,7-12,20,24,27H,5-6,13-14H2,(H,38,42)	DRVUZEMPTKEPSZ-UHFFFAOYSA-N	363720	US9850277, Compound 207::US10689414, Compound 207::US10640534, Compound 208::US10717764, Compound 207::US11021515, Compound 207::US11667673, Compound 207	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363720	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363720&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699853	401959170							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720121	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1F)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H22F5N5O3/c30-17-10-18(31)12-20(11-17)38(28(42)23-5-6-25(40)39(23)24-9-16(15-35)7-8-36-24)26(21-3-1-2-4-22(21)32)27(41)37-19-13-29(33,34)14-19/h1-4,7-12,19,23,26H,5-6,13-14H2,(H,37,41)	CSUCANDZUTVXIB-UHFFFAOYSA-N	363721	US9850277, Compound 208::US10689414, Compound 208::US10717764, Compound 208::US11021515, Compound 208::US11667673, Compound 208	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363721&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699570	401959171							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720123	Cn1ccc2cc(ccc12)N(C(C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C32H27ClF2N6O3/c1-39-13-11-20-15-22(6-7-25(20)39)40(31(44)26-8-9-28(42)41(26)27-14-19(18-36)10-12-37-27)29(23-4-2-3-5-24(23)33)30(43)38-21-16-32(34,35)17-21/h2-7,10-15,21,26,29H,8-9,16-17H2,1H3,(H,38,43)	YDLXHMNHTCETPG-UHFFFAOYSA-N	363722	US9850277, Compound 209	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363722	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363722&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124193799	401959172							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720125	Fc1cc(F)cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C29H23F4N5O3/c30-19-11-20(31)13-22(12-19)37(26(18-4-2-1-3-5-18)27(40)36-21-14-29(32,33)15-21)28(41)23-6-7-25(39)38(23)24-10-17(16-34)8-9-35-24/h1-5,8-13,21,23,26H,6-7,14-15H2,(H,36,40)	GSVHDCFGWNYGKB-UHFFFAOYSA-N	363723	US9850277, Compound 210::US10689414, Compound 210::US10640534, Compound 210::US10717764, Compound 210::US11021515, Compound 210::US11667673, Compound 210	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363723	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363723&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			71656948	401959173							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720127	Fc1cc(cc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)C#N |r|	InChI=1S/C30H23F3N6O3/c31-21-10-19(17-35)11-23(13-21)38(27(20-4-2-1-3-5-20)28(41)37-22-14-30(32,33)15-22)29(42)24-6-7-26(40)39(24)25-12-18(16-34)8-9-36-25/h1-5,8-13,22,24,27H,6-7,14-15H2,(H,37,41)	YWBPCKHECALHTK-UHFFFAOYSA-N	363724	US9850277, Compound 211::US10689414, Compound 211::US10640534, Compound 211::US10717764, Compound 211::US11021515, Compound 211::US11667673, Compound 211	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363724&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89699948	401959174							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
720129	FC1(F)CC(C1)NC(=O)[C@@H](N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cncc(c1)C#N)c1ccccc1 |r|	InChI=1S/C29H23F2N7O3/c30-29(31)12-21(13-29)36-27(40)26(20-4-2-1-3-5-20)37(22-10-19(15-33)16-34-17-22)28(41)23-6-7-25(39)38(23)24-11-18(14-32)8-9-35-24/h1-5,8-11,16-17,21,23,26H,6-7,12-13H2,(H,36,40)	HVVOBLPWJZTTAM-UHFFFAOYSA-N	363725	US9850277, Compound 212::US10689414, Compound 212::US10640534, Compound 212::US10717764, Compound 212::US11021515, Compound 212::US11667673, Compound 212	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<500							US Patent		10.7270/Q24170CS		aid1797917	US9850277	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	12/26/2017	11/14/2019	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=363725	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=363725&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			89707963	401959175							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746428	COc1cc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C18H15ClN4O2/c1-10(22-17-7-16(25-2)12(8-20)9-21-17)14-6-11-5-13(19)3-4-15(11)23-18(14)24/h3-7,9-10H,1-2H3,(H,21,22)(H,23,24)	ATBYPAVFMVZPHR-UHFFFAOYSA-N	375141	6-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375141	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375141&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866101	404344187							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746430	COc1cc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C18H15ClN4O2/c1-10(22-17-7-16(25-2)12(8-20)9-21-17)14-6-11-5-13(19)3-4-15(11)23-18(14)24/h3-7,9-10H,1-2H3,(H,21,22)(H,23,24)	ATBYPAVFMVZPHR-UHFFFAOYSA-N	375141	6-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375141	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375141&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866101	404344187							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746432	COc1cc(N[C@@H](C)c2cc3cc(Cl)ccc3n(C)c2=O)ncc1C#N |r|	InChI=1S/C19H17ClN4O2/c1-11(23-18-8-17(26-3)13(9-21)10-22-18)15-7-12-6-14(20)4-5-16(12)24(2)19(15)25/h4-8,10-11H,1-3H3,(H,22,23)	RXDHNCUXTNJIDV-UHFFFAOYSA-N	375142	6-{[(1S)-1-(6-chloro-1-::US10253015, Compound I-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375142	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375142&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118956165	404344188							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746434	COc1cc(N[C@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C18H15ClN4O2/c1-10(22-17-7-16(25-2)12(8-20)9-21-17)14-6-11-5-13(19)3-4-15(11)23-18(14)24/h3-7,9-10H,1-2H3,(H,21,22)(H,23,24)	ATBYPAVFMVZPHR-UHFFFAOYSA-N	375143	6-{[(1R)-1-(6-chloro-2-::US10253015, Compound I-3	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375143	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375143&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866102	404344189							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746436	C[C@H](Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H15ClN4O/c1-10-12(9-20)3-6-17(21-10)22-11(2)15-8-13-7-14(19)4-5-16(13)23-18(15)24/h3-8,11H,1-2H3,(H,21,22)(H,23,24)	DRQHRPOTAKQHEV-UHFFFAOYSA-N	375144	6-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375144	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375144&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866103	404344190							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746438	C[C@H](Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H15ClN4O/c1-10-12(9-20)3-6-17(21-10)22-11(2)15-8-13-7-14(19)4-5-16(13)23-18(15)24/h3-8,11H,1-2H3,(H,21,22)(H,23,24)	DRQHRPOTAKQHEV-UHFFFAOYSA-N	375144	6-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375144	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375144&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866103	404344190							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746440	C[C@H](Nc1cc(C)c(cn1)C#N)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H15ClN4O/c1-10-5-17(21-9-13(10)8-20)22-11(2)15-7-12-6-14(19)3-4-16(12)23-18(15)24/h3-7,9,11H,1-2H3,(H,21,22)(H,23,24)	APLSHCOQIQKKJA-UHFFFAOYSA-N	375145	6-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375145	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375145&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866104	404344191							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746442	C[C@H](Nc1cc(C)c(cn1)C#N)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H15ClN4O/c1-10-5-17(21-9-13(10)8-20)22-11(2)15-7-12-6-14(19)3-4-16(12)23-18(15)24/h3-7,9,11H,1-2H3,(H,21,22)(H,23,24)	APLSHCOQIQKKJA-UHFFFAOYSA-N	375145	6-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375145	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375145&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866104	404344191							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746444	COc1nc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N |r|	InChI=1S/C18H15ClN4O2/c1-10(21-16-6-3-11(9-20)18(23-16)25-2)14-8-12-7-13(19)4-5-15(12)22-17(14)24/h3-8,10H,1-2H3,(H,21,23)(H,22,24)	GODRNGSVIZIHOY-UHFFFAOYSA-N	375146	6-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-6	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375146	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375146&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866105	404344192							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746446	COc1nc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N |r|	InChI=1S/C18H15ClN4O2/c1-10(21-16-6-3-11(9-20)18(23-16)25-2)14-8-12-7-13(19)4-5-15(12)22-17(14)24/h3-8,10H,1-2H3,(H,21,23)(H,22,24)	GODRNGSVIZIHOY-UHFFFAOYSA-N	375146	6-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-6	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375146	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375146&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866105	404344192							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746448	COc1nc(ccc1N[C@@H](C)c1cc2cc(Cl)ccc2[nH]c1=O)C#N |r|	InChI=1S/C18H15ClN4O2/c1-10(21-16-6-4-13(9-20)22-18(16)25-2)14-8-11-7-12(19)3-5-15(11)23-17(14)24/h3-8,10,21H,1-2H3,(H,23,24)	LXAVQRJBWNUBTP-UHFFFAOYSA-N	375147	5-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375147	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375147&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866106	404344193							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746450	COc1nc(ccc1N[C@@H](C)c1cc2cc(Cl)ccc2[nH]c1=O)C#N |r|	InChI=1S/C18H15ClN4O2/c1-10(21-16-6-4-13(9-20)22-18(16)25-2)14-8-11-7-12(19)3-5-15(11)23-17(14)24/h3-8,10,21H,1-2H3,(H,23,24)	LXAVQRJBWNUBTP-UHFFFAOYSA-N	375147	5-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375147	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375147&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866106	404344193							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746452	C[C@@H](Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H15ClN4O/c1-10-12(9-20)3-6-17(21-10)22-11(2)15-8-13-7-14(19)4-5-16(13)23-18(15)24/h3-8,11H,1-2H3,(H,21,22)(H,23,24)	DRQHRPOTAKQHEV-UHFFFAOYSA-N	375148	6-{[(1R)-1-(6-chloro-2-::US10253015, Compound I-8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375148	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375148&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866107	404344194							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746453	CC(Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)ccc2[nH]c1=O	InChI=1S/C18H15ClN4O/c1-10-12(9-20)3-6-17(21-10)22-11(2)15-8-13-7-14(19)4-5-16(13)23-18(15)24/h3-8,11H,1-2H3,(H,21,22)(H,23,24)	DRQHRPOTAKQHEV-UHFFFAOYSA-N	375149	6-{[1-(6-chloro-2-oxo-::US10253015, Compound I-9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375149	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375149&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866108	404344195							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746455	CC(Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)ccc2[nH]c1=O	InChI=1S/C18H15ClN4O/c1-10-12(9-20)3-6-17(21-10)22-11(2)15-8-13-7-14(19)4-5-16(13)23-18(15)24/h3-8,11H,1-2H3,(H,21,22)(H,23,24)	DRQHRPOTAKQHEV-UHFFFAOYSA-N	375149	6-{[1-(6-chloro-2-oxo-::US10253015, Compound I-9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375149	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375149&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866108	404344195							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746457	C[C@H](Nc1cc(ccn1)N1CCOC1=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H17ClN4O3/c1-11(15-9-12-8-13(20)2-3-16(12)23-18(15)25)22-17-10-14(4-5-21-17)24-6-7-27-19(24)26/h2-5,8-11H,6-7H2,1H3,(H,21,22)(H,23,25)	BOLKOIMIOCFWLZ-UHFFFAOYSA-N	375150	6-chloro-3-[(1S)-1-{[4-(2-::US10253015, Compound I-10	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375150	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375150&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866109	404344196							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746459	C[C@H](Nc1cccc(n1)N1CCOC1=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H17ClN4O3/c1-11(14-10-12-9-13(20)5-6-15(12)22-18(14)25)21-16-3-2-4-17(23-16)24-7-8-27-19(24)26/h2-6,9-11H,7-8H2,1H3,(H,21,23)(H,22,25)	RNAUWLUZXNUTMK-UHFFFAOYSA-N	375151	6-chloro-3-[(1S)-1-{[6-(2-::US10253015, Compound I-11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375151	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375151&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866110	404344197							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746461	C[C@H](Nc1cccc(n1)N1CCOC1=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H17ClN4O3/c1-11(14-10-12-9-13(20)5-6-15(12)22-18(14)25)21-16-3-2-4-17(23-16)24-7-8-27-19(24)26/h2-6,9-11H,7-8H2,1H3,(H,21,23)(H,22,25)	RNAUWLUZXNUTMK-UHFFFAOYSA-N	375151	6-chloro-3-[(1S)-1-{[6-(2-::US10253015, Compound I-11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375151	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375151&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866110	404344197							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746463	C[C@H](Nc1cc(cc(C)n1)N1CCOC1=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H19ClN4O3/c1-11-7-15(25-5-6-28-20(25)27)10-18(22-11)23-12(2)16-9-13-8-14(21)3-4-17(13)24-19(16)26/h3-4,7-10,12H,5-6H2,1-2H3,(H,22,23)(H,24,26)	HYLFAZRHAPPLDU-UHFFFAOYSA-N	375152	6-chloro-3-[(1S)-1-{[6-::US10253015, Compound I-12	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375152	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375152&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866111	404344198							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746464	C[C@H](Nc1cc(ccn1)N1C(=O)OCC1(C)C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H21ClN4O3/c1-12(16-9-13-8-14(22)4-5-17(13)25-19(16)27)24-18-10-15(6-7-23-18)26-20(28)29-11-21(26,2)3/h4-10,12H,11H2,1-3H3,(H,23,24)(H,25,27)	AJYIONBIQGQQEY-UHFFFAOYSA-N	375153	6-chloro-3-[(1S)-1-{[4-(4,4-::US10253015, Compound I-13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375153	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375153&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866112	404344199							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746466	C[C@H](Nc1nccc(N2CCOC2=O)c1F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H16ClFN4O3/c1-10(13-9-11-8-12(20)2-3-14(11)24-18(13)26)23-17-16(21)15(4-5-22-17)25-6-7-28-19(25)27/h2-5,8-10H,6-7H2,1H3,(H,22,23)(H,24,26)	SOOZHBULFSDQIK-UHFFFAOYSA-N	375154	6-chloro-3-[(1S)-1-{[3-::US10253015, Compound I-14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375154	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375154&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866113	404344200							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746468	C[C@H](Nc1nccc(N2CCOC2=O)c1F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H16ClFN4O3/c1-10(13-9-11-8-12(20)2-3-14(11)24-18(13)26)23-17-16(21)15(4-5-22-17)25-6-7-28-19(25)27/h2-5,8-10H,6-7H2,1H3,(H,22,23)(H,24,26)	SOOZHBULFSDQIK-UHFFFAOYSA-N	375154	6-chloro-3-[(1S)-1-{[3-::US10253015, Compound I-14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375154	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375154&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866113	404344200							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746470	C[C@H](Nc1nccc(N2CCOC2=O)c1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H19ClN4O3/c1-11-17(25-7-8-28-20(25)27)5-6-22-18(11)23-12(2)15-10-13-9-14(21)3-4-16(13)24-19(15)26/h3-6,9-10,12H,7-8H2,1-2H3,(H,22,23)(H,24,26)	JBGAOSNLUALWMJ-UHFFFAOYSA-N	375155	6-chloro-3-[(1S)-1-{[3-::US10253015, Compound I-15	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375155	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375155&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866114	404344201							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746471	C[C@H](Nc1cc(F)cc(n1)N1CCOC1=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H16ClFN4O3/c1-10(14-7-11-6-12(20)2-3-15(11)23-18(14)26)22-16-8-13(21)9-17(24-16)25-4-5-28-19(25)27/h2-3,6-10H,4-5H2,1H3,(H,22,24)(H,23,26)	VZPSTPGZDJIVID-UHFFFAOYSA-N	375156	6-chloro-3-[(1S)-1-{[4-::US10253015, Compound I-16	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375156	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375156&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866115	404344202							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746472	C[C@H](Nc1cc(cc(F)n1)N1COCC1=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H16ClFN4O3/c1-10(14-5-11-4-12(20)2-3-15(11)23-19(14)27)22-17-7-13(6-16(21)24-17)25-9-28-8-18(25)26/h2-7,10H,8-9H2,1H3,(H,22,24)(H,23,27)	OLXKFTKDYVWZBH-UHFFFAOYSA-N	375157	6-chloro-3-[(1S)-1-{[6-::US10253015, Compound I-17	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375157	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375157&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866116	404344203							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746473	CC(C)[C@H]1COC(=O)N1c1ccnc(NC(C)c2cc3cc(Cl)ccc3[nH]c2=O)c1 |r|	InChI=1S/C22H23ClN4O3/c1-12(2)19-11-30-22(29)27(19)16-6-7-24-20(10-16)25-13(3)17-9-14-8-15(23)4-5-18(14)26-21(17)28/h4-10,12-13,19H,11H2,1-3H3,(H,24,25)(H,26,28)	MEMPGRIFXZBEDA-UHFFFAOYSA-N	375158	6-chloro-3-[1-({4-[(4S)-2-::US10253015, Compound I-18	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375158	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375158&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866117	404344204							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746475	CC(C)[C@H]1COC(=O)N1c1cccc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C22H23ClN4O3/c1-12(2)18-11-30-22(29)27(18)20-6-4-5-19(26-20)24-13(3)16-10-14-9-15(23)7-8-17(14)25-21(16)28/h4-10,12-13,18H,11H2,1-3H3,(H,24,26)(H,25,28)	IAEUARYYOPFFRD-UHFFFAOYSA-N	375159	6-chloro-3-[(1S)-1-({6-::US10253015, Compound I-19	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375159	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375159&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866118	404344205							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746477	CC(C)[C@H]1COC(=O)N1c1cccc(N[C@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C22H23ClN4O3/c1-12(2)18-11-30-22(29)27(18)20-6-4-5-19(26-20)24-13(3)16-10-14-9-15(23)7-8-17(14)25-21(16)28/h4-10,12-13,18H,11H2,1-3H3,(H,24,26)(H,25,28)	IAEUARYYOPFFRD-UHFFFAOYSA-N	375160	6-chloro-3-[(1R)-1-({6-::US10253015, Compound I-20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375160	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375160&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866119	404344206							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746478	CC(Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(F)cc2[nH]c1=O	InChI=1S/C18H14ClFN4O/c1-9-11(8-21)3-4-17(22-9)23-10(2)13-5-12-6-14(19)15(20)7-16(12)24-18(13)25/h3-7,10H,1-2H3,(H,22,23)(H,24,25)	ZDLSZHBGHIPTJF-UHFFFAOYSA-N	375161	6-{[1-(6-chloro-7-fluoro-2-::US10253015, Compound I-21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375161	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375161&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866120	404344207							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746480	CC(Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(F)cc2[nH]c1=O	InChI=1S/C18H14ClFN4O/c1-9-11(8-21)3-4-17(22-9)23-10(2)13-5-12-6-14(19)15(20)7-16(12)24-18(13)25/h3-7,10H,1-2H3,(H,22,23)(H,24,25)	ZDLSZHBGHIPTJF-UHFFFAOYSA-N	375161	6-{[1-(6-chloro-7-fluoro-2-::US10253015, Compound I-21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375161	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375161&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866120	404344207							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746482	C[C@H](Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(F)cc2[nH]c1=O |r|	InChI=1S/C18H14ClFN4O/c1-9-11(8-21)3-4-17(22-9)23-10(2)13-5-12-6-14(19)15(20)7-16(12)24-18(13)25/h3-7,10H,1-2H3,(H,22,23)(H,24,25)	ZDLSZHBGHIPTJF-UHFFFAOYSA-N	375162	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375162	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375162&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866121	404344208							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746484	C[C@H](Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(F)cc2[nH]c1=O |r|	InChI=1S/C18H14ClFN4O/c1-9-11(8-21)3-4-17(22-9)23-10(2)13-5-12-6-14(19)15(20)7-16(12)24-18(13)25/h3-7,10H,1-2H3,(H,22,23)(H,24,25)	ZDLSZHBGHIPTJF-UHFFFAOYSA-N	375162	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375162	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375162&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866121	404344208							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746486	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1ccc(C#N)c(C)n1 |r|	InChI=1S/C19H17ClN4O2/c1-10-12(9-21)4-5-18(22-10)23-11(2)14-6-13-7-15(20)17(26-3)8-16(13)24-19(14)25/h4-8,11H,1-3H3,(H,22,23)(H,24,25)	MJIIMSGVGMGBRO-UHFFFAOYSA-N	375163	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-23	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375163	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375163&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866122	404344209							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746488	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1ccc(C#N)c(C)n1 |r|	InChI=1S/C19H17ClN4O2/c1-10-12(9-21)4-5-18(22-10)23-11(2)14-6-13-7-15(20)17(26-3)8-16(13)24-19(14)25/h4-8,11H,1-3H3,(H,22,23)(H,24,25)	MJIIMSGVGMGBRO-UHFFFAOYSA-N	375163	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-23	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375163	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375163&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866122	404344209							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746490	COc1cc2[nH]c(=O)c(cc2cc1Cl)C(C)Nc1ccc(C#N)c(C)n1	InChI=1S/C19H17ClN4O2/c1-10-12(9-21)4-5-18(22-10)23-11(2)14-6-13-7-15(20)17(26-3)8-16(13)24-19(14)25/h4-8,11H,1-3H3,(H,22,23)(H,24,25)	MJIIMSGVGMGBRO-UHFFFAOYSA-N	375164	6-{[1-(6-chloro-7-methoxy-::US10253015, Compound I-24	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375164	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375164&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866123	404344210							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746492	COc1cc2[nH]c(=O)c(cc2cc1Cl)C(C)Nc1ccc(C#N)c(C)n1	InChI=1S/C19H17ClN4O2/c1-10-12(9-21)4-5-18(22-10)23-11(2)14-6-13-7-15(20)17(26-3)8-16(13)24-19(14)25/h4-8,11H,1-3H3,(H,22,23)(H,24,25)	MJIIMSGVGMGBRO-UHFFFAOYSA-N	375164	6-{[1-(6-chloro-7-methoxy-::US10253015, Compound I-24	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375164	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375164&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866123	404344210							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746494	COc1cc(N[C@@H](C)c2cc3cc(Cl)c(OC)cc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C19H17ClN4O3/c1-10(23-18-7-16(26-2)12(8-21)9-22-18)13-4-11-5-14(20)17(27-3)6-15(11)24-19(13)25/h4-7,9-10H,1-3H3,(H,22,23)(H,24,25)	OMSUZXKASANRMP-UHFFFAOYSA-N	375165	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-25	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375165	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375165&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866124	404344211							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746496	COc1cc(N[C@@H](C)c2cc3cc(Cl)c(OC)cc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C19H17ClN4O3/c1-10(23-18-7-16(26-2)12(8-21)9-22-18)13-4-11-5-14(20)17(27-3)6-15(11)24-19(13)25/h4-7,9-10H,1-3H3,(H,22,23)(H,24,25)	OMSUZXKASANRMP-UHFFFAOYSA-N	375165	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-25	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375165	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375165&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866124	404344211							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746498	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1ccc(C#N)c(OC)n1 |r|	InChI=1S/C19H17ClN4O3/c1-10(22-17-5-4-11(9-21)19(24-17)27-3)13-6-12-7-14(20)16(26-2)8-15(12)23-18(13)25/h4-8,10H,1-3H3,(H,22,24)(H,23,25)	XHEZMIFLPAHWJT-UHFFFAOYSA-N	375166	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375166	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375166&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866125	404344212							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746500	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1ccc(C#N)c(OC)n1 |r|	InChI=1S/C19H17ClN4O3/c1-10(22-17-5-4-11(9-21)19(24-17)27-3)13-6-12-7-14(20)16(26-2)8-15(12)23-18(13)25/h4-8,10H,1-3H3,(H,22,24)(H,23,25)	XHEZMIFLPAHWJT-UHFFFAOYSA-N	375166	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375166	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375166&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866125	404344212							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746502	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1cc(C)c(cn1)C#N |r|	InChI=1S/C19H17ClN4O2/c1-10-4-18(22-9-13(10)8-21)23-11(2)14-5-12-6-15(20)17(26-3)7-16(12)24-19(14)25/h4-7,9,11H,1-3H3,(H,22,23)(H,24,25)	UTUVGPIHWMVGKK-UHFFFAOYSA-N	375167	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375167	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375167&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866126	404344213							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746504	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1cc(C)c(cn1)C#N |r|	InChI=1S/C19H17ClN4O2/c1-10-4-18(22-9-13(10)8-21)23-11(2)14-5-12-6-15(20)17(26-3)7-16(12)24-19(14)25/h4-7,9,11H,1-3H3,(H,22,23)(H,24,25)	UTUVGPIHWMVGKK-UHFFFAOYSA-N	375167	6-{[(1S)-1-(6-chloro-7-::US10253015, Compound I-27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375167	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375167&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866126	404344213							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746506	C[C@H](Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O |r|	InChI=1S/C24H20ClN5O2/c1-14-16(12-26)6-7-23(28-14)29-15(2)19-9-17-10-20(25)22(11-21(17)30-24(19)31)32-13-18-5-3-4-8-27-18/h3-11,15H,13H2,1-2H3,(H,28,29)(H,30,31)	BZRFFZRTDRWYGY-UHFFFAOYSA-N	375168	6-{[(1S)-1-[6-chloro-2-oxo-::US10253015, Compound I-28	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375168	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375168&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866127	404344214							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746508	C[C@H](Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O |r|	InChI=1S/C24H20ClN5O2/c1-14-16(12-26)6-7-23(28-14)29-15(2)19-9-17-10-20(25)22(11-21(17)30-24(19)31)32-13-18-5-3-4-8-27-18/h3-11,15H,13H2,1-2H3,(H,28,29)(H,30,31)	BZRFFZRTDRWYGY-UHFFFAOYSA-N	375168	6-{[(1S)-1-[6-chloro-2-oxo-::US10253015, Compound I-28	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375168	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375168&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866127	404344214							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746510	CC(Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O	InChI=1S/C24H20ClN5O2/c1-14-16(12-26)6-7-23(28-14)29-15(2)19-9-17-10-20(25)22(11-21(17)30-24(19)31)32-13-18-5-3-4-8-27-18/h3-11,15H,13H2,1-2H3,(H,28,29)(H,30,31)	BZRFFZRTDRWYGY-UHFFFAOYSA-N	375169	6-({1-[6-chloro-2-oxo-7-::US10253015, Compound I-29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375169	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375169&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866128	404344215							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746511	CC(Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O	InChI=1S/C24H20ClN5O2/c1-14-16(12-26)6-7-23(28-14)29-15(2)19-9-17-10-20(25)22(11-21(17)30-24(19)31)32-13-18-5-3-4-8-27-18/h3-11,15H,13H2,1-2H3,(H,28,29)(H,30,31)	BZRFFZRTDRWYGY-UHFFFAOYSA-N	375169	6-({1-[6-chloro-2-oxo-7-::US10253015, Compound I-29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375169	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375169&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866128	404344215							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746513	CC(Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(OCC3CC(F)(F)C3)cc2[nH]c1=O	InChI=1S/C23H21ClF2N4O2/c1-12-15(10-27)3-4-21(28-12)29-13(2)17-5-16-6-18(24)20(7-19(16)30-22(17)31)32-11-14-8-23(25,26)9-14/h3-7,13-14H,8-9,11H2,1-2H3,(H,28,29)(H,30,31)	KOQJXYKJVNZSIH-UHFFFAOYSA-N	375170	6-[(1-{6-chloro-7-[(3,3-::US10253015, Compound I-30	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375170	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375170&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866129	404344216							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746515	CC(Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(OCC3CC(F)(F)C3)cc2[nH]c1=O	InChI=1S/C23H21ClF2N4O2/c1-12-15(10-27)3-4-21(28-12)29-13(2)17-5-16-6-18(24)20(7-19(16)30-22(17)31)32-11-14-8-23(25,26)9-14/h3-7,13-14H,8-9,11H2,1-2H3,(H,28,29)(H,30,31)	KOQJXYKJVNZSIH-UHFFFAOYSA-N	375170	6-[(1-{6-chloro-7-[(3,3-::US10253015, Compound I-30	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375170	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375170&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866129	404344216							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746517	Cc1nc(NC2(CC2)c2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C19H15ClN4O/c1-11-12(10-21)2-5-17(22-11)24-19(6-7-19)15-9-13-8-14(20)3-4-16(13)23-18(15)25/h2-5,8-9H,6-7H2,1H3,(H,22,24)(H,23,25)	BLXUDHRDQAGDOD-UHFFFAOYSA-N	375171	6-{[1-(6-chloro-2-oxo-1,2-::US10253015, Compound I-31	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375171	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375171&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866130	404344217							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746518	Cc1nc(NC(C)(C)c2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C19H17ClN4O/c1-11-12(10-21)4-7-17(22-11)24-19(2,3)15-9-13-8-14(20)5-6-16(13)23-18(15)25/h4-9H,1-3H3,(H,22,24)(H,23,25)	NLNQWQNBHXXOOB-UHFFFAOYSA-N	375172	6-{[2-(6-chloro-2-oxo-1,2-::US10253015, Compound I-32	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375172	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375172&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866131	404344218							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746519	C[C@H](Nc1cc(NCCO)cc(C)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H21ClN4O2/c1-11-7-15(21-5-6-25)10-18(22-11)23-12(2)16-9-13-8-14(20)3-4-17(13)24-19(16)26/h3-4,7-10,12,25H,5-6H2,1-2H3,(H,24,26)(H2,21,22,23)	DDRFLEIGXOIQBW-UHFFFAOYSA-N	375173	6-chloro-3-[(1S)-1-({4-[(2-::US10253015, Compound I-33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375173	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375173&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866132	404344219							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746520	C[C@H](Nc1nccc(NC(C)=O)c1F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H16ClFN4O2/c1-9(22-17-16(20)15(5-6-21-17)23-10(2)25)13-8-11-7-12(19)3-4-14(11)24-18(13)26/h3-9H,1-2H3,(H,24,26)(H2,21,22,23,25)	JILJRTQNPBPZLZ-UHFFFAOYSA-N	375174	N-(2-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-34	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375174	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375174&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866133	404344220							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746522	C[C@H](Nc1cccc(n1)N1CCCS1(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H19ClN4O3S/c1-12(15-11-13-10-14(20)6-7-16(13)22-19(15)25)21-17-4-2-5-18(23-17)24-8-3-9-28(24,26)27/h2,4-7,10-12H,3,8-9H2,1H3,(H,21,23)(H,22,25)	XMAKYSWHJIORTI-UHFFFAOYSA-N	375175	2-(6-{[(1S)-1-(6-chloro-2-::US10253015, Compound I-35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375175	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375175&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866134	404344221							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746523	C[C@H](Nc1nccc(NCCO)c1F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H18ClFN4O2/c1-10(23-17-16(20)15(4-5-22-17)21-6-7-25)13-9-11-8-12(19)2-3-14(11)24-18(13)26/h2-5,8-10,25H,6-7H2,1H3,(H,24,26)(H2,21,22,23)	PREVMHPABPEPEQ-UHFFFAOYSA-N	375176	6-chloro-3-[(1S)-1-({3-::US10253015, Compound I-36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375176	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375176&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866135	404344222							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746525	C[C@H](Nc1nccc(c1F)-n1ccnc1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H15ClFN5O/c1-11(14-9-12-8-13(20)2-3-15(12)25-19(14)27)24-18-17(21)16(4-5-23-18)26-7-6-22-10-26/h2-11H,1H3,(H,23,24)(H,25,27)	ICPLKKURITZNRW-UHFFFAOYSA-N	375177	6-chloro-3-[(1S)-1-{[3-::US10253015, Compound I-37	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375177	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375177&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866136	404344223							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746526	C[C@H](Nc1nccc(c1F)-n1cnc(C)c1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H17ClFN5O/c1-11-9-27(10-24-11)17-5-6-23-19(18(17)22)25-12(2)15-8-13-7-14(21)3-4-16(13)26-20(15)28/h3-10,12H,1-2H3,(H,23,25)(H,26,28)	SZWYKBOSXYLMCG-UHFFFAOYSA-N	375178	6-chloro-3-[(1S)-1-{[3-::US10253015, Compound I-38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375178	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375178&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866137	404344224							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746527	C[C@H](Nc1cc(ccn1)-c1cc(C)nn1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H20ClN5O/c1-12-8-19(27(3)26-12)14-6-7-23-20(11-14)24-13(2)17-10-15-9-16(22)4-5-18(15)25-21(17)28/h4-11,13H,1-3H3,(H,23,24)(H,25,28)	UVJTWKGPNRAHNW-UHFFFAOYSA-N	375179	6-chloro-3-[(1S)-1-{[4-(1,3-dimethyl-1H-::US10253015, Compound I-39	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375179	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375179&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866138	404344225							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746529	C[C@H](Nc1cc(ccn1)-c1cnn(C)c1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H20ClN5O/c1-12(17-9-15-8-16(22)4-5-19(15)26-21(17)28)25-20-10-14(6-7-23-20)18-11-24-27(3)13(18)2/h4-12H,1-3H3,(H,23,25)(H,26,28)	SPUFCDSCJOZNBH-UHFFFAOYSA-N	375180	6-chloro-3-[(1S)-1-{[4-(1,5-dimethyl-1H-::US10253015, Compound I-40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375180	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375180&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866139	404344226							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746531	C[C@H](Nc1cc(ccn1)-c1cnn(C)c1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H20ClN5O/c1-12(17-9-15-8-16(22)4-5-19(15)26-21(17)28)25-20-10-14(6-7-23-20)18-11-24-27(3)13(18)2/h4-12H,1-3H3,(H,23,25)(H,26,28)	SPUFCDSCJOZNBH-UHFFFAOYSA-N	375180	6-chloro-3-[(1S)-1-{[4-(1,5-dimethyl-1H-::US10253015, Compound I-40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375180	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375180&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866139	404344226							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746533	C[C@H](Nc1cc(ccn1)-c1ccn[nH]1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H16ClN5O/c1-11(15-9-13-8-14(20)2-3-16(13)24-19(15)26)23-18-10-12(4-6-21-18)17-5-7-22-25-17/h2-11H,1H3,(H,21,23)(H,22,25)(H,24,26)	ILLYIVJHFCMEDX-UHFFFAOYSA-N	375181	6-chloro-3-[(1S)-1-{[4-(1H-pyrazol-5-yl)pyridin-::US10253015, Compound I-41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375181	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375181&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866140	404344227							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746535	C[C@H](Nc1nccc(-c2cccn2C)c1F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H18ClFN4O/c1-12(16-11-13-10-14(22)5-6-17(13)26-21(16)28)25-20-19(23)15(7-8-24-20)18-4-3-9-27(18)2/h3-12H,1-2H3,(H,24,25)(H,26,28)	MAEFNOVVAVINNN-UHFFFAOYSA-N	375182	6-chloro-3-[(1S)-1-{[3-fluoro-4-(1-methyl-1H-::US10253015, Compound I-42	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375182	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375182&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866141	404344228							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746536	CC(C)Cn1nccc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)c1 |r|	InChI=1S/C23H24ClN5O/c1-14(2)13-29-21(7-9-26-29)16-6-8-25-22(12-16)27-15(3)19-11-17-10-18(24)4-5-20(17)28-23(19)30/h4-12,14-15H,13H2,1-3H3,(H,25,27)(H,28,30)	WWWFRQPTFRLINL-UHFFFAOYSA-N	375183	6-chloro-3-[(1S)-1-({4-[1-(2-methylpropyl)-1H-::US10253015, Compound I-43	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375183	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375183&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866142	404344229							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746538	CC(C)n1nccc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)c1 |r|	InChI=1S/C22H22ClN5O/c1-13(2)28-20(7-9-25-28)15-6-8-24-21(12-15)26-14(3)18-11-16-10-17(23)4-5-19(16)27-22(18)29/h4-14H,1-3H3,(H,24,26)(H,27,29)	ORSPJAPRETYQAL-UHFFFAOYSA-N	375184	6-chloro-3-[(1S)-1-({4-[1-(propan-2-yl)-1H-::US10253015, Compound I-44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375184	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375184&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866143	404344230							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746540	C[C@H](Nc1nccc(-c2cnn(C)c2C)c1F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H19ClFN5O/c1-11(16-9-13-8-14(22)4-5-18(13)27-21(16)29)26-20-19(23)15(6-7-24-20)17-10-25-28(3)12(17)2/h4-11H,1-3H3,(H,24,26)(H,27,29)	XAXWOYWHXUBGSB-UHFFFAOYSA-N	375185	6-chloro-3-[(1S)-1-{[4-(1,5-dimethyl-1H-::US10253015, Compound I-45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375185	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375185&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866144	404344231							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746541	C[C@H](Nc1nccc(-c2cscc2C)c1F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H17ClFN3OS/c1-11-9-28-10-17(11)15-5-6-24-20(19(15)23)25-12(2)16-8-13-7-14(22)3-4-18(13)26-21(16)27/h3-10,12H,1-2H3,(H,24,25)(H,26,27)	CGZMPANZZOOGFH-UHFFFAOYSA-N	375186	6-chloro-3-[(1S)-1-{[3-fluoro-4-(4-::US10253015, Compound I-46	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375186	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375186&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866145	404344232							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746542	C[C@H](Nc1cc(ccn1)-c1ccnn1C1CCCCO1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C24H24ClN5O2/c1-15(19-13-17-12-18(25)5-6-20(17)29-24(19)31)28-22-14-16(7-9-26-22)21-8-10-27-30(21)23-4-2-3-11-32-23/h5-10,12-15,23H,2-4,11H2,1H3,(H,26,28)(H,29,31)	ROBMPVUHFWUUAF-UHFFFAOYSA-N	375187	6-chloro-3-[(1S)-1-({4-[1-(oxan-2-yl)-1H-::US10253015, Compound I-47	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375187	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375187&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866146	404344233							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746544	C[C@H](Nc1cc(ccn1)-c1cscc1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H18ClN3OS/c1-12-10-27-11-18(12)14-5-6-23-20(9-14)24-13(2)17-8-15-7-16(22)3-4-19(15)25-21(17)26/h3-11,13H,1-2H3,(H,23,24)(H,25,26)	IPMCQKIUANVIHL-UHFFFAOYSA-N	375188	6-chloro-3-[(1S)-1-{[4-(4-methylthiophen-3-::US10253015, Compound I-48	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375188	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375188&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866147	404344234							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746546	C[C@H](Nc1cc(ccn1)-c1ccnn1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H18ClN5O/c1-12(16-10-14-9-15(21)3-4-17(14)25-20(16)27)24-19-11-13(5-7-22-19)18-6-8-23-26(18)2/h3-12H,1-2H3,(H,22,24)(H,25,27)	TVBIEZPKQZLNHR-UHFFFAOYSA-N	375189	6-chloro-3-[(1S)-1-{[4-(1-methyl-1H-pyrazol-5-::US10253015, Compound I-49	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375189	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375189&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866148	404344235							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746548	C[C@H](Nc1cc(ccn1)-c1c[nH]nc1C(F)(F)F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H15ClF3N5O/c1-10(14-7-12-6-13(21)2-3-16(12)28-19(14)30)27-17-8-11(4-5-25-17)15-9-26-29-18(15)20(22,23)24/h2-10H,1H3,(H,25,27)(H,26,29)(H,28,30)	JQJSWPLSMHFOCE-UHFFFAOYSA-N	375190	6-chloro-3-[(1S)-1-({4-[3-(trifluoromethyl)-1H-::US10253015, Compound I-50	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375190	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375190&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866149	404344236							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746550	C[C@H](Nc1nccc(-c2c(C)n[nH]c2C)c1F)c1cc2cc(Cl)ccc2[nH]c1=O |r,wD:1.0,(-.52,1.93,;-.52,.38,;.82,-.38,;2.15,.38,;2.15,1.93,;3.48,2.69,;4.82,1.93,;4.82,.38,;6.15,-.38,;7.61,.09,;8.38,1.42,;8.52,-1.15,;7.61,-2.4,;6.15,-1.93,;4.82,-2.69,;3.48,-.38,;3.48,-1.93,;-1.85,-.38,;-3.19,.38,;-4.52,-.38,;-5.85,.38,;-7.19,-.38,;-8.52,.38,;-7.19,-1.93,;-5.85,-2.69,;-4.52,-1.93,;-3.19,-2.69,;-1.85,-1.93,;-.52,-2.69,)|	InChI=1S/C21H19ClFN5O/c1-10(16-9-13-8-14(22)4-5-17(13)26-21(16)29)25-20-19(23)15(6-7-24-20)18-11(2)27-28-12(18)3/h4-10H,1-3H3,(H,24,25)(H,26,29)(H,27,28)	CUKCVXGNLKIIRL-UHFFFAOYSA-N	375191	6-chloro-3-[(1S)-1-{[4-(3,5-dimethyl-1H-::US10253015, Compound I-51	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375191	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375191&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866150	404344237							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746551	C[C@H](Nc1nccc(-c2cc(C)nn2C)c1F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H19ClFN5O/c1-11-8-18(28(3)27-11)15-6-7-24-20(19(15)23)25-12(2)16-10-13-9-14(22)4-5-17(13)26-21(16)29/h4-10,12H,1-3H3,(H,24,25)(H,26,29)	VNYLNCVIABLMDR-UHFFFAOYSA-N	375192	6-chloro-3-[(1S)-1-{[4-(1,3-dimethyl-1H-::US10253015, Compound I-52	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375192	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375192&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866151	404344238							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746553	C[C@H](Nc1nccc(-c2ccnn2C)c1F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H17ClFN5O/c1-11(15-10-12-9-13(21)3-4-16(12)26-20(15)28)25-19-18(22)14(5-7-23-19)17-6-8-24-27(17)2/h3-11H,1-2H3,(H,23,25)(H,26,28)	UYGTXGQZGGESCZ-UHFFFAOYSA-N	375193	6-chloro-3-[(1S)-1-{[3-fluoro-4-(1-methyl-1H-::US10253015, Compound I-53	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375193	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375193&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866152	404344239							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746555	C[C@H](Nc1nccc(-c2c(C)noc2C)c1F)c1cc2cc(Cl)ccc2[nH]c1=O |r,wD:1.0,(-.52,1.93,;-.52,.38,;.82,-.38,;2.15,.38,;2.15,1.93,;3.48,2.69,;4.82,1.93,;4.82,.38,;6.15,-.38,;7.61,.09,;8.38,1.42,;8.52,-1.15,;7.61,-2.4,;6.15,-1.93,;4.82,-2.69,;3.48,-.38,;3.48,-1.93,;-1.85,-.38,;-3.19,.38,;-4.52,-.38,;-5.85,.38,;-7.19,-.38,;-8.52,.38,;-7.19,-1.93,;-5.85,-2.69,;-4.52,-1.93,;-3.19,-2.69,;-1.85,-1.93,;-.52,-2.69,)|	InChI=1S/C21H18ClFN4O2/c1-10(16-9-13-8-14(22)4-5-17(13)26-21(16)28)25-20-19(23)15(6-7-24-20)18-11(2)27-29-12(18)3/h4-10H,1-3H3,(H,24,25)(H,26,28)	CPBACATZAFMUGL-UHFFFAOYSA-N	375194	6-chloro-3-[(1S)-1-{[4-(dimethyl-1,2-oxazol-4-::US10253015, Compound I-54	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375194	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375194&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866153	404344240							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746556	C[C@H](Nc1nccc(-c2ccnn2C2CCCCO2)c1F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C24H23ClFN5O2/c1-14(18-13-15-12-16(25)5-6-19(15)30-24(18)32)29-23-22(26)17(7-9-27-23)20-8-10-28-31(20)21-4-2-3-11-33-21/h5-10,12-14,21H,2-4,11H2,1H3,(H,27,29)(H,30,32)	AQLOFOVQGFDRPG-UHFFFAOYSA-N	375195	6-chloro-3-[(1S)-1-({3-fluoro-4-[1-(oxan-2-yl)-::US10253015, Compound I-55	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375195	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375195&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866154	404344241							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746557	CC(C)Cn1nccc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)c1F |r|	InChI=1S/C23H23ClFN5O/c1-13(2)12-30-20(7-9-27-30)17-6-8-26-22(21(17)25)28-14(3)18-11-15-10-16(24)4-5-19(15)29-23(18)31/h4-11,13-14H,12H2,1-3H3,(H,26,28)(H,29,31)	SUBHERSBVVYQIF-UHFFFAOYSA-N	375196	6-chloro-3-[(1S)-1-({3-fluoro-4-[1-(2-::US10253015, Compound I-56	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375196	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375196&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866155	404344242							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746559	CC(C)n1nccc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)c1F |r|	InChI=1S/C22H21ClFN5O/c1-12(2)29-19(7-9-26-29)16-6-8-25-21(20(16)24)27-13(3)17-11-14-10-15(23)4-5-18(14)28-22(17)30/h4-13H,1-3H3,(H,25,27)(H,28,30)	FHPRCVOIQSJNBT-UHFFFAOYSA-N	375197	6-chloro-3-[(1S)-1-({3-fluoro-4-[1-(propan-2-yl)-::US10253015, Compound I-57	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375197	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375197&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866156	404344243							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746560	Cc1c(ccc(n1)NCC2=Cc3cc(ccc3NC2=O)Cl)C#N	InChI=1S/C17H13ClN4O/c1-10-11(8-19)2-5-16(21-10)20-9-13-6-12-7-14(18)3-4-15(12)22-17(13)23/h2-7H,9H2,1H3,(H,20,21)(H,22,23)	BPIFALCAPCGTGS-UHFFFAOYSA-N	375198	6-{[(6-chloro-2-oxo-1,2-::US10253015, Compound I-58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375198	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375198&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	LJV	6O2Z	145866157	404344244							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746562	Cc1c(ccc(n1)NCC2=Cc3cc(ccc3NC2=O)Cl)C#N	InChI=1S/C17H13ClN4O/c1-10-11(8-19)2-5-16(21-10)20-9-13-6-12-7-14(18)3-4-15(12)22-17(13)23/h2-7H,9H2,1H3,(H,20,21)(H,22,23)	BPIFALCAPCGTGS-UHFFFAOYSA-N	375198	6-{[(6-chloro-2-oxo-1,2-::US10253015, Compound I-58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375198	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375198&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	LJV	6O2Z	145866157	404344244							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746564	Cc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ncc1C#N	InChI=1S/C17H13ClN4O/c1-10-4-16(21-9-13(10)7-19)20-8-12-5-11-6-14(18)2-3-15(11)22-17(12)23/h2-6,9H,8H2,1H3,(H,20,21)(H,22,23)	LXMKACJDWYHEEG-UHFFFAOYSA-N	375199	6-{[(6-chloro-2-oxo-1,2-::US10253015, Compound I-59	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375199	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375199&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866158	404344245							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746566	FC(F)(F)c1nc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C17H10ClF3N4O/c18-12-2-3-13-10(6-12)5-11(16(26)24-13)8-23-14-4-1-9(7-22)15(25-14)17(19,20)21/h1-6H,8H2,(H,23,25)(H,24,26)	UPRVUPAVFSQSTR-UHFFFAOYSA-N	375200	6-{[(6-chloro-2-oxo-1,2-::US10253015, Compound I-60	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375200	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375200&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866159	404344246							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746567	COc1nc(ccc1NCc1cc2cc(Cl)ccc2[nH]c1=O)C#N	InChI=1S/C17H13ClN4O2/c1-24-17-15(5-3-13(8-19)21-17)20-9-11-6-10-7-12(18)2-4-14(10)22-16(11)23/h2-7,20H,9H2,1H3,(H,22,23)	JDBYZAQUMPABHV-UHFFFAOYSA-N	375201	5-{[(6-chloro-2-oxo-1,2-::US10253015, Compound I-61	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375201	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375201&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866160	404344247							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746568	Clc1ccc2[nH]c(=O)c(CNc3ccc(C#N)c(Cl)n3)cc2c1	InChI=1S/C16H10Cl2N4O/c17-12-2-3-13-10(6-12)5-11(16(23)21-13)8-20-14-4-1-9(7-19)15(18)22-14/h1-6H,8H2,(H,20,22)(H,21,23)	RAWUYPHHNCIVPK-UHFFFAOYSA-N	375202	2-chloro-6-{[(6-chloro-2-::US10253015, Compound I-62	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375202	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375202&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866161	404344248							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746569	Clc1ccc2[nH]c(=O)c(CNc3ccc(C#N)c(n3)N3CCOC3=O)cc2c1	InChI=1S/C19H14ClN5O3/c20-14-2-3-15-12(8-14)7-13(18(26)23-15)10-22-16-4-1-11(9-21)17(24-16)25-5-6-28-19(25)27/h1-4,7-8H,5-6,10H2,(H,22,24)(H,23,26)	XWYNNCZCGSUBAG-UHFFFAOYSA-N	375203	6-{[(6-chloro-2-oxo-1,2-::US10253015, Compound I-63	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375203	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375203&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866162	404344249							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746570	CC(C)C1CCCN1c1nc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C23H24ClN5O/c1-14(2)20-4-3-9-29(20)22-15(12-25)5-8-21(28-22)26-13-17-10-16-11-18(24)6-7-19(16)27-23(17)30/h5-8,10-11,14,20H,3-4,9,13H2,1-2H3,(H,26,28)(H,27,30)	XMGLPDJMVGDMBR-UHFFFAOYSA-N	375204	6-{[(6-chloro-2-oxo-1,2-::US10253015, Compound I-64	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375204	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375204&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866163	404344250							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746571	CC(C)CN(C)c1nc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C21H22ClN5O/c1-13(2)12-27(3)20-14(10-23)4-7-19(26-20)24-11-16-8-15-9-17(22)5-6-18(15)25-21(16)28/h4-9,13H,11-12H2,1-3H3,(H,24,26)(H,25,28)	TYJNSFZDRJRYLI-UHFFFAOYSA-N	375205	6-{[(6-chloro-2-oxo-1,2-::US10253015, Compound I-65	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375205	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375205&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866164	404344251							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746572	COc1nc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C17H13ClN4O2/c1-24-17-10(8-19)2-5-15(22-17)20-9-12-6-11-7-13(18)3-4-14(11)21-16(12)23/h2-7H,9H2,1H3,(H,20,22)(H,21,23)	AFFQZAUKAFCUFK-UHFFFAOYSA-N	375206	6-{[(6-chloro-2-oxo-1,2-::US10253015, Compound I-66	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375206	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375206&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866165	404344252							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746573	Clc1ccc2[nH]c(=O)c(CNc3ccc(cn3)C#N)cc2c1	InChI=1S/C16H11ClN4O/c17-13-2-3-14-11(6-13)5-12(16(22)21-14)9-20-15-4-1-10(7-18)8-19-15/h1-6,8H,9H2,(H,19,20)(H,21,22)	GWBZGQRLLUJXRH-UHFFFAOYSA-N	375207	6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-::US10253015, Compound I-67	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375207	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375207&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866166	404344253							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746575	CC(C)c1cccnc1NCc1cc2cc(Cl)ccc2[nH]c1=O	InChI=1S/C18H18ClN3O/c1-11(2)15-4-3-7-20-17(15)21-10-13-8-12-9-14(19)5-6-16(12)22-18(13)23/h3-9,11H,10H2,1-2H3,(H,20,21)(H,22,23)	VJNQGTJKUQKLAM-UHFFFAOYSA-N	375208	6-chloro-3-({[3-(propan-2-yl)pyridin-2-::US10253015, Compound I-68	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375208	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375208&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866167	404344254							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746576	Cc1cc(C)nc(NCc2cc3cc(Cl)ccc3[nH]c2=O)c1	InChI=1S/C17H16ClN3O/c1-10-5-11(2)20-16(6-10)19-9-13-7-12-8-14(18)3-4-15(12)21-17(13)22/h3-8H,9H2,1-2H3,(H,19,20)(H,21,22)	MBXZAQKOYFGMSZ-UHFFFAOYSA-N	375209	6-chloro-3-{[(4,6-dimethylpyridin-2-::US10253015, Compound I-69	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375209	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375209&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866168	404344255							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746577	COc1ccnc(NCc2cc3cc(Cl)ccc3[nH]c2=O)c1	InChI=1S/C16H14ClN3O2/c1-22-13-4-5-18-15(8-13)19-9-11-6-10-7-12(17)2-3-14(10)20-16(11)21/h2-8H,9H2,1H3,(H,18,19)(H,20,21)	VNJKIUJTLMAMNW-UHFFFAOYSA-N	375210	6-chloro-3-{[(4-methoxypyridin-2-::US10253015, Compound I-70	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375210	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375210&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866169	404344256							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746578	Fc1ccc(NCc2cc3cc(Cl)ccc3[nH]c2=O)nc1	InChI=1S/C15H11ClFN3O/c16-11-1-3-13-9(6-11)5-10(15(21)20-13)7-18-14-4-2-12(17)8-19-14/h1-6,8H,7H2,(H,18,19)(H,20,21)	HAGZERHIFUABLK-UHFFFAOYSA-N	375211	6-chloro-3-{[(5-fluoropyridin-2-::US10253015, Compound I-71	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375211	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375211&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866170	404344257							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746579	Clc1ccc2[nH]c(=O)c(CNc3cc(ccn3)C#N)cc2c1	InChI=1S/C16H11ClN4O/c17-13-1-2-14-11(7-13)6-12(16(22)21-14)9-20-15-5-10(8-18)3-4-19-15/h1-7H,9H2,(H,19,20)(H,21,22)	QCEYHSNACRIWMH-UHFFFAOYSA-N	375212	2-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-::US10253015, Compound I-72	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375212	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375212&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866171	404344258							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746580	COC(=O)c1cccc(NCc2cc3cc(Cl)ccc3[nH]c2=O)n1	InChI=1S/C17H14ClN3O3/c1-24-17(23)14-3-2-4-15(20-14)19-9-11-7-10-8-12(18)5-6-13(10)21-16(11)22/h2-8H,9H2,1H3,(H,19,20)(H,21,22)	WKDOBLADLFRNBO-UHFFFAOYSA-N	375213	methyl 6-{[(6-chloro-2-oxo-1,2-::US10253015, Compound I-73	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375213	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375213&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866172	404344259							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746581	Cc1ccnc(NCc2cc3cc(Cl)ccc3[nH]c2=O)c1	InChI=1S/C16H14ClN3O/c1-10-4-5-18-15(6-10)19-9-12-7-11-8-13(17)2-3-14(11)20-16(12)21/h2-8H,9H2,1H3,(H,18,19)(H,20,21)	CBFXKVFGFBFFOJ-UHFFFAOYSA-N	375214	6-chloro-3-{[(4-methylpyridin-2-::US10253015, Compound I-74	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375214	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375214&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866173	404344260							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746582	Clc1ccc(NCc2cc3cc(Cl)ccc3[nH]c2=O)nc1	InChI=1S/C15H11Cl2N3O/c16-11-1-3-13-9(6-11)5-10(15(21)20-13)7-18-14-4-2-12(17)8-19-14/h1-6,8H,7H2,(H,18,19)(H,20,21)	CTGOZBADLYFXRY-UHFFFAOYSA-N	375215	6-chloro-3-{[(5-chloropyridin-2-::US10253015, Compound I-75	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375215	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375215&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866174	404344261							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746583	Oc1ncccc1NCc1cc2cc(Cl)ccc2[nH]c1=O	InChI=1S/C15H12ClN3O2/c16-11-3-4-12-9(7-11)6-10(14(20)19-12)8-18-13-2-1-5-17-15(13)21/h1-7,18H,8H2,(H,17,21)(H,19,20)	TWNBYBXSTICTLX-UHFFFAOYSA-N	375216	6-chloro-3-{[(2-hydroxypyridin-3-::US10253015, Compound I-76	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375216	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375216&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866175	404344262							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746584	FC(F)(F)c1ccc(NCc2cc3cc(Cl)ccc3[nH]c2=O)nc1	InChI=1S/C16H11ClF3N3O/c17-12-2-3-13-9(6-12)5-10(15(24)23-13)7-21-14-4-1-11(8-22-14)16(18,19)20/h1-6,8H,7H2,(H,21,22)(H,23,24)	ZSQDYNDVXKISEJ-UHFFFAOYSA-N	375217	6-chloro-3-({[5-(trifluoromethyl)pyridin-2-::US10253015, Compound I-77	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375217	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375217&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866176	404344263							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746585	Clc1ccc2[nH]c(=O)c(CNc3ccc(nc3)C#N)cc2c1	InChI=1S/C16H11ClN4O/c17-12-1-4-15-10(6-12)5-11(16(22)21-15)8-19-14-3-2-13(7-18)20-9-14/h1-6,9,19H,8H2,(H,21,22)	WGKDYBHVCHZYSW-UHFFFAOYSA-N	375218	5-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-::US10253015, Compound I-78	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375218	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375218&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866177	404344264							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746586	FC(F)(F)c1ccnc(NCc2cc3cc(Cl)ccc3[nH]c2=O)c1	InChI=1S/C16H11ClF3N3O/c17-12-1-2-13-9(6-12)5-10(15(24)23-13)8-22-14-7-11(3-4-21-14)16(18,19)20/h1-7H,8H2,(H,21,22)(H,23,24)	NTSUBYOORCDTBW-UHFFFAOYSA-N	375219	6-chloro-3-({[4-(trifluoromethyl)pyridin-2-::US10253015, Compound I-79	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375219	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375219&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866178	404344265							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746587	Cc1cc2cc(CNc3ccc(cn3)C#N)c(=O)[nH]c2cc1C	InChI=1S/C18H16N4O/c1-11-5-14-7-15(18(23)22-16(14)6-12(11)2)10-21-17-4-3-13(8-19)9-20-17/h3-7,9H,10H2,1-2H3,(H,20,21)(H,22,23)	RGKGVXOGRUPRSU-UHFFFAOYSA-N	375220	6-{[(6,7-dimethyl-2-oxo-1,2-dihydroquinolin-::US10253015, Compound I-80	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375220	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375220&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866179	404344266							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746588	COc1ccc2[nH]c(=O)c(CNc3ccc(cn3)C#N)cc2c1	InChI=1S/C17H14N4O2/c1-23-14-3-4-15-12(7-14)6-13(17(22)21-15)10-20-16-5-2-11(8-18)9-19-16/h2-7,9H,10H2,1H3,(H,19,20)(H,21,22)	VVWRUKYUZPANQP-UHFFFAOYSA-N	375221	6-{[(6-methoxy-2-oxo-1,2-dihydroquinolin-3-::US10253015, Compound I-81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375221	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375221&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866180	404344267							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746589	COc1ccc2[nH]c(=O)c(CNc3cc(C)ccn3)cc2c1	InChI=1S/C17H17N3O2/c1-11-5-6-18-16(7-11)19-10-13-8-12-9-14(22-2)3-4-15(12)20-17(13)21/h3-9H,10H2,1-2H3,(H,18,19)(H,20,21)	XVEITJMIOOETAB-UHFFFAOYSA-N	375222	6-methoxy-3-{[(4-methylpyridin-2-::US10253015, Compound I-82	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375222	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375222&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866181	404344268							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746590	COc1cc2[nH]c(=O)c(CNc3ccc(C#N)c(C)n3)cc2cc1Cl	InChI=1S/C18H15ClN4O2/c1-10-11(8-20)3-4-17(22-10)21-9-13-5-12-6-14(19)16(25-2)7-15(12)23-18(13)24/h3-7H,9H2,1-2H3,(H,21,22)(H,23,24)	JKVBPFJAMHQRCZ-UHFFFAOYSA-N	375223	6-{[(6-chloro-7-methoxy-2-oxo-1,2-::US10253015, Compound I-83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375223	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375223&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866182	404344269							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746592	COc1cc2[nH]c(=O)c(CNc3ccc(C#N)c(C)n3)cc2cc1Cl	InChI=1S/C18H15ClN4O2/c1-10-11(8-20)3-4-17(22-10)21-9-13-5-12-6-14(19)16(25-2)7-15(12)23-18(13)24/h3-7H,9H2,1-2H3,(H,21,22)(H,23,24)	JKVBPFJAMHQRCZ-UHFFFAOYSA-N	375223	6-{[(6-chloro-7-methoxy-2-oxo-1,2-::US10253015, Compound I-83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q23F4S02		aid1798275	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375223	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375223&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866182	404344269							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746594	Cc1nc(NCc2cc3cc(Cl)c(OCc4ccccn4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C23H18ClN5O2/c1-14-15(11-25)5-6-22(28-14)27-12-17-8-16-9-19(24)21(10-20(16)29-23(17)30)31-13-18-4-2-3-7-26-18/h2-10H,12-13H2,1H3,(H,27,28)(H,29,30)	GDWCDQTWQBNEFB-UHFFFAOYSA-N	375224	6-({[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-::US10253015, Compound I-84	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375224	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375224&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866183	404344270							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
746595	Cc1nc(NCc2cc3cc(Cl)c(OCCN4CCN(CC4)S(C)(=O)=O)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H27ClN6O4S/c1-16-17(14-26)3-4-23(28-16)27-15-19-11-18-12-20(25)22(13-21(18)29-24(19)32)35-10-9-30-5-7-31(8-6-30)36(2,33)34/h3-4,11-13H,5-10,15H2,1-2H3,(H,27,28)(H,29,32)	PKIRZPJXKJUCFZ-UHFFFAOYSA-N	375225	6-[({6-chloro-7-[2-(4-::US10253015, Compound I-85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q23F4S02		aid1798274	US10253015	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	4/9/2019	1/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375225	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375225&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866184	404344271							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755296	COc1cc(NC(C)c2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C19H16ClN3O2/c1-11(22-15-5-3-12(10-21)18(9-15)25-2)16-8-13-7-14(20)4-6-17(13)23-19(16)24/h3-9,11,22H,1-2H3,(H,23,24)	POQQQCAOZAXQHW-UHFFFAOYSA-N	377521	US10266495, Compound I-1::4-{[1-(6-chloro-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377521&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866737	404346489							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755298	COc1cc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N |r|	InChI=1S/C19H16ClN3O2/c1-11(22-15-5-3-12(10-21)18(9-15)25-2)16-8-13-7-14(20)4-6-17(13)23-19(16)24/h3-9,11,22H,1-2H3,(H,23,24)	POQQQCAOZAXQHW-UHFFFAOYSA-N	377574	US10266495, Compound I-2::4-{[(1S)-1-(6-chloro-2-oxo-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377574&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866738	404346541							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755300	COc1cc(N[C@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N |r|	InChI=1S/C19H16ClN3O2/c1-11(22-15-5-3-12(10-21)18(9-15)25-2)16-8-13-7-14(20)4-6-17(13)23-19(16)24/h3-9,11,22H,1-2H3,(H,23,24)	POQQQCAOZAXQHW-UHFFFAOYSA-N	377591	US10266495, Compound I-3::4-{[(1R)-1-(6-chloro-2-oxo-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377591&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866739	404346558							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755301	CS(=O)(=O)c1cc(ccc1NCc1cc2cc(Cl)ccc2[nH]c1=O)C#N	InChI=1S/C18H14ClN3O3S/c1-26(24,25)17-6-11(9-20)2-4-16(17)21-10-13-7-12-8-14(19)3-5-15(12)22-18(13)23/h2-8,21H,10H2,1H3,(H,22,23)	DAMMQCSIHDORSR-UHFFFAOYSA-N	377592	US10266495, Compound I-4::4-{[(1S)-1-(6-chloro-2-oxo-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377592&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866740	404346559							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755302	COc1cc(NC(C)c2cc3cc(Cl)c(OCc4ccccn4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H21ClN4O3/c1-15(29-18-7-6-16(13-27)23(11-18)32-2)20-9-17-10-21(26)24(12-22(17)30-25(20)31)33-14-19-5-3-4-8-28-19/h3-12,15,29H,14H2,1-2H3,(H,30,31)	ORMQJKSZDSYQNK-UHFFFAOYSA-N	377593	US10266495, Compound I-5::4-({1-[6-chloro-2-oxo-7-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377593&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866741	404346560							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755304	COc1cc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ccc1S(C)(=O)=O |r|	InChI=1S/C19H19ClN2O4S/c1-11(15-9-12-8-13(20)4-6-16(12)22-19(15)23)21-14-5-7-18(27(3,24)25)17(10-14)26-2/h4-11,21H,1-3H3,(H,22,23)	CTBJXBDWZXFERM-UHFFFAOYSA-N	377594	US10266495, Compound I-6::6-chloro-3-[(1S)-1-[(4-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377594&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866742	404346561							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755305	COc1cc(ccc1C#N)NCC2=Cc3cc(ccc3NC2=O)Cl	InChI=1S/C18H14ClN3O2/c1-24-17-8-15(4-2-11(17)9-20)21-10-13-6-12-7-14(19)3-5-16(12)22-18(13)23/h2-8,21H,10H2,1H3,(H,22,23)	DHTDEOJRSYUVPD-UHFFFAOYSA-N	377595	US10266495, Compound I-7::4-{[(6-chloro-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377595&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	LJY	6O2Y	145866743	404346562							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755307	Oc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C17H12ClN3O2/c18-13-2-4-15-11(6-13)5-12(17(23)21-15)9-20-14-3-1-10(8-19)16(22)7-14/h1-7,20,22H,9H2,(H,21,23)	VDYPXURCTYLBFX-UHFFFAOYSA-N	377596	US10266495, Compound I-8::4-{[(6-chloro-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377596&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866744	404346563							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755309	COc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)cc(OC)c1C#N	InChI=1S/C19H16ClN3O3/c1-25-17-7-14(8-18(26-2)15(17)9-21)22-10-12-5-11-6-13(20)3-4-16(11)23-19(12)24/h3-8,22H,10H2,1-2H3,(H,23,24)	QMMJQMZFINBAFK-UHFFFAOYSA-N	377597	US10266495, Compound I-9::4-{[(6-chloro-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377597&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866745	404346564							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755311	FC(F)(F)Oc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C18H11ClF3N3O2/c19-13-2-4-15-11(6-13)5-12(17(26)25-15)9-24-14-3-1-10(8-23)16(7-14)27-18(20,21)22/h1-7,24H,9H2,(H,25,26)	AGNDYSBKXMQKIB-UHFFFAOYSA-N	377598	US10266495, Compound I-10::4-{[(6-chloro-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377598&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866746	404346565							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755313	OCCOc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C19H16ClN3O3/c20-15-2-4-17-13(8-15)7-14(19(25)23-17)11-22-16-3-1-12(10-21)18(9-16)26-6-5-24/h1-4,7-9,22,24H,5-6,11H2,(H,23,25)	KWKSRBWGRBSOON-UHFFFAOYSA-N	377599	US10266495, Compound I-11::4-{[(6-chloro-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377599&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866747	404346566							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755314	COc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1-n1ccnc1	InChI=1S/C20H17ClN4O2/c1-27-19-10-16(3-5-18(19)25-7-6-22-12-25)23-11-14-8-13-9-15(21)2-4-17(13)24-20(14)26/h2-10,12,23H,11H2,1H3,(H,24,26)	MBRVVNSUDOORFE-UHFFFAOYSA-N	377600	US10266495, Compound I-12::6-chloro-3-({[4-(1H-imidazol-1-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377600&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866748	404346567							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755315	CCOc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C19H16ClN3O2/c1-2-25-18-9-16(5-3-12(18)10-21)22-11-14-7-13-8-15(20)4-6-17(13)23-19(14)24/h3-9,22H,2,11H2,1H3,(H,23,24)	RCJGFHDCHPKEJC-UHFFFAOYSA-N	377601	US10266495, Compound I-13::4-{[(6-chloro-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377601&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866749	404346568							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755316	NC(=O)COc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C19H15ClN4O3/c20-14-2-4-16-12(6-14)5-13(19(26)24-16)9-23-15-3-1-11(8-21)17(7-15)27-10-18(22)25/h1-7,23H,9-10H2,(H2,22,25)(H,24,26)	PTPMJQMSUFELGJ-UHFFFAOYSA-N	377602	US10266495, Compound I-14::2-(5-{[(6-chloro-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377602&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866750	404346569							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755317	COc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1S(C)(=O)=O	InChI=1S/C18H17ClN2O4S/c1-25-16-9-14(4-6-17(16)26(2,23)24)20-10-12-7-11-8-13(19)3-5-15(11)21-18(12)22/h3-9,20H,10H2,1-2H3,(H,21,22)	SHYVLODAAQLLMP-UHFFFAOYSA-N	377603	US10266495, Compound I-15::6-chloro-3-{[(4-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377603&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866751	404346570							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755318	COc1cc(NCc2cc3cc(C)ccc3[nH]c2=O)ccc1-n1cnnn1	InChI=1S/C19H18N6O2/c1-12-3-5-16-13(7-12)8-14(19(26)22-16)10-20-15-4-6-17(18(9-15)27-2)25-11-21-23-24-25/h3-9,11,20H,10H2,1-2H3,(H,22,26)	GGLPMVYVIFIYHC-UHFFFAOYSA-N	377604	US10266495, Compound I-16::3-({[3-methoxy-4-(1H-1,2,3,4-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377604&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			75260688	404346571							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755320	COc1cc(NCc2cc3cc(C)c(C)cc3[nH]c2=O)ccc1C#N	InChI=1S/C20H19N3O2/c1-12-6-15-8-16(20(24)23-18(15)7-13(12)2)11-22-17-5-4-14(10-21)19(9-17)25-3/h4-9,22H,11H2,1-3H3,(H,23,24)	RCZKEFJNYMXDCG-UHFFFAOYSA-N	377605	US10266495, Compound I-17::4-{[(6,7-dimethyl-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377605&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866752	404346572							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755321	COc1cc(NCc2cc3cc(C)ccc3[nH]c2=O)ccc1-n1cnc(C)c1	InChI=1S/C22H22N4O2/c1-14-4-6-19-16(8-14)9-17(22(27)25-19)11-23-18-5-7-20(21(10-18)28-3)26-12-15(2)24-13-26/h4-10,12-13,23H,11H2,1-3H3,(H,25,27)	ZBWRUQNJDLYOSH-UHFFFAOYSA-N	377606	US10266495, Compound I-18::3-({[3-methoxy-4-(4-methyl-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377606&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866753	404346573							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755322	Cc1cc2cc(CNc3cccc(c3)S(=O)(=O)NC3=NCCC3)c(=O)[nH]c2cc1C |t:19|	InChI=1S/C22H24N4O3S/c1-14-9-16-11-17(22(27)25-20(16)10-15(14)2)13-24-18-5-3-6-19(12-18)30(28,29)26-21-7-4-8-23-21/h3,5-6,9-12,24H,4,7-8,13H2,1-2H3,(H,23,26)(H,25,27)	MOBJWBBPDOHGNV-UHFFFAOYSA-N	377607	US10266495, Compound I-19::N-(3,4-dihydro-2H-pyrrol-5-yl)-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377607&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866754	404346574							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755323	COc1cc(NCc2cc3cc(C)c(C)cc3[nH]c2=O)ccc1-n1cnnn1	InChI=1S/C20H20N6O2/c1-12-6-14-8-15(20(27)23-17(14)7-13(12)2)10-21-16-4-5-18(19(9-16)28-3)26-11-22-24-25-26/h4-9,11,21H,10H2,1-3H3,(H,23,27)	LCHPNLBLXJZGQW-UHFFFAOYSA-N	377608	US10266495, Compound I-20::3-({[3-methoxy-4-(1H-1,2,3,4-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377608&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			75260387	404346575							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755324	COc1cc2[nH]c(=O)c(CNc3ccc(C#N)c(OC)c3)cc2cc1Cl	InChI=1S/C19H16ClN3O3/c1-25-17-7-14(4-3-11(17)9-21)22-10-13-5-12-6-15(20)18(26-2)8-16(12)23-19(13)24/h3-8,22H,10H2,1-2H3,(H,23,24)	LTDKQKQDKAKNGO-UHFFFAOYSA-N	377609	US10266495, Compound I-21::4-{[(6-chloro-7-methoxy-2-oxo-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377609&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866755	404346576							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755326	COc1cc(NCc2cc3ccc(C)cc3[nH]c2=O)ccc1-n1cnnn1	InChI=1S/C19H18N6O2/c1-12-3-4-13-8-14(19(26)22-16(13)7-12)10-20-15-5-6-17(18(9-15)27-2)25-11-21-23-24-25/h3-9,11,20H,10H2,1-2H3,(H,22,26)	BPKREDZWJFPBSA-UHFFFAOYSA-N	377610	US10266495, Compound I-22::3-({[3-methoxy-4-(1H-1,2,3,4-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377610&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866756	404346577							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755328	COc1cc(NCc2cc3cc(Br)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C18H14BrN3O2/c1-24-17-8-15(4-2-11(17)9-20)21-10-13-6-12-7-14(19)3-5-16(12)22-18(13)23/h2-8,21H,10H2,1H3,(H,22,23)	XDYKRRBDIPZTPK-UHFFFAOYSA-N	377611	US10266495, Compound I-23::4-{[(6-bromo-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377611	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377611&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866757	404346578							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755329	COc1cc(NCc2cc3cc(ccc3[nH]c2=O)C(C)(C)C)ccc1C#N	InChI=1S/C22H23N3O2/c1-22(2,3)17-6-8-19-15(10-17)9-16(21(26)25-19)13-24-18-7-5-14(12-23)20(11-18)27-4/h5-11,24H,13H2,1-4H3,(H,25,26)	OEDVWCKFJJKSQV-UHFFFAOYSA-N	377612	US10266495, Compound I-24::4-{[(6-tert-butyl-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377612&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866758	404346579							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755331	COc1cc(NCc2cc3cc(ccc3[nH]c2=O)C(F)(F)F)ccc1C#N	InChI=1S/C19H14F3N3O2/c1-27-17-8-15(4-2-11(17)9-23)24-10-13-6-12-7-14(19(20,21)22)3-5-16(12)25-18(13)26/h2-8,24H,10H2,1H3,(H,25,26)	FJTQXYUFLWOBDV-UHFFFAOYSA-N	377613	US10266495, Compound I-25::2-methoxy-4-({[2-oxo-6-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377613&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866759	404346580							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755333	COc1cc2[nH]c(=O)c(CNc3ccc(C#N)c(OC)c3)cc2cc1F	InChI=1S/C19H16FN3O3/c1-25-17-7-14(4-3-11(17)9-21)22-10-13-5-12-6-15(20)18(26-2)8-16(12)23-19(13)24/h3-8,22H,10H2,1-2H3,(H,23,24)	GPCTVBQLFMBFGO-UHFFFAOYSA-N	377614	US10266495, Compound I-26::4-{[(6-fluoro-7-methoxy-2-oxo-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377614&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866760	404346581							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755335	COc1cc(NCc2cc3cc(F)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C18H14FN3O2/c1-24-17-8-15(4-2-11(17)9-20)21-10-13-6-12-7-14(19)3-5-16(12)22-18(13)23/h2-8,21H,10H2,1H3,(H,22,23)	NKLSBGPINAONGO-UHFFFAOYSA-N	377615	US10266495, Compound I-27::4-{[(6-fluoro-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377615&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866761	404346582							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755337	COc1cc(NCc2cc3cc(I)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C18H14IN3O2/c1-24-17-8-15(4-2-11(17)9-20)21-10-13-6-12-7-14(19)3-5-16(12)22-18(13)23/h2-8,21H,10H2,1H3,(H,22,23)	CYVPAGBFZFANKZ-UHFFFAOYSA-N	377616	US10266495, Compound I-28::4-{[(6-iodo-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377616&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866762	404346583							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755338	COc1cc(NCc2cc3ccc(Cl)cc3[nH]c2=O)ccc1C#N	InChI=1S/C18H14ClN3O2/c1-24-17-8-15(5-3-12(17)9-20)21-10-13-6-11-2-4-14(19)7-16(11)22-18(13)23/h2-8,21H,10H2,1H3,(H,22,23)	TXZUSOMDIDEBSP-UHFFFAOYSA-N	377617	US10266495, Compound I-29::4-{[(7-chloro-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377617&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866763	404346584							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755339	COc1cc(NCc2cc3ccc(O)cc3[nH]c2=O)ccc1C#N	InChI=1S/C18H15N3O3/c1-24-17-7-14(4-2-12(17)9-19)20-10-13-6-11-3-5-15(22)8-16(11)21-18(13)23/h2-8,20,22H,10H2,1H3,(H,21,23)	GXCVGRIFRRAEIM-UHFFFAOYSA-N	377618	US10266495, Compound I-30::4-{[(7-hydroxy-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377618&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866764	404346585							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755341	COc1cc(NCc2cc3cccnc3[nH]c2=O)ccc1C#N	InChI=1S/C17H14N4O2/c1-23-15-8-14(5-4-12(15)9-18)20-10-13-7-11-3-2-6-19-16(11)21-17(13)22/h2-8,20H,10H2,1H3,(H,19,21,22)	DNSLELYZWQLSLN-UHFFFAOYSA-N	377619	US10266495, Compound I-31::2-methoxy-4-{[(2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377619&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866765	404346586							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755342	Clc1ccc2cc(CNc3ccc(cc3)C#N)c(=O)[nH]c2c1	InChI=1S/C17H12ClN3O/c18-14-4-3-12-7-13(17(22)21-16(12)8-14)10-20-15-5-1-11(9-19)2-6-15/h1-8,20H,10H2,(H,21,22)	RQNLUJKZCLTLHU-UHFFFAOYSA-N	377620	US10266495, Compound I-32::4-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377620&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866766	404346587							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755344	COc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1-n1cnnn1	InChI=1S/C18H15ClN6O2/c1-27-17-8-14(3-5-16(17)25-10-21-23-24-25)20-9-12-6-11-7-13(19)2-4-15(11)22-18(12)26/h2-8,10,20H,9H2,1H3,(H,22,26)	NITCQMNPAJNNEX-UHFFFAOYSA-N	377621	US10266495, Compound I-33::6-chloro-3-({[3-methoxy-4-(1H-1,2,3,4-tetrazol-1-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377621&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866767	404346588							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755346	COc1cc(ccc1NCc1cc2cc(Cl)ccc2[nH]c1=O)C#N	InChI=1S/C18H14ClN3O2/c1-24-17-6-11(9-20)2-4-16(17)21-10-13-7-12-8-14(19)3-5-15(12)22-18(13)23/h2-8,21H,10H2,1H3,(H,22,23)	HCZKGKHYRPTOOB-UHFFFAOYSA-N	377622	US10266495, Compound I-34::4-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377622&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866768	404346589							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755347	FC(F)(F)c1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C18H11ClF3N3O/c19-13-2-4-16-11(6-13)5-12(17(26)25-16)9-24-14-3-1-10(8-23)15(7-14)18(20,21)22/h1-7,24H,9H2,(H,25,26)	OBQGWFJLHSLUJJ-UHFFFAOYSA-N	377623	US10266495, Compound I-35::4-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377623&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866769	404346590							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755348	Cc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C18H14ClN3O/c1-11-6-16(4-2-12(11)9-20)21-10-14-7-13-8-15(19)3-5-17(13)22-18(14)23/h2-8,21H,10H2,1H3,(H,22,23)	PEMDUUPRWVAMBW-UHFFFAOYSA-N	377624	US10266495, Compound I-36::4-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377624&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866770	404346591							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755350	Fc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C17H11ClFN3O/c18-13-2-4-16-11(6-13)5-12(17(23)22-16)9-21-14-3-1-10(8-20)15(19)7-14/h1-7,21H,9H2,(H,22,23)	KZRMUFFPMBYBAV-UHFFFAOYSA-N	377625	US10266495, Compound I-37::4-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377625&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866771	404346592							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755351	Cc1nnnn1-c1ccc(NCc2cc3cc(Cl)ccc3[nH]c2=O)cc1	InChI=1S/C18H15ClN6O/c1-11-22-23-24-25(11)16-5-3-15(4-6-16)20-10-13-8-12-9-14(19)2-7-17(12)21-18(13)26/h2-9,20H,10H2,1H3,(H,21,26)	YTNJBJHNTIQCJD-UHFFFAOYSA-N	377626	US10266495, Compound I-38::6-chloro-3-({[4-(5-methyl-1H-1,2,3,4-tetrazol-1-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377626&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866772	404346593							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755353	Clc1ccc2[nH]c(=O)c(CNc3ccc(cc3)-n3ccnc3)cc2c1	InChI=1S/C19H15ClN4O/c20-15-1-6-18-13(10-15)9-14(19(25)23-18)11-22-16-2-4-17(5-3-16)24-8-7-21-12-24/h1-10,12,22H,11H2,(H,23,25)	GZMDTIGASLPUGG-UHFFFAOYSA-N	377627	US10266495, Compound I-39::6-chloro-3-({[4-(1H-imidazol-1-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377627&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866773	404346594							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755354	NC(=O)c1ccccc1NCc1cc2cc(Cl)ccc2[nH]c1=O	InChI=1S/C17H14ClN3O2/c18-12-5-6-14-10(8-12)7-11(17(23)21-14)9-20-15-4-2-1-3-13(15)16(19)22/h1-8,20H,9H2,(H2,19,22)(H,21,23)	DXEOWXWIQFRZFF-UHFFFAOYSA-N	377628	US10266495, Compound I-40::2-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377628&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866774	404346595							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755355	COc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1F	InChI=1S/C17H14ClFN2O2/c1-23-16-8-13(3-4-14(16)19)20-9-11-6-10-7-12(18)2-5-15(10)21-17(11)22/h2-8,20H,9H2,1H3,(H,21,22)	VKHICLNCSJFWDX-UHFFFAOYSA-N	377629	US10266495, Compound I-41::6-chloro-3-{[(4-fluoro-3-methoxyphenyl)amino]methyl}-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377629&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866775	404346596							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755356	CNC(=O)c1ccc(NCc2cc3cc(Cl)ccc3[nH]c2=O)cc1	InChI=1S/C18H16ClN3O2/c1-20-17(23)11-2-5-15(6-3-11)21-10-13-8-12-9-14(19)4-7-16(12)22-18(13)24/h2-9,21H,10H2,1H3,(H,20,23)(H,22,24)	ASUSIIKTTAIBGT-UHFFFAOYSA-N	377630	US10266495, Compound I-42::4-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377630&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866776	404346597							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755357	NC(=O)COc1ccc(NCc2cc3cc(Cl)ccc3[nH]c2=O)cc1	InChI=1S/C18H16ClN3O3/c19-13-1-6-16-11(8-13)7-12(18(24)22-16)9-21-14-2-4-15(5-3-14)25-10-17(20)23/h1-8,21H,9-10H2,(H2,20,23)(H,22,24)	YJGBUZBRZWAILQ-UHFFFAOYSA-N	377631	US10266495, Compound I-43::2-(4-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377631&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866777	404346598							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755358	COc1cc(NCc2cc3cc(Cl)ccc3[nH]c2=O)ccc1Cl	InChI=1S/C17H14Cl2N2O2/c1-23-16-8-13(3-4-14(16)19)20-9-11-6-10-7-12(18)2-5-15(10)21-17(11)22/h2-8,20H,9H2,1H3,(H,21,22)	VANIVOXAWYHYDG-UHFFFAOYSA-N	377632	US10266495, Compound I-44::6-chloro-3-{[(4-chloro-3-methoxyphenyl)amino]methyl}-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377632&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866778	404346599							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755359	Clc1ccc2[nH]c(=O)c(CNc3cccc(CC#N)c3)cc2c1	InChI=1S/C18H14ClN3O/c19-15-4-5-17-13(10-15)9-14(18(23)22-17)11-21-16-3-1-2-12(8-16)6-7-20/h1-5,8-10,21H,6,11H2,(H,22,23)	GTRKMNHLUOBDBB-UHFFFAOYSA-N	377633	US10266495, Compound I-45::2-(3-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377633&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866779	404346600							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755360	Fc1ccccc1NCc1cc2cc(Cl)ccc2[nH]c1=O	InChI=1S/C16H12ClFN2O/c17-12-5-6-14-10(8-12)7-11(16(21)20-14)9-19-15-4-2-1-3-13(15)18/h1-8,19H,9H2,(H,20,21)	MIILUWVKYRBFAP-UHFFFAOYSA-N	377634	US10266495, Compound I-46::6-chloro-3-{[(2-fluorophenyl)amino]methyl}-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377634&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866780	404346601							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755361	COc1cc(NCc2cc3ccccc3[nH]c2=O)ccc1C#N	InChI=1S/C18H15N3O2/c1-23-17-9-15(7-6-13(17)10-19)20-11-14-8-12-4-2-3-5-16(12)21-18(14)22/h2-9,20H,11H2,1H3,(H,21,22)	LPHVOAHPNPOSNP-UHFFFAOYSA-N	377635	US10266495, Compound I-47::2-methoxy-4-{[(2-oxo-1,2-dihydroquinolin-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377635&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866781	404346602							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755363	COc1cc(NCc2cc3ccccc3[nH]c2=O)ccc1-n1cnnn1	InChI=1S/C18H16N6O2/c1-26-17-9-14(6-7-16(17)24-11-20-22-23-24)19-10-13-8-12-4-2-3-5-15(12)21-18(13)25/h2-9,11,19H,10H2,1H3,(H,21,25)	JGXVUDGASVPOGG-UHFFFAOYSA-N	377636	US10266495, Compound I-48::3-({[3-methoxy-4-(1H-1,2,3,4-tetrazol-1-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377636&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			75260687	404346603							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755364	O=c1[nH]c2ccccc2cc1CNc1ccc(cc1)-n1cnnn1	InChI=1S/C17H14N6O/c24-17-13(9-12-3-1-2-4-16(12)20-17)10-18-14-5-7-15(8-6-14)23-11-19-21-22-23/h1-9,11,18H,10H2,(H,20,24)	IIMGWBMBLASITC-UHFFFAOYSA-N	377637	US10266495, Compound I-49::3-({[4-(1H-1,2,3,4-tetrazol-1-yl)phenyl]amino}methyl)-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377637&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866782	404346604							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755365	COc1cc(NCc2cc3cc(C)ccc3[nH]c2=O)ccc1C#N	InChI=1S/C19H17N3O2/c1-12-3-6-17-14(7-12)8-15(19(23)22-17)11-21-16-5-4-13(10-20)18(9-16)24-2/h3-9,21H,11H2,1-2H3,(H,22,23)	WELQRSQWBDNFGC-UHFFFAOYSA-N	377638	US10266495, Compound I-50::2-methoxy-4-{[(6-methyl-2-oxo-1,2-dihydroquinolin-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377638&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866783	404346605							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755366	Cc1cc2cc(CNc3ccc(cc3)-n3cnnn3)c(=O)[nH]c2cc1C	InChI=1S/C19H18N6O/c1-12-7-14-9-15(19(26)22-18(14)8-13(12)2)10-20-16-3-5-17(6-4-16)25-11-21-23-24-25/h3-9,11,20H,10H2,1-2H3,(H,22,26)	UNQLYSBMVVGBRH-UHFFFAOYSA-N	377639	US10266495, Compound I-51::6,7-dimethyl-3-({[4-(1H-1,2,3,4-tetrazol-1-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377639&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866784	404346606							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755367	COc1ccc2[nH]c(=O)c(CNc3ccc(C#N)c(OC)c3)cc2c1	InChI=1S/C19H17N3O3/c1-24-16-5-6-17-13(8-16)7-14(19(23)22-17)11-21-15-4-3-12(10-20)18(9-15)25-2/h3-9,21H,11H2,1-2H3,(H,22,23)	GSWUVXVESIYSLI-UHFFFAOYSA-N	377640	US10266495, Compound I-52::2-methoxy-4-{[(6-methoxy-2-oxo-1,2-dihydroquinolin-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377640&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866785	404346607							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755368	COc1ccc2[nH]c(=O)c(CNc3ccc(cc3)-n3ccnc3)cc2c1	InChI=1S/C20H18N4O2/c1-26-18-6-7-19-14(11-18)10-15(20(25)23-19)12-22-16-2-4-17(5-3-16)24-9-8-21-13-24/h2-11,13,22H,12H2,1H3,(H,23,25)	FETJLCYBKCVBKT-UHFFFAOYSA-N	377641	US10266495, Compound I-53::3-({[4-(1H-imidazol-1-yl)phenyl]amino}methyl)-6-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>1000							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377641&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866786	404346608							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755369	COc1cc(NCc2cc3ccc(C)cc3[nH]c2=O)ccc1C#N	InChI=1S/C19H17N3O2/c1-12-3-4-13-8-15(19(23)22-17(13)7-12)11-21-16-6-5-14(10-20)18(9-16)24-2/h3-9,21H,11H2,1-2H3,(H,22,23)	HYZMLMIAPFRYEP-UHFFFAOYSA-N	377642	US10266495, Compound I-54::2-methoxy-4-{[(7-methyl-2-oxo-1,2-dihydroquinolin-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377642&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866787	404346609							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755370	CCOc1ccc2[nH]c(=O)c(CNc3ccc(C#N)c(OC)c3)cc2c1	InChI=1S/C20H19N3O3/c1-3-26-17-6-7-18-14(9-17)8-15(20(24)23-18)12-22-16-5-4-13(11-21)19(10-16)25-2/h4-10,22H,3,12H2,1-2H3,(H,23,24)	WKFONSVAHXVCCD-UHFFFAOYSA-N	377643	US10266495, Compound I-55::4-{[(6-ethoxy-2-oxo-1,2-dihydroquinolin-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377643&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866788	404346610							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755371	COc1ccc2cc(CNc3ccc(C#N)c(OC)c3)c(=O)[nH]c2c1	InChI=1S/C19H17N3O3/c1-24-16-6-4-12-7-14(19(23)22-17(12)9-16)11-21-15-5-3-13(10-20)18(8-15)25-2/h3-9,21H,11H2,1-2H3,(H,22,23)	AILNNOASKOKXGB-UHFFFAOYSA-N	377644	US10266495, Compound I-56::2-methoxy-4-{[(7-methoxy-2-oxo-1,2-dihydroquinolin-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377644&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866789	404346611							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755372	COc1cc(NCc2cc3cc(Cl)c(O)cc3[nH]c2=O)ccc1C#N	InChI=1S/C18H14ClN3O3/c1-25-17-6-13(3-2-10(17)8-20)21-9-12-4-11-5-14(19)16(23)7-15(11)22-18(12)24/h2-7,21,23H,9H2,1H3,(H,22,24)	TWJATQSBXORYQQ-UHFFFAOYSA-N	377645	US10266495, Compound I-57::4-{[(6-chloro-7-hydroxy-2-oxo-1,2-dihydroquinolin-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377645&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866790	404346612							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755373	COc1cc(NCc2cc3cc(Cl)c(OCc4ccccn4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H19ClN4O3/c1-31-22-10-18(6-5-15(22)12-26)28-13-17-8-16-9-20(25)23(11-21(16)29-24(17)30)32-14-19-4-2-3-7-27-19/h2-11,28H,13-14H2,1H3,(H,29,30)	NRASQWAHCMHZAP-UHFFFAOYSA-N	377646	US10266495, Compound I-58::4-({[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377646&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866791	404346613							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755375	COc1cc(NCc2cc3cc(Cl)c(OCC(O)CN4CCOCC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H27ClN4O5/c1-33-23-10-19(3-2-16(23)12-27)28-13-18-8-17-9-21(26)24(11-22(17)29-25(18)32)35-15-20(31)14-30-4-6-34-7-5-30/h2-3,8-11,20,28,31H,4-7,13-15H2,1H3,(H,29,32)	PWEFSJMBJSQTBI-UHFFFAOYSA-N	377647	US10266495, Compound I-59::4-[({6-chloro-7-[2-hydroxy-3-(morpholin-4-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377647&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866792	404346614							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755377	COc1cc(NCc2cc3cc(Cl)c(OCCN4CCOCC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H25ClN4O4/c1-31-22-12-19(3-2-16(22)14-26)27-15-18-10-17-11-20(25)23(13-21(17)28-24(18)30)33-9-6-29-4-7-32-8-5-29/h2-3,10-13,27H,4-9,15H2,1H3,(H,28,30)	CWJLOFYZEOVYFQ-UHFFFAOYSA-N	377648	US10266495, Compound I-60::4-[({6-chloro-7-[2-(morpholin-4-yl)ethoxy]-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377648&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866793	404346615							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755379	COc1cc(NCc2cc3cc(Cl)c(OCCN(C)C)cc3[nH]c2=O)ccc1C#N	InChI=1S/C22H23ClN4O3/c1-27(2)6-7-30-21-11-19-15(9-18(21)23)8-16(22(28)26-19)13-25-17-5-4-14(12-24)20(10-17)29-3/h4-5,8-11,25H,6-7,13H2,1-3H3,(H,26,28)	VSNNNQAXGFVANM-UHFFFAOYSA-N	377649	US10266495, Compound I-61::4-[({6-chloro-7-[2-(dimethylamino)ethoxy]-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377649&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866794	404346616							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755381	COc1cc(NCc2cc3cc(Cl)c(OCc4cccnc4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H19ClN4O3/c1-31-22-9-19(5-4-16(22)11-26)28-13-18-7-17-8-20(25)23(10-21(17)29-24(18)30)32-14-15-3-2-6-27-12-15/h2-10,12,28H,13-14H2,1H3,(H,29,30)	PZFURKFSHLGJCY-UHFFFAOYSA-N	377650	US10266495, Compound I-62::4-({[6-chloro-2-oxo-7-(pyridin-3-ylmethoxy)-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377650&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866795	404346617							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755383	COc1cc(NCc2cc3cc(Cl)c(OCC4CCOCC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H24ClN3O4/c1-30-22-10-19(3-2-16(22)12-26)27-13-18-8-17-9-20(25)23(11-21(17)28-24(18)29)32-14-15-4-6-31-7-5-15/h2-3,8-11,15,27H,4-7,13-14H2,1H3,(H,28,29)	NYSSOJQKFSDYTD-UHFFFAOYSA-N	377651	US10266495, Compound I-63::4-({[6-chloro-7-(oxan-4-ylmethoxy)-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377651&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866796	404346618							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755385	COc1cc(NCc2cc3cc(Cl)c(OCCN4CCN(CC4)S(C)(=O)=O)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H28ClN5O5S/c1-35-23-13-20(4-3-17(23)15-27)28-16-19-11-18-12-21(26)24(14-22(18)29-25(19)32)36-10-9-30-5-7-31(8-6-30)37(2,33)34/h3-4,11-14,28H,5-10,16H2,1-2H3,(H,29,32)	CUKDDYYYWUICSQ-UHFFFAOYSA-N	377652	US10266495, Compound I-64::4-[({6-chloro-7-[2-(4-methanesulfonylpiperazin-1-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377652&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866797	404346619							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755387	COc1cc(NCc2cc3cc(Cl)c(OC[C@H]4CCOC4)cc3[nH]c2=O)ccc1C#N |r|	InChI=1S/C23H22ClN3O4/c1-29-21-8-18(3-2-15(21)10-25)26-11-17-6-16-7-19(24)22(9-20(16)27-23(17)28)31-13-14-4-5-30-12-14/h2-3,6-9,14,26H,4-5,11-13H2,1H3,(H,27,28)	GBASNBSJKNSNDD-UHFFFAOYSA-N	377653	US10266495, Compound I-65::4-[({6-chloro-2-oxo-7-[(3S)-oxolan-3-ylmethoxy]-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377653	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377653&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866798	404346620							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755389	COc1cc(NCc2cc3cc(Cl)c(OC4CCN(C)CC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H25ClN4O3/c1-29-7-5-19(6-8-29)32-23-12-21-16(10-20(23)25)9-17(24(30)28-21)14-27-18-4-3-15(13-26)22(11-18)31-2/h3-4,9-12,19,27H,5-8,14H2,1-2H3,(H,28,30)	WXTNBBYABWLYTK-UHFFFAOYSA-N	377654	US10266495, Compound I-66::4-[({6-chloro-7-[(1-methylpiperidin-4-yl)oxy]-2-oxo-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377654&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866799	404346621							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755391	COc1cc(NCc2cc3cc(Cl)c(OCC(=O)N(C)C)cc3[nH]c2=O)ccc1C#N	InChI=1S/C22H21ClN4O4/c1-27(2)21(28)12-31-20-9-18-14(7-17(20)23)6-15(22(29)26-18)11-25-16-5-4-13(10-24)19(8-16)30-3/h4-9,25H,11-12H2,1-3H3,(H,26,29)	FAQBAUNUPUIYJU-UHFFFAOYSA-N	377655	US10266495, Compound I-67::2-[(6-chloro-3-{[(4-cyano-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377655	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377655&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866800	404346622							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755393	COc1cc(NCc2cc3cc(Cl)c(OCC(N)=O)cc3[nH]c2=O)ccc1C#N	InChI=1S/C20H17ClN4O4/c1-28-17-6-14(3-2-11(17)8-22)24-9-13-4-12-5-15(21)18(29-10-19(23)26)7-16(12)25-20(13)27/h2-7,24H,9-10H2,1H3,(H2,23,26)(H,25,27)	BHOQCOWIIIQYHF-UHFFFAOYSA-N	377656	US10266495, Compound I-68::2-[(6-chloro-3-{[(4-cyano-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377656	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377656&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866801	404346623							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755395	COc1cc(NCc2cc3cc(Cl)c(OCC(=O)N4CCOCC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H23ClN4O5/c1-32-21-10-18(3-2-15(21)12-26)27-13-17-8-16-9-19(25)22(11-20(16)28-24(17)31)34-14-23(30)29-4-6-33-7-5-29/h2-3,8-11,27H,4-7,13-14H2,1H3,(H,28,31)	YOLJPYAFGCDCOX-UHFFFAOYSA-N	377657	US10266495, Compound I-69::4-[({6-chloro-7-[2-(morpholin-4-yl)-2-oxoethoxy]-2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377657&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866802	404346624							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755397	COc1cc(NCc2cc3cc(Cl)c(OCc4cc(C)n(C)n4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H22ClN5O3/c1-14-6-19(29-30(14)2)13-33-23-10-21-16(8-20(23)25)7-17(24(31)28-21)12-27-18-5-4-15(11-26)22(9-18)32-3/h4-10,27H,12-13H2,1-3H3,(H,28,31)	XHFLRLFPWAYZQN-UHFFFAOYSA-N	377658	US10266495, Compound I-70::4-[({6-chloro-7-[(1,5-dimethyl-1H-pyrazol-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377658	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377658&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866803	404346625							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755399	COc1cc(NCc2cc3cc(Cl)c(OCc4ccccc4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H20ClN3O3/c1-31-23-11-20(8-7-17(23)13-27)28-14-19-9-18-10-21(26)24(12-22(18)29-25(19)30)32-15-16-5-3-2-4-6-16/h2-12,28H,14-15H2,1H3,(H,29,30)	VJOKHRHCQQMVSN-UHFFFAOYSA-N	377659	US10266495, Compound I-71::4-({[7-(benzyloxy)-6-chloro-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377659&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866804	404346626							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755401	COc1cc(NCc2cc3cc(Cl)c(OCC4CCCCN4C)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H27ClN4O3/c1-30-8-4-3-5-20(30)15-33-24-12-22-17(10-21(24)26)9-18(25(31)29-22)14-28-19-7-6-16(13-27)23(11-19)32-2/h6-7,9-12,20,28H,3-5,8,14-15H2,1-2H3,(H,29,31)	SNBIPUDRMOXTPE-UHFFFAOYSA-N	377660	US10266495, Compound I-72::4-[({6-chloro-7-[(1-methylpiperidin-2-yl)methoxy]-2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377660	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377660&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866805	404346627							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755403	COc1cc(NCc2cc3cc(Cl)c(OCc4ccnc(C)c4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H21ClN4O3/c1-15-7-16(5-6-28-15)14-33-24-11-22-18(9-21(24)26)8-19(25(31)30-22)13-29-20-4-3-17(12-27)23(10-20)32-2/h3-11,29H,13-14H2,1-2H3,(H,30,31)	GGIFPTBUAYFJGZ-UHFFFAOYSA-N	377661	US10266495, Compound I-73::4-[({6-chloro-7-[(2-methylpyridin-4-yl)methoxy]-2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377661&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866806	404346628							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755404	COc1cc(NCc2cc3cc(Cl)c(OCc4ccncc4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H19ClN4O3/c1-31-22-10-19(3-2-16(22)12-26)28-13-18-8-17-9-20(25)23(11-21(17)29-24(18)30)32-14-15-4-6-27-7-5-15/h2-11,28H,13-14H2,1H3,(H,29,30)	LUMAMFZEXNQSKB-UHFFFAOYSA-N	377662	US10266495, Compound I-74::4-({[6-chloro-2-oxo-7-(pyridin-4-ylmethoxy)-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377662	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377662&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866807	404346629							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755406	COc1cc(NCc2cc3cc(Cl)c(OCC4CCS(=O)(=O)CC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H24ClN3O5S/c1-32-22-10-19(3-2-16(22)12-26)27-13-18-8-17-9-20(25)23(11-21(17)28-24(18)29)33-14-15-4-6-34(30,31)7-5-15/h2-3,8-11,15,27H,4-7,13-14H2,1H3,(H,28,29)	BYTHIWYWHFZDAG-UHFFFAOYSA-N	377663	US10266495, Compound I-75::4-[({6-chloro-7-[(1,1-dioxo-1lambda6-thian-4-yl)methoxy]-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377663	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377663&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866808	404346630							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755408	COc1cc(NCc2cc3cc(Cl)c(OCc4cnccn4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C23H18ClN5O3/c1-31-21-8-17(3-2-14(21)10-25)28-11-16-6-15-7-19(24)22(9-20(15)29-23(16)30)32-13-18-12-26-4-5-27-18/h2-9,12,28H,11,13H2,1H3,(H,29,30)	MAMKQZAUYSSTJE-UHFFFAOYSA-N	377664	US10266495, Compound I-76::4-({[6-chloro-2-oxo-7-(pyrazin-2-ylmethoxy)-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377664	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377664&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866809	404346631							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755410	COc1cc(NCc2cc3cc(Cl)c(OCc4cncn4C)cc3[nH]c2=O)ccc1C#N	InChI=1S/C23H20ClN5O3/c1-29-13-26-11-18(29)12-32-22-8-20-15(6-19(22)24)5-16(23(30)28-20)10-27-17-4-3-14(9-25)21(7-17)31-2/h3-8,11,13,27H,10,12H2,1-2H3,(H,28,30)	XBRVTKHNQJZBOM-UHFFFAOYSA-N	377665	US10266495, Compound I-77::4-[({6-chloro-7-[(1-methyl-1H-imidazol-5-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377665	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377665&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866810	404346632							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755412	COc1cc(NCc2cc3cc(Cl)c(OCc4nccn4C)cc3[nH]c2=O)ccc1C#N	InChI=1S/C23H20ClN5O3/c1-29-6-5-26-22(29)13-32-21-10-19-15(8-18(21)24)7-16(23(30)28-19)12-27-17-4-3-14(11-25)20(9-17)31-2/h3-10,27H,12-13H2,1-2H3,(H,28,30)	ZNNYIZWXQHUQAE-UHFFFAOYSA-N	377666	US10266495, Compound I-78::4-[({6-chloro-7-[(1-methyl-1H-imidazol-2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377666	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377666&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866811	404346633							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755414	COc1cc(NCc2cc3cc(Cl)c(OCc4nc(no4)C(N)=O)cc3[nH]c2=O)ccc1C#N	InChI=1S/C22H17ClN6O5/c1-32-17-6-14(3-2-11(17)8-24)26-9-13-4-12-5-15(23)18(7-16(12)27-22(13)31)33-10-19-28-21(20(25)30)29-34-19/h2-7,26H,9-10H2,1H3,(H2,25,30)(H,27,31)	MXJDLEVWMIQVAZ-UHFFFAOYSA-N	377667	US10266495, Compound I-79::5-{[(6-chloro-3-{[(4-cyano-3-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377667	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377667&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866812	404346634							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755416	COc1cc(NCc2cc3cc(Cl)c(OCCc4ccccn4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H21ClN4O3/c1-32-23-12-20(6-5-16(23)14-27)29-15-18-10-17-11-21(26)24(13-22(17)30-25(18)31)33-9-7-19-4-2-3-8-28-19/h2-6,8,10-13,29H,7,9,15H2,1H3,(H,30,31)	ZKPLTVZRYJMSDR-UHFFFAOYSA-N	377668	US10266495, Compound I-80::4-[({6-chloro-2-oxo-7-[2-(pyridin-2-yl)ethoxy]-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377668	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377668&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866813	404346635							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755418	COc1cc(NCc2cc3cc(Cl)c(OCCc4ccncc4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H21ClN4O3/c1-32-23-12-20(3-2-17(23)14-27)29-15-19-10-18-11-21(26)24(13-22(18)30-25(19)31)33-9-6-16-4-7-28-8-5-16/h2-5,7-8,10-13,29H,6,9,15H2,1H3,(H,30,31)	QDVONHZHLDMQJV-UHFFFAOYSA-N	377669	US10266495, Compound I-81::4-[({6-chloro-2-oxo-7-[2-(pyridin-4-yl)ethoxy]-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377669	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377669&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866814	404346636							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755420	COc1cc(NCc2cc3cc(Cl)c(OCCCN(C)C)cc3[nH]c2=O)ccc1C#N	InChI=1S/C23H25ClN4O3/c1-28(2)7-4-8-31-22-12-20-16(10-19(22)24)9-17(23(29)27-20)14-26-18-6-5-15(13-25)21(11-18)30-3/h5-6,9-12,26H,4,7-8,14H2,1-3H3,(H,27,29)	JDBMLADWDOHSJS-UHFFFAOYSA-N	377670	US10266495, Compound I-82::4-[({6-chloro-7-[3-(dimethylamino)propoxy]-2-oxo-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377670	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377670&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866815	404346637							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755422	COc1cc(NCc2cc3cc(Cl)c(OCCCN4CCCC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H27ClN4O3/c1-32-23-13-20(6-5-17(23)15-27)28-16-19-11-18-12-21(26)24(14-22(18)29-25(19)31)33-10-4-9-30-7-2-3-8-30/h5-6,11-14,28H,2-4,7-10,16H2,1H3,(H,29,31)	CUGQFMLSKRUENL-UHFFFAOYSA-N	377671	US10266495, Compound I-83::4-[({6-chloro-2-oxo-7-[3-(pyrrolidin-1-yl)propoxy]-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377671	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377671&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866816	404346638							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755424	COc1cc(NCc2cc3cc(Cl)c(OCCCN4CCCCC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C26H29ClN4O3/c1-33-24-14-21(7-6-18(24)16-28)29-17-20-12-19-13-22(27)25(15-23(19)30-26(20)32)34-11-5-10-31-8-3-2-4-9-31/h6-7,12-15,29H,2-5,8-11,17H2,1H3,(H,30,32)	PIAOIQPQNWUOFI-UHFFFAOYSA-N	377672	US10266495, Compound I-84::4-[({6-chloro-2-oxo-7-[3-(piperidin-1-yl)propoxy]-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377672	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377672&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866817	404346639							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755426	COc1cc(NCc2cc3cc(Cl)c(OCCN4CCCC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H25ClN4O3/c1-31-22-12-19(5-4-16(22)14-26)27-15-18-10-17-11-20(25)23(13-21(17)28-24(18)30)32-9-8-29-6-2-3-7-29/h4-5,10-13,27H,2-3,6-9,15H2,1H3,(H,28,30)	MSZKIFCUJHHGFO-UHFFFAOYSA-N	377673	US10266495, Compound I-85::4-[({6-chloro-2-oxo-7-[2-(pyrrolidin-1-yl)ethoxy]-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377673	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377673&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866818	404346640							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755428	COc1cc(NCc2cc3cc(Cl)c(OCCN4CCCC4=O)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H23ClN4O4/c1-32-21-11-18(5-4-15(21)13-26)27-14-17-9-16-10-19(25)22(12-20(16)28-24(17)31)33-8-7-29-6-2-3-23(29)30/h4-5,9-12,27H,2-3,6-8,14H2,1H3,(H,28,31)	OUSJMTATPGEBST-UHFFFAOYSA-N	377674	US10266495, Compound I-86::4-[({6-chloro-2-oxo-7-[2-(2-oxopyrrolidin-1-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377674	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377674&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866819	404346641							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755430	COc1cc(NCc2cc3cc(Cl)c(OCCN4CCCCC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H27ClN4O3/c1-32-23-13-20(6-5-17(23)15-27)28-16-19-11-18-12-21(26)24(14-22(18)29-25(19)31)33-10-9-30-7-3-2-4-8-30/h5-6,11-14,28H,2-4,7-10,16H2,1H3,(H,29,31)	CTMYLAQMJOILMA-UHFFFAOYSA-N	377675	US10266495, Compound I-87::4-[({6-chloro-2-oxo-7-[2-(piperidin-1-yl)ethoxy]-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377675	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377675&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866820	404346642							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755432	COc1cc(NCc2cc3cc(Cl)c(OCCN4CCN(C)CC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H28ClN5O3/c1-30-5-7-31(8-6-30)9-10-34-24-14-22-18(12-21(24)26)11-19(25(32)29-22)16-28-20-4-3-17(15-27)23(13-20)33-2/h3-4,11-14,28H,5-10,16H2,1-2H3,(H,29,32)	XRGWIHWIKBCYHZ-UHFFFAOYSA-N	377676	US10266495, Compound I-88::4-[({6-chloro-7-[2-(4-methylpiperazin-1-yl)ethoxy]-2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377676	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377676&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866821	404346643							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755434	COc1cc(NCc2cc3cc(Cl)c(OCCn4ccnc4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C23H20ClN5O3/c1-31-21-10-18(3-2-15(21)12-25)27-13-17-8-16-9-19(24)22(11-20(16)28-23(17)30)32-7-6-29-5-4-26-14-29/h2-5,8-11,14,27H,6-7,13H2,1H3,(H,28,30)	JVVZGQLJZNKJNR-UHFFFAOYSA-N	377677	US10266495, Compound I-89::4-[({6-chloro-7-[2-(1H-imidazol-1-yl)ethoxy]-2-oxo-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377677	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377677&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866822	404346644							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755436	COc1cc(NCc2cc3cc(Cl)c(OCCn4ccnc4C)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H22ClN5O3/c1-15-27-5-6-30(15)7-8-33-23-12-21-17(10-20(23)25)9-18(24(31)29-21)14-28-19-4-3-16(13-26)22(11-19)32-2/h3-6,9-12,28H,7-8,14H2,1-2H3,(H,29,31)	LWWFYUMGJBBWIN-UHFFFAOYSA-N	377678	US10266495, Compound I-90::4-[({6-chloro-7-[2-(2-methyl-1H-imidazol-1-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377678	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377678&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866823	404346645							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755438	COc1cc(NCc2cc3cc(Cl)c(OCCN4CCS(=O)(=O)CC4)cc3[nH]c2=O)ccc1C#N	InChI=1S/C24H25ClN4O5S/c1-33-22-12-19(3-2-16(22)14-26)27-15-18-10-17-11-20(25)23(13-21(17)28-24(18)30)34-7-4-29-5-8-35(31,32)9-6-29/h2-3,10-13,27H,4-9,15H2,1H3,(H,28,30)	CKUQYUUOKYQJPI-UHFFFAOYSA-N	377679	US10266495, Compound I-91::4-[({6-chloro-7-[2-(1,1-dioxo-1lambda6,4-thiomorpholin-4-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377679	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377679&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866824	404346646							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755440	COc1cc(NCc2cc3cc(Cl)c(OCCn4nc(C)cc4C)cc3[nH]c2=O)ccc1C#N	InChI=1S/C25H24ClN5O3/c1-15-8-16(2)31(30-15)6-7-34-24-12-22-18(10-21(24)26)9-19(25(32)29-22)14-28-20-5-4-17(13-27)23(11-20)33-3/h4-5,8-12,28H,6-7,14H2,1-3H3,(H,29,32)	ZANYSXIWJIXTEB-UHFFFAOYSA-N	377680	US10266495, Compound I-92::4-[({6-chloro-7-[2-(3,5-dimethyl-1H-pyrazol-1-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377680	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377680&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866825	404346647							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755442	CCOCCOc1cc2[nH]c(=O)c(CNc3ccc(cc3)C#N)cc2cc1Cl	InChI=1S/C21H20ClN3O3/c1-2-27-7-8-28-20-11-19-15(10-18(20)22)9-16(21(26)25-19)13-24-17-5-3-14(12-23)4-6-17/h3-6,9-11,24H,2,7-8,13H2,1H3,(H,25,26)	FVZZYVZPLNWLDH-UHFFFAOYSA-N	377681	US10266495, Compound I-93::4-({[6-chloro-7-(2-ethoxyethoxy)-2-oxo-1,2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377681	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377681&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866826	404346648							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755443	COc1cc(NCc2cc3cc(Cl)c(OC[C@@H]4CCCN4C)cc3[nH]c2=O)ccc1C#N |r|	InChI=1S/C24H25ClN4O3/c1-29-7-3-4-19(29)14-32-23-11-21-16(9-20(23)25)8-17(24(30)28-21)13-27-18-6-5-15(12-26)22(10-18)31-2/h5-6,8-11,19,27H,3-4,7,13-14H2,1-2H3,(H,28,30)	AUSQEMWCDVUKEF-UHFFFAOYSA-N	377682	US10266495, Compound I-94::4-{[(6-chloro-7-{[(2S)-1-methylpyrrolidin-2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377682	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377682&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866827	404346649							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755445	COc1cc(NCc2cc3cc(Cl)cc(C)c3[nH]c2=O)ccc1C#N	InChI=1S/C19H16ClN3O2/c1-11-5-15(20)7-13-6-14(19(24)23-18(11)13)10-22-16-4-3-12(9-21)17(8-16)25-2/h3-8,22H,10H2,1-2H3,(H,23,24)	VXQVZYJIBKUGQX-UHFFFAOYSA-N	377683	US10266495, Compound I-95::4-{[(6-chloro-8-methyl-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377683&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866828	404346650							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755447	COc1cc(NCc2cc3cc(Cl)cc(O)c3[nH]c2=O)ccc1C#N	InChI=1S/C18H14ClN3O3/c1-25-16-7-14(3-2-10(16)8-20)21-9-12-4-11-5-13(19)6-15(23)17(11)22-18(12)24/h2-7,21,23H,9H2,1H3,(H,22,24)	WMBXUFNMIPSXHK-UHFFFAOYSA-N	377684	US10266495, Compound I-96::4-{[(6-chloro-8-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377684	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377684&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866829	404346651							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755448	COc1cc(NCc2cc3cc(Cl)cc(OC)c3[nH]c2=O)ccc1C#N	InChI=1S/C19H16ClN3O3/c1-25-16-8-15(4-3-11(16)9-21)22-10-13-5-12-6-14(20)7-17(26-2)18(12)23-19(13)24/h3-8,22H,10H2,1-2H3,(H,23,24)	CQVRJZBBBURMFP-UHFFFAOYSA-N	377685	US10266495, Compound I-97::4-{[(6-chloro-8-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377685	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377685&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866830	404346652							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755450	COc1cc(NCc2cc3cc(Cl)cc(OCc4ccccn4)c3[nH]c2=O)ccc1C#N	InChI=1S/C24H19ClN4O3/c1-31-21-11-19(6-5-15(21)12-26)28-13-17-8-16-9-18(25)10-22(23(16)29-24(17)30)32-14-20-4-2-3-7-27-20/h2-11,28H,13-14H2,1H3,(H,29,30)	ARZTYPQTGCGOHE-UHFFFAOYSA-N	377686	US10266495, Compound I-98::4-({[6-chloro-2-oxo-8-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377686	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377686&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866831	404346653							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755452	COc1cc(NCc2cc3cc(Cl)cc(OCCN4CCOCC4)c3[nH]c2=O)ccc1C#N	InChI=1S/C24H25ClN4O4/c1-31-21-13-20(3-2-16(21)14-26)27-15-18-10-17-11-19(25)12-22(23(17)28-24(18)30)33-9-6-29-4-7-32-8-5-29/h2-3,10-13,27H,4-9,15H2,1H3,(H,28,30)	BDNAALPRTZXITM-UHFFFAOYSA-N	377687	US10266495, Compound I-99::4-[({6-chloro-8-[2-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377687	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377687&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866832	404346654							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
755454	COc1cc(NCc2cc3cc(Cl)cc(OCCN4CCCC4)c3[nH]c2=O)ccc1C#N	InChI=1S/C24H25ClN4O3/c1-31-21-13-20(5-4-16(21)14-26)27-15-18-10-17-11-19(25)12-22(23(17)28-24(18)30)32-9-8-29-6-2-3-7-29/h4-5,10-13,27H,2-3,6-9,15H2,1H3,(H,28,30)	KLQXWNJVVYZFDQ-UHFFFAOYSA-N	377688	US10266495, Compound I-100::4-[({6-chloro-2-oxo-8-	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2XK8HV9		aid1798376	US10266496	Yang, X; Huang, C; Ma, F; Zhang, J; Wang, X; Zhang, Y	4/23/2019	2/7/2020	Sunshine Lake Pharma	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=377688	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=377688&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145866833	404346655							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766484	C[C@H](Nc1nccc(n1)N(CC(C)(C)C)S(C)(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H26ClN5O3S/c1-13(16-11-14-10-15(22)6-7-17(14)25-19(16)28)24-20-23-9-8-18(26-20)27(31(5,29)30)12-21(2,3)4/h6-11,13H,12H2,1-5H3,(H,25,28)(H,23,24,26)	PDFBGBSIUQDAET-UHFFFAOYSA-N	383718	US10280150, Cmpd No I-1::US10550099, Compound I-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383718	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383718&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995694	404853006							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766485	C[C@H](Nc1nccc(n1)N(CC1CC1)S(C)(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H22ClN5O3S/c1-12(16-10-14-9-15(21)5-6-17(14)24-19(16)27)23-20-22-8-7-18(25-20)26(30(2,28)29)11-13-3-4-13/h5-10,12-13H,3-4,11H2,1-2H3,(H,24,27)(H,22,23,25)	IIWIVYXMZOQFHZ-UHFFFAOYSA-N	383719	US10280150, Cmpd No I-2::US10550099, Compound I-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383719&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995695	404853007							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766487	C[C@H](Nc1nccc(n1)N(C1CCCOC1)S(C)(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H24ClN5O4S/c1-13(17-11-14-10-15(22)5-6-18(14)25-20(17)28)24-21-23-8-7-19(26-21)27(32(2,29)30)16-4-3-9-31-12-16/h5-8,10-11,13,16H,3-4,9,12H2,1-2H3,(H,25,28)(H,23,24,26)	OADNTPKRAPIVSV-UHFFFAOYSA-N	383720	US10280150, Cmpd No I-3::US10550099, Compound I-3	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383720	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383720&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995696	404853008							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766489	CC(C)N(c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1)S(=O)(=O)c1cccnc1 |r|	InChI=1S/C23H23ClN6O3S/c1-14(2)30(34(32,33)18-5-4-9-25-13-18)21-8-10-26-23(29-21)27-15(3)19-12-16-11-17(24)6-7-20(16)28-22(19)31/h4-15H,1-3H3,(H,28,31)(H,26,27,29)	ZGVRNACKYKKXCX-UHFFFAOYSA-N	383721	US10280150, Cmpd No I-4::US10550099, Compound I-4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383721&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995697	404853009							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766491	CC(C)CS(=O)(=O)N(C(C)C)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C22H28ClN5O3S/c1-13(2)12-32(30,31)28(14(3)4)20-8-9-24-22(27-20)25-15(5)18-11-16-10-17(23)6-7-19(16)26-21(18)29/h6-11,13-15H,12H2,1-5H3,(H,26,29)(H,24,25,27)	BNDBBKCRPAPOCQ-UHFFFAOYSA-N	383722	US10280150, Cmpd No I-5::US10550099, Compound I-5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383722	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383722&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995698	404853010							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766493	C[C@H](Nc1nccc(CN(C2CC2)S(C)(=O)=O)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H22ClN5O3S/c1-12(17-10-13-9-14(21)3-6-18(13)25-19(17)27)23-20-22-8-7-15(24-20)11-26(16-4-5-16)30(2,28)29/h3,6-10,12,16H,4-5,11H2,1-2H3,(H,25,27)(H,22,23,24)	YLFNWHPLNVDHRV-UHFFFAOYSA-N	383723	US10280150, Cmpd No I-6::US10550099, Compound I-6	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383723	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383723&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995699	404853011							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766494	C[C@H](Nc1nccc(NC(C)(C)C)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H22ClN5O/c1-11(22-18-21-8-7-16(24-18)25-19(2,3)4)14-10-12-9-13(20)5-6-15(12)23-17(14)26/h5-11H,1-4H3,(H,23,26)(H2,21,22,24,25)	WYGVSXRMOFLNOZ-UHFFFAOYSA-N	383724	US10280150, Cmpd No I-7::US10550099, Compound I-7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383724&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995700	404853012							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766496	CC(C)CN(c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1)S(C)(=O)=O |r|	InChI=1S/C20H24ClN5O3S/c1-12(2)11-26(30(4,28)29)18-7-8-22-20(25-18)23-13(3)16-10-14-9-15(21)5-6-17(14)24-19(16)27/h5-10,12-13H,11H2,1-4H3,(H,24,27)(H,22,23,25)	NOTMFFJQECVSJE-UHFFFAOYSA-N	383725	US10280150, Cmpd No I-8::US10550099, Compound I-8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383725	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383725&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995701	404853013							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766498	C[C@H](Nc1nccc(NC2CC2)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H18ClN5O/c1-10(21-18-20-7-6-16(24-18)22-13-3-4-13)14-9-11-8-12(19)2-5-15(11)23-17(14)25/h2,5-10,13H,3-4H2,1H3,(H,23,25)(H2,20,21,22,24)	RMHGQWWOWQFUKE-UHFFFAOYSA-N	383726	US10280150, Cmpd No I-9::US10550099, Compound I-9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383726	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383726&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995702	404853014							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766499	CC(C)N(c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1)S(C)(=O)=O |r|	InChI=1S/C19H22ClN5O3S/c1-11(2)25(29(4,27)28)17-7-8-21-19(24-17)22-12(3)15-10-13-9-14(20)5-6-16(13)23-18(15)26/h5-12H,1-4H3,(H,23,26)(H,21,22,24)	FJGJXQOALOTHEU-UHFFFAOYSA-N	383727	US10280150, Cmpd No I-10::US10550099, Compound I-10	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383727	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383727&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995703	404853015							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766501	CC(C)N(c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1)S(=O)(=O)CC1CC1 |r|	InChI=1S/C22H26ClN5O3S/c1-13(2)28(32(30,31)12-15-4-5-15)20-8-9-24-22(27-20)25-14(3)18-11-16-10-17(23)6-7-19(16)26-21(18)29/h6-11,13-15H,4-5,12H2,1-3H3,(H,26,29)(H,24,25,27)	MQBZFIAATYLIPQ-UHFFFAOYSA-N	383728	US10280150, Cmpd No I-11::US10550099, Compound I-11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383728	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383728&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995704	404853016							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766503	C[C@H](Nc1nccc(n1)N1CCCS1(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H18ClN5O3S/c1-11(14-10-12-9-13(19)3-4-15(12)22-17(14)25)21-18-20-6-5-16(23-18)24-7-2-8-28(24,26)27/h3-6,9-11H,2,7-8H2,1H3,(H,22,25)(H,20,21,23)	YZFVEWXCTMVFEM-UHFFFAOYSA-N	383729	US10280150, Cmpd No I-12::US10550099, Compound I-12	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383729	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383729&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995705	404853017							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766505	C[C@H](Nc1nccc(n1)N(CC(F)(F)F)S(C)(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H17ClF3N5O3S/c1-10(13-8-11-7-12(19)3-4-14(11)25-16(13)28)24-17-23-6-5-15(26-17)27(31(2,29)30)9-18(20,21)22/h3-8,10H,9H2,1-2H3,(H,25,28)(H,23,24,26)	SATIWROXFWMBFJ-UHFFFAOYSA-N	383730	US10280150, Cmpd No I-13::US10550099, Compound I-13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383730	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383730&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995706	404853018							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766506	C[C@H](Nc1nccc(n1)N(C1CC1)S(C)(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H20ClN5O3S/c1-11(15-10-12-9-13(20)3-6-16(12)23-18(15)26)22-19-21-8-7-17(24-19)25(14-4-5-14)29(2,27)28/h3,6-11,14H,4-5H2,1-2H3,(H,23,26)(H,21,22,24)	OXUYSIFHQVERHS-UHFFFAOYSA-N	383731	US10280150, Cmpd No I-14::US10550099, Compound I-14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383731	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383731&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995707	404853019							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766508	CC(C)CS(=O)(=O)N(C)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C20H24ClN5O3S/c1-12(2)11-30(28,29)26(4)18-7-8-22-20(25-18)23-13(3)16-10-14-9-15(21)5-6-17(14)24-19(16)27/h5-10,12-13H,11H2,1-4H3,(H,24,27)(H,22,23,25)	IPVIBCMFVJXIEG-UHFFFAOYSA-N	383732	US10280150, Cmpd No I-15::US10550099, Compound I-15	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383732	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383732&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995708	404853020							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766510	C[C@H](Nc1nccc(n1)N(CCC1CCOCC1)S(C)(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C23H28ClN5O4S/c1-15(19-14-17-13-18(24)3-4-20(17)27-22(19)30)26-23-25-9-5-21(28-23)29(34(2,31)32)10-6-16-7-11-33-12-8-16/h3-5,9,13-16H,6-8,10-12H2,1-2H3,(H,27,30)(H,25,26,28)	INONUJKTCMKETC-UHFFFAOYSA-N	383733	US10280150, Cmpd No I-16::US10550099, Compound I-16	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383733	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383733&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995709	404853021							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766512	C[C@H](Nc1nccc(NS(C)(=O)=O)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C16H16ClN5O3S/c1-9(19-16-18-6-5-14(21-16)22-26(2,24)25)12-8-10-7-11(17)3-4-13(10)20-15(12)23/h3-9H,1-2H3,(H,20,23)(H2,18,19,21,22)	ASOXFSNLEXATHO-UHFFFAOYSA-N	383734	US10280150, Cmpd No I-17::US10550099, Compound I-17	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383734	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383734&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995710	404853022							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766513	CC(C)CS(=O)(=O)Nc1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C19H22ClN5O3S/c1-11(2)10-29(27,28)25-17-6-7-21-19(24-17)22-12(3)15-9-13-8-14(20)4-5-16(13)23-18(15)26/h4-9,11-12H,10H2,1-3H3,(H,23,26)(H2,21,22,24,25)	MNCBNCQUHWESOH-UHFFFAOYSA-N	383735	US10280150, Cmpd No I-18::US10550099, Compound I-18	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383735	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383735&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995711	404853023							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766514	C[C@H](Nc1nccc(n1)N(CC(C)(C)O)S(C)(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H24ClN5O4S/c1-12(15-10-13-9-14(21)5-6-16(13)24-18(15)27)23-19-22-8-7-17(25-19)26(31(4,29)30)11-20(2,3)28/h5-10,12,28H,11H2,1-4H3,(H,24,27)(H,22,23,25)	APSFPJRKUFTYAQ-UHFFFAOYSA-N	383736	US10280150, Cmpd No I-19::US10550099, Compound I-19	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383736	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383736&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995712	404853024							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766515	CC(C)N(c1ccnc(NC(C)c2cc3cc(Cl)ccc3[nH]c2=O)n1)S(C)(=O)=O	InChI=1S/C19H22ClN5O3S/c1-11(2)25(29(4,27)28)17-7-8-21-19(24-17)22-12(3)15-10-13-9-14(20)5-6-16(13)23-18(15)26/h5-12H,1-4H3,(H,23,26)(H,21,22,24)	FJGJXQOALOTHEU-UHFFFAOYSA-N	383737	US10280150, Cmpd No I-20::US10550099, Compound I-20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383737	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383737&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995713	404853025							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766517	CC(C)N(c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1)S(=O)(=O)c1ccc2n(C)c(=O)oc2c1 |r|	InChI=1S/C26H25ClN6O5S/c1-14(2)33(39(36,37)18-6-8-21-22(13-18)38-26(35)32(21)4)23-9-10-28-25(31-23)29-15(3)19-12-16-11-17(27)5-7-20(16)30-24(19)34/h5-15H,1-4H3,(H,30,34)(H,28,29,31)	SENWNZCXZNKJRA-UHFFFAOYSA-N	383738	US10280150, Cmpd No I-21::US10550099, Compound I-21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383738	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383738&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995714	404853026							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766519	COC(=O)Nc1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C17H16ClN5O3/c1-9(20-16-19-6-5-14(22-16)23-17(25)26-2)12-8-10-7-11(18)3-4-13(10)21-15(12)24/h3-9H,1-2H3,(H,21,24)(H2,19,20,22,23,25)	WFKGXYJYRVHFRO-UHFFFAOYSA-N	383739	US10280150, Cmpd No I-22::US10550099, Compound I-22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383739	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383739&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995715	404853027							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766521	CC(C)OC(=O)Nc1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C19H20ClN5O3/c1-10(2)28-19(27)25-16-6-7-21-18(24-16)22-11(3)14-9-12-8-13(20)4-5-15(12)23-17(14)26/h4-11H,1-3H3,(H,23,26)(H2,21,22,24,25,27)	ZNGWFRSYFIBVPY-UHFFFAOYSA-N	383740	US10280150, Cmpd No I-23::US10550099, Compound I-23	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383740	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383740&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995716	404853028							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766522	CC(C)CC(=O)N(C1CC1)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C23H26ClN5O2/c1-13(2)10-21(30)29(17-5-6-17)20-8-9-25-23(28-20)26-14(3)18-12-15-11-16(24)4-7-19(15)27-22(18)31/h4,7-9,11-14,17H,5-6,10H2,1-3H3,(H,27,31)(H,25,26,28)	XCCJYYPEZGSTIK-UHFFFAOYSA-N	383741	US10280150, Cmpd No I-24::US10550099, Compound I-24	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383741	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383741&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995717	404853029							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766523	C[C@H](Nc1nccc(NC(C)=O)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C17H16ClN5O2/c1-9(20-17-19-6-5-15(23-17)21-10(2)24)13-8-11-7-12(18)3-4-14(11)22-16(13)25/h3-9H,1-2H3,(H,22,25)(H2,19,20,21,23,24)	OGHZJOVLWKGTPM-UHFFFAOYSA-N	383742	US10280150, Cmpd No I-25::US10550099, Compound I-25	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383742	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383742&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995718	404853030							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766525	C[C@H](Nc1nccc(n1)N(CC(C)(C)C)C(C)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C22H26ClN5O2/c1-13(17-11-15-10-16(23)6-7-18(15)26-20(17)30)25-21-24-9-8-19(27-21)28(14(2)29)12-22(3,4)5/h6-11,13H,12H2,1-5H3,(H,26,30)(H,24,25,27)	ZDZPCYARNPIWQW-UHFFFAOYSA-N	383743	US10280150, Cmpd No I-26::US10550099, Compound I-26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383743	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383743&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995719	404853031							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766526	C[C@H](Nc1nccc(NC(=O)CC2CCOCC2)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C22H24ClN5O3/c1-13(17-12-15-11-16(23)2-3-18(15)26-21(17)30)25-22-24-7-4-19(28-22)27-20(29)10-14-5-8-31-9-6-14/h2-4,7,11-14H,5-6,8-10H2,1H3,(H,26,30)(H2,24,25,27,28,29)	YBCKHPJUAPVTBO-UHFFFAOYSA-N	383744	US10280150, Cmpd No I-27::US10550099, Compound I-27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383744	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383744&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995720	404853032							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766527	C[C@H](Nc1nccc(n1)N(C1CC1)C(C)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H20ClN5O2/c1-11(16-10-13-9-14(21)3-6-17(13)24-19(16)28)23-20-22-8-7-18(25-20)26(12(2)27)15-4-5-15/h3,6-11,15H,4-5H2,1-2H3,(H,24,28)(H,22,23,25)	TWHAHXQUFUFEGE-UHFFFAOYSA-N	383745	US10280150, Cmpd No I-28::US10550099, Compound I-28	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383745	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383745&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995721	404853033							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766528	C[C@H](Nc1nccc(NC(=O)C2CC2)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H18ClN5O2/c1-10(14-9-12-8-13(20)4-5-15(12)23-18(14)27)22-19-21-7-6-16(25-19)24-17(26)11-2-3-11/h4-11H,2-3H2,1H3,(H,23,27)(H2,21,22,24,25,26)	AQMZRUZRHGBAJE-UHFFFAOYSA-N	383746	US10280150, Cmpd No I-29::US10550099, Compound I-29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383746	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383746&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995722	404853034							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766530	C[C@H](Nc1nccc(n1)N(C(C)=O)C(C)(C)C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H24ClN5O2/c1-12(16-11-14-10-15(22)6-7-17(14)25-19(16)29)24-20-23-9-8-18(26-20)27(13(2)28)21(3,4)5/h6-12H,1-5H3,(H,25,29)(H,23,24,26)	FLCFKDPIBYBGHN-UHFFFAOYSA-N	383747	US10280150, Cmpd No I-30::US10550099, Compound I-30	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383747	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383747&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995723	404853035							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766531	CC(C)CC(=O)Nc1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C20H22ClN5O2/c1-11(2)8-18(27)25-17-6-7-22-20(26-17)23-12(3)15-10-13-9-14(21)4-5-16(13)24-19(15)28/h4-7,9-12H,8H2,1-3H3,(H,24,28)(H2,22,23,25,26,27)	AMFFOFXKSOTTIB-UHFFFAOYSA-N	383748	US10280150, Cmpd No I-31::US10550099, Compound I-31	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383748	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383748&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995724	404853036							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766532	COCC(=O)Nc1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C18H18ClN5O3/c1-10(13-8-11-7-12(19)3-4-14(11)22-17(13)26)21-18-20-6-5-15(24-18)23-16(25)9-27-2/h3-8,10H,9H2,1-2H3,(H,22,26)(H2,20,21,23,24,25)	ZRXVKOAMFKLZGD-UHFFFAOYSA-N	383749	US10280150, Cmpd No I-32::US10550099, Compound I-32	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383749	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383749&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995725	404853037							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766533	CCC(=O)Nc1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C18H18ClN5O2/c1-3-16(25)23-15-6-7-20-18(24-15)21-10(2)13-9-11-8-12(19)4-5-14(11)22-17(13)26/h4-10H,3H2,1-2H3,(H,22,26)(H2,20,21,23,24,25)	YEDPTPNOJUHFGL-UHFFFAOYSA-N	383750	US10280150, Cmpd No I-33::US10550099, Compound I-33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383750	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383750&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995726	404853038							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766535	CC(C)CN(C(C)=O)c1ccnc(NC(C)c2cc3cc(Cl)ccc3[nH]c2=O)n1	InChI=1S/C21H24ClN5O2/c1-12(2)11-27(14(4)28)19-7-8-23-21(26-19)24-13(3)17-10-15-9-16(22)5-6-18(15)25-20(17)29/h5-10,12-13H,11H2,1-4H3,(H,25,29)(H,23,24,26)	KGOSRIQPZDPXNS-UHFFFAOYSA-N	383751	US10280150, Cmpd No I-34::US10550099, Compound I-34	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383751	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383751&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995727	404853039							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766536	CC(C)CN(C(=O)C1CC1)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C23H26ClN5O2/c1-13(2)12-29(22(31)15-4-5-15)20-8-9-25-23(28-20)26-14(3)18-11-16-10-17(24)6-7-19(16)27-21(18)30/h6-11,13-15H,4-5,12H2,1-3H3,(H,27,30)(H,25,26,28)	XACNPBWTCUHCQL-UHFFFAOYSA-N	383752	US10280150, Cmpd No I-35::US10550099, Compound I-35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383752	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383752&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995728	404853040							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766538	COc1nc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C17H14ClN5O2/c1-9(21-17-20-8-11(7-19)16(23-17)25-2)13-6-10-5-12(18)3-4-14(10)22-15(13)24/h3-6,8-9H,1-2H3,(H,22,24)(H,20,21,23)	QAFWVLDKBWIXLX-UHFFFAOYSA-N	383753	US10280150, Cmpd No I-36::US10550099, Compound I-156	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383753	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383753&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995729	404853041							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766540	C[C@H](Nc1ncc(C#N)c(N)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C16H13ClN6O/c1-8(21-16-20-7-10(6-18)14(19)23-16)12-5-9-4-11(17)2-3-13(9)22-15(12)24/h2-5,7-8H,1H3,(H,22,24)(H3,19,20,21,23)	NEMZJLWUVYTNQK-UHFFFAOYSA-N	383754	US10280150, Cmpd No I-37::US10550099, Compound I-37	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383754	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383754&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995730	404853042							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766541	CNc1nc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C17H15ClN6O/c1-9(22-17-21-8-11(7-19)15(20-2)24-17)13-6-10-5-12(18)3-4-14(10)23-16(13)25/h3-6,8-9H,1-2H3,(H,23,25)(H2,20,21,22,24)	JZPKYJWBXABXSU-UHFFFAOYSA-N	383755	US10280150, Cmpd No I-38::US10550099, Compound I-38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383755	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383755&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995731	404853043							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766543	C[C@H](Nc1ncc(C#N)c(C)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C17H14ClN5O/c1-9-12(7-19)8-20-17(21-9)22-10(2)14-6-11-5-13(18)3-4-15(11)23-16(14)24/h3-6,8,10H,1-2H3,(H,23,24)(H,20,21,22)	DXHZNUXMBDALDX-UHFFFAOYSA-N	383756	US10280150, Cmpd No I-39::US10550099, Compound I-39	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383756	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383756&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995732	404853044							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766545	C[C@H](Nc1ncc(C#N)c(n1)C1CC1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H16ClN5O/c1-10(15-7-12-6-14(20)4-5-16(12)24-18(15)26)23-19-22-9-13(8-21)17(25-19)11-2-3-11/h4-7,9-11H,2-3H2,1H3,(H,24,26)(H,22,23,25)	ZJAJAEHHCPYUEU-UHFFFAOYSA-N	383757	US10280150, Cmpd No I-40::US10550099, Compound I-40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383757	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383757&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995733	404853045							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766546	COc1nc(N[C@@H](C)c2cc3cc(Cl)ccc3n(C)c2=O)ncc1C#N |r|	InChI=1S/C18H16ClN5O2/c1-10(22-18-21-9-12(8-20)16(23-18)26-3)14-7-11-6-13(19)4-5-15(11)24(2)17(14)25/h4-7,9-10H,1-3H3,(H,21,22,23)	RDWBYCLMYSKOTA-UHFFFAOYSA-N	383758	US10280150, Cmpd No I-41::US10550099, Compound I-41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383758	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383758&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118953994	404853046							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766548	CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C21H22ClN5O3/c1-11(2)17-10-30-21(29)27(17)18-6-7-23-20(26-18)24-12(3)15-9-13-8-14(22)4-5-16(13)25-19(15)28/h4-9,11-12,17H,10H2,1-3H3,(H,25,28)(H,23,24,26)	BQXMMSHPKZRVGT-UHFFFAOYSA-N	383759	US10280150, Cmpd No I-42::US10550099, Compound I-42	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383759	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383759&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995734	404853047							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766550	CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C21H22ClN5O3/c1-11(2)17-10-30-21(29)27(17)18-6-7-23-20(26-18)24-12(3)15-9-13-8-14(22)4-5-16(13)25-19(15)28/h4-9,11-12,17H,10H2,1-3H3,(H,25,28)(H,23,24,26)	BQXMMSHPKZRVGT-UHFFFAOYSA-N	383760	US10280150, Cmpd No I-43::US10550099, Compound I-43	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383760	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383760&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995735	404853048							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766551	C[C@H](Nc1nccc(n1)N1CCOC1=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H16ClN5O3/c1-10(13-9-11-8-12(19)2-3-14(11)22-16(13)25)21-17-20-5-4-15(23-17)24-6-7-27-18(24)26/h2-5,8-10H,6-7H2,1H3,(H,22,25)(H,20,21,23)	BTUGZKWGQKVBMC-UHFFFAOYSA-N	383761	US10280150, Cmpd No I-44::US10550099, Compound I-44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383761	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383761&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995736	404853049							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766553	C[C@@H](Nc1nccc(n1)N1CCOC1=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H16ClN5O3/c1-10(13-9-11-8-12(19)2-3-14(11)22-16(13)25)21-17-20-5-4-15(23-17)24-6-7-27-18(24)26/h2-5,8-10H,6-7H2,1H3,(H,22,25)(H,20,21,23)	BTUGZKWGQKVBMC-UHFFFAOYSA-N	383762	US10280150, Cmpd No I-45::US10550099, Compound I-45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383762	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383762&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995737	404853050							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766555	CC(C)[C@H]1COC(=O)N1c1ccnc(NCc2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C20H20ClN5O3/c1-11(2)16-10-29-20(28)26(16)17-5-6-22-19(25-17)23-9-13-7-12-8-14(21)3-4-15(12)24-18(13)27/h3-8,11,16H,9-10H2,1-2H3,(H,24,27)(H,22,23,25)	SZSVFGOEMYLUNB-UHFFFAOYSA-N	383763	US10280150, Cmpd No I-46::US10550099, Compound I-46	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383763	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383763&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995738	404853051							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766557	Clc1ccc2[nH]c(=O)c(CNc3nccc(n3)N3CCOC3=O)cc2c1	InChI=1S/C17H14ClN5O3/c18-12-1-2-13-10(8-12)7-11(15(24)21-13)9-20-16-19-4-3-14(22-16)23-5-6-26-17(23)25/h1-4,7-8H,5-6,9H2,(H,21,24)(H,19,20,22)	OIYBWFJBTGLWGE-UHFFFAOYSA-N	383764	US10280150, Cmpd No I-47::US10550099, Compound I-47	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383764	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383764&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995739	404853052							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766559	CC(Nc1nccc(n1)N1CCOC1=O)c1cc2cc(Cl)ccc2[nH]c1=O	InChI=1S/C18H16ClN5O3/c1-10(13-9-11-8-12(19)2-3-14(11)22-16(13)25)21-17-20-5-4-15(23-17)24-6-7-27-18(24)26/h2-5,8-10H,6-7H2,1H3,(H,22,25)(H,20,21,23)	BTUGZKWGQKVBMC-UHFFFAOYSA-N	383765	US10280150, Cmpd No I-48::US10550099, Compound I-48	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383765	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383765&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995740	404853053							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766561	CC(Nc1nccc(n1)N1CCOC1=O)c1cc2ccccc2[nH]c1=O	InChI=1S/C18H17N5O3/c1-11(13-10-12-4-2-3-5-14(12)21-16(13)24)20-17-19-7-6-15(22-17)23-8-9-26-18(23)25/h2-7,10-11H,8-9H2,1H3,(H,21,24)(H,19,20,22)	QISNNNDUSHBCMM-UHFFFAOYSA-N	383766	US10280150, Cmpd No I-49::US10550099, Compound I-49	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383766	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383766&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995741	404853054							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766562	Clc1ccc2[nH]c(=O)c(CNc3nccc(n3)N3CCCC3=O)cc2c1	InChI=1S/C18H16ClN5O2/c19-13-3-4-14-11(9-13)8-12(17(26)22-14)10-21-18-20-6-5-15(23-18)24-7-1-2-16(24)25/h3-6,8-9H,1-2,7,10H2,(H,22,26)(H,20,21,23)	MNWVSOPPEGSRHQ-UHFFFAOYSA-N	383767	US10280150, Cmpd No I-50::US10550099, Compound I-50	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383767	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383767&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995742	404853055							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766563	C[C@H](Nc1nccc(n1)-n1cccc1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H18ClN5O/c1-12-4-3-9-26(12)18-7-8-22-20(25-18)23-13(2)16-11-14-10-15(21)5-6-17(14)24-19(16)27/h3-11,13H,1-2H3,(H,24,27)(H,22,23,25)	PGMTZTOWMIVRIA-UHFFFAOYSA-N	383768	US10280150, Cmpd No I-51::US10550099, Compound I-51	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383768	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383768&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995743	404853056							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766565	C[C@H](Nc1nccc(n1)-n1cccc1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H16ClN5O/c1-12(15-11-13-10-14(20)4-5-16(13)23-18(15)26)22-19-21-7-6-17(24-19)25-8-2-3-9-25/h2-12H,1H3,(H,23,26)(H,21,22,24)	RCAKTXKRSUDKFP-UHFFFAOYSA-N	383769	US10280150, Cmpd No I-52::US10550099, Compound I-52	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383769	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383769&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995744	404853057							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766566	C[C@H](Nc1nccc(n1)-n1ccc(C)c1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H20ClN5O/c1-12-7-9-27(14(12)3)19-6-8-23-21(26-19)24-13(2)17-11-15-10-16(22)4-5-18(15)25-20(17)28/h4-11,13H,1-3H3,(H,25,28)(H,23,24,26)	NMIJSGJNBVUKQN-UHFFFAOYSA-N	383770	US10280150, Cmpd No I-53	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383770	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383770&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995745	404853058							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766567	C[C@H](Nc1nccc(n1)-n1ccnc1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H15ClN6O/c1-11(14-9-12-8-13(19)2-3-15(12)23-17(14)26)22-18-21-5-4-16(24-18)25-7-6-20-10-25/h2-11H,1H3,(H,23,26)(H,21,22,24)	GJIKDXWHVDVKFX-UHFFFAOYSA-N	383771	US10280150, Cmpd No I-54::US10550099, Compound I-54	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383771	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383771&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995746	404853059							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766569	C[C@H](Nc1nccc(n1)-n1cnc2CCCc12)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H19ClN6O/c1-12(15-10-13-9-14(22)5-6-16(13)26-20(15)29)25-21-23-8-7-19(27-21)28-11-24-17-3-2-4-18(17)28/h5-12H,2-4H2,1H3,(H,26,29)(H,23,25,27)	RYTFFDAXPNHRFO-UHFFFAOYSA-N	383772	US10280150, Cmpd No I-55::US10550099, Compound I-55	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383772	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383772&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995747	404853060							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766571	C[C@H](Nc1nccc(n1)-n1ccnc1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H17ClN6O/c1-11(15-10-13-9-14(20)3-4-16(13)24-18(15)27)23-19-22-6-5-17(25-19)26-8-7-21-12(26)2/h3-11H,1-2H3,(H,24,27)(H,22,23,25)	XEOVOVCWVRXTGF-UHFFFAOYSA-N	383773	US10280150, Cmpd No I-56::US10550099, Compound I-56	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383773	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383773&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995748	404853061							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766572	C[C@H](Nc1nccc(n1)-n1cnc(C)c1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H17ClN6O/c1-11-9-26(10-22-11)17-5-6-21-19(25-17)23-12(2)15-8-13-7-14(20)3-4-16(13)24-18(15)27/h3-10,12H,1-2H3,(H,24,27)(H,21,23,25)	QTFAQBRIBOJJMQ-UHFFFAOYSA-N	383774	US10280150, Cmpd No I-57::US10550099, Compound I-57	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383774	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383774&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995749	404853062							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766573	C[C@H](Nc1nccc(n1)-c1cnoc1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H16ClN5O2/c1-10(14-8-12-7-13(20)3-4-16(12)24-18(14)26)23-19-21-6-5-17(25-19)15-9-22-27-11(15)2/h3-10H,1-2H3,(H,24,26)(H,21,23,25)	DSURWNHICLZAIP-UHFFFAOYSA-N	383775	US10280150, Cmpd No I-58::US10550099, Compound I-58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383775	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383775&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995750	404853063							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766575	C[C@H](Nc1nccc(n1)-n1nnnc1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C17H15ClN8O/c1-9(13-8-11-7-12(18)3-4-14(11)21-16(13)27)20-17-19-6-5-15(22-17)26-10(2)23-24-25-26/h3-9H,1-2H3,(H,21,27)(H,19,20,22)	UQLHGCXSQUULQE-UHFFFAOYSA-N	383776	US10280150, Cmpd No I-59::US10550099, Compound I-59	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383776	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383776&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995751	404853064							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766577	C[C@H](Nc1nccc(n1)-c1cncn1CC(F)(F)F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H16ClF3N6O/c1-11(14-7-12-6-13(21)2-3-15(12)28-18(14)31)27-19-26-5-4-16(29-19)17-8-25-10-30(17)9-20(22,23)24/h2-8,10-11H,9H2,1H3,(H,28,31)(H,26,27,29)	RITFQEXZBNEGCD-UHFFFAOYSA-N	383777	US10280150, Cmpd No I-60::US10550099, Compound I-60	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383777&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995752	404853065							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766579	C[C@H](Nc1nccc(n1)-c1cncn1CC1CC1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C22H21ClN6O/c1-13(17-9-15-8-16(23)4-5-18(15)27-21(17)30)26-22-25-7-6-19(28-22)20-10-24-12-29(20)11-14-2-3-14/h4-10,12-14H,2-3,11H2,1H3,(H,27,30)(H,25,26,28)	IOTAWKJXNJPMAB-UHFFFAOYSA-N	383778	US10280150, Cmpd No I-61::US10550099, Compound I-61	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383778&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995753	404853066							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766581	C[C@H](Nc1nccc(n1)-c1cncnc1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H15ClN6O/c1-11(15-7-12-6-14(20)2-3-16(12)25-18(15)27)24-19-23-5-4-17(26-19)13-8-21-10-22-9-13/h2-11H,1H3,(H,25,27)(H,23,24,26)	ZRWNUHGHYONKGF-UHFFFAOYSA-N	383779	US10280150, Cmpd No I-62::US10550099, Compound I-62	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383779&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995754	404853067							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766582	C[C@H](Nc1nccc(n1)-c1cnc2ccccn12)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C22H17ClN6O/c1-13(16-11-14-10-15(23)5-6-17(14)27-21(16)30)26-22-24-8-7-18(28-22)19-12-25-20-4-2-3-9-29(19)20/h2-13H,1H3,(H,27,30)(H,24,26,28)	JUNGABYWISKKML-UHFFFAOYSA-N	383780	US10280150, Cmpd No I-63::US10550099, Compound I-63	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383780	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383780&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995755	404853068							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766584	CC(C)n1cncc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C21H21ClN6O/c1-12(2)28-11-23-10-19(28)18-6-7-24-21(27-18)25-13(3)16-9-14-8-15(22)4-5-17(14)26-20(16)29/h4-13H,1-3H3,(H,26,29)(H,24,25,27)	HWGQNIBDVMLHMH-UHFFFAOYSA-N	383781	US10280150, Cmpd No I-64::US10550099, Compound I-64	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383781	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383781&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995756	404853069							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766586	C[C@H](Nc1nccc(n1)-n1cccc1C(F)(F)F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H15ClF3N5O/c1-11(14-10-12-9-13(21)4-5-15(12)27-18(14)30)26-19-25-7-6-17(28-19)29-8-2-3-16(29)20(22,23)24/h2-11H,1H3,(H,27,30)(H,25,26,28)	IZNMTAUTDFMJRY-UHFFFAOYSA-N	383782	US10280150, Cmpd No I-65::US10550099, Compound I-65	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383782&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995757	404853070							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766588	C[C@H](Nc1nccc(n1)-c1cnnn1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H16ClN7O/c1-10(13-8-11-7-12(19)3-4-14(11)23-17(13)27)22-18-20-6-5-15(24-18)16-9-21-25-26(16)2/h3-10H,1-2H3,(H,23,27)(H,20,22,24)	QEYLVOXRLADSDJ-UHFFFAOYSA-N	383783	US10280150, Cmpd No I-66::US10550099, Compound I-66	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383783	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383783&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995758	404853071							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766590	C[C@H](Nc1nccc(n1)-c1ccnn1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H17ClN6O/c1-11(14-10-12-9-13(20)3-4-15(12)24-18(14)27)23-19-21-7-5-16(25-19)17-6-8-22-26(17)2/h3-11H,1-2H3,(H,24,27)(H,21,23,25)	ALWQYWZOPFMKAR-UHFFFAOYSA-N	383784	US10280150, Cmpd No I-67::US10550099, Compound I-67	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383784&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995759	404853072							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766591	C[C@H](Nc1nccc(n1)-c1cncn1Cc1ccccc1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C25H21ClN6O/c1-16(20-12-18-11-19(26)7-8-21(18)30-24(20)33)29-25-28-10-9-22(31-25)23-13-27-15-32(23)14-17-5-3-2-4-6-17/h2-13,15-16H,14H2,1H3,(H,30,33)(H,28,29,31)	YTLMNLSWKINCGV-UHFFFAOYSA-N	383785	US10280150, Cmpd No I-68::US10550099, Compound I-68	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383785&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995760	404853073							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766593	C[C@H](Nc1nccc(n1)-c1c(C)noc1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H18ClN5O2/c1-10(15-9-13-8-14(21)4-5-16(13)24-19(15)27)23-20-22-7-6-17(25-20)18-11(2)26-28-12(18)3/h4-10H,1-3H3,(H,24,27)(H,22,23,25)	VHJSUWPTLLTSJD-UHFFFAOYSA-N	383786	US10280150, Cmpd No I-69::US10550099, Compound I-69	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383786&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995761	404853074							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766594	C[C@H](Nc1nccc(n1)-c1cnoc1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H14ClN5O2/c1-10(14-7-11-6-13(19)2-3-15(11)23-17(14)25)22-18-20-5-4-16(24-18)12-8-21-26-9-12/h2-10H,1H3,(H,23,25)(H,20,22,24)	VDCOZBZKOJRUFF-UHFFFAOYSA-N	383787	US10280150, Cmpd No I-70::US10550099, Compound I-70	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383787	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383787&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995762	404853075							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766595	C[C@H](Nc1nccc(n1)-c1cncn1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H17ClN6O/c1-11(14-8-12-7-13(20)3-4-15(12)24-18(14)27)23-19-22-6-5-16(25-19)17-9-21-10-26(17)2/h3-11H,1-2H3,(H,24,27)(H,22,23,25)	WPESHFWYUVZQEM-UHFFFAOYSA-N	383788	US10280150, Cmpd No I-71::US10550099, Compound I-71	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383788	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383788&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995763	404853076							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766597	C[C@H](Nc1nccc(n1)-c1ccccc1C(C)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C23H19ClN4O2/c1-13(19-12-15-11-16(24)7-8-20(15)27-22(19)30)26-23-25-10-9-21(28-23)18-6-4-3-5-17(18)14(2)29/h3-13H,1-2H3,(H,27,30)(H,25,26,28)	FEELFQNDKHPUJK-UHFFFAOYSA-N	383789	US10280150, Cmpd No I-72::US10550099, Compound I-72	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383789&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995764	404853077							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766598	C[C@H](Nc1nccc(n1)-c1ccccc1NC(C)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C23H20ClN5O2/c1-13(18-12-15-11-16(24)7-8-19(15)28-22(18)31)26-23-25-10-9-21(29-23)17-5-3-4-6-20(17)27-14(2)30/h3-13H,1-2H3,(H,27,30)(H,28,31)(H,25,26,29)	PHVOYEWNQOXSED-UHFFFAOYSA-N	383790	US10280150, Cmpd No I-73::US10550099, Compound I-73	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383790	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383790&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995765	404853078							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766599	C[C@H](Nc1nccc(n1)-c1cnn(C)c1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H19ClN6O/c1-11(15-9-13-8-14(21)4-5-17(13)25-19(15)28)24-20-22-7-6-18(26-20)16-10-23-27(3)12(16)2/h4-11H,1-3H3,(H,25,28)(H,22,24,26)	LLNMBEWJQHUHGA-UHFFFAOYSA-N	383791	US10280150, Cmpd No I-74::US10550099, Compound I-74	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383791&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995766	404853079							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766600	CC(C)n1nccc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C21H21ClN6O/c1-12(2)28-19(7-9-24-28)18-6-8-23-21(27-18)25-13(3)16-11-14-10-15(22)4-5-17(14)26-20(16)29/h4-13H,1-3H3,(H,26,29)(H,23,25,27)	KHPDQJGUDAOSNG-UHFFFAOYSA-N	383792	US10280150, Cmpd No I-75::US10550099, Compound I-75	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383792&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995767	404853080							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766602	C[C@H](Nc1nccc(n1)-c1cc(C)nn1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H19ClN6O/c1-11-8-18(27(3)26-11)17-6-7-22-20(25-17)23-12(2)15-10-13-9-14(21)4-5-16(13)24-19(15)28/h4-10,12H,1-3H3,(H,24,28)(H,22,23,25)	IWAATPANYZNHKP-UHFFFAOYSA-N	383793	US10280150, Cmpd No I-76::US10550099, Compound I-76	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383793&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995768	404853081							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766603	C[C@H](Nc1nccc(n1)-c1cn(C)nc1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H19ClN6O/c1-11(15-9-13-8-14(21)4-5-17(13)24-19(15)28)23-20-22-7-6-18(25-20)16-10-27(3)26-12(16)2/h4-11H,1-3H3,(H,24,28)(H,22,23,25)	PLNUXWPYRKYBIB-UHFFFAOYSA-N	383794	US10280150, Cmpd No I-77::US10550099, Compound I-77	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383794&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995769	404853082							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766604	C[C@H](Nc1nccc(n1)-c1sc(C)nc1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H18ClN5OS/c1-10(15-9-13-8-14(21)4-5-16(13)25-19(15)27)24-20-22-7-6-17(26-20)18-11(2)23-12(3)28-18/h4-10H,1-3H3,(H,25,27)(H,22,24,26)	DADNXLIDJIKLJY-UHFFFAOYSA-N	383795	US10280150, Cmpd No I-78::US10550099, Compound I-78	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383795	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383795&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995770	404853083							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766605	C[C@H](Nc1nccc(n1)-c1ccnn1C1CCCCO1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C23H23ClN6O2/c1-14(17-13-15-12-16(24)5-6-18(15)28-22(17)31)27-23-25-9-7-19(29-23)20-8-10-26-30(20)21-4-2-3-11-32-21/h5-10,12-14,21H,2-4,11H2,1H3,(H,28,31)(H,25,27,29)	CVGBSEFGNDJRSG-UHFFFAOYSA-N	383796	US10280150, Cmpd No I-79::US10550099, Compound I-79	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383796&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995771	404853084							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766606	C[C@H](Nc1nccc(n1)-c1cscc1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H17ClN4OS/c1-11-9-27-10-16(11)18-5-6-22-20(25-18)23-12(2)15-8-13-7-14(21)3-4-17(13)24-19(15)26/h3-10,12H,1-2H3,(H,24,26)(H,22,23,25)	JFQRIMUYIHPEOG-UHFFFAOYSA-N	383797	US10280150, Cmpd No I-80::US10550099, Compound I-80	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383797&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995772	404853085							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766607	C[C@H](Nc1nccc(n1)-c1cccn1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H18ClN5O/c1-12(15-11-13-10-14(21)5-6-16(13)24-19(15)27)23-20-22-8-7-17(25-20)18-4-3-9-26(18)2/h3-12H,1-2H3,(H,24,27)(H,22,23,25)	GGZBTUCPNYMIOW-UHFFFAOYSA-N	383798	US10280150, Cmpd No I-81::US10550099, Compound I-81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383798&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995773	404853086							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766608	C[C@H](Nc1nccc(n1)-c1c(C)n[nH]c1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H19ClN6O/c1-10(15-9-13-8-14(21)4-5-16(13)24-19(15)28)23-20-22-7-6-17(25-20)18-11(2)26-27-12(18)3/h4-10H,1-3H3,(H,24,28)(H,26,27)(H,22,23,25)	XXHBAQZGFDZZAX-UHFFFAOYSA-N	383799	US10280150, Cmpd No I-83::US10280150, Cmpd No I-82::US10550099, Compound I-82	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383799&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995774	404853087							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766609	C[C@H](Nc1nccc(n1)-c1c(C)n[nH]c1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H19ClN6O/c1-10(15-9-13-8-14(21)4-5-16(13)24-19(15)28)23-20-22-7-6-17(25-20)18-11(2)26-27-12(18)3/h4-10H,1-3H3,(H,24,28)(H,26,27)(H,22,23,25)	XXHBAQZGFDZZAX-UHFFFAOYSA-N	383799	US10280150, Cmpd No I-83::US10280150, Cmpd No I-82::US10550099, Compound I-82	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383799&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995774	404853087							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766611	C[C@H](Nc1nccc(n1)-c1c(C)nn(C)c1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H21ClN6O/c1-11(16-10-14-9-15(22)5-6-17(14)25-20(16)29)24-21-23-8-7-18(26-21)19-12(2)27-28(4)13(19)3/h5-11H,1-4H3,(H,25,29)(H,23,24,26)	UPUDSDPBPRCMSD-UHFFFAOYSA-N	383801	US10280150, Cmpd No I-84::US10550099, Compound I-84	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383801	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383801&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995775	404853088							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766613	CC(C)Cn1cncc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C22H23ClN6O/c1-13(2)11-29-12-24-10-20(29)19-6-7-25-22(28-19)26-14(3)17-9-15-8-16(23)4-5-18(15)27-21(17)30/h4-10,12-14H,11H2,1-3H3,(H,27,30)(H,25,26,28)	BFPIOQFECNSTLW-UHFFFAOYSA-N	383802	US10280150, Cmpd No I-85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383802&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995776	404853089							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766615	C[C@H](Nc1nccc(n1)-c1c[nH]nc1C(F)(F)F)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H14ClF3N6O/c1-9(12-7-10-6-11(20)2-3-14(10)27-17(12)30)26-18-24-5-4-15(28-18)13-8-25-29-16(13)19(21,22)23/h2-9H,1H3,(H,25,29)(H,27,30)(H,24,26,28)	SEFIIHBUPFEWHO-UHFFFAOYSA-N	383803	US10280150, Cmpd No I-86::US10550099, Compound I-86	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383803&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995777	404853090							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766617	C[C@H](Nc1nccc(n1)-c1ccn[nH]1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H15ClN6O/c1-10(13-9-11-8-12(19)2-3-14(11)23-17(13)26)22-18-20-6-4-15(24-18)16-5-7-21-25-16/h2-10H,1H3,(H,21,25)(H,23,26)(H,20,22,24)	ICCUSBSYAZIVDA-UHFFFAOYSA-N	383804	US10280150, Cmpd No I-87::US10550099, Compound I-87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383804	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383804&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995778	404853091							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766619	C[C@H](Nc1nccc(n1)-c1cnsc1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H14ClN5OS/c1-10(14-7-11-6-13(19)2-3-15(11)23-17(14)25)22-18-20-5-4-16(24-18)12-8-21-26-9-12/h2-10H,1H3,(H,23,25)(H,20,22,24)	ALRYUKWZACFZIB-UHFFFAOYSA-N	383805	US10280150, Cmpd No I-88::US10550099, Compound I-88	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383805&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995779	404853092							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766621	C[C@H](Nc1nccc(n1)-c1coc2ccccc12)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C23H17ClN4O2/c1-13(17-11-14-10-15(24)6-7-19(14)27-22(17)29)26-23-25-9-8-20(28-23)18-12-30-21-5-3-2-4-16(18)21/h2-13H,1H3,(H,27,29)(H,25,26,28)	SLOUHCLWWONKML-UHFFFAOYSA-N	383806	US10280150, Cmpd No I-89::US10550099, Compound I-89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383806&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995780	404853093							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766623	C[C@H](Nc1nccc(n1)-c1cccnc1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H18ClN5O/c1-12-16(4-3-8-23-12)19-7-9-24-21(27-19)25-13(2)17-11-14-10-15(22)5-6-18(14)26-20(17)28/h3-11,13H,1-2H3,(H,26,28)(H,24,25,27)	CPRSIVWOBJQJED-UHFFFAOYSA-N	383807	US10280150, Cmpd No I-90::US10550099, Compound I-90	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383807&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995781	404853094							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766625	C[C@H](Nc1nccc(n1)-c1cnn(C)c1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H17ClN6O/c1-11(15-8-12-7-14(20)3-4-16(12)24-18(15)27)23-19-21-6-5-17(25-19)13-9-22-26(2)10-13/h3-11H,1-2H3,(H,24,27)(H,21,23,25)	WCAKGWWDSJGJHN-UHFFFAOYSA-N	383808	US10280150, Cmpd No I-91::US10550099, Compound I-91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383808&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995782	404853095							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766627	C[C@H](Nc1nccc(n1)-c1cncc2ccccc12)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C24H18ClN5O/c1-14(19-11-16-10-17(25)6-7-21(16)29-23(19)31)28-24-27-9-8-22(30-24)20-13-26-12-15-4-2-3-5-18(15)20/h2-14H,1H3,(H,29,31)(H,27,28,30)	KOIYDCSLTBXMQB-UHFFFAOYSA-N	383809	US10280150, Cmpd No I-92::US10550099, Compound I-92	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383809&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995783	404853096							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766629	COc1ncccc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C21H18ClN5O2/c1-12(16-11-13-10-14(22)5-6-17(13)26-19(16)28)25-21-24-9-7-18(27-21)15-4-3-8-23-20(15)29-2/h3-12H,1-2H3,(H,26,28)(H,24,25,27)	LHOKHOKFHMHHHC-UHFFFAOYSA-N	383810	US10280150, Cmpd No I-93::US10550099, Compound I-93	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383810&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995784	404853097							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766631	C[C@H](Nc1nccc(n1)-c1cccnc1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H16ClN5O/c1-12(16-10-14-9-15(21)4-5-17(14)25-19(16)27)24-20-23-8-6-18(26-20)13-3-2-7-22-11-13/h2-12H,1H3,(H,25,27)(H,23,24,26)	DINSQHUXUISIEQ-UHFFFAOYSA-N	383811	US10280150, Cmpd No I-94::US10550099, Compound I-94	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383811&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995785	404853098							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766633	C[C@H](Nc1nccc(n1)-c1ccncc1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H16ClN5O/c1-12(16-11-14-10-15(21)2-3-17(14)25-19(16)27)24-20-23-9-6-18(26-20)13-4-7-22-8-5-13/h2-12H,1H3,(H,25,27)(H,23,24,26)	ZLBMDLHBQDZAOY-UHFFFAOYSA-N	383812	US10280150, Cmpd No I-95::US10550099, Compound I-95	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383812&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995786	404853099							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766635	C[C@H](Nc1nccc(n1)-c1ccncc1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H18ClN5O/c1-12-11-23-7-5-16(12)19-6-8-24-21(27-19)25-13(2)17-10-14-9-15(22)3-4-18(14)26-20(17)28/h3-11,13H,1-2H3,(H,26,28)(H,24,25,27)	ZYFNXYYHWAJCDL-UHFFFAOYSA-N	383813	US10280150, Cmpd No I-96::US10550099, Compound I-96	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383813&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995787	404853100							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766637	COc1cnccc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C21H18ClN5O2/c1-12(16-10-13-9-14(22)3-4-17(13)26-20(16)28)25-21-24-8-6-18(27-21)15-5-7-23-11-19(15)29-2/h3-12H,1-2H3,(H,26,28)(H,24,25,27)	CHXKOUFZWGFLLU-UHFFFAOYSA-N	383814	US10280150, Cmpd No I-97::US10550099, Compound I-97	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383814&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995788	404853101							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766639	C[C@H](Nc1nccc(n1)-c1cccc2CCOc12)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C23H19ClN4O2/c1-13(18-12-15-11-16(24)5-6-19(15)27-22(18)29)26-23-25-9-7-20(28-23)17-4-2-3-14-8-10-30-21(14)17/h2-7,9,11-13H,8,10H2,1H3,(H,27,29)(H,25,26,28)	GHXJNHBCMPUUDN-UHFFFAOYSA-N	383815	US10280150, Cmpd No I-98::US10550099, Compound I-98	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383815	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383815&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995789	404853102							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766641	COc1ccncc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C21H18ClN5O2/c1-12(15-10-13-9-14(22)3-4-17(13)26-20(15)28)25-21-24-8-5-18(27-21)16-11-23-7-6-19(16)29-2/h3-12H,1-2H3,(H,26,28)(H,24,25,27)	GEQSTKKQQZWLIO-UHFFFAOYSA-N	383816	US10280150, Cmpd No I-99::US10550099, Compound I-99	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383816&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995790	404853103							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766643	COCc1ccccc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C23H21ClN4O2/c1-14(19-12-16-11-17(24)7-8-20(16)27-22(19)29)26-23-25-10-9-21(28-23)18-6-4-3-5-15(18)13-30-2/h3-12,14H,13H2,1-2H3,(H,27,29)(H,25,26,28)	TVYGOHOYOGUOMC-UHFFFAOYSA-N	383817	US10280150, Cmpd No I-100::US10550099, Compound I-100	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383817&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995791	404853104							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766645	C[C@H](Nc1nccc(n1)-c1ccccc1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H17ClN4O/c1-13(17-12-15-11-16(22)7-8-18(15)25-20(17)27)24-21-23-10-9-19(26-21)14-5-3-2-4-6-14/h2-13H,1H3,(H,25,27)(H,23,24,26)	NZOMXICZNNFASS-UHFFFAOYSA-N	383818	US10280150, Cmpd No I-101::US10550099, Compound I-101	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383818&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995792	404853105							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766647	COc1ccccc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C22H19ClN4O2/c1-13(17-12-14-11-15(23)7-8-18(14)26-21(17)28)25-22-24-10-9-19(27-22)16-5-3-4-6-20(16)29-2/h3-13H,1-2H3,(H,26,28)(H,24,25,27)	IQFCCNAYJBBZJK-UHFFFAOYSA-N	383819	US10280150, Cmpd No I-102::US10550099, Compound I-102	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383819&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995793	404853106							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766649	C[C@H](Nc1ncc(Br)c(C)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C16H14BrClN4O/c1-8(20-16-19-7-13(17)9(2)21-16)12-6-10-5-11(18)3-4-14(10)22-15(12)23/h3-8H,1-2H3,(H,22,23)(H,19,20,21)	LRXDGWLIIXZVIH-UHFFFAOYSA-N	383820	US10280150, Cmpd No I-103::US10550099, Compound I-103	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383820&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995794	404853107							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766650	CC(C)[C@H]1COCCN1c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C22H26ClN5O2/c1-13(2)19-12-30-9-8-28(19)20-6-7-24-22(27-20)25-14(3)17-11-15-10-16(23)4-5-18(15)26-21(17)29/h4-7,10-11,13-14,19H,8-9,12H2,1-3H3,(H,26,29)(H,24,25,27)	XWMSCEUHLMXSMF-UHFFFAOYSA-N	383821	US10280150, Cmpd No I-104::US10550099, Compound I-104	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383821&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995795	404853108							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766652	C[C@H](Nc1nccc(n1)S(C)(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C16H15ClN4O3S/c1-9(19-16-18-6-5-14(21-16)25(2,23)24)12-8-10-7-11(17)3-4-13(10)20-15(12)22/h3-9H,1-2H3,(H,20,22)(H,18,19,21)	JXXITMVRMCXOBH-UHFFFAOYSA-N	383822	US10280150, Cmpd No I-105::US10550099, Compound I-105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383822	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383822&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995796	404853109							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766653	CC(C)C[S@@](=O)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C19H21ClN4O2S/c1-11(2)10-27(26)17-6-7-21-19(24-17)22-12(3)15-9-13-8-14(20)4-5-16(13)23-18(15)25/h4-9,11-12H,10H2,1-3H3,(H,23,25)(H,21,22,24)	GHWNEVSMHYJYGX-UHFFFAOYSA-N	383823	US10280150, Cmpd No I-106::US10550099, Compound I-106	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383823	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383823&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995797	404853110							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766654	CC(C)CSc1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C19H21ClN4OS/c1-11(2)10-26-17-6-7-21-19(24-17)22-12(3)15-9-13-8-14(20)4-5-16(13)23-18(15)25/h4-9,11-12H,10H2,1-3H3,(H,23,25)(H,21,22,24)	PZVQTGDEAWLXEC-UHFFFAOYSA-N	383824	US10280150, Cmpd No I-107::US10550099, Compound I-107	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383824	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383824&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995798	404853111							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766655	CC(C)CS(=O)(=O)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C19H21ClN4O3S/c1-11(2)10-28(26,27)17-6-7-21-19(24-17)22-12(3)15-9-13-8-14(20)4-5-16(13)23-18(15)25/h4-9,11-12H,10H2,1-3H3,(H,23,25)(H,21,22,24)	JWODKUSMFJMMAF-UHFFFAOYSA-N	383825	US10280150, Cmpd No I-108::US10550099, Compound I-108	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383825	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383825&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995799	404853112							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766656	CC(C)C[S@](=O)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C19H21ClN4O2S/c1-11(2)10-27(26)17-6-7-21-19(24-17)22-12(3)15-9-13-8-14(20)4-5-16(13)23-18(15)25/h4-9,11-12H,10H2,1-3H3,(H,23,25)(H,21,22,24)	GHWNEVSMHYJYGX-UHFFFAOYSA-N	383826	US10280150, Cmpd No I-109::US10550099, Compound I-109	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383826&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995800	404853113							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766657	C[C@H](Nc1nccc(SCc2ccccc2)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C22H19ClN4OS/c1-14(18-12-16-11-17(23)7-8-19(16)26-21(18)28)25-22-24-10-9-20(27-22)29-13-15-5-3-2-4-6-15/h2-12,14H,13H2,1H3,(H,26,28)(H,24,25,27)	QXUPZFJZYSVEPB-UHFFFAOYSA-N	383827	US10280150, Cmpd No I-110::US10550099, Compound I-110	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383827	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383827&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995801	404853114							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766658	C[C@H](Nc1nccc(n1)S(C)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C16H15ClN4O2S/c1-9(19-16-18-6-5-14(21-16)24(2)23)12-8-10-7-11(17)3-4-13(10)20-15(12)22/h3-9H,1-2H3,(H,20,22)(H,18,19,21)	AXXSHNHVVCXWHF-UHFFFAOYSA-N	383828	US10280150, Cmpd No I-111::US10550099, Compound I-111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383828&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995802	404853115							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766660	C[C@H](Nc1nccc(n1)[S@@](C)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C16H15ClN4O2S/c1-9(19-16-18-6-5-14(21-16)24(2)23)12-8-10-7-11(17)3-4-13(10)20-15(12)22/h3-9H,1-2H3,(H,20,22)(H,18,19,21)	AXXSHNHVVCXWHF-UHFFFAOYSA-N	383829	US10280150, Cmpd No I-112::US10550099, Compound I-112	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383829&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995803	404853116							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766662	C[C@H](Nc1nccc(n1)[S@](C)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C16H15ClN4O2S/c1-9(19-16-18-6-5-14(21-16)24(2)23)12-8-10-7-11(17)3-4-13(10)20-15(12)22/h3-9H,1-2H3,(H,20,22)(H,18,19,21)	AXXSHNHVVCXWHF-UHFFFAOYSA-N	383830	US10280150, Cmpd No I-113::US10550099, Compound I-113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383830	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383830&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995804	404853117							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766664	C[C@H](Nc1nccc(n1)C(N)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C16H14ClN5O2/c1-8(20-16-19-5-4-13(22-16)14(18)23)11-7-9-6-10(17)2-3-12(9)21-15(11)24/h2-8H,1H3,(H2,18,23)(H,21,24)(H,19,20,22)	MWOAARCSKQYXGZ-UHFFFAOYSA-N	383831	US10280150, Cmpd No I-114::US10550099, Compound I-114	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383831	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383831&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995805	404853118							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766666	CNC(=O)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C17H16ClN5O2/c1-9(21-17-20-6-5-14(23-17)16(25)19-2)12-8-10-7-11(18)3-4-13(10)22-15(12)24/h3-9H,1-2H3,(H,19,25)(H,22,24)(H,20,21,23)	XROXWMTXPYXKKQ-UHFFFAOYSA-N	383832	US10280150, Cmpd No I-115::US10550099, Compound I-115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383832&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995806	404853119							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766668	CC(C)CNC(=O)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C20H22ClN5O2/c1-11(2)10-23-19(28)17-6-7-22-20(26-17)24-12(3)15-9-13-8-14(21)4-5-16(13)25-18(15)27/h4-9,11-12H,10H2,1-3H3,(H,23,28)(H,25,27)(H,22,24,26)	GQWWANCCZKWTPD-UHFFFAOYSA-N	383833	US10280150, Cmpd No I-116::US10550099, Compound I-116	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383833&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995807	404853120							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766670	CC(C)NC(=O)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C19H20ClN5O2/c1-10(2)22-18(27)16-6-7-21-19(25-16)23-11(3)14-9-12-8-13(20)4-5-15(12)24-17(14)26/h4-11H,1-3H3,(H,22,27)(H,24,26)(H,21,23,25)	LOPBJHFLEQDMOX-UHFFFAOYSA-N	383834	US10280150, Cmpd No I-117::US10550099, Compound I-117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383834&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995808	404853121							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766672	CC(C)CC(c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1)S(C)(=O)=O |r|	InChI=1S/C21H25ClN4O3S/c1-12(2)9-19(30(4,28)29)18-7-8-23-21(26-18)24-13(3)16-11-14-10-15(22)5-6-17(14)25-20(16)27/h5-8,10-13,19H,9H2,1-4H3,(H,25,27)(H,23,24,26)	XMTBCGCRXWOYSR-UHFFFAOYSA-N	383835	US10280150, Cmpd No I-118::US10550099, Compound I-118	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383835&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995809	404853122							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766673	C[C@H](Nc1nccc(CN2CCCS2(=O)=O)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H20ClN5O3S/c1-12(16-10-13-9-14(20)3-4-17(13)24-18(16)26)22-19-21-6-5-15(23-19)11-25-7-2-8-29(25,27)28/h3-6,9-10,12H,2,7-8,11H2,1H3,(H,24,26)(H,21,22,23)	UNPQITPTKPUWDP-UHFFFAOYSA-N	383836	US10280150, Cmpd No I-119::US10550099, Compound I-119	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383836	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383836&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995810	404853123							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766674	C[C@H](Nc1nccc(n1)C1CCCS1(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H19ClN4O3S/c1-11(14-10-12-9-13(20)4-5-15(12)23-18(14)25)22-19-21-7-6-16(24-19)17-3-2-8-28(17,26)27/h4-7,9-11,17H,2-3,8H2,1H3,(H,23,25)(H,21,22,24)	BUOAAKSJXUNMBB-UHFFFAOYSA-N	383837	US10280150, Cmpd No I-120::US10550099, Compound I-120	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383837&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995811	404853124							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766675	CC(C)CS(=O)(=O)Cc1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C20H23ClN4O3S/c1-12(2)10-29(27,28)11-16-6-7-22-20(24-16)23-13(3)17-9-14-8-15(21)4-5-18(14)25-19(17)26/h4-9,12-13H,10-11H2,1-3H3,(H,25,26)(H,22,23,24)	YLLMKQNZHYPHDJ-UHFFFAOYSA-N	383838	US10280150, Cmpd No I-121::US10550099, Compound I-121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383838&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995812	404853125							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766677	C[C@H](Nc1nccc(NC2CCOC2)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H20ClN5O2/c1-11(15-9-12-8-13(20)2-3-16(12)24-18(15)26)22-19-21-6-4-17(25-19)23-14-5-7-27-10-14/h2-4,6,8-9,11,14H,5,7,10H2,1H3,(H,24,26)(H2,21,22,23,25)	OSPDNQADXBUIGJ-UHFFFAOYSA-N	383839	US10280150, Cmpd No I-122::US10550099, Compound I-122	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383839&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995813	404853126							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766678	C[C@H](Nc1nccc(n1)N1CCNC1=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H17ClN6O2/c1-10(13-9-11-8-12(19)2-3-14(11)23-16(13)26)22-17-20-5-4-15(24-17)25-7-6-21-18(25)27/h2-5,8-10H,6-7H2,1H3,(H,21,27)(H,23,26)(H,20,22,24)	PXBXSCWOPPEUND-UHFFFAOYSA-N	383840	US10280150, Cmpd No I-123::US10550099, Compound I-123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383840&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995814	404853127							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766680	C[C@H](Nc1nccc(n1)N1CCN(C)C1=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H19ClN6O2/c1-11(14-10-12-9-13(20)3-4-15(12)23-17(14)27)22-18-21-6-5-16(24-18)26-8-7-25(2)19(26)28/h3-6,9-11H,7-8H2,1-2H3,(H,23,27)(H,21,22,24)	GOKHXSJLURRDIY-UHFFFAOYSA-N	383841	US10280150, Cmpd No I-124::US10550099, Compound I-124	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383841	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383841&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995815	404853128							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766681	C[C@H](Nc1nccc(n1)N(C)C(=O)N(C)C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H21ClN6O2/c1-11(14-10-12-9-13(20)5-6-15(12)23-17(14)27)22-18-21-8-7-16(24-18)26(4)19(28)25(2)3/h5-11H,1-4H3,(H,23,27)(H,21,22,24)	WEVDONCAHJLHFT-UHFFFAOYSA-N	383842	US10280150, Cmpd No I-125::US10550099, Compound I-125	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383842	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383842&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995816	404853129							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766682	C[C@H](Nc1nccc(NC(=O)N(C)C)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H19ClN6O2/c1-10(13-9-11-8-12(19)4-5-14(11)22-16(13)26)21-17-20-7-6-15(23-17)24-18(27)25(2)3/h4-10H,1-3H3,(H,22,26)(H2,20,21,23,24,27)	WFBNTCXRKLJIED-UHFFFAOYSA-N	383843	US10280150, Cmpd No I-126::US10550099, Compound I-126	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383843&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995817	404853130							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766683	C[C@H](Nc1nccc(Nc2ncco2)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H15ClN6O2/c1-10(13-9-11-8-12(19)2-3-14(11)23-16(13)26)22-17-20-5-4-15(24-17)25-18-21-6-7-27-18/h2-10H,1H3,(H,23,26)(H2,20,21,22,24,25)	CTFSEORGMLXMEA-UHFFFAOYSA-N	383844	US10280150, Cmpd No I-127::US10550099, Compound I-127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383844&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995818	404853131							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766684	CC(C)CN(c1ncco1)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C22H23ClN6O2/c1-13(2)12-29(22-25-8-9-31-22)19-6-7-24-21(28-19)26-14(3)17-11-15-10-16(23)4-5-18(15)27-20(17)30/h4-11,13-14H,12H2,1-3H3,(H,27,30)(H,24,26,28)	SEHCQIODWYVOMA-UHFFFAOYSA-N	383845	US10280150, Cmpd No I-128::US10550099, Compound I-128	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383845&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995819	404853132							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766685	COC(=O)c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C17H15ClN4O3/c1-9(20-17-19-6-5-14(22-17)16(24)25-2)12-8-10-7-11(18)3-4-13(10)21-15(12)23/h3-9H,1-2H3,(H,21,23)(H,19,20,22)	HWKOMDVYLWZOHF-UHFFFAOYSA-N	383846	US10280150, Cmpd No I-129::US10550099, Compound I-129	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383846&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995820	404853133							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766687	C[C@H](Nc1nccc(CC(N)=O)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C17H16ClN5O2/c1-9(21-17-20-5-4-12(22-17)8-15(19)24)13-7-10-6-11(18)2-3-14(10)23-16(13)25/h2-7,9H,8H2,1H3,(H2,19,24)(H,23,25)(H,20,21,22)	IJLHVVCDSDQAMB-UHFFFAOYSA-N	383847	US10280150, Cmpd No I-130::US10550099, Compound I-130	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383847&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995821	404853134							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766688	CNC(=O)Cc1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C18H18ClN5O2/c1-10(22-18-21-6-5-13(23-18)9-16(25)20-2)14-8-11-7-12(19)3-4-15(11)24-17(14)26/h3-8,10H,9H2,1-2H3,(H,20,25)(H,24,26)(H,21,22,23)	GONZWVQBAKEPNN-UHFFFAOYSA-N	383848	US10280150, Cmpd No I-131::US10550099, Compound I-131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383848	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383848&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995822	404853135							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766689	C[C@H](Nc1nccc(CNS(C)(=O)=O)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C17H18ClN5O3S/c1-10(14-8-11-7-12(18)3-4-15(11)23-16(14)24)21-17-19-6-5-13(22-17)9-20-27(2,25)26/h3-8,10,20H,9H2,1-2H3,(H,23,24)(H,19,21,22)	KJZGZRFCJIAGEE-UHFFFAOYSA-N	383849	US10280150, Cmpd No I-132::US10550099, Compound I-132	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383849&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995823	404853136							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766690	C[C@H](Nc1nccc(CS(C)(=O)=O)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C17H17ClN4O3S/c1-10(20-17-19-6-5-13(21-17)9-26(2,24)25)14-8-11-7-12(18)3-4-15(11)22-16(14)23/h3-8,10H,9H2,1-2H3,(H,22,23)(H,19,20,21)	IHNPKRIHCDREAU-UHFFFAOYSA-N	383850	US10280150, Cmpd No I-133::US10550099, Compound I-133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383850&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995824	404853137							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766692	COC(=O)C(c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1)S(C)(=O)=O |r|	InChI=1S/C19H19ClN4O5S/c1-10(13-9-11-8-12(20)4-5-14(11)23-17(13)25)22-19-21-7-6-15(24-19)16(18(26)29-2)30(3,27)28/h4-10,16H,1-3H3,(H,23,25)(H,21,22,24)	IPUFMQPBVAODSS-UHFFFAOYSA-N	383851	US10280150, Cmpd No I-134::US10550099, Compound I-134	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383851&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995825	404853138							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766694	C[C@H](Nc1nccc(n1)C(C)S(C)(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C18H19ClN4O3S/c1-10(14-9-12-8-13(19)4-5-16(12)22-17(14)24)21-18-20-7-6-15(23-18)11(2)27(3,25)26/h4-11H,1-3H3,(H,22,24)(H,20,21,23)	KXBLRXRFMXLHJH-UHFFFAOYSA-N	383852	US10280150, Cmpd No I-135::US10550099, Compound I-135	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383852&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995826	404853139							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766696	C[C@H](Nc1nccc(n1)C1(CC1)S(C)(=O)=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H19ClN4O3S/c1-11(14-10-12-9-13(20)3-4-15(12)23-17(14)25)22-18-21-8-5-16(24-18)19(6-7-19)28(2,26)27/h3-5,8-11H,6-7H2,1-2H3,(H,23,25)(H,21,22,24)	BFKQVSMYACUROC-UHFFFAOYSA-N	383853	US10280150, Cmpd No I-136::US10550099, Compound I-136	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383853&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995827	404853140							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766697	C[C@H](Nc1nccc(CN(C2CC2)C(C)=O)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C21H22ClN5O2/c1-12(18-10-14-9-15(22)3-6-19(14)26-20(18)29)24-21-23-8-7-16(25-21)11-27(13(2)28)17-4-5-17/h3,6-10,12,17H,4-5,11H2,1-2H3,(H,26,29)(H,23,24,25)	PYGGSCQLQQQAIE-UHFFFAOYSA-N	383854	US10280150, Cmpd No I-137::US10550099, Compound I-137	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383854&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995828	404853141							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766698	C[C@H](Nc1nccc(n1)N1CCCC1=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H18ClN5O2/c1-11(14-10-12-9-13(20)4-5-15(12)23-18(14)27)22-19-21-7-6-16(24-19)25-8-2-3-17(25)26/h4-7,9-11H,2-3,8H2,1H3,(H,23,27)(H,21,22,24)	CZWJVTIINQSCPD-UHFFFAOYSA-N	383855	US10280150, Cmpd No I-138::US10550099, Compound I-138	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383855&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995829	404853142							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766700	C[C@H](Nc1nccc(N)n1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C15H14ClN5O/c1-8(19-15-18-5-4-13(17)21-15)11-7-9-6-10(16)2-3-12(9)20-14(11)22/h2-8H,1H3,(H,20,22)(H3,17,18,19,21)	CNPIUCDVYIYDJF-UHFFFAOYSA-N	383856	US10280150, Cmpd No I-139::US10550099, Compound I-139	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383856&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995830	404853143							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766701	C[C@@H](Nc1nccc(n1)N1CCCOC1=O)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H18ClN5O3/c1-11(14-10-12-9-13(20)3-4-15(12)23-17(14)26)22-18-21-6-5-16(24-18)25-7-2-8-28-19(25)27/h3-6,9-11H,2,7-8H2,1H3,(H,23,26)(H,21,22,24)	UIZWIEDZQJZKCM-UHFFFAOYSA-N	383857	US10280150, Cmpd No I-140::US10550099, Compound I-140	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383857&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995831	404853144							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766702	COc1nc(N[C@H](C)c2cc3cc(Cl)c(F)cc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C17H13ClFN5O2/c1-8(22-17-21-7-10(6-20)16(24-17)26-2)11-3-9-4-12(18)13(19)5-14(9)23-15(11)25/h3-5,7-8H,1-2H3,(H,23,25)(H,21,22,24)	UCQMQHNCVXBAFQ-UHFFFAOYSA-N	383858	US10280150, Cmpd No I-141::US10550099, Compound I-141	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383858&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995832	404853145							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766704	COc1nc(NC(C)c2cc3cc(Cl)c(F)cc3[nH]c2=O)ncc1C#N	InChI=1S/C17H13ClFN5O2/c1-8(22-17-21-7-10(6-20)16(24-17)26-2)11-3-9-4-12(18)13(19)5-14(9)23-15(11)25/h3-5,7-8H,1-2H3,(H,23,25)(H,21,22,24)	UCQMQHNCVXBAFQ-UHFFFAOYSA-N	383859	US10280150, Cmpd No I-142::US10550099, Compound I-142	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383859&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995833	404853146							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766706	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1ncc(C#N)c(OC)n1 |r|	InChI=1S/C18H16ClN5O3/c1-9(22-18-21-8-11(7-20)17(24-18)27-3)12-4-10-5-13(19)15(26-2)6-14(10)23-16(12)25/h4-6,8-9H,1-3H3,(H,23,25)(H,21,22,24)	DIDCUOGCZYTDKE-UHFFFAOYSA-N	383860	US10280150, Cmpd No I-143::US10550099, Compound I-143	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383860&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995834	404853147							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766708	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@@H](C)Nc1ncc(C#N)c(OC)n1 |r|	InChI=1S/C18H16ClN5O3/c1-9(22-18-21-8-11(7-20)17(24-18)27-3)12-4-10-5-13(19)15(26-2)6-14(10)23-16(12)25/h4-6,8-9H,1-3H3,(H,23,25)(H,21,22,24)	DIDCUOGCZYTDKE-UHFFFAOYSA-N	383861	US10280150, Cmpd No I-144::US10550099, Compound I-144	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383861&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995835	404853148							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766710	COc1cc2[nH]c(=O)c(cc2cc1Cl)C(C)Nc1ncc(C#N)c(OC)n1	InChI=1S/C18H16ClN5O3/c1-9(22-18-21-8-11(7-20)17(24-18)27-3)12-4-10-5-13(19)15(26-2)6-14(10)23-16(12)25/h4-6,8-9H,1-3H3,(H,23,25)(H,21,22,24)	DIDCUOGCZYTDKE-UHFFFAOYSA-N	383862	US10280150, Cmpd No I-145::US10550099, Compound I-145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383862&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995836	404853149							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766712	COc1cc2[nH]c(=O)c(cc2cc1Cl)C(C)Nc1nccc(n1)N1CCOC1=O	InChI=1S/C19H18ClN5O4/c1-10(22-18-21-4-3-16(24-18)25-5-6-29-19(25)27)12-7-11-8-13(20)15(28-2)9-14(11)23-17(12)26/h3-4,7-10H,5-6H2,1-2H3,(H,23,26)(H,21,22,24)	CWHCWFAEESICOW-UHFFFAOYSA-N	383863	US10280150, Cmpd No I-146::US10550099, Compound I-146	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383863&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995837	404853150							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766714	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1nccc(n1)N1CCOC1=O |r|	InChI=1S/C19H18ClN5O4/c1-10(22-18-21-4-3-16(24-18)25-5-6-29-19(25)27)12-7-11-8-13(20)15(28-2)9-14(11)23-17(12)26/h3-4,7-10H,5-6H2,1-2H3,(H,23,26)(H,21,22,24)	CWHCWFAEESICOW-UHFFFAOYSA-N	383864	US10280150, Cmpd No I-147::US10550099, Compound I-147	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383864&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995838	404853151							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766715	COc1cc2[nH]c(=O)c(cc2cc1Cl)[C@@H](C)Nc1nccc(n1)N1CCOC1=O |r|	InChI=1S/C19H18ClN5O4/c1-10(22-18-21-4-3-16(24-18)25-5-6-29-19(25)27)12-7-11-8-13(20)15(28-2)9-14(11)23-17(12)26/h3-4,7-10H,5-6H2,1-2H3,(H,23,26)(H,21,22,24)	CWHCWFAEESICOW-UHFFFAOYSA-N	383865	US10280150, Cmpd No I-148::US10550099, Compound I-148	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383865&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995839	404853152							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766716	CC(Nc1nccc(NC(C)=O)n1)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O	InChI=1S/C23H21ClN6O3/c1-13(27-23-26-8-6-21(30-23)28-14(2)31)17-9-15-10-18(24)20(11-19(15)29-22(17)32)33-12-16-5-3-4-7-25-16/h3-11,13H,12H2,1-2H3,(H,29,32)(H2,26,27,28,30,31)	ZLSBJNJDAPTCAQ-UHFFFAOYSA-N	383866	US10280150, Cmpd No I-149::US10550099, Compound I-149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383866&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995840	404853153							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766718	COc1nc(NC(C)c2cc3cc(Cl)c(OCc4ccccn4)cc3[nH]c2=O)ncc1C#N	InChI=1S/C23H19ClN6O3/c1-13(28-23-27-11-15(10-25)22(30-23)32-2)17-7-14-8-18(24)20(9-19(14)29-21(17)31)33-12-16-5-3-4-6-26-16/h3-9,11,13H,12H2,1-2H3,(H,29,31)(H,27,28,30)	FDOFXICXZHTQAU-UHFFFAOYSA-N	383867	US10280150, Cmpd No I-150::US10550099, Compound I-150	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383867&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995841	404853154							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766720	COc1nc(N[C@@H](C)c2cc3cc(Cl)c(OCc4ccccn4)cc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C23H19ClN6O3/c1-13(28-23-27-11-15(10-25)22(30-23)32-2)17-7-14-8-18(24)20(9-19(14)29-21(17)31)33-12-16-5-3-4-6-26-16/h3-9,11,13H,12H2,1-2H3,(H,29,31)(H,27,28,30)	FDOFXICXZHTQAU-UHFFFAOYSA-N	383868	US10280150, Cmpd No I-151::US10550099, Compound I-151	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383868&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995842	404853155							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766722	C[C@H](Nc1ncc(C#N)c(O)n1)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O |r|	InChI=1S/C22H17ClN6O3/c1-12(27-22-26-10-14(9-24)20(30)29-22)16-6-13-7-17(23)19(8-18(13)28-21(16)31)32-11-15-4-2-3-5-25-15/h2-8,10,12H,11H2,1H3,(H,28,31)(H2,26,27,29,30)	PTFHNRSWZULIAX-UHFFFAOYSA-N	383869	US10280150, Cmpd No I-152::US10550099, Compound I-152	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383869&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995843	404853156							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766724	C[C@H](Nc1ncc(C#N)c(C)n1)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O |r|	InChI=1S/C23H19ClN6O2/c1-13-16(10-25)11-27-23(28-13)29-14(2)18-7-15-8-19(24)21(9-20(15)30-22(18)31)32-12-17-5-3-4-6-26-17/h3-9,11,14H,12H2,1-2H3,(H,30,31)(H,27,28,29)	ZZHWAZPQCJQQTG-UHFFFAOYSA-N	383870	US10280150, Cmpd No I-153::US10550099, Compound I-153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383870&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995844	404853157							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766726	COC(=O)Nc1ccnc(N[C@@H](C)c2cc3cc(Cl)c(OCc4ccccn4)cc3[nH]c2=O)n1 |r|	InChI=1S/C23H21ClN6O4/c1-13(27-22-26-8-6-20(29-22)30-23(32)33-2)16-9-14-10-17(24)19(11-18(14)28-21(16)31)34-12-15-5-3-4-7-25-15/h3-11,13H,12H2,1-2H3,(H,28,31)(H2,26,27,29,30,32)	LUSHQOUYLVLMAK-UHFFFAOYSA-N	383871	US10280150, Cmpd No I-154::US10550099, Compound I-154	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383871&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995845	404853158							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766728	COc1nc(N[C@@H](C)c2cc3cc(Cl)cnc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C16H13ClN6O2/c1-8(21-16-20-6-10(5-18)15(23-16)25-2)12-4-9-3-11(17)7-19-13(9)22-14(12)24/h3-4,6-8H,1-2H3,(H,19,22,24)(H,20,21,23)	NIJGOGFMWXNCAT-UHFFFAOYSA-N	383872	US10280150, Cmpd No I-155::US10550099, Compound I-155	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383872&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995846	404853159							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766730	COc1nc(N[C@@H](C)c2nc3cc(Cl)ccc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C16H13ClN6O2/c1-8(20-16-19-7-9(6-18)15(23-16)25-2)13-14(24)22-11-4-3-10(17)5-12(11)21-13/h3-5,7-8H,1-2H3,(H,22,24)(H,19,20,23)	ITXHROZCEFEDIA-UHFFFAOYSA-N	383873	US10280150, Cmpd No I-156	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383873&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995847	404853160							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766732	COc1nc(N[C@H](C)c2nc3cc(Cl)ccc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C16H13ClN6O2/c1-8(20-16-19-7-9(6-18)15(23-16)25-2)13-14(24)22-11-4-3-10(17)5-12(11)21-13/h3-5,7-8H,1-2H3,(H,22,24)(H,19,20,23)	ITXHROZCEFEDIA-UHFFFAOYSA-N	383874	US10280150, Cmpd No I-157	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383874&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995848	404853161							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766734	COc1nc(N[C@@H](C)c2cc3cc(Cl)c(O[C@H](C)c4ccccn4)cc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C24H21ClN6O3/c1-13(29-24-28-12-16(11-26)23(31-24)33-3)17-8-15-9-18(25)21(10-20(15)30-22(17)32)34-14(2)19-6-4-5-7-27-19/h4-10,12-14H,1-3H3,(H,30,32)(H,28,29,31)	IHHNLVLFXFFARZ-UHFFFAOYSA-N	383875	US10280150, Cmpd No I-158::US10550099, Compound I-158	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383875&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995849	404853162							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766736	COc1nc(N[C@@H](C)c2cc3cc(Cl)c(OCC4CC4)cc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C21H20ClN5O3/c1-11(25-21-24-9-14(8-23)20(27-21)29-2)15-5-13-6-16(22)18(30-10-12-3-4-12)7-17(13)26-19(15)28/h5-7,9,11-12H,3-4,10H2,1-2H3,(H,26,28)(H,24,25,27)	IIDYGTPVIWYOGU-UHFFFAOYSA-N	383876	US10280150, Cmpd No I-159::US10550099, Compound I-159	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383876&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995850	404853163							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766738	C[C@H](Nc1nccc(NC(C)=O)n1)c1cc2cc(Cl)cc(F)c2[nH]c1=O |r|	InChI=1S/C17H15ClFN5O2/c1-8(21-17-20-4-3-14(23-17)22-9(2)25)12-6-10-5-11(18)7-13(19)15(10)24-16(12)26/h3-8H,1-2H3,(H,24,26)(H2,20,21,22,23,25)	ZFWGVHGZYGSYEF-UHFFFAOYSA-N	383877	US10280150, Cmpd No I-160::US10550099, Compound I-160	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383877&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995851	404853164							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766740	COc1nc(N[C@@H](C)c2cc3cc(Cl)cc(F)c3[nH]c2=O)ncc1C#N |r|	InChI=1S/C17H13ClFN5O2/c1-8(22-17-21-7-10(6-20)16(24-17)26-2)12-4-9-3-11(18)5-13(19)14(9)23-15(12)25/h3-5,7-8H,1-2H3,(H,23,25)(H,21,22,24)	SNCJSEKZDINTPO-UHFFFAOYSA-N	383878	US10280150, Cmpd No I-161::US10550099, Compound I-161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383878&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995852	404853165							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766742	COc1nc(N[C@@H](C)c2cc3cc(Cl)c(Br)cc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C17H13BrClN5O2/c1-8(22-17-21-7-10(6-20)16(24-17)26-2)11-3-9-4-13(19)12(18)5-14(9)23-15(11)25/h3-5,7-8H,1-2H3,(H,23,25)(H,21,22,24)	WVWHWIPYHVESPA-UHFFFAOYSA-N	383879	US10280150, Cmpd No I-162::US10550099, Compound I-162	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383879&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995853	404853166							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766744	COc1cc(OC)nc(NCc2cc3cc(Cl)ccc3[nH]c2=O)n1	InChI=1S/C16H15ClN4O3/c1-23-13-7-14(24-2)21-16(20-13)18-8-10-5-9-6-11(17)3-4-12(9)19-15(10)22/h3-7H,8H2,1-2H3,(H,19,22)(H,18,20,21)	FIKWNJUKJGGVDM-UHFFFAOYSA-N	383880	US10280150, Cmpd No I-163::US10550099, Compound I-163	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383880&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995854	404853167							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766745	CC(C)N(c1ccnc(NCc2cc3ccccc3[nH]c2=O)n1)S(C)(=O)=O	InChI=1S/C18H21N5O3S/c1-12(2)23(27(3,25)26)16-8-9-19-18(22-16)20-11-14-10-13-6-4-5-7-15(13)21-17(14)24/h4-10,12H,11H2,1-3H3,(H,21,24)(H,19,20,22)	UAZPTBWPCLMLSX-UHFFFAOYSA-N	383881	US10280150, Cmpd No I-164::US10550099, Compound I-164	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383881&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995855	404853168							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766746	CC(C)N(c1ccnc(NCc2cc3ccc(F)cc3[nH]c2=O)n1)S(C)(=O)=O	InChI=1S/C18H20FN5O3S/c1-11(2)24(28(3,26)27)16-6-7-20-18(23-16)21-10-13-8-12-4-5-14(19)9-15(12)22-17(13)25/h4-9,11H,10H2,1-3H3,(H,22,25)(H,20,21,23)	OCVAJLOLPVDELR-UHFFFAOYSA-N	383882	US10280150, Cmpd No I-165::US10550099, Compound I-165	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383882&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995856	404853169							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766747	CC(C)N(c1ccnc(NCc2cc3cc(C)ccc3[nH]c2=O)n1)S(C)(=O)=O	InChI=1S/C19H23N5O3S/c1-12(2)24(28(4,26)27)17-7-8-20-19(23-17)21-11-15-10-14-9-13(3)5-6-16(14)22-18(15)25/h5-10,12H,11H2,1-4H3,(H,22,25)(H,20,21,23)	BVFAUKJBUPJQFI-UHFFFAOYSA-N	383883	US10280150, Cmpd No I-166::US10550099, Compound I-166	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383883&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995857	404853170							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766748	CC(C)N(c1ccnc(NCc2cc3cc(ccc3[nH]c2=O)C(C)C)n1)S(C)(=O)=O	InChI=1S/C21H27N5O3S/c1-13(2)15-6-7-18-16(10-15)11-17(20(27)24-18)12-23-21-22-9-8-19(25-21)26(14(3)4)30(5,28)29/h6-11,13-14H,12H2,1-5H3,(H,24,27)(H,22,23,25)	IMLQQCVWAXGMBT-UHFFFAOYSA-N	383884	US10280150, Cmpd No I-167::US10550099, Compound I-167	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383884&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995858	404853171							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766749	Clc1ccc2[nH]c(=O)c(cc2c1)C1(CC1)Nc1nccc(n1)N1CCOC1=O	InChI=1S/C19H16ClN5O3/c20-12-1-2-14-11(9-12)10-13(16(26)22-14)19(4-5-19)24-17-21-6-3-15(23-17)25-7-8-28-18(25)27/h1-3,6,9-10H,4-5,7-8H2,(H,22,26)(H,21,23,24)	DHOJVHPWGDRGJX-UHFFFAOYSA-N	383885	US10280150, Cmpd No I-168::US10550099, Compound I-168	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383885&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995859	404853172							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766751	COc1nc(NC2(CC2)c2cc3cc(Cl)ccc3[nH]c2=O)ncc1C#N	InChI=1S/C18H14ClN5O2/c1-26-16-11(8-20)9-21-17(23-16)24-18(4-5-18)13-7-10-6-12(19)2-3-14(10)22-15(13)25/h2-3,6-7,9H,4-5H2,1H3,(H,22,25)(H,21,23,24)	SQKZXBLFCIZHCQ-UHFFFAOYSA-N	383886	US10280150, Cmpd No I-169::US10550099, Compound I-169	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383886&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995860	404853173							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766753	CC(C)(Nc1nccc(n1)N1CCOC1=O)c1cc2cc(Cl)ccc2[nH]c1=O	InChI=1S/C19H18ClN5O3/c1-19(2,13-10-11-9-12(20)3-4-14(11)22-16(13)26)24-17-21-6-5-15(23-17)25-7-8-28-18(25)27/h3-6,9-10H,7-8H2,1-2H3,(H,22,26)(H,21,23,24)	WQWAONHVORDCDB-UHFFFAOYSA-N	383887	US10280150, Cmpd No I-170::US10550099, Compound I-170	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383887	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383887&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995861	404853174							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766754	FCC(Nc1nccc(n1)N1CCOC1=O)c1cc2cc(Cl)ccc2[nH]c1=O	InChI=1S/C18H15ClFN5O3/c19-11-1-2-13-10(7-11)8-12(16(26)22-13)14(9-20)23-17-21-4-3-15(24-17)25-5-6-28-18(25)27/h1-4,7-8,14H,5-6,9H2,(H,22,26)(H,21,23,24)	INIGEQKXLNHIEQ-UHFFFAOYSA-N	383888	US10280150, Cmpd No I-171::US10550099, Compound I-171	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383888&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995862	404853175							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766755	COc1nc(NC(C)c2cc3cc(Cl)c(OCC4CC(F)(F)C4)cc3[nH]c2=O)ncc1C#N	InChI=1S/C22H20ClF2N5O3/c1-11(28-21-27-9-14(8-26)20(30-21)32-2)15-3-13-4-16(23)18(5-17(13)29-19(15)31)33-10-12-6-22(24,25)7-12/h3-5,9,11-12H,6-7,10H2,1-2H3,(H,29,31)(H,27,28,30)	IUPXBQBQSGKYHG-UHFFFAOYSA-N	383889	US10280150, Cmpd No I-172::US10550099, Compound I-172	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383889&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995863	404853176							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766757	CC(C)n1cncc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3n(C)c2=O)n1 |r|	InChI=1S/C22H23ClN6O/c1-13(2)29-12-24-11-20(29)18-7-8-25-22(27-18)26-14(3)17-10-15-9-16(23)5-6-19(15)28(4)21(17)30/h5-14H,1-4H3,(H,25,26,27)	GFUUTRABMIWYGA-UHFFFAOYSA-N	383890	US10280150, Cmpd No I-173::US10550099, Compound I-173	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383890&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118953995	404853177							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766759	COc1nc(N[C@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C17H14ClN5O2/c1-9(21-17-20-8-11(7-19)16(23-17)25-2)13-6-10-5-12(18)3-4-14(10)22-15(13)24/h3-6,8-9H,1-2H3,(H,22,24)(H,20,21,23)	QAFWVLDKBWIXLX-UHFFFAOYSA-N	383891	US10280150, Cmpd No I-174::US10550099, Compound I-174	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383891&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995864	404853178							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766761	COc1nc(N[C@@H](C)c2cc3cc(Cl)c(OC(C)C)cc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C20H20ClN5O3/c1-10(2)29-17-7-16-12(6-15(17)21)5-14(18(27)25-16)11(3)24-20-23-9-13(8-22)19(26-20)28-4/h5-7,9-11H,1-4H3,(H,25,27)(H,23,24,26)	PVBTVTWQUGLJJL-UHFFFAOYSA-N	383892	US10280150, Cmpd No I-175::US10550099, Compound I-175	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383892&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995865	404853179							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766763	COc1nc(N[C@@H](C)c2cc3cc(Cl)c(cc3[nH]c2=O)C2CC2)ncc1C#N |r|	InChI=1S/C20H18ClN5O2/c1-10(24-20-23-9-13(8-22)19(26-20)28-2)14-5-12-6-16(21)15(11-3-4-11)7-17(12)25-18(14)27/h5-7,9-11H,3-4H2,1-2H3,(H,25,27)(H,23,24,26)	IQGRWPVZOSEPGO-UHFFFAOYSA-N	383893	US10280150, Cmpd No I-176::US10550099, Compound I-176	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383893&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995866	404853180							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766765	COc1nc(N[C@@H](C)c2cc3ncccc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C16H14N6O2/c1-9(20-16-19-8-10(7-17)15(22-16)24-2)11-6-13-12(21-14(11)23)4-3-5-18-13/h3-6,8-9H,1-2H3,(H,21,23)(H,19,20,22)	SRXVJORPRMEGHD-UHFFFAOYSA-N	383894	US10280150, Cmpd No I-177::US10550099, Compound I-177	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5500							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383894&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995867	404853181							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766767	C[C@H](Nc1ncc(C#N)c(=O)[nH]1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C16H12ClN5O2/c1-8(20-16-19-7-10(6-18)14(23)22-16)12-5-9-4-11(17)2-3-13(9)21-15(12)24/h2-5,7-8H,1H3,(H,21,24)(H2,19,20,22,23)	HGDXPXJSJCBWKT-UHFFFAOYSA-N	383895	US10280150, Cmpd No I-178::US10550099, Compound I-178	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383895&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995868	404853182							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766769	C[C@H](Nc1nccc(NC(C)=O)n1)c1cc2cc(Cl)c(F)cc2[nH]c1=O |r|	InChI=1S/C17H15ClFN5O2/c1-8(21-17-20-4-3-15(24-17)22-9(2)25)11-5-10-6-12(18)13(19)7-14(10)23-16(11)26/h3-8H,1-2H3,(H,23,26)(H2,20,21,22,24,25)	HEULCGXPIFZLCP-UHFFFAOYSA-N	383896	US10280150, Cmpd No I-179::US10550099, Compound I-179	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383896&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995869	404853183							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766771	C[C@H](Nc1nccc(NC(=O)C2CC2)n1)c1cc2cc(Cl)c(F)cc2[nH]c1=O |r|	InChI=1S/C19H17ClFN5O2/c1-9(12-6-11-7-13(20)14(21)8-15(11)24-18(12)28)23-19-22-5-4-16(26-19)25-17(27)10-2-3-10/h4-10H,2-3H2,1H3,(H,24,28)(H2,22,23,25,26,27)	PFVGLDJJFIUPMI-UHFFFAOYSA-N	383897	US10280150, Cmpd No I-180::US10550099, Compound I-180	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383897&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995870	404853184							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766773	COc1nc(N[C@@H](C)c2cc3cc(Cl)c(F)cc3[nH]c2=O)ncc1C#N |r|	InChI=1S/C17H13ClFN5O2/c1-8(22-17-21-7-10(6-20)16(24-17)26-2)11-3-9-4-12(18)13(19)5-14(9)23-15(11)25/h3-5,7-8H,1-2H3,(H,23,25)(H,21,22,24)	UCQMQHNCVXBAFQ-UHFFFAOYSA-N	383898	US10280150, Cmpd No I-181::US10550099, Compound I-181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383898&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995871	404853185							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766775	C[C@H](Nc1nccc(NC(C)=O)n1)c1cc2cc(Cl)cnc2[nH]c1=O |r|	InChI=1S/C16H15ClN6O2/c1-8(20-16-18-4-3-13(22-16)21-9(2)24)12-6-10-5-11(17)7-19-14(10)23-15(12)25/h3-8H,1-2H3,(H,19,23,25)(H2,18,20,21,22,24)	PWDCFGXTJJQFIN-UHFFFAOYSA-N	383899	US10280150, Cmpd No I-182::US10550099, Compound I-182	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383899&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995872	404853186							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766777	C[C@H](Nc1nccc(n1)-n1nnnc1C1CC1)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H17ClN8O/c1-10(14-9-12-8-13(20)4-5-15(12)23-18(14)29)22-19-21-7-6-16(24-19)28-17(11-2-3-11)25-26-27-28/h4-11H,2-3H2,1H3,(H,23,29)(H,21,22,24)	VAVXHHABBZSMPQ-UHFFFAOYSA-N	383900	US10280150, Cmpd No I-183::US10550099, Compound I-183	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383900&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995873	404853187							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
766779	C[C@H](Nc1nccc(n1)-n1nnnc1C1CC1)c1cc2cc(Cl)cnc2[nH]c1=O |r|	InChI=1S/C18H16ClN9O/c1-9(13-7-11-6-12(19)8-21-15(11)24-17(13)29)22-18-20-5-4-14(23-18)28-16(10-2-3-10)25-26-27-28/h4-10H,2-3H2,1H3,(H,20,22,23)(H,21,24,29)	TVYSRTVGQLLENL-UHFFFAOYSA-N	383901	US10280150, Cmpd No I-184::US10550099, Compound I-184	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2QR50FF		aid1798568	US10280150	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	5/7/2019	2/21/2020	Forma Tm2	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383901	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383901&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			145995874	404853188							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777807	CCc1ccc(Nc2nc3ccccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)c(CC)c1 |r|	InChI=1S/C26H35N3/c1-6-19-12-13-22(20(7-2)15-19)27-25-28-23-10-8-9-11-24(23)29(25)21-14-18(3)16-26(4,5)17-21/h8-13,15,18,21H,6-7,14,16-17H2,1-5H3,(H,27,28)	GWTYXYCTKWSTBA-UHFFFAOYSA-N	389133	US9951027, 2-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 90.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389133	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389133&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310475	404957765							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777808	CCc1ccc(Nc2nc3ccccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)c(CC)c1	InChI=1S/C26H35N3/c1-6-19-12-13-22(20(7-2)15-19)27-25-28-23-10-8-9-11-24(23)29(25)21-14-18(3)16-26(4,5)17-21/h8-13,15,18,21H,6-7,14,16-17H2,1-5H3,(H,27,28)	GWTYXYCTKWSTBA-UHFFFAOYSA-N	389165	US9951027, 2-1-2::US9951027, 2-1-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 730							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389165	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389165&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310472	404957797							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777809	CCc1ccc(Nc2nc3ccccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)c(CC)c1	InChI=1S/C26H35N3/c1-6-19-12-13-22(20(7-2)15-19)27-25-28-23-10-8-9-11-24(23)29(25)21-14-18(3)16-26(4,5)17-21/h8-13,15,18,21H,6-7,14,16-17H2,1-5H3,(H,27,28)	GWTYXYCTKWSTBA-UHFFFAOYSA-N	389165	US9951027, 2-1-2::US9951027, 2-1-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389165	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389165&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310472	404957797							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777810	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(Oc3ccccc3)cc2)nc2ccccc12 |r|	InChI=1S/C28H31N3O/c1-20-17-22(19-28(2,3)18-20)31-26-12-8-7-11-25(26)30-27(31)29-21-13-15-24(16-14-21)32-23-9-5-4-6-10-23/h4-16,20,22H,17-19H2,1-3H3,(H,29,30)	MKAUFXIJEXOEQQ-UHFFFAOYSA-N	389167	US9951027, 2-2::(+-) N-(4-phenoxyphenyl)-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-2-amine	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 770							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389167	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389167&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318408	404957798							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777811	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C#N)nc2ccccc12 |r|	InChI=1S/C23H26N4/c1-16-12-19(14-23(2,3)13-16)27-21-7-5-4-6-20(21)26-22(27)25-18-10-8-17(15-24)9-11-18/h4-11,16,19H,12-14H2,1-3H3,(H,25,26)	HYPQAWLIIXIIKL-UHFFFAOYSA-N	389168	US9951027, 2-3::(+-) ({1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-2-yl}amino)benzonitrile	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1900							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389168	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389168&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318339	404957799							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777812	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)S(N)(=O)=O	InChI=1S/C24H29F3N4O3S/c1-22(2)12-16(13-23(3,4)14-22)31-20-10-9-18(35(28,32)33)11-19(20)30-21(31)29-15-5-7-17(8-6-15)34-24(25,26)27/h5-11,16H,12-14H2,1-4H3,(H,29,30)(H2,28,32,33)	XTOXMNUFDLGHHV-UHFFFAOYSA-N	389169	US9951027, 2-4::1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazole-5-sulfonamide	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 50.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389169	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389169&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318349	404957800							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777813	COC(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2cc1OC	InChI=1S/C27H32F3N3O4/c1-25(2)13-17(14-26(3,4)15-25)33-21-12-22(35-5)19(23(34)36-6)11-20(21)32-24(33)31-16-7-9-18(10-8-16)37-27(28,29)30/h7-12,17H,13-15H2,1-6H3,(H,31,32)	YBGOKVRNFNNQKH-UHFFFAOYSA-N	389170	US9951027, 2-5::methyl 6-methoxy-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)-phenyl]amino}-1H-benzimidazole-5-carboxylate	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389170	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389170&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311011	404957801							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777814	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)S(C)(=O)=O	InChI=1S/C25H30F3N3O3S/c1-23(2)13-17(14-24(3,4)15-23)31-21-11-10-19(35(5,32)33)12-20(21)30-22(31)29-16-6-8-18(9-7-16)34-25(26,27)28/h6-12,17H,13-15H2,1-5H3,(H,29,30)	ZNMKNJBAYXGQMT-UHFFFAOYSA-N	389171	US9951027, 2-6::5-(methylsulfonyl)-1-(3,3,5,5-tetramethylcyclohexyl)-N-[4-(trifluoromethoxy)-phenyl]-1H-benzimidazol-2-amine	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 140							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389171	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389171&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318532	404957802							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777815	COc1cc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C(O)=O	InChI=1S/C26H30F3N3O4/c1-24(2)12-16(13-25(3,4)14-24)32-20-11-21(35-5)18(22(33)34)10-19(20)31-23(32)30-15-6-8-17(9-7-15)36-26(27,28)29/h6-11,16H,12-14H2,1-5H3,(H,30,31)(H,33,34)	GFGUAHJSTJHQPU-UHFFFAOYSA-N	389172	US9951027, 2-7::6-methoxy-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]-amino}-1H-benzimidazole-5-carboxylicacid	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 6.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389172	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389172&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			91844689	404957803							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777816	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)S(O)(=O)=O |r|	InChI=1S/C23H26F3N3O4S/c1-14-10-16(13-22(2,3)12-14)29-20-9-8-18(34(30,31)32)11-19(20)28-21(29)27-15-4-6-17(7-5-15)33-23(24,25)26/h4-9,11,14,16H,10,12-13H2,1-3H3,(H,27,28)(H,30,31,32)	QEJXMIBWDIDRLK-UHFFFAOYSA-N	389173	US9951027, 2-10::(+-) 2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-sulfonic acid	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 150							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389173	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389173&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318534	404957804							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777817	COC(=O)c1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C28H37N3O2/c1-18(2)19-8-11-21(12-9-19)29-26-30-23-14-20(25(32)33-7)10-13-24(23)31(26)22-15-27(3,4)17-28(5,6)16-22/h8-14,18,22H,15-17H2,1-7H3,(H,29,30)	VHIBKBGNVOQYNJ-UHFFFAOYSA-N	389174	US9951027, 2-11::methyl 2-{[4-(propan-2-yl)phenyl]amino}-1-(3,3,5,5-tetramethylcyclohexyl)-1H-benzimidazole-5-carboxylate	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 90.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389174	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389174&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311012	404957805							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777818	CC(C)c1ccc(Nc2nc3cc(ccc3n2C2CC(C)(C)CC(C)(C)C2)C(O)=O)cc1	InChI=1S/C27H35N3O2/c1-17(2)18-7-10-20(11-8-18)28-25-29-22-13-19(24(31)32)9-12-23(22)30(25)21-14-26(3,4)16-27(5,6)15-21/h7-13,17,21H,14-16H2,1-6H3,(H,28,29)(H,31,32)	CCULMJBCBXKSHY-UHFFFAOYSA-N	389175	US9951027, 2-12::2-{[4-(propan-2-yl)phenyl]amino}-1-(3,3,5,5-tetramethylcyclohexyl)-1H-benzimidazole-5-carboxylic acid	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 50.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389175	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389175&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311078	404957806							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777819	CC(C)(C)OC(=O)Nc1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C29H37F3N4O3/c1-26(2,3)39-25(37)34-19-10-13-23-22(14-19)35-24(33-18-8-11-21(12-9-18)38-29(30,31)32)36(23)20-15-27(4,5)17-28(6,7)16-20/h8-14,20H,15-17H2,1-7H3,(H,33,35)(H,34,37)	KMVAADJBIRCWTJ-UHFFFAOYSA-N	389176	US9951027, 2-13::tert-butyl [1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]-amino}-1H-benzimidazol-5-yl]carbamate	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2700							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389176	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389176&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318374	404957807							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777820	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(NC(=O)OC(C)(C)C)ccc12 |r|	InChI=1S/C28H35F3N4O3/c1-17-13-20(16-27(5,6)15-17)35-23-12-9-19(33-25(36)38-26(2,3)4)14-22(23)34-24(35)32-18-7-10-21(11-8-18)37-28(29,30)31/h7-12,14,17,20H,13,15-16H2,1-6H3,(H,32,34)(H,33,36)	DFJLLVVPSXCNLD-UHFFFAOYSA-N	389177	US9951027, 2-14::(+-) tert-butyl (2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)carbamate	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389177	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389177&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318342	404957808							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777821	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(NC(=O)OC(C)(C)C)ccc12	InChI=1S/C28H35F3N4O3/c1-17-13-20(16-27(5,6)15-17)35-23-12-9-19(33-25(36)38-26(2,3)4)14-22(23)34-24(35)32-18-7-10-21(11-8-18)37-28(29,30)31/h7-12,14,17,20H,13,15-16H2,1-6H3,(H,32,34)(H,33,36)	DFJLLVVPSXCNLD-UHFFFAOYSA-N	389178	US9951027, 2-14-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389178	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389178&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318342	404957809							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777822	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)F)cc2)nc2cc(NC(=O)OC(C)(C)C)ccc12	InChI=1S/C28H36F2N4O3/c1-17-13-20(16-28(5,6)15-17)34-23-12-9-19(32-26(35)37-27(2,3)4)14-22(23)33-25(34)31-18-7-10-21(11-8-18)36-24(29)30/h7-12,14,17,20,24H,13,15-16H2,1-6H3,(H,31,33)(H,32,35)	HXWZXNZDLOGSFP-UHFFFAOYSA-N	389179	US9951027, 2-14-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2800							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389179	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389179&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011513	404957810							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777823	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(N)ccc12	InChI=1S/C24H29F3N4O/c1-22(2)12-17(13-23(3,4)14-22)31-20-10-5-15(28)11-19(20)30-21(31)29-16-6-8-18(9-7-16)32-24(25,26)27/h5-11,17H,12-14,28H2,1-4H3,(H,29,30)	YVQKGBUHWJXBGR-UHFFFAOYSA-N	389180	US9951027, 2-15::1-(3,3,5,5-tetramethylcyclohexyl)-N2-[4-(trifluoromethoxy)phenyl]-1H-benzimidazole-2,5-diamine, salt with hydrochloric acid	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389180	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389180&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311048	404957811							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777824	CC(=O)Nc1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C26H31F3N4O2/c1-16(34)30-18-8-11-22-21(12-18)32-23(31-17-6-9-20(10-7-17)35-26(27,28)29)33(22)19-13-24(2,3)15-25(4,5)14-19/h6-12,19H,13-15H2,1-5H3,(H,30,34)(H,31,32)	STPWMRSVEWXRAI-UHFFFAOYSA-N	389181	US9951027, 2-16::N-[1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazol-5-yl]acetamide	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1100							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389181	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389181&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318535	404957812							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777825	CCCC(=O)Nc1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C28H35F3N4O2/c1-6-7-24(36)32-19-10-13-23-22(14-19)34-25(33-18-8-11-21(12-9-18)37-28(29,30)31)35(23)20-15-26(2,3)17-27(4,5)16-20/h8-14,20H,6-7,15-17H2,1-5H3,(H,32,36)(H,33,34)	LJOHCTGNEKIVHC-UHFFFAOYSA-N	389182	US9951027, 2-17	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1300							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389182	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389182&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011514	404957813							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777826	COC(=O)Nc1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C26H31F3N4O3/c1-24(2)13-18(14-25(3,4)15-24)33-21-11-8-17(31-23(34)35-5)12-20(21)32-22(33)30-16-6-9-19(10-7-16)36-26(27,28)29/h6-12,18H,13-15H2,1-5H3,(H,30,32)(H,31,34)	MYDPBHLQMIBLMQ-UHFFFAOYSA-N	389183	US9951027, 2-18	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389183	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389183&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318377	404957814							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777827	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(NC(=O)Nc3ccccc3)ccc12	InChI=1S/C31H34F3N5O2/c1-29(2)17-23(18-30(3,4)19-29)39-26-15-12-22(37-28(40)36-20-8-6-5-7-9-20)16-25(26)38-27(39)35-21-10-13-24(14-11-21)41-31(32,33)34/h5-16,23H,17-19H2,1-4H3,(H,35,38)(H2,36,37,40)	CNUSBFSPPJXVEA-UHFFFAOYSA-N	389184	US9951027, 2-19	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389184	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389184&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318536	404957815							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777828	CNC(=O)Nc1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C26H32F3N5O2/c1-24(2)13-18(14-25(3,4)15-24)34-21-11-8-17(32-23(35)30-5)12-20(21)33-22(34)31-16-6-9-19(10-7-16)36-26(27,28)29/h6-12,18H,13-15H2,1-5H3,(H,31,33)(H2,30,32,35)	WUNLAAHGTVPYFR-UHFFFAOYSA-N	389185	US9951027, 2-20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389185	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389185&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011515	404957816							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777829	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(NS(C)(=O)=O)ccc12	InChI=1S/C25H31F3N4O3S/c1-23(2)13-18(14-24(3,4)15-23)32-21-11-8-17(31-36(5,33)34)12-20(21)30-22(32)29-16-6-9-19(10-7-16)35-25(26,27)28/h6-12,18,31H,13-15H2,1-5H3,(H,29,30)	YCIJBIMNYVCWIH-UHFFFAOYSA-N	389186	US9951027, 2-23::N-[1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazol-5-yl]methanesulfonamide::US9951027, 2-21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 360							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389186	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389186&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318184	404957817							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777830	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(NS(=O)(=O)C3CC3)ccc12	InChI=1S/C27H33F3N4O3S/c1-25(2)14-19(15-26(3,4)16-25)34-23-12-7-18(33-38(35,36)21-10-11-21)13-22(23)32-24(34)31-17-5-8-20(9-6-17)37-27(28,29)30/h5-9,12-13,19,21,33H,10-11,14-16H2,1-4H3,(H,31,32)	CSPSICBBJQBXNJ-UHFFFAOYSA-N	389187	US9951027, 2-22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 900							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389187	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389187&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318415	404957818							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777831	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(NS(C)(=O)=O)ccc12	InChI=1S/C25H31F3N4O3S/c1-23(2)13-18(14-24(3,4)15-23)32-21-11-8-17(31-36(5,33)34)12-20(21)30-22(32)29-16-6-9-19(10-7-16)35-25(26,27)28/h6-12,18,31H,13-15H2,1-5H3,(H,29,30)	YCIJBIMNYVCWIH-UHFFFAOYSA-N	389186	US9951027, 2-23::N-[1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazol-5-yl]methanesulfonamide::US9951027, 2-21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1500							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389186	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389186&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318184	404957817							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777832	COC(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)F)cc3)nc2c1 |r|	InChI=1S/C25H29F2N3O3/c1-15-11-18(14-25(2,3)13-15)30-21-10-5-16(22(31)32-4)12-20(21)29-24(30)28-17-6-8-19(9-7-17)33-23(26)27/h5-10,12,15,18,23H,11,13-14H2,1-4H3,(H,28,29)	RQGHSWSXRSSPPL-UHFFFAOYSA-N	389189	US9951027, 2-24::(+-) methyl 2-{[4-(difluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylate	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 3100							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389189	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389189&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310662	404957819							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777833	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)F)cc3)nc2c1	InChI=1S/C25H29F2N3O3/c1-15-11-18(14-25(2,3)13-15)30-21-10-5-16(22(31)32-4)12-20(21)29-24(30)28-17-6-8-19(9-7-17)33-23(26)27/h5-10,12,15,18,23H,11,13-14H2,1-4H3,(H,28,29)	RQGHSWSXRSSPPL-UHFFFAOYSA-N	389190	US9951027, 2-24-2::US9951027, 2-24-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 8000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389190	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389190&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310307	404957820							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777834	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)F)cc3)nc2c1	InChI=1S/C25H29F2N3O3/c1-15-11-18(14-25(2,3)13-15)30-21-10-5-16(22(31)32-4)12-20(21)29-24(30)28-17-6-8-19(9-7-17)33-23(26)27/h5-10,12,15,18,23H,11,13-14H2,1-4H3,(H,28,29)	RQGHSWSXRSSPPL-UHFFFAOYSA-N	389190	US9951027, 2-24-2::US9951027, 2-24-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 3000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389190	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389190&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310307	404957820							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777835	COC(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)S(C)(=O)=O)nc2c1	InChI=1S/C25H31N3O4S/c1-16-12-19(15-25(2,3)14-16)28-22-11-6-17(23(29)32-4)13-21(22)27-24(28)26-18-7-9-20(10-8-18)33(5,30)31/h6-11,13,16,19H,12,14-15H2,1-5H3,(H,26,27)	GDHLDKNOTPKXLP-UHFFFAOYSA-N	389192	US9951027, 2-25-2::US9951027, 2-25	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389192	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389192&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318421	404957821							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777836	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)S(C)(=O)=O)nc2c1	InChI=1S/C25H31N3O4S/c1-16-12-19(15-25(2,3)14-16)28-22-11-6-17(23(29)32-4)13-21(22)27-24(28)26-18-7-9-20(10-8-18)33(5,30)31/h6-11,13,16,19H,12,14-15H2,1-5H3,(H,26,27)	GDHLDKNOTPKXLP-UHFFFAOYSA-N	389193	US9951027, 2-25-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389193	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389193&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318422	404957822							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777837	COC(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)S(C)(=O)=O)nc2c1	InChI=1S/C25H31N3O4S/c1-16-12-19(15-25(2,3)14-16)28-22-11-6-17(23(29)32-4)13-21(22)27-24(28)26-18-7-9-20(10-8-18)33(5,30)31/h6-11,13,16,19H,12,14-15H2,1-5H3,(H,26,27)	GDHLDKNOTPKXLP-UHFFFAOYSA-N	389192	US9951027, 2-25-2::US9951027, 2-25	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389192	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389192&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318421	404957821							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777838	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)F)cc2)nc2cc(ccc12)C(O)=O |r|	InChI=1S/C24H27F2N3O3/c1-14-10-17(13-24(2,3)12-14)29-20-9-4-15(21(30)31)11-19(20)28-23(29)27-16-5-7-18(8-6-16)32-22(25)26/h4-9,11,14,17,22H,10,12-13H2,1-3H3,(H,27,28)(H,30,31)	IYOHUGNSEBHVSY-UHFFFAOYSA-N	389195	US9951027, 2-26-2::(+-) 2-{[4-(difluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylic acid::US9951027, 2-26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 290							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389195	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389195&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310464	404957823							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777839	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)F)cc2)nc2cc(ccc12)C(O)=O |r|	InChI=1S/C24H27F2N3O3/c1-14-10-17(13-24(2,3)12-14)29-20-9-4-15(21(30)31)11-19(20)28-23(29)27-16-5-7-18(8-6-16)32-22(25)26/h4-9,11,14,17,22H,10,12-13H2,1-3H3,(H,27,28)(H,30,31)	IYOHUGNSEBHVSY-UHFFFAOYSA-N	389196	US9951027, 2-26-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 450							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389196	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389196&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310466	404957824							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777840	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)F)cc2)nc2cc(ccc12)C(O)=O |r|	InChI=1S/C24H27F2N3O3/c1-14-10-17(13-24(2,3)12-14)29-20-9-4-15(21(30)31)11-19(20)28-23(29)27-16-5-7-18(8-6-16)32-22(25)26/h4-9,11,14,17,22H,10,12-13H2,1-3H3,(H,27,28)(H,30,31)	IYOHUGNSEBHVSY-UHFFFAOYSA-N	389195	US9951027, 2-26-2::(+-) 2-{[4-(difluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylic acid::US9951027, 2-26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 120							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389195	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389195&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310464	404957823							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777841	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)S(C)(=O)=O)nc2cc(ccc12)C(O)=O |r|	InChI=1S/C24H29N3O4S/c1-15-11-18(14-24(2,3)13-15)27-21-10-5-16(22(28)29)12-20(21)26-23(27)25-17-6-8-19(9-7-17)32(4,30)31/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,25,26)(H,28,29)	JUIHDONOSWCBIL-UHFFFAOYSA-N	389198	US9951027, 2-27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389198	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389198&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318541	404957825							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777842	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(cc2)S(C)(=O)=O)nc2cc(ccc12)C(O)=O	InChI=1S/C24H29N3O4S/c1-15-11-18(14-24(2,3)13-15)27-21-10-5-16(22(28)29)12-20(21)26-23(27)25-17-6-8-19(9-7-17)32(4,30)31/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,25,26)(H,28,29)	JUIHDONOSWCBIL-UHFFFAOYSA-N	389199	US9951027, 2-27-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389199	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389199&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124013458	404957826							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777843	CC1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)S(C)(=O)=O)nc2cc(ccc12)C(O)=O |r|	InChI=1S/C24H29N3O4S/c1-15-11-18(14-24(2,3)13-15)27-21-10-5-16(22(28)29)12-20(21)26-23(27)25-17-6-8-19(9-7-17)32(4,30)31/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,25,26)(H,28,29)	JUIHDONOSWCBIL-UHFFFAOYSA-N	389200	US9951027, 2-27-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 3300							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389200	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389200&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011516	404957827							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777844	COC(=O)c1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1C	InChI=1S/C27H32F3N3O3/c1-16-20(23(34)35-6)11-12-21-22(16)32-24(31-17-7-9-19(10-8-17)36-27(28,29)30)33(21)18-13-25(2,3)15-26(4,5)14-18/h7-12,18H,13-15H2,1-6H3,(H,31,32)	SRXNHWDQILPATO-UHFFFAOYSA-N	389201	US9951027, 2-28::methyl 4-methyl-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)-phenyl]amino}-1H-benzimidazole-5-carboxylate	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 110							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389201	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389201&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310979	404957828							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777845	Cc1c(ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc12)C(O)=O	InChI=1S/C26H30F3N3O3/c1-15-19(22(33)34)10-11-20-21(15)31-23(30-16-6-8-18(9-7-16)35-26(27,28)29)32(20)17-12-24(2,3)14-25(4,5)13-17/h6-11,17H,12-14H2,1-5H3,(H,30,31)(H,33,34)	QTOUNMFUBPKLDQ-UHFFFAOYSA-N	389202	US9951027, 2-29::4-methyl-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazole-5-carboxylic acid	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 90.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389202	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389202&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310973	404957829							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777846	Cc1c(ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc12)C(N)=O	InChI=1S/C26H31F3N4O2/c1-15-19(22(30)34)10-11-20-21(15)32-23(31-16-6-8-18(9-7-16)35-26(27,28)29)33(20)17-12-24(2,3)14-25(4,5)13-17/h6-11,17H,12-14H2,1-5H3,(H2,30,34)(H,31,32)	CMSKPVGGCSQLOD-UHFFFAOYSA-N	389203	US9951027, 2-30::4-methyl-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazole-5-carboxamide	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389203	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389203&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318538	404957830							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777847	COC(=O)c1ccc2n([C@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1C |r|	InChI=1S/C26H30F3N3O3/c1-15-12-18(14-25(3,4)13-15)32-21-11-10-20(23(33)34-5)16(2)22(21)31-24(32)30-17-6-8-19(9-7-17)35-26(27,28)29/h6-11,15,18H,12-14H2,1-5H3,(H,30,31)	AAJGWYAOOGDVKW-UHFFFAOYSA-N	389204	US9951027, 2-31::(+-) methyl 4-methyl-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(trans)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylate	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2700							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389204	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389204&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311003	404957831							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777848	C[C@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2c(C)c(ccc12)C(O)=O |r|	InChI=1S/C25H28F3N3O3/c1-14-11-17(13-24(3,4)12-14)31-20-10-9-19(22(32)33)15(2)21(20)30-23(31)29-16-5-7-18(8-6-16)34-25(26,27)28/h5-10,14,17H,11-13H2,1-4H3,(H,29,30)(H,32,33)	UZOSCNKBPBEHBO-UHFFFAOYSA-N	389205	US9951027, 2-32::(+-) 4-methyl-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(trans)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylic acid	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389205	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389205&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311022	404957832							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777849	C[C@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2c(C)c(ccc12)C(N)=O |r|	InChI=1S/C25H29F3N4O2/c1-14-11-17(13-24(3,4)12-14)32-20-10-9-19(22(29)33)15(2)21(20)31-23(32)30-16-5-7-18(8-6-16)34-25(26,27)28/h5-10,14,17H,11-13H2,1-4H3,(H2,29,33)(H,30,31)	QHXOZQZVZZTWTJ-UHFFFAOYSA-N	389206	US9951027, 2-33::(+-) 4-methyl-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(trans)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxamide	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389206	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389206&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311044	404957833							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777850	COC(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2cc1C	InChI=1S/C27H32F3N3O3/c1-16-11-22-21(12-20(16)23(34)35-6)32-24(31-17-7-9-19(10-8-17)36-27(28,29)30)33(22)18-13-25(2,3)15-26(4,5)14-18/h7-12,18H,13-15H2,1-6H3,(H,31,32)	ITXWGFXDWRKSKS-UHFFFAOYSA-N	389207	US9951027, 2-34::methyl 6-methyl-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]-amino}-1H-benzimidazole-5-carboxylate	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389207	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389207&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311020	404957834							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777851	Cc1cc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C(O)=O	InChI=1S/C26H30F3N3O3/c1-15-10-21-20(11-19(15)22(33)34)31-23(30-16-6-8-18(9-7-16)35-26(27,28)29)32(21)17-12-24(2,3)14-25(4,5)13-17/h6-11,17H,12-14H2,1-5H3,(H,30,31)(H,33,34)	MZRKRNSYBRBYMC-UHFFFAOYSA-N	389208	US9951027, 2-35::6-methyl-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazole-5-carboxylic acid	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 7.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389208	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389208&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310971	404957835							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777852	Cc1cc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C(N)=O	InChI=1S/C26H31F3N4O2/c1-15-10-21-20(11-19(15)22(30)34)32-23(31-16-6-8-18(9-7-16)35-26(27,28)29)33(21)17-12-24(2,3)14-25(4,5)13-17/h6-11,17H,12-14H2,1-5H3,(H2,30,34)(H,31,32)	GPSZCQBKBVNOLC-UHFFFAOYSA-N	389209	US9951027, 2-36::6-methyl-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazole-5-carboxamide	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389209	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389209&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318343	404957836							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777853	COC(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@H](C)CC(C)(C)C3)c2cc1C |r|	InChI=1S/C26H30F3N3O3/c1-15-10-18(14-25(3,4)13-15)32-22-11-16(2)20(23(33)34-5)12-21(22)31-24(32)30-17-6-8-19(9-7-17)35-26(27,28)29/h6-9,11-12,15,18H,10,13-14H2,1-5H3,(H,30,31)	PMNJTYOUPJCQOI-UHFFFAOYSA-N	389210	US9951027, 2-37::(+-) methyl 6-methyl-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(trans)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylate	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 580							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389210	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389210&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310972	404957837							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777854	C[C@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(O)=O)c(C)cc12 |r|	InChI=1S/C25H28F3N3O3/c1-14-9-17(13-24(3,4)12-14)31-21-10-15(2)19(22(32)33)11-20(21)30-23(31)29-16-5-7-18(8-6-16)34-25(26,27)28/h5-8,10-11,14,17H,9,12-13H2,1-4H3,(H,29,30)(H,32,33)	BWEHGQFGUCYWMB-UHFFFAOYSA-N	389211	US9951027, 2-38::(+-) 6-methyl-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(trans)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylic acid	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389211	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389211&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311080	404957838							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777855	COC(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1C |r|	InChI=1S/C26H30F3N3O3/c1-15-10-18(14-25(3,4)13-15)32-22-11-16(2)20(23(33)34-5)12-21(22)31-24(32)30-17-6-8-19(9-7-17)35-26(27,28)29/h6-9,11-12,15,18H,10,13-14H2,1-5H3,(H,30,31)	PMNJTYOUPJCQOI-UHFFFAOYSA-N	389212	US9951027, 2-39::(+-) methyl 6-methyl-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylate	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 400							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389212	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389212&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310978	404957839							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777856	COC(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1C	InChI=1S/C26H30F3N3O3/c1-15-10-18(14-25(3,4)13-15)32-22-11-16(2)20(23(33)34-5)12-21(22)31-24(32)30-17-6-8-19(9-7-17)35-26(27,28)29/h6-9,11-12,15,18H,10,13-14H2,1-5H3,(H,30,31)	PMNJTYOUPJCQOI-UHFFFAOYSA-N	389213	US9951027, 2-39-2::US9951027, 2-39-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 950							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389213	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389213&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310978	404957840							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777857	COC(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1C	InChI=1S/C26H30F3N3O3/c1-15-10-18(14-25(3,4)13-15)32-22-11-16(2)20(23(33)34-5)12-21(22)31-24(32)30-17-6-8-19(9-7-17)35-26(27,28)29/h6-9,11-12,15,18H,10,13-14H2,1-5H3,(H,30,31)	PMNJTYOUPJCQOI-UHFFFAOYSA-N	389213	US9951027, 2-39-2::US9951027, 2-39-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389213	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389213&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310978	404957840							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777858	COC(=O)c1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1C	InChI=1S/C28H37N3O3/c1-17(2)34-22-10-8-20(9-11-22)29-27-30-24-14-23(26(32)33-7)19(4)13-25(24)31(27)21-12-18(3)15-28(5,6)16-21/h8-11,13-14,17-18,21H,12,15-16H2,1-7H3,(H,29,30)	AMVNPFVZOMKHPF-UHFFFAOYSA-N	389215	US9951027, 2-40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 380							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389215	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389215&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318425	404957841							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777859	COC(=O)c1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1C	InChI=1S/C28H37N3O3/c1-17(2)34-22-10-8-20(9-11-22)29-27-30-24-14-23(26(32)33-7)19(4)13-25(24)31(27)21-12-18(3)15-28(5,6)16-21/h8-11,13-14,17-18,21H,12,15-16H2,1-7H3,(H,29,30)	AMVNPFVZOMKHPF-UHFFFAOYSA-N	389216	US9951027, 2-40-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 900							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389216	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389216&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318424	404957842							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777860	CC(C)Oc1ccc(Nc2nc3cc(C(O)=O)c(C)cc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C27H35N3O3/c1-16(2)33-21-9-7-19(8-10-21)28-26-29-23-13-22(25(31)32)18(4)12-24(23)30(26)20-11-17(3)14-27(5,6)15-20/h7-10,12-13,16-17,20H,11,14-15H2,1-6H3,(H,28,29)(H,31,32)	KSWHCUXDWSAARY-UHFFFAOYSA-N	389217	US9951027, 2-40-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 190							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389217	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389217&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318427	404957843							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777861	CC(C)c1ccc(Nc2nc3cc(C(O)=O)c(C)cc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C27H35N3O2/c1-16(2)19-7-9-20(10-8-19)28-26-29-23-13-22(25(31)32)18(4)12-24(23)30(26)21-11-17(3)14-27(5,6)15-21/h7-10,12-13,16-17,21H,11,14-15H2,1-6H3,(H,28,29)(H,31,32)	IATHDAJCYPMUDV-UHFFFAOYSA-N	389218	US9951027, 2-41-2::US9951027, 2-41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389218	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389218&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130201955	404957844							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777862	CC(C)c1ccc(Nc2nc3cc(C(O)=O)c(C)cc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1	InChI=1S/C27H35N3O2/c1-16(2)19-7-9-20(10-8-19)28-26-29-23-13-22(25(31)32)18(4)12-24(23)30(26)21-11-17(3)14-27(5,6)15-21/h7-10,12-13,16-17,21H,11,14-15H2,1-6H3,(H,28,29)(H,31,32)	IATHDAJCYPMUDV-UHFFFAOYSA-N	389219	US9951027, 2-41-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 190							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389219	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389219&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318507	404957845							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777863	CC(C)c1ccc(Nc2nc3cc(C(O)=O)c(C)cc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C27H35N3O2/c1-16(2)19-7-9-20(10-8-19)28-26-29-23-13-22(25(31)32)18(4)12-24(23)30(26)21-11-17(3)14-27(5,6)15-21/h7-10,12-13,16-17,21H,11,14-15H2,1-6H3,(H,28,29)(H,31,32)	IATHDAJCYPMUDV-UHFFFAOYSA-N	389218	US9951027, 2-41-2::US9951027, 2-41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389218	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389218&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130201955	404957844							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777864	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(O)=O)c(C)cc12 |r|	InChI=1S/C25H28F3N3O3/c1-14-9-17(13-24(3,4)12-14)31-21-10-15(2)19(22(32)33)11-20(21)30-23(31)29-16-5-7-18(8-6-16)34-25(26,27)28/h5-8,10-11,14,17H,9,12-13H2,1-4H3,(H,29,30)(H,32,33)	BWEHGQFGUCYWMB-UHFFFAOYSA-N	389221	US9951027, 2-42::(+-) 6-methyl-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylic acid	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389221	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389221&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310974	404957846							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777865	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(O)=O)c(C)cc12 |r|	InChI=1S/C25H28F3N3O3/c1-14-9-17(13-24(3,4)12-14)31-21-10-15(2)19(22(32)33)11-20(21)30-23(31)29-16-5-7-18(8-6-16)34-25(26,27)28/h5-8,10-11,14,17H,9,12-13H2,1-4H3,(H,29,30)(H,32,33)	BWEHGQFGUCYWMB-UHFFFAOYSA-N	389222	US9951027, 2-42-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389222	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389222&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318506	404957847							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777866	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(O)=O	InChI=1S/C24H26F3N3O3/c1-14-10-17(13-23(2,3)12-14)30-20-9-4-15(21(31)32)11-19(20)29-22(30)28-16-5-7-18(8-6-16)33-24(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,28,29)(H,31,32)	CNNGWPABWSPMPW-UHFFFAOYSA-N	389223	US9951027, 2-75-1::US9951027, 2-75-2::US9951027, 2-81-1::US9951027, 2-42-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 6.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389223	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389223&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318454	404957848							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777867	COC(=O)c1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1F	InChI=1S/C26H29F4N3O3/c1-24(2)12-16(13-25(3,4)14-24)33-19-11-10-18(22(34)35-5)20(27)21(19)32-23(33)31-15-6-8-17(9-7-15)36-26(28,29)30/h6-11,16H,12-14H2,1-5H3,(H,31,32)	BXQKQKKGWPPHFF-UHFFFAOYSA-N	389224	US9951027, 2-43::methyl 4-fluoro-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]-amino}-1H-benzimidazole-5-carboxylate	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389224	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389224&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310994	404957849							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777868	COC(=O)c1cc(F)c2n(C3CC(C)CC(C)(C)C3)c(Nc3ccc(OC(C)C)cc3)nc2c1	InChI=1S/C27H34FN3O3/c1-16(2)34-21-9-7-19(8-10-21)29-26-30-23-13-18(25(32)33-6)12-22(28)24(23)31(26)20-11-17(3)14-27(4,5)15-20/h7-10,12-13,16-17,20H,11,14-15H2,1-6H3,(H,29,30)	HIXYYMDJGYTXGL-UHFFFAOYSA-N	389225	US9951027, 2-44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 580							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389225	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389225&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011517	404957850							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777869	COC(=O)c1cc(F)c2n(C3CC(C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C27H34FN3O2/c1-16(2)18-7-9-20(10-8-18)29-26-30-23-13-19(25(32)33-6)12-22(28)24(23)31(26)21-11-17(3)14-27(4,5)15-21/h7-10,12-13,16-17,21H,11,14-15H2,1-6H3,(H,29,30)	ICXGONWHSMYION-UHFFFAOYSA-N	389226	US9951027, 2-45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 500							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389226	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389226&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011518	404957851							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777870	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2c(F)c(ccc12)C(O)=O	InChI=1S/C25H27F4N3O3/c1-23(2)11-15(12-24(3,4)13-23)32-18-10-9-17(21(33)34)19(26)20(18)31-22(32)30-14-5-7-16(8-6-14)35-25(27,28)29/h5-10,15H,11-13H2,1-4H3,(H,30,31)(H,33,34)	GZRLSRGVDKGJCQ-UHFFFAOYSA-N	389227	US9951027, 2-46::4-fluoro-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazole-5-carboxylic acid	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389227	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389227&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318344	404957852							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777871	CC(C)Oc1ccc(Nc2nc3c(F)c(ccc3n2C2CC(C)(C)CC(C)(C)C2)C(O)=O)cc1	InChI=1S/C27H34FN3O3/c1-16(2)34-19-9-7-17(8-10-19)29-25-30-23-21(12-11-20(22(23)28)24(32)33)31(25)18-13-26(3,4)15-27(5,6)14-18/h7-12,16,18H,13-15H2,1-6H3,(H,29,30)(H,32,33)	IMHQRWCRNDGNTR-UHFFFAOYSA-N	389228	US9951027, 2-47	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389228	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389228&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318345	404957853							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777872	CC(C)c1ccc(Nc2nc3c(F)c(ccc3n2C2CC(C)(C)CC(C)(C)C2)C(O)=O)cc1	InChI=1S/C27H34FN3O2/c1-16(2)17-7-9-18(10-8-17)29-25-30-23-21(12-11-20(22(23)28)24(32)33)31(25)19-13-26(3,4)15-27(5,6)14-19/h7-12,16,19H,13-15H2,1-6H3,(H,29,30)(H,32,33)	PRJRMOOAEVMWHK-UHFFFAOYSA-N	389229	US9951027, 2-48	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 9.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389229	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389229&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318346	404957854							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777873	COC(=O)c1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1OC	InChI=1S/C27H32F3N3O4/c1-25(2)13-17(14-26(3,4)15-25)33-20-12-11-19(23(34)36-6)22(35-5)21(20)32-24(33)31-16-7-9-18(10-8-16)37-27(28,29)30/h7-12,17H,13-15H2,1-6H3,(H,31,32)	SGHAEXUIWXIWPJ-UHFFFAOYSA-N	389230	US9951027, 2-49::methyl 4-methoxy-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazole-5-carboxylate	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 800							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389230	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389230&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311000	404957855							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777874	COc1c(ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc12)C(O)=O	InChI=1S/C26H30F3N3O4/c1-24(2)12-16(13-25(3,4)14-24)32-19-11-10-18(22(33)34)21(35-5)20(19)31-23(32)30-15-6-8-17(9-7-15)36-26(27,28)29/h6-11,16H,12-14H2,1-5H3,(H,30,31)(H,33,34)	DREDXTPVGSVDHB-UHFFFAOYSA-N	389231	US9951027, 2-50::4-methoxy-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazole-5-carboxylic acid	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 100.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389231	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389231&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311121	404957856							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777875	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccccc12 |r|	InChI=1S/C23H26F3N3O/c1-15-12-17(14-22(2,3)13-15)29-20-7-5-4-6-19(20)28-21(29)27-16-8-10-18(11-9-16)30-23(24,25)26/h4-11,15,17H,12-14H2,1-3H3,(H,27,28)	RJZJWNYCLYAWCD-UHFFFAOYSA-N	389232	(+-) N-[4-(trifluoromethoxy)phenyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-2-amine::US9951027, 2-52::US9951027, 2-51	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389232	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389232&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310390	404957857							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777876	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccccc12	InChI=1S/C23H26F3N3O/c1-15-12-17(14-22(2,3)13-15)29-20-7-5-4-6-19(20)28-21(29)27-16-8-10-18(11-9-16)30-23(24,25)26/h4-11,15,17H,12-14H2,1-3H3,(H,27,28)	RJZJWNYCLYAWCD-UHFFFAOYSA-N	389233	US9951027, 2-52-2::US9951027, 2-51-2::US9951027, 2-51-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 330							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389233	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389233&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310377	404957858							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777877	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccccc12	InChI=1S/C23H26F3N3O/c1-15-12-17(14-22(2,3)13-15)29-20-7-5-4-6-19(20)28-21(29)27-16-8-10-18(11-9-16)30-23(24,25)26/h4-11,15,17H,12-14H2,1-3H3,(H,27,28)	RJZJWNYCLYAWCD-UHFFFAOYSA-N	389233	US9951027, 2-52-2::US9951027, 2-51-2::US9951027, 2-51-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389233	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389233&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310377	404957858							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777878	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccccc12 |r|	InChI=1S/C23H26F3N3O/c1-15-12-17(14-22(2,3)13-15)29-20-7-5-4-6-19(20)28-21(29)27-16-8-10-18(11-9-16)30-23(24,25)26/h4-11,15,17H,12-14H2,1-3H3,(H,27,28)	RJZJWNYCLYAWCD-UHFFFAOYSA-N	389232	(+-) N-[4-(trifluoromethoxy)phenyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-2-amine::US9951027, 2-52::US9951027, 2-51	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 390							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389232	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389232&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310390	404957857							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777879	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccccc12	InChI=1S/C23H26F3N3O/c1-15-12-17(14-22(2,3)13-15)29-20-7-5-4-6-19(20)28-21(29)27-16-8-10-18(11-9-16)30-23(24,25)26/h4-11,15,17H,12-14H2,1-3H3,(H,27,28)	RJZJWNYCLYAWCD-UHFFFAOYSA-N	389236	US9951027, 2-52-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 790							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389236	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389236&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310390	404957859							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777880	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccccc12	InChI=1S/C23H26F3N3O/c1-15-12-17(14-22(2,3)13-15)29-20-7-5-4-6-19(20)28-21(29)27-16-8-10-18(11-9-16)30-23(24,25)26/h4-11,15,17H,12-14H2,1-3H3,(H,27,28)	RJZJWNYCLYAWCD-UHFFFAOYSA-N	389233	US9951027, 2-52-2::US9951027, 2-51-2::US9951027, 2-51-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 180							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389233	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389233&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310377	404957858							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777881	CCOc1ccc(Nc2nc3ccccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C24H31N3O/c1-5-28-20-12-10-18(11-13-20)25-23-26-21-8-6-7-9-22(21)27(23)19-14-17(2)15-24(3,4)16-19/h6-13,17,19H,5,14-16H2,1-4H3,(H,25,26)	IQAROIYDXTUAPB-UHFFFAOYSA-N	389238	US9951027, 2-53::(+-) N-(4-ethoxyphenyl)-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-2-amine	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 240							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389238	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389238&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311062	404957860							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777882	CCOc1ccc(Nc2nc3ccccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C24H31N3O/c1-5-28-20-12-10-18(11-13-20)25-23-26-21-8-6-7-9-22(21)27(23)19-14-17(2)15-24(3,4)16-19/h6-13,17,19H,5,14-16H2,1-4H3,(H,25,26)	IQAROIYDXTUAPB-UHFFFAOYSA-N	389239	US9951027, 2-53-2::US9951027, 2-53-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 280							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389239	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389239&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311259	404957861							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777883	CCOc1ccc(Nc2nc3ccccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C24H31N3O/c1-5-28-20-12-10-18(11-13-20)25-23-26-21-8-6-7-9-22(21)27(23)19-14-17(2)15-24(3,4)16-19/h6-13,17,19H,5,14-16H2,1-4H3,(H,25,26)	IQAROIYDXTUAPB-UHFFFAOYSA-N	389239	US9951027, 2-53-2::US9951027, 2-53-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 160							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389239	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389239&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311259	404957861							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777884	CCc1ccc(Nc2nc3c(F)cccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)c(CC)c1 |r|	InChI=1S/C26H34FN3/c1-6-18-11-12-22(19(7-2)14-18)28-25-29-24-21(27)9-8-10-23(24)30(25)20-13-17(3)15-26(4,5)16-20/h8-12,14,17,20H,6-7,13,15-16H2,1-5H3,(H,28,29)	OKCOYVAZMNDUCV-UHFFFAOYSA-N	389241	US9951027, 2-54::(+-) N-(2,4-diethylphenyl)-4-fluoro-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-2-amine	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 90.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389241	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389241&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311087	404957862							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777885	CCc1ccc(Nc2nc3c(F)cccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)c(CC)c1	InChI=1S/C26H34FN3/c1-6-18-11-12-22(19(7-2)14-18)28-25-29-24-21(27)9-8-10-23(24)30(25)20-13-17(3)15-26(4,5)16-20/h8-12,14,17,20H,6-7,13,15-16H2,1-5H3,(H,28,29)	OKCOYVAZMNDUCV-UHFFFAOYSA-N	389242	US9951027, 2-54-2::US9951027, 2-54-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1800							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389242	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389242&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311160	404957863							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777886	CCc1ccc(Nc2nc3c(F)cccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)c(CC)c1	InChI=1S/C26H34FN3/c1-6-18-11-12-22(19(7-2)14-18)28-25-29-24-21(27)9-8-10-23(24)30(25)20-13-17(3)15-26(4,5)16-20/h8-12,14,17,20H,6-7,13,15-16H2,1-5H3,(H,28,29)	OKCOYVAZMNDUCV-UHFFFAOYSA-N	389242	US9951027, 2-54-2::US9951027, 2-54-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389242	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389242&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311160	404957863							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777887	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccccc12	InChI=1S/C24H28F3N3O/c1-22(2)13-17(14-23(3,4)15-22)30-20-8-6-5-7-19(20)29-21(30)28-16-9-11-18(12-10-16)31-24(25,26)27/h5-12,17H,13-15H2,1-4H3,(H,28,29)	LKTLHYFLYGMDDL-UHFFFAOYSA-N	389244	US9951027, 2-55::1-(3,3,5,5-tetramethylcyclohexyl)-N-[4-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-amine	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389244	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389244&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311228	404957864							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777888	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2c(F)cccc12	InChI=1S/C23H25F4N3O/c1-14-11-16(13-22(2,3)12-14)30-19-6-4-5-18(24)20(19)29-21(30)28-15-7-9-17(10-8-15)31-23(25,26)27/h4-10,14,16H,11-13H2,1-3H3,(H,28,29)	YVMDIWMYTMXMKK-UHFFFAOYSA-N	389245	US9951027, 2-56-1::US9951027, 2-56	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 180							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389245	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389245&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318508	404957865							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777889	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2c(F)cccc12	InChI=1S/C23H25F4N3O/c1-14-11-16(13-22(2,3)12-14)30-19-6-4-5-18(24)20(19)29-21(30)28-15-7-9-17(10-8-15)31-23(25,26)27/h4-10,14,16H,11-13H2,1-3H3,(H,28,29)	YVMDIWMYTMXMKK-UHFFFAOYSA-N	389245	US9951027, 2-56-1::US9951027, 2-56	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 340							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389245	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389245&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318508	404957865							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777890	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2c(F)cccc12	InChI=1S/C23H25F4N3O/c1-14-11-16(13-22(2,3)12-14)30-19-6-4-5-18(24)20(19)29-21(30)28-15-7-9-17(10-8-15)31-23(25,26)27/h4-10,14,16H,11-13H2,1-3H3,(H,28,29)	YVMDIWMYTMXMKK-UHFFFAOYSA-N	389247	US9951027, 2-56-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 170							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389247	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389247&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318509	404957866							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777891	CCc1ccc(Nc2nc3c(F)cccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1	InChI=1S/C24H30FN3/c1-5-17-9-11-18(12-10-17)26-23-27-22-20(25)7-6-8-21(22)28(23)19-13-16(2)14-24(3,4)15-19/h6-12,16,19H,5,13-15H2,1-4H3,(H,26,27)	FRLNUHSGQMSHBI-UHFFFAOYSA-N	389248	US9951027, 2-57	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 100.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389248	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389248&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311247	404957867							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777892	CCc1ccc(Nc2nc3c(F)cccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C24H30FN3/c1-5-17-9-11-18(12-10-17)26-23-27-22-20(25)7-6-8-21(22)28(23)19-13-16(2)14-24(3,4)15-19/h6-12,16,19H,5,13-15H2,1-4H3,(H,26,27)	FRLNUHSGQMSHBI-UHFFFAOYSA-N	389249	US9951027, 2-57-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 160							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389249	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389249&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311248	404957868							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777893	CCc1ccc(Nc2nc3c(F)cccc3n2[C@H]2C[C@H](C)CC(C)(C)C2)cc1	InChI=1S/C24H30FN3/c1-5-17-9-11-18(12-10-17)26-23-27-22-20(25)7-6-8-21(22)28(23)19-13-16(2)14-24(3,4)15-19/h6-12,16,19H,5,13-15H2,1-4H3,(H,26,27)	FRLNUHSGQMSHBI-UHFFFAOYSA-N	389250	US9951027, 2-57-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389250	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389250&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011519	404957869							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777894	CC(C)Oc1ccc(Nc2nc3c(F)cccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1	InChI=1S/C25H32FN3O/c1-16(2)30-20-11-9-18(10-12-20)27-24-28-23-21(26)7-6-8-22(23)29(24)19-13-17(3)14-25(4,5)15-19/h6-12,16-17,19H,13-15H2,1-5H3,(H,27,28)	CCBTXLPUGFSZSC-UHFFFAOYSA-N	389251	US9951027, 2-58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 190							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389251	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389251&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318197	404957870							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777895	CCCOc1ccc(Nc2nc3c(F)cccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1	InChI=1S/C25H32FN3O/c1-5-13-30-20-11-9-18(10-12-20)27-24-28-23-21(26)7-6-8-22(23)29(24)19-14-17(2)15-25(3,4)16-19/h6-12,17,19H,5,13-16H2,1-4H3,(H,27,28)	FCEMDQCBUOXRRV-UHFFFAOYSA-N	389252	US9951027, 2-59	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 260							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389252	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389252&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011520	404957871							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777896	CCCOc1ccc(Nc2nc3c(F)cccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C25H32FN3O/c1-5-13-30-20-11-9-18(10-12-20)27-24-28-23-21(26)7-6-8-22(23)29(24)19-14-17(2)15-25(3,4)16-19/h6-12,17,19H,5,13-16H2,1-4H3,(H,27,28)	FCEMDQCBUOXRRV-UHFFFAOYSA-N	389253	US9951027, 2-59-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 760							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389253	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389253&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011521	404957872							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777897	CCCOc1ccc(Nc2nc3c(F)cccc3n2[C@@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C25H32FN3O/c1-5-13-30-20-11-9-18(10-12-20)27-24-28-23-21(26)7-6-8-22(23)29(24)19-14-17(2)15-25(3,4)16-19/h6-12,17,19H,5,13-16H2,1-4H3,(H,27,28)	FCEMDQCBUOXRRV-UHFFFAOYSA-N	389254	US9951027, 2-59-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 190							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389254	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389254&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011522	404957873							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777898	CCOc1ccc(Nc2nc3ccccc3n2[C@@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C24H31N3O/c1-5-28-20-12-10-18(11-13-20)25-23-26-21-8-6-7-9-22(21)27(23)19-14-17(2)15-24(3,4)16-19/h6-13,17,19H,5,14-16H2,1-4H3,(H,25,26)	IQAROIYDXTUAPB-UHFFFAOYSA-N	389255	US9951027, 2-60	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 720							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389255	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389255&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311064	404957874							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777899	CCOc1ccc(Nc2nc3ccccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1	InChI=1S/C24H31N3O/c1-5-28-20-12-10-18(11-13-20)25-23-26-21-8-6-7-9-22(21)27(23)19-14-17(2)15-24(3,4)16-19/h6-13,17,19H,5,14-16H2,1-4H3,(H,25,26)	IQAROIYDXTUAPB-UHFFFAOYSA-N	389256	US9951027, 2-60-2::US9951027, 2-60-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 300							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389256	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389256&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311062	404957875							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777900	CCOc1ccc(Nc2nc3ccccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1	InChI=1S/C24H31N3O/c1-5-28-20-12-10-18(11-13-20)25-23-26-21-8-6-7-9-22(21)27(23)19-14-17(2)15-24(3,4)16-19/h6-13,17,19H,5,14-16H2,1-4H3,(H,25,26)	IQAROIYDXTUAPB-UHFFFAOYSA-N	389256	US9951027, 2-60-2::US9951027, 2-60-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 920							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389256	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389256&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311062	404957875							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777901	C[C@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(Br)ccc12	InChI=1S/C23H25BrF3N3O/c1-14-10-17(13-22(2,3)12-14)30-20-9-4-15(24)11-19(20)29-21(30)28-16-5-7-18(8-6-16)31-23(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,28,29)	IIZWIASSDAOJPL-UHFFFAOYSA-N	389258	US9951027, 2-61-2::US9951027, 2-61	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 180							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389258	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389258&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011523	404957876							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777902	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(Br)ccc12	InChI=1S/C23H25BrF3N3O/c1-14-10-17(13-22(2,3)12-14)30-20-9-4-15(24)11-19(20)29-21(30)28-16-5-7-18(8-6-16)31-23(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,28,29)	IIZWIASSDAOJPL-UHFFFAOYSA-N	389259	US9951027, 2-61-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 950							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389259	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389259&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310285	404957877							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777903	C[C@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(Br)ccc12	InChI=1S/C23H25BrF3N3O/c1-14-10-17(13-22(2,3)12-14)30-20-9-4-15(24)11-19(20)29-21(30)28-16-5-7-18(8-6-16)31-23(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,28,29)	IIZWIASSDAOJPL-UHFFFAOYSA-N	389258	US9951027, 2-61-2::US9951027, 2-61	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 580							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389258	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389258&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011523	404957876							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777904	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Br)ccc12	InChI=1S/C23H25BrF3N3/c1-14-10-18(13-22(2,3)12-14)30-20-9-6-16(24)11-19(20)29-21(30)28-17-7-4-15(5-8-17)23(25,26)27/h4-9,11,14,18H,10,12-13H2,1-3H3,(H,28,29)	ZXFOKWOZAGOCEZ-UHFFFAOYSA-N	389261	US9951027, 2-62	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 230							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389261	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389261&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318199	404957878							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777905	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(C)(F)F)cc2)nc2cc(Br)ccc12	InChI=1S/C24H28BrF2N3O/c1-15-11-18(14-23(2,3)13-15)30-21-10-5-16(25)12-20(21)29-22(30)28-17-6-8-19(9-7-17)31-24(4,26)27/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,28,29)	DBKOBIAKPLPIAR-UHFFFAOYSA-N	389262	US9951027, 2-63	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 860							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389262	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389262&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318350	404957879							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777906	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(CC(F)(F)F)cc2)nc2cc(Br)ccc12	InChI=1S/C24H27BrF3N3/c1-15-10-19(14-23(2,3)12-15)31-21-9-6-17(25)11-20(21)30-22(31)29-18-7-4-16(5-8-18)13-24(26,27)28/h4-9,11,15,19H,10,12-14H2,1-3H3,(H,29,30)	HTHOATBSCLXRPJ-UHFFFAOYSA-N	389263	US9951027, 2-63-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 120							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389263	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389263&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011524	404957880							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777907	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(Br)ccc12	InChI=1S/C23H25BrF3N3O/c1-14-10-17(13-22(2,3)12-14)30-20-9-4-15(24)11-19(20)29-21(30)28-16-5-7-18(8-6-16)31-23(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,28,29)	IIZWIASSDAOJPL-UHFFFAOYSA-N	389264	US9951027, 2-63-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2900							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389264	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389264&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123942665	404957881							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777908	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1 |r|	InChI=1S/C25H28F3N3O3/c1-15-11-18(14-24(2,3)13-15)31-21-10-5-16(22(32)33-4)12-20(21)30-23(31)29-17-6-8-19(9-7-17)34-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,29,30)	BUONBQRWWDSYIP-UHFFFAOYSA-N	389265	US9951027, 2-64::(+-) methyl 2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylate	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 300							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389265	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389265&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310975	404957882							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777909	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C25H28F3N3O3/c1-15-11-18(14-24(2,3)13-15)31-21-10-5-16(22(32)33-4)12-20(21)30-23(31)29-17-6-8-19(9-7-17)34-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,29,30)	BUONBQRWWDSYIP-UHFFFAOYSA-N	389266	US9951027, 2-64-2::US9951027, 2-64-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 980							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389266	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389266&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310975	404957883							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777910	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C25H28F3N3O3/c1-15-11-18(14-24(2,3)13-15)31-21-10-5-16(22(32)33-4)12-20(21)30-23(31)29-17-6-8-19(9-7-17)34-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,29,30)	BUONBQRWWDSYIP-UHFFFAOYSA-N	389266	US9951027, 2-64-2::US9951027, 2-64-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 460							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389266	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389266&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310975	404957883							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777911	CCc1ccc(Nc2nc3cc(ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)C(=O)OC)cc1	InChI=1S/C26H33N3O2/c1-6-18-7-10-20(11-8-18)27-25-28-22-14-19(24(30)31-5)9-12-23(22)29(25)21-13-17(2)15-26(3,4)16-21/h7-12,14,17,21H,6,13,15-16H2,1-5H3,(H,27,28)	XUZVBMJUPMBRAF-UHFFFAOYSA-N	389268	US9951027, 2-65	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389268	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389268&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318201	404957884							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777912	COC(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C27H35N3O2/c1-17(2)19-7-10-21(11-8-19)28-26-29-23-14-20(25(31)32-6)9-12-24(23)30(26)22-13-18(3)15-27(4,5)16-22/h7-12,14,17-18,22H,13,15-16H2,1-6H3,(H,28,29)	AXRFMMNYIXZSHM-UHFFFAOYSA-N	389269	US9951027, 2-66-2::US9951027, 2-66	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 180							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389269	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389269&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318395	404957885							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777913	COC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C27H35N3O2/c1-17(2)19-7-10-21(11-8-19)28-26-29-23-14-20(25(31)32-6)9-12-24(23)30(26)22-13-18(3)15-27(4,5)16-22/h7-12,14,17-18,22H,13,15-16H2,1-6H3,(H,28,29)	AXRFMMNYIXZSHM-UHFFFAOYSA-N	389270	US9951027, 2-66-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 730							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389270	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389270&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318396	404957886							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777914	COC(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C27H35N3O2/c1-17(2)19-7-10-21(11-8-19)28-26-29-23-14-20(25(31)32-6)9-12-24(23)30(26)22-13-18(3)15-27(4,5)16-22/h7-12,14,17-18,22H,13,15-16H2,1-6H3,(H,28,29)	AXRFMMNYIXZSHM-UHFFFAOYSA-N	389269	US9951027, 2-66-2::US9951027, 2-66	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 100.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389269	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389269&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318395	404957885							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777915	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C(O)=O	InChI=1S/C24H26F3N3O3/c1-14-10-17(13-23(2,3)12-14)30-20-11-15(21(31)32)4-9-19(20)29-22(30)28-16-5-7-18(8-6-16)33-24(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,28,29)(H,31,32)	VLZXUTRARUWCKN-UHFFFAOYSA-N	389272	US9951027, 2-67	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 370							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389272	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389272&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130363781	404957887							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777916	CC(C)Oc1ccc(Nc2nc3ccc(cc3n2C2C[C@H](C)CC(C)(C)C2)C(O)=O)cc1 |r|	InChI=1S/C26H33N3O3/c1-16(2)32-21-9-7-19(8-10-21)27-25-28-22-11-6-18(24(30)31)13-23(22)29(25)20-12-17(3)14-26(4,5)15-20/h6-11,13,16-17,20H,12,14-15H2,1-5H3,(H,27,28)(H,30,31)	KPFDODFELJRZKY-UHFFFAOYSA-N	389273	US9951027, 2-68	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 750							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389273	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389273&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011525	404957888							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777917	COC(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3C[C@@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C25H28F3N3O3/c1-15-11-18(14-24(2,3)13-15)31-21-12-16(22(32)33-4)5-10-20(21)30-23(31)29-17-6-8-19(9-7-17)34-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,29,30)	HQLJGKDTIHKATM-UHFFFAOYSA-N	389274	US9951027, 2-73-1::US9951027, 2-69	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 600							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389274	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389274&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011526	404957889							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777918	COC(=O)c1ccc2nc(Nc3ccc(cc3)N(C)C)n(C3C[C@@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C26H34N4O2/c1-17-13-21(16-26(2,3)15-17)30-23-14-18(24(31)32-6)7-12-22(23)28-25(30)27-19-8-10-20(11-9-19)29(4)5/h7-12,14,17,21H,13,15-16H2,1-6H3,(H,27,28)	SEMWMAZYKBVIBL-UHFFFAOYSA-N	389275	US9951027, 2-70	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389275	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389275&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011527	404957890							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777919	COC(=O)c1ccc2nc(Nc3ccc(cc3)N(C)C)n(C3C[C@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C26H34N4O2/c1-17-13-21(16-26(2,3)15-17)30-23-14-18(24(31)32-6)7-12-22(23)28-25(30)27-19-8-10-20(11-9-19)29(4)5/h7-12,14,17,21H,13,15-16H2,1-6H3,(H,27,28)	SEMWMAZYKBVIBL-UHFFFAOYSA-N	389276	US9951027, 2-70-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389276	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389276&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011528	404957891							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777920	COC(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3C[C@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C25H28F3N3O3/c1-15-11-18(14-24(2,3)13-15)31-21-12-16(22(32)33-4)5-10-20(21)30-23(31)29-17-6-8-19(9-7-17)34-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,29,30)	HQLJGKDTIHKATM-UHFFFAOYSA-N	389277	US9951027, 2-73-2::US9951027, 2-73::US9951027, 2-70-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 140							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389277	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389277&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011529	404957892							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777921	COC(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2c1	InChI=1S/C26H30F3N3O3/c1-24(2)13-18(14-25(3,4)15-24)32-21-12-16(22(33)34-5)6-11-20(21)31-23(32)30-17-7-9-19(10-8-17)35-26(27,28)29/h6-12,18H,13-15H2,1-5H3,(H,30,31)	ZULJPQUAXCCPKV-UHFFFAOYSA-N	389278	US9951027, 2-72	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 190							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389278	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389278&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011530	404957893							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777922	COC(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3C[C@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C25H28F3N3O3/c1-15-11-18(14-24(2,3)13-15)31-21-12-16(22(32)33-4)5-10-20(21)30-23(31)29-17-6-8-19(9-7-17)34-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,29,30)	HQLJGKDTIHKATM-UHFFFAOYSA-N	389277	US9951027, 2-73-2::US9951027, 2-73::US9951027, 2-70-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 160							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389277	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389277&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011529	404957892							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777923	COC(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3C[C@@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C25H28F3N3O3/c1-15-11-18(14-24(2,3)13-15)31-21-12-16(22(32)33-4)5-10-20(21)30-23(31)29-17-6-8-19(9-7-17)34-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,29,30)	HQLJGKDTIHKATM-UHFFFAOYSA-N	389274	US9951027, 2-73-1::US9951027, 2-69	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 4900							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389274	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389274&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011526	404957889							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777924	COC(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3C[C@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C25H28F3N3O3/c1-15-11-18(14-24(2,3)13-15)31-21-12-16(22(32)33-4)5-10-20(21)30-23(31)29-17-6-8-19(9-7-17)34-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,29,30)	HQLJGKDTIHKATM-UHFFFAOYSA-N	389277	US9951027, 2-73-2::US9951027, 2-73::US9951027, 2-70-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 490							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389277	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389277&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011529	404957892							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777925	CCOC(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3C[C@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C26H30F3N3O3/c1-5-34-23(33)17-6-11-21-22(13-17)32(19-12-16(2)14-25(3,4)15-19)24(31-21)30-18-7-9-20(10-8-18)35-26(27,28)29/h6-11,13,16,19H,5,12,14-15H2,1-4H3,(H,30,31)	WEBPEUBZUGHDMV-UHFFFAOYSA-N	389282	US9951027, 2-74-1::US9951027, 2-74	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 360							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389282	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389282&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011531	404957894							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777926	CCOC(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3C[C@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C26H30F3N3O3/c1-5-34-23(33)17-6-11-21-22(13-17)32(19-12-16(2)14-25(3,4)15-19)24(31-21)30-18-7-9-20(10-8-18)35-26(27,28)29/h6-11,13,16,19H,5,12,14-15H2,1-4H3,(H,30,31)	WEBPEUBZUGHDMV-UHFFFAOYSA-N	389282	US9951027, 2-74-1::US9951027, 2-74	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1400							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389282	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389282&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011531	404957894							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777927	CCOC(=O)c1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3C[C@@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C26H30F3N3O3/c1-5-34-23(33)17-6-11-21-22(13-17)32(19-12-16(2)14-25(3,4)15-19)24(31-21)30-18-7-9-20(10-8-18)35-26(27,28)29/h6-11,13,16,19H,5,12,14-15H2,1-4H3,(H,30,31)	WEBPEUBZUGHDMV-UHFFFAOYSA-N	389284	US9951027, 2-74-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 110							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389284	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389284&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011532	404957895							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777928	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(O)=O |r|	InChI=1S/C24H26F3N3O3/c1-14-10-17(13-23(2,3)12-14)30-20-9-4-15(21(31)32)11-19(20)29-22(30)28-16-5-7-18(8-6-16)33-24(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,28,29)(H,31,32)	CNNGWPABWSPMPW-UHFFFAOYSA-N	389285	US9951027, 2-75::(+-) 2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylic acid	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 50.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389285	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389285&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318454	404957896							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777929	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(O)=O	InChI=1S/C24H26F3N3O3/c1-14-10-17(13-23(2,3)12-14)30-20-9-4-15(21(31)32)11-19(20)29-22(30)28-16-5-7-18(8-6-16)33-24(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,28,29)(H,31,32)	CNNGWPABWSPMPW-UHFFFAOYSA-N	389223	US9951027, 2-75-1::US9951027, 2-75-2::US9951027, 2-81-1::US9951027, 2-42-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389223	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389223&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318454	404957848							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777930	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(O)=O	InChI=1S/C24H26F3N3O3/c1-14-10-17(13-23(2,3)12-14)30-20-9-4-15(21(31)32)11-19(20)29-22(30)28-16-5-7-18(8-6-16)33-24(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,28,29)(H,31,32)	CNNGWPABWSPMPW-UHFFFAOYSA-N	389223	US9951027, 2-75-1::US9951027, 2-75-2::US9951027, 2-81-1::US9951027, 2-42-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389223	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389223&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318454	404957848							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777931	CC(C)c1ccc(Nc2nc3cc(ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)C(O)=O)cc1 |r|	InChI=1S/C26H33N3O2/c1-16(2)18-6-9-20(10-7-18)27-25-28-22-13-19(24(30)31)8-11-23(22)29(25)21-12-17(3)14-26(4,5)15-21/h6-11,13,16-17,21H,12,14-15H2,1-5H3,(H,27,28)(H,30,31)	GWMNDWCQEWDFPA-UHFFFAOYSA-N	389288	US9951027, 2-76	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389288	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389288&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311082	404957897							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777932	C[C@@H]1C[C@@H](CC(C1)(C)C)n2c3ccc(cc3nc2Nc4ccc(cc4)C(C)C)C(=O)O	InChI=1S/C26H33N3O2/c1-16(2)18-6-9-20(10-7-18)27-25-28-22-13-19(24(30)31)8-11-23(22)29(25)21-12-17(3)14-26(4,5)15-21/h6-11,13,16-17,21H,12,14-15H2,1-5H3,(H,27,28)(H,30,31)	GWMNDWCQEWDFPA-UHFFFAOYSA-N	389289	US9951027, 2-76-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389289	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389289&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	6VN	5LGE	118311107	404957898							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777933	CC(C)c1ccc(Nc2nc3cc(ccc3n2[C@H]2C[C@H](C)CC(C)(C)C2)C(O)=O)cc1	InChI=1S/C26H33N3O2/c1-16(2)18-6-9-20(10-7-18)27-25-28-22-13-19(24(30)31)8-11-23(22)29(25)21-12-17(3)14-26(4,5)15-21/h6-11,13,16-17,21H,12,14-15H2,1-5H3,(H,27,28)(H,30,31)	GWMNDWCQEWDFPA-UHFFFAOYSA-N	389290	US9951027, 2-76-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 4.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389290	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389290&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011533	404957899							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777934	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(ccc12)C(O)=O |r|	InChI=1S/C24H26F3N3O2/c1-14-10-18(13-23(2,3)12-14)30-20-9-4-15(21(31)32)11-19(20)29-22(30)28-17-7-5-16(6-8-17)24(25,26)27/h4-9,11,14,18H,10,12-13H2,1-3H3,(H,28,29)(H,31,32)	WAURALNZJQSVOK-UHFFFAOYSA-N	389291	US9951027, 2-77	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389291	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389291&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130201994	404957900							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777935	CC(C)Oc1ccc(Nc2nc3cc(ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)C(O)=O)cc1 |r|	InChI=1S/C26H33N3O3/c1-16(2)32-21-9-7-19(8-10-21)27-25-28-22-13-18(24(30)31)6-11-23(22)29(25)20-12-17(3)14-26(4,5)15-20/h6-11,13,16-17,20H,12,14-15H2,1-5H3,(H,27,28)(H,30,31)	ISFPPYOFQGYEDE-UHFFFAOYSA-N	389292	US9951027, 2-78	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 180							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389292	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389292&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318207	404957901							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777936	C[C@@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(O)=O |r|	InChI=1S/C24H26F3N3O3/c1-14-10-17(13-23(2,3)12-14)30-20-9-4-15(21(31)32)11-19(20)29-22(30)28-16-5-7-18(8-6-16)33-24(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,28,29)(H,31,32)	CNNGWPABWSPMPW-UHFFFAOYSA-N	389293	US9951027, 2-80	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 150							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389293	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389293&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318512	404957902							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777937	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(O)=O)c(Cl)cc12 |r|	InChI=1S/C24H25ClF3N3O3/c1-13-8-15(12-23(2,3)11-13)31-20-10-18(25)17(21(32)33)9-19(20)30-22(31)29-14-4-6-16(7-5-14)34-24(26,27)28/h4-7,9-10,13,15H,8,11-12H2,1-3H3,(H,29,30)(H,32,33)	MKTONEOSUUOGKR-UHFFFAOYSA-N	389294	US9951027, 2-81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389294	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389294&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318551	404957903							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777938	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(O)=O	InChI=1S/C24H26F3N3O3/c1-14-10-17(13-23(2,3)12-14)30-20-9-4-15(21(31)32)11-19(20)29-22(30)28-16-5-7-18(8-6-16)33-24(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,28,29)(H,31,32)	CNNGWPABWSPMPW-UHFFFAOYSA-N	389223	US9951027, 2-75-1::US9951027, 2-75-2::US9951027, 2-81-1::US9951027, 2-42-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 130							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389223	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389223&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318454	404957848							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777939	C[C@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(O)=O	InChI=1S/C24H26F3N3O3/c1-14-10-17(13-23(2,3)12-14)30-20-9-4-15(21(31)32)11-19(20)29-22(30)28-16-5-7-18(8-6-16)33-24(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,28,29)(H,31,32)	CNNGWPABWSPMPW-UHFFFAOYSA-N	389296	US9951027, 2-81-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389296	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389296&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318553	404957904							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777940	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(O)=O)c(F)cc12 |r|	InChI=1S/C24H25F4N3O3/c1-13-8-15(12-23(2,3)11-13)31-20-10-18(25)17(21(32)33)9-19(20)30-22(31)29-14-4-6-16(7-5-14)34-24(26,27)28/h4-7,9-10,13,15H,8,11-12H2,1-3H3,(H,29,30)(H,32,33)	AXMVNYPGXCQZPZ-UHFFFAOYSA-N	389297	US9951027, 2-82	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389297	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389297&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310980	404957905							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777941	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(O)=O)c(F)cc12	InChI=1S/C24H25F4N3O3/c1-13-8-15(12-23(2,3)11-13)31-20-10-18(25)17(21(32)33)9-19(20)30-22(31)29-14-4-6-16(7-5-14)34-24(26,27)28/h4-7,9-10,13,15H,8,11-12H2,1-3H3,(H,29,30)(H,32,33)	AXMVNYPGXCQZPZ-UHFFFAOYSA-N	389298	US9951027, 2-82-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 250							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389298	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389298&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318218	404957906							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777942	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(O)=O)c(F)cc12	InChI=1S/C24H25F4N3O3/c1-13-8-15(12-23(2,3)11-13)31-20-10-18(25)17(21(32)33)9-19(20)30-22(31)29-14-4-6-16(7-5-14)34-24(26,27)28/h4-7,9-10,13,15H,8,11-12H2,1-3H3,(H,29,30)(H,32,33)	AXMVNYPGXCQZPZ-UHFFFAOYSA-N	389299	US9951027, 2-82-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 90.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389299	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389299&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310980	404957907							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777943	CNC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1 |r|	InChI=1S/C25H29F3N4O2/c1-15-11-18(14-24(2,3)13-15)32-21-10-5-16(22(33)29-4)12-20(21)31-23(32)30-17-6-8-19(9-7-17)34-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,29,33)(H,30,31)	RLQSDFBIEVLYCF-UHFFFAOYSA-N	389300	US9951027, 2-83::(+-) N-methyl-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxamide	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 220							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389300	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389300&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318214	404957908							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777944	CCc1ccc(Nc2nc3cc(ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)C(=O)NCCO)cc1 |r|	InChI=1S/C27H36N4O2/c1-5-19-6-9-21(10-7-19)29-26-30-23-15-20(25(33)28-12-13-32)8-11-24(23)31(26)22-14-18(2)16-27(3,4)17-22/h6-11,15,18,22,32H,5,12-14,16-17H2,1-4H3,(H,28,33)(H,29,30)	GUYZDDPQIYXTKN-UHFFFAOYSA-N	389301	US9951027, 2-84::(+-) 2-[(4-ethylphenyl)amino]-N-(2-hydroxyethyl)-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxamide	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 130							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389301	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389301&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318397	404957909					C04080		1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777945	C[C@@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(=O)N(C)C	InChI=1S/C26H31F3N4O2/c1-16-12-19(15-25(2,3)14-16)33-22-11-6-17(23(34)32(4)5)13-21(22)31-24(33)30-18-7-9-20(10-8-18)35-26(27,28)29/h6-11,13,16,19H,12,14-15H2,1-5H3,(H,30,31)	ZAFJKDIILACEBH-UHFFFAOYSA-N	389302	US9951027, 2-85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 170							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389302	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389302&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318559	404957910							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777946	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(=O)N(C)C	InChI=1S/C26H31F3N4O2/c1-16-12-19(15-25(2,3)14-16)33-22-11-6-17(23(34)32(4)5)13-21(22)31-24(33)30-18-7-9-20(10-8-18)35-26(27,28)29/h6-11,13,16,19H,12,14-15H2,1-5H3,(H,30,31)	ZAFJKDIILACEBH-UHFFFAOYSA-N	389303	US9951027, 2-86	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389303	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389303&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318560	404957911							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777947	C[C@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(=O)N(C)C	InChI=1S/C26H31F3N4O2/c1-16-12-19(15-25(2,3)14-16)33-22-11-6-17(23(34)32(4)5)13-21(22)31-24(33)30-18-7-9-20(10-8-18)35-26(27,28)29/h6-11,13,16,19H,12,14-15H2,1-5H3,(H,30,31)	ZAFJKDIILACEBH-UHFFFAOYSA-N	389304	US9951027, 2-86-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389304	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389304&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318561	404957912							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777948	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(=O)N(C)C	InChI=1S/C26H31F3N4O2/c1-16-12-19(15-25(2,3)14-16)33-22-11-6-17(23(34)32(4)5)13-21(22)31-24(33)30-18-7-9-20(10-8-18)35-26(27,28)29/h6-11,13,16,19H,12,14-15H2,1-5H3,(H,30,31)	ZAFJKDIILACEBH-UHFFFAOYSA-N	389305	US9951027, 2-86-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389305	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389305&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318562	404957913							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777949	CCc1ccc(Nc2nc3cc(ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)C(=O)NC)cc1	InChI=1S/C26H34N4O/c1-6-18-7-10-20(11-8-18)28-25-29-22-14-19(24(31)27-5)9-12-23(22)30(25)21-13-17(2)15-26(3,4)16-21/h7-12,14,17,21H,6,13,15-16H2,1-5H3,(H,27,31)(H,28,29)	UUNQAMMFDSRPKK-UHFFFAOYSA-N	389306	US9951027, 2-87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 240							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389306	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389306&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130210221	404957914							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777950	CCc1ccc(Nc2nc3cc(ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)C(=O)NC)cc1	InChI=1S/C26H34N4O/c1-6-18-7-10-20(11-8-18)28-25-29-22-14-19(24(31)27-5)9-12-23(22)30(25)21-13-17(2)15-26(3,4)16-21/h7-12,14,17,21H,6,13,15-16H2,1-5H3,(H,27,31)(H,28,29)	UUNQAMMFDSRPKK-UHFFFAOYSA-N	389307	US9951027, 2-87-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 130							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389307	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389307&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130210220	404957915							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777951	CCc1ccc(Nc2nc3cc(ccc3n2[C@H]2C[C@H](C)CC(C)(C)C2)C(=O)NC)cc1	InChI=1S/C26H34N4O/c1-6-18-7-10-20(11-8-18)28-25-29-22-14-19(24(31)27-5)9-12-23(22)30(25)21-13-17(2)15-26(3,4)16-21/h7-12,14,17,21H,6,13,15-16H2,1-5H3,(H,27,31)(H,28,29)	UUNQAMMFDSRPKK-UHFFFAOYSA-N	389308	US9951027, 2-87-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 460							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389308	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389308&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011534	404957916							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777952	C[C@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(=O)NCCO	InChI=1S/C26H31F3N4O3/c1-16-12-19(15-25(2,3)14-16)33-22-9-4-17(23(35)30-10-11-34)13-21(22)32-24(33)31-18-5-7-20(8-6-18)36-26(27,28)29/h4-9,13,16,19,34H,10-12,14-15H2,1-3H3,(H,30,35)(H,31,32)	XIMBMCOXJVGWRP-UHFFFAOYSA-N	389309	US9951027, 2-88-2::US9951027, 2-88	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 180							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389309	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389309&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011535	404957917					C04080		1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777953	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(=O)NCCO	InChI=1S/C26H31F3N4O3/c1-16-12-19(15-25(2,3)14-16)33-22-9-4-17(23(35)30-10-11-34)13-21(22)32-24(33)31-18-5-7-20(8-6-18)36-26(27,28)29/h4-9,13,16,19,34H,10-12,14-15H2,1-3H3,(H,30,35)(H,31,32)	XIMBMCOXJVGWRP-UHFFFAOYSA-N	389310	US9951027, 2-88-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1800							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389310	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389310&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130201966	404957918					C04080		1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777954	C[C@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(=O)NCCO	InChI=1S/C26H31F3N4O3/c1-16-12-19(15-25(2,3)14-16)33-22-9-4-17(23(35)30-10-11-34)13-21(22)32-24(33)31-18-5-7-20(8-6-18)36-26(27,28)29/h4-9,13,16,19,34H,10-12,14-15H2,1-3H3,(H,30,35)(H,31,32)	XIMBMCOXJVGWRP-UHFFFAOYSA-N	389309	US9951027, 2-88-2::US9951027, 2-88	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 400							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389309	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389309&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011535	404957917					C04080		1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777955	CCNC(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C26H31F3N4O2/c1-5-30-23(34)17-6-11-22-21(13-17)32-24(33(22)19-12-16(2)14-25(3,4)15-19)31-18-7-9-20(10-8-18)35-26(27,28)29/h6-11,13,16,19H,5,12,14-15H2,1-4H3,(H,30,34)(H,31,32)	GWRRBOOQDCZMHX-UHFFFAOYSA-N	389312	US9951027, 2-89	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 210							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389312	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389312&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318353	404957919							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777956	CCc1ccc(Nc2nc3cc(ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)C(=O)N2CCCCC2)cc1	InChI=1S/C30H40N4O/c1-5-22-9-12-24(13-10-22)31-29-32-26-18-23(28(35)33-15-7-6-8-16-33)11-14-27(26)34(29)25-17-21(2)19-30(3,4)20-25/h9-14,18,21,25H,5-8,15-17,19-20H2,1-4H3,(H,31,32)	LBHVUNCCAXCQJM-UHFFFAOYSA-N	389313	US9951027, 2-90	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 180							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389313	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389313&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311085	404957920							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777957	CCc1ccc(Nc2nc3cc(ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)C(=O)N(C)C)cc1	InChI=1S/C27H36N4O/c1-7-19-8-11-21(12-9-19)28-26-29-23-15-20(25(32)30(5)6)10-13-24(23)31(26)22-14-18(2)16-27(3,4)17-22/h8-13,15,18,22H,7,14,16-17H2,1-6H3,(H,28,29)	UUVRQFXUFLOILN-UHFFFAOYSA-N	389314	US9951027, 2-91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 380							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389314	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389314&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318513	404957921							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777958	CCc1ccc(Nc2nc3cc(ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)C(=O)N(C)C)cc1	InChI=1S/C27H36N4O/c1-7-19-8-11-21(12-9-19)28-26-29-23-15-20(25(32)30(5)6)10-13-24(23)31(26)22-14-18(2)16-27(3,4)17-22/h8-13,15,18,22H,7,14,16-17H2,1-6H3,(H,28,29)	UUVRQFXUFLOILN-UHFFFAOYSA-N	389315	US9951027, 2-91-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389315	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389315&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318455	404957922							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777959	CCc1ccc(Nc2nc3cc(ccc3n2[C@@H]2C[C@@H](C)CC(C)(C)C2)C(=O)N(C)C)cc1	InChI=1S/C27H36N4O/c1-7-19-8-11-21(12-9-19)28-26-29-23-15-20(25(32)30(5)6)10-13-24(23)31(26)22-14-18(2)16-27(3,4)17-22/h8-13,15,18,22H,7,14,16-17H2,1-6H3,(H,28,29)	UUVRQFXUFLOILN-UHFFFAOYSA-N	389316	US9951027, 2-91-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389316	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389316&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011536	404957923							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777960	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(=O)NCC(O)=O	InChI=1S/C26H29F3N4O4/c1-15-10-18(13-25(2,3)12-15)33-21-9-4-16(23(36)30-14-22(34)35)11-20(21)32-24(33)31-17-5-7-19(8-6-17)37-26(27,28)29/h4-9,11,15,18H,10,12-14H2,1-3H3,(H,30,36)(H,31,32)(H,34,35)	MDYJTYUZGOLXRO-UHFFFAOYSA-N	389317	US9951027, 2-92-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 100.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389317	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389317&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311196	404957924							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777961	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(=O)NCC(O)=O	InChI=1S/C26H29F3N4O4/c1-15-10-18(13-25(2,3)12-15)33-21-9-4-16(23(36)30-14-22(34)35)11-20(21)32-24(33)31-17-5-7-19(8-6-17)37-26(27,28)29/h4-9,11,15,18H,10,12-14H2,1-3H3,(H,30,36)(H,31,32)(H,34,35)	MDYJTYUZGOLXRO-UHFFFAOYSA-N	389318	US9951027, 2-92-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389318	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389318&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311206	404957925							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777962	C[C@@H](NC(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1)C(O)=O	InChI=1S/C27H31F3N4O4/c1-15-11-19(14-26(3,4)13-15)34-22-10-5-17(23(35)31-16(2)24(36)37)12-21(22)33-25(34)32-18-6-8-20(9-7-18)38-27(28,29)30/h5-10,12,15-16,19H,11,13-14H2,1-4H3,(H,31,35)(H,32,33)(H,36,37)	DRRDDZZRKJFWMB-UHFFFAOYSA-N	389319	US9951027, 2-93-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 270							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389319	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389319&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311108	404957926							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777963	C[C@@H](NC(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1)C(O)=O	InChI=1S/C27H31F3N4O4/c1-15-11-19(14-26(3,4)13-15)34-22-10-5-17(23(35)31-16(2)24(36)37)12-21(22)33-25(34)32-18-6-8-20(9-7-18)38-27(28,29)30/h5-10,12,15-16,19H,11,13-14H2,1-4H3,(H,31,35)(H,32,33)(H,36,37)	DRRDDZZRKJFWMB-UHFFFAOYSA-N	389320	US9951027, 2-93-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 110							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389320	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389320&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311188	404957927							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777964	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(=O)NCCC(O)=O	InChI=1S/C27H31F3N4O4/c1-16-12-19(15-26(2,3)14-16)34-22-9-4-17(24(37)31-11-10-23(35)36)13-21(22)33-25(34)32-18-5-7-20(8-6-18)38-27(28,29)30/h4-9,13,16,19H,10-12,14-15H2,1-3H3,(H,31,37)(H,32,33)(H,35,36)	MVWAGDGERSGKKD-UHFFFAOYSA-N	389321	US9951027, 2-94-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 750							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389321	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389321&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318515	404957928							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777965	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(=O)NCCC(O)=O	InChI=1S/C27H31F3N4O4/c1-16-12-19(15-26(2,3)14-16)34-22-9-4-17(24(37)31-11-10-23(35)36)13-21(22)33-25(34)32-18-5-7-20(8-6-18)38-27(28,29)30/h4-9,13,16,19H,10-12,14-15H2,1-3H3,(H,31,37)(H,32,33)(H,35,36)	MVWAGDGERSGKKD-UHFFFAOYSA-N	389322	US9951027, 2-94-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389322	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389322&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318514	404957929							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777966	COC(=O)[C@H](C)N(C)C(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C29H35F3N4O4/c1-17-13-21(16-28(3,4)15-17)36-24-12-7-19(25(37)35(5)18(2)26(38)39-6)14-23(24)34-27(36)33-20-8-10-22(11-9-20)40-29(30,31)32/h7-12,14,17-18,21H,13,15-16H2,1-6H3,(H,33,34)	IUVKCQDNXHVVJO-UHFFFAOYSA-N	389323	US9951027, 2-96-1::US9951027, 2-95-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 310							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389323	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389323&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311046	404957930							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777967	COC(=O)[C@H](C)N(C)C(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C29H35F3N4O4/c1-17-13-21(16-28(3,4)15-17)36-24-12-7-19(25(37)35(5)18(2)26(38)39-6)14-23(24)34-27(36)33-20-8-10-22(11-9-20)40-29(30,31)32/h7-12,14,17-18,21H,13,15-16H2,1-6H3,(H,33,34)	IUVKCQDNXHVVJO-UHFFFAOYSA-N	389324	US9951027, 2-96-2::US9951027, 2-95-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 110							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389324	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389324&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311221	404957931							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777968	COC(=O)[C@H](C)N(C)C(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C29H35F3N4O4/c1-17-13-21(16-28(3,4)15-17)36-24-12-7-19(25(37)35(5)18(2)26(38)39-6)14-23(24)34-27(36)33-20-8-10-22(11-9-20)40-29(30,31)32/h7-12,14,17-18,21H,13,15-16H2,1-6H3,(H,33,34)	IUVKCQDNXHVVJO-UHFFFAOYSA-N	389323	US9951027, 2-96-1::US9951027, 2-95-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389323	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389323&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311046	404957930							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777969	COC(=O)[C@H](C)N(C)C(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C29H35F3N4O4/c1-17-13-21(16-28(3,4)15-17)36-24-12-7-19(25(37)35(5)18(2)26(38)39-6)14-23(24)34-27(36)33-20-8-10-22(11-9-20)40-29(30,31)32/h7-12,14,17-18,21H,13,15-16H2,1-6H3,(H,33,34)	IUVKCQDNXHVVJO-UHFFFAOYSA-N	389324	US9951027, 2-96-2::US9951027, 2-95-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 4.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389324	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389324&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311221	404957931							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777970	COC(=O)[C@H](C)N(C)C(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1Cl	InChI=1S/C29H34ClF3N4O4/c1-16-11-19(15-28(3,4)14-16)37-24-13-22(30)21(25(38)36(5)17(2)26(39)40-6)12-23(24)35-27(37)34-18-7-9-20(10-8-18)41-29(31,32)33/h7-10,12-13,16-17,19H,11,14-15H2,1-6H3,(H,34,35)	KEMNMLXQBZJXCF-UHFFFAOYSA-N	389327	US9951027, 2-97	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 280							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389327	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389327&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311146	404957932							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777971	COC(=O)[C@H](C)N(C)C(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1Cl	InChI=1S/C29H34ClF3N4O4/c1-16-11-19(15-28(3,4)14-16)37-24-13-22(30)21(25(38)36(5)17(2)26(39)40-6)12-23(24)35-27(37)34-18-7-9-20(10-8-18)41-29(31,32)33/h7-10,12-13,16-17,19H,11,14-15H2,1-6H3,(H,34,35)	KEMNMLXQBZJXCF-UHFFFAOYSA-N	389328	US9951027, 2-98	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 130							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389328	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389328&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311162	404957933							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777972	C[C@H](NC(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1Cl)C(O)=O	InChI=1S/C27H30ClF3N4O4/c1-14-9-17(13-26(3,4)12-14)35-22-11-20(28)19(23(36)32-15(2)24(37)38)10-21(22)34-25(35)33-16-5-7-18(8-6-16)39-27(29,30)31/h5-8,10-11,14-15,17H,9,12-13H2,1-4H3,(H,32,36)(H,33,34)(H,37,38)	NIOBTTUDLICVOY-UHFFFAOYSA-N	389329	US9951027, 2-99-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 790							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389329	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389329&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318518	404957934							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777973	C[C@H](NC(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1Cl)C(O)=O	InChI=1S/C27H30ClF3N4O4/c1-14-9-17(13-26(3,4)12-14)35-22-11-20(28)19(23(36)32-15(2)24(37)38)10-21(22)34-25(35)33-16-5-7-18(8-6-16)39-27(29,30)31/h5-8,10-11,14-15,17H,9,12-13H2,1-4H3,(H,32,36)(H,33,34)(H,37,38)	NIOBTTUDLICVOY-UHFFFAOYSA-N	389330	US9951027, 2-99-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 180							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389330	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389330&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318520	404957935							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777974	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(=O)N(C)CC(O)=O)c(Cl)cc12	InChI=1S/C27H30ClF3N4O4/c1-15-9-17(13-26(2,3)12-15)35-22-11-20(28)19(24(38)34(4)14-23(36)37)10-21(22)33-25(35)32-16-5-7-18(8-6-16)39-27(29,30)31/h5-8,10-11,15,17H,9,12-14H2,1-4H3,(H,32,33)(H,36,37)	XASMFKQZEMWTQJ-UHFFFAOYSA-N	389331	US9951027, 2-103::US9951027, 2-100	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389331	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389331&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318399	404957936							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777975	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(=O)N(C)CC(O)=O)c(Cl)cc12	InChI=1S/C27H30ClF3N4O4/c1-15-9-17(13-26(2,3)12-15)35-22-11-20(28)19(24(38)34(4)14-23(36)37)10-21(22)33-25(35)32-16-5-7-18(8-6-16)39-27(29,30)31/h5-8,10-11,15,17H,9,12-14H2,1-4H3,(H,32,33)(H,36,37)	XASMFKQZEMWTQJ-UHFFFAOYSA-N	389332	US9951027, 2-101-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 90.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389332	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389332&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318398	404957937							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777976	C[C@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(=O)N(C)CC(O)=O)c(Cl)cc12	InChI=1S/C27H30ClF3N4O4/c1-15-9-17(13-26(2,3)12-15)35-22-11-20(28)19(24(38)34(4)14-23(36)37)10-21(22)33-25(35)32-16-5-7-18(8-6-16)39-27(29,30)31/h5-8,10-11,15,17H,9,12-14H2,1-4H3,(H,32,33)(H,36,37)	XASMFKQZEMWTQJ-UHFFFAOYSA-N	389333	US9951027, 2-101-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389333	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389333&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011537	404957938							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777977	C[C@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(=O)N(C)C(O)=O)c(Cl)cc12	InChI=1S/C26H28ClF3N4O4/c1-14-9-16(13-25(2,3)12-14)34-21-11-19(27)18(22(35)33(4)24(36)37)10-20(21)32-23(34)31-15-5-7-17(8-6-15)38-26(28,29)30/h5-8,10-11,14,16H,9,12-13H2,1-4H3,(H,31,32)(H,36,37)	RZINNNPVGBOLQA-UHFFFAOYSA-N	389334	US9951027, 2-102	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389334	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389334&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011538	404957939							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777978	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(=O)N(C)C(O)=O)c(Cl)cc12	InChI=1S/C26H28ClF3N4O4/c1-14-9-16(13-25(2,3)12-14)34-21-11-19(27)18(22(35)33(4)24(36)37)10-20(21)32-23(34)31-15-5-7-17(8-6-15)38-26(28,29)30/h5-8,10-11,14,16H,9,12-13H2,1-4H3,(H,31,32)(H,36,37)	RZINNNPVGBOLQA-UHFFFAOYSA-N	389335	US9951027, 2-102-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 180							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389335	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389335&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011539	404957940							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777979	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(=O)N(C)C(O)=O)c(Cl)cc12	InChI=1S/C26H28ClF3N4O4/c1-14-9-16(13-25(2,3)12-14)34-21-11-19(27)18(22(35)33(4)24(36)37)10-20(21)32-23(34)31-15-5-7-17(8-6-15)38-26(28,29)30/h5-8,10-11,14,16H,9,12-13H2,1-4H3,(H,31,32)(H,36,37)	RZINNNPVGBOLQA-UHFFFAOYSA-N	389336	US9951027, 2-102-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 6.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389336	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389336&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011540	404957941							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777980	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(=O)N(C)CC(O)=O)c(Cl)cc12	InChI=1S/C27H30ClF3N4O4/c1-15-9-17(13-26(2,3)12-15)35-22-11-20(28)19(24(38)34(4)14-23(36)37)10-21(22)33-25(35)32-16-5-7-18(8-6-16)39-27(29,30)31/h5-8,10-11,15,17H,9,12-14H2,1-4H3,(H,32,33)(H,36,37)	XASMFKQZEMWTQJ-UHFFFAOYSA-N	389331	US9951027, 2-103::US9951027, 2-100	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389331	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389331&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318399	404957936							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777981	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(=O)N(C)CC(O)=O)c(F)cc12	InChI=1S/C27H30F4N4O4/c1-15-9-17(13-26(2,3)12-15)35-22-11-20(28)19(24(38)34(4)14-23(36)37)10-21(22)33-25(35)32-16-5-7-18(8-6-16)39-27(29,30)31/h5-8,10-11,15,17H,9,12-14H2,1-4H3,(H,32,33)(H,36,37)	QTIHSWLFIWFUAS-UHFFFAOYSA-N	389338	US9951027, 2-104	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389338	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389338&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311215	404957942							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777982	C[C@@H](N(C)C(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1F)C(O)=O	InChI=1S/C28H32F4N4O4/c1-15-10-18(14-27(3,4)13-15)36-23-12-21(29)20(24(37)35(5)16(2)25(38)39)11-22(23)34-26(36)33-17-6-8-19(9-7-17)40-28(30,31)32/h6-9,11-12,15-16,18H,10,13-14H2,1-5H3,(H,33,34)(H,38,39)	FBQFVUGJRARLQG-UHFFFAOYSA-N	389339	US9951027, 2-105-2::US9951027, 2-105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389339	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389339&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011541	404957943							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777983	C[C@@H](N(C)C(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1F)C(O)=O	InChI=1S/C28H32F4N4O4/c1-15-10-18(14-27(3,4)13-15)36-23-12-21(29)20(24(37)35(5)16(2)25(38)39)11-22(23)34-26(36)33-17-6-8-19(9-7-17)40-28(30,31)32/h6-9,11-12,15-16,18H,10,13-14H2,1-5H3,(H,33,34)(H,38,39)	FBQFVUGJRARLQG-UHFFFAOYSA-N	389340	US9951027, 2-105-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 180							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389340	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389340&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011542	404957944							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777984	C[C@@H](N(C)C(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1F)C(O)=O	InChI=1S/C28H32F4N4O4/c1-15-10-18(14-27(3,4)13-15)36-23-12-21(29)20(24(37)35(5)16(2)25(38)39)11-22(23)34-26(36)33-17-6-8-19(9-7-17)40-28(30,31)32/h6-9,11-12,15-16,18H,10,13-14H2,1-5H3,(H,33,34)(H,38,39)	FBQFVUGJRARLQG-UHFFFAOYSA-N	389339	US9951027, 2-105-2::US9951027, 2-105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389339	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389339&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011541	404957943							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777985	C[C@@H](N(C)C(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1Cl)C(O)=O	InChI=1S/C28H32ClF3N4O4/c1-15-10-18(14-27(3,4)13-15)36-23-12-21(29)20(24(37)35(5)16(2)25(38)39)11-22(23)34-26(36)33-17-6-8-19(9-7-17)40-28(30,31)32/h6-9,11-12,15-16,18H,10,13-14H2,1-5H3,(H,33,34)(H,38,39)	ZWEALZUVNDGNHL-UHFFFAOYSA-N	389342	US9951027, 2-106	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 350							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389342	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389342&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011543	404957945							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777986	C[C@@H](N(C)C(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@H](C)CC(C)(C)C3)c2cc1Cl)C(O)=O	InChI=1S/C28H32ClF3N4O4/c1-15-10-18(14-27(3,4)13-15)36-23-12-21(29)20(24(37)35(5)16(2)25(38)39)11-22(23)34-26(36)33-17-6-8-19(9-7-17)40-28(30,31)32/h6-9,11-12,15-16,18H,10,13-14H2,1-5H3,(H,33,34)(H,38,39)	ZWEALZUVNDGNHL-UHFFFAOYSA-N	389343	US9951027, 2-106-2::US9951027, 2-106-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389343	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389343&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011544	404957946							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777987	C[C@@H](N(C)C(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@H](C)CC(C)(C)C3)c2cc1Cl)C(O)=O	InChI=1S/C28H32ClF3N4O4/c1-15-10-18(14-27(3,4)13-15)36-23-12-21(29)20(24(37)35(5)16(2)25(38)39)11-22(23)34-26(36)33-17-6-8-19(9-7-17)40-28(30,31)32/h6-9,11-12,15-16,18H,10,13-14H2,1-5H3,(H,33,34)(H,38,39)	ZWEALZUVNDGNHL-UHFFFAOYSA-N	389343	US9951027, 2-106-2::US9951027, 2-106-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 170							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389343	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389343&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011544	404957946							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777988	C[C@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(=O)NS(C)(=O)=O)c(Cl)cc12	InChI=1S/C25H28ClF3N4O4S/c1-14-9-16(13-24(2,3)12-14)33-21-11-19(26)18(22(34)32-38(4,35)36)10-20(21)31-23(33)30-15-5-7-17(8-6-15)37-25(27,28)29/h5-8,10-11,14,16H,9,12-13H2,1-4H3,(H,30,31)(H,32,34)	JSWQDJAOCHSOSR-UHFFFAOYSA-N	389345	US9951027, 2-107	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 110							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389345	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389345&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011545	404957947							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777989	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(=O)NS(C)(=O)=O)c(Cl)cc12	InChI=1S/C25H28ClF3N4O4S/c1-14-9-16(13-24(2,3)12-14)33-21-11-19(26)18(22(34)32-38(4,35)36)10-20(21)31-23(33)30-15-5-7-17(8-6-15)37-25(27,28)29/h5-8,10-11,14,16H,9,12-13H2,1-4H3,(H,30,31)(H,32,34)	JSWQDJAOCHSOSR-UHFFFAOYSA-N	389346	US9951027, 2-108-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389346	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389346&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311166	404957948							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777990	C[C@@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(=O)NS(C)(=O)=O)c(Cl)cc12	InChI=1S/C25H28ClF3N4O4S/c1-14-9-16(13-24(2,3)12-14)33-21-11-19(26)18(22(34)32-38(4,35)36)10-20(21)31-23(33)30-15-5-7-17(8-6-15)37-25(27,28)29/h5-8,10-11,14,16H,9,12-13H2,1-4H3,(H,30,31)(H,32,34)	JSWQDJAOCHSOSR-UHFFFAOYSA-N	389347	US9951027, 2-108-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 60.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389347	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389347&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311227	404957949							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777991	COC(=O)CN(C)C(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C28H33F3N4O4/c1-17-12-20(15-27(2,3)14-17)35-23-11-6-18(25(37)34(4)16-24(36)38-5)13-22(23)33-26(35)32-19-7-9-21(10-8-19)39-28(29,30)31/h6-11,13,17,20H,12,14-16H2,1-5H3,(H,32,33)	VNYIZNJKSRNUGA-UHFFFAOYSA-N	389348	US9951027, 2-109-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 360							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389348	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389348&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311029	404957950							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777992	COC(=O)CN(C)C(=O)c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C28H33F3N4O4/c1-17-12-20(15-27(2,3)14-17)35-23-11-6-18(25(37)34(4)16-24(36)38-5)13-22(23)33-26(35)32-19-7-9-21(10-8-19)39-28(29,30)31/h6-11,13,17,20H,12,14-16H2,1-5H3,(H,32,33)	VNYIZNJKSRNUGA-UHFFFAOYSA-N	389349	US9951027, 2-109-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389349	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389349&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311260	404957951							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777993	COC(=O)[C@H](C)N(C)C(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1F |r|	InChI=1S/C29H34F4N4O4/c1-16-11-19(15-28(3,4)14-16)37-24-13-22(30)21(25(38)36(5)17(2)26(39)40-6)12-23(24)35-27(37)34-18-7-9-20(10-8-18)41-29(31,32)33/h7-10,12-13,16-17,19H,11,14-15H2,1-6H3,(H,34,35)	IKZLHRBYXXUMPD-UHFFFAOYSA-N	389350	US9951027, 2-126::methyl N-[(6-fluoro-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)carbonyl]-N-methyl-L-alaninate	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 770							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389350	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389350&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311225	404957952							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777994	COC(=O)[C@H](C)N(C)C(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1F	InChI=1S/C29H34F4N4O4/c1-16-11-19(15-28(3,4)14-16)37-24-13-22(30)21(25(38)36(5)17(2)26(39)40-6)12-23(24)35-27(37)34-18-7-9-20(10-8-18)41-29(31,32)33/h7-10,12-13,16-17,19H,11,14-15H2,1-6H3,(H,34,35)	IKZLHRBYXXUMPD-UHFFFAOYSA-N	389351	US9951027, 2-126-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 3000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389351	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389351&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311225	404957953							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777995	COC(=O)[C@H](C)N(C)C(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1F	InChI=1S/C29H34F4N4O4/c1-16-11-19(15-28(3,4)14-16)37-24-13-22(30)21(25(38)36(5)17(2)26(39)40-6)12-23(24)35-27(37)34-18-7-9-20(10-8-18)41-29(31,32)33/h7-10,12-13,16-17,19H,11,14-15H2,1-6H3,(H,34,35)	IKZLHRBYXXUMPD-UHFFFAOYSA-N	389352	US9951027, 2-126-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 620							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389352	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389352&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311164	404957954							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777996	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C#N	InChI=1S/C25H27F3N4O/c1-23(2)12-18(13-24(3,4)15-23)32-21-10-5-16(14-29)11-20(21)31-22(32)30-17-6-8-19(9-7-17)33-25(26,27)28/h5-11,18H,12-13,15H2,1-4H3,(H,30,31)	DMCGAJYSJGMUFP-UHFFFAOYSA-N	389353	US9951027, 2-136::1-(3,3,5,5-Tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazole-5-carbonitrile	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389353	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389353&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318531	404957955							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777997	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(SC(F)(F)F)cc2)nc2cc(Br)ccc12 |r|	InChI=1S/C23H25BrF3N3S/c1-14-10-17(13-22(2,3)12-14)30-20-9-4-15(24)11-19(20)29-21(30)28-16-5-7-18(8-6-16)31-23(25,26)27/h4-9,11,14,17H,10,12-13H2,1-3H3,(H,28,29)	ZPKIVVIKRSTXHL-UHFFFAOYSA-N	389354	US9951027, 2-137::(+-) 5-bromo-N-{4-[(trifluoromethyl)sulfanyl]phenyl}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-2-amine	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 380							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389354	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389354&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310444	404957956							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777998	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(O)=O	InChI=1S/C25H28F3N3O3/c1-23(2)12-17(13-24(3,4)14-23)31-20-10-5-15(21(32)33)11-19(20)30-22(31)29-16-6-8-18(9-7-16)34-25(26,27)28/h5-11,17H,12-14H2,1-4H3,(H,29,30)(H,32,33)	PPYKJQVCILXAQD-UHFFFAOYSA-N	389355	US9951027, 2-139::2-{[4-(trifluoromethoxy)phenyl]amino}-1-(3,3,5,5-tetramethylcyclohexyl)-1H-benzimidazole-5-carboxylic acid	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389355	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389355&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318400	404957957							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
777999	COC(=O)c1cc2nc(Nc3ccc(OC(C)C)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2cc1OC	InChI=1S/C29H39N3O4/c1-18(2)36-21-11-9-19(10-12-21)30-27-31-23-13-22(26(33)35-8)25(34-7)14-24(23)32(27)20-15-28(3,4)17-29(5,6)16-20/h9-14,18,20H,15-17H2,1-8H3,(H,30,31)	XSIXGAPZJSEGJW-UHFFFAOYSA-N	389356	US9951027, 2-140	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 60.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389356	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389356&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311076	404957958							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778000	COC(=O)c1cc2nc(Nc3ccc(cc3)C(C)C)n(C3CC(C)(C)CC(C)(C)C3)c2cc1OC	InChI=1S/C29H39N3O3/c1-18(2)19-9-11-20(12-10-19)30-27-31-23-13-22(26(33)35-8)25(34-7)14-24(23)32(27)21-15-28(3,4)17-29(5,6)16-21/h9-14,18,21H,15-17H2,1-8H3,(H,30,31)	XVQCBBYRRCXTKL-UHFFFAOYSA-N	389357	US9951027, 2-141	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389357	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389357&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311097	404957959							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778001	COc1cc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2cc1C(O)=O	InChI=1S/C28H37N3O3/c1-17(2)18-8-10-19(11-9-18)29-26-30-22-12-21(25(32)33)24(34-7)13-23(22)31(26)20-14-27(3,4)16-28(5,6)15-20/h8-13,17,20H,14-16H2,1-7H3,(H,29,30)(H,32,33)	HUPJFEWGSQNHNM-UHFFFAOYSA-N	389358	US9951027, 2-142::6-methoxy-2-{[4-(propan-2-yl)phenyl]amino}-1-(3,3,5,5-tetramethylcyclohexyl)-1H-benzimidazole-5-carboxylic acid	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 8.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389358	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389358&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318183	404957960							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778002	CC(C)Oc1ccc(Nc2nc3cc(C(O)=O)c(C)cc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C27H35N3O3/c1-16(2)33-21-9-7-19(8-10-21)28-26-29-23-13-22(25(31)32)18(4)12-24(23)30(26)20-11-17(3)14-27(5,6)15-20/h7-10,12-13,16-17,20H,11,14-15H2,1-6H3,(H,28,29)(H,31,32)	KSWHCUXDWSAARY-UHFFFAOYSA-N	389359	US9951027, 2-143	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389359	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389359&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318426	404957961							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778003	CC(C)Oc1ccc(Nc2nc3cc(C(O)=O)c(C)cc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C27H35N3O3/c1-16(2)33-21-9-7-19(8-10-21)28-26-29-23-13-22(25(31)32)18(4)12-24(23)30(26)20-11-17(3)14-27(5,6)15-20/h7-10,12-13,16-17,20H,11,14-15H2,1-6H3,(H,28,29)(H,31,32)	KSWHCUXDWSAARY-UHFFFAOYSA-N	389360	US9951027, 2-143-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389360	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389360&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318427	404957962							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778004	CC(C)Oc1ccc(Nc2nc3cc(C(O)=O)c(C)cc3n2[C@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C27H35N3O3/c1-16(2)33-21-9-7-19(8-10-21)28-26-29-23-13-22(25(31)32)18(4)12-24(23)30(26)20-11-17(3)14-27(5,6)15-20/h7-10,12-13,16-17,20H,11,14-15H2,1-6H3,(H,28,29)(H,31,32)	KSWHCUXDWSAARY-UHFFFAOYSA-N	389361	US9951027, 2-143-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389361	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389361&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011546	404957963							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778005	CC(C)c1ccc(Nc2nc3cc(C(O)=O)c(C)cc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C27H35N3O2/c1-16(2)19-7-9-20(10-8-19)28-26-29-23-13-22(25(31)32)18(4)12-24(23)30(26)21-11-17(3)14-27(5,6)15-21/h7-10,12-13,16-17,21H,11,14-15H2,1-6H3,(H,28,29)(H,31,32)	IATHDAJCYPMUDV-UHFFFAOYSA-N	389362	US9951027, 2-144-1::US9951027, 2-144	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 9.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389362	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389362&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318507	404957964							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778006	CC(C)c1ccc(Nc2nc3cc(C(O)=O)c(C)cc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C27H35N3O2/c1-16(2)19-7-9-20(10-8-19)28-26-29-23-13-22(25(31)32)18(4)12-24(23)30(26)21-11-17(3)14-27(5,6)15-21/h7-10,12-13,16-17,21H,11,14-15H2,1-6H3,(H,28,29)(H,31,32)	IATHDAJCYPMUDV-UHFFFAOYSA-N	389362	US9951027, 2-144-1::US9951027, 2-144	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389362	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389362&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318507	404957964							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778007	CC(C)c1ccc(Nc2nc3cc(C(O)=O)c(C)cc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C27H35N3O2/c1-16(2)19-7-9-20(10-8-19)28-26-29-23-13-22(25(31)32)18(4)12-24(23)30(26)21-11-17(3)14-27(5,6)15-21/h7-10,12-13,16-17,21H,11,14-15H2,1-6H3,(H,28,29)(H,31,32)	IATHDAJCYPMUDV-UHFFFAOYSA-N	389364	US9951027, 2-144-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 4.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389364	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389364&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130201955	404957965							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778008	COC(=O)c1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(C)C)cc3)nc2c1OC	InChI=1S/C29H39N3O4/c1-18(2)36-21-11-9-19(10-12-21)30-27-31-24-23(14-13-22(25(24)34-7)26(33)35-8)32(27)20-15-28(3,4)17-29(5,6)16-20/h9-14,18,20H,15-17H2,1-8H3,(H,30,31)	KEPQGFSHBABRQZ-UHFFFAOYSA-N	389365	US9951027, 2-146::US9951027, 2-145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 240							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389365	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389365&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311100	404957966							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778009	COC(=O)c1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(C)C)cc3)nc2c1OC	InChI=1S/C29H39N3O4/c1-18(2)36-21-11-9-19(10-12-21)30-27-31-24-23(14-13-22(25(24)34-7)26(33)35-8)32(27)20-15-28(3,4)17-29(5,6)16-20/h9-14,18,20H,15-17H2,1-8H3,(H,30,31)	KEPQGFSHBABRQZ-UHFFFAOYSA-N	389365	US9951027, 2-146::US9951027, 2-145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389365	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389365&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311100	404957966							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778010	COc1c(ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(C)C)cc3)nc12)C(O)=O	InChI=1S/C28H37N3O4/c1-17(2)35-20-10-8-18(9-11-20)29-26-30-23-22(13-12-21(25(32)33)24(23)34-7)31(26)19-14-27(3,4)16-28(5,6)15-19/h8-13,17,19H,14-16H2,1-7H3,(H,29,30)(H,32,33)	DLPXFXYKYBVVBE-UHFFFAOYSA-N	389367	US9951027, 2-147	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389367	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389367&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318193	404957967							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778011	COc1c(ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc12)C(O)=O	InChI=1S/C28H37N3O3/c1-17(2)18-8-10-19(11-9-18)29-26-30-23-22(13-12-21(25(32)33)24(23)34-7)31(26)20-14-27(3,4)16-28(5,6)15-20/h8-13,17,20H,14-16H2,1-7H3,(H,29,30)(H,32,33)	NLSMAONPBMEERO-UHFFFAOYSA-N	389368	US9951027, 2-148	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389368	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389368&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318192	404957968							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778012	COC(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC |r|	InChI=1S/C26H30F3N3O4/c1-15-10-17(14-25(2,3)13-15)32-21-12-22(34-4)19(23(33)35-5)11-20(21)31-24(32)30-16-6-8-18(9-7-16)36-26(27,28)29/h6-9,11-12,15,17H,10,13-14H2,1-5H3,(H,30,31)	FRJZZWRSRBDJEB-UHFFFAOYSA-N	389369	US9951027, 2-149::(+-) methyl 6-methoxy-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylate	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389369	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389369&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310990	404957969							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778013	COC(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C26H30F3N3O4/c1-15-10-17(14-25(2,3)13-15)32-21-12-22(34-4)19(23(33)35-5)11-20(21)31-24(32)30-16-6-8-18(9-7-16)36-26(27,28)29/h6-9,11-12,15,17H,10,13-14H2,1-5H3,(H,30,31)	FRJZZWRSRBDJEB-UHFFFAOYSA-N	389370	US9951027, 2-149-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 460							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389370	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389370&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310990	404957970							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778014	COC(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C26H30F3N3O4/c1-15-10-17(14-25(2,3)13-15)32-21-12-22(34-4)19(23(33)35-5)11-20(21)31-24(32)30-16-6-8-18(9-7-16)36-26(27,28)29/h6-9,11-12,15,17H,10,13-14H2,1-5H3,(H,30,31)	FRJZZWRSRBDJEB-UHFFFAOYSA-N	389371	US9951027, 2-149-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 90.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389371	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389371&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311016	404957971							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778015	COC(=O)c1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC |r|	InChI=1S/C28H37N3O4/c1-17(2)35-21-10-8-19(9-11-21)29-27-30-23-13-22(26(32)34-7)25(33-6)14-24(23)31(27)20-12-18(3)15-28(4,5)16-20/h8-11,13-14,17-18,20H,12,15-16H2,1-7H3,(H,29,30)	MTJLYSDZSGKULZ-UHFFFAOYSA-N	389372	US9951027, 2-150::(+-) methyl 6-methoxy-2-{[4-(propan-2-yloxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylate	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 120							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389372	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389372&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310288	404957972							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778016	COC(=O)c1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C28H37N3O4/c1-17(2)35-21-10-8-19(9-11-21)29-27-30-23-13-22(26(32)34-7)25(33-6)14-24(23)31(27)20-12-18(3)15-28(4,5)16-20/h8-11,13-14,17-18,20H,12,15-16H2,1-7H3,(H,29,30)	MTJLYSDZSGKULZ-UHFFFAOYSA-N	389373	US9951027, 2-150-2::US9951027, 2-150-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 950							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389373	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389373&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310288	404957973							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778017	COC(=O)c1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C28H37N3O4/c1-17(2)35-21-10-8-19(9-11-21)29-27-30-23-13-22(26(32)34-7)25(33-6)14-24(23)31(27)20-12-18(3)15-28(4,5)16-20/h8-11,13-14,17-18,20H,12,15-16H2,1-7H3,(H,29,30)	MTJLYSDZSGKULZ-UHFFFAOYSA-N	389373	US9951027, 2-150-2::US9951027, 2-150-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389373	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389373&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310288	404957973							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778018	COC(=O)c1cc2nc(Nc3ccc(cc3)C(C)C)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C28H37N3O3/c1-17(2)19-8-10-20(11-9-19)29-27-30-23-13-22(26(32)34-7)25(33-6)14-24(23)31(27)21-12-18(3)15-28(4,5)16-21/h8-11,13-14,17-18,21H,12,15-16H2,1-7H3,(H,29,30)	RTYBYVPYYMCJDN-UHFFFAOYSA-N	389375	US9951027, 2-151	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389375	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389375&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130201965	404957974							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778019	COC(=O)c1cc2nc(Nc3ccc(cc3)C(C)C)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C28H37N3O3/c1-17(2)19-8-10-20(11-9-19)29-27-30-23-13-22(26(32)34-7)25(33-6)14-24(23)31(27)21-12-18(3)15-28(4,5)16-21/h8-11,13-14,17-18,21H,12,15-16H2,1-7H3,(H,29,30)	RTYBYVPYYMCJDN-UHFFFAOYSA-N	389376	US9951027, 2-151-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 220							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389376	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389376&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311117	404957975							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778020	COC(=O)c1cc2nc(Nc3ccc(cc3)C(C)C)n([C@H]3C[C@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C28H37N3O3/c1-17(2)19-8-10-20(11-9-19)29-27-30-23-13-22(26(32)34-7)25(33-6)14-24(23)31(27)21-12-18(3)15-28(4,5)16-21/h8-11,13-14,17-18,21H,12,15-16H2,1-7H3,(H,29,30)	RTYBYVPYYMCJDN-UHFFFAOYSA-N	389377	US9951027, 2-151-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389377	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389377&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011547	404957976							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778021	COC(=O)c1cc2nc(Nc3ccc(cc3)C(F)(F)F)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C26H30F3N3O3/c1-15-10-18(14-25(2,3)13-15)32-21-12-22(34-4)19(23(33)35-5)11-20(21)31-24(32)30-17-8-6-16(7-9-17)26(27,28)29/h6-9,11-12,15,18H,10,13-14H2,1-5H3,(H,30,31)	KBQMWEUYEWSHSG-UHFFFAOYSA-N	389378	US9951027, 2-152	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389378	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389378&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318365	404957977							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778022	COC(=O)c1cc2nc(Nc3ccc(cc3)C(F)(F)F)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C26H30F3N3O3/c1-15-10-18(14-25(2,3)13-15)32-21-12-22(34-4)19(23(33)35-5)11-20(21)31-24(32)30-17-8-6-16(7-9-17)26(27,28)29/h6-9,11-12,15,18H,10,13-14H2,1-5H3,(H,30,31)	KBQMWEUYEWSHSG-UHFFFAOYSA-N	389379	US9951027, 2-152-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 730							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389379	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389379&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311054	404957978							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778023	COC(=O)c1cc2nc(Nc3ccc(cc3)C(F)(F)F)n([C@H]3C[C@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C26H30F3N3O3/c1-15-10-18(14-25(2,3)13-15)32-21-12-22(34-4)19(23(33)35-5)11-20(21)31-24(32)30-17-8-6-16(7-9-17)26(27,28)29/h6-9,11-12,15,18H,10,13-14H2,1-5H3,(H,30,31)	KBQMWEUYEWSHSG-UHFFFAOYSA-N	389380	US9951027, 2-152-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389380	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389380&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011548	404957979							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778024	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C(O)=O |r|	InChI=1S/C25H28F3N3O4/c1-14-9-16(13-24(2,3)12-14)31-20-11-21(34-4)18(22(32)33)10-19(20)30-23(31)29-15-5-7-17(8-6-15)35-25(26,27)28/h5-8,10-11,14,16H,9,12-13H2,1-4H3,(H,29,30)(H,32,33)	WFJZSFAKEGXHRN-UHFFFAOYSA-N	389381	(+-) 6-methoxy-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylic acid::US9951027, 2-153-2::US9951027, 2-153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 9.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389381	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389381&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311065	404957980							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778025	COc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C(O)=O |r|	InChI=1S/C25H28F3N3O4/c1-14-9-16(13-24(2,3)12-14)31-20-11-21(34-4)18(22(32)33)10-19(20)30-23(31)29-15-5-7-17(8-6-15)35-25(26,27)28/h5-8,10-11,14,16H,9,12-13H2,1-4H3,(H,29,30)(H,32,33)	WFJZSFAKEGXHRN-UHFFFAOYSA-N	389382	US9951027, 2-153-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389382	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389382&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311001	404957981							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778026	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C(O)=O |r|	InChI=1S/C25H28F3N3O4/c1-14-9-16(13-24(2,3)12-14)31-20-11-21(34-4)18(22(32)33)10-19(20)30-23(31)29-15-5-7-17(8-6-15)35-25(26,27)28/h5-8,10-11,14,16H,9,12-13H2,1-4H3,(H,29,30)(H,32,33)	WFJZSFAKEGXHRN-UHFFFAOYSA-N	389381	(+-) 6-methoxy-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylic acid::US9951027, 2-153-2::US9951027, 2-153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 4.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389381	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389381&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311065	404957980							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778027	COc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(C)C)cc3)nc2cc1C(O)=O |r|	InChI=1S/C27H35N3O4/c1-16(2)34-20-9-7-18(8-10-20)28-26-29-22-12-21(25(31)32)24(33-6)13-23(22)30(26)19-11-17(3)14-27(4,5)15-19/h7-10,12-13,16-17,19H,11,14-15H2,1-6H3,(H,28,29)(H,31,32)	PGHIGCKEBHXYOD-UHFFFAOYSA-N	389384	US9951027, 2-154	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389384	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389384&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318402	404957982							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778028	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)F)cc3)nc2cc1C(O)=O	InChI=1S/C25H29F2N3O4/c1-14-9-16(13-25(2,3)12-14)30-20-11-21(33-4)18(22(31)32)10-19(20)29-24(30)28-15-5-7-17(8-6-15)34-23(26)27/h5-8,10-11,14,16,23H,9,12-13H2,1-4H3,(H,28,29)(H,31,32)	LLLWKCAOCHYFHL-UHFFFAOYSA-N	389385	US9951027, 2-154-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 280							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389385	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389385&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011549	404957983							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778029	COc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)F)cc3)nc2cc1C(O)=O	InChI=1S/C25H29F2N3O4/c1-14-9-16(13-25(2,3)12-14)30-20-11-21(33-4)18(22(31)32)10-19(20)29-24(30)28-15-5-7-17(8-6-15)34-23(26)27/h5-8,10-11,14,16,23H,9,12-13H2,1-4H3,(H,28,29)(H,31,32)	LLLWKCAOCHYFHL-UHFFFAOYSA-N	389386	US9951027, 2-154-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389386	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389386&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011550	404957984							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778030	COc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2cc1C(O)=O |r|	InChI=1S/C27H35N3O3/c1-16(2)18-7-9-19(10-8-18)28-26-29-22-12-21(25(31)32)24(33-6)13-23(22)30(26)20-11-17(3)14-27(4,5)15-20/h7-10,12-13,16-17,20H,11,14-15H2,1-6H3,(H,28,29)(H,31,32)	WRKBQAWSCHNHEW-UHFFFAOYSA-N	389387	US9951027, 2-155	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 9.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389387	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389387&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130201957	404957985							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778031	COc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2cc1C(O)=O	InChI=1S/C27H35N3O3/c1-16(2)18-7-9-19(10-8-18)28-26-29-22-12-21(25(31)32)24(33-6)13-23(22)30(26)20-11-17(3)14-27(4,5)15-20/h7-10,12-13,16-17,20H,11,14-15H2,1-6H3,(H,28,29)(H,31,32)	WRKBQAWSCHNHEW-UHFFFAOYSA-N	389388	US9951027, 2-155-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389388	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389388&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130201957	404957986							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778032	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2cc1C(O)=O	InChI=1S/C27H35N3O3/c1-16(2)18-7-9-19(10-8-18)28-26-29-22-12-21(25(31)32)24(33-6)13-23(22)30(26)20-11-17(3)14-27(4,5)15-20/h7-10,12-13,16-17,20H,11,14-15H2,1-6H3,(H,28,29)(H,31,32)	WRKBQAWSCHNHEW-UHFFFAOYSA-N	389389	US9951027, 2-155-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 3.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389389	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389389&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318461	404957987							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778033	COc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(F)(F)F)nc2cc1C(O)=O |r|	InChI=1S/C25H28F3N3O3/c1-14-9-17(13-24(2,3)12-14)31-20-11-21(34-4)18(22(32)33)10-19(20)30-23(31)29-16-7-5-15(6-8-16)25(26,27)28/h5-8,10-11,14,17H,9,12-13H2,1-4H3,(H,29,30)(H,32,33)	LRPWZHSZAYKBPY-UHFFFAOYSA-N	389390	US9951027, 2-156	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389390	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389390&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318462	404957988							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778034	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)(F)F)nc2cc1C(O)=O	InChI=1S/C26H31F2N3O3/c1-15-10-18(14-25(2,3)13-15)31-21-12-22(34-5)19(23(32)33)11-20(21)30-24(31)29-17-8-6-16(7-9-17)26(4,27)28/h6-9,11-12,15,18H,10,13-14H2,1-5H3,(H,29,30)(H,32,33)	NXNRMBZYCHGADU-UHFFFAOYSA-N	389391	US9951027, 2-156-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 160							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389391&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011551	404957989							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778035	COc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(F)(F)F)nc2cc1C(O)=O	InChI=1S/C25H28F3N3O3/c1-14-9-17(13-24(2,3)12-14)31-20-11-21(34-4)18(22(32)33)10-19(20)30-23(31)29-16-7-5-15(6-8-16)25(26,27)28/h5-8,10-11,14,17H,9,12-13H2,1-4H3,(H,29,30)(H,32,33)	LRPWZHSZAYKBPY-UHFFFAOYSA-N	389392	US9951027, 2-156-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 9.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389392	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389392&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318462	404957990							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778036	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C(N)=O |r|	InChI=1S/C25H29F3N4O3/c1-14-9-16(13-24(2,3)12-14)32-20-11-21(34-4)18(22(29)33)10-19(20)31-23(32)30-15-5-7-17(8-6-15)35-25(26,27)28/h5-8,10-11,14,16H,9,12-13H2,1-4H3,(H2,29,33)(H,30,31)	LCYNTVVLTFQTGJ-UHFFFAOYSA-N	389393	US9951027, 2-157::(+-) 6-methoxy-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxamide	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389393&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311101	404957991							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778037	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(F)(F)F)nc2cc1C(N)=O	InChI=1S/C25H29F3N4O2/c1-14-9-17(13-24(2,3)12-14)32-20-11-21(34-4)18(22(29)33)10-19(20)31-23(32)30-16-7-5-15(6-8-16)25(26,27)28/h5-8,10-11,14,17H,9,12-13H2,1-4H3,(H2,29,33)(H,30,31)	RURVTLXBKQGMFZ-UHFFFAOYSA-N	389394	US9951027, 2-157-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389394	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389394&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011552	404957992							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778038	COc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(F)(F)F)nc2cc1C(N)=O	InChI=1S/C25H29F3N4O2/c1-14-9-17(13-24(2,3)12-14)32-20-11-21(34-4)18(22(29)33)10-19(20)31-23(32)30-16-7-5-15(6-8-16)25(26,27)28/h5-8,10-11,14,17H,9,12-13H2,1-4H3,(H2,29,33)(H,30,31)	RURVTLXBKQGMFZ-UHFFFAOYSA-N	389395	US9951027, 2-157-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389395	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389395&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011553	404957993							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778039	CCOc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C25H30F3N3O2/c1-5-32-20-10-11-22-21(13-20)30-23(31(22)18-12-16(2)14-24(3,4)15-18)29-17-6-8-19(9-7-17)33-25(26,27)28/h6-11,13,16,18H,5,12,14-15H2,1-4H3,(H,29,30)	UAIPUTUZXRDUSD-UHFFFAOYSA-N	389396	US9951027, 3-32	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389396	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389396&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011554	404957994							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778040	CCOc1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C25H30F3N3O2/c1-5-32-20-10-11-22-21(13-20)30-23(31(22)18-12-16(2)14-24(3,4)15-18)29-17-6-8-19(9-7-17)33-25(26,27)28/h6-11,13,16,18H,5,12,14-15H2,1-4H3,(H,29,30)	UAIPUTUZXRDUSD-UHFFFAOYSA-N	389397	US9951027, 3-36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389397	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389397&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011555	404957995							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778041	COc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)F)cc3)nc2c1	InChI=1S/C24H29F2N3O2/c1-15-11-17(14-24(2,3)13-15)29-21-10-9-19(30-4)12-20(21)28-23(29)27-16-5-7-18(8-6-16)31-22(25)26/h5-10,12,15,17,22H,11,13-14H2,1-4H3,(H,27,28)	PSFFCISMKCOFCE-UHFFFAOYSA-N	389398	US9951027, 3-40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 100.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389398	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389398&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011556	404957996							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778042	COc1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(C)C)cc3)nc2c1	InChI=1S/C26H35N3O2/c1-17(2)31-21-9-7-19(8-10-21)27-25-28-23-14-22(30-6)11-12-24(23)29(25)20-13-18(3)15-26(4,5)16-20/h7-12,14,17-18,20H,13,15-16H2,1-6H3,(H,27,28)	PLLQUDRHXURKAX-UHFFFAOYSA-N	389399	US9951027, 3-42	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389399	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389399&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011557	404957997							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778043	COc1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C26H35N3O/c1-17(2)19-7-9-20(10-8-19)27-25-28-23-14-22(30-6)11-12-24(23)29(25)21-13-18(3)15-26(4,5)16-21/h7-12,14,17-18,21H,13,15-16H2,1-6H3,(H,27,28)	AFIRUZAZZLLYDK-UHFFFAOYSA-N	389400	US9951027, 3-43	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389400	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389400&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011558	404957998							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778044	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(C)cc2)nc2ccccc12 |r|	InChI=1S/C23H29N3/c1-16-9-11-18(12-10-16)24-22-25-20-7-5-6-8-21(20)26(22)19-13-17(2)14-23(3,4)15-19/h5-12,17,19H,13-15H2,1-4H3,(H,24,25)	HVZNIHAWXWIFDY-UHFFFAOYSA-N	389401	US9951027, 3-44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 360							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389401	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389401&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311028	404957999							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778045	COC(=O)c1ccc(Nc2nc3ccccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C24H29N3O2/c1-16-13-19(15-24(2,3)14-16)27-21-8-6-5-7-20(21)26-23(27)25-18-11-9-17(10-12-18)22(28)29-4/h5-12,16,19H,13-15H2,1-4H3,(H,25,26)	UMFWSYPVLJNXAV-UHFFFAOYSA-N	389402	US9951027, 3-45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 860							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389402	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389402&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311021	404958000							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778046	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(O)=O)nc2ccccc12 |r|	InChI=1S/C23H27N3O2/c1-15-12-18(14-23(2,3)13-15)26-20-7-5-4-6-19(20)25-22(26)24-17-10-8-16(9-11-17)21(27)28/h4-11,15,18H,12-14H2,1-3H3,(H,24,25)(H,27,28)	AMYVYGAOBGMVOX-UHFFFAOYSA-N	389403	US9951027, 3-46	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389403	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389403&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311015	404958001							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778047	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)[N+]([O-])=O)nc2ccccc12 |r|	InChI=1S/C22H26N4O2/c1-15-12-18(14-22(2,3)13-15)25-20-7-5-4-6-19(20)24-21(25)23-16-8-10-17(11-9-16)26(27)28/h4-11,15,18H,12-14H2,1-3H3,(H,23,24)	YZSGNIDRCCRLMF-UHFFFAOYSA-N	389404	US9951027, 3-47	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389404	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389404&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311130	404958002							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778048	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(N)cc2)nc2ccccc12 |r|	InChI=1S/C22H28N4/c1-15-12-18(14-22(2,3)13-15)26-20-7-5-4-6-19(20)25-21(26)24-17-10-8-16(23)9-11-17/h4-11,15,18H,12-14,23H2,1-3H3,(H,24,25)	AKCNCVKCXVRQLA-UHFFFAOYSA-N	389405	US9951027, 3-48	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2800							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389405	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389405&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318406	404958003							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778049	C[C@@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)[N+]([O-])=O)nc2ccccc12 |r|	InChI=1S/C22H26N4O2/c1-15-12-18(14-22(2,3)13-15)25-20-7-5-4-6-19(20)24-21(25)23-16-8-10-17(11-9-16)26(27)28/h4-11,15,18H,12-14H2,1-3H3,(H,23,24)	YZSGNIDRCCRLMF-UHFFFAOYSA-N	389406	US9951027, 3-49	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 4200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389406	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389406&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311091	404958004							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778050	COc1ccc(Nc2nc3ccccc3n2[C@@H]2C[C@@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C23H29N3O/c1-16-13-18(15-23(2,3)14-16)26-21-8-6-5-7-20(21)25-22(26)24-17-9-11-19(27-4)12-10-17/h5-12,16,18H,13-15H2,1-4H3,(H,24,25)	VPRAHFOUHKAHTD-UHFFFAOYSA-N	389407	US9951027, 3-50	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2600							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389407	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389407&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311170	404958005							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778051	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(NC(=O)C(F)(F)F)cc2)nc2ccccc12 |r|	InChI=1S/C24H27F3N4O/c1-15-12-18(14-23(2,3)13-15)31-20-7-5-4-6-19(20)30-22(31)29-17-10-8-16(9-11-17)28-21(32)24(25,26)27/h4-11,15,18H,12-14H2,1-3H3,(H,28,32)(H,29,30)	VTVFVSOLBWOLNJ-UHFFFAOYSA-N	389408	US9951027, 3-51	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 930							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389408	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389408&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311114	404958006							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778052	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(NC(C)=O)cc2)nc2ccccc12 |r|	InChI=1S/C24H30N4O/c1-16-13-20(15-24(3,4)14-16)28-22-8-6-5-7-21(22)27-23(28)26-19-11-9-18(10-12-19)25-17(2)29/h5-12,16,20H,13-15H2,1-4H3,(H,25,29)(H,26,27)	WFEOZTQXSQQMKK-UHFFFAOYSA-N	389409	US9951027, 3-52	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 9400							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389409	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389409&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318540	404958007							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778053	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(NC(=O)C3CCS(=O)(=O)CC3)cc2)nc2ccccc12 |r|	InChI=1S/C28H36N4O3S/c1-19-16-23(18-28(2,3)17-19)32-25-7-5-4-6-24(25)31-27(32)30-22-10-8-21(9-11-22)29-26(33)20-12-14-36(34,35)15-13-20/h4-11,19-20,23H,12-18H2,1-3H3,(H,29,33)(H,30,31)	NJYWJOKNDFTGBB-UHFFFAOYSA-N	389410	US9951027, 3-53	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389410	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389410&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318583	404958008							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778054	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(=O)Nc1ccc(F)cc1 |r|	InChI=1S/C30H30F4N4O2/c1-18-14-23(17-29(2,3)16-18)38-26-13-4-19(27(39)35-21-7-5-20(31)6-8-21)15-25(26)37-28(38)36-22-9-11-24(12-10-22)40-30(32,33)34/h4-13,15,18,23H,14,16-17H2,1-3H3,(H,35,39)(H,36,37)	ZCVMBFVYLNZLDD-UHFFFAOYSA-N	389411	US9951027, 3-54	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2100							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389411	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389411&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311140	404958009							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778055	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(=O)NCCN(C)C |r|	InChI=1S/C28H36F3N5O2/c1-18-14-21(17-27(2,3)16-18)36-24-11-6-19(25(37)32-12-13-35(4)5)15-23(24)34-26(36)33-20-7-9-22(10-8-20)38-28(29,30)31/h6-11,15,18,21H,12-14,16-17H2,1-5H3,(H,32,37)(H,33,34)	VNGLULQQFHELBG-UHFFFAOYSA-N	389412	US9951027, 3-55	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 600							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389412	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389412&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311217	404958010							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778056	CCc1ccc(Nc2nc3cc(ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)C(=O)Nc2ccc(F)cc2)cc1 |r|	InChI=1S/C31H35FN4O/c1-5-21-6-11-25(12-7-21)34-30-35-27-17-22(29(37)33-24-13-9-23(32)10-14-24)8-15-28(27)36(30)26-16-20(2)18-31(3,4)19-26/h6-15,17,20,26H,5,16,18-19H2,1-4H3,(H,33,37)(H,34,35)	LCDHPFLJCDTOPU-UHFFFAOYSA-N	389413	US9951027, 3-56	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 6100							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389413	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389413&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318379	404958011							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778057	C[C@@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(NC(=O)C3(O)CC3)cc2)nc2ccccc12 |r|	InChI=1S/C26H32N4O2/c1-17-14-20(16-25(2,3)15-17)30-22-7-5-4-6-21(22)29-24(30)28-19-10-8-18(9-11-19)27-23(31)26(32)12-13-26/h4-11,17,20,32H,12-16H2,1-3H3,(H,27,31)(H,28,29)	LZSDHZZZWGZGPW-UHFFFAOYSA-N	389414	US9951027, 3-57	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389414	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389414&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311207	404958012							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778058	CCc1ccc(Nc2nc3cc(ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)C(=O)NCc2ccc(F)cc2)cc1 |r|	InChI=1S/C32H37FN4O/c1-5-22-8-13-26(14-9-22)35-31-36-28-17-24(30(38)34-20-23-6-11-25(33)12-7-23)10-15-29(28)37(31)27-16-21(2)18-32(3,4)19-27/h6-15,17,21,27H,5,16,18-20H2,1-4H3,(H,34,38)(H,35,36)	XVQPIOBOAXRBOV-UHFFFAOYSA-N	389415	US9951027, 3-58	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389415	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389415&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318382	404958013							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778059	CCc1ccc(Nc2nc3cc(ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)C(=O)NC2CCCC2)cc1 |r|	InChI=1S/C30H40N4O/c1-5-21-10-13-24(14-11-21)32-29-33-26-17-22(28(35)31-23-8-6-7-9-23)12-15-27(26)34(29)25-16-20(2)18-30(3,4)19-25/h10-15,17,20,23,25H,5-9,16,18-19H2,1-4H3,(H,31,35)(H,32,33)	OIJVFHSEJHUBGC-UHFFFAOYSA-N	389416	US9951027, 3-59	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 810							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389416	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389416&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318255	404958014							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778060	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(=O)NC1CCS(=O)(=O)CC1 |r|	InChI=1S/C29H35F3N4O4S/c1-18-14-22(17-28(2,3)16-18)36-25-9-4-19(26(37)33-21-10-12-41(38,39)13-11-21)15-24(25)35-27(36)34-20-5-7-23(8-6-20)40-29(30,31)32/h4-9,15,18,21-22H,10-14,16-17H2,1-3H3,(H,33,37)(H,34,35)	JOGWYLSKCHFZSC-UHFFFAOYSA-N	389417	US9951027, 3-60	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389417	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389417&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318254	404958015							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778061	COc1ccc(Nc2nc3c(F)cccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C23H28FN3O/c1-15-12-17(14-23(2,3)13-15)27-20-7-5-6-19(24)21(20)26-22(27)25-16-8-10-18(28-4)11-9-16/h5-11,15,17H,12-14H2,1-4H3,(H,25,26)	ZSXVZPYETAGXFP-UHFFFAOYSA-N	389418	US9951027, 3-61	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1100							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389418	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389418&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311243	404958016							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778062	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(=O)NC1CC1 |r|	InChI=1S/C27H31F3N4O2/c1-16-12-20(15-26(2,3)14-16)34-23-11-4-17(24(35)31-18-5-6-18)13-22(23)33-25(34)32-19-7-9-21(10-8-19)36-27(28,29)30/h4,7-11,13,16,18,20H,5-6,12,14-15H2,1-3H3,(H,31,35)(H,32,33)	LHRRUPLRAORZFG-UHFFFAOYSA-N	389419	US9951027, 3-62	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 340							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389419	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389419&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311181	404958017							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778063	CCOc1ccc(Nc2nc3cc(ccc3n2[C@@H]2C[C@@H](C)CC(C)(C)C2)C(=O)OC)cc1 |r|	InChI=1S/C26H33N3O3/c1-6-32-21-10-8-19(9-11-21)27-25-28-22-14-18(24(30)31-5)7-12-23(22)29(25)20-13-17(2)15-26(3,4)16-20/h7-12,14,17,20H,6,13,15-16H2,1-5H3,(H,27,28)	FPVAEYCTSKJBBM-UHFFFAOYSA-N	389420	US9951027, 3-63	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 3400							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389420	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389420&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318587	404958018							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778064	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(F)cc2)nc2cc(ccc12)C(O)=O |r|	InChI=1S/C23H26FN3O2/c1-14-10-18(13-23(2,3)12-14)27-20-9-4-15(21(28)29)11-19(20)26-22(27)25-17-7-5-16(24)6-8-17/h4-9,11,14,18H,10,12-13H2,1-3H3,(H,25,26)(H,28,29)	LDZOLIBYZLTSOK-UHFFFAOYSA-N	389421	US9951027, 3-64	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2100							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389421	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389421&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311002	404958019							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778065	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C#N)nc2cc(ccc12)C(O)=O |r|	InChI=1S/C24H26N4O2/c1-15-10-19(13-24(2,3)12-15)28-21-9-6-17(22(29)30)11-20(21)27-23(28)26-18-7-4-16(14-25)5-8-18/h4-9,11,15,19H,10,12-13H2,1-3H3,(H,26,27)(H,29,30)	XKUZDGXAHAETPA-UHFFFAOYSA-N	389422	US9951027, 3-65	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1600							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389422	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389422&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310976	404958020							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778066	CCOc1ccc(Nc2nc3cc(ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)C(O)=O)cc1 |r|	InChI=1S/C25H31N3O3/c1-5-31-20-9-7-18(8-10-20)26-24-27-21-13-17(23(29)30)6-11-22(21)28(24)19-12-16(2)14-25(3,4)15-19/h6-11,13,16,19H,5,12,14-15H2,1-4H3,(H,26,27)(H,29,30)	MKNBKCVZWYOYAC-UHFFFAOYSA-N	389423	US9951027, 3-66	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 500							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389423	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389423&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311042	404958021							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778067	CCOc1ccc(Nc2nc3cc(ccc3n2[C@@H]2C[C@@H](C)CC(C)(C)C2)C(O)=O)cc1 |r|	InChI=1S/C25H31N3O3/c1-5-31-20-9-7-18(8-10-20)26-24-27-21-13-17(23(29)30)6-11-22(21)28(24)19-12-16(2)14-25(3,4)15-19/h6-11,13,16,19H,5,12,14-15H2,1-4H3,(H,26,27)(H,29,30)	MKNBKCVZWYOYAC-UHFFFAOYSA-N	389424	US9951027, 3-67	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389424	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389424&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310986	404958022							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778068	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(NS(=O)(=O)c3ccccc3F)ccc12 |r|	InChI=1S/C29H30F4N4O3S/c1-18-14-21(17-28(2,3)16-18)37-25-13-10-20(36-41(38,39)26-7-5-4-6-23(26)30)15-24(25)35-27(37)34-19-8-11-22(12-9-19)40-29(31,32)33/h4-13,15,18,21,36H,14,16-17H2,1-3H3,(H,34,35)	ZMABKXMAAYIYFV-UHFFFAOYSA-N	389425	US9951027, 3-68	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 370							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389425	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389425&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311242	404958023							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778069	C[C@@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C#N |r|	InChI=1S/C24H25F3N4O/c1-15-10-18(13-23(2,3)12-15)31-21-9-4-16(14-28)11-20(21)30-22(31)29-17-5-7-19(8-6-17)32-24(25,26)27/h4-9,11,15,18H,10,12-13H2,1-3H3,(H,29,30)	OUFZYTLVORPLOR-UHFFFAOYSA-N	389426	US9951027, 3-69	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389426	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389426&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318589	404958024							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778070	C[C@@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)S(C)(=O)=O |r|	InChI=1S/C24H28F3N3O3S/c1-15-11-17(14-23(2,3)13-15)30-21-10-9-19(34(4,31)32)12-20(21)29-22(30)28-16-5-7-18(8-6-16)33-24(25,26)27/h5-10,12,15,17H,11,13-14H2,1-4H3,(H,28,29)	ZEUZZFMMRMXIOL-UHFFFAOYSA-N	389427	US9951027, 3-70	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 390							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389427	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389427&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311138	404958025							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778071	COC(=O)CNC(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(F)cc3)nc2c1 |r|	InChI=1S/C26H31FN4O3/c1-16-11-20(14-26(2,3)13-16)31-22-10-5-17(24(33)28-15-23(32)34-4)12-21(22)30-25(31)29-19-8-6-18(27)7-9-19/h5-10,12,16,20H,11,13-15H2,1-4H3,(H,28,33)(H,29,30)	LKYGZOVLVHQNAY-UHFFFAOYSA-N	389428	US9951027, 3-71	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389428	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389428&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318410	404958026							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778072	COC(=O)CNC(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C#N)nc2c1 |r|	InChI=1S/C27H31N5O3/c1-17-11-21(14-27(2,3)13-17)32-23-10-7-19(25(34)29-16-24(33)35-4)12-22(23)31-26(32)30-20-8-5-18(15-28)6-9-20/h5-10,12,17,21H,11,13-14,16H2,1-4H3,(H,29,34)(H,30,31)	VFRKNQIHZSQHAM-UHFFFAOYSA-N	389429	US9951027, 3-72	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389429	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389429&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318268	404958027							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778073	COC(=O)CCNC(=O)c1ccc2n(C3CC(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C28H33F3N4O4/c1-17-13-20(16-27(2,3)15-17)35-23-10-5-18(25(37)32-12-11-24(36)38-4)14-22(23)34-26(35)33-19-6-8-21(9-7-19)39-28(29,30)31/h5-10,14,17,20H,11-13,15-16H2,1-4H3,(H,32,37)(H,33,34)	IRHDHFZDBPHSRH-UHFFFAOYSA-N	389430	US9951027, 3-73-2::US9951027, 3-73-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1400							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389430	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389430&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318266	404958028							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778074	COC(=O)CCNC(=O)c1ccc2n(C3CC(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C28H33F3N4O4/c1-17-13-20(16-27(2,3)15-17)35-23-10-5-18(25(37)32-12-11-24(36)38-4)14-22(23)34-26(35)33-19-6-8-21(9-7-19)39-28(29,30)31/h5-10,14,17,20H,11-13,15-16H2,1-4H3,(H,32,37)(H,33,34)	IRHDHFZDBPHSRH-UHFFFAOYSA-N	389430	US9951027, 3-73-2::US9951027, 3-73-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 620							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389430	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389430&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318266	404958028							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778075	COC(=O)[C@@H](C)NC(=O)c1ccc2n(C3CC(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1 |r|	InChI=1S/C28H33F3N4O4/c1-16-12-20(15-27(3,4)14-16)35-23-11-6-18(24(36)32-17(2)25(37)38-5)13-22(23)34-26(35)33-19-7-9-21(10-8-19)39-28(29,30)31/h6-11,13,16-17,20H,12,14-15H2,1-5H3,(H,32,36)(H,33,34)	LXRYWGYQMGGEII-UHFFFAOYSA-N	389432	US9951027, 3-74-2::US9951027, 3-74-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389432	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389432&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318591	404958029							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778076	COC(=O)[C@@H](C)NC(=O)c1ccc2n(C3CC(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1 |r|	InChI=1S/C28H33F3N4O4/c1-16-12-20(15-27(3,4)14-16)35-23-11-6-18(24(36)32-17(2)25(37)38-5)13-22(23)34-26(35)33-19-7-9-21(10-8-19)39-28(29,30)31/h6-11,13,16-17,20H,12,14-15H2,1-5H3,(H,32,36)(H,33,34)	LXRYWGYQMGGEII-UHFFFAOYSA-N	389432	US9951027, 3-74-2::US9951027, 3-74-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1100							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389432	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389432&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318591	404958029							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778077	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(F)cc2)nc2cc(ccc12)C(=O)NCC(O)=O |r|	InChI=1S/C25H29FN4O3/c1-15-10-19(13-25(2,3)12-15)30-21-9-4-16(23(33)27-14-22(31)32)11-20(21)29-24(30)28-18-7-5-17(26)6-8-18/h4-9,11,15,19H,10,12-14H2,1-3H3,(H,27,33)(H,28,29)(H,31,32)	SNUCKBYCIIYKRE-UHFFFAOYSA-N	389434	US9951027, 3-75	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 9700							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389434	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389434&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311152	404958030							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778078	CC(C)Oc1ccc(Nc2nc3cc(Br)ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C25H32BrN3O/c1-16(2)30-21-9-7-19(8-10-21)27-24-28-22-13-18(26)6-11-23(22)29(24)20-12-17(3)14-25(4,5)15-20/h6-11,13,16-17,20H,12,14-15H2,1-5H3,(H,27,28)	VZUJKYMXVXXWLP-UHFFFAOYSA-N	389435	US9951027, 3-76	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1500							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389435	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389435&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318384	404958031							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778079	CC(C)c1ccc(Nc2nc3cc(Br)ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C25H32BrN3/c1-16(2)18-6-9-20(10-7-18)27-24-28-22-13-19(26)8-11-23(22)29(24)21-12-17(3)14-25(4,5)15-21/h6-11,13,16-17,21H,12,14-15H2,1-5H3,(H,27,28)	WTIAUMVIOTWYMF-UHFFFAOYSA-N	389436	US9951027, 3-77	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 400							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389436	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389436&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318412	404958032							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778080	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C#N)nc2cc(ccc12)C(=O)NCC(O)=O |r|	InChI=1S/C26H29N5O3/c1-16-10-20(13-26(2,3)12-16)31-22-9-6-18(24(34)28-15-23(32)33)11-21(22)30-25(31)29-19-7-4-17(14-27)5-8-19/h4-9,11,16,20H,10,12-13,15H2,1-3H3,(H,28,34)(H,29,30)(H,32,33)	IZLPJNHUHXHSOG-UHFFFAOYSA-N	389437	US9951027, 3-78	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 3400							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389437	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389437&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311155	404958033							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778081	CCc1ccc(Nc2nc3cc(ccc3n2C2CC(C)CC(C)(C)C2)C(=O)NCCO)cc1	InChI=1S/C27H36N4O2/c1-5-19-6-9-21(10-7-19)29-26-30-23-15-20(25(33)28-12-13-32)8-11-24(23)31(26)22-14-18(2)16-27(3,4)17-22/h6-11,15,18,22,32H,5,12-14,16-17H2,1-4H3,(H,28,33)(H,29,30)	GUYZDDPQIYXTKN-UHFFFAOYSA-N	389438	US9951027, 3-79-2::US9951027, 3-79-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389438	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389438&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318414	404958034					C04080		1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778082	CCc1ccc(Nc2nc3cc(ccc3n2C2CC(C)CC(C)(C)C2)C(=O)NCCO)cc1	InChI=1S/C27H36N4O2/c1-5-19-6-9-21(10-7-19)29-26-30-23-15-20(25(33)28-12-13-32)8-11-24(23)31(26)22-14-18(2)16-27(3,4)17-22/h6-11,15,18,22,32H,5,12-14,16-17H2,1-4H3,(H,28,33)(H,29,30)	GUYZDDPQIYXTKN-UHFFFAOYSA-N	389438	US9951027, 3-79-2::US9951027, 3-79-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389438	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389438&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318414	404958034					C04080		1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778083	C[C@@H]1CCC[C@@H](C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccccc12 |r|	InChI=1S/C21H22F3N3O/c1-14-5-4-6-16(13-14)27-19-8-3-2-7-18(19)26-20(27)25-15-9-11-17(12-10-15)28-21(22,23)24/h2-3,7-12,14,16H,4-6,13H2,1H3,(H,25,26)	ZVKGDXDEAZQDHY-UHFFFAOYSA-N	389440	US9951027, 3-80	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 310							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389440	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389440&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311083	404958035							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778084	CC(C)Oc1ccc(Nc2nc3ccccc3n2[C@H]2CCC[C@@H](C)C2)cc1 |r|	InChI=1S/C23H29N3O/c1-16(2)27-20-13-11-18(12-14-20)24-23-25-21-9-4-5-10-22(21)26(23)19-8-6-7-17(3)15-19/h4-5,9-14,16-17,19H,6-8,15H2,1-3H3,(H,24,25)	UUECNAKSHFUENG-UHFFFAOYSA-N	389441	US9951027, 3-81	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389441	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389441&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318542	404958036							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778085	C[C@H]1CCC[C@@H](C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccccc12 |r|	InChI=1S/C21H22F3N3O/c1-14-5-4-6-16(13-14)27-19-8-3-2-7-18(19)26-20(27)25-15-9-11-17(12-10-15)28-21(22,23)24/h2-3,7-12,14,16H,4-6,13H2,1H3,(H,25,26)	ZVKGDXDEAZQDHY-UHFFFAOYSA-N	389442	US9951027, 3-82	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1500							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389442	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389442&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311165	404958037							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778086	CC(C)Oc1ccc(Nc2nc3ccccc3n2[C@H]2CCC[C@H](C)C2)cc1 |r|	InChI=1S/C23H29N3O/c1-16(2)27-20-13-11-18(12-14-20)24-23-25-21-9-4-5-10-22(21)26(23)19-8-6-7-17(3)15-19/h4-5,9-14,16-17,19H,6-8,15H2,1-3H3,(H,24,25)	UUECNAKSHFUENG-UHFFFAOYSA-N	389443	US9951027, 3-83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389443&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311254	404958038							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778087	CC(C)Oc1ccc(Nc2nc3ccccc3n2[C@@H]2CCCC(C)(C)C2)cc1 |r|	InChI=1S/C24H31N3O/c1-17(2)28-20-13-11-18(12-14-20)25-23-26-21-9-5-6-10-22(21)27(23)19-8-7-15-24(3,4)16-19/h5-6,9-14,17,19H,7-8,15-16H2,1-4H3,(H,25,26)	UALAMOYGLNXDJR-UHFFFAOYSA-N	389444	US9951027, 3-84	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 450							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389444	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389444&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311216	404958039							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778088	COC(=O)CN(C)C(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1F |r|	InChI=1S/C28H32F4N4O4/c1-16-10-18(14-27(2,3)13-16)36-23-12-21(29)20(25(38)35(4)15-24(37)39-5)11-22(23)34-26(36)33-17-6-8-19(9-7-17)40-28(30,31)32/h6-9,11-12,16,18H,10,13-15H2,1-5H3,(H,33,34)	UWKRKGTVZKUXLV-UHFFFAOYSA-N	389445	US9951027, 3-85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 380							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389445&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311106	404958040							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778089	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(=O)NS(C)(=O)=O)c(F)cc12 |r|	InChI=1S/C25H28F4N4O4S/c1-14-9-16(13-24(2,3)12-14)33-21-11-19(26)18(22(34)32-38(4,35)36)10-20(21)31-23(33)30-15-5-7-17(8-6-15)37-25(27,28)29/h5-8,10-11,14,16H,9,12-13H2,1-4H3,(H,30,31)(H,32,34)	QKFJCQPEBACAAA-UHFFFAOYSA-N	389446	US9951027, 3-86	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 660							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389446	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389446&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318593	404958041							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778090	CNS(=O)(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1 |r|	InChI=1S/C24H29F3N4O3S/c1-15-11-17(14-23(2,3)13-15)31-21-10-9-19(35(32,33)28-4)12-20(21)30-22(31)29-16-5-7-18(8-6-16)34-24(25,26)27/h5-10,12,15,17,28H,11,13-14H2,1-4H3,(H,29,30)	GUMQZWKZQYNJTB-UHFFFAOYSA-N	389447	US9951027, 3-87	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 330							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389447	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389447&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130201963	404958042							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778091	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)S(=O)Cc1ccccc1	InChI=1S/C30H32F3N3O2S/c1-20-15-23(18-29(2,3)17-20)36-27-14-13-25(39(37)19-21-7-5-4-6-8-21)16-26(27)35-28(36)34-22-9-11-24(12-10-22)38-30(31,32)33/h4-14,16,20,23H,15,17-19H2,1-3H3,(H,34,35)	MPMCJXNJLUHYLL-UHFFFAOYSA-N	389448	US9951027, 3-88	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 700							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389448	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389448&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318261	404958043							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778092	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(=O)NCc1ncccc1C(F)(F)F	InChI=1S/C31H31F6N5O2/c1-18-13-21(16-29(2,3)15-18)42-26-11-6-19(27(43)39-17-25-23(30(32,33)34)5-4-12-38-25)14-24(26)41-28(42)40-20-7-9-22(10-8-20)44-31(35,36)37/h4-12,14,18,21H,13,15-17H2,1-3H3,(H,39,43)(H,40,41)	HSUNNSUTRFYUKD-UHFFFAOYSA-N	389449	US9951027, 3-89-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389449	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389449&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318267	404958044							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778093	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(=O)NCc1ncc(cc1Cl)C(F)(F)F	InChI=1S/C31H30ClF6N5O2/c1-17-10-21(14-29(2,3)13-17)43-26-9-4-18(27(44)40-16-25-23(32)12-19(15-39-25)30(33,34)35)11-24(26)42-28(43)41-20-5-7-22(8-6-20)45-31(36,37)38/h4-9,11-12,15,17,21H,10,13-14,16H2,1-3H3,(H,40,44)(H,41,42)	RFRYWQFDSZVKAY-UHFFFAOYSA-N	389450	US9951027, 3-90-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 8000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389450	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389450&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318389	404958045							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778094	COC(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1C |r|	InChI=1S/C26H30F3N3O3/c1-15-12-18(14-25(3,4)13-15)32-21-11-10-20(23(33)34-5)16(2)22(21)31-24(32)30-17-6-8-19(9-7-17)35-26(27,28)29/h6-11,15,18H,12-14H2,1-5H3,(H,30,31)	AAJGWYAOOGDVKW-UHFFFAOYSA-N	389451	US9951027, 3-91	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 680							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389451	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389451&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311017	404958046							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778095	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(N)ccc12	InChI=1S/C23H27F3N4O/c1-14-10-17(13-22(2,3)12-14)30-20-9-4-15(27)11-19(20)29-21(30)28-16-5-7-18(8-6-16)31-23(24,25)26/h4-9,11,14,17H,10,12-13,27H2,1-3H3,(H,28,29)	RDPQSHZPMPAIGN-UHFFFAOYSA-N	389452	US9951027, 3-92-2::US9951027, 3-92-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 150							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389452	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389452&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318258	404958047							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778096	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(N)ccc12	InChI=1S/C23H27F3N4O/c1-14-10-17(13-22(2,3)12-14)30-20-9-4-15(27)11-19(20)29-21(30)28-16-5-7-18(8-6-16)31-23(24,25)26/h4-9,11,14,17H,10,12-13,27H2,1-3H3,(H,28,29)	RDPQSHZPMPAIGN-UHFFFAOYSA-N	389452	US9951027, 3-92-2::US9951027, 3-92-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389452	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389452&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318258	404958047							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778097	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(N)=O)c(C)cc12 |r|	InChI=1S/C25H29F3N4O2/c1-14-9-17(13-24(3,4)12-14)32-21-10-15(2)19(22(29)33)11-20(21)31-23(32)30-16-5-7-18(8-6-16)34-25(26,27)28/h5-8,10-11,14,17H,9,12-13H2,1-4H3,(H2,29,33)(H,30,31)	ALHIXJMFKYQIRK-UHFFFAOYSA-N	389454	US9951027, 3-93	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389454	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389454&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318544	404958048							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778098	COc1c(ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc12)C(N)=O	InChI=1S/C26H31F3N4O3/c1-24(2)12-16(13-25(3,4)14-24)33-19-11-10-18(22(30)34)21(35-5)20(19)32-23(33)31-15-6-8-17(9-7-15)36-26(27,28)29/h6-11,16H,12-14H2,1-5H3,(H2,30,34)(H,31,32)	ZAHXQAQSACQUMK-UHFFFAOYSA-N	389455	US9951027, 3-94	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389455	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389455&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318546	404958049							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778099	CC(C)Oc1ccc(Nc2nc3c(F)c(ccc3n2C2CC(C)(C)CC(C)(C)C2)C(N)=O)cc1	InChI=1S/C27H35FN4O2/c1-16(2)34-19-9-7-17(8-10-19)30-25-31-23-21(12-11-20(22(23)28)24(29)33)32(25)18-13-26(3,4)15-27(5,6)14-18/h7-12,16,18H,13-15H2,1-6H3,(H2,29,33)(H,30,31)	JGNFSQNQDVPBFT-UHFFFAOYSA-N	389456	US9951027, 3-95	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 100.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389456	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389456&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318417	404958050							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778100	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2c(C)c(ccc12)C(O)=O |r|	InChI=1S/C25H28F3N3O3/c1-14-11-17(13-24(3,4)12-14)31-20-10-9-19(22(32)33)15(2)21(20)30-23(31)29-16-5-7-18(8-6-16)34-25(26,27)28/h5-10,14,17H,11-13H2,1-4H3,(H,29,30)(H,32,33)	UZOSCNKBPBEHBO-UHFFFAOYSA-N	389457	US9951027, 3-96	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389457	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389457&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318418	404958051							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778101	CC(C)Oc1ccc(Nc2nc3c(C)c(ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)C(O)=O)cc1 |r|	InChI=1S/C27H35N3O3/c1-16(2)33-21-9-7-19(8-10-21)28-26-29-24-18(4)22(25(31)32)11-12-23(24)30(26)20-13-17(3)14-27(5,6)15-20/h7-12,16-17,20H,13-15H2,1-6H3,(H,28,29)(H,31,32)	JMPPSUZBOWTPDM-UHFFFAOYSA-N	389458	US9951027, 3-97	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 310							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389458	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389458&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318466	404958052							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778102	CC(C)c1ccc(Nc2nc3c(C)c(ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)C(O)=O)cc1 |r|	InChI=1S/C27H35N3O2/c1-16(2)19-7-9-20(10-8-19)28-26-29-24-18(4)22(25(31)32)11-12-23(24)30(26)21-13-17(3)14-27(5,6)15-21/h7-12,16-17,21H,13-15H2,1-6H3,(H,28,29)(H,31,32)	LWLVUUCWXXPHHJ-UHFFFAOYSA-N	389459	US9951027, 3-98	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389459	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389459&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318468	404958053							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778103	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(NC(C)=O)ccc12	InChI=1S/C25H29F3N4O2/c1-15-11-19(14-24(3,4)13-15)32-22-10-7-18(29-16(2)33)12-21(22)31-23(32)30-17-5-8-20(9-6-17)34-25(26,27)28/h5-10,12,15,19H,11,13-14H2,1-4H3,(H,29,33)(H,30,31)	NCTHJIKZHSNYKN-UHFFFAOYSA-N	389460	US9951027, 3-99-2::US9951027, 3-99-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 450							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389460	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389460&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318469	404958054							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778104	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(NC(C)=O)ccc12	InChI=1S/C25H29F3N4O2/c1-15-11-19(14-24(3,4)13-15)32-22-10-7-18(29-16(2)33)12-21(22)31-23(32)30-17-5-8-20(9-6-17)34-25(26,27)28/h5-10,12,15,19H,11,13-14H2,1-4H3,(H,29,33)(H,30,31)	NCTHJIKZHSNYKN-UHFFFAOYSA-N	389460	US9951027, 3-99-2::US9951027, 3-99-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 140							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389460	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389460&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318469	404958054							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778105	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(NC(=O)C3CC3)ccc12	InChI=1S/C27H31F3N4O2/c1-16-12-20(15-26(2,3)14-16)34-23-11-8-19(31-24(35)17-4-5-17)13-22(23)33-25(34)32-18-6-9-21(10-7-18)36-27(28,29)30/h6-11,13,16-17,20H,4-5,12,14-15H2,1-3H3,(H,31,35)(H,32,33)	LTLHOIXXQXZLPC-UHFFFAOYSA-N	389462	US9951027, 3-100-2::US9951027, 3-100-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389462	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389462&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318385	404958055							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778106	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(NC(=O)C3CC3)ccc12	InChI=1S/C27H31F3N4O2/c1-16-12-20(15-26(2,3)14-16)34-23-11-8-19(31-24(35)17-4-5-17)13-22(23)33-25(34)32-18-6-9-21(10-7-18)36-27(28,29)30/h6-11,13,16-17,20H,4-5,12,14-15H2,1-3H3,(H,31,35)(H,32,33)	LTLHOIXXQXZLPC-UHFFFAOYSA-N	389462	US9951027, 3-100-2::US9951027, 3-100-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 190							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389462	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389462&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318385	404958055							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778107	COCC(=O)Nc1ccc2n(C3CC(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C26H31F3N4O3/c1-16-11-19(14-25(2,3)13-16)33-22-10-7-18(30-23(34)15-35-4)12-21(22)32-24(33)31-17-5-8-20(9-6-17)36-26(27,28)29/h5-10,12,16,19H,11,13-15H2,1-4H3,(H,30,34)(H,31,32)	DYGDZIZUHKEKCE-UHFFFAOYSA-N	389464	US9951027, 3-101-2::US9951027, 3-101-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 350							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389464	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389464&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318555	404958056							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778108	COCC(=O)Nc1ccc2n(C3CC(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C26H31F3N4O3/c1-16-11-19(14-25(2,3)13-16)33-22-10-7-18(30-23(34)15-35-4)12-21(22)32-24(33)31-17-5-8-20(9-6-17)36-26(27,28)29/h5-10,12,16,19H,11,13-15H2,1-4H3,(H,30,34)(H,31,32)	DYGDZIZUHKEKCE-UHFFFAOYSA-N	389464	US9951027, 3-101-2::US9951027, 3-101-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 140							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389464	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389464&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318555	404958056							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778109	COC(=O)Nc1ccc2n(C3CC(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C25H29F3N4O3/c1-15-11-18(14-24(2,3)13-15)32-21-10-7-17(30-23(33)34-4)12-20(21)31-22(32)29-16-5-8-19(9-6-16)35-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,29,31)(H,30,33)	MZXWBRPJMOEUOJ-UHFFFAOYSA-N	389466	US9951027, 3-102-2::US9951027, 3-102-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 810							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389466	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389466&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318263	404958057							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778110	COC(=O)Nc1ccc2n(C3CC(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C25H29F3N4O3/c1-15-11-18(14-24(2,3)13-15)32-21-10-7-17(30-23(33)34-4)12-20(21)31-22(32)29-16-5-8-19(9-6-16)35-25(26,27)28/h5-10,12,15,18H,11,13-14H2,1-4H3,(H,29,31)(H,30,33)	MZXWBRPJMOEUOJ-UHFFFAOYSA-N	389466	US9951027, 3-102-2::US9951027, 3-102-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 130							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389466	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389466&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318263	404958057							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778111	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(NC(=O)CO)ccc12	InChI=1S/C25H29F3N4O3/c1-15-10-18(13-24(2,3)12-15)32-21-9-6-17(29-22(34)14-33)11-20(21)31-23(32)30-16-4-7-19(8-5-16)35-25(26,27)28/h4-9,11,15,18,33H,10,12-14H2,1-3H3,(H,29,34)(H,30,31)	HSULUCXGVMPEQU-UHFFFAOYSA-N	389468	US9951027, 3-103-2::US9951027, 3-103-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 470							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389468	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389468&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318259	404958058							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778112	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(NC(=O)CO)ccc12	InChI=1S/C25H29F3N4O3/c1-15-10-18(13-24(2,3)12-15)32-21-9-6-17(29-22(34)14-33)11-20(21)31-23(32)30-16-4-7-19(8-5-16)35-25(26,27)28/h4-9,11,15,18,33H,10,12-14H2,1-3H3,(H,29,34)(H,30,31)	HSULUCXGVMPEQU-UHFFFAOYSA-N	389468	US9951027, 3-103-2::US9951027, 3-103-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 90.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389468	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389468&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318259	404958058							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778113	COc1c(ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc12)C(N)=O	InChI=1S/C28H38N4O2/c1-17(2)18-8-10-19(11-9-18)30-26-31-23-22(13-12-21(25(29)33)24(23)34-7)32(26)20-14-27(3,4)16-28(5,6)15-20/h8-13,17,20H,14-16H2,1-7H3,(H2,29,33)(H,30,31)	UENYYKADOCLCMF-UHFFFAOYSA-N	389470	US9951027, 3-104	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 110							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389470&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318264	404958059							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778114	CC(C)c1ccc(Nc2nc3c(C)c(ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)C(N)=O)cc1 |r|	InChI=1S/C27H36N4O/c1-16(2)19-7-9-20(10-8-19)29-26-30-24-18(4)22(25(28)32)11-12-23(24)31(26)21-13-17(3)14-27(5,6)15-21/h7-12,16-17,21H,13-15H2,1-6H3,(H2,28,32)(H,29,30)	JWIQEDUFVXAJDZ-UHFFFAOYSA-N	389471	US9951027, 3-105	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 120							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389471	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389471&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318260	404958060							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778115	CCN(CC)C(=O)c1ccc2n(C3CC(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1C	InChI=1S/C29H37F3N4O2/c1-7-35(8-2)26(37)23-13-14-24-25(19(23)4)34-27(36(24)21-15-18(3)16-28(5,6)17-21)33-20-9-11-22(12-10-20)38-29(30,31)32/h9-14,18,21H,7-8,15-17H2,1-6H3,(H,33,34)	JLXSTYJKTWZTLX-UHFFFAOYSA-N	389472	US9951027, 3-106-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 700							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389472	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389472&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318556	404958061							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778116	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)S(N)(=O)=O	InChI=1S/C23H27F3N4O3S/c1-14-10-16(13-22(2,3)12-14)30-20-9-8-18(34(27,31)32)11-19(20)29-21(30)28-15-4-6-17(7-5-15)33-23(24,25)26/h4-9,11,14,16H,10,12-13H2,1-3H3,(H,28,29)(H2,27,31,32)	XITNROHALSAZKH-UHFFFAOYSA-N	389473	US9951027, 3-107-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389473&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318557	404958062							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778117	CCOc1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2c1	InChI=1S/C26H32F3N3O2/c1-6-33-20-11-12-21-22(13-20)32(18-14-24(2,3)16-25(4,5)15-18)23(31-21)30-17-7-9-19(10-8-17)34-26(27,28)29/h7-13,18H,6,14-16H2,1-5H3,(H,30,31)	IUJYEWBPWFCGRE-UHFFFAOYSA-N	389474	US9951027, 3-108	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389474	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389474&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318271	404958063							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778118	CCOc1ccc2nc(Nc3ccc(OC(C)C)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2c1	InChI=1S/C28H39N3O2/c1-8-32-23-13-14-24-25(15-23)31(21-16-27(4,5)18-28(6,7)17-21)26(30-24)29-20-9-11-22(12-10-20)33-19(2)3/h9-15,19,21H,8,16-18H2,1-7H3,(H,29,30)	ISVFRESIQKWUNA-UHFFFAOYSA-N	389475	US9951027, 3-109	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 180							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389475&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318269	404958064							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778119	CCOc1ccc2nc(Nc3ccc(cc3)C(C)C)n(C3CC(C)(C)CC(C)(C)C3)c2c1	InChI=1S/C28H39N3O/c1-8-32-23-13-14-24-25(15-23)31(22-16-27(4,5)18-28(6,7)17-22)26(30-24)29-21-11-9-20(10-12-21)19(2)3/h9-15,19,22H,8,16-18H2,1-7H3,(H,29,30)	VFRVNMIQOUWJFY-UHFFFAOYSA-N	389476	US9951027, 3-110	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389476	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389476&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318270	404958065							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778120	COC(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1F |r|	InChI=1S/C25H27F4N3O3/c1-14-11-16(13-24(2,3)12-14)32-19-10-9-18(22(33)34-4)20(26)21(19)31-23(32)30-15-5-7-17(8-6-15)35-25(27,28)29/h5-10,14,16H,11-13H2,1-4H3,(H,30,31)	JXPKARZEHPMMCC-UHFFFAOYSA-N	389477	US9951027, 3-111	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 500							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389477	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389477&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311004	404958066							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778121	CCOc1ccc2nc(Nc3ccc(OC(C)C)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C27H37N3O2/c1-7-31-23-12-13-24-25(15-23)30(21-14-19(4)16-27(5,6)17-21)26(29-24)28-20-8-10-22(11-9-20)32-18(2)3/h8-13,15,18-19,21H,7,14,16-17H2,1-6H3,(H,28,29)	BGMXGPVQEATJOP-UHFFFAOYSA-N	389478	US9951027, 3-112	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 170							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389478&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318272	404958067							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778122	COC(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1OCC(F)(F)F |r|	InChI=1S/C27H29F6N3O4/c1-15-9-17(13-25(2,3)12-15)36-21-11-22(39-14-26(28,29)30)19(23(37)38-4)10-20(21)35-24(36)34-16-5-7-18(8-6-16)40-27(31,32)33/h5-8,10-11,15,17H,9,12-14H2,1-4H3,(H,34,35)	MTSNWHXEHAHKFM-UHFFFAOYSA-N	389479	US9951027, 3-113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 6000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389479	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389479&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130201933	404958068							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778123	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(O)=O)c(OCC(F)(F)F)cc12 |r|	InChI=1S/C26H27F6N3O4/c1-14-8-16(12-24(2,3)11-14)35-20-10-21(38-13-25(27,28)29)18(22(36)37)9-19(20)34-23(35)33-15-4-6-17(7-5-15)39-26(30,31)32/h4-7,9-10,14,16H,8,11-13H2,1-3H3,(H,33,34)(H,36,37)	YTDGSWQEPRTUPB-UHFFFAOYSA-N	389480	US9951027, 3-114	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 280							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389480	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389480&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311027	404958069							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778124	Cc1cc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C#N	InChI=1S/C26H29F3N4O/c1-16-10-22-21(11-17(16)14-30)32-23(31-18-6-8-20(9-7-18)34-26(27,28)29)33(22)19-12-24(2,3)15-25(4,5)13-19/h6-11,19H,12-13,15H2,1-5H3,(H,31,32)	NGGNKMCOUVCJFC-UHFFFAOYSA-N	389481	US9951027, 3-115	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389481&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318567	404958070							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778125	Cc1cc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C(=O)NS(C)(=O)=O	InChI=1S/C27H33F3N4O4S/c1-16-11-22-21(12-20(16)23(35)33-39(6,36)37)32-24(31-17-7-9-19(10-8-17)38-27(28,29)30)34(22)18-13-25(2,3)15-26(4,5)14-18/h7-12,18H,13-15H2,1-6H3,(H,31,32)(H,33,35)	JPOFKEGPDJRZRF-UHFFFAOYSA-N	389482	US9951027, 3-116	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389482	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389482&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311255	404958071							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778126	Cc1cc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C(=O)NS(=O)(=O)C1CC1	InChI=1S/C29H35F3N4O4S/c1-17-12-24-23(13-22(17)25(37)35-41(38,39)21-10-11-21)34-26(33-18-6-8-20(9-7-18)40-29(30,31)32)36(24)19-14-27(2,3)16-28(4,5)15-19/h6-9,12-13,19,21H,10-11,14-16H2,1-5H3,(H,33,34)(H,35,37)	NHOQUCMFLRFSIL-UHFFFAOYSA-N	389483	US9951027, 3-117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 60.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389483&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311111	404958072							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778127	COc1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2c1	InChI=1S/C25H30F3N3O2/c1-23(2)13-17(14-24(3,4)15-23)31-21-12-19(32-5)10-11-20(21)30-22(31)29-16-6-8-18(9-7-16)33-25(26,27)28/h6-12,17H,13-15H2,1-5H3,(H,29,30)	MWYMNBZHNUZSHV-UHFFFAOYSA-N	389484	US9951027, 3-118	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389484&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318568	404958073							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778128	COc1ccc2nc(Nc3ccc(OC(C)C)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2c1	InChI=1S/C27H37N3O2/c1-18(2)32-21-10-8-19(9-11-21)28-25-29-23-13-12-22(31-7)14-24(23)30(25)20-15-26(3,4)17-27(5,6)16-20/h8-14,18,20H,15-17H2,1-7H3,(H,28,29)	XIEJVFQFHRCKHF-UHFFFAOYSA-N	389485	US9951027, 3-119	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 60.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389485&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318392	404958074							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778129	COc1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2c1 |r|	InChI=1S/C24H28F3N3O2/c1-15-11-17(14-23(2,3)13-15)30-21-12-19(31-4)9-10-20(21)29-22(30)28-16-5-7-18(8-6-16)32-24(25,26)27/h5-10,12,15,17H,11,13-14H2,1-4H3,(H,28,29)	WUQLHGWSMYMDIS-UHFFFAOYSA-N	389486	US9951027, 3-120	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 50.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389486	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389486&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318393	404958075							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778130	COC(=O)c1cc2nc(Nc3ccc(cc3)C(F)(F)F)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1C |r|	InChI=1S/C26H30F3N3O2/c1-15-10-19(14-25(3,4)13-15)32-22-11-16(2)20(23(33)34-5)12-21(22)31-24(32)30-18-8-6-17(7-9-18)26(27,28)29/h6-9,11-12,15,19H,10,13-14H2,1-5H3,(H,30,31)	RHDUUZGCENKCTI-UHFFFAOYSA-N	389487	US9951027, 3-121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 110							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389487&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311031	404958076							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778131	CC(C)Oc1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2c1	InChI=1S/C27H34F3N3O2/c1-17(2)34-21-11-12-22-23(13-21)33(19-14-25(3,4)16-26(5,6)15-19)24(32-22)31-18-7-9-20(10-8-18)35-27(28,29)30/h7-13,17,19H,14-16H2,1-6H3,(H,31,32)	XZLQTZKNZJWRSN-UHFFFAOYSA-N	389488	US9951027, 3-122	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 130							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389488&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318390	404958077							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778132	CC(C)Oc1ccc(Nc2nc3ccc(OC(C)C)cc3n2C2CC(C)(C)CC(C)(C)C2)cc1	InChI=1S/C29H41N3O2/c1-19(2)33-23-11-9-21(10-12-23)30-27-31-25-14-13-24(34-20(3)4)15-26(25)32(27)22-16-28(5,6)18-29(7,8)17-22/h9-15,19-20,22H,16-18H2,1-8H3,(H,30,31)	YDKQWEWJPNHUEQ-UHFFFAOYSA-N	389489	US9951027, 3-123	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 530							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389489&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318597	404958078							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778133	CC(C)c1ccc(Nc2nc3c(F)c(ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)C(O)=O)cc1 |r|	InChI=1S/C26H32FN3O2/c1-15(2)17-6-8-18(9-7-17)28-25-29-23-21(11-10-20(22(23)27)24(31)32)30(25)19-12-16(3)13-26(4,5)14-19/h6-11,15-16,19H,12-14H2,1-5H3,(H,28,29)(H,31,32)	JXUIDNGFNAWSHM-UHFFFAOYSA-N	389490	US9951027, 3-124	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389490&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318599	404958079							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778134	COCc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C(=O)OC |r|	InChI=1S/C27H32F3N3O4/c1-16-10-19(14-26(2,3)13-16)33-23-11-17(15-35-4)21(24(34)36-5)12-22(23)32-25(33)31-18-6-8-20(9-7-18)37-27(28,29)30/h6-9,11-12,16,19H,10,13-15H2,1-5H3,(H,31,32)	IZPKYVMWQAJFDI-UHFFFAOYSA-N	389491	US9951027, 3-125	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 170							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389491	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389491&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311056	404958080							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778135	COCc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(C)C)cc3)nc2cc1C(=O)OC |r|	InChI=1S/C29H39N3O4/c1-18(2)36-23-10-8-21(9-11-23)30-28-31-25-14-24(27(33)35-7)20(17-34-6)13-26(25)32(28)22-12-19(3)15-29(4,5)16-22/h8-11,13-14,18-19,22H,12,15-17H2,1-7H3,(H,30,31)	FTTOWZWYSGPDLT-UHFFFAOYSA-N	389492	US9951027, 3-126	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 300							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389492&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311071	404958081							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778136	COCc1cc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2cc1C(=O)OC	InChI=1S/C30H41N3O3/c1-19(2)20-9-11-22(12-10-20)31-28-32-25-14-24(27(34)36-8)21(17-35-7)13-26(25)33(28)23-15-29(3,4)18-30(5,6)16-23/h9-14,19,23H,15-18H2,1-8H3,(H,31,32)	OTTFMMZTGCZGTC-UHFFFAOYSA-N	389493	US9951027, 3-127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389493&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310999	404958082							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778137	Cc1ccc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2c1	InChI=1S/C25H30F3N3O/c1-16-6-11-20-21(12-16)31(18-13-23(2,3)15-24(4,5)14-18)22(30-20)29-17-7-9-19(10-8-17)32-25(26,27)28/h6-12,18H,13-15H2,1-5H3,(H,29,30)	HSXFYYQCAJWLSI-UHFFFAOYSA-N	389494	US9951027, 3-128	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389494	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389494&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318423	404958083							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778138	COc1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1 |r|	InChI=1S/C24H28F3N3O2/c1-15-11-17(14-23(2,3)13-15)30-21-10-9-19(31-4)12-20(21)29-22(30)28-16-5-7-18(8-6-16)32-24(25,26)27/h5-10,12,15,17H,11,13-14H2,1-4H3,(H,28,29)	UVWROFPDGORUFT-UHFFFAOYSA-N	389495	US9951027, 3-129	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 120							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389495&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318429	404958084							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778139	COc1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C27H37N3O/c1-18(2)19-8-10-20(11-9-19)28-25-29-23-14-22(31-7)12-13-24(23)30(25)21-15-26(3,4)17-27(5,6)16-21/h8-14,18,21H,15-17H2,1-7H3,(H,28,29)	ZUIAFNCUMPDYHA-UHFFFAOYSA-N	389496	US9951027, 3-130	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389496	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389496&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311205	404958085							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778140	COC(=O)c1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@@H]3CCCC(C)(C)C3)c2cc1C |r|	InChI=1S/C27H35N3O3/c1-17(2)33-21-11-9-19(10-12-21)28-26-29-23-15-22(25(31)32-6)18(3)14-24(23)30(26)20-8-7-13-27(4,5)16-20/h9-12,14-15,17,20H,7-8,13,16H2,1-6H3,(H,28,29)	YPTAOZPWQLCEHS-UHFFFAOYSA-N	389497	US9951027, 3-131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389497	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389497&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318473	404958086							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778141	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C#N |r|	InChI=1S/C24H25F3N4O/c1-15-10-18(13-23(2,3)12-15)31-21-9-4-16(14-28)11-20(21)30-22(31)29-17-5-7-19(8-6-17)32-24(25,26)27/h4-9,11,15,18H,10,12-13H2,1-3H3,(H,29,30)	OUFZYTLVORPLOR-UHFFFAOYSA-N	389498	US9951027, 3-132	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 400							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389498	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389498&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310996	404958087							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778142	CC(C)Oc1ccc(Nc2nc3cc(ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)C#N)cc1 |r|	InChI=1S/C26H32N4O/c1-17(2)31-22-9-7-20(8-10-22)28-25-29-23-13-19(16-27)6-11-24(23)30(25)21-12-18(3)14-26(4,5)15-21/h6-11,13,17-18,21H,12,14-15H2,1-5H3,(H,28,29)	PPBPGZBLUFPNCU-UHFFFAOYSA-N	389499	US9951027, 3-133	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 600							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389499	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389499&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318569	404958088							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778143	CC(C)c1ccc(Nc2nc3cc(ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)C#N)cc1 |r|	InChI=1S/C26H32N4/c1-17(2)20-7-9-21(10-8-20)28-25-29-23-13-19(16-27)6-11-24(23)30(25)22-12-18(3)14-26(4,5)15-22/h6-11,13,17-18,22H,12,14-15H2,1-5H3,(H,28,29)	ZVCCJDSGFMZHQD-UHFFFAOYSA-N	389500	US9951027, 3-134	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 230							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389500	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389500&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311025	404958089							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778144	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(ccc12)C#N |r|	InChI=1S/C24H25F3N4/c1-15-10-19(13-23(2,3)12-15)31-21-9-4-16(14-28)11-20(21)30-22(31)29-18-7-5-17(6-8-18)24(25,26)27/h4-9,11,15,19H,10,12-13H2,1-3H3,(H,29,30)	DXEMNYXYVUHRQW-UHFFFAOYSA-N	389501	US9951027, 3-135	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389501&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318430	404958090							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778145	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2ccc(OCC(F)(F)F)cc12	InChI=1S/C26H29F6N3O/c1-23(2)12-18(13-24(3,4)14-23)35-21-11-19(36-15-25(27,28)29)9-10-20(21)34-22(35)33-17-7-5-16(6-8-17)26(30,31)32/h5-11,18H,12-15H2,1-4H3,(H,33,34)	MYKKZCKIXNYPRW-UHFFFAOYSA-N	389502	US9951027, 3-136	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 3200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389502	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389502&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318570	404958091							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778146	COCc1cc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2cc1C(O)=O	InChI=1S/C29H39N3O3/c1-18(2)19-8-10-21(11-9-19)30-27-31-24-13-23(26(33)34)20(16-35-7)12-25(24)32(27)22-14-28(3,4)17-29(5,6)15-22/h8-13,18,22H,14-17H2,1-7H3,(H,30,31)(H,33,34)	XAVYRLWMHBRJOA-UHFFFAOYSA-N	389503	US9951027, 3-137	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389503&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318572	404958092							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778147	Cc1cc2n([C@@H]3CCCC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C(O)=O |r|	InChI=1S/C24H26F3N3O3/c1-14-11-20-19(12-18(14)21(31)32)29-22(30(20)16-5-4-10-23(2,3)13-16)28-15-6-8-17(9-7-15)33-24(25,26)27/h6-9,11-12,16H,4-5,10,13H2,1-3H3,(H,28,29)(H,31,32)	JONZGTDAOILKNE-UHFFFAOYSA-N	389504	US9951027, 3-138	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389504&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318479	404958093							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778148	CC(C)Oc1ccc(Nc2nc3cc(C(O)=O)c(C)cc3n2[C@@H]2CCCC(C)(C)C2)cc1 |r|	InChI=1S/C26H33N3O3/c1-16(2)32-20-10-8-18(9-11-20)27-25-28-22-14-21(24(30)31)17(3)13-23(22)29(25)19-7-6-12-26(4,5)15-19/h8-11,13-14,16,19H,6-7,12,15H2,1-5H3,(H,27,28)(H,30,31)	NITGKAJQZSUZNQ-UHFFFAOYSA-N	389505	US9951027, 3-139	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389505	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389505&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318475	404958094							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778149	CC(C)c1ccc(Nc2nc3cc(C(O)=O)c(C)cc3n2[C@@H]2CCCC(C)(C)C2)cc1 |r|	InChI=1S/C26H33N3O2/c1-16(2)18-8-10-19(11-9-18)27-25-28-22-14-21(24(30)31)17(3)13-23(22)29(25)20-7-6-12-26(4,5)15-20/h8-11,13-14,16,20H,6-7,12,15H2,1-5H3,(H,27,28)(H,30,31)	OLHNTPMHCBIKOT-UHFFFAOYSA-N	389506	US9951027, 3-140	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389506	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389506&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318478	404958095							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778150	CC(C)Oc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C(O)=O |r|	InChI=1S/C27H32F3N3O4/c1-15(2)36-23-12-22-21(11-20(23)24(34)35)32-25(33(22)18-10-16(3)13-26(4,5)14-18)31-17-6-8-19(9-7-17)37-27(28,29)30/h6-9,11-12,15-16,18H,10,13-14H2,1-5H3,(H,31,32)(H,34,35)	MAJXEFOHNUTWDC-UHFFFAOYSA-N	389507	US9951027, 3-141	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 60.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389507	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389507&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311005	404958096							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778151	CC(C)Oc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(F)(F)F)nc2cc1C(O)=O |r|	InChI=1S/C27H32F3N3O3/c1-15(2)36-23-12-22-21(11-20(23)24(34)35)32-25(31-18-8-6-17(7-9-18)27(28,29)30)33(22)19-10-16(3)13-26(4,5)14-19/h6-9,11-12,15-16,19H,10,13-14H2,1-5H3,(H,31,32)(H,34,35)	DVBWMBAPMRHVLT-UHFFFAOYSA-N	389508	US9951027, 3-142	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 430							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389508	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389508&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311089	404958097							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778152	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2c(C)cc(C)cc12 |r|	InChI=1S/C25H30F3N3O/c1-15-10-17(3)22-21(12-15)31(19-11-16(2)13-24(4,5)14-19)23(30-22)29-18-6-8-20(9-7-18)32-25(26,27)28/h6-10,12,16,19H,11,13-14H2,1-5H3,(H,29,30)	RDCQUGXEUWPSGP-UHFFFAOYSA-N	389509	US9951027, 3-143	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 140							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389509&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318600	404958098							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778153	CC(C)Oc1ccc(Nc2nc3c(C)cc(C)cc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C27H37N3O/c1-17(2)31-23-10-8-21(9-11-23)28-26-29-25-20(5)12-18(3)14-24(25)30(26)22-13-19(4)15-27(6,7)16-22/h8-12,14,17,19,22H,13,15-16H2,1-7H3,(H,28,29)	BABDQEQTDSRSPQ-UHFFFAOYSA-N	389510	US9951027, 3-144	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 120							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389510&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318482	404958099							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778154	CC(C)c1ccc(Nc2nc3c(C)cc(C)cc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C27H37N3/c1-17(2)21-8-10-22(11-9-21)28-26-29-25-20(5)12-18(3)14-24(25)30(26)23-13-19(4)15-27(6,7)16-23/h8-12,14,17,19,23H,13,15-16H2,1-7H3,(H,28,29)	GZZPECMXVKEISM-UHFFFAOYSA-N	389511	US9951027, 3-145	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 120							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389511	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389511&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318481	404958100							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778155	Cc1cc(C)c2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2c1	InChI=1S/C26H32F3N3O/c1-16-11-17(2)22-21(12-16)32(19-13-24(3,4)15-25(5,6)14-19)23(31-22)30-18-7-9-20(10-8-18)33-26(27,28)29/h7-12,19H,13-15H2,1-6H3,(H,30,31)	RUESZBJSAZRYCP-UHFFFAOYSA-N	389512	US9951027, 3-146	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389512&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318485	404958101							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778156	CC(C)Oc1ccc(Nc2nc3c(C)cc(C)cc3n2C2CC(C)(C)CC(C)(C)C2)cc1	InChI=1S/C28H39N3O/c1-18(2)32-23-11-9-21(10-12-23)29-26-30-25-20(4)13-19(3)14-24(25)31(26)22-15-27(5,6)17-28(7,8)16-22/h9-14,18,22H,15-17H2,1-8H3,(H,29,30)	SGMVRTZQHPCNAJ-UHFFFAOYSA-N	389513	US9951027, 3-147	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 100.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389513&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318486	404958102							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778157	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(OC(F)(F)F)cc12 |r|	InChI=1S/C24H25F6N3O2/c1-14-10-16(13-22(2,3)12-14)33-20-11-18(35-24(28,29)30)8-9-19(20)32-21(33)31-15-4-6-17(7-5-15)34-23(25,26)27/h4-9,11,14,16H,10,12-13H2,1-3H3,(H,31,32)	UQHPTNWAMPQZPK-UHFFFAOYSA-N	389514	US9951027, 3-148	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389514&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311183	404958103							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778158	CC(C)Oc1ccc(Nc2nc3ccc(OC(F)(F)F)cc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C26H32F3N3O2/c1-16(2)33-20-8-6-18(7-9-20)30-24-31-22-11-10-21(34-26(27,28)29)13-23(22)32(24)19-12-17(3)14-25(4,5)15-19/h6-11,13,16-17,19H,12,14-15H2,1-5H3,(H,30,31)	FICMQMIGCDFFAU-UHFFFAOYSA-N	389515	US9951027, 3-149	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 6500							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389515&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318606	404958104							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778159	CC(C)c1ccc(Nc2nc3ccc(OC(F)(F)F)cc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C26H32F3N3O/c1-16(2)18-6-8-19(9-7-18)30-24-31-22-11-10-21(33-26(27,28)29)13-23(22)32(24)20-12-17(3)14-25(4,5)15-20/h6-11,13,16-17,20H,12,14-15H2,1-5H3,(H,30,31)	MSHOORVQIOYBNP-UHFFFAOYSA-N	389516	US9951027, 3-150	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 3200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389516&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318432	404958105							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778160	CC(C)c1ccc(Nc2nc3ccc(OC(F)(F)F)cc3n2C2CC(C)(C)CC(C)(C)C2)cc1	InChI=1S/C27H34F3N3O/c1-17(2)18-7-9-19(10-8-18)31-24-32-22-12-11-21(34-27(28,29)30)13-23(22)33(24)20-14-25(3,4)16-26(5,6)15-20/h7-13,17,20H,14-16H2,1-6H3,(H,31,32)	CFNXCDYNULVJGQ-UHFFFAOYSA-N	389517	US9951027, 3-151	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389517&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318437	404958106							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778161	COC(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)(C)C)nc2c1 |r|	InChI=1S/C28H37N3O2/c1-18-14-22(17-28(5,6)16-18)31-24-13-8-19(25(32)33-7)15-23(24)30-26(31)29-21-11-9-20(10-12-21)27(2,3)4/h8-13,15,18,22H,14,16-17H2,1-7H3,(H,29,30)	SMEVPTYDIWFZOX-UHFFFAOYSA-N	389518	US9951027, 3-152	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389518&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318439	404958107							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778162	COC(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3cc(OC)c(OC)c(OC)c3)nc2c1 |r|	InChI=1S/C27H35N3O5/c1-16-10-19(15-27(2,3)14-16)30-21-9-8-17(25(31)35-7)11-20(21)29-26(30)28-18-12-22(32-4)24(34-6)23(13-18)33-5/h8-9,11-13,16,19H,10,14-15H2,1-7H3,(H,28,29)	NVPTXHVAPFHALN-UHFFFAOYSA-N	389519	US9951027, 3-153	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 6500							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389519&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318607	404958108							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778163	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OC(F)(F)F)ccc12	InChI=1S/C25H27F6N3O2/c1-22(2)12-16(13-23(3,4)14-22)34-20-10-9-18(36-25(29,30)31)11-19(20)33-21(34)32-15-5-7-17(8-6-15)35-24(26,27)28/h5-11,16H,12-14H2,1-4H3,(H,32,33)	HYIGERFYPJAVMA-UHFFFAOYSA-N	389520	US9951027, 3-154	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 500							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389520&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318609	404958109							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778164	CC(C)Oc1ccc(Nc2nc3cc(OC(F)(F)F)ccc3n2C2CC(C)(C)CC(C)(C)C2)cc1	InChI=1S/C27H34F3N3O2/c1-17(2)34-20-9-7-18(8-10-20)31-24-32-22-13-21(35-27(28,29)30)11-12-23(22)33(24)19-14-25(3,4)16-26(5,6)15-19/h7-13,17,19H,14-16H2,1-6H3,(H,31,32)	DLWFPULERZDYPX-UHFFFAOYSA-N	389521	US9951027, 3-155	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 290							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389521&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318574	404958110							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778165	CC(C)c1ccc(Nc2nc3cc(OC(F)(F)F)ccc3n2C2CC(C)(C)CC(C)(C)C2)cc1	InChI=1S/C27H34F3N3O/c1-17(2)18-7-9-19(10-8-18)31-24-32-22-13-21(34-27(28,29)30)11-12-23(22)33(24)20-14-25(3,4)16-26(5,6)15-20/h7-13,17,20H,14-16H2,1-6H3,(H,31,32)	MJBQGZOWYDCPSB-UHFFFAOYSA-N	389522	US9951027, 3-156	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 500							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389522&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318575	404958111							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778166	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OC(F)(F)F)ccc12 |r|	InChI=1S/C24H25F6N3O2/c1-14-10-16(13-22(2,3)12-14)33-20-9-8-18(35-24(28,29)30)11-19(20)32-21(33)31-15-4-6-17(7-5-15)34-23(25,26)27/h4-9,11,14,16H,10,12-13H2,1-3H3,(H,31,32)	WUAQRRLVNOOFFM-UHFFFAOYSA-N	389523	US9951027, 3-157	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389523	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389523&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311118	404958112							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778167	CC(C)Oc1ccc(Nc2nc3cc(OC(F)(F)F)ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C26H32F3N3O2/c1-16(2)33-20-8-6-18(7-9-20)30-24-31-22-13-21(34-26(27,28)29)10-11-23(22)32(24)19-12-17(3)14-25(4,5)15-19/h6-11,13,16-17,19H,12,14-15H2,1-5H3,(H,30,31)	NIAPFPYLKOMWHP-UHFFFAOYSA-N	389524	US9951027, 3-158	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 3200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389524	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389524&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318442	404958113							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778168	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(=O)N(C)C1CCOC1	InChI=1S/C29H35F3N4O3/c1-18-13-22(16-28(2,3)15-18)36-25-10-5-19(26(37)35(4)21-11-12-38-17-21)14-24(25)34-27(36)33-20-6-8-23(9-7-20)39-29(30,31)32/h5-10,14,18,21-22H,11-13,15-17H2,1-4H3,(H,33,34)	LITPPTKDUQSJQD-UHFFFAOYSA-N	389525	US9951027, 3-159	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 300							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389525&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318577	404958114							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778169	CC(C)(C)c1ccc(Nc2nc3cc(ccc3n2C2CC(C)(C)CC(C)(C)C2)C(O)=O)cc1	InChI=1S/C28H37N3O2/c1-26(2,3)19-9-11-20(12-10-19)29-25-30-22-14-18(24(32)33)8-13-23(22)31(25)21-15-27(4,5)17-28(6,7)16-21/h8-14,21H,15-17H2,1-7H3,(H,29,30)(H,32,33)	FPHOMCYGVQAWGQ-UHFFFAOYSA-N	389526	US9951027, 3-160	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389526&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311072	404958115							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778170	COc1cc(Nc2nc3cc(ccc3n2C2CC(C)(C)CC(C)(C)C2)C(O)=O)cc(OC)c1OC	InChI=1S/C27H35N3O5/c1-26(2)13-18(14-27(3,4)15-26)30-20-9-8-16(24(31)32)10-19(20)29-25(30)28-17-11-21(33-5)23(35-7)22(12-17)34-6/h8-12,18H,13-15H2,1-7H3,(H,28,29)(H,31,32)	UGQDWBIZQLVBCN-UHFFFAOYSA-N	389527	US9951027, 3-161	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5700							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389527&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318576	404958116							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778171	COc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1Br |r|	InChI=1S/C24H27BrF3N3O2/c1-14-9-16(13-23(2,3)12-14)31-20-11-21(32-4)18(25)10-19(20)30-22(31)29-15-5-7-17(8-6-15)33-24(26,27)28/h5-8,10-11,14,16H,9,12-13H2,1-4H3,(H,29,30)	FDBCSOPGUVYPHA-UHFFFAOYSA-N	389528	US9951027, 3-162	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 310							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389528&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311147	404958117							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778172	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(OC3CCC3)cc12	InChI=1S/C28H34F3N3O2/c1-26(2)15-19(16-27(3,4)17-26)34-24-14-22(35-20-6-5-7-20)12-13-23(24)33-25(34)32-18-8-10-21(11-9-18)36-28(29,30)31/h8-14,19-20H,5-7,15-17H2,1-4H3,(H,32,33)	KZTRSPYYKWNEAW-UHFFFAOYSA-N	389529	US9951027, 3-163	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 850							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389529&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318440	404958118							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778173	CC(C)Oc1ccc(Nc2nc3ccc(OC4CCC4)cc3n2C2CC(C)(C)CC(C)(C)C2)cc1	InChI=1S/C30H41N3O2/c1-20(2)34-24-12-10-21(11-13-24)31-28-32-26-15-14-25(35-23-8-7-9-23)16-27(26)33(28)22-17-29(3,4)19-30(5,6)18-22/h10-16,20,22-23H,7-9,17-19H2,1-6H3,(H,31,32)	GBPGPIZYCZEPOM-UHFFFAOYSA-N	389530	US9951027, 3-164	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 9000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389530&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318445	404958119							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778174	CC(C)c1ccc(Nc2nc3ccc(OC4CCC4)cc3n2C2CC(C)(C)CC(C)(C)C2)cc1	InChI=1S/C30H41N3O/c1-20(2)21-10-12-22(13-11-21)31-28-32-26-15-14-25(34-24-8-7-9-24)16-27(26)33(28)23-17-29(3,4)19-30(5,6)18-23/h10-16,20,23-24H,7-9,17-19H2,1-6H3,(H,31,32)	CWCPCYPTYPWBQJ-UHFFFAOYSA-N	389531	US9951027, 3-165	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 140							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389531&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318444	404958120							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778175	CC(C)c1ccc(Nc2nc3ccc(OC4CCC4)cc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C29H39N3O/c1-19(2)21-9-11-22(12-10-21)30-28-31-26-14-13-25(33-24-7-6-8-24)16-27(26)32(28)23-15-20(3)17-29(4,5)18-23/h9-14,16,19-20,23-24H,6-8,15,17-18H2,1-5H3,(H,30,31)	XWOSICNXSQRLER-UHFFFAOYSA-N	389532	US9951027, 3-166	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 480							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389532	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389532&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318446	404958121							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778176	CC(C)c1ccc(Nc2nc3ccc(cc3n2C2CC(C)(C)CC(C)(C)C2)C#N)cc1	InChI=1S/C27H34N4/c1-18(2)20-8-10-21(11-9-20)29-25-30-23-12-7-19(16-28)13-24(23)31(25)22-14-26(3,4)17-27(5,6)15-22/h7-13,18,22H,14-15,17H2,1-6H3,(H,29,30)	SDSBEEFFKNOQOE-UHFFFAOYSA-N	389533	US9951027, 3-167	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 500							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389533&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311052	404958122							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778177	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C#N	InChI=1S/C25H27F3N4O/c1-23(2)12-18(13-24(3,4)15-23)32-21-11-16(14-29)5-10-20(21)31-22(32)30-17-6-8-19(9-7-17)33-25(26,27)28/h5-11,18H,12-13,15H2,1-4H3,(H,30,31)	NJVBFKDPJPNCPD-UHFFFAOYSA-N	389534	US9951027, 3-168	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389534&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318273	404958123							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778178	CC(C)c1ccc(Nc2nc3ccc(cc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)C#N)cc1 |r|	InChI=1S/C26H32N4/c1-17(2)20-7-9-21(10-8-20)28-25-29-23-11-6-19(16-27)13-24(23)30(25)22-12-18(3)14-26(4,5)15-22/h6-11,13,17-18,22H,12,14-15H2,1-5H3,(H,28,29)	JCRKTUJKLMNSMZ-UHFFFAOYSA-N	389535	US9951027, 3-169	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1900							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389535	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389535&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311043	404958124							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778179	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)C#N |r|	InChI=1S/C24H25F3N4O/c1-15-10-18(13-23(2,3)12-15)31-21-11-16(14-28)4-9-20(21)30-22(31)29-17-5-7-19(8-6-17)32-24(25,26)27/h4-9,11,15,18H,10,12-13H2,1-3H3,(H,29,30)	SLRZHZKIVSSQEJ-UHFFFAOYSA-N	389536	US9951027, 3-170	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389536	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389536&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318489	404958125							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778180	COc1cc(Nc2nc3cc(ccc3n2C2CC(C)CC(C)(C)C2)C(O)=O)cc(OC)c1OC	InChI=1S/C26H33N3O5/c1-15-9-18(14-26(2,3)13-15)29-20-8-7-16(24(30)31)10-19(20)28-25(29)27-17-11-21(32-4)23(34-6)22(12-17)33-5/h7-8,10-12,15,18H,9,13-14H2,1-6H3,(H,27,28)(H,30,31)	PZRMEQZKRQWAPK-UHFFFAOYSA-N	389537	US9951027, 3-171-2::US9951027, 3-171-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389537&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318276	404958126							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778181	COc1cc(Nc2nc3cc(ccc3n2C2CC(C)CC(C)(C)C2)C(O)=O)cc(OC)c1OC	InChI=1S/C26H33N3O5/c1-15-9-18(14-26(2,3)13-15)29-20-8-7-16(24(30)31)10-19(20)28-25(29)27-17-11-21(32-4)23(34-6)22(12-17)33-5/h7-8,10-12,15,18H,9,13-14H2,1-6H3,(H,27,28)(H,30,31)	PZRMEQZKRQWAPK-UHFFFAOYSA-N	389537	US9951027, 3-171-2::US9951027, 3-171-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 3200							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389537&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318276	404958126							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778182	CC(C)c1ccc(Nc2nc3c(F)cc(C)cc3n2C2CC(C)(C)CC(C)(C)C2)cc1	InChI=1S/C27H36FN3/c1-17(2)19-8-10-20(11-9-19)29-25-30-24-22(28)12-18(3)13-23(24)31(25)21-14-26(4,5)16-27(6,7)15-21/h8-13,17,21H,14-16H2,1-7H3,(H,29,30)	BEGLDNYMXXQYKG-UHFFFAOYSA-N	389539	US9951027, 3-172	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389539	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389539&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318451	404958127							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778183	CC(C)Oc1ccc(Nc2nc3c(F)cc(C)cc3n2C2CC(C)(C)CC(C)(C)C2)cc1	InChI=1S/C27H36FN3O/c1-17(2)32-21-10-8-19(9-11-21)29-25-30-24-22(28)12-18(3)13-23(24)31(25)20-14-26(4,5)16-27(6,7)15-20/h8-13,17,20H,14-16H2,1-7H3,(H,29,30)	KPVQGPUDOOZELF-UHFFFAOYSA-N	389540	US9951027, 3-173	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389540&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318453	404958128							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778184	Cc1cc(F)c2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2c1	InChI=1S/C25H29F4N3O/c1-15-10-19(26)21-20(11-15)32(17-12-23(2,3)14-24(4,5)13-17)22(31-21)30-16-6-8-18(9-7-16)33-25(27,28)29/h6-11,17H,12-14H2,1-5H3,(H,30,31)	VTDNZFYXVZXNFV-UHFFFAOYSA-N	389541	US9951027, 3-174	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 430							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389541&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318452	404958129							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778185	CC(C)c1ccc(Nc2nc3c(F)cc(C)cc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C26H34FN3/c1-16(2)19-7-9-20(10-8-19)28-25-29-24-22(27)12-17(3)13-23(24)30(25)21-11-18(4)14-26(5,6)15-21/h7-10,12-13,16,18,21H,11,14-15H2,1-6H3,(H,28,29)	OFOFMASLHUTCPE-UHFFFAOYSA-N	389542	US9951027, 3-175	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 50.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389542	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389542&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318487	404958130							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778186	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2c(F)cc(C)cc12 |r|	InChI=1S/C24H27F4N3O/c1-14-10-19(25)21-20(11-14)31(17-9-15(2)12-23(3,4)13-17)22(30-21)29-16-5-7-18(8-6-16)32-24(26,27)28/h5-8,10-11,15,17H,9,12-13H2,1-4H3,(H,29,30)	SEUIHBBBVGYVHT-UHFFFAOYSA-N	389543	US9951027, 3-176	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 60.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389543&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118314800	404958131							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778187	CC(C)c1ccc(Nc2nc3ccc(cc3n2C2CC(C)(C)CC(C)(C)C2)S(C)(=O)=O)cc1	InChI=1S/C27H37N3O2S/c1-18(2)19-8-10-20(11-9-19)28-25-29-23-13-12-22(33(7,31)32)14-24(23)30(25)21-15-26(3,4)17-27(5,6)16-21/h8-14,18,21H,15-17H2,1-7H3,(H,28,29)	HIGVCDMRPQRSDD-UHFFFAOYSA-N	389544	US9951027, 3-177	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 300							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389544&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318279	404958132							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778188	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)S(C)(=O)=O	InChI=1S/C25H30F3N3O3S/c1-23(2)13-17(14-24(3,4)15-23)31-21-12-19(35(5,32)33)10-11-20(21)30-22(31)29-16-6-8-18(9-7-16)34-25(26,27)28/h6-12,17H,13-15H2,1-5H3,(H,29,30)	PMLQPXMXFOOQSS-UHFFFAOYSA-N	389545	US9951027, 3-178	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1500							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389545&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318281	404958133							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778189	CC(C)Oc1ccc(Nc2nc3ccc(cc3n2C2CC(C)(C)CC(C)(C)C2)S(C)(=O)=O)cc1	InChI=1S/C27H37N3O3S/c1-18(2)33-21-10-8-19(9-11-21)28-25-29-23-13-12-22(34(7,31)32)14-24(23)30(25)20-15-26(3,4)17-27(5,6)16-20/h8-14,18,20H,15-17H2,1-7H3,(H,28,29)	ZLUJIKDBRCWCQL-UHFFFAOYSA-N	389546	US9951027, 3-179	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389546	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389546&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318610	404958134							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778190	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2ccc(cc12)S(C)(=O)=O |r|	InChI=1S/C24H28F3N3O3S/c1-15-11-17(14-23(2,3)13-15)30-21-12-19(34(4,31)32)9-10-20(21)29-22(30)28-16-5-7-18(8-6-16)33-24(25,26)27/h5-10,12,15,17H,11,13-14H2,1-4H3,(H,28,29)	KLGIQPUYSAYHME-UHFFFAOYSA-N	389547	US9951027, 3-180	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 950							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389547	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389547&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311137	404958135							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778191	CC(C)Oc1ccc(Nc2nc3ccc(cc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)S(C)(=O)=O)cc1 |r|	InChI=1S/C26H35N3O3S/c1-17(2)32-21-9-7-19(8-10-21)27-25-28-23-12-11-22(33(6,30)31)14-24(23)29(25)20-13-18(3)15-26(4,5)16-20/h7-12,14,17-18,20H,13,15-16H2,1-6H3,(H,27,28)	VNBNCPKVLFETKN-UHFFFAOYSA-N	389548	US9951027, 3-181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>37000							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389548&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318457	404958136							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778192	COc1cccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc12	InChI=1S/C27H37N3O/c1-18(2)19-11-13-20(14-12-19)28-25-29-24-22(9-8-10-23(24)31-7)30(25)21-15-26(3,4)17-27(5,6)16-21/h8-14,18,21H,15-17H2,1-7H3,(H,28,29)	WYBJUEFMJHFATN-UHFFFAOYSA-N	389549	US9951027, 3-182	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389549&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118311222	404958137							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778193	COc1cccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(C)C)cc3)nc12	InChI=1S/C27H37N3O2/c1-18(2)32-21-13-11-19(12-14-21)28-25-29-24-22(9-8-10-23(24)31-7)30(25)20-15-26(3,4)17-27(5,6)16-20/h8-14,18,20H,15-17H2,1-7H3,(H,28,29)	ZCRARPNRZPJEGG-UHFFFAOYSA-N	389550	US9951027, 3-183	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 100.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389550&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318580	404958138							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778194	COc1cccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc12	InChI=1S/C25H30F3N3O2/c1-23(2)13-17(14-24(3,4)15-23)31-19-7-6-8-20(32-5)21(19)30-22(31)29-16-9-11-18(12-10-16)33-25(26,27)28/h6-12,17H,13-15H2,1-5H3,(H,29,30)	POVYYTRQTJTCML-UHFFFAOYSA-N	389551	US9951027, 3-184	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389551&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318578	404958139							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778195	COc1cccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc12 |r|	InChI=1S/C26H35N3O/c1-17(2)19-10-12-20(13-11-19)27-25-28-24-22(8-7-9-23(24)30-6)29(25)21-14-18(3)15-26(4,5)16-21/h7-13,17-18,21H,14-16H2,1-6H3,(H,27,28)	JXXJOFVQBAVSET-UHFFFAOYSA-N	389552	US9951027, 3-185	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 50.0							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389552&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318579	404958140							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
778196	COc1cccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(C)C)cc3)nc12 |r|	InChI=1S/C26H35N3O2/c1-17(2)31-21-12-10-19(11-13-21)27-25-28-24-22(8-7-9-23(24)30-6)29(25)20-14-18(3)15-26(4,5)16-20/h7-13,17-18,20H,14-16H2,1-6H3,(H,27,28)	NVXMUMFRTLEHFQ-UHFFFAOYSA-N	389553	US9951027, 3-186	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 170							US Patent		10.7270/Q2S75JN6		aid1798782	US9951027	Rehwinkel, H; Siebeneicher, H; Anlauf, S; Nguyen, D; Panknin, O; Ring, S; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R	4/24/2018	3/16/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=389553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=389553&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318612	404958141							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780446	CC(C)(C)OC(=O)COc1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C30H38F3N3O4/c1-27(2,3)40-25(37)17-38-22-12-13-24-23(14-22)35-26(34-19-8-10-21(11-9-19)39-30(31,32)33)36(24)20-15-28(4,5)18-29(6,7)16-20/h8-14,20H,15-18H2,1-7H3,(H,34,35)	OOKABEGLDRDGKT-UHFFFAOYSA-N	390429	tert-butyl{[1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]-amino}-1H-benzimidazol-5-yl]oxy}acetate::US9957235, 2-8::US10442772, Example 2-8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 410							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390429	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390429&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318655	404959005							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780447	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(O)=O)ccc12	InChI=1S/C26H30F3N3O4/c1-24(2)12-17(13-25(3,4)15-24)32-21-10-9-19(35-14-22(33)34)11-20(21)31-23(32)30-16-5-7-18(8-6-16)36-26(27,28)29/h5-11,17H,12-15H2,1-4H3,(H,30,31)(H,33,34)	MHYIVXYCVBPRHQ-UHFFFAOYSA-N	390430	{[1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazol-5-yl]oxy}acetic acid::US9957235, 2-9::US10442772, Example 2-9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390430	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390430&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310598	404959006							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780448	COC(=O)\C=C\c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1 |r|	InChI=1S/C27H30F3N3O3/c1-17-13-20(16-26(2,3)15-17)33-23-11-5-18(6-12-24(34)35-4)14-22(23)32-25(33)31-19-7-9-21(10-8-19)36-27(28,29)30/h5-12,14,17,20H,13,15-16H2,1-4H3,(H,31,32)	ZIQTUZCDUOAFLM-UHFFFAOYSA-N	390431	(&#65533;) methyl (2E)-3-(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)acrylate::US9957235, 2-110	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 460							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390431	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390431&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318656	404959007							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780449	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(\C=C\C(O)=O)ccc12 |r|	InChI=1S/C26H28F3N3O3/c1-16-12-19(15-25(2,3)14-16)32-22-10-4-17(5-11-23(33)34)13-21(22)31-24(32)30-18-6-8-20(9-7-18)35-26(27,28)29/h4-11,13,16,19H,12,14-15H2,1-3H3,(H,30,31)(H,33,34)	ROYGJQDOOIPQNN-UHFFFAOYSA-N	390432	(&#65533;) (2E)-3-(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)acrylic acid::US9957235, 2-111::US10442772, Example 2-111-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390432	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390432&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310447	404959008							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780450	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(\C=C\C(O)=O)ccc12	InChI=1S/C26H28F3N3O3/c1-16-12-19(15-25(2,3)14-16)32-22-10-4-17(5-11-23(33)34)13-21(22)31-24(32)30-18-6-8-20(9-7-18)35-26(27,28)29/h4-11,13,16,19H,12,14-15H2,1-3H3,(H,30,31)(H,33,34)	ROYGJQDOOIPQNN-UHFFFAOYSA-N	390433	US9957235, 2-111-2::US9957235, 2-111-1::US10442772, Example 2-111-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390433	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390433&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310445	404959009							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780451	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(\C=C\C(O)=O)ccc12	InChI=1S/C26H28F3N3O3/c1-16-12-19(15-25(2,3)14-16)32-22-10-4-17(5-11-23(33)34)13-21(22)31-24(32)30-18-6-8-20(9-7-18)35-26(27,28)29/h4-11,13,16,19H,12,14-15H2,1-3H3,(H,30,31)(H,33,34)	ROYGJQDOOIPQNN-UHFFFAOYSA-N	390433	US9957235, 2-111-2::US9957235, 2-111-1::US10442772, Example 2-111-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 380							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390433	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390433&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310445	404959009							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780452	COC(=O)\C=C\c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(SC(F)(F)F)cc3)nc2c1 |r|	InChI=1S/C27H30F3N3O2S/c1-17-13-20(16-26(2,3)15-17)33-23-11-5-18(6-12-24(34)35-4)14-22(23)32-25(33)31-19-7-9-21(10-8-19)36-27(28,29)30/h5-12,14,17,20H,13,15-16H2,1-4H3,(H,31,32)	UZTDAWAOJICNLJ-UHFFFAOYSA-N	390435	(&#65533;) methyl (2E)-3-{2-({4-[(trifluoromethyl)sulfanyl]phenyl}amino)-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl}acrylate::US9957235, 2-112	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390435	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390435&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318931	404959010							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780453	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(SC(F)(F)F)cc2)nc2cc(\C=C\C(O)=O)ccc12 |r|	InChI=1S/C26H28F3N3O2S/c1-16-12-19(15-25(2,3)14-16)32-22-10-4-17(5-11-23(33)34)13-21(22)31-24(32)30-18-6-8-20(9-7-18)35-26(27,28)29/h4-11,13,16,19H,12,14-15H2,1-3H3,(H,30,31)(H,33,34)	YOPKCRBEEIVYRE-UHFFFAOYSA-N	390436	(&#65533;) (2E)-3-{2-({4-[(trifluoromethyl)sulfanyl]phenyl}amino)-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl}acrylic acid::US9957235, 2-113	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390436	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390436&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310630	404959011							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780454	COC(=O)CCc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(CC(F)(F)F)cc3)nc2c1 |r|	InChI=1S/C28H34F3N3O2/c1-18-13-22(17-27(2,3)15-18)34-24-11-7-19(8-12-25(35)36-4)14-23(24)33-26(34)32-21-9-5-20(6-10-21)16-28(29,30)31/h5-7,9-11,14,18,22H,8,12-13,15-17H2,1-4H3,(H,32,33)	SHRQPYYRMSJWMB-UHFFFAOYSA-N	390437	(&#65533;) methyl 3-(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanoate::US9957235, 2-114	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 300							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390437	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390437&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130209371	404959012							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780455	COC(=O)CCc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C27H32F3N3O3/c1-17-13-20(16-26(2,3)15-17)33-23-11-5-18(6-12-24(34)35-4)14-22(23)32-25(33)31-19-7-9-21(10-8-19)36-27(28,29)30/h5,7-11,14,17,20H,6,12-13,15-16H2,1-4H3,(H,31,32)	DGMNKGJNFMPOBU-UHFFFAOYSA-N	390438	US9957235, 2-114-2::US9957235, 2-114-1::US10442772, Example 2-114-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1730							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390438	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390438&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310303	404959013							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780456	COC(=O)CCc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C27H32F3N3O3/c1-17-13-20(16-26(2,3)15-17)33-23-11-5-18(6-12-24(34)35-4)14-22(23)32-25(33)31-19-7-9-21(10-8-19)36-27(28,29)30/h5,7-11,14,17,20H,6,12-13,15-16H2,1-4H3,(H,31,32)	DGMNKGJNFMPOBU-UHFFFAOYSA-N	390438	US9957235, 2-114-2::US9957235, 2-114-1::US10442772, Example 2-114-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 290							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390438	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390438&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310303	404959013							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780457	COC(=O)CCc1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(F)(F)F)nc2c1 |r|	InChI=1S/C27H32F3N3O2/c1-17-13-21(16-26(2,3)15-17)33-23-11-5-18(6-12-24(34)35-4)14-22(23)32-25(33)31-20-9-7-19(8-10-20)27(28,29)30/h5,7-11,14,17,21H,6,12-13,15-16H2,1-4H3,(H,31,32)	OEPQMGARKPEFEZ-UHFFFAOYSA-N	390440	(&#65533;) methyl 3-(2-{[4-(trifluoromethyl)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanoate::US9957235, 2-115::US10442772, Example 2-115-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 280							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390440	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390440&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310404	404959014							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780458	COC(=O)CCc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(F)(F)F)nc2c1	InChI=1S/C27H32F3N3O2/c1-17-13-21(16-26(2,3)15-17)33-23-11-5-18(6-12-24(34)35-4)14-22(23)32-25(33)31-20-9-7-19(8-10-20)27(28,29)30/h5,7-11,14,17,21H,6,12-13,15-16H2,1-4H3,(H,31,32)	OEPQMGARKPEFEZ-UHFFFAOYSA-N	390442	US9957235, 2-115-2::US9957235, 2-115-1::US10442772, Example 2-115-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2400							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390442	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390442&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310401	404959015							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780459	COC(=O)CCc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(F)(F)F)nc2c1	InChI=1S/C27H32F3N3O2/c1-17-13-21(16-26(2,3)15-17)33-23-11-5-18(6-12-24(34)35-4)14-22(23)32-25(33)31-20-9-7-19(8-10-20)27(28,29)30/h5,7-11,14,17,21H,6,12-13,15-16H2,1-4H3,(H,31,32)	OEPQMGARKPEFEZ-UHFFFAOYSA-N	390442	US9957235, 2-115-2::US9957235, 2-115-1::US10442772, Example 2-115-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 470							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390442	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390442&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310401	404959015							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780460	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(\C=C\C(N)=O)ccc12 |r|	InChI=1S/C26H29F3N4O2/c1-16-12-19(15-25(2,3)14-16)33-22-10-4-17(5-11-23(30)34)13-21(22)32-24(33)31-18-6-8-20(9-7-18)35-26(27,28)29/h4-11,13,16,19H,12,14-15H2,1-3H3,(H2,30,34)(H,31,32)	BPBZQZHGBXAQRE-UHFFFAOYSA-N	390445	(&#65533;) (2E)-3-(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)acrylamide::US9957235, 2-116::US10442772, Example 2-116-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 180							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390445&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310614	404959017							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780461	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(\C=C\C(N)=O)ccc12	InChI=1S/C26H29F3N4O2/c1-16-12-19(15-25(2,3)14-16)33-22-10-4-17(5-11-23(30)34)13-21(22)32-24(33)31-18-6-8-20(9-7-18)35-26(27,28)29/h4-11,13,16,19H,12,14-15H2,1-3H3,(H2,30,34)(H,31,32)	BPBZQZHGBXAQRE-UHFFFAOYSA-N	390446	US9957235, 2-116-2::US9957235, 2-116-1::US10442772, Example 2-116-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 290							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390446	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390446&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310613	404959018							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780462	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(\C=C\C(N)=O)ccc12	InChI=1S/C26H29F3N4O2/c1-16-12-19(15-25(2,3)14-16)33-22-10-4-17(5-11-23(30)34)13-21(22)32-24(33)31-18-6-8-20(9-7-18)35-26(27,28)29/h4-11,13,16,19H,12,14-15H2,1-3H3,(H2,30,34)(H,31,32)	BPBZQZHGBXAQRE-UHFFFAOYSA-N	390446	US9957235, 2-116-2::US9957235, 2-116-1::US10442772, Example 2-116-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390446	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390446&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310613	404959018							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780463	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(N)=O)ccc12 |r|	InChI=1S/C26H31F3N4O2/c1-16-12-19(15-25(2,3)14-16)33-22-10-4-17(5-11-23(30)34)13-21(22)32-24(33)31-18-6-8-20(9-7-18)35-26(27,28)29/h4,6-10,13,16,19H,5,11-12,14-15H2,1-3H3,(H2,30,34)(H,31,32)	WVTHRRRNMTVKDK-UHFFFAOYSA-N	390448	(&#65533;) 3-(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanamide::US9957235, 2-117	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390448	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390448&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310439	404959019							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780464	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(N)=O)ccc12	InChI=1S/C26H31F3N4O2/c1-16-12-19(15-25(2,3)14-16)33-22-10-4-17(5-11-23(30)34)13-21(22)32-24(33)31-18-6-8-20(9-7-18)35-26(27,28)29/h4,6-10,13,16,19H,5,11-12,14-15H2,1-3H3,(H2,30,34)(H,31,32)	WVTHRRRNMTVKDK-UHFFFAOYSA-N	390449	US9957235, 2-117-2::US9957235, 2-117-1::US10442772, Example 2-117-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 180							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390449	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390449&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310439	404959020							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780465	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(N)=O)ccc12	InChI=1S/C26H31F3N4O2/c1-16-12-19(15-25(2,3)14-16)33-22-10-4-17(5-11-23(30)34)13-21(22)32-24(33)31-18-6-8-20(9-7-18)35-26(27,28)29/h4,6-10,13,16,19H,5,11-12,14-15H2,1-3H3,(H2,30,34)(H,31,32)	WVTHRRRNMTVKDK-UHFFFAOYSA-N	390449	US9957235, 2-117-2::US9957235, 2-117-1::US10442772, Example 2-117-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390449	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390449&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310439	404959020							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780466	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(O)=O)ccc12 |r|	InChI=1S/C26H30F3N3O3/c1-16-12-19(15-25(2,3)14-16)32-22-10-4-17(5-11-23(33)34)13-21(22)31-24(32)30-18-6-8-20(9-7-18)35-26(27,28)29/h4,6-10,13,16,19H,5,11-12,14-15H2,1-3H3,(H,30,31)(H,33,34)	RNMAUIMMNAHKQR-UHFFFAOYSA-N	390451	(&#65533;) 3-(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanoic acid::US9957235, 2-118::US10442772, Example 2-118-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390451	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390451&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310258	404959021							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780467	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)F)cc2)nc2cc(CCC(O)=O)ccc12	InChI=1S/C26H31F2N3O3/c1-16-12-19(15-26(2,3)14-16)31-22-10-4-17(5-11-23(32)33)13-21(22)30-25(31)29-18-6-8-20(9-7-18)34-24(27)28/h4,6-10,13,16,19,24H,5,11-12,14-15H2,1-3H3,(H,29,30)(H,32,33)	GHHJBZAAAPFSQI-UHFFFAOYSA-N	390452	US9957235, 2-118-2::US9957235, 2-118-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 140							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390452	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390452&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011690	404959022							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780468	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)F)cc2)nc2cc(CCC(O)=O)ccc12	InChI=1S/C26H31F2N3O3/c1-16-12-19(15-26(2,3)14-16)31-22-10-4-17(5-11-23(32)33)13-21(22)30-25(31)29-18-6-8-20(9-7-18)34-24(27)28/h4,6-10,13,16,19,24H,5,11-12,14-15H2,1-3H3,(H,29,30)(H,32,33)	GHHJBZAAAPFSQI-UHFFFAOYSA-N	390452	US9957235, 2-118-2::US9957235, 2-118-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390452	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390452&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011690	404959022							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780469	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(CCC(O)=O)ccc12 |r|	InChI=1S/C26H30F3N3O2/c1-16-12-20(15-25(2,3)14-16)32-22-10-4-17(5-11-23(33)34)13-21(22)31-24(32)30-19-8-6-18(7-9-19)26(27,28)29/h4,6-10,13,16,20H,5,11-12,14-15H2,1-3H3,(H,30,31)(H,33,34)	SWIBIFMDDCTZKY-UHFFFAOYSA-N	390454	(&#65533;) 3-(2-{[4-(trifluoromethyl)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanoic acid::US9957235, 2-119	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390454	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390454&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310465	404959023							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780470	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(CCC(O)=O)ccc12	InChI=1S/C26H30F3N3O2/c1-16-12-20(15-25(2,3)14-16)32-22-10-4-17(5-11-23(33)34)13-21(22)31-24(32)30-19-8-6-18(7-9-19)26(27,28)29/h4,6-10,13,16,20H,5,11-12,14-15H2,1-3H3,(H,30,31)(H,33,34)	SWIBIFMDDCTZKY-UHFFFAOYSA-N	390455	US9957235, 2-119-2::US9957235, 2-119-1::US10442772, Example 2-119-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 130							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390455	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390455&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310465	404959024							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780471	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(CCC(O)=O)ccc12	InChI=1S/C26H30F3N3O2/c1-16-12-20(15-25(2,3)14-16)32-22-10-4-17(5-11-23(33)34)13-21(22)31-24(32)30-19-8-6-18(7-9-19)26(27,28)29/h4,6-10,13,16,20H,5,11-12,14-15H2,1-3H3,(H,30,31)(H,33,34)	SWIBIFMDDCTZKY-UHFFFAOYSA-N	390455	US9957235, 2-119-2::US9957235, 2-119-1::US10442772, Example 2-119-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390455	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390455&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310465	404959024							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780472	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(\C=C\C(=O)N(C)C)ccc12 |r|	InChI=1S/C28H33F3N4O2/c1-18-14-21(17-27(2,3)16-18)35-24-12-6-19(7-13-25(36)34(4)5)15-23(24)33-26(35)32-20-8-10-22(11-9-20)37-28(29,30)31/h6-13,15,18,21H,14,16-17H2,1-5H3,(H,32,33)	OWDIQEQGSDVURG-UHFFFAOYSA-N	390457	(&#65533;)-(2E)-N,N-dimethyl-3-(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)acrylamide::US9957235, 2-120::US10442772, Example 2-120	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 150							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390457	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390457&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310581	404959025							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780473	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(=O)N(C)C)ccc12 |r|	InChI=1S/C28H35F3N4O2/c1-18-14-21(17-27(2,3)16-18)35-24-12-6-19(7-13-25(36)34(4)5)15-23(24)33-26(35)32-20-8-10-22(11-9-20)37-28(29,30)31/h6,8-12,15,18,21H,7,13-14,16-17H2,1-5H3,(H,32,33)	UVLMERBLVWEXSO-UHFFFAOYSA-N	390458	(&#65533;) N,N-dimethyl-3-(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanamide::US9957235, 2-121::US10442772, Example 2-121	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 140							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390458	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390458&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310366	404959026							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780474	CCOc1ccc(Nc2nc3cc(OCC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C26H33N3O4/c1-5-32-20-8-6-18(7-9-20)27-25-28-22-13-21(33-16-24(30)31)10-11-23(22)29(25)19-12-17(2)14-26(3,4)15-19/h6-11,13,17,19H,5,12,14-16H2,1-4H3,(H,27,28)(H,30,31)	LFVIXRKGTLZJSO-UHFFFAOYSA-N	390459	(&#65533;) ({2-[(4-ethoxyphenyl)amino]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl}oxy)acetic acid::US9957235, 2-122::US10442772, Example 2-122	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390459	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390459&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310376	404959027							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780475	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(O)=O)ccc12	InChI=1S/C25H28F3N3O4/c1-15-10-17(13-24(2,3)12-15)31-21-9-8-19(34-14-22(32)33)11-20(21)30-23(31)29-16-4-6-18(7-5-16)35-25(26,27)28/h4-9,11,15,17H,10,12-14H2,1-3H3,(H,29,30)(H,32,33)	VKCVOKLTQODZLN-UHFFFAOYSA-N	390460	US9957235, 2-123-1::US9957235, 2-123::US10442772, Example 2-123-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390460	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390460&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310644	404959028							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780476	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(O)=O)ccc12	InChI=1S/C25H28F3N3O4/c1-15-10-17(13-24(2,3)12-15)31-21-9-8-19(34-14-22(32)33)11-20(21)30-23(31)29-16-4-6-18(7-5-16)35-25(26,27)28/h4-9,11,15,17H,10,12-14H2,1-3H3,(H,29,30)(H,32,33)	VKCVOKLTQODZLN-UHFFFAOYSA-N	390460	US9957235, 2-123-1::US9957235, 2-123::US10442772, Example 2-123-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390460	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390460&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310644	404959028							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780477	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(O)=O)ccc12	InChI=1S/C25H28F3N3O4/c1-15-10-17(13-24(2,3)12-15)31-21-9-8-19(34-14-22(32)33)11-20(21)30-23(31)29-16-4-6-18(7-5-16)35-25(26,27)28/h4-9,11,15,17H,10,12-14H2,1-3H3,(H,29,30)(H,32,33)	VKCVOKLTQODZLN-UHFFFAOYSA-N	390462	US9957235, 2-123-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 150							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390462	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390462&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310646	404959029							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780478	CC(C)Oc1ccc(Nc2nc3cc(OCC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C27H35N3O4/c1-17(2)34-21-8-6-19(7-9-21)28-26-29-23-13-22(33-16-25(31)32)10-11-24(23)30(26)20-12-18(3)14-27(4,5)15-20/h6-11,13,17-18,20H,12,14-16H2,1-5H3,(H,28,29)(H,31,32)	DLJQAEILEDAEPE-UHFFFAOYSA-N	390463	US9957235, 2-124	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390463	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390463&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310697	404959030							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780479	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C#N)nc2cc(OCC(O)=O)ccc12	InChI=1S/C25H28N4O3/c1-16-10-19(13-25(2,3)12-16)29-22-9-8-20(32-15-23(30)31)11-21(22)28-24(29)27-18-6-4-17(14-26)5-7-18/h4-9,11,16,19H,10,12-13,15H2,1-3H3,(H,27,28)(H,30,31)	ACYIYUMICDTELC-UHFFFAOYSA-N	390464	US9957235, 2-125	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 130							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390464	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390464&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310676	404959031							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780480	COC(=O)CNC(=O)COc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1 |r|	InChI=1S/C28H33F3N4O5/c1-17-11-19(14-27(2,3)13-17)35-23-10-9-21(39-16-24(36)32-15-25(37)38-4)12-22(23)34-26(35)33-18-5-7-20(8-6-18)40-28(29,30)31/h5-10,12,17,19H,11,13-16H2,1-4H3,(H,32,36)(H,33,34)	AMCIFUQYQHFRIO-UHFFFAOYSA-N	390465	(&#65533;) methyl N-{[(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)oxy]acetyl}glycinate::US9957235, 2-127::US10442772, Example 2-127	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 210							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390465	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390465&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310284	404959032							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780481	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(=O)NC3CC3)ccc12 |r|	InChI=1S/C28H33F3N4O3/c1-17-12-20(15-27(2,3)14-17)35-24-11-10-22(37-16-25(36)32-18-4-5-18)13-23(24)34-26(35)33-19-6-8-21(9-7-19)38-28(29,30)31/h6-11,13,17-18,20H,4-5,12,14-16H2,1-3H3,(H,32,36)(H,33,34)	KJTIRZVXMYRMLP-UHFFFAOYSA-N	390466	(&#65533;) N-cyclopropyl-2-[(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)oxy]acetamide::US9957235, 2-128::US10442772, Example 2-128-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 370							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390466	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390466&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310453	404959033							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780482	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(=O)NC3CC3)ccc12	InChI=1S/C28H33F3N4O3/c1-17-12-20(15-27(2,3)14-17)35-24-11-10-22(37-16-25(36)32-18-4-5-18)13-23(24)34-26(35)33-19-6-8-21(9-7-19)38-28(29,30)31/h6-11,13,17-18,20H,4-5,12,14-16H2,1-3H3,(H,32,36)(H,33,34)	KJTIRZVXMYRMLP-UHFFFAOYSA-N	390467	US9957235, 2-128-2::US9957235, 2-128-1::US10442772, Example 2-128-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 800							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390467	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390467&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310287	404959034							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780483	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(=O)NC3CC3)ccc12	InChI=1S/C28H33F3N4O3/c1-17-12-20(15-27(2,3)14-17)35-24-11-10-22(37-16-25(36)32-18-4-5-18)13-23(24)34-26(35)33-19-6-8-21(9-7-19)38-28(29,30)31/h6-11,13,17-18,20H,4-5,12,14-16H2,1-3H3,(H,32,36)(H,33,34)	KJTIRZVXMYRMLP-UHFFFAOYSA-N	390467	US9957235, 2-128-2::US9957235, 2-128-1::US10442772, Example 2-128-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 300							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390467	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390467&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310287	404959034							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780484	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(CC(F)(F)F)cc2)nc2cc(OCC(=O)NCC(O)=O)ccc12 |r|	InChI=1S/C28H33F3N4O4/c1-17-10-20(14-27(2,3)12-17)35-23-9-8-21(39-16-24(36)32-15-25(37)38)11-22(23)34-26(35)33-19-6-4-18(5-7-19)13-28(29,30)31/h4-9,11,17,20H,10,12-16H2,1-3H3,(H,32,36)(H,33,34)(H,37,38)	GGWMDEDIIJPVIO-UHFFFAOYSA-N	390469	(&#65533;) N-{[(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)oxy]acetyl}glycine::US9957235, 2-129	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 100.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390469	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390469&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130209372	404959035							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780485	COC(=O)CN(C)C(=O)COc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C29H35F3N4O5/c1-18-12-20(15-28(2,3)14-18)36-24-11-10-22(40-17-25(37)35(4)16-26(38)39-5)13-23(24)34-27(36)33-19-6-8-21(9-7-19)41-29(30,31)32/h6-11,13,18,20H,12,14-17H2,1-5H3,(H,33,34)	DNZXHFLBIWQXNE-UHFFFAOYSA-N	390470	US9957235, 2-130::US10442772, Example 2-130	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 420							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390470&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310480	404959036							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780486	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(=O)N(C)CC(O)=O)ccc12 |r|	InChI=1S/C28H33F3N4O5/c1-17-11-19(14-27(2,3)13-17)35-23-10-9-21(39-16-24(36)34(4)15-25(37)38)12-22(23)33-26(35)32-18-5-7-20(8-6-18)40-28(29,30)31/h5-10,12,17,19H,11,13-16H2,1-4H3,(H,32,33)(H,37,38)	HYEGARMRVAIGDN-UHFFFAOYSA-N	390471	(&#65533;)N-methyl-N-{[(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)oxy]acetyl}glycine::US9957235, 2-131	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 200							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390471	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390471&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310319	404959037							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780487	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCCCC(O)=O)ccc12 |r|	InChI=1S/C27H32F3N3O4/c1-17-13-19(16-26(2,3)15-17)33-23-11-10-21(36-12-4-5-24(34)35)14-22(23)32-25(33)31-18-6-8-20(9-7-18)37-27(28,29)30/h6-11,14,17,19H,4-5,12-13,15-16H2,1-3H3,(H,31,32)(H,34,35)	OJXRHXBBYSWYQU-UHFFFAOYSA-N	390472	(&#65533;) 4-[(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)oxy]butanoic acid::US9957235, 2-132::US10442772, Example 2-132-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390472	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390472&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310424	404959038							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780488	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)F)cc2)nc2cc(OCCCC(O)=O)ccc12	InChI=1S/C27H33F2N3O4/c1-17-13-19(16-27(2,3)15-17)32-23-11-10-21(35-12-4-5-24(33)34)14-22(23)31-26(32)30-18-6-8-20(9-7-18)36-25(28)29/h6-11,14,17,19,25H,4-5,12-13,15-16H2,1-3H3,(H,30,31)(H,33,34)	MNSCYSYNUWZXND-UHFFFAOYSA-N	390473	US9957235, 2-132-2::US9957235, 2-132-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 300							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390473&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011691	404959039							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780489	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)F)cc2)nc2cc(OCCCC(O)=O)ccc12	InChI=1S/C27H33F2N3O4/c1-17-13-19(16-27(2,3)15-17)32-23-11-10-21(35-12-4-5-24(33)34)14-22(23)31-26(32)30-18-6-8-20(9-7-18)36-25(28)29/h6-11,14,17,19,25H,4-5,12-13,15-16H2,1-3H3,(H,30,31)(H,33,34)	MNSCYSYNUWZXND-UHFFFAOYSA-N	390473	US9957235, 2-132-2::US9957235, 2-132-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 50.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390473&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011691	404959039							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780490	CC(C)c1ccc(Nc2nc3cc(OCCCC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C29H39N3O3/c1-19(2)21-8-10-22(11-9-21)30-28-31-25-16-24(35-14-6-7-27(33)34)12-13-26(25)32(28)23-15-20(3)17-29(4,5)18-23/h8-13,16,19-20,23H,6-7,14-15,17-18H2,1-5H3,(H,30,31)(H,33,34)	DINSIIZPPDOBKB-UHFFFAOYSA-N	390475	US9957235, 2-133-1::US9957235, 2-133-2::US9957235, 2-133::US10442772, Example 2-133-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390475&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310655	404959040							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780491	CC(C)c1ccc(Nc2nc3cc(OCCCC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C29H39N3O3/c1-19(2)21-8-10-22(11-9-21)30-28-31-25-16-24(35-14-6-7-27(33)34)12-13-26(25)32(28)23-15-20(3)17-29(4,5)18-23/h8-13,16,19-20,23H,6-7,14-15,17-18H2,1-5H3,(H,30,31)(H,33,34)	DINSIIZPPDOBKB-UHFFFAOYSA-N	390475	US9957235, 2-133-1::US9957235, 2-133-2::US9957235, 2-133::US10442772, Example 2-133-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 140							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390475&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310655	404959040							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780492	CC(C)c1ccc(Nc2nc3cc(OCCCC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C29H39N3O3/c1-19(2)21-8-10-22(11-9-21)30-28-31-25-16-24(35-14-6-7-27(33)34)12-13-26(25)32(28)23-15-20(3)17-29(4,5)18-23/h8-13,16,19-20,23H,6-7,14-15,17-18H2,1-5H3,(H,30,31)(H,33,34)	DINSIIZPPDOBKB-UHFFFAOYSA-N	390475	US9957235, 2-133-1::US9957235, 2-133-2::US9957235, 2-133::US10442772, Example 2-133-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390475&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310655	404959040							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780493	CC(C)Oc1ccc(Nc2nc3cc(OCCCC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C29H39N3O4/c1-19(2)36-23-10-8-21(9-11-23)30-28-31-25-16-24(35-14-6-7-27(33)34)12-13-26(25)32(28)22-15-20(3)17-29(4,5)18-22/h8-13,16,19-20,22H,6-7,14-15,17-18H2,1-5H3,(H,30,31)(H,33,34)	MUUIXNXJXMWHQB-UHFFFAOYSA-N	390478	US9957235, 2-135-1::US9957235, 2-135-2::US9957235, 2-135::US9957235, 2-134	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 250							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390478&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310492	404959041							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780494	CC(C)Oc1ccc(Nc2nc3cc(OCCCC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C29H39N3O4/c1-19(2)36-23-10-8-21(9-11-23)30-28-31-25-16-24(35-14-6-7-27(33)34)12-13-26(25)32(28)22-15-20(3)17-29(4,5)18-22/h8-13,16,19-20,22H,6-7,14-15,17-18H2,1-5H3,(H,30,31)(H,33,34)	MUUIXNXJXMWHQB-UHFFFAOYSA-N	390478	US9957235, 2-135-1::US9957235, 2-135-2::US9957235, 2-135::US9957235, 2-134	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 110							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390478&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310492	404959041							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780495	CC(C)Oc1ccc(Nc2nc3cc(OCCCC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C29H39N3O4/c1-19(2)36-23-10-8-21(9-11-23)30-28-31-25-16-24(35-14-6-7-27(33)34)12-13-26(25)32(28)22-15-20(3)17-29(4,5)18-22/h8-13,16,19-20,22H,6-7,14-15,17-18H2,1-5H3,(H,30,31)(H,33,34)	MUUIXNXJXMWHQB-UHFFFAOYSA-N	390478	US9957235, 2-135-1::US9957235, 2-135-2::US9957235, 2-135::US9957235, 2-134	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 600							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390478&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310492	404959041							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780496	CC(C)Oc1ccc(Nc2nc3cc(OCCCC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C29H39N3O4/c1-19(2)36-23-10-8-21(9-11-23)30-28-31-25-16-24(35-14-6-7-27(33)34)12-13-26(25)32(28)22-15-20(3)17-29(4,5)18-22/h8-13,16,19-20,22H,6-7,14-15,17-18H2,1-5H3,(H,30,31)(H,33,34)	MUUIXNXJXMWHQB-UHFFFAOYSA-N	390478	US9957235, 2-135-1::US9957235, 2-135-2::US9957235, 2-135::US9957235, 2-134	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390478&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310492	404959041							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780497	COC(=O)\C=C\c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(F)(F)F)nc2c1 |r|	InChI=1S/C27H30F3N3O2/c1-17-13-21(16-26(2,3)15-17)33-23-11-5-18(6-12-24(34)35-4)14-22(23)32-25(33)31-20-9-7-19(8-10-20)27(28,29)30/h5-12,14,17,21H,13,15-16H2,1-4H3,(H,31,32)	XHSKBCBUQNRTES-UHFFFAOYSA-N	390482	(&#65533;) methyl (2E)-3-(2-{[4-(trifluoromethyl)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)acrylate::US9957235, 2-138	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390482	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390482&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318626	404959042							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780498	COC(=O)\C=C\c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(F)(F)F)nc2c1	InChI=1S/C27H30F3N3O2/c1-17-13-21(16-26(2,3)15-17)33-23-11-5-18(6-12-24(34)35-4)14-22(23)32-25(33)31-20-9-7-19(8-10-20)27(28,29)30/h5-12,14,17,21H,13,15-16H2,1-4H3,(H,31,32)	XHSKBCBUQNRTES-UHFFFAOYSA-N	390484	US9957235, 2-138-2::US9957235, 2-138-1::US10442772, Example 2-138-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390484&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318625	404959043							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780499	COC(=O)\C=C\c1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(F)(F)F)nc2c1	InChI=1S/C27H30F3N3O2/c1-17-13-21(16-26(2,3)15-17)33-23-11-5-18(6-12-24(34)35-4)14-22(23)32-25(33)31-20-9-7-19(8-10-20)27(28,29)30/h5-12,14,17,21H,13,15-16H2,1-4H3,(H,31,32)	XHSKBCBUQNRTES-UHFFFAOYSA-N	390484	US9957235, 2-138-2::US9957235, 2-138-1::US10442772, Example 2-138-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 3700							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390484&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318625	404959043							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780500	COC(=O)CCc1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC(C)(C)C3)c2cc1C |r|	InChI=1S/C28H34F3N3O3/c1-17-12-21(16-27(3,4)15-17)34-24-13-18(2)19(6-11-25(35)36-5)14-23(24)33-26(34)32-20-7-9-22(10-8-20)37-28(29,30)31/h7-10,13-14,17,21H,6,11-12,15-16H2,1-5H3,(H,32,33)	GRHQUYSMNMGPTO-UHFFFAOYSA-N	390486	(&#65533;) methyl 3-(6-methyl-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanoate::US9957235, 2-158::US10442772, Example 2-158-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 50.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390486	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390486&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310365	404959044							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780501	COC(=O)CCc1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1C	InChI=1S/C28H34F3N3O3/c1-17-12-21(16-27(3,4)15-17)34-24-13-18(2)19(6-11-25(35)36-5)14-23(24)33-26(34)32-20-7-9-22(10-8-20)37-28(29,30)31/h7-10,13-14,17,21H,6,11-12,15-16H2,1-5H3,(H,32,33)	GRHQUYSMNMGPTO-UHFFFAOYSA-N	390487	US9957235, 2-158-2::US9957235, 2-158-1::US10442772, Example 2-158-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 440							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390487&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310363	404959045							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780502	COC(=O)CCc1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1C	InChI=1S/C28H34F3N3O3/c1-17-12-21(16-27(3,4)15-17)34-24-13-18(2)19(6-11-25(35)36-5)14-23(24)33-26(34)32-20-7-9-22(10-8-20)37-28(29,30)31/h7-10,13-14,17,21H,6,11-12,15-16H2,1-5H3,(H,32,33)	GRHQUYSMNMGPTO-UHFFFAOYSA-N	390487	US9957235, 2-158-2::US9957235, 2-158-1::US10442772, Example 2-158-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390487&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310363	404959045							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780503	COC(=O)CCc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(C)C)cc3)nc2c1	InChI=1S/C29H39N3O3/c1-19(2)35-24-11-9-22(10-12-24)30-28-31-25-16-21(8-14-27(33)34-6)7-13-26(25)32(28)23-15-20(3)17-29(4,5)18-23/h7,9-13,16,19-20,23H,8,14-15,17-18H2,1-6H3,(H,30,31)	NHGYQWOCLWSHKW-UHFFFAOYSA-N	390489	US9957235, 2-159::US10442772, Example 2-172-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 150							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390489&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319005	404959046							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780504	COC(=O)CCc1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1C	InChI=1S/C30H41N3O3/c1-19(2)36-25-11-9-23(10-12-25)31-29-32-26-16-22(8-13-28(34)35-7)21(4)15-27(26)33(29)24-14-20(3)17-30(5,6)18-24/h9-12,15-16,19-20,24H,8,13-14,17-18H2,1-7H3,(H,31,32)	ROSVXSYEBMTPHP-UHFFFAOYSA-N	390490	US9957235, 2-159-2::US9957235, 2-159-1::US10442772, Example 2-159-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 700							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390490&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310463	404959047							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780505	COC(=O)CCc1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1C	InChI=1S/C30H41N3O3/c1-19(2)36-25-11-9-23(10-12-25)31-29-32-26-16-22(8-13-28(34)35-7)21(4)15-27(26)33(29)24-14-20(3)17-30(5,6)18-24/h9-12,15-16,19-20,24H,8,13-14,17-18H2,1-7H3,(H,31,32)	ROSVXSYEBMTPHP-UHFFFAOYSA-N	390490	US9957235, 2-159-2::US9957235, 2-159-1::US10442772, Example 2-159-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 180							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390490&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310463	404959047							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780506	CC(C)c1ccc(Nc2nc3cc(CCC(O)=O)c(C)cc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C29H39N3O2/c1-18(2)21-7-10-23(11-8-21)30-28-31-25-15-22(9-12-27(33)34)20(4)14-26(25)32(28)24-13-19(3)16-29(5,6)17-24/h7-8,10-11,14-15,18-19,24H,9,12-13,16-17H2,1-6H3,(H,30,31)(H,33,34)	BHJVJIFGPZMTNN-UHFFFAOYSA-N	390492	US9957235, 2-164-2::US9957235, 2-164-1::US9957235, 2-160-2::US9957235, 2-160-1::US9957235, 2-164::US9957235, 2-160::US10442772, Example 2-164-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 50.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390492&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310556	404959048							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780507	CC(C)c1ccc(Nc2nc3cc(CCC(O)=O)c(C)cc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C29H39N3O2/c1-18(2)21-7-10-23(11-8-21)30-28-31-25-15-22(9-12-27(33)34)20(4)14-26(25)32(28)24-13-19(3)16-29(5,6)17-24/h7-8,10-11,14-15,18-19,24H,9,12-13,16-17H2,1-6H3,(H,30,31)(H,33,34)	BHJVJIFGPZMTNN-UHFFFAOYSA-N	390492	US9957235, 2-164-2::US9957235, 2-164-1::US9957235, 2-160-2::US9957235, 2-160-1::US9957235, 2-164::US9957235, 2-160::US10442772, Example 2-164-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 200							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390492&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310556	404959048							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780508	CC(C)c1ccc(Nc2nc3cc(CCC(O)=O)c(C)cc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C29H39N3O2/c1-18(2)21-7-10-23(11-8-21)30-28-31-25-15-22(9-12-27(33)34)20(4)14-26(25)32(28)24-13-19(3)16-29(5,6)17-24/h7-8,10-11,14-15,18-19,24H,9,12-13,16-17H2,1-6H3,(H,30,31)(H,33,34)	BHJVJIFGPZMTNN-UHFFFAOYSA-N	390492	US9957235, 2-164-2::US9957235, 2-164-1::US9957235, 2-160-2::US9957235, 2-160-1::US9957235, 2-164::US9957235, 2-160::US10442772, Example 2-164-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390492&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310556	404959048							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780509	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(CCC(O)=O)c(C)cc12	InChI=1S/C27H32F3N3O2/c1-16-11-21(15-26(3,4)14-16)33-23-12-17(2)18(5-10-24(34)35)13-22(23)32-25(33)31-20-8-6-19(7-9-20)27(28,29)30/h6-9,12-13,16,21H,5,10-11,14-15H2,1-4H3,(H,31,32)(H,34,35)	WYBQNXIIWGGTOU-UHFFFAOYSA-N	390495	US9957235, 2-165-1::US9957235, 2-165-2::US9957235, 2-161-1::US9957235, 2-165::US9957235, 2-161-2::US9957235, 2-161::US10442772, Example 2-165-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390495&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310626	404959049							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780510	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(CCC(O)=O)c(C)cc12	InChI=1S/C27H32F3N3O2/c1-16-11-21(15-26(3,4)14-16)33-23-12-17(2)18(5-10-24(34)35)13-22(23)32-25(33)31-20-8-6-19(7-9-20)27(28,29)30/h6-9,12-13,16,21H,5,10-11,14-15H2,1-4H3,(H,31,32)(H,34,35)	WYBQNXIIWGGTOU-UHFFFAOYSA-N	390495	US9957235, 2-165-1::US9957235, 2-165-2::US9957235, 2-161-1::US9957235, 2-165::US9957235, 2-161-2::US9957235, 2-161::US10442772, Example 2-165-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 750							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390495&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310626	404959049							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780511	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(CCC(O)=O)c(C)cc12	InChI=1S/C27H32F3N3O2/c1-16-11-21(15-26(3,4)14-16)33-23-12-17(2)18(5-10-24(34)35)13-22(23)32-25(33)31-20-8-6-19(7-9-20)27(28,29)30/h6-9,12-13,16,21H,5,10-11,14-15H2,1-4H3,(H,31,32)(H,34,35)	WYBQNXIIWGGTOU-UHFFFAOYSA-N	390495	US9957235, 2-165-1::US9957235, 2-165-2::US9957235, 2-161-1::US9957235, 2-165::US9957235, 2-161-2::US9957235, 2-161::US10442772, Example 2-165-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390495&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310626	404959049							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780512	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(O)=O)c(C)cc12 |r|	InChI=1S/C27H32F3N3O3/c1-16-11-20(15-26(3,4)14-16)33-23-12-17(2)18(5-10-24(34)35)13-22(23)32-25(33)31-19-6-8-21(9-7-19)36-27(28,29)30/h6-9,12-13,16,20H,5,10-11,14-15H2,1-4H3,(H,31,32)(H,34,35)	LXLGZKRGTAWWOQ-UHFFFAOYSA-N	390498	(&#65533;) 3-(6-methyl-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanoic acid::US9957235, 2-162::US10442772, Example 2-162-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390498	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390498&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310293	404959050							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780513	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(O)=O)c(C)cc12	InChI=1S/C27H32F3N3O3/c1-16-11-20(15-26(3,4)14-16)33-23-12-17(2)18(5-10-24(34)35)13-22(23)32-25(33)31-19-6-8-21(9-7-19)36-27(28,29)30/h6-9,12-13,16,20H,5,10-11,14-15H2,1-4H3,(H,31,32)(H,34,35)	LXLGZKRGTAWWOQ-UHFFFAOYSA-N	390499	US9957235, 2-162-2::US9957235, 2-162-1::US10442772, Example 2-162-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390499	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390499&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310291	404959051							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780514	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(O)=O)c(C)cc12	InChI=1S/C27H32F3N3O3/c1-16-11-20(15-26(3,4)14-16)33-23-12-17(2)18(5-10-24(34)35)13-22(23)32-25(33)31-19-6-8-21(9-7-19)36-27(28,29)30/h6-9,12-13,16,20H,5,10-11,14-15H2,1-4H3,(H,31,32)(H,34,35)	LXLGZKRGTAWWOQ-UHFFFAOYSA-N	390499	US9957235, 2-162-2::US9957235, 2-162-1::US10442772, Example 2-162-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 9.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390499	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390499&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310291	404959051							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780515	CC(C)Oc1ccc(Nc2nc3cc(CCC(O)=O)c(C)cc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C29H39N3O3/c1-18(2)35-24-10-8-22(9-11-24)30-28-31-25-15-21(7-12-27(33)34)20(4)14-26(25)32(28)23-13-19(3)16-29(5,6)17-23/h8-11,14-15,18-19,23H,7,12-13,16-17H2,1-6H3,(H,30,31)(H,33,34)	DBFNZXUFQWQKRE-UHFFFAOYSA-N	390501	US9957235, 2-163-2::US9957235, 2-163-1::US9957235, 2-163::US10442772, Example 2-163-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390501&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318675	404959052							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780516	CC(C)Oc1ccc(Nc2nc3cc(CCC(O)=O)c(C)cc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C29H39N3O3/c1-18(2)35-24-10-8-22(9-11-24)30-28-31-25-15-21(7-12-27(33)34)20(4)14-26(25)32(28)23-13-19(3)16-29(5,6)17-23/h8-11,14-15,18-19,23H,7,12-13,16-17H2,1-6H3,(H,30,31)(H,33,34)	DBFNZXUFQWQKRE-UHFFFAOYSA-N	390501	US9957235, 2-163-2::US9957235, 2-163-1::US9957235, 2-163::US10442772, Example 2-163-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 60.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390501&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318675	404959052							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780517	CC(C)Oc1ccc(Nc2nc3cc(CCC(O)=O)c(C)cc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C29H39N3O3/c1-18(2)35-24-10-8-22(9-11-24)30-28-31-25-15-21(7-12-27(33)34)20(4)14-26(25)32(28)23-13-19(3)16-29(5,6)17-23/h8-11,14-15,18-19,23H,7,12-13,16-17H2,1-6H3,(H,30,31)(H,33,34)	DBFNZXUFQWQKRE-UHFFFAOYSA-N	390501	US9957235, 2-163-2::US9957235, 2-163-1::US9957235, 2-163::US10442772, Example 2-163-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390501&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318675	404959052							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780518	CC(C)c1ccc(Nc2nc3cc(CCC(O)=O)c(C)cc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C29H39N3O2/c1-18(2)21-7-10-23(11-8-21)30-28-31-25-15-22(9-12-27(33)34)20(4)14-26(25)32(28)24-13-19(3)16-29(5,6)17-24/h7-8,10-11,14-15,18-19,24H,9,12-13,16-17H2,1-6H3,(H,30,31)(H,33,34)	BHJVJIFGPZMTNN-UHFFFAOYSA-N	390492	US9957235, 2-164-2::US9957235, 2-164-1::US9957235, 2-160-2::US9957235, 2-160-1::US9957235, 2-164::US9957235, 2-160::US10442772, Example 2-164-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390492&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310556	404959048							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780519	CC(C)c1ccc(Nc2nc3cc(CCC(O)=O)c(C)cc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C29H39N3O2/c1-18(2)21-7-10-23(11-8-21)30-28-31-25-15-22(9-12-27(33)34)20(4)14-26(25)32(28)24-13-19(3)16-29(5,6)17-24/h7-8,10-11,14-15,18-19,24H,9,12-13,16-17H2,1-6H3,(H,30,31)(H,33,34)	BHJVJIFGPZMTNN-UHFFFAOYSA-N	390492	US9957235, 2-164-2::US9957235, 2-164-1::US9957235, 2-160-2::US9957235, 2-160-1::US9957235, 2-164::US9957235, 2-160::US10442772, Example 2-164-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390492&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310556	404959048							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780520	CC(C)c1ccc(Nc2nc3cc(CCC(O)=O)c(C)cc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C29H39N3O2/c1-18(2)21-7-10-23(11-8-21)30-28-31-25-15-22(9-12-27(33)34)20(4)14-26(25)32(28)24-13-19(3)16-29(5,6)17-24/h7-8,10-11,14-15,18-19,24H,9,12-13,16-17H2,1-6H3,(H,30,31)(H,33,34)	BHJVJIFGPZMTNN-UHFFFAOYSA-N	390492	US9957235, 2-164-2::US9957235, 2-164-1::US9957235, 2-160-2::US9957235, 2-160-1::US9957235, 2-164::US9957235, 2-160::US10442772, Example 2-164-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390492&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310556	404959048							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780521	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(CCC(O)=O)c(C)cc12	InChI=1S/C27H32F3N3O2/c1-16-11-21(15-26(3,4)14-16)33-23-12-17(2)18(5-10-24(34)35)13-22(23)32-25(33)31-20-8-6-19(7-9-20)27(28,29)30/h6-9,12-13,16,21H,5,10-11,14-15H2,1-4H3,(H,31,32)(H,34,35)	WYBQNXIIWGGTOU-UHFFFAOYSA-N	390495	US9957235, 2-165-1::US9957235, 2-165-2::US9957235, 2-161-1::US9957235, 2-165::US9957235, 2-161-2::US9957235, 2-161::US10442772, Example 2-165-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390495&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310626	404959049							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780522	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(CCC(O)=O)c(C)cc12	InChI=1S/C27H32F3N3O2/c1-16-11-21(15-26(3,4)14-16)33-23-12-17(2)18(5-10-24(34)35)13-22(23)32-25(33)31-20-8-6-19(7-9-20)27(28,29)30/h6-9,12-13,16,21H,5,10-11,14-15H2,1-4H3,(H,31,32)(H,34,35)	WYBQNXIIWGGTOU-UHFFFAOYSA-N	390495	US9957235, 2-165-1::US9957235, 2-165-2::US9957235, 2-161-1::US9957235, 2-165::US9957235, 2-161-2::US9957235, 2-161::US10442772, Example 2-165-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390495&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310626	404959049							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780523	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(CCC(O)=O)c(C)cc12	InChI=1S/C27H32F3N3O2/c1-16-11-21(15-26(3,4)14-16)33-23-12-17(2)18(5-10-24(34)35)13-22(23)32-25(33)31-20-8-6-19(7-9-20)27(28,29)30/h6-9,12-13,16,21H,5,10-11,14-15H2,1-4H3,(H,31,32)(H,34,35)	WYBQNXIIWGGTOU-UHFFFAOYSA-N	390495	US9957235, 2-165-1::US9957235, 2-165-2::US9957235, 2-161-1::US9957235, 2-165::US9957235, 2-161-2::US9957235, 2-161::US10442772, Example 2-165-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390495&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310626	404959049							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780524	COC(=O)CCc1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC |r|	InChI=1S/C28H34F3N3O4/c1-17-12-20(16-27(2,3)15-17)34-23-14-24(36-4)18(6-11-25(35)37-5)13-22(23)33-26(34)32-19-7-9-21(10-8-19)38-28(29,30)31/h7-10,13-14,17,20H,6,11-12,15-16H2,1-5H3,(H,32,33)	LTABNFUFNXASOF-UHFFFAOYSA-N	390510	US9957235, 2-166-2::US9957235, 2-166-1::(&#65533;) methyl 3-(6-methoxy-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanoate::US9957235, 2-166::US10442772, Example 2-166-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 60.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390510&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310275	404959053							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780525	COC(=O)CCc1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC |r|	InChI=1S/C28H34F3N3O4/c1-17-12-20(16-27(2,3)15-17)34-23-14-24(36-4)18(6-11-25(35)37-5)13-22(23)33-26(34)32-19-7-9-21(10-8-19)38-28(29,30)31/h7-10,13-14,17,20H,6,11-12,15-16H2,1-5H3,(H,32,33)	LTABNFUFNXASOF-UHFFFAOYSA-N	390510	US9957235, 2-166-2::US9957235, 2-166-1::(&#65533;) methyl 3-(6-methoxy-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanoate::US9957235, 2-166::US10442772, Example 2-166-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 260							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390510&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310275	404959053							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780526	COC(=O)CCc1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC |r|	InChI=1S/C28H34F3N3O4/c1-17-12-20(16-27(2,3)15-17)34-23-14-24(36-4)18(6-11-25(35)37-5)13-22(23)33-26(34)32-19-7-9-21(10-8-19)38-28(29,30)31/h7-10,13-14,17,20H,6,11-12,15-16H2,1-5H3,(H,32,33)	LTABNFUFNXASOF-UHFFFAOYSA-N	390510	US9957235, 2-166-2::US9957235, 2-166-1::(&#65533;) methyl 3-(6-methoxy-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanoate::US9957235, 2-166::US10442772, Example 2-166-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 50.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390510&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310275	404959053							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780527	COC(=O)CCc1cc2nc(Nc3ccc(cc3)C(C)C)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C30H41N3O3/c1-19(2)21-8-11-23(12-9-21)31-29-32-25-15-22(10-13-28(34)36-7)27(35-6)16-26(25)33(29)24-14-20(3)17-30(4,5)18-24/h8-9,11-12,15-16,19-20,24H,10,13-14,17-18H2,1-7H3,(H,31,32)	DGNGFHHYESDYEV-UHFFFAOYSA-N	390513	US9957235, 2-167-2::US9957235, 2-167-1::US9957235, 2-167::US10442772, Example 2-167-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390513&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310491	404959054							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780528	COC(=O)CCc1cc2nc(Nc3ccc(cc3)C(C)C)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C30H41N3O3/c1-19(2)21-8-11-23(12-9-21)31-29-32-25-15-22(10-13-28(34)36-7)27(35-6)16-26(25)33(29)24-14-20(3)17-30(4,5)18-24/h8-9,11-12,15-16,19-20,24H,10,13-14,17-18H2,1-7H3,(H,31,32)	DGNGFHHYESDYEV-UHFFFAOYSA-N	390513	US9957235, 2-167-2::US9957235, 2-167-1::US9957235, 2-167::US10442772, Example 2-167-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 170							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390513&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310491	404959054							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780529	COC(=O)CCc1cc2nc(Nc3ccc(cc3)C(C)C)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C30H41N3O3/c1-19(2)21-8-11-23(12-9-21)31-29-32-25-15-22(10-13-28(34)36-7)27(35-6)16-26(25)33(29)24-14-20(3)17-30(4,5)18-24/h8-9,11-12,15-16,19-20,24H,10,13-14,17-18H2,1-7H3,(H,31,32)	DGNGFHHYESDYEV-UHFFFAOYSA-N	390513	US9957235, 2-167-2::US9957235, 2-167-1::US9957235, 2-167::US10442772, Example 2-167-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390513	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390513&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310491	404959054							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780530	COC(=O)CCc1cc2nc(Nc3ccc(cc3)C(F)(F)F)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C28H34F3N3O3/c1-17-12-21(16-27(2,3)15-17)34-23-14-24(36-4)18(6-11-25(35)37-5)13-22(23)33-26(34)32-20-9-7-19(8-10-20)28(29,30)31/h7-10,13-14,17,21H,6,11-12,15-16H2,1-5H3,(H,32,33)	GGUUFXLYCUMTGO-UHFFFAOYSA-N	390516	US9957235, 2-168-2::US9957235, 2-168-1::US9957235, 2-168::US10442772, Example 2-168-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 100.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390516&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310505	404959055							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780531	COC(=O)CCc1cc2nc(Nc3ccc(cc3)C(F)(F)F)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C28H34F3N3O3/c1-17-12-21(16-27(2,3)15-17)34-23-14-24(36-4)18(6-11-25(35)37-5)13-22(23)33-26(34)32-20-9-7-19(8-10-20)28(29,30)31/h7-10,13-14,17,21H,6,11-12,15-16H2,1-5H3,(H,32,33)	GGUUFXLYCUMTGO-UHFFFAOYSA-N	390516	US9957235, 2-168-2::US9957235, 2-168-1::US9957235, 2-168::US10442772, Example 2-168-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 950							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390516&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310505	404959055							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780532	COC(=O)CCc1cc2nc(Nc3ccc(cc3)C(F)(F)F)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C28H34F3N3O3/c1-17-12-21(16-27(2,3)15-17)34-23-14-24(36-4)18(6-11-25(35)37-5)13-22(23)33-26(34)32-20-9-7-19(8-10-20)28(29,30)31/h7-10,13-14,17,21H,6,11-12,15-16H2,1-5H3,(H,32,33)	GGUUFXLYCUMTGO-UHFFFAOYSA-N	390516	US9957235, 2-168-2::US9957235, 2-168-1::US9957235, 2-168::US10442772, Example 2-168-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 60.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390516&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310505	404959055							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780533	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1CCC(O)=O |r|	InChI=1S/C27H32F3N3O4/c1-16-11-19(15-26(2,3)14-16)33-22-13-23(36-4)17(5-10-24(34)35)12-21(22)32-25(33)31-18-6-8-20(9-7-18)37-27(28,29)30/h6-9,12-13,16,19H,5,10-11,14-15H2,1-4H3,(H,31,32)(H,34,35)	RRIGKXHXERNTDY-UHFFFAOYSA-N	390519	(&#65533;) 3-(6-methoxy-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanoic acid::US9957235, 2-169	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390519&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310352	404959056							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780534	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1CCC(O)=O	InChI=1S/C27H32F3N3O4/c1-16-11-19(15-26(2,3)14-16)33-22-13-23(36-4)17(5-10-24(34)35)12-21(22)32-25(33)31-18-6-8-20(9-7-18)37-27(28,29)30/h6-9,12-13,16,19H,5,10-11,14-15H2,1-4H3,(H,31,32)(H,34,35)	RRIGKXHXERNTDY-UHFFFAOYSA-N	390520	US9957235, 2-169-2::US9957235, 2-169-1::US10442772, Example 2-169-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390520&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310352	404959057							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780535	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1CCC(O)=O	InChI=1S/C27H32F3N3O4/c1-16-11-19(15-26(2,3)14-16)33-22-13-23(36-4)17(5-10-24(34)35)12-21(22)32-25(33)31-18-6-8-20(9-7-18)37-27(28,29)30/h6-9,12-13,16,19H,5,10-11,14-15H2,1-4H3,(H,31,32)(H,34,35)	RRIGKXHXERNTDY-UHFFFAOYSA-N	390520	US9957235, 2-169-2::US9957235, 2-169-1::US10442772, Example 2-169-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390520&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310352	404959057							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780536	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(O)=O)nc2cc1CCC(O)=O	InChI=1S/C27H33N3O5/c1-16-11-20(15-27(2,3)14-16)30-22-13-23(35-4)18(7-10-24(31)32)12-21(22)29-26(30)28-19-8-5-17(6-9-19)25(33)34/h5-6,8-9,12-13,16,20H,7,10-11,14-15H2,1-4H3,(H,28,29)(H,31,32)(H,33,34)	IUJCCIXEWIUFEB-UHFFFAOYSA-N	390522	US9957235, 2-170-2::US9957235, 2-178::US9957235, 2-170-1::US9957235, 2-170	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 8.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390522&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310750	404959058							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780537	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(O)=O)nc2cc1CCC(O)=O	InChI=1S/C27H33N3O5/c1-16-11-20(15-27(2,3)14-16)30-22-13-23(35-4)18(7-10-24(31)32)12-21(22)29-26(30)28-19-8-5-17(6-9-19)25(33)34/h5-6,8-9,12-13,16,20H,7,10-11,14-15H2,1-4H3,(H,28,29)(H,31,32)(H,33,34)	IUJCCIXEWIUFEB-UHFFFAOYSA-N	390522	US9957235, 2-170-2::US9957235, 2-178::US9957235, 2-170-1::US9957235, 2-170	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390522&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310750	404959058							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780538	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(O)=O)nc2cc1CCC(O)=O	InChI=1S/C27H33N3O5/c1-16-11-20(15-27(2,3)14-16)30-22-13-23(35-4)18(7-10-24(31)32)12-21(22)29-26(30)28-19-8-5-17(6-9-19)25(33)34/h5-6,8-9,12-13,16,20H,7,10-11,14-15H2,1-4H3,(H,28,29)(H,31,32)(H,33,34)	IUJCCIXEWIUFEB-UHFFFAOYSA-N	390522	US9957235, 2-170-2::US9957235, 2-178::US9957235, 2-170-1::US9957235, 2-170	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 9.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390522&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310750	404959058							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780539	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(F)(F)F)nc2cc1CCC(O)=O	InChI=1S/C27H32F3N3O3/c1-16-11-20(15-26(2,3)14-16)33-22-13-23(36-4)17(5-10-24(34)35)12-21(22)32-25(33)31-19-8-6-18(7-9-19)27(28,29)30/h6-9,12-13,16,20H,5,10-11,14-15H2,1-4H3,(H,31,32)(H,34,35)	GCGATJCXUINDSU-UHFFFAOYSA-N	390525	US9957235, 2-171-1::US9957235, 2-171-2::US9957235, 2-171::US10442772, Example 2-171-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390525&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310310	404959059							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780540	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(F)(F)F)nc2cc1CCC(O)=O	InChI=1S/C27H32F3N3O3/c1-16-11-20(15-26(2,3)14-16)33-22-13-23(36-4)17(5-10-24(34)35)12-21(22)32-25(33)31-19-8-6-18(7-9-19)27(28,29)30/h6-9,12-13,16,20H,5,10-11,14-15H2,1-4H3,(H,31,32)(H,34,35)	GCGATJCXUINDSU-UHFFFAOYSA-N	390525	US9957235, 2-171-1::US9957235, 2-171-2::US9957235, 2-171::US10442772, Example 2-171-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390525&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310310	404959059							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780541	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(F)(F)F)nc2cc1CCC(O)=O	InChI=1S/C27H32F3N3O3/c1-16-11-20(15-26(2,3)14-16)33-22-13-23(36-4)17(5-10-24(34)35)12-21(22)32-25(33)31-19-8-6-18(7-9-19)27(28,29)30/h6-9,12-13,16,20H,5,10-11,14-15H2,1-4H3,(H,31,32)(H,34,35)	GCGATJCXUINDSU-UHFFFAOYSA-N	390525	US9957235, 2-171-1::US9957235, 2-171-2::US9957235, 2-171::US10442772, Example 2-171-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 9.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390525&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310310	404959059							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780542	CC(C)c1ccc(Nc2nc3cc(CCC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C28H37N3O2/c1-18(2)21-8-10-22(11-9-21)29-27-30-24-15-20(7-13-26(32)33)6-12-25(24)31(27)23-14-19(3)16-28(4,5)17-23/h6,8-12,15,18-19,23H,7,13-14,16-17H2,1-5H3,(H,29,30)(H,32,33)	UAYCJDYGIDLXRD-UHFFFAOYSA-N	390528	US9957235, 2-175-1::US9957235, 2-175-2::US9957235, 2-175::US9957235, 2-172-1::US9957235, 2-172::US10442772, Example 2-175-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 500							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390528&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310385	404959060							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780543	CC(C)c1ccc(Nc2nc3cc(CCC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C28H37N3O2/c1-18(2)21-8-10-22(11-9-21)29-27-30-24-15-20(7-13-26(32)33)6-12-25(24)31(27)23-14-19(3)16-28(4,5)17-23/h6,8-12,15,18-19,23H,7,13-14,16-17H2,1-5H3,(H,29,30)(H,32,33)	UAYCJDYGIDLXRD-UHFFFAOYSA-N	390528	US9957235, 2-175-1::US9957235, 2-175-2::US9957235, 2-175::US9957235, 2-172-1::US9957235, 2-172::US10442772, Example 2-175-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1600							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390528&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310385	404959060							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780544	CC(C)c1ccc(Nc2nc3cc(CCC(O)=O)ccc3n2[C@H]2CC(C)CC(C)(C)C2)cc1	InChI=1S/C28H37N3O2/c1-18(2)21-8-10-22(11-9-21)29-27-30-24-15-20(7-13-26(32)33)6-12-25(24)31(27)23-14-19(3)16-28(4,5)17-23/h6,8-12,15,18-19,23H,7,13-14,16-17H2,1-5H3,(H,29,30)(H,32,33)	UAYCJDYGIDLXRD-UHFFFAOYSA-N	390530	US9957235, 2-172-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 500							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390530&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011692	404959061							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780545	COC(=O)CCc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C29H39N3O2/c1-19(2)22-9-11-23(12-10-22)30-28-31-25-16-21(8-14-27(33)34-6)7-13-26(25)32(28)24-15-20(3)17-29(4,5)18-24/h7,9-13,16,19-20,24H,8,14-15,17-18H2,1-6H3,(H,30,31)	FBUWHYCWLWSUQD-UHFFFAOYSA-N	390531	US9957235, 2-173-1::US9957235, 2-173-2::US9957235, 2-173::US10442772, Example 2-173-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 170							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390531&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318660	404959062							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780546	COC(=O)CCc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C29H39N3O2/c1-19(2)22-9-11-23(12-10-22)30-28-31-25-16-21(8-14-27(33)34-6)7-13-26(25)32(28)24-15-20(3)17-29(4,5)18-24/h7,9-13,16,19-20,24H,8,14-15,17-18H2,1-6H3,(H,30,31)	FBUWHYCWLWSUQD-UHFFFAOYSA-N	390531	US9957235, 2-173-1::US9957235, 2-173-2::US9957235, 2-173::US10442772, Example 2-173-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1100							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390531&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318660	404959062							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780547	COC(=O)CCc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C29H39N3O2/c1-19(2)22-9-11-23(12-10-22)30-28-31-25-16-21(8-14-27(33)34-6)7-13-26(25)32(28)24-15-20(3)17-29(4,5)18-24/h7,9-13,16,19-20,24H,8,14-15,17-18H2,1-6H3,(H,30,31)	FBUWHYCWLWSUQD-UHFFFAOYSA-N	390531	US9957235, 2-173-1::US9957235, 2-173-2::US9957235, 2-173::US10442772, Example 2-173-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 100.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390531&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318660	404959062							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780548	CC(C)Oc1ccc(Nc2nc3cc(CCC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C28H37N3O3/c1-18(2)34-23-10-8-21(9-11-23)29-27-30-24-15-20(7-13-26(32)33)6-12-25(24)31(27)22-14-19(3)16-28(4,5)17-22/h6,8-12,15,18-19,22H,7,13-14,16-17H2,1-5H3,(H,29,30)(H,32,33)	AYBJXJLBRDNWBW-UHFFFAOYSA-N	390534	US9957235, 2-174-2::US9957235, 2-174-1::US9957235, 2-174::US10442772, Example 2-174-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 60.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390534&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310602	404959063							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780549	CC(C)Oc1ccc(Nc2nc3cc(CCC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C28H37N3O3/c1-18(2)34-23-10-8-21(9-11-23)29-27-30-24-15-20(7-13-26(32)33)6-12-25(24)31(27)22-14-19(3)16-28(4,5)17-22/h6,8-12,15,18-19,22H,7,13-14,16-17H2,1-5H3,(H,29,30)(H,32,33)	AYBJXJLBRDNWBW-UHFFFAOYSA-N	390534	US9957235, 2-174-2::US9957235, 2-174-1::US9957235, 2-174::US10442772, Example 2-174-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 140							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390534&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310602	404959063							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780550	CC(C)Oc1ccc(Nc2nc3cc(CCC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C28H37N3O3/c1-18(2)34-23-10-8-21(9-11-23)29-27-30-24-15-20(7-13-26(32)33)6-12-25(24)31(27)22-14-19(3)16-28(4,5)17-22/h6,8-12,15,18-19,22H,7,13-14,16-17H2,1-5H3,(H,29,30)(H,32,33)	AYBJXJLBRDNWBW-UHFFFAOYSA-N	390534	US9957235, 2-174-2::US9957235, 2-174-1::US9957235, 2-174::US10442772, Example 2-174-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 60.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390534&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310602	404959063							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780551	CC(C)c1ccc(Nc2nc3cc(CCC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C28H37N3O2/c1-18(2)21-8-10-22(11-9-21)29-27-30-24-15-20(7-13-26(32)33)6-12-25(24)31(27)23-14-19(3)16-28(4,5)17-23/h6,8-12,15,18-19,23H,7,13-14,16-17H2,1-5H3,(H,29,30)(H,32,33)	UAYCJDYGIDLXRD-UHFFFAOYSA-N	390528	US9957235, 2-175-1::US9957235, 2-175-2::US9957235, 2-175::US9957235, 2-172-1::US9957235, 2-172::US10442772, Example 2-175-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390528&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310385	404959060							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780552	CC(C)c1ccc(Nc2nc3cc(CCC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C28H37N3O2/c1-18(2)21-8-10-22(11-9-21)29-27-30-24-15-20(7-13-26(32)33)6-12-25(24)31(27)23-14-19(3)16-28(4,5)17-23/h6,8-12,15,18-19,23H,7,13-14,16-17H2,1-5H3,(H,29,30)(H,32,33)	UAYCJDYGIDLXRD-UHFFFAOYSA-N	390528	US9957235, 2-175-1::US9957235, 2-175-2::US9957235, 2-175::US9957235, 2-172-1::US9957235, 2-172::US10442772, Example 2-175-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390528&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310385	404959060							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780553	CC(C)c1ccc(Nc2nc3cc(CCC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C28H37N3O2/c1-18(2)21-8-10-22(11-9-21)29-27-30-24-15-20(7-13-26(32)33)6-12-25(24)31(27)23-14-19(3)16-28(4,5)17-23/h6,8-12,15,18-19,23H,7,13-14,16-17H2,1-5H3,(H,29,30)(H,32,33)	UAYCJDYGIDLXRD-UHFFFAOYSA-N	390528	US9957235, 2-175-1::US9957235, 2-175-2::US9957235, 2-175::US9957235, 2-172-1::US9957235, 2-172::US10442772, Example 2-175-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 9.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390528&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310385	404959060							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780554	COC(=O)CCc1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C30H41N3O4/c1-19(2)37-24-11-9-22(10-12-24)31-29-32-25-15-21(8-13-28(34)36-7)27(35-6)16-26(25)33(29)23-14-20(3)17-30(4,5)18-23/h9-12,15-16,19-20,23H,8,13-14,17-18H2,1-7H3,(H,31,32)	JITOOGQCCZXDRG-UHFFFAOYSA-N	390540	US9957235, 2-176-2::US9957235, 2-176-1::US9957235, 2-176::US10442772, Example 2-176-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 170							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390540&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310564	404959064							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780555	COC(=O)CCc1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C30H41N3O4/c1-19(2)37-24-11-9-22(10-12-24)31-29-32-25-15-21(8-13-28(34)36-7)27(35-6)16-26(25)33(29)23-14-20(3)17-30(4,5)18-23/h9-12,15-16,19-20,23H,8,13-14,17-18H2,1-7H3,(H,31,32)	JITOOGQCCZXDRG-UHFFFAOYSA-N	390540	US9957235, 2-176-2::US9957235, 2-176-1::US9957235, 2-176::US10442772, Example 2-176-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 600							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390540&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310564	404959064							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780556	COC(=O)CCc1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C30H41N3O4/c1-19(2)37-24-11-9-22(10-12-24)31-29-32-25-15-21(8-13-28(34)36-7)27(35-6)16-26(25)33(29)23-14-20(3)17-30(4,5)18-23/h9-12,15-16,19-20,23H,8,13-14,17-18H2,1-7H3,(H,31,32)	JITOOGQCCZXDRG-UHFFFAOYSA-N	390540	US9957235, 2-176-2::US9957235, 2-176-1::US9957235, 2-176::US10442772, Example 2-176-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 90.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390540&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310564	404959064							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780557	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2cc1CCC(O)=O	InChI=1S/C29H39N3O3/c1-18(2)20-7-10-22(11-8-20)30-28-31-24-14-21(9-12-27(33)34)26(35-6)15-25(24)32(28)23-13-19(3)16-29(4,5)17-23/h7-8,10-11,14-15,18-19,23H,9,12-13,16-17H2,1-6H3,(H,30,31)(H,33,34)	LPPDJFQKLXOTAS-UHFFFAOYSA-N	390543	US9957235, 2-177-1::US9957235, 2-177-2::US9957235, 2-177::US10442772, Example 2-170-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390543&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319006	404959065							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780558	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2cc1CCC(O)=O	InChI=1S/C29H39N3O3/c1-18(2)20-7-10-22(11-8-20)30-28-31-24-14-21(9-12-27(33)34)26(35-6)15-25(24)32(28)23-13-19(3)16-29(4,5)17-23/h7-8,10-11,14-15,18-19,23H,9,12-13,16-17H2,1-6H3,(H,30,31)(H,33,34)	LPPDJFQKLXOTAS-UHFFFAOYSA-N	390543	US9957235, 2-177-1::US9957235, 2-177-2::US9957235, 2-177::US10442772, Example 2-170-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 100.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390543&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319006	404959065							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780559	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2cc1CCC(O)=O	InChI=1S/C29H39N3O3/c1-18(2)20-7-10-22(11-8-20)30-28-31-24-14-21(9-12-27(33)34)26(35-6)15-25(24)32(28)23-13-19(3)16-29(4,5)17-23/h7-8,10-11,14-15,18-19,23H,9,12-13,16-17H2,1-6H3,(H,30,31)(H,33,34)	LPPDJFQKLXOTAS-UHFFFAOYSA-N	390543	US9957235, 2-177-1::US9957235, 2-177-2::US9957235, 2-177::US10442772, Example 2-170-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390543&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319006	404959065							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780560	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(O)=O)nc2cc1CCC(O)=O	InChI=1S/C27H33N3O5/c1-16-11-20(15-27(2,3)14-16)30-22-13-23(35-4)18(7-10-24(31)32)12-21(22)29-26(30)28-19-8-5-17(6-9-19)25(33)34/h5-6,8-9,12-13,16,20H,7,10-11,14-15H2,1-4H3,(H,28,29)(H,31,32)(H,33,34)	IUJCCIXEWIUFEB-UHFFFAOYSA-N	390522	US9957235, 2-170-2::US9957235, 2-178::US9957235, 2-170-1::US9957235, 2-170	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 500							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390522&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310750	404959058							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780561	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(=O)NCc3ncccc3C(F)(F)F)ccc12 |r|	InChI=1S/C32H33F6N5O3/c1-19-13-21(16-30(2,3)15-19)43-27-11-10-23(45-18-28(44)40-17-26-24(31(33,34)35)5-4-12-39-26)14-25(27)42-29(43)41-20-6-8-22(9-7-20)46-32(36,37)38/h4-12,14,19,21H,13,15-18H2,1-3H3,(H,40,44)(H,41,42)	ZIVTUSQPZICGHH-UHFFFAOYSA-N	390547	(&#65533;) 2-[(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)oxy]-N-{[3-(trifluoromethyl)pyridin-2-yl]methyl}acetamide::US9957235, 2-179::US10442772, Example 2-179	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390547	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390547&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310417	404959066							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780562	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(=O)Nc3ccccc3Cl)ccc12	InChI=1S/C31H32ClF3N4O3/c1-19-14-21(17-30(2,3)16-19)39-27-13-12-23(41-18-28(40)37-25-7-5-4-6-24(25)32)15-26(27)38-29(39)36-20-8-10-22(11-9-20)42-31(33,34)35/h4-13,15,19,21H,14,16-18H2,1-3H3,(H,36,38)(H,37,40)	QHGLOAVXKVNAGX-UHFFFAOYSA-N	390548	US9957235, 2-180	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390548&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310604	404959067							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780563	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(=O)NCc3ncccc3C)ccc12	InChI=1S/C32H36F3N5O3/c1-20-14-23(17-31(3,4)16-20)40-28-12-11-25(42-19-29(41)37-18-27-21(2)6-5-13-36-27)15-26(28)39-30(40)38-22-7-9-24(10-8-22)43-32(33,34)35/h5-13,15,20,23H,14,16-19H2,1-4H3,(H,37,41)(H,38,39)	YAZADNINUDFOOB-UHFFFAOYSA-N	390549	US9957235, 2-181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 3000							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390549&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310705	404959068							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780564	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(=O)NCc3ncccc3C)ccc12	InChI=1S/C32H36F3N5O3/c1-20-14-23(17-31(3,4)16-20)40-28-12-11-25(42-19-29(41)37-18-27-21(2)6-5-13-36-27)15-26(28)39-30(40)38-22-7-9-24(10-8-22)43-32(33,34)35/h5-13,15,20,23H,14,16-19H2,1-4H3,(H,37,41)(H,38,39)	YAZADNINUDFOOB-UHFFFAOYSA-N	390550	US9957235, 2-182::US10442772, Example 2-181	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2000							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390550&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310672	404959069							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780565	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(=O)NCc3ncc(cc3Cl)C(F)(F)F)ccc12	InChI=1S/C32H32ClF6N5O3/c1-18-10-21(14-30(2,3)13-18)44-27-9-8-23(46-17-28(45)41-16-26-24(33)11-19(15-40-26)31(34,35)36)12-25(27)43-29(44)42-20-4-6-22(7-5-20)47-32(37,38)39/h4-9,11-12,15,18,21H,10,13-14,16-17H2,1-3H3,(H,41,45)(H,42,43)	FIHIIWCCNZNBIB-UHFFFAOYSA-N	390551	US9957235, 2-184::US9957235, 2-183	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 700							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390551&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310619	404959070							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780566	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(=O)NCc3ncc(cc3Cl)C(F)(F)F)ccc12	InChI=1S/C32H32ClF6N5O3/c1-18-10-21(14-30(2,3)13-18)44-27-9-8-23(46-17-28(45)41-16-26-24(33)11-19(15-40-26)31(34,35)36)12-25(27)43-29(44)42-20-4-6-22(7-5-20)47-32(37,38)39/h4-9,11-12,15,18,21H,10,13-14,16-17H2,1-3H3,(H,41,45)(H,42,43)	FIHIIWCCNZNBIB-UHFFFAOYSA-N	390551	US9957235, 2-184::US9957235, 2-183	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 4100							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390551&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310619	404959070							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780567	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(=O)Nc3cccc(OC(F)(F)F)c3)ccc12	InChI=1S/C32H32F6N4O4/c1-19-13-22(17-30(2,3)16-19)42-27-12-11-24(44-18-28(43)39-21-5-4-6-25(14-21)46-32(36,37)38)15-26(27)41-29(42)40-20-7-9-23(10-8-20)45-31(33,34)35/h4-12,14-15,19,22H,13,16-18H2,1-3H3,(H,39,43)(H,40,41)	HOJYZKPZTXYXDC-UHFFFAOYSA-N	390553	US9957235, 2-185	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1600							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390553&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310395	404959071							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780568	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(=O)Nc3ccc(cc3)C(F)(F)F)ccc12	InChI=1S/C32H32F6N4O3/c1-19-14-23(17-30(2,3)16-19)42-27-13-12-25(44-18-28(43)39-21-6-4-20(5-7-21)31(33,34)35)15-26(27)41-29(42)40-22-8-10-24(11-9-22)45-32(36,37)38/h4-13,15,19,23H,14,16-18H2,1-3H3,(H,39,43)(H,40,41)	WPBKQKKZHPCQAJ-UHFFFAOYSA-N	390554	US9957235, 2-186	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10000							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390554&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310587	404959072							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780569	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(=O)Nc3cccc(c3)C(F)(F)F)ccc12	InChI=1S/C32H32F6N4O3/c1-19-13-23(17-30(2,3)16-19)42-27-12-11-25(44-18-28(43)39-22-6-4-5-20(14-22)31(33,34)35)15-26(27)41-29(42)40-21-7-9-24(10-8-21)45-32(36,37)38/h4-12,14-15,19,23H,13,16-18H2,1-3H3,(H,39,43)(H,40,41)	QSXHXLCRBCVIQX-UHFFFAOYSA-N	390555	US9957235, 2-187	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 4100							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390555&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310544	404959073							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780570	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(=O)Nc3cccc(OC(F)F)c3)ccc12	InChI=1S/C32H33F5N4O4/c1-19-13-22(17-31(2,3)16-19)41-27-12-11-24(43-18-28(42)38-21-5-4-6-25(14-21)44-29(33)34)15-26(27)40-30(41)39-20-7-9-23(10-8-20)45-32(35,36)37/h4-12,14-15,19,22,29H,13,16-18H2,1-3H3,(H,38,42)(H,39,40)	VSNINFZKANJEHW-UHFFFAOYSA-N	390556	US9957235, 2-188	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 4000							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390556&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310588	404959074							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780571	COC(=O)c1cccc(NC(=O)COc2ccc3n([C@H]4C[C@@H](C)CC(C)(C)C4)c(Nc4ccc(OC(F)(F)F)cc4)nc3c2)c1	InChI=1S/C33H35F3N4O5/c1-20-14-24(18-32(2,3)17-20)40-28-13-12-26(44-19-29(41)37-23-7-5-6-21(15-23)30(42)43-4)16-27(28)39-31(40)38-22-8-10-25(11-9-22)45-33(34,35)36/h5-13,15-16,20,24H,14,17-19H2,1-4H3,(H,37,41)(H,38,39)	HCVNUQFNOKDAOE-UHFFFAOYSA-N	390557	US9957235, 2-189	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 7100							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390557&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319031	404959075							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780572	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(=O)Nc3cc(OC(F)F)ccc3Cl)ccc12	InChI=1S/C32H32ClF5N4O4/c1-18-12-20(16-31(2,3)15-18)42-27-11-9-22(44-17-28(43)40-25-14-23(45-29(34)35)8-10-24(25)33)13-26(27)41-30(42)39-19-4-6-21(7-5-19)46-32(36,37)38/h4-11,13-14,18,20,29H,12,15-17H2,1-3H3,(H,39,41)(H,40,43)	IJZIMGCAAJSZSL-UHFFFAOYSA-N	390558	US9957235, 2-190	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10000							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390558&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			130203446	404959076							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780573	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(=O)Nc3ccc(OC(F)F)cc3)ccc12	InChI=1S/C32H33F5N4O4/c1-19-14-22(17-31(2,3)16-19)41-27-13-12-25(43-18-28(42)38-20-4-8-23(9-5-20)44-29(33)34)15-26(27)40-30(41)39-21-6-10-24(11-7-21)45-32(35,36)37/h4-13,15,19,22,29H,14,16-18H2,1-3H3,(H,38,42)(H,39,40)	HSYPXVRTRFDFDS-UHFFFAOYSA-N	390559	US9957235, 2-191	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2500							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390559&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310509	404959077							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780574	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(=O)Nc3ccccc3C)ccc12	InChI=1S/C32H35F3N4O3/c1-20-15-23(18-31(3,4)17-20)39-28-14-13-25(41-19-29(40)37-26-8-6-5-7-21(26)2)16-27(28)38-30(39)36-22-9-11-24(12-10-22)42-32(33,34)35/h5-14,16,20,23H,15,17-19H2,1-4H3,(H,36,38)(H,37,40)	MCAGIWLCGMHAKF-UHFFFAOYSA-N	390560	US9957235, 2-192	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5800							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390560&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310461	404959078							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780575	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(=O)Nc3cccc(C)c3)ccc12	InChI=1S/C32H35F3N4O3/c1-20-6-5-7-23(14-20)36-29(40)19-41-26-12-13-28-27(16-26)38-30(39(28)24-15-21(2)17-31(3,4)18-24)37-22-8-10-25(11-9-22)42-32(33,34)35/h5-14,16,21,24H,15,17-19H2,1-4H3,(H,36,40)(H,37,38)	KPJXRSATMSPSCK-UHFFFAOYSA-N	390561	US9957235, 2-193	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10000							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390561&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310498	404959079							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780576	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(OCC(=O)Nc3ccc(OC(F)(F)F)cc3)ccc12	InChI=1S/C32H32F6N4O4/c1-19-14-22(17-30(2,3)16-19)42-27-13-12-25(44-18-28(43)39-20-4-8-23(9-5-20)45-31(33,34)35)15-26(27)41-29(42)40-21-6-10-24(11-7-21)46-32(36,37)38/h4-13,15,19,22H,14,16-18H2,1-3H3,(H,39,43)(H,40,41)	IEGFMJPZAQZCIR-UHFFFAOYSA-N	390562	US9957235, 2-194	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		>10000							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390562	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390562&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310362	404959080							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780577	COC(=O)Cc1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C27H32F3N3O3/c1-25(2)14-19(15-26(3,4)16-25)33-22-11-6-17(13-23(34)35-5)12-21(22)32-24(33)31-18-7-9-20(10-8-18)36-27(28,29)30/h6-12,19H,13-16H2,1-5H3,(H,31,32)	QZVIALLTRMLOMY-UHFFFAOYSA-N	390563	US9957235, 2-195::US10442772, Example 2-195	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 100.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390563&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318663	404959081							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780578	COC(=O)Cc1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(C)C)cc3)nc2c1	InChI=1S/C29H39N3O3/c1-19(2)35-23-11-9-21(10-12-23)30-27-31-24-14-20(15-26(33)34-7)8-13-25(24)32(27)22-16-28(3,4)18-29(5,6)17-22/h8-14,19,22H,15-18H2,1-7H3,(H,30,31)	BOVUYJRCPWJPLV-UHFFFAOYSA-N	390564	US9957235, 2-196::US10442772, Example 2-196	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 90.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390564&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318664	404959082							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780579	COC(=O)Cc1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C29H39N3O2/c1-19(2)21-9-11-22(12-10-21)30-27-31-24-14-20(15-26(33)34-7)8-13-25(24)32(27)23-16-28(3,4)18-29(5,6)17-23/h8-14,19,23H,15-18H2,1-7H3,(H,30,31)	UZFJOPNTNFOVQF-UHFFFAOYSA-N	390565	US9957235, 2-197::US10442772, Example 2-197	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390565&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318665	404959083							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780580	COC(=O)Cc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C28H37N3O2/c1-18(2)21-8-10-22(11-9-21)29-27-30-24-14-20(15-26(32)33-6)7-12-25(24)31(27)23-13-19(3)16-28(4,5)17-23/h7-12,14,18-19,23H,13,15-17H2,1-6H3,(H,29,30)	BWQVSPBOCNDZFI-UHFFFAOYSA-N	390566	US9957235, 2-219::US9957235, 2-198-2::US9957235, 2-198-1::US9957235, 2-219-1::US9957235, 2-219-2::US9957235, 2-198::US10442772, Example 2-198-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390566&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319035	404959084							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780581	COC(=O)Cc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C28H37N3O2/c1-18(2)21-8-10-22(11-9-21)29-27-30-24-14-20(15-26(32)33-6)7-12-25(24)31(27)23-13-19(3)16-28(4,5)17-23/h7-12,14,18-19,23H,13,15-17H2,1-6H3,(H,29,30)	BWQVSPBOCNDZFI-UHFFFAOYSA-N	390566	US9957235, 2-219::US9957235, 2-198-2::US9957235, 2-198-1::US9957235, 2-219-1::US9957235, 2-219-2::US9957235, 2-198::US10442772, Example 2-198-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 480							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390566&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319035	404959084							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780582	COC(=O)Cc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C28H37N3O2/c1-18(2)21-8-10-22(11-9-21)29-27-30-24-14-20(15-26(32)33-6)7-12-25(24)31(27)23-13-19(3)16-28(4,5)17-23/h7-12,14,18-19,23H,13,15-17H2,1-6H3,(H,29,30)	BWQVSPBOCNDZFI-UHFFFAOYSA-N	390566	US9957235, 2-219::US9957235, 2-198-2::US9957235, 2-198-1::US9957235, 2-219-1::US9957235, 2-219-2::US9957235, 2-198::US10442772, Example 2-198-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390566&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319035	404959084							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780583	CC(C)Oc1ccc(Nc2nc3cc(CC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C27H35N3O3/c1-17(2)33-22-9-7-20(8-10-22)28-26-29-23-13-19(14-25(31)32)6-11-24(23)30(26)21-12-18(3)15-27(4,5)16-21/h6-11,13,17-18,21H,12,14-16H2,1-5H3,(H,28,29)(H,31,32)	PWIWVXULADEBKS-UHFFFAOYSA-N	390569	US9957235, 2-199-2::US9957235, 2-199-1::US9957235, 2-199::US10442772, Example 2-226-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 230							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390569&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310621	404959085							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780584	CC(C)Oc1ccc(Nc2nc3cc(CC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C27H35N3O3/c1-17(2)33-22-9-7-20(8-10-22)28-26-29-23-13-19(14-25(31)32)6-11-24(23)30(26)21-12-18(3)15-27(4,5)16-21/h6-11,13,17-18,21H,12,14-16H2,1-5H3,(H,28,29)(H,31,32)	PWIWVXULADEBKS-UHFFFAOYSA-N	390569	US9957235, 2-199-2::US9957235, 2-199-1::US9957235, 2-199::US10442772, Example 2-226-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 620							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390569&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310621	404959085							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780585	CC(C)Oc1ccc(Nc2nc3cc(CC(O)=O)ccc3n2[C@H]2C[C@@H](C)CC(C)(C)C2)cc1	InChI=1S/C27H35N3O3/c1-17(2)33-22-9-7-20(8-10-22)28-26-29-23-13-19(14-25(31)32)6-11-24(23)30(26)21-12-18(3)15-27(4,5)16-21/h6-11,13,17-18,21H,12,14-16H2,1-5H3,(H,28,29)(H,31,32)	PWIWVXULADEBKS-UHFFFAOYSA-N	390569	US9957235, 2-199-2::US9957235, 2-199-1::US9957235, 2-199::US10442772, Example 2-226-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 170							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390569&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310621	404959085							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780586	COC(=O)Cc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C26H30F3N3O3/c1-16-11-19(15-25(2,3)14-16)32-22-10-5-17(13-23(33)34-4)12-21(22)31-24(32)30-18-6-8-20(9-7-18)35-26(27,28)29/h5-10,12,16,19H,11,13-15H2,1-4H3,(H,30,31)	WZJGKLSUFRIGRL-UHFFFAOYSA-N	390572	US9957235, 2-200-1::US9957235, 2-200-2::US9957235, 2-200::US10442772, Example 2-200-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 200							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390572&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318668	404959086							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780587	COC(=O)Cc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C26H30F3N3O3/c1-16-11-19(15-25(2,3)14-16)32-22-10-5-17(13-23(33)34-4)12-21(22)31-24(32)30-18-6-8-20(9-7-18)35-26(27,28)29/h5-10,12,16,19H,11,13-15H2,1-4H3,(H,30,31)	WZJGKLSUFRIGRL-UHFFFAOYSA-N	390572	US9957235, 2-200-1::US9957235, 2-200-2::US9957235, 2-200::US10442772, Example 2-200-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 420							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390572&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318668	404959086							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780588	COC(=O)Cc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C26H30F3N3O3/c1-16-11-19(15-25(2,3)14-16)32-22-10-5-17(13-23(33)34-4)12-21(22)31-24(32)30-18-6-8-20(9-7-18)35-26(27,28)29/h5-10,12,16,19H,11,13-15H2,1-4H3,(H,30,31)	WZJGKLSUFRIGRL-UHFFFAOYSA-N	390572	US9957235, 2-200-1::US9957235, 2-200-2::US9957235, 2-200::US10442772, Example 2-200-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390572&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318668	404959086							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780589	COC(=O)CCc1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C28H34F3N3O3/c1-26(2)15-20(16-27(3,4)17-26)34-23-12-6-18(7-13-24(35)36-5)14-22(23)33-25(34)32-19-8-10-21(11-9-19)37-28(29,30)31/h6,8-12,14,20H,7,13,15-17H2,1-5H3,(H,32,33)	XHSUGIZGEBSRNX-UHFFFAOYSA-N	390575	US9957235, 2-201::US10442772, Example 2-201	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 180							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390575&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319025	404959087							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780590	COC(=O)Cc1cc2nc(Nc3ccc(OC(C)C)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2cc1C	InChI=1S/C30H41N3O3/c1-19(2)36-24-11-9-22(10-12-24)31-28-32-25-14-21(15-27(34)35-8)20(3)13-26(25)33(28)23-16-29(4,5)18-30(6,7)17-23/h9-14,19,23H,15-18H2,1-8H3,(H,31,32)	MMWDRQMGLBEWPR-UHFFFAOYSA-N	390576	US9957235, 2-202::US10442772, Example 2-202	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 60.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390576&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318728	404959088							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780591	COC(=O)Cc1cc2nc(Nc3ccc(cc3)C(C)C)n(C3CC(C)(C)CC(C)(C)C3)c2cc1C	InChI=1S/C30H41N3O2/c1-19(2)21-9-11-23(12-10-21)31-28-32-25-14-22(15-27(34)35-8)20(3)13-26(25)33(28)24-16-29(4,5)18-30(6,7)17-24/h9-14,19,24H,15-18H2,1-8H3,(H,31,32)	GLMDIGVBYFXSHC-UHFFFAOYSA-N	390577	US9957235, 2-203::US10442772, Example 2-203	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390577&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318729	404959089							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780592	COC(=O)Cc1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2cc1C	InChI=1S/C28H34F3N3O3/c1-17-11-23-22(12-18(17)13-24(35)36-6)33-25(32-19-7-9-21(10-8-19)37-28(29,30)31)34(23)20-14-26(2,3)16-27(4,5)15-20/h7-12,20H,13-16H2,1-6H3,(H,32,33)	FFRIXSVOZIDDAK-UHFFFAOYSA-N	390578	US9957235, 2-204::US10442772, Example 2-204	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 50.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390578&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318726	404959090							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780593	COC(=O)Cc1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1C	InChI=1S/C29H39N3O3/c1-18(2)35-24-10-8-22(9-11-24)30-28-31-25-14-21(15-27(33)34-7)20(4)13-26(25)32(28)23-12-19(3)16-29(5,6)17-23/h8-11,13-14,18-19,23H,12,15-17H2,1-7H3,(H,30,31)	DPQGOOSBZZICGU-UHFFFAOYSA-N	390579	US9957235, 2-205-2::US9957235, 2-205-1::US9957235, 2-205::US10442772, Example 2-205-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390579&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319024	404959091							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780594	COC(=O)Cc1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1C	InChI=1S/C29H39N3O3/c1-18(2)35-24-10-8-22(9-11-24)30-28-31-25-14-21(15-27(33)34-7)20(4)13-26(25)32(28)23-12-19(3)16-29(5,6)17-23/h8-11,13-14,18-19,23H,12,15-17H2,1-7H3,(H,30,31)	DPQGOOSBZZICGU-UHFFFAOYSA-N	390579	US9957235, 2-205-2::US9957235, 2-205-1::US9957235, 2-205::US10442772, Example 2-205-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 380							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390579&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319024	404959091							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780595	COC(=O)Cc1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1C	InChI=1S/C29H39N3O3/c1-18(2)35-24-10-8-22(9-11-24)30-28-31-25-14-21(15-27(33)34-7)20(4)13-26(25)32(28)23-12-19(3)16-29(5,6)17-23/h8-11,13-14,18-19,23H,12,15-17H2,1-7H3,(H,30,31)	DPQGOOSBZZICGU-UHFFFAOYSA-N	390579	US9957235, 2-205-2::US9957235, 2-205-1::US9957235, 2-205::US10442772, Example 2-205-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 50.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390579&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319024	404959091							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780596	COC(=O)Cc1cc2nc(Nc3ccc(cc3)C(C)C)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1C	InChI=1S/C29H39N3O2/c1-18(2)21-8-10-23(11-9-21)30-28-31-25-14-22(15-27(33)34-7)20(4)13-26(25)32(28)24-12-19(3)16-29(5,6)17-24/h8-11,13-14,18-19,24H,12,15-17H2,1-7H3,(H,30,31)	OEBMFJAGOITKJR-UHFFFAOYSA-N	390582	US9957235, 2-206-1::US9957235, 2-206-2::US9957235, 2-206::US10442772, Example 2-206-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390582&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318670	404959092							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780597	COC(=O)Cc1cc2nc(Nc3ccc(cc3)C(C)C)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1C	InChI=1S/C29H39N3O2/c1-18(2)21-8-10-23(11-9-21)30-28-31-25-14-22(15-27(33)34-7)20(4)13-26(25)32(28)24-12-19(3)16-29(5,6)17-24/h8-11,13-14,18-19,24H,12,15-17H2,1-7H3,(H,30,31)	OEBMFJAGOITKJR-UHFFFAOYSA-N	390582	US9957235, 2-206-1::US9957235, 2-206-2::US9957235, 2-206::US10442772, Example 2-206-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 130							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390582&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318670	404959092							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780598	COC(=O)Cc1cc2nc(Nc3ccc(cc3)C(C)C)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1C	InChI=1S/C29H39N3O2/c1-18(2)21-8-10-23(11-9-21)30-28-31-25-14-22(15-27(33)34-7)20(4)13-26(25)32(28)24-12-19(3)16-29(5,6)17-24/h8-11,13-14,18-19,24H,12,15-17H2,1-7H3,(H,30,31)	OEBMFJAGOITKJR-UHFFFAOYSA-N	390582	US9957235, 2-206-1::US9957235, 2-206-2::US9957235, 2-206::US10442772, Example 2-206-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 50.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390582	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390582&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318670	404959092							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780599	COC(=O)Cc1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1C	InChI=1S/C27H32F3N3O3/c1-16-10-20(15-26(3,4)14-16)33-23-11-17(2)18(13-24(34)35-5)12-22(23)32-25(33)31-19-6-8-21(9-7-19)36-27(28,29)30/h6-9,11-12,16,20H,10,13-15H2,1-5H3,(H,31,32)	BDSGLPYOGVRGRI-UHFFFAOYSA-N	390585	US9957235, 2-207	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390585	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390585&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318671	404959093							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780600	COC(=O)CCc1ccc2n(C3CCCC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C26H30F3N3O3/c1-25(2)14-4-5-19(16-25)32-22-12-6-17(7-13-23(33)34-3)15-21(22)31-24(32)30-18-8-10-20(11-9-18)35-26(27,28)29/h6,8-12,15,19H,4-5,7,13-14,16H2,1-3H3,(H,30,31)	ULQJRNGSLBLTKL-UHFFFAOYSA-N	390586	US9957235, 2-208-1::US9957235, 2-208-2::US9957235, 2-208	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1700							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390586&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123857369	404959094							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780601	COC(=O)CCc1ccc2n(C3CCCC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C26H30F3N3O3/c1-25(2)14-4-5-19(16-25)32-22-12-6-17(7-13-23(33)34-3)15-21(22)31-24(32)30-18-8-10-20(11-9-18)35-26(27,28)29/h6,8-12,15,19H,4-5,7,13-14,16H2,1-3H3,(H,30,31)	ULQJRNGSLBLTKL-UHFFFAOYSA-N	390586	US9957235, 2-208-1::US9957235, 2-208-2::US9957235, 2-208	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 3500							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390586&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123857369	404959094							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780602	COC(=O)CCc1ccc2n(C3CCCC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1	InChI=1S/C26H30F3N3O3/c1-25(2)14-4-5-19(16-25)32-22-12-6-17(7-13-23(33)34-3)15-21(22)31-24(32)30-18-8-10-20(11-9-18)35-26(27,28)29/h6,8-12,15,19H,4-5,7,13-14,16H2,1-3H3,(H,30,31)	ULQJRNGSLBLTKL-UHFFFAOYSA-N	390586	US9957235, 2-208-1::US9957235, 2-208-2::US9957235, 2-208	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 700							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390586	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390586&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123857369	404959094							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780603	COC(=O)CCc1ccc2n(C3CCCC(C)(C)C3)c(Nc3ccc(OC(C)C)cc3)nc2c1	InChI=1S/C28H37N3O3/c1-19(2)34-23-12-10-21(11-13-23)29-27-30-24-17-20(9-15-26(32)33-5)8-14-25(24)31(27)22-7-6-16-28(3,4)18-22/h8,10-14,17,19,22H,6-7,9,15-16,18H2,1-5H3,(H,29,30)	OZOYLBFHCBCICQ-UHFFFAOYSA-N	390589	US9957235, 2-209-2::US9957235, 2-209-1::US9957235, 2-209	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1900							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390589&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123791208	404959095							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780604	COC(=O)CCc1ccc2n(C3CCCC(C)(C)C3)c(Nc3ccc(OC(C)C)cc3)nc2c1	InChI=1S/C28H37N3O3/c1-19(2)34-23-12-10-21(11-13-23)29-27-30-24-17-20(9-15-26(32)33-5)8-14-25(24)31(27)22-7-6-16-28(3,4)18-22/h8,10-14,17,19,22H,6-7,9,15-16,18H2,1-5H3,(H,29,30)	OZOYLBFHCBCICQ-UHFFFAOYSA-N	390589	US9957235, 2-209-2::US9957235, 2-209-1::US9957235, 2-209	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 7000							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390589&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123791208	404959095							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780605	COC(=O)CCc1ccc2n(C3CCCC(C)(C)C3)c(Nc3ccc(OC(C)C)cc3)nc2c1	InChI=1S/C28H37N3O3/c1-19(2)34-23-12-10-21(11-13-23)29-27-30-24-17-20(9-15-26(32)33-5)8-14-25(24)31(27)22-7-6-16-28(3,4)18-22/h8,10-14,17,19,22H,6-7,9,15-16,18H2,1-5H3,(H,29,30)	OZOYLBFHCBCICQ-UHFFFAOYSA-N	390589	US9957235, 2-209-2::US9957235, 2-209-1::US9957235, 2-209	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1500							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390589	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390589&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123791208	404959095							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780606	COC(=O)CCc1ccc2n(C3CCCC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C28H37N3O2/c1-19(2)21-10-12-22(13-11-21)29-27-30-24-17-20(9-15-26(32)33-5)8-14-25(24)31(27)23-7-6-16-28(3,4)18-23/h8,10-14,17,19,23H,6-7,9,15-16,18H2,1-5H3,(H,29,30)	IDBLVYBAQOIALZ-UHFFFAOYSA-N	390592	US9957235, 2-210-2::US9957235, 2-210-1::US9957235, 2-210	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 900							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390592&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123702043	404959096							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780607	COC(=O)CCc1ccc2n(C3CCCC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C28H37N3O2/c1-19(2)21-10-12-22(13-11-21)29-27-30-24-17-20(9-15-26(32)33-5)8-14-25(24)31(27)23-7-6-16-28(3,4)18-23/h8,10-14,17,19,23H,6-7,9,15-16,18H2,1-5H3,(H,29,30)	IDBLVYBAQOIALZ-UHFFFAOYSA-N	390592	US9957235, 2-210-2::US9957235, 2-210-1::US9957235, 2-210	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10000							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390592&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123702043	404959096							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780608	COC(=O)CCc1ccc2n(C3CCCC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C28H37N3O2/c1-19(2)21-10-12-22(13-11-21)29-27-30-24-17-20(9-15-26(32)33-5)8-14-25(24)31(27)23-7-6-16-28(3,4)18-23/h8,10-14,17,19,23H,6-7,9,15-16,18H2,1-5H3,(H,29,30)	IDBLVYBAQOIALZ-UHFFFAOYSA-N	390592	US9957235, 2-210-2::US9957235, 2-210-1::US9957235, 2-210	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 490							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390592&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			123702043	404959096							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780609	COC(=O)CCc1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(C)C)cc3)nc2c1	InChI=1S/C30H41N3O3/c1-20(2)36-24-12-10-22(11-13-24)31-28-32-25-16-21(9-15-27(34)35-7)8-14-26(25)33(28)23-17-29(3,4)19-30(5,6)18-23/h8,10-14,16,20,23H,9,15,17-19H2,1-7H3,(H,31,32)	UQCZBXNILOJKGW-UHFFFAOYSA-N	390595	US9957235, 2-211::US10442772, Example 2-211	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 430							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390595&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318676	404959097							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780610	COC(=O)CCc1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C30H41N3O2/c1-20(2)22-10-12-23(13-11-22)31-28-32-25-16-21(9-15-27(34)35-7)8-14-26(25)33(28)24-17-29(3,4)19-30(5,6)18-24/h8,10-14,16,20,24H,9,15,17-19H2,1-7H3,(H,31,32)	LEKNCWJPRLHBQU-UHFFFAOYSA-N	390596	US9957235, 2-212::US10442772, Example 2-212	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 90.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390596&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319013	404959098							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780611	COC(=O)Cc1cc2nc(Nc3ccc(cc3)C(C)C)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1O	InChI=1S/C28H37N3O3/c1-17(2)19-7-9-21(10-8-19)29-27-30-23-12-20(13-26(33)34-6)25(32)14-24(23)31(27)22-11-18(3)15-28(4,5)16-22/h7-10,12,14,17-18,22,32H,11,13,15-16H2,1-6H3,(H,29,30)	QVKNCQSYSZYOGF-UHFFFAOYSA-N	390597	US9957235, 2-213-1::US9957235, 2-213-2::US9957235, 2-213	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390597&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011693	404959099							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780612	COC(=O)Cc1cc2nc(Nc3ccc(cc3)C(C)C)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1O	InChI=1S/C28H37N3O3/c1-17(2)19-7-9-21(10-8-19)29-27-30-23-12-20(13-26(33)34-6)25(32)14-24(23)31(27)22-11-18(3)15-28(4,5)16-22/h7-10,12,14,17-18,22,32H,11,13,15-16H2,1-6H3,(H,29,30)	QVKNCQSYSZYOGF-UHFFFAOYSA-N	390597	US9957235, 2-213-1::US9957235, 2-213-2::US9957235, 2-213	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 60.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390597&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011693	404959099							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780613	COC(=O)Cc1cc2nc(Nc3ccc(cc3)C(C)C)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1O	InChI=1S/C28H37N3O3/c1-17(2)19-7-9-21(10-8-19)29-27-30-23-12-20(13-26(33)34-6)25(32)14-24(23)31(27)22-11-18(3)15-28(4,5)16-22/h7-10,12,14,17-18,22,32H,11,13,15-16H2,1-6H3,(H,29,30)	QVKNCQSYSZYOGF-UHFFFAOYSA-N	390597	US9957235, 2-213-1::US9957235, 2-213-2::US9957235, 2-213	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390597&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011693	404959099							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780614	COC(=O)Cc1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C29H39N3O4/c1-18(2)36-23-10-8-21(9-11-23)30-28-31-24-13-20(14-27(33)35-7)26(34-6)15-25(24)32(28)22-12-19(3)16-29(4,5)17-22/h8-11,13,15,18-19,22H,12,14,16-17H2,1-7H3,(H,30,31)	YAEMHBZMWQMZLB-UHFFFAOYSA-N	390600	US9957235, 2-214-2::US9957235, 2-214-1::US9957235, 2-214::US10442772, Example 2-214-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 120							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390600&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318632	404959100							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780615	COC(=O)Cc1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C29H39N3O4/c1-18(2)36-23-10-8-21(9-11-23)30-28-31-24-13-20(14-27(33)35-7)26(34-6)15-25(24)32(28)22-12-19(3)16-29(4,5)17-22/h8-11,13,15,18-19,22H,12,14,16-17H2,1-7H3,(H,30,31)	YAEMHBZMWQMZLB-UHFFFAOYSA-N	390600	US9957235, 2-214-2::US9957235, 2-214-1::US9957235, 2-214::US10442772, Example 2-214-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 400							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390600&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318632	404959100							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780616	COC(=O)Cc1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C29H39N3O4/c1-18(2)36-23-10-8-21(9-11-23)30-28-31-24-13-20(14-27(33)35-7)26(34-6)15-25(24)32(28)22-12-19(3)16-29(4,5)17-22/h8-11,13,15,18-19,22H,12,14,16-17H2,1-7H3,(H,30,31)	YAEMHBZMWQMZLB-UHFFFAOYSA-N	390600	US9957235, 2-214-2::US9957235, 2-214-1::US9957235, 2-214::US10442772, Example 2-214-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390600&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318632	404959100							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780617	COC(=O)Cc1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C27H32F3N3O4/c1-16-10-19(15-26(2,3)14-16)33-22-13-23(35-4)17(12-24(34)36-5)11-21(22)32-25(33)31-18-6-8-20(9-7-18)37-27(28,29)30/h6-9,11,13,16,19H,10,12,14-15H2,1-5H3,(H,31,32)	DALHBJCSQMZXRI-UHFFFAOYSA-N	390603	US9957235, 2-215-1::US9957235, 2-215-2::US9957235, 2-215::US10442772, Example 2-215-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390603&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318981	404959101							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780618	COC(=O)Cc1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C27H32F3N3O4/c1-16-10-19(15-26(2,3)14-16)33-22-13-23(35-4)17(12-24(34)36-5)11-21(22)32-25(33)31-18-6-8-20(9-7-18)37-27(28,29)30/h6-9,11,13,16,19H,10,12,14-15H2,1-5H3,(H,31,32)	DALHBJCSQMZXRI-UHFFFAOYSA-N	390603	US9957235, 2-215-1::US9957235, 2-215-2::US9957235, 2-215::US10442772, Example 2-215-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 180							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390603&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318981	404959101							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780619	COC(=O)Cc1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1OC	InChI=1S/C27H32F3N3O4/c1-16-10-19(15-26(2,3)14-16)33-22-13-23(35-4)17(12-24(34)36-5)11-21(22)32-25(33)31-18-6-8-20(9-7-18)37-27(28,29)30/h6-9,11,13,16,19H,10,12,14-15H2,1-5H3,(H,31,32)	DALHBJCSQMZXRI-UHFFFAOYSA-N	390603	US9957235, 2-215-1::US9957235, 2-215-2::US9957235, 2-215::US10442772, Example 2-215-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390603&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318981	404959101							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780620	COC(=O)Cc1cc2nc(Nc3ccc(cc3)C(C)C)n(C3CC(C)(C)CC(C)(C)C3)c2cc1F	InChI=1S/C29H38FN3O2/c1-18(2)19-8-10-21(11-9-19)31-27-32-24-12-20(13-26(34)35-7)23(30)14-25(24)33(27)22-15-28(3,4)17-29(5,6)16-22/h8-12,14,18,22H,13,15-17H2,1-7H3,(H,31,32)	XDSTUALZHFHDPA-UHFFFAOYSA-N	390606	US9957235, 2-216::US10442772, Example 2-216	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 250							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390606&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318829	404959102							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780621	COC(=O)Cc1cc2nc(Nc3ccc(OC(C)C)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2cc1F	InChI=1S/C29H38FN3O3/c1-18(2)36-22-10-8-20(9-11-22)31-27-32-24-12-19(13-26(34)35-7)23(30)14-25(24)33(27)21-15-28(3,4)17-29(5,6)16-21/h8-12,14,18,21H,13,15-17H2,1-7H3,(H,31,32)	FLJUUUOXSFLLHK-UHFFFAOYSA-N	390607	US9957235, 2-217::US10442772, Example 2-217	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 500							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390607&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318830	404959103							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780622	COC(=O)Cc1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2cc1F	InChI=1S/C27H31F4N3O3/c1-25(2)13-18(14-26(3,4)15-25)34-22-12-20(28)16(11-23(35)36-5)10-21(22)33-24(34)32-17-6-8-19(9-7-17)37-27(29,30)31/h6-10,12,18H,11,13-15H2,1-5H3,(H,32,33)	LXIWOZRUCIHQBS-UHFFFAOYSA-N	390608	US9957235, 2-218::US10442772, Example 2-218	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 600							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390608&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318831	404959104							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780623	COC(=O)Cc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C28H37N3O2/c1-18(2)21-8-10-22(11-9-21)29-27-30-24-14-20(15-26(32)33-6)7-12-25(24)31(27)23-13-19(3)16-28(4,5)17-23/h7-12,14,18-19,23H,13,15-17H2,1-6H3,(H,29,30)	BWQVSPBOCNDZFI-UHFFFAOYSA-N	390566	US9957235, 2-219::US9957235, 2-198-2::US9957235, 2-198-1::US9957235, 2-219-1::US9957235, 2-219-2::US9957235, 2-198::US10442772, Example 2-198-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 240							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390566&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319035	404959084							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780624	COC(=O)Cc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C28H37N3O2/c1-18(2)21-8-10-22(11-9-21)29-27-30-24-14-20(15-26(32)33-6)7-12-25(24)31(27)23-13-19(3)16-28(4,5)17-23/h7-12,14,18-19,23H,13,15-17H2,1-6H3,(H,29,30)	BWQVSPBOCNDZFI-UHFFFAOYSA-N	390566	US9957235, 2-219::US9957235, 2-198-2::US9957235, 2-198-1::US9957235, 2-219-1::US9957235, 2-219-2::US9957235, 2-198::US10442772, Example 2-198-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1400							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390566&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319035	404959084							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780625	COC(=O)Cc1ccc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2c1	InChI=1S/C28H37N3O2/c1-18(2)21-8-10-22(11-9-21)29-27-30-24-14-20(15-26(32)33-6)7-12-25(24)31(27)23-13-19(3)16-28(4,5)17-23/h7-12,14,18-19,23H,13,15-17H2,1-6H3,(H,29,30)	BWQVSPBOCNDZFI-UHFFFAOYSA-N	390566	US9957235, 2-219::US9957235, 2-198-2::US9957235, 2-198-1::US9957235, 2-219-1::US9957235, 2-219-2::US9957235, 2-198::US10442772, Example 2-198-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 220							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390566&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319035	404959084							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780626	COC(=O)Cc1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1F	InChI=1S/C28H36FN3O3/c1-17(2)35-22-9-7-20(8-10-22)30-27-31-24-12-19(13-26(33)34-6)23(29)14-25(24)32(27)21-11-18(3)15-28(4,5)16-21/h7-10,12,14,17-18,21H,11,13,15-16H2,1-6H3,(H,30,31)	KNPNCAKZDGVODS-UHFFFAOYSA-N	390612	US9957235, 2-220::US10442772, Example 2-220-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1700							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390612&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318832	404959105							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780627	COC(=O)Cc1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1F	InChI=1S/C26H29F4N3O3/c1-15-9-18(14-25(2,3)13-15)33-22-12-20(27)16(11-23(34)35-4)10-21(22)32-24(33)31-17-5-7-19(8-6-17)36-26(28,29)30/h5-8,10,12,15,18H,9,11,13-14H2,1-4H3,(H,31,32)	YCRCCGFXJUAYKG-UHFFFAOYSA-N	390613	US9957235, 2-220-2::US9957235, 2-220-1::US10442772, Example 2-221-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2600							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390613&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319030	404959106							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780628	COC(=O)Cc1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@H]3C[C@@H](C)CC(C)(C)C3)c2cc1F	InChI=1S/C26H29F4N3O3/c1-15-9-18(14-25(2,3)13-15)33-22-12-20(27)16(11-23(34)35-4)10-21(22)32-24(33)31-17-5-7-19(8-6-17)36-26(28,29)30/h5-8,10,12,15,18H,9,11,13-14H2,1-4H3,(H,31,32)	YCRCCGFXJUAYKG-UHFFFAOYSA-N	390613	US9957235, 2-220-2::US9957235, 2-220-1::US10442772, Example 2-221-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 700							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390613&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319030	404959106							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780629	COC(=O)Cc1cc2nc(Nc3ccc(cc3)C(C)C)n(C3CC(C)(C)CC(C)(C)C3)c2cc1OC	InChI=1S/C30H41N3O3/c1-19(2)20-9-11-22(12-10-20)31-28-32-24-13-21(14-27(34)36-8)26(35-7)15-25(24)33(28)23-16-29(3,4)18-30(5,6)17-23/h9-13,15,19,23H,14,16-18H2,1-8H3,(H,31,32)	KEPGPXJBFLEWAB-UHFFFAOYSA-N	390615	US9957235, 2-221-2::US9957235, 2-221-1::US9957235, 2-222::US9957235, 2-221::US10442772, Example 2-222	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 850							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390615&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319020	404959107							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780630	COC(=O)Cc1cc2nc(Nc3ccc(cc3)C(C)C)n(C3CC(C)(C)CC(C)(C)C3)c2cc1OC	InChI=1S/C30H41N3O3/c1-19(2)20-9-11-22(12-10-20)31-28-32-24-13-21(14-27(34)36-8)26(35-7)15-25(24)33(28)23-16-29(3,4)18-30(5,6)17-23/h9-13,15,19,23H,14,16-18H2,1-8H3,(H,31,32)	KEPGPXJBFLEWAB-UHFFFAOYSA-N	390615	US9957235, 2-221-2::US9957235, 2-221-1::US9957235, 2-222::US9957235, 2-221::US10442772, Example 2-222	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1900							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390615&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319020	404959107							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780631	COC(=O)Cc1cc2nc(Nc3ccc(cc3)C(C)C)n(C3CC(C)(C)CC(C)(C)C3)c2cc1OC	InChI=1S/C30H41N3O3/c1-19(2)20-9-11-22(12-10-20)31-28-32-24-13-21(14-27(34)36-8)26(35-7)15-25(24)33(28)23-16-29(3,4)18-30(5,6)17-23/h9-13,15,19,23H,14,16-18H2,1-8H3,(H,31,32)	KEPGPXJBFLEWAB-UHFFFAOYSA-N	390615	US9957235, 2-221-2::US9957235, 2-221-1::US9957235, 2-222::US9957235, 2-221::US10442772, Example 2-222	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 730							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390615&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319020	404959107							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780632	COC(=O)Cc1cc2nc(Nc3ccc(cc3)C(C)C)n(C3CC(C)(C)CC(C)(C)C3)c2cc1OC	InChI=1S/C30H41N3O3/c1-19(2)20-9-11-22(12-10-20)31-28-32-24-13-21(14-27(34)36-8)26(35-7)15-25(24)33(28)23-16-29(3,4)18-30(5,6)17-23/h9-13,15,19,23H,14,16-18H2,1-8H3,(H,31,32)	KEPGPXJBFLEWAB-UHFFFAOYSA-N	390615	US9957235, 2-221-2::US9957235, 2-221-1::US9957235, 2-222::US9957235, 2-221::US10442772, Example 2-222	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390615&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319020	404959107							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780633	COC(=O)Cc1cc2nc(Nc3ccc(OC(C)C)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2cc1OC	InChI=1S/C30H41N3O4/c1-19(2)37-23-11-9-21(10-12-23)31-28-32-24-13-20(14-27(34)36-8)26(35-7)15-25(24)33(28)22-16-29(3,4)18-30(5,6)17-22/h9-13,15,19,22H,14,16-18H2,1-8H3,(H,31,32)	RUTWWARRNQDGRD-UHFFFAOYSA-N	390619	US9957235, 2-223::US10442772, Example 2-223	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390619&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319021	404959108							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780634	COC(=O)Cc1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n(C3CC(C)(C)CC(C)(C)C3)c2cc1OC	InChI=1S/C28H34F3N3O4/c1-26(2)14-19(15-27(3,4)16-26)34-22-13-23(36-5)17(12-24(35)37-6)11-21(22)33-25(34)32-18-7-9-20(10-8-18)38-28(29,30)31/h7-11,13,19H,12,14-16H2,1-6H3,(H,32,33)	DKEKDTVLMVOICL-UHFFFAOYSA-N	390620	US9957235, 2-224::US10442772, Example 2-224	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390620&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319023	404959109							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780635	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CC(O)=O)ccc12 |r|	InChI=1S/C25H28F3N3O3/c1-15-10-18(14-24(2,3)13-15)31-21-9-4-16(12-22(32)33)11-20(21)30-23(31)29-17-5-7-19(8-6-17)34-25(26,27)28/h4-9,11,15,18H,10,12-14H2,1-3H3,(H,29,30)(H,32,33)	RMFIERQLLAPUDQ-UHFFFAOYSA-N	390621	US9957235, 2-225::US10442772, Example 2-225-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390621&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310381	404959110							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780636	C[C@@H]1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CC(O)=O)ccc12 |r|	InChI=1S/C25H28F3N3O3/c1-15-10-18(14-24(2,3)13-15)31-21-9-4-16(12-22(32)33)11-20(21)30-23(31)29-17-5-7-19(8-6-17)34-25(26,27)28/h4-9,11,15,18H,10,12-14H2,1-3H3,(H,29,30)(H,32,33)	RMFIERQLLAPUDQ-UHFFFAOYSA-N	390622	US9957235, 2-225-2::US9957235, 2-225-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 600							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390622&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011694	404959111							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780637	C[C@@H]1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CC(O)=O)ccc12 |r|	InChI=1S/C25H28F3N3O3/c1-15-10-18(14-24(2,3)13-15)31-21-9-4-16(12-22(32)33)11-20(21)30-23(31)29-17-5-7-19(8-6-17)34-25(26,27)28/h4-9,11,15,18H,10,12-14H2,1-3H3,(H,29,30)(H,32,33)	RMFIERQLLAPUDQ-UHFFFAOYSA-N	390622	US9957235, 2-225-2::US9957235, 2-225-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 50.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390622&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011694	404959111							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780638	CC(C)Oc1ccc(Nc2nc3cc(CC(O)=O)ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C27H35N3O3/c1-17(2)33-22-9-7-20(8-10-22)28-26-29-23-13-19(14-25(31)32)6-11-24(23)30(26)21-12-18(3)15-27(4,5)16-21/h6-11,13,17-18,21H,12,14-16H2,1-5H3,(H,28,29)(H,31,32)	PWIWVXULADEBKS-UHFFFAOYSA-N	390624	US9957235, 2-226::US10442772, Example 2-226-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 130							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390624&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310508	404959112							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780639	CC(F)Oc1ccc(Nc2nc3cc(CC(O)=O)ccc3n2C2C[C@@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C26H32FN3O3/c1-16-11-20(15-26(3,4)14-16)30-23-10-5-18(13-24(31)32)12-22(23)29-25(30)28-19-6-8-21(9-7-19)33-17(2)27/h5-10,12,16-17,20H,11,13-15H2,1-4H3,(H,28,29)(H,31,32)	KGSKZFFWDWHNGN-UHFFFAOYSA-N	390625	US9957235, 2-226-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1200							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390625&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011695	404959113							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780640	CC(C)Oc1ccc(Nc2nc3cc(CC(O)=O)ccc3n2C2C[C@@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C27H35N3O3/c1-17(2)33-22-9-7-20(8-10-22)28-26-29-23-13-19(14-25(31)32)6-11-24(23)30(26)21-12-18(3)15-27(4,5)16-21/h6-11,13,17-18,21H,12,14-16H2,1-5H3,(H,28,29)(H,31,32)	PWIWVXULADEBKS-UHFFFAOYSA-N	390626	US9957235, 2-231-1::US9957235, 2-226-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 220							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390626&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011696	404959114							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780641	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CC(O)=O)ccc12	InChI=1S/C26H30F3N3O3/c1-24(2)13-18(14-25(3,4)15-24)32-21-10-5-16(12-22(33)34)11-20(21)31-23(32)30-17-6-8-19(9-7-17)35-26(27,28)29/h5-11,18H,12-15H2,1-4H3,(H,30,31)(H,33,34)	AVEAWLCFPSGRQD-UHFFFAOYSA-N	390627	US9957235, 2-227::US10442772, Example 2-227	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390627&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318636	404959115							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780642	CC(C)Oc1ccc(Nc2nc3cc(CC(O)=O)ccc3n2C2CC(C)(C)CC(C)(C)C2)cc1	InChI=1S/C28H37N3O3/c1-18(2)34-22-10-8-20(9-11-22)29-26-30-23-13-19(14-25(32)33)7-12-24(23)31(26)21-15-27(3,4)17-28(5,6)16-21/h7-13,18,21H,14-17H2,1-6H3,(H,29,30)(H,32,33)	KYYZDJFEWZGSAN-UHFFFAOYSA-N	390628	US9957235, 2-228::US10442772, Example 2-228	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390628&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318635	404959116							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780643	CC(C)c1ccc(Nc2nc3cc(CC(O)=O)ccc3n2C2CC(C)(C)CC(C)(C)C2)cc1	InChI=1S/C28H37N3O2/c1-18(2)20-8-10-21(11-9-20)29-26-30-23-13-19(14-25(32)33)7-12-24(23)31(26)22-15-27(3,4)17-28(5,6)16-22/h7-13,18,22H,14-17H2,1-6H3,(H,29,30)(H,32,33)	GFMCQUKGINIVSW-UHFFFAOYSA-N	390629	US9957235, 2-229::US10442772, Example 2-229	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390629&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318711	404959117							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780644	CC1(C)CCC[C@H](C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(O)=O)ccc12 |r|	InChI=1S/C25H28F3N3O3/c1-24(2)13-3-4-18(15-24)31-21-11-5-16(6-12-22(32)33)14-20(21)30-23(31)29-17-7-9-19(10-8-17)34-25(26,27)28/h5,7-11,14,18H,3-4,6,12-13,15H2,1-2H3,(H,29,30)(H,32,33)	MDIKLUQTOPSIDZ-UHFFFAOYSA-N	390630	US9957235, 2-230::US10442772, Example 2-230-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 60.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390630&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310558	404959118							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780645	CC1(C)CCCC(C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(O)=C)ccc12	InChI=1S/C26H30F3N3O2/c1-17(33)6-7-18-8-13-23-22(15-18)31-24(32(23)20-5-4-14-25(2,3)16-20)30-19-9-11-21(12-10-19)34-26(27,28)29/h8-13,15,20,33H,1,4-7,14,16H2,2-3H3,(H,30,31)	UGGQGANKKNSMRN-UHFFFAOYSA-N	390631	US9957235, 2-231-2::US9957235, 2-230-2::US9957235, 2-230-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 580							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390631&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011697	404959119							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780646	CC1(C)CCCC(C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(O)=C)ccc12	InChI=1S/C26H30F3N3O2/c1-17(33)6-7-18-8-13-23-22(15-18)31-24(32(23)20-5-4-14-25(2,3)16-20)30-19-9-11-21(12-10-19)34-26(27,28)29/h8-13,15,20,33H,1,4-7,14,16H2,2-3H3,(H,30,31)	UGGQGANKKNSMRN-UHFFFAOYSA-N	390631	US9957235, 2-231-2::US9957235, 2-230-2::US9957235, 2-230-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390631&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011697	404959119							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780647	CC(C)c1ccc(Nc2nc3cc(CC(O)=O)ccc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C27H35N3O2/c1-17(2)20-7-9-21(10-8-20)28-26-29-23-13-19(14-25(31)32)6-11-24(23)30(26)22-12-18(3)15-27(4,5)16-22/h6-11,13,17-18,22H,12,14-16H2,1-5H3,(H,28,29)(H,31,32)	RBDPRDBWQJOHTD-UHFFFAOYSA-N	390633	US9957235, 2-231::US10442772, Example 2-231-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390633&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310529	404959120							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780648	CC(C)Oc1ccc(Nc2nc3cc(CC(O)=O)ccc3n2C2C[C@@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C27H35N3O3/c1-17(2)33-22-9-7-20(8-10-22)28-26-29-23-13-19(14-25(31)32)6-11-24(23)30(26)21-12-18(3)15-27(4,5)16-21/h6-11,13,17-18,21H,12,14-16H2,1-5H3,(H,28,29)(H,31,32)	PWIWVXULADEBKS-UHFFFAOYSA-N	390626	US9957235, 2-231-1::US9957235, 2-226-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 190							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390626&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011696	404959114							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780649	CC1(C)CCCC(C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(O)=C)ccc12	InChI=1S/C26H30F3N3O2/c1-17(33)6-7-18-8-13-23-22(15-18)31-24(32(23)20-5-4-14-25(2,3)16-20)30-19-9-11-21(12-10-19)34-26(27,28)29/h8-13,15,20,33H,1,4-7,14,16H2,2-3H3,(H,30,31)	UGGQGANKKNSMRN-UHFFFAOYSA-N	390631	US9957235, 2-231-2::US9957235, 2-230-2::US9957235, 2-230-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390631&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011697	404959119							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780650	CC(C)c1ccc(Nc2nc3cc(CCC(O)=O)ccc3n2C2CC(C)(C)CC(C)(C)C2)cc1	InChI=1S/C29H39N3O2/c1-19(2)21-9-11-22(12-10-21)30-27-31-24-15-20(8-14-26(33)34)7-13-25(24)32(27)23-16-28(3,4)18-29(5,6)17-23/h7,9-13,15,19,23H,8,14,16-18H2,1-6H3,(H,30,31)(H,33,34)	IBEUHHFLADTBKZ-UHFFFAOYSA-N	390636	US9957235, 2-232::US10442772, Example 2-232	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390636&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310622	404959121							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780651	CC(C)c1ccc(Nc2nc3cc(CCC(O)=O)ccc3n2[C@@H]2CCCC(C)(C)C2)cc1 |r|	InChI=1S/C27H35N3O2/c1-18(2)20-9-11-21(12-10-20)28-26-29-23-16-19(8-14-25(31)32)7-13-24(23)30(26)22-6-5-15-27(3,4)17-22/h7,9-13,16,18,22H,5-6,8,14-15,17H2,1-4H3,(H,28,29)(H,31,32)	VAHHCMLOSSLRAR-UHFFFAOYSA-N	390637	US9957235, 2-233-1::US9957235, 2-233-2::US9957235, 2-233::US10442772, Example 2-233-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 50.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390637&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310555	404959122							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780652	CC(C)c1ccc(Nc2nc3cc(CCC(O)=O)ccc3n2[C@@H]2CCCC(C)(C)C2)cc1 |r|	InChI=1S/C27H35N3O2/c1-18(2)20-9-11-21(12-10-20)28-26-29-23-16-19(8-14-25(31)32)7-13-24(23)30(26)22-6-5-15-27(3,4)17-22/h7,9-13,16,18,22H,5-6,8,14-15,17H2,1-4H3,(H,28,29)(H,31,32)	VAHHCMLOSSLRAR-UHFFFAOYSA-N	390637	US9957235, 2-233-1::US9957235, 2-233-2::US9957235, 2-233::US10442772, Example 2-233-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 630							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390637&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310555	404959122							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780653	CC(C)c1ccc(Nc2nc3cc(CCC(O)=O)ccc3n2[C@@H]2CCCC(C)(C)C2)cc1 |r|	InChI=1S/C27H35N3O2/c1-18(2)20-9-11-21(12-10-20)28-26-29-23-16-19(8-14-25(31)32)7-13-24(23)30(26)22-6-5-15-27(3,4)17-22/h7,9-13,16,18,22H,5-6,8,14-15,17H2,1-4H3,(H,28,29)(H,31,32)	VAHHCMLOSSLRAR-UHFFFAOYSA-N	390637	US9957235, 2-233-1::US9957235, 2-233-2::US9957235, 2-233::US10442772, Example 2-233-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390637&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310555	404959122							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780654	CC(C)Oc1ccc(Nc2nc3cc(CCC(O)=O)ccc3n2[C@@H]2CCCC(C)(C)C2)cc1 |r|	InChI=1S/C27H35N3O3/c1-18(2)33-22-11-9-20(10-12-22)28-26-29-23-16-19(8-14-25(31)32)7-13-24(23)30(26)21-6-5-15-27(3,4)17-21/h7,9-13,16,18,21H,5-6,8,14-15,17H2,1-4H3,(H,28,29)(H,31,32)	PHBJIBVCOYVKKV-UHFFFAOYSA-N	390640	US9957235, 2-234-1::US9957235, 2-234-2::US9957235, 2-234::US10442772, Example 2-234-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 300							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390640&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310654	404959123							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780655	CC(C)Oc1ccc(Nc2nc3cc(CCC(O)=O)ccc3n2[C@@H]2CCCC(C)(C)C2)cc1 |r|	InChI=1S/C27H35N3O3/c1-18(2)33-22-11-9-20(10-12-22)28-26-29-23-16-19(8-14-25(31)32)7-13-24(23)30(26)21-6-5-15-27(3,4)17-21/h7,9-13,16,18,21H,5-6,8,14-15,17H2,1-4H3,(H,28,29)(H,31,32)	PHBJIBVCOYVKKV-UHFFFAOYSA-N	390640	US9957235, 2-234-1::US9957235, 2-234-2::US9957235, 2-234::US10442772, Example 2-234-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 3300							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390640&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310654	404959123							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780656	CC(C)Oc1ccc(Nc2nc3cc(CCC(O)=O)ccc3n2[C@@H]2CCCC(C)(C)C2)cc1 |r|	InChI=1S/C27H35N3O3/c1-18(2)33-22-11-9-20(10-12-22)28-26-29-23-16-19(8-14-25(31)32)7-13-24(23)30(26)21-6-5-15-27(3,4)17-21/h7,9-13,16,18,21H,5-6,8,14-15,17H2,1-4H3,(H,28,29)(H,31,32)	PHBJIBVCOYVKKV-UHFFFAOYSA-N	390640	US9957235, 2-234-1::US9957235, 2-234-2::US9957235, 2-234::US10442772, Example 2-234-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 350							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390640&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310654	404959123							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780657	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(O)=O)ccc12	InChI=1S/C27H32F3N3O3/c1-25(2)14-19(15-26(3,4)16-25)33-22-11-5-17(6-12-23(34)35)13-21(22)32-24(33)31-18-7-9-20(10-8-18)36-27(28,29)30/h5,7-11,13,19H,6,12,14-16H2,1-4H3,(H,31,32)(H,34,35)	KKWAQTUVJHAPJY-UHFFFAOYSA-N	390643	US9957235, 2-235::US10442772, Example 2-235	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390643&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310562	404959124							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780658	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CC(O)=O)c(C)cc12 |r|	InChI=1S/C26H30F3N3O3/c1-15-9-19(14-25(3,4)13-15)32-22-10-16(2)17(12-23(33)34)11-21(22)31-24(32)30-18-5-7-20(8-6-18)35-26(27,28)29/h5-8,10-11,15,19H,9,12-14H2,1-4H3,(H,30,31)(H,33,34)	KUWULFLLHTWYQB-UHFFFAOYSA-N	390644	US9957235, 2-236-1::US9957235, 2-236-2::US9957235, 2-236::US10442772, Example 2-236-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390644&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310639	404959125							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780659	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CC(O)=O)c(C)cc12 |r|	InChI=1S/C26H30F3N3O3/c1-15-9-19(14-25(3,4)13-15)32-22-10-16(2)17(12-23(33)34)11-21(22)31-24(32)30-18-5-7-20(8-6-18)35-26(27,28)29/h5-8,10-11,15,19H,9,12-14H2,1-4H3,(H,30,31)(H,33,34)	KUWULFLLHTWYQB-UHFFFAOYSA-N	390644	US9957235, 2-236-1::US9957235, 2-236-2::US9957235, 2-236::US10442772, Example 2-236-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 100.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390644&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310639	404959125							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780660	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CC(O)=O)c(C)cc12 |r|	InChI=1S/C26H30F3N3O3/c1-15-9-19(14-25(3,4)13-15)32-22-10-16(2)17(12-23(33)34)11-21(22)31-24(32)30-18-5-7-20(8-6-18)35-26(27,28)29/h5-8,10-11,15,19H,9,12-14H2,1-4H3,(H,30,31)(H,33,34)	KUWULFLLHTWYQB-UHFFFAOYSA-N	390644	US9957235, 2-236-1::US9957235, 2-236-2::US9957235, 2-236::US10442772, Example 2-236-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390644&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310639	404959125							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780661	CC(C)c1ccc(Nc2nc3cc(CC(O)=O)c(C)cc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C28H37N3O2/c1-17(2)20-7-9-22(10-8-20)29-27-30-24-13-21(14-26(32)33)19(4)12-25(24)31(27)23-11-18(3)15-28(5,6)16-23/h7-10,12-13,17-18,23H,11,14-16H2,1-6H3,(H,29,30)(H,32,33)	SVGIEKTYEVCEOB-UHFFFAOYSA-N	390647	US9957235, 2-237-1::US9957235, 2-237-2::US9957235, 2-237::US10442772, Example 2-237-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390647&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310458	404959126							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780662	CC(C)c1ccc(Nc2nc3cc(CC(O)=O)c(C)cc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C28H37N3O2/c1-17(2)20-7-9-22(10-8-20)29-27-30-24-13-21(14-26(32)33)19(4)12-25(24)31(27)23-11-18(3)15-28(5,6)16-23/h7-10,12-13,17-18,23H,11,14-16H2,1-6H3,(H,29,30)(H,32,33)	SVGIEKTYEVCEOB-UHFFFAOYSA-N	390647	US9957235, 2-237-1::US9957235, 2-237-2::US9957235, 2-237::US10442772, Example 2-237-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390647&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310458	404959126							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780663	CC(C)c1ccc(Nc2nc3cc(CC(O)=O)c(C)cc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C28H37N3O2/c1-17(2)20-7-9-22(10-8-20)29-27-30-24-13-21(14-26(32)33)19(4)12-25(24)31(27)23-11-18(3)15-28(5,6)16-23/h7-10,12-13,17-18,23H,11,14-16H2,1-6H3,(H,29,30)(H,32,33)	SVGIEKTYEVCEOB-UHFFFAOYSA-N	390647	US9957235, 2-237-1::US9957235, 2-237-2::US9957235, 2-237::US10442772, Example 2-237-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 9.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390647&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310458	404959126							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780664	CC(C)Oc1ccc(Nc2nc3cc(CC(O)=O)c(C)cc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C28H37N3O3/c1-17(2)34-23-9-7-21(8-10-23)29-27-30-24-13-20(14-26(32)33)19(4)12-25(24)31(27)22-11-18(3)15-28(5,6)16-22/h7-10,12-13,17-18,22H,11,14-16H2,1-6H3,(H,29,30)(H,32,33)	LBPZQTVIJVMPFD-UHFFFAOYSA-N	390650	US9957235, 2-238-1::US9957235, 2-238-2::US9957235, 2-238::US10442772, Example 2-238-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 120							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390650&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310625	404959127							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780665	CC(C)Oc1ccc(Nc2nc3cc(CC(O)=O)c(C)cc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C28H37N3O3/c1-17(2)34-23-9-7-21(8-10-23)29-27-30-24-13-20(14-26(32)33)19(4)12-25(24)31(27)22-11-18(3)15-28(5,6)16-22/h7-10,12-13,17-18,22H,11,14-16H2,1-6H3,(H,29,30)(H,32,33)	LBPZQTVIJVMPFD-UHFFFAOYSA-N	390650	US9957235, 2-238-1::US9957235, 2-238-2::US9957235, 2-238::US10442772, Example 2-238-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 250							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390650&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310625	404959127							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780666	CC(C)Oc1ccc(Nc2nc3cc(CC(O)=O)c(C)cc3n2[C@@H]2C[C@H](C)CC(C)(C)C2)cc1 |r|	InChI=1S/C28H37N3O3/c1-17(2)34-23-9-7-21(8-10-23)29-27-30-24-13-20(14-26(32)33)19(4)12-25(24)31(27)22-11-18(3)15-28(5,6)16-22/h7-10,12-13,17-18,22H,11,14-16H2,1-6H3,(H,29,30)(H,32,33)	LBPZQTVIJVMPFD-UHFFFAOYSA-N	390650	US9957235, 2-238-1::US9957235, 2-238-2::US9957235, 2-238::US10442772, Example 2-238-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 60.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390650&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310625	404959127							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780667	Cc1cc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1CC(O)=O	InChI=1S/C27H32F3N3O3/c1-16-10-22-21(11-17(16)12-23(34)35)32-24(31-18-6-8-20(9-7-18)36-27(28,29)30)33(22)19-13-25(2,3)15-26(4,5)14-19/h6-11,19H,12-15H2,1-5H3,(H,31,32)(H,34,35)	PFKZHKVHJUZXEY-UHFFFAOYSA-N	390653	US9957235, 2-239::US10442772, Example 2-239	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390653	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390653&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310767	404959128							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780668	CC(C)c1ccc(Nc2nc3cc(CC(O)=O)c(C)cc3n2C2CC(C)(C)CC(C)(C)C2)cc1	InChI=1S/C29H39N3O2/c1-18(2)20-8-10-22(11-9-20)30-27-31-24-13-21(14-26(33)34)19(3)12-25(24)32(27)23-15-28(4,5)17-29(6,7)16-23/h8-13,18,23H,14-17H2,1-7H3,(H,30,31)(H,33,34)	OSQZOHAKEDLCQF-UHFFFAOYSA-N	390654	US9957235, 2-240::US10442772, Example 2-240	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390654&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319037	404959129							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780669	CC(C)Oc1ccc(Nc2nc3cc(CC(O)=O)c(C)cc3n2C2CC(C)(C)CC(C)(C)C2)cc1	InChI=1S/C29H39N3O3/c1-18(2)35-23-10-8-21(9-11-23)30-27-31-24-13-20(14-26(33)34)19(3)12-25(24)32(27)22-15-28(4,5)17-29(6,7)16-22/h8-13,18,22H,14-17H2,1-7H3,(H,30,31)(H,33,34)	MAVPXVJCUNQQQN-UHFFFAOYSA-N	390655	US9957235, 2-241::US10442772, Example 2-241	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390655	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390655&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310729	404959130							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780670	CC(C)c1ccc(Nc2nc3cc(CC(O)=O)c(F)cc3n2C2CC(C)(C)CC(C)(C)C2)cc1	InChI=1S/C28H36FN3O2/c1-17(2)18-7-9-20(10-8-18)30-26-31-23-11-19(12-25(33)34)22(29)13-24(23)32(26)21-14-27(3,4)16-28(5,6)15-21/h7-11,13,17,21H,12,14-16H2,1-6H3,(H,30,31)(H,33,34)	QQYRFFPVPWVDLU-UHFFFAOYSA-N	390656	US9957235, 2-242::US10442772, Example 2-242	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390656	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390656&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319038	404959131							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780671	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CC(O)=O)c(F)cc12	InChI=1S/C26H29F4N3O3/c1-24(2)12-17(13-25(3,4)14-24)33-21-11-19(27)15(10-22(34)35)9-20(21)32-23(33)31-16-5-7-18(8-6-16)36-26(28,29)30/h5-9,11,17H,10,12-14H2,1-4H3,(H,31,32)(H,34,35)	LDMNQLQAEWVAHO-UHFFFAOYSA-N	390657	US9957235, 2-243::US10442772, Example 2-243	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 200							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390657&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310785	404959132							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780672	COc1cc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2cc1CC(O)=O	InChI=1S/C29H39N3O3/c1-18(2)19-8-10-21(11-9-19)30-27-31-23-12-20(13-26(33)34)25(35-7)14-24(23)32(27)22-15-28(3,4)17-29(5,6)16-22/h8-12,14,18,22H,13,15-17H2,1-7H3,(H,30,31)(H,33,34)	KUDGFDHBBRMCNF-UHFFFAOYSA-N	390658	US9957235, 2-244::US10442772, Example 2-244	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390658	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390658&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319029	404959133							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780673	COc1cc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1CC(O)=O	InChI=1S/C27H32F3N3O4/c1-25(2)13-18(14-26(3,4)15-25)33-21-12-22(36-5)16(11-23(34)35)10-20(21)32-24(33)31-17-6-8-19(9-7-17)37-27(28,29)30/h6-10,12,18H,11,13-15H2,1-5H3,(H,31,32)(H,34,35)	AQKJCKXDYIBPFR-UHFFFAOYSA-N	390659	US9957235, 2-245::US10442772, Example 2-245	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390659&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310559	404959134							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780674	COc1cc2n(C3CC(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1CC(O)=O	InChI=1S/C26H30F3N3O4/c1-15-9-18(14-25(2,3)13-15)32-21-12-22(35-4)16(11-23(33)34)10-20(21)31-24(32)30-17-5-7-19(8-6-17)36-26(27,28)29/h5-8,10,12,15,18H,9,11,13-14H2,1-4H3,(H,30,31)(H,33,34)	XFHJFTNABYBOGI-UHFFFAOYSA-N	390660	US9957235, 2-246-2::US9957235, 2-246-1::US10442772, Example 2-246-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 190							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390660	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390660&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118314752	404959135							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780675	COc1cc2n(C3CC(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1CC(O)=O	InChI=1S/C26H30F3N3O4/c1-15-9-18(14-25(2,3)13-15)32-21-12-22(35-4)16(11-23(33)34)10-20(21)31-24(32)30-17-5-7-19(8-6-17)36-26(27,28)29/h5-8,10,12,15,18H,9,11,13-14H2,1-4H3,(H,30,31)(H,33,34)	XFHJFTNABYBOGI-UHFFFAOYSA-N	390660	US9957235, 2-246-2::US9957235, 2-246-1::US10442772, Example 2-246-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390660	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390660&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118314752	404959135							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780676	COc1cc2n(C3CC(C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2cc1CC(O)=O	InChI=1S/C28H37N3O3/c1-17(2)19-7-9-21(10-8-19)29-27-30-23-12-20(13-26(32)33)25(34-6)14-24(23)31(27)22-11-18(3)15-28(4,5)16-22/h7-10,12,14,17-18,22H,11,13,15-16H2,1-6H3,(H,29,30)(H,32,33)	OLGPLGPOVKGOOE-UHFFFAOYSA-N	390662	US9957235, 2-247-2::US9957235, 2-247-1::US10442772, Example 2-247-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 60.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390662	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390662&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310737	404959136							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780677	COc1cc2n(C3CC(C)CC(C)(C)C3)c(Nc3ccc(cc3)C(C)C)nc2cc1CC(O)=O	InChI=1S/C28H37N3O3/c1-17(2)19-7-9-21(10-8-19)29-27-30-23-12-20(13-26(32)33)25(34-6)14-24(23)31(27)22-11-18(3)15-28(4,5)16-22/h7-10,12,14,17-18,22H,11,13,15-16H2,1-6H3,(H,29,30)(H,32,33)	OLGPLGPOVKGOOE-UHFFFAOYSA-N	390662	US9957235, 2-247-2::US9957235, 2-247-1::US10442772, Example 2-247-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 8.00							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390662	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390662&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310737	404959136							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780678	COc1cc2n(C3CC(C)CC(C)(C)C3)c(Nc3ccc(OC(C)C)cc3)nc2cc1CC(O)=O	InChI=1S/C28H37N3O4/c1-17(2)35-22-9-7-20(8-10-22)29-27-30-23-12-19(13-26(32)33)25(34-6)14-24(23)31(27)21-11-18(3)15-28(4,5)16-21/h7-10,12,14,17-18,21H,11,13,15-16H2,1-6H3,(H,29,30)(H,32,33)	GEYCTRMDTQZHRU-UHFFFAOYSA-N	390664	US9957235, 2-248-2::US9957235, 2-248-1::US10442772, Example 2-248-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 350							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390664	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390664&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318982	404959137							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780679	COc1cc2n(C3CC(C)CC(C)(C)C3)c(Nc3ccc(OC(C)C)cc3)nc2cc1CC(O)=O	InChI=1S/C28H37N3O4/c1-17(2)35-22-9-7-20(8-10-22)29-27-30-23-12-19(13-26(32)33)25(34-6)14-24(23)31(27)21-11-18(3)15-28(4,5)16-21/h7-10,12,14,17-18,21H,11,13,15-16H2,1-6H3,(H,29,30)(H,32,33)	GEYCTRMDTQZHRU-UHFFFAOYSA-N	390664	US9957235, 2-248-2::US9957235, 2-248-1::US10442772, Example 2-248-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390664	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390664&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118318982	404959137							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780680	CC(C)c1ccc(Nc2nc3cc(CC(O)=O)c(F)cc3n2C2CC(C)CC(C)(C)C2)cc1	InChI=1S/C27H34FN3O2/c1-16(2)18-6-8-20(9-7-18)29-26-30-23-11-19(12-25(32)33)22(28)13-24(23)31(26)21-10-17(3)14-27(4,5)15-21/h6-9,11,13,16-17,21H,10,12,14-15H2,1-5H3,(H,29,30)(H,32,33)	LDTUJXQAJHFZTM-UHFFFAOYSA-N	390666	US9957235, 2-249-2::US9957235, 2-249-1::US10442772, Example 2-249-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 150							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390666	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390666&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310651	404959138							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780681	CC(C)c1ccc(Nc2nc3cc(CC(O)=O)c(F)cc3n2C2CC(C)CC(C)(C)C2)cc1	InChI=1S/C27H34FN3O2/c1-16(2)18-6-8-20(9-7-18)29-26-30-23-11-19(12-25(32)33)22(28)13-24(23)31(26)21-10-17(3)14-27(4,5)15-21/h6-9,11,13,16-17,21H,10,12,14-15H2,1-5H3,(H,29,30)(H,32,33)	LDTUJXQAJHFZTM-UHFFFAOYSA-N	390666	US9957235, 2-249-2::US9957235, 2-249-1::US10442772, Example 2-249-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390666	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390666&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310651	404959138							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780682	CC(C)Oc1ccc(Nc2nc3cc(CC(O)=O)c(F)cc3n2C2CC(C)CC(C)(C)C2)cc1	InChI=1S/C27H34FN3O3/c1-16(2)34-21-8-6-19(7-9-21)29-26-30-23-11-18(12-25(32)33)22(28)13-24(23)31(26)20-10-17(3)14-27(4,5)15-20/h6-9,11,13,16-17,20H,10,12,14-15H2,1-5H3,(H,29,30)(H,32,33)	JVAIZCSWEWGEEW-UHFFFAOYSA-N	390668	US9957235, 2-250-2::US9957235, 2-250-1::US10442772, Example 2-250-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 1200							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390668	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390668&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310647	404959139							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780683	CC(C)Oc1ccc(Nc2nc3cc(CC(O)=O)c(F)cc3n2C2CC(C)CC(C)(C)C2)cc1	InChI=1S/C27H34FN3O3/c1-16(2)34-21-8-6-19(7-9-21)29-26-30-23-11-18(12-25(32)33)22(28)13-24(23)31(26)20-10-17(3)14-27(4,5)15-20/h6-9,11,13,16-17,20H,10,12,14-15H2,1-5H3,(H,29,30)(H,32,33)	JVAIZCSWEWGEEW-UHFFFAOYSA-N	390668	US9957235, 2-250-2::US9957235, 2-250-1::US10442772, Example 2-250-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 280							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390668	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390668&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310647	404959139							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780684	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CC(O)=O)c(F)cc12	InChI=1S/C25H27F4N3O3/c1-14-8-17(13-24(2,3)12-14)32-21-11-19(26)15(10-22(33)34)9-20(21)31-23(32)30-16-4-6-18(7-5-16)35-25(27,28)29/h4-7,9,11,14,17H,8,10,12-13H2,1-3H3,(H,30,31)(H,33,34)	LWYUOIJTRLWRLA-UHFFFAOYSA-N	390670	US9957235, 2-251-2::US9957235, 2-251-1::US10442772, Example 2-251-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 600							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390670	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390670&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319019	404959140							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780685	CC1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CC(O)=O)c(F)cc12	InChI=1S/C25H27F4N3O3/c1-14-8-17(13-24(2,3)12-14)32-21-11-19(26)15(10-22(33)34)9-20(21)31-23(32)30-16-4-6-18(7-5-16)35-25(27,28)29/h4-7,9,11,14,17H,8,10,12-13H2,1-3H3,(H,30,31)(H,33,34)	LWYUOIJTRLWRLA-UHFFFAOYSA-N	390670	US9957235, 2-251-2::US9957235, 2-251-1::US10442772, Example 2-251-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 50.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390670	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390670&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118319019	404959140							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780686	CC1(C)CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2c(F)c(CCC(O)=O)ccc12	InChI=1S/C27H31F4N3O3/c1-25(2)13-18(14-26(3,4)15-25)34-20-11-5-16(6-12-21(35)36)22(28)23(20)33-24(34)32-17-7-9-19(10-8-17)37-27(29,30)31/h5,7-11,18H,6,12-15H2,1-4H3,(H,32,33)(H,35,36)	MNCMGFHRPPEIRQ-UHFFFAOYSA-N	390672	3-[4-fluoro-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazol-5-yl]propanoic acid::US9957235, 2-254::US10442772, Example 2-254	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390672	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390672&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310681	404959141							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780687	CC(C)Oc1ccc(Nc2nc3c(F)c(CCC(O)=O)ccc3n2C2CC(C)(C)CC(C)(C)C2)cc1	InChI=1S/C29H38FN3O3/c1-18(2)36-22-11-9-20(10-12-22)31-27-32-26-23(13-7-19(25(26)30)8-14-24(34)35)33(27)21-15-28(3,4)17-29(5,6)16-21/h7,9-13,18,21H,8,14-17H2,1-6H3,(H,31,32)(H,34,35)	GARRPMJMNOEDDE-UHFFFAOYSA-N	390673	3-{4-fluoro-2-[(4-isopropoxyphenyl)amino]-1-(3,3,5,5-tetramethylcyclohexyl)-1H-benzimidazol-5-yl}propanoic acid::US9957235, 2-255::US10442772, Example 2-255	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390673	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390673&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310337	404959142							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780688	CN(C)C(=O)CCc1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1F	InChI=1S/C29H36F4N4O2/c1-27(2)15-20(16-28(3,4)17-27)37-22-13-7-18(8-14-23(38)36(5)6)24(30)25(22)35-26(37)34-19-9-11-21(12-10-19)39-29(31,32)33/h7,9-13,20H,8,14-17H2,1-6H3,(H,34,35)	ZIFXWRWUIMRLQI-UHFFFAOYSA-N	390674	US9957235, 2-256-2::US9957235, 2-256-1::US9957235, 2-256	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 310							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390674	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390674&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011698	404959143							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780689	CN(C)C(=O)CCc1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1F	InChI=1S/C29H36F4N4O2/c1-27(2)15-20(16-28(3,4)17-27)37-22-13-7-18(8-14-23(38)36(5)6)24(30)25(22)35-26(37)34-19-9-11-21(12-10-19)39-29(31,32)33/h7,9-13,20H,8,14-17H2,1-6H3,(H,34,35)	ZIFXWRWUIMRLQI-UHFFFAOYSA-N	390674	US9957235, 2-256-2::US9957235, 2-256-1::US9957235, 2-256	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 800							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390674	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390674&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011698	404959143							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780690	CN(C)C(=O)CCc1ccc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1F	InChI=1S/C29H36F4N4O2/c1-27(2)15-20(16-28(3,4)17-27)37-22-13-7-18(8-14-23(38)36(5)6)24(30)25(22)35-26(37)34-19-9-11-21(12-10-19)39-29(31,32)33/h7,9-13,20H,8,14-17H2,1-6H3,(H,34,35)	ZIFXWRWUIMRLQI-UHFFFAOYSA-N	390674	US9957235, 2-256-2::US9957235, 2-256-1::US9957235, 2-256	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 500							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390674	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390674&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011698	404959143							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780691	C[C@@H]1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(=O)N(C)C3CC3)ccc12 |r|	InChI=1S/C30H37F3N4O2/c1-19-15-23(18-29(2,3)17-19)37-26-13-5-20(6-14-27(38)36(4)22-9-10-22)16-25(26)35-28(37)34-21-7-11-24(12-8-21)39-30(31,32)33/h5,7-8,11-13,16,19,22-23H,6,9-10,14-15,17-18H2,1-4H3,(H,34,35)	YYFWATPYDLEYON-UHFFFAOYSA-N	390677	US9957235, 2-257-2::US9957235, 2-257-1::US9957235, 2-257	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 600							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390677	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390677&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011699	404959144							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780692	C[C@@H]1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(=O)N(C)C3CC3)ccc12 |r|	InChI=1S/C30H37F3N4O2/c1-19-15-23(18-29(2,3)17-19)37-26-13-5-20(6-14-27(38)36(4)22-9-10-22)16-25(26)35-28(37)34-21-7-11-24(12-8-21)39-30(31,32)33/h5,7-8,11-13,16,19,22-23H,6,9-10,14-15,17-18H2,1-4H3,(H,34,35)	YYFWATPYDLEYON-UHFFFAOYSA-N	390677	US9957235, 2-257-2::US9957235, 2-257-1::US9957235, 2-257	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2000							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390677	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390677&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011699	404959144							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
780693	C[C@@H]1CC(CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(=O)N(C)C3CC3)ccc12 |r|	InChI=1S/C30H37F3N4O2/c1-19-15-23(18-29(2,3)17-19)37-26-13-5-20(6-14-27(38)36(4)22-9-10-22)16-25(26)35-28(37)34-21-7-11-24(12-8-21)39-30(31,32)33/h5,7-8,11-13,16,19,22-23H,6,9-10,14-15,17-18H2,1-4H3,(H,34,35)	YYFWATPYDLEYON-UHFFFAOYSA-N	390677	US9957235, 2-257-2::US9957235, 2-257-1::US9957235, 2-257	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 400							US Patent		10.7270/Q2ZS2ZW7		aid1798826	US9957235	Rehwinkel, H; Panknin, O; Ring, S; Anlauf, S; Siebeneicher, H; Nguyen, D; Schwede, W; Bauser, M; Zimmermann, K; Kaulfuss, S; Neuhaus, R; Blaney, PM	5/1/2018	3/23/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=390677	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=390677&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			146011699	404959144							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
808590	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(O)=O)ccc12 |r|	InChI=1S/C26H30F3N3O3/c1-16-12-19(15-25(2,3)14-16)32-22-10-4-17(5-11-23(33)34)13-21(22)31-24(32)30-18-6-8-20(9-7-18)35-26(27,28)29/h4,6-10,13,16,19H,5,11-12,14-15H2,1-3H3,(H,30,31)(H,33,34)	RNMAUIMMNAHKQR-UHFFFAOYSA-N	404661	US10344004, Test compound Table 3::US10442772, Example 2-118-1::US11376246, Cpd ID Bay1436032::US11576906, Compound Bay143603-2::US11311527, Cpd ID Bay 1436032	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2BZ68DB		aid1799718	US10344004	Schirmer, H	7/9/2019	6/8/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=404661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=404661&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			118310260	406795413							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818373	COC(=O)c1ccc2n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1 |r|	InChI=1S/C26H30F3N3O3/c1-15(2)20-11-5-16(3)13-23(20)32-22-12-6-17(24(33)34-4)14-21(22)31-25(32)30-18-7-9-19(10-8-18)35-26(27,28)29/h6-10,12,14-16,20,23H,5,11,13H2,1-4H3,(H,30,31)	ABFCTOUWEVWWGD-UHFFFAOYSA-N	409994	methyl 1-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]-2-{[4-(trifluoromethoxy)-phenyl]amino}-1H-benzimidazole-5-carboxylate::US10370339, Example 2-4::US10370339, Example 2-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 120							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409994	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409994&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124125999	406791562							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818374	COC(=O)c1ccc2n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(Nc3ccc(cc3)C(C)C)nc2c1 |r|	InChI=1S/C28H37N3O2/c1-17(2)20-8-11-22(12-9-20)29-28-30-24-16-21(27(32)33-6)10-14-25(24)31(28)26-15-19(5)7-13-23(26)18(3)4/h8-12,14,16-19,23,26H,7,13,15H2,1-6H3,(H,29,30)	PYTMHGDVJMPFBN-UHFFFAOYSA-N	409995	US10370339, Example 2-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 65.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409995	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409995&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			134607614	406791563							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818375	COC(=O)c1ccc2n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(Nc3ccc(OC(C)C)cc3)nc2c1 |r|	InChI=1S/C28H37N3O3/c1-17(2)23-13-7-19(5)15-26(23)31-25-14-8-20(27(32)33-6)16-24(25)30-28(31)29-21-9-11-22(12-10-21)34-18(3)4/h8-12,14,16-19,23,26H,7,13,15H2,1-6H3,(H,29,30)	OGDGKDPLKPSEEK-UHFFFAOYSA-N	409996	US10370339, Example 2-3	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 200							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409996	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409996&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124125984	406791564							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818376	COC(=O)c1ccc2n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1 |r|	InChI=1S/C26H30F3N3O3/c1-15(2)20-11-5-16(3)13-23(20)32-22-12-6-17(24(33)34-4)14-21(22)31-25(32)30-18-7-9-19(10-8-18)35-26(27,28)29/h6-10,12,14-16,20,23H,5,11,13H2,1-4H3,(H,30,31)	ABFCTOUWEVWWGD-UHFFFAOYSA-N	409994	methyl 1-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]-2-{[4-(trifluoromethoxy)-phenyl]amino}-1H-benzimidazole-5-carboxylate::US10370339, Example 2-4::US10370339, Example 2-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 38.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409994	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409994&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124125999	406791562							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818377	COC(=O)c1cc2nc(Nc3ccc(cc3)C(C)C)n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c2cc1C |r|	InChI=1S/C29H39N3O2/c1-17(2)21-9-11-22(12-10-21)30-29-31-25-16-24(28(33)34-7)20(6)15-27(25)32(29)26-14-19(5)8-13-23(26)18(3)4/h9-12,15-19,23,26H,8,13-14H2,1-7H3,(H,30,31)	VVCOSGCYHNKDHZ-UHFFFAOYSA-N	409998	US10370339, Example 2-5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409998	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409998&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124126002	406791565							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818378	COC(=O)c1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c2cc1C |r|	InChI=1S/C29H39N3O3/c1-17(2)23-13-8-19(5)14-26(23)32-27-15-20(6)24(28(33)34-7)16-25(27)31-29(32)30-21-9-11-22(12-10-21)35-18(3)4/h9-12,15-19,23,26H,8,13-14H2,1-7H3,(H,30,31)	RAOULSGNPSVIID-UHFFFAOYSA-N	409999	US10370339, Example 2-6	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 220							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=409999	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=409999&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124126025	406791566							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818379	COC(=O)c1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c2cc1OC |r|	InChI=1S/C27H32F3N3O4/c1-15(2)19-11-6-16(3)12-22(19)33-23-14-24(35-4)20(25(34)36-5)13-21(23)32-26(33)31-17-7-9-18(10-8-17)37-27(28,29)30/h7-10,13-16,19,22H,6,11-12H2,1-5H3,(H,31,32)	YRPARRRJFCYHBG-UHFFFAOYSA-N	410000	US10370339, Example 2-7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 100							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410000	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410000&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124126006	406791567							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818380	COC(=O)c1cc2nc(Nc3ccc(cc3)C(C)C)n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c2cc1OC |r|	InChI=1S/C29H39N3O3/c1-17(2)20-9-11-21(12-10-20)30-29-31-24-15-23(28(33)35-7)27(34-6)16-26(24)32(29)25-14-19(5)8-13-22(25)18(3)4/h9-12,15-19,22,25H,8,13-14H2,1-7H3,(H,30,31)	YQNCQWORZVMXKH-UHFFFAOYSA-N	410001	US10370339, Example 2-8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 130							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410001	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410001&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124125995	406791568							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818381	COC(=O)c1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c2cc1OC |r|	InChI=1S/C29H39N3O4/c1-17(2)22-13-8-19(5)14-25(22)32-26-16-27(34-6)23(28(33)35-7)15-24(26)31-29(32)30-20-9-11-21(12-10-20)36-18(3)4/h9-12,15-19,22,25H,8,13-14H2,1-7H3,(H,30,31)	HZUYYTBXNHFRCJ-UHFFFAOYSA-N	410002	US10370339, Example 2-9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 280							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410002	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410002&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124125993	406791569							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818382	COC(=O)Cc1ccc2n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1 |r|	InChI=1S/C27H32F3N3O3/c1-16(2)21-11-5-17(3)13-24(21)33-23-12-6-18(15-25(34)35-4)14-22(23)32-26(33)31-19-7-9-20(10-8-19)36-27(28,29)30/h6-10,12,14,16-17,21,24H,5,11,13,15H2,1-4H3,(H,31,32)	XVGKLBBKQWUZLO-UHFFFAOYSA-N	410003	US10370339, Example 2-10	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 120							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410003	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410003&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			135130056	406791570							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818383	COC(=O)Cc1ccc2n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(Nc3ccc(cc3)C(C)C)nc2c1 |r|	InChI=1S/C29H39N3O2/c1-18(2)22-9-11-23(12-10-22)30-29-31-25-16-21(17-28(33)34-6)8-14-26(25)32(29)27-15-20(5)7-13-24(27)19(3)4/h8-12,14,16,18-20,24,27H,7,13,15,17H2,1-6H3,(H,30,31)	RLDXVVRQSGREFW-UHFFFAOYSA-N	410004	US10370339, Example 2-11	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410004	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410004&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			135130053	406791571							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818384	COC(=O)Cc1ccc2n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(Nc3ccc(OC(C)C)cc3)nc2c1 |r|	InChI=1S/C29H39N3O3/c1-18(2)24-13-7-20(5)15-27(24)32-26-14-8-21(17-28(33)34-6)16-25(26)31-29(32)30-22-9-11-23(12-10-22)35-19(3)4/h8-12,14,16,18-20,24,27H,7,13,15,17H2,1-6H3,(H,30,31)	YIZIZFSEHKORGC-UHFFFAOYSA-N	410005	US10370339, Example 2-12	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 300							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410005	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410005&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			135130055	406791572							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818385	COC(=O)Cc1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c2cc1C |r|	InChI=1S/C28H34F3N3O3/c1-16(2)22-11-6-17(3)12-24(22)34-25-13-18(4)19(15-26(35)36-5)14-23(25)33-27(34)32-20-7-9-21(10-8-20)37-28(29,30)31/h7-10,13-14,16-17,22,24H,6,11-12,15H2,1-5H3,(H,32,33)	QQCFNEAXFARDHK-UHFFFAOYSA-N	410006	US10370339, Example 2-13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 45.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410006	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410006&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			135130058	406791573							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818386	COC(=O)Cc1cc2nc(Nc3ccc(cc3)C(C)C)n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c2cc1C |r|	InChI=1S/C30H41N3O2/c1-18(2)22-9-11-24(12-10-22)31-30-32-26-16-23(17-29(34)35-7)21(6)15-28(26)33(30)27-14-20(5)8-13-25(27)19(3)4/h9-12,15-16,18-20,25,27H,8,13-14,17H2,1-7H3,(H,31,32)	IFGIGPFIMIUKBC-UHFFFAOYSA-N	410007	US10370339, Example 2-14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 35.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410007	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410007&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			135130057	406791574							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818387	COC(=O)Cc1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c2cc1C |r|	InChI=1S/C30H41N3O3/c1-18(2)25-13-8-20(5)14-27(25)33-28-15-21(6)22(17-29(34)35-7)16-26(28)32-30(33)31-23-9-11-24(12-10-23)36-19(3)4/h9-12,15-16,18-20,25,27H,8,13-14,17H2,1-7H3,(H,31,32)	UWZAIYZRJHWSQM-UHFFFAOYSA-N	410008	US10370339, Example 2-15	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410008	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410008&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			135130059	406791575							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818388	COC(=O)Cc1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c2cc1OC |r|	InChI=1S/C28H34F3N3O4/c1-16(2)21-11-6-17(3)12-23(21)34-24-15-25(36-4)18(14-26(35)37-5)13-22(24)33-27(34)32-19-7-9-20(10-8-19)38-28(29,30)31/h7-10,13,15-17,21,23H,6,11-12,14H2,1-5H3,(H,32,33)	QWNSMGSIFHOECC-UHFFFAOYSA-N	410009	US10370339, Example 2-16	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410009	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410009&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			135130054	406791576							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818389	COC(=O)Cc1cc2nc(Nc3ccc(cc3)C(C)C)n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c2cc1OC |r|	InChI=1S/C30H41N3O3/c1-18(2)21-9-11-23(12-10-21)31-30-32-25-15-22(16-29(34)36-7)28(35-6)17-27(25)33(30)26-14-20(5)8-13-24(26)19(3)4/h9-12,15,17-20,24,26H,8,13-14,16H2,1-7H3,(H,31,32)	NUAYHKBDCGPYGR-UHFFFAOYSA-N	410010	US10370339, Example 2-17	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 68.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410010	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410010&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			135130050	406791577							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818390	COC(=O)Cc1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c2cc1OC |r|	InChI=1S/C30H41N3O4/c1-18(2)24-13-8-20(5)14-26(24)33-27-17-28(35-6)21(16-29(34)36-7)15-25(27)32-30(33)31-22-9-11-23(12-10-22)37-19(3)4/h9-12,15,17-20,24,26H,8,13-14,16H2,1-7H3,(H,31,32)	DVXUMPBNIYZYKT-UHFFFAOYSA-N	410011	US10370339, Example 2-18	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 120							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410011	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410011&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			135130060	406791578							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818391	COC(=O)CCc1ccc2n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(Nc3ccc(OC(F)(F)F)cc3)nc2c1 |r|	InChI=1S/C28H34F3N3O3/c1-17(2)22-12-5-18(3)15-25(22)34-24-13-6-19(7-14-26(35)36-4)16-23(24)33-27(34)32-20-8-10-21(11-9-20)37-28(29,30)31/h6,8-11,13,16-18,22,25H,5,7,12,14-15H2,1-4H3,(H,32,33)	SNXYBBFFAFARLT-UHFFFAOYSA-N	410012	US10370339, Example 2-19	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 95.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410012	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410012&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124126021	406791579							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818392	COC(=O)CCc1ccc2n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(Nc3ccc(cc3)C(C)C)nc2c1 |r|	InChI=1S/C30H41N3O2/c1-19(2)23-10-12-24(13-11-23)31-30-32-26-18-22(9-16-29(34)35-6)8-15-27(26)33(30)28-17-21(5)7-14-25(28)20(3)4/h8,10-13,15,18-21,25,28H,7,9,14,16-17H2,1-6H3,(H,31,32)	ABOGRSYSLXIKNP-UHFFFAOYSA-N	410013	US10370339, Example 2-20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 130							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410013	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410013&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124126035	406791580							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818393	COC(=O)CCc1ccc2n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(Nc3ccc(OC(C)C)cc3)nc2c1 |r|	InChI=1S/C30H41N3O3/c1-19(2)25-14-7-21(5)17-28(25)33-27-15-8-22(9-16-29(34)35-6)18-26(27)32-30(33)31-23-10-12-24(13-11-23)36-20(3)4/h8,10-13,15,18-21,25,28H,7,9,14,16-17H2,1-6H3,(H,31,32)	WUFJWAPNZWPWOK-UHFFFAOYSA-N	410014	US10370339, Example 2-21	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 380							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410014	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410014&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124125987	406791581							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818394	CC(C)[C@@H]1CC[C@@H](C)C[C@H]1n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(O)=O |r|	InChI=1S/C25H28F3N3O3/c1-14(2)19-10-4-15(3)12-22(19)31-21-11-5-16(23(32)33)13-20(21)30-24(31)29-17-6-8-18(9-7-17)34-25(26,27)28/h5-9,11,13-15,19,22H,4,10,12H2,1-3H3,(H,29,30)(H,32,33)	RORHNUNCJILUEK-UHFFFAOYSA-N	410015	1-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]-2-{[4-(trifluoromethoxy)phenyl]-amino}-1H-benzimidazole-5-carboxylic acid::US10370339, Example 2-22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 4.00							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410015	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410015&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124126013	406791582							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818395	CC(C)[C@@H]1CC[C@@H](C)C[C@H]1n1c(Nc2ccc(cc2)C(C)C)nc2cc(ccc12)C(O)=O |r|	InChI=1S/C27H35N3O2/c1-16(2)19-7-10-21(11-8-19)28-27-29-23-15-20(26(31)32)9-13-24(23)30(27)25-14-18(5)6-12-22(25)17(3)4/h7-11,13,15-18,22,25H,6,12,14H2,1-5H3,(H,28,29)(H,31,32)	YXEPASYRFUUDAN-UHFFFAOYSA-N	410016	US10370339, Example 2-23	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 6.30							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410016	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410016&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			134607611	406791583							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818396	CC(C)Oc1ccc(Nc2nc3cc(ccc3n2[C@@H]2C[C@H](C)CC[C@H]2C(C)C)C(O)=O)cc1 |r|	InChI=1S/C27H35N3O3/c1-16(2)22-12-6-18(5)14-25(22)30-24-13-7-19(26(31)32)15-23(24)29-27(30)28-20-8-10-21(11-9-20)33-17(3)4/h7-11,13,15-18,22,25H,6,12,14H2,1-5H3,(H,28,29)(H,31,32)	HMFAIINJGRHKTO-UHFFFAOYSA-N	410017	US10370339, Example 2-24	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 13.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410017	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410017&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			134607613	406791584							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818397	CC(C)[C@@H]1CC[C@@H](C)C[C@H]1n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(C(O)=O)c(C)cc12 |r|	InChI=1S/C26H30F3N3O3/c1-14(2)19-10-5-15(3)11-22(19)32-23-12-16(4)20(24(33)34)13-21(23)31-25(32)30-17-6-8-18(9-7-17)35-26(27,28)29/h6-9,12-15,19,22H,5,10-11H2,1-4H3,(H,30,31)(H,33,34)	WORLWJVTZRRZRQ-UHFFFAOYSA-N	410018	US10370339, Example 2-25	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 8.00							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410018	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410018&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124126011	406791585							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818398	CC(C)[C@@H]1CC[C@@H](C)C[C@H]1n1c(Nc2ccc(cc2)C(C)C)nc2cc(C(O)=O)c(C)cc12 |r|	InChI=1S/C28H37N3O2/c1-16(2)20-8-10-21(11-9-20)29-28-30-24-15-23(27(32)33)19(6)14-26(24)31(28)25-13-18(5)7-12-22(25)17(3)4/h8-11,14-18,22,25H,7,12-13H2,1-6H3,(H,29,30)(H,32,33)	FRJZIYSZOOYBNN-UHFFFAOYSA-N	410019	US10370339, Example 2-26	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 7.50							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410019	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410019&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124126009	406791586							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818399	CC(C)Oc1ccc(Nc2nc3cc(C(O)=O)c(C)cc3n2[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1 |r|	InChI=1S/C28H37N3O3/c1-16(2)22-12-7-18(5)13-25(22)31-26-14-19(6)23(27(32)33)15-24(26)30-28(31)29-20-8-10-21(11-9-20)34-17(3)4/h8-11,14-18,22,25H,7,12-13H2,1-6H3,(H,29,30)(H,32,33)	LRKXBURWCRTEFI-UHFFFAOYSA-N	410020	US10370339, Example 2-27	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 15.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410020	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410020&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124125994	406791587							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818400	COc1cc2n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C(O)=O |r|	InChI=1S/C26H30F3N3O4/c1-14(2)18-10-5-15(3)11-21(18)32-22-13-23(35-4)19(24(33)34)12-20(22)31-25(32)30-16-6-8-17(9-7-16)36-26(27,28)29/h6-9,12-15,18,21H,5,10-11H2,1-4H3,(H,30,31)(H,33,34)	FMRRMUGMYZFHDI-UHFFFAOYSA-N	410021	US10370339, Example 2-28	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 16.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410021	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410021&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			134607607	406791588							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818401	COc1cc2n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(Nc3ccc(cc3)C(C)C)nc2cc1C(O)=O |r|	InChI=1S/C28H37N3O3/c1-16(2)19-8-10-20(11-9-19)29-28-30-23-14-22(27(32)33)26(34-6)15-25(23)31(28)24-13-18(5)7-12-21(24)17(3)4/h8-11,14-18,21,24H,7,12-13H2,1-6H3,(H,29,30)(H,32,33)	KGEZQDQKTZNUOB-UHFFFAOYSA-N	410022	US10370339, Example 2-29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 13.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410022	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410022&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124126028	406791589							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818402	COc1cc2n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(Nc3ccc(OC(C)C)cc3)nc2cc1C(O)=O |r|	InChI=1S/C28H37N3O4/c1-16(2)21-12-7-18(5)13-24(21)31-25-15-26(34-6)22(27(32)33)14-23(25)30-28(31)29-19-8-10-20(11-9-19)35-17(3)4/h8-11,14-18,21,24H,7,12-13H2,1-6H3,(H,29,30)(H,32,33)	AXDNWIIZVOTKDX-UHFFFAOYSA-N	410023	US10370339, Example 2-30	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 15.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410023	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410023&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124125990	406791590							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818403	CC(C)[C@@H]1CC[C@@H](C)C[C@H]1n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CC(O)=O)ccc12 |r|	InChI=1S/C26H30F3N3O3/c1-15(2)20-10-4-16(3)12-23(20)32-22-11-5-17(14-24(33)34)13-21(22)31-25(32)30-18-6-8-19(9-7-18)35-26(27,28)29/h5-9,11,13,15-16,20,23H,4,10,12,14H2,1-3H3,(H,30,31)(H,33,34)	GPHDNSKJYLGSQB-UHFFFAOYSA-N	410024	US10370339, Example 2-31	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 14.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410024	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410024&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124125988	406791591							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818404	CC(C)[C@@H]1CC[C@@H](C)C[C@H]1n1c(Nc2ccc(cc2)C(C)C)nc2cc(CC(O)=O)ccc12 |r|	InChI=1S/C28H37N3O2/c1-17(2)21-8-10-22(11-9-21)29-28-30-24-15-20(16-27(32)33)7-13-25(24)31(28)26-14-19(5)6-12-23(26)18(3)4/h7-11,13,15,17-19,23,26H,6,12,14,16H2,1-5H3,(H,29,30)(H,32,33)	WPBBNCPGNNUVOJ-UHFFFAOYSA-N	410025	US10370339, Example 2-32	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 11.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410025	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410025&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			134607582	406791592							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818405	CC(C)Oc1ccc(Nc2nc3cc(CC(O)=O)ccc3n2[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1 |r|	InChI=1S/C28H37N3O3/c1-17(2)23-12-6-19(5)14-26(23)31-25-13-7-20(16-27(32)33)15-24(25)30-28(31)29-21-8-10-22(11-9-21)34-18(3)4/h7-11,13,15,17-19,23,26H,6,12,14,16H2,1-5H3,(H,29,30)(H,32,33)	GHFUQFLTJPFWTQ-UHFFFAOYSA-N	410026	US10370339, Example 2-33	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 45.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410026	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410026&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124126027	406791593							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818406	CC(C)[C@@H]1CC[C@@H](C)C[C@H]1n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CC(O)=O)c(C)cc12 |r|	InChI=1S/C27H32F3N3O3/c1-15(2)21-10-5-16(3)11-23(21)33-24-12-17(4)18(14-25(34)35)13-22(24)32-26(33)31-19-6-8-20(9-7-19)36-27(28,29)30/h6-9,12-13,15-16,21,23H,5,10-11,14H2,1-4H3,(H,31,32)(H,34,35)	YNBOFOREIXXCSY-UHFFFAOYSA-N	410027	US10370339, Example 2-34	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 6.30							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410027	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410027&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124126003	406791594							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818407	CC(C)[C@@H]1CC[C@@H](C)C[C@H]1n1c(Nc2ccc(cc2)C(C)C)nc2cc(CC(O)=O)c(C)cc12 |r|	InChI=1S/C29H39N3O2/c1-17(2)21-8-10-23(11-9-21)30-29-31-25-15-22(16-28(33)34)20(6)14-27(25)32(29)26-13-19(5)7-12-24(26)18(3)4/h8-11,14-15,17-19,24,26H,7,12-13,16H2,1-6H3,(H,30,31)(H,33,34)	XEGISIHJJPNGAX-UHFFFAOYSA-N	410028	US10370339, Example 2-35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 8.30							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410028	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410028&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124126026	406791595							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818408	CC(C)Oc1ccc(Nc2nc3cc(CC(O)=O)c(C)cc3n2[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1 |r|	InChI=1S/C29H39N3O3/c1-17(2)24-12-7-19(5)13-26(24)32-27-14-20(6)21(16-28(33)34)15-25(27)31-29(32)30-22-8-10-23(11-9-22)35-18(3)4/h8-11,14-15,17-19,24,26H,7,12-13,16H2,1-6H3,(H,30,31)(H,33,34)	KCASCHLVWRYFRK-UHFFFAOYSA-N	410029	US10370339, Example 2-36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410029	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410029&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124126015	406791596							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818409	COc1cc2n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1CC(O)=O |r|	InChI=1S/C27H32F3N3O4/c1-15(2)20-10-5-16(3)11-22(20)33-23-14-24(36-4)17(13-25(34)35)12-21(23)32-26(33)31-18-6-8-19(9-7-18)37-27(28,29)30/h6-9,12,14-16,20,22H,5,10-11,13H2,1-4H3,(H,31,32)(H,34,35)	VIYMOJPWOBQQKD-UHFFFAOYSA-N	410030	US10370339, Example 2-37	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 23.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410030	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410030&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124126031	406791597							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818410	COc1cc2n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(Nc3ccc(cc3)C(C)C)nc2cc1CC(O)=O |r|	InChI=1S/C29H39N3O3/c1-17(2)20-8-10-22(11-9-20)30-29-31-24-14-21(15-28(33)34)27(35-6)16-26(24)32(29)25-13-19(5)7-12-23(25)18(3)4/h8-11,14,16-19,23,25H,7,12-13,15H2,1-6H3,(H,30,31)(H,33,34)	XSYZTZMEBAVLJK-UHFFFAOYSA-N	410031	US10370339, Example 2-38	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 12.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410031	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410031&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124125986	406791598							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818411	COc1cc2n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(Nc3ccc(OC(C)C)cc3)nc2cc1CC(O)=O |r|	InChI=1S/C29H39N3O4/c1-17(2)23-12-7-19(5)13-25(23)32-26-16-27(35-6)20(15-28(33)34)14-24(26)31-29(32)30-21-8-10-22(11-9-21)36-18(3)4/h8-11,14,16-19,23,25H,7,12-13,15H2,1-6H3,(H,30,31)(H,33,34)	ARDRQFQMAHBASU-UHFFFAOYSA-N	410032	US10370339, Example 2-39	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410032	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410032&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124126004	406791599							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818412	CC(C)[C@@H]1CC[C@@H](C)C[C@H]1n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(O)=O)ccc12 |r|	InChI=1S/C27H32F3N3O3/c1-16(2)21-11-4-17(3)14-24(21)33-23-12-5-18(6-13-25(34)35)15-22(23)32-26(33)31-19-7-9-20(10-8-19)36-27(28,29)30/h5,7-10,12,15-17,21,24H,4,6,11,13-14H2,1-3H3,(H,31,32)(H,34,35)	BHRRUZQYBYMJMI-UHFFFAOYSA-N	410033	US10370339, Example 2-40	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 15.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410033	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410033&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124126016	406791600							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818413	CC(C)[C@@H]1CC[C@@H](C)C[C@H]1n1c(Nc2ccc(cc2)C(C)C)nc2cc(CCC(O)=O)ccc12 |r|	InChI=1S/C29H39N3O2/c1-18(2)22-9-11-23(12-10-22)30-29-31-25-17-21(8-15-28(33)34)7-14-26(25)32(29)27-16-20(5)6-13-24(27)19(3)4/h7,9-12,14,17-20,24,27H,6,8,13,15-16H2,1-5H3,(H,30,31)(H,33,34)	BAOCPSSJPXUFFT-UHFFFAOYSA-N	410034	US10370339, Example 2-41	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 12.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410034	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410034&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			134607612	406791601							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818414	CC(C)Oc1ccc(Nc2nc3cc(CCC(O)=O)ccc3n2[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1 |r|	InChI=1S/C29H39N3O3/c1-18(2)24-13-6-20(5)16-27(24)32-26-14-7-21(8-15-28(33)34)17-25(26)31-29(32)30-22-9-11-23(12-10-22)35-19(3)4/h7,9-12,14,17-20,24,27H,6,8,13,15-16H2,1-5H3,(H,30,31)(H,33,34)	ZZTIQCGBQGBOBW-UHFFFAOYSA-N	410035	US10370339, Example 2-42	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 12.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410035	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410035&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			135130051	406791602							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818415	COC(=O)CCc1cc2nc(Nc3ccc(OC(F)(F)F)cc3)n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c2cc1OC |r|	InChI=1S/C29H36F3N3O4/c1-17(2)22-12-6-18(3)14-24(22)35-25-16-26(37-4)19(7-13-27(36)38-5)15-23(25)34-28(35)33-20-8-10-21(11-9-20)39-29(30,31)32/h8-11,15-18,22,24H,6-7,12-14H2,1-5H3,(H,33,34)	NQIJSSRDNIHTJV-UHFFFAOYSA-N	410036	methyl 3-(1-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]-6-methoxy-2-{[4-(tri-fluoromethoxy)phenyl]amino}-1H-benzimidazol-5-yl)propanoate::US10370339, Example 2-43	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 190							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410036	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410036&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124126000	406791603							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818416	COC(=O)CCc1cc2nc(Nc3ccc(OC(C)C)cc3)n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c2cc1OC |r|	InChI=1S/C31H43N3O4/c1-19(2)25-14-8-21(5)16-27(25)34-28-18-29(36-6)22(9-15-30(35)37-7)17-26(28)33-31(34)32-23-10-12-24(13-11-23)38-20(3)4/h10-13,17-21,25,27H,8-9,14-16H2,1-7H3,(H,32,33)	XTQYSICEAJMDSM-UHFFFAOYSA-N	410037	US10370339, Example 2-44	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 620							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410037	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410037&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124126024	406791604							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818417	COC(=O)CCc1cc2nc(Nc3ccc(cc3)C(C)C)n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c2cc1OC |r|	InChI=1S/C31H43N3O3/c1-19(2)22-9-12-24(13-10-22)32-31-33-26-17-23(11-15-30(35)37-7)29(36-6)18-28(26)34(31)27-16-21(5)8-14-25(27)20(3)4/h9-10,12-13,17-21,25,27H,8,11,14-16H2,1-7H3,(H,32,33)	KFBOEOYANQULNJ-UHFFFAOYSA-N	410038	US10370339, Example 2-45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 180							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410038	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410038&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124125997	406791605							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818418	COc1cc2n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1CCC(O)=O |r|	InChI=1S/C28H34F3N3O4/c1-16(2)21-11-5-17(3)13-23(21)34-24-15-25(37-4)18(6-12-26(35)36)14-22(24)33-27(34)32-19-7-9-20(10-8-19)38-28(29,30)31/h7-10,14-17,21,23H,5-6,11-13H2,1-4H3,(H,32,33)(H,35,36)	IVTRDPVUMNARMQ-UHFFFAOYSA-N	410039	3-(1-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]-6-methoxy-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazol-5-yl)propanoic acid::US10370339, Example 2-46	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 15.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410039	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410039&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124126005	406791606							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818419	COc1cc2n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(Nc3ccc(OC(C)C)cc3)nc2cc1CCC(O)=O |r|	InChI=1S/C30H41N3O4/c1-18(2)24-13-7-20(5)15-26(24)33-27-17-28(36-6)21(8-14-29(34)35)16-25(27)32-30(33)31-22-9-11-23(12-10-22)37-19(3)4/h9-12,16-20,24,26H,7-8,13-15H2,1-6H3,(H,31,32)(H,34,35)	SIRJDIXFZXAHHR-UHFFFAOYSA-N	410040	US10370339, Example 2-47	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 2800							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410040	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410040&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124125998	406791607							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
818420	COc1cc2n([C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(Nc3ccc(cc3)C(C)C)nc2cc1CCC(O)=O |r|	InChI=1S/C30H41N3O3/c1-18(2)21-8-11-23(12-9-21)31-30-32-25-16-22(10-14-29(34)35)28(36-6)17-27(25)33(30)26-15-20(5)7-13-24(26)19(3)4/h8-9,11-12,16-20,24,26H,7,10,13-15H2,1-6H3,(H,31,32)(H,34,35)	ISEFTOHXTRTNAC-UHFFFAOYSA-N	410041	US10370339, Example 2-48	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 11.0							US Patent		10.7270/Q2M32Z3X		aid1803749	US10370339	Ring, S; Panknin, O; Zimmermann, K; Gunther, J; Barfacker, L	8/6/2019	7/6/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=410041	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=410041&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			124125989	406791608							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822542	Fc1cnc2Nc3cc(F)c(Cl)cc3N(Cc2c1)C(=O)C1CCN(CC(F)(F)F)CC1	InChI=1S/C20H18ClF5N4O/c21-14-6-17-16(7-15(14)23)28-18-12(5-13(22)8-27-18)9-30(17)19(31)11-1-3-29(4-2-11)10-20(24,25)26/h5-8,11H,1-4,9-10H2,(H,27,28)	DHYFKMCPXOXGHI-UHFFFAOYSA-N	412514	US10399972, Example 5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 11.3							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412514&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822543	Fc1cnc2Nc3ccc(cc3N(Cc2c1)C(=O)C1CCN(CC(F)(F)F)CC1)N1C[C@@H]2C[C@H]1CO2 |r|	InChI=1S/C25H27F4N5O2/c26-17-7-16-11-34(24(35)15-3-5-32(6-4-15)14-25(27,28)29)22-9-18(33-12-20-8-19(33)13-36-20)1-2-21(22)31-23(16)30-10-17/h1-2,7,9-10,15,19-20H,3-6,8,11-14H2,(H,30,31)	COJUCQAWOGIMSE-UHFFFAOYSA-N	412515	US10399972, Example 6	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 12.1							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412515&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822544	Fc1cnc2Nc3ccc(cc3N(Cc2c1)C(=O)C1CCN(CC(F)(F)F)CC1)N1[C@@H]2CO[C@@H]3[C@H]1CO[C@H]23 |r,THB:36:37:29.34:32.31|	InChI=1S/C26H27F4N5O3/c27-16-7-15-10-34(25(36)14-3-5-33(6-4-14)13-26(28,29)30)19-8-17(1-2-18(19)32-24(15)31-9-16)35-20-11-37-23-21(35)12-38-22(20)23/h1-2,7-9,14,20-23H,3-6,10-13H2,(H,31,32)	WZPDVHYPXLQPQZ-UHFFFAOYSA-N	412516	US10399972, Example 7::(3-fluoro-8-((3R,3aR,6R,6aR)- hexahydro-3,6-epiminofuro[3,2- b]furan-7-yl)-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 18.5							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412516&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822545	Fc1cnc2Nc3ccc(cc3N(Cc2c1)C(=O)C1CCN(CC(F)(F)F)CC1)N1CC2CCC1CO2	InChI=1S/C26H29F4N5O2/c27-18-9-17-12-35(25(36)16-5-7-33(8-6-16)15-26(28,29)30)23-10-19(2-4-22(23)32-24(17)31-11-18)34-13-21-3-1-20(34)14-37-21/h2,4,9-11,16,20-21H,1,3,5-8,12-15H2,(H,31,32)	BSRVLEPUWIFNMY-UHFFFAOYSA-N	412517	US10399972, Example 9::(8-(2-oxa-5- azabicyclo[2.2.2]octan-5-yl)-3- fluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone::US10399972, Example 8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 25.4							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412517&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822546	Fc1cnc2Nc3ccc(cc3N(Cc2c1)C(=O)C1CCN(CC(F)(F)F)CC1)N1CC2CCC1CO2	InChI=1S/C26H29F4N5O2/c27-18-9-17-12-35(25(36)16-5-7-33(8-6-16)15-26(28,29)30)23-10-19(2-4-22(23)32-24(17)31-11-18)34-13-21-3-1-20(34)14-37-21/h2,4,9-11,16,20-21H,1,3,5-8,12-15H2,(H,31,32)	BSRVLEPUWIFNMY-UHFFFAOYSA-N	412517	US10399972, Example 9::(8-(2-oxa-5- azabicyclo[2.2.2]octan-5-yl)-3- fluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone::US10399972, Example 8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 21.7							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412517&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822547	CO[C@@H]1C[C@@H]2CC[C@H](C1)N2c1ccc2Nc3ncc(F)cc3CN(C(=O)C3CCN(CC(F)(F)F)CC3)c2c1 |r|	InChI=1S/C28H33F4N5O2/c1-39-23-11-20-2-3-21(12-23)37(20)22-4-5-24-25(13-22)36(15-18-10-19(29)14-33-26(18)34-24)27(38)17-6-8-35(9-7-17)16-28(30,31)32/h4-5,10,13-14,17,20-21,23H,2-3,6-9,11-12,15-16H2,1H3,(H,33,34)	JCLZYYACFLEPNI-UHFFFAOYSA-N	412519	US10399972, Example 10::(3-fluoro-8-((1R,3r,5S)-3- methoxy-8- azabicyclo[3.2.1]octan-8-yl)- 5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 6.20							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412519	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412519&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822548	C[C@H]1CN([C@@H](C)CO1)c1ccc2Nc3ncc(F)cc3CN(C(=O)C3CCN(CC(F)(F)F)CC3)c2c1 |r|	InChI=1S/C26H31F4N5O2/c1-16-14-37-17(2)12-34(16)21-3-4-22-23(10-21)35(13-19-9-20(27)11-31-24(19)32-22)25(36)18-5-7-33(8-6-18)15-26(28,29)30/h3-4,9-11,16-18H,5-8,12-15H2,1-2H3,(H,31,32)	YOJXGHRDNATOHP-UHFFFAOYSA-N	412520	US10399972, Example 11::(8-((2S,5S)-2,5- dimethylmorpholino)-3-fluoro- 5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 23.8							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412520&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822549	Fc1cnc2Nc3ccc(cc3N(Cc2c1)C(=O)C1CCN(CC(F)(F)F)CC1)N1CC2(C1)CCCOC2	InChI=1S/C27H31F4N5O2/c28-20-10-19-13-36(25(37)18-4-7-34(8-5-18)16-27(29,30)31)23-11-21(2-3-22(23)33-24(19)32-12-20)35-14-26(15-35)6-1-9-38-17-26/h2-3,10-12,18H,1,4-9,13-17H2,(H,32,33)	GUWDBVNKVRFNQB-UHFFFAOYSA-N	412521	US10399972, Example 12::(3-fluoro-8-(6-oxa-2- azaspiro[3.5]nonan-2-yl)-5,11- dihydro-6H-benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 22.1							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412521&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822550	CC(C)O[C@H]1CC[C@@H](CC1)C(=O)N1Cc2cc(F)cnc2Nc2ccc(cc12)N1CC2CCC1CO2 |r,wU:7.10,wD:4.3,(6.54,2.79,;6.19,4.29,;7.32,5.34,;4.72,4.74,;3.59,3.7,;2.12,4.15,;.99,3.1,;1.34,1.6,;2.81,1.15,;3.94,2.2,;.21,.55,;-1.26,1.01,;.55,-.95,;2.05,-1.29,;2.72,-2.68,;4.25,-2.56,;5.12,-3.83,;6.66,-3.72,;4.45,-5.22,;2.92,-5.34,;2.05,-4.07,;.55,-4.41,;-.65,-3.45,;-1.99,-4.22,;-3.32,-3.45,;-3.32,-1.91,;-1.99,-1.14,;-.65,-1.91,;-4.66,-1.14,;-4.66,.4,;-5.99,1.17,;-5.59,-.32,;-6.77,-.68,;-5.99,-1.91,;-7.32,-1.14,;-7.32,.4,)|	InChI=1S/C28H35FN4O3/c1-17(2)36-23-7-3-18(4-8-23)28(34)33-14-19-11-20(29)13-30-27(19)31-25-10-6-21(12-26(25)33)32-15-24-9-5-22(32)16-35-24/h6,10-13,17-18,22-24H,3-5,7-9,14-16H2,1-2H3,(H,30,31)	CNUHIEXZNDMQEL-UHFFFAOYSA-N	412522	[3-fluoro-8-(2-oxa-5- azabicyclo[2.2.2]oct-5-yl)-5,11- dihydro-6H-pyrido[2,3- b][1,5]benzodiazepin-6-yl][trans- 4-(propan-2- yloxy)cyclohexyl]methanone::US10399972, Example 14::US10399972, Example 13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 35.5							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412522&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822551	CC(C)O[C@H]1CC[C@@H](CC1)C(=O)N1Cc2cc(F)cnc2Nc2ccc(cc12)N1CC2CCC1CO2 |r,wU:7.10,wD:4.3,(6.54,2.79,;6.19,4.29,;7.32,5.34,;4.72,4.74,;3.59,3.7,;2.12,4.15,;.99,3.1,;1.34,1.6,;2.81,1.15,;3.94,2.2,;.21,.55,;-1.26,1.01,;.55,-.95,;2.05,-1.29,;2.72,-2.68,;4.25,-2.56,;5.12,-3.83,;6.66,-3.72,;4.45,-5.22,;2.92,-5.34,;2.05,-4.07,;.55,-4.41,;-.65,-3.45,;-1.99,-4.22,;-3.32,-3.45,;-3.32,-1.91,;-1.99,-1.14,;-.65,-1.91,;-4.66,-1.14,;-4.66,.4,;-5.99,1.17,;-5.59,-.32,;-6.77,-.68,;-5.99,-1.91,;-7.32,-1.14,;-7.32,.4,)|	InChI=1S/C28H35FN4O3/c1-17(2)36-23-7-3-18(4-8-23)28(34)33-14-19-11-20(29)13-30-27(19)31-25-10-6-21(12-26(25)33)32-15-24-9-5-22(32)16-35-24/h6,10-13,17-18,22-24H,3-5,7-9,14-16H2,1-2H3,(H,30,31)	CNUHIEXZNDMQEL-UHFFFAOYSA-N	412522	[3-fluoro-8-(2-oxa-5- azabicyclo[2.2.2]oct-5-yl)-5,11- dihydro-6H-pyrido[2,3- b][1,5]benzodiazepin-6-yl][trans- 4-(propan-2- yloxy)cyclohexyl]methanone::US10399972, Example 14::US10399972, Example 13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 44.3							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412522&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822552	Fc1cnc2Nc3ccc(cc3N(Cc2c1)C(=O)C1CCN(CC(F)(F)F)CC1)N1CC2COCC(C1)O2 |TLB:9:29:32.33.34:37|	InChI=1S/C26H29F4N5O3/c27-18-7-17-10-35(25(36)16-3-5-33(6-4-16)15-26(28,29)30)23-8-19(1-2-22(23)32-24(17)31-9-18)34-11-20-13-37-14-21(12-34)38-20/h1-2,7-9,16,20-21H,3-6,10-15H2,(H,31,32)	CMVGYUNHCNMBRL-UHFFFAOYSA-N	412524	US10399972, Example 15::(8-((1R,5S)-3,9-dioxa-7- azabicyclo[3.3.1]nonan-7-yl)-3- fluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 83.4							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412524	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412524&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822553	CC(C)O[C@H]1CC[C@@H](CC1)C(=O)N1Cc2cc(F)cnc2Nc2ccc(cc12)N1CC2(C1)CCCOC2 |r,wU:7.10,wD:4.3,(6.36,5.88,;5.59,4.54,;6.36,3.21,;4.05,4.54,;3.28,3.21,;1.74,3.21,;.97,1.88,;1.74,.54,;3.28,.54,;4.05,1.88,;.97,-.79,;-.57,-.79,;1.74,-2.12,;3.28,-2.12,;4.24,-3.33,;5.71,-2.87,;6.84,-3.92,;8.31,-3.47,;6.5,-5.42,;5.03,-5.88,;3.9,-4.83,;2.51,-5.5,;1.12,-4.83,;-0,-5.88,;-1.48,-5.42,;-1.82,-3.92,;-.69,-2.87,;.78,-3.33,;-3.29,-3.47,;-4.01,-2.11,;-5.37,-2.83,;-4.65,-4.19,;-6.5,-3.87,;-7.97,-3.42,;-8.31,-1.92,;-7.19,-.87,;-5.71,-1.32,)|	InChI=1S/C29H37FN4O3/c1-19(2)37-24-7-4-20(5-8-24)28(35)34-15-21-12-22(30)14-31-27(21)32-25-9-6-23(13-26(25)34)33-16-29(17-33)10-3-11-36-18-29/h6,9,12-14,19-20,24H,3-5,7-8,10-11,15-18H2,1-2H3,(H,31,32)	KLLFVCBDILTEHS-UHFFFAOYSA-N	412525	US10399972, Example 16::[3-fluoro-8-(6-oxa-2- azaspiro[3.5]non-2-yl)-5,11- dihydro-6H-pyrido[2,3- b][1,5]benzodiazepin-6-yl][trans- 4-(propan-2- yloxy)cyclohexyl]methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 24.0							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412525&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822554	CC(C)O[C@H]1CC[C@@H](CC1)C(=O)N1Cc2cc(F)cnc2Nc2ccc(cc12)N1[C@@H]2CO[C@@H]3[C@H]1CO[C@H]23 |r,wU:33.37,7.10,wD:29.32,32.35,36.40,4.3,THB:35:36:28.33:31.30,(6.9,2.79,;6.56,4.29,;7.69,5.34,;5.09,4.74,;3.96,3.7,;2.49,4.15,;1.36,3.1,;1.7,1.6,;3.17,1.15,;4.3,2.2,;.57,.55,;-.9,1.01,;.92,-.95,;2.42,-1.29,;3.08,-2.68,;4.62,-2.56,;5.49,-3.83,;7.02,-3.72,;4.82,-5.22,;3.28,-5.34,;2.42,-4.07,;.92,-4.41,;-.29,-3.45,;-1.62,-4.22,;-2.96,-3.45,;-2.96,-1.91,;-1.62,-1.14,;-.29,-1.91,;-4.29,-1.14,;-5.06,-2.47,;-6.36,-3.69,;-7.69,-2.92,;-7.69,-1.38,;-5.38,-.05,;-5.78,1.44,;-7.11,.67,;-6.15,-1.38,)|	InChI=1S/C28H33FN4O4/c1-15(2)37-20-6-3-16(4-7-20)28(34)32-12-17-9-18(29)11-30-27(17)31-21-8-5-19(10-22(21)32)33-23-13-35-26-24(33)14-36-25(23)26/h5,8-11,15-16,20,23-26H,3-4,6-7,12-14H2,1-2H3,(H,30,31)	ARSFZXFVYYJXSA-UHFFFAOYSA-N	412526	US10399972, Example 17::(3-fluoro-8-((3R,3aR,6R,6aR)- hexahydro-3,6-epiminofuro[3,2- b]furan-7-yl)-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(trans-4- isopropoxycyclohexyl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 28.4							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412526&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822555	CC(C)O[C@H]1CC[C@@H](CC1)C(=O)N1Cc2cc(F)cnc2Nc2ccc(cc12)N1C[C@@H]2C[C@H]1CO2 |r,wU:7.10,32.35,30.34,wD:4.3,(5.32,3.21,;4.55,4.54,;5.32,5.88,;3.01,4.54,;2.24,3.21,;.7,3.21,;-.07,1.88,;.7,.54,;2.24,.54,;3.01,1.88,;-.07,-.79,;-1.61,-.79,;.7,-2.12,;2.24,-2.12,;3.2,-3.33,;4.67,-2.87,;5.8,-3.92,;7.27,-3.47,;5.46,-5.42,;3.99,-5.88,;2.86,-4.83,;1.47,-5.5,;.08,-4.83,;-1.04,-5.88,;-2.52,-5.42,;-2.86,-3.92,;-1.73,-2.87,;-.26,-3.33,;-4.33,-3.47,;-4.67,-1.97,;-6.14,-1.51,;-6.15,-3.11,;-5.46,-4.52,;-6.93,-4.06,;-7.27,-2.56,)|	InChI=1S/C27H33FN4O3/c1-16(2)35-22-6-3-17(4-7-22)27(33)32-13-18-9-19(28)12-29-26(18)30-24-8-5-20(11-25(24)32)31-14-23-10-21(31)15-34-23/h5,8-9,11-12,16-17,21-23H,3-4,6-7,10,13-15H2,1-2H3,(H,29,30)	WEALFDMDNWSPJG-UHFFFAOYSA-N	412527	US10399972, Example 18::(8-((1S,4S)-2-oxa-5- azabicyclo[2.2.1]heptan-5-yl)-3- fluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(trans-4- isopropoxycyclohexyl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 8.60							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412527	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412527&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822556	CC(C)O[C@H]1CC[C@H](CC1)C(=O)N1Cc2cc(F)cnc2Nc2ccc(cc12)N1C[C@@H]2C[C@H]1CO2 |r,wU:4.3,7.10,32.35,30.34,(5.32,3.21,;4.55,4.54,;5.32,5.88,;3.01,4.54,;2.24,3.21,;3.01,1.88,;2.24,.54,;.7,.54,;-.07,1.88,;.7,3.21,;-.07,-.79,;-1.61,-.79,;.7,-2.12,;2.24,-2.12,;3.2,-3.33,;4.67,-2.87,;5.8,-3.92,;7.27,-3.47,;5.46,-5.42,;3.99,-5.88,;2.86,-4.83,;1.47,-5.5,;.08,-4.83,;-1.04,-5.88,;-2.52,-5.42,;-2.86,-3.92,;-1.73,-2.87,;-.26,-3.33,;-4.33,-3.47,;-4.67,-1.97,;-6.14,-1.51,;-6.15,-3.11,;-5.46,-4.52,;-6.93,-4.06,;-7.27,-2.56,)|	InChI=1S/C27H33FN4O3/c1-16(2)35-22-6-3-17(4-7-22)27(33)32-13-18-9-19(28)12-29-26(18)30-24-8-5-20(11-25(24)32)31-14-23-10-21(31)15-34-23/h5,8-9,11-12,16-17,21-23H,3-4,6-7,10,13-15H2,1-2H3,(H,29,30)	WEALFDMDNWSPJG-UHFFFAOYSA-N	412528	US10399972, Example 19::(8-((1S,4S)-2-oxa-5- azabicyclo[2.2.1]heptan-5-yl)-3- fluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(cis-4- isopropoxycyclohexyl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 6.00							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412528	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412528&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822557	Fc1cnc2Nc3cc(F)c(cc3N(Cc2c1)C(=O)C1CCN(CC(F)(F)F)CC1)N1C[C@@H]2C[C@H]1CO2 |r|	InChI=1S/C25H26F5N5O2/c26-16-5-15-10-35(24(36)14-1-3-33(4-2-14)13-25(28,29)30)22-8-21(34-11-18-6-17(34)12-37-18)19(27)7-20(22)32-23(15)31-9-16/h5,7-9,14,17-18H,1-4,6,10-13H2,(H,31,32)	CGIFUTNZXMUQOR-UHFFFAOYSA-N	412529	US10399972, Example 20::(8-((1S,4S)-2-oxa-5- azabicyclo[2.2.1]heptan-5-yl)- 3,9-difluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 6.70							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412529&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822558	Fc1cnc2Nc3cc(F)c(cc3N(Cc2c1)C(=O)C1CCN(CC(F)(F)F)CC1)N1CC2(C1)CCCOC2	InChI=1S/C27H30F5N5O2/c28-19-8-18-12-37(25(38)17-2-5-35(6-3-17)15-27(30,31)32)23-10-22(20(29)9-21(23)34-24(18)33-11-19)36-13-26(14-36)4-1-7-39-16-26/h8-11,17H,1-7,12-16H2,(H,33,34)	SPYRIRSSUCUKAW-UHFFFAOYSA-N	412530	US10399972, Example 21::(3,9-difluoro-8-(6-oxa-2- azaspiro[3.5]nonan-2-yl)-5,11- dihydro-6H-benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 4.50							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412530&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822559	Fc1cnc2Nc3cc(F)c(cc3N(Cc2c1)C(=O)C1CCN(CC(F)(F)F)CC1)N1[C@@H]2CO[C@@H]3[C@H]1CO[C@H]23 |r,THB:37:38:33.32:35.30|	InChI=1S/C26H26F5N5O3/c27-15-5-14-9-35(25(37)13-1-3-34(4-2-13)12-26(29,30)31)19-7-18(16(28)6-17(19)33-24(14)32-8-15)36-20-10-38-23-21(36)11-39-22(20)23/h5-8,13,20-23H,1-4,9-12H2,(H,32,33)	QFUVNTNAZDSGRC-UHFFFAOYSA-N	412531	US10399972, Example 22::(3,9-difluoro-8- ((3R,3aR,6R,6aR)-hexahydro- 3,6-epiminofuro[3,2-b]furan-7- yl)-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 4.20							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412531&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822560	C[C@H]1CN([C@@H](C)CO1)c1cc2N(Cc3cc(F)cnc3Nc2cc1F)C(=O)C1CCN(CC(F)(F)F)CC1 |r|	InChI=1S/C26H30F5N5O2/c1-15-13-38-16(2)11-35(15)22-9-23-21(8-20(22)28)33-24-18(7-19(27)10-32-24)12-36(23)25(37)17-3-5-34(6-4-17)14-26(29,30)31/h7-10,15-17H,3-6,11-14H2,1-2H3,(H,32,33)	JINPDYPCNIXNAH-UHFFFAOYSA-N	412532	US10399972, Example 23::(8-((2S,5S)-2,5- dimethylmorpholino)-3,9- difluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 23.0							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412532	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412532&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822561	CC(C)O[C@H]1CC[C@@H](CC1)C(=O)N1Cc2cc(F)cnc2Nc2cc(F)c(cc12)N1C[C@@H]2C[C@H]1CO2 |r,wU:31.35,33.36,7.10,wD:4.3,(6.54,2.79,;6.19,4.29,;7.32,5.34,;4.72,4.74,;3.59,3.7,;2.12,4.15,;.99,3.1,;1.34,1.6,;2.81,1.15,;3.94,2.2,;.21,.55,;-1.26,1.01,;.55,-.95,;2.05,-1.29,;2.72,-2.68,;4.25,-2.56,;5.12,-3.83,;6.66,-3.72,;4.45,-5.22,;2.92,-5.34,;2.05,-4.07,;.55,-4.41,;-.65,-3.45,;-1.99,-4.22,;-3.32,-3.45,;-4.66,-4.22,;-3.32,-1.91,;-1.99,-1.14,;-.65,-1.91,;-4.66,-1.14,;-4.66,.4,;-5.99,1.17,;-6.24,-.37,;-5.99,-1.91,;-7.32,-1.14,;-7.32,.4,)|	InChI=1S/C27H32F2N4O3/c1-15(2)36-20-5-3-16(4-6-20)27(34)33-12-17-7-18(28)11-30-26(17)31-23-9-22(29)24(10-25(23)33)32-13-21-8-19(32)14-35-21/h7,9-11,15-16,19-21H,3-6,8,12-14H2,1-2H3,(H,30,31)	CHNWNUVCJSDKKR-UHFFFAOYSA-N	412533	US10399972, Example 24::{3,9-difluoro-8-[(1S,4S)-2-oxa-5- azabicyclo[2.2.1]hept-5-yl]-5,11- dihydro-6H-pyrido[2,3- b][1,5]benzodiazepin-6-yl}[trans- 4-(propan-2- yloxy)cyclohexyl]methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5.60							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412533&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822562	CC(C)O[C@H]1CC[C@@H](CC1)C(=O)N1Cc2cc(F)cnc2Nc2cc(F)c(cc12)N1CC2(C1)CCCOC2 |r,wU:7.10,wD:4.3,(6.36,6.17,;5.59,4.84,;6.36,3.51,;4.05,4.84,;3.28,3.51,;1.74,3.51,;.97,2.17,;1.74,.84,;3.28,.84,;4.05,2.17,;.97,-.49,;-.57,-.49,;1.74,-1.83,;3.28,-1.83,;4.24,-3.03,;5.71,-2.58,;6.84,-3.63,;8.31,-3.17,;6.5,-5.13,;5.03,-5.58,;3.9,-4.53,;2.51,-5.2,;1.12,-4.53,;-0,-5.58,;-1.48,-5.13,;-2.6,-6.17,;-1.82,-3.63,;-.69,-2.58,;.78,-3.03,;-3.29,-3.17,;-4.01,-1.81,;-5.37,-2.53,;-4.65,-3.89,;-6.5,-3.58,;-7.97,-3.12,;-8.31,-1.62,;-7.19,-.57,;-5.71,-1.03,)|	InChI=1S/C29H36F2N4O3/c1-18(2)38-22-6-4-19(5-7-22)28(36)35-14-20-10-21(30)13-32-27(20)33-24-11-23(31)25(12-26(24)35)34-15-29(16-34)8-3-9-37-17-29/h10-13,18-19,22H,3-9,14-17H2,1-2H3,(H,32,33)	LHVSTRBGIKJSNB-UHFFFAOYSA-N	412534	US10399972, Example 25::[3,9-difluoro-8-(6-oxa-2- azaspiro[3.5]non-2-yl)-5,11- dihydro-6H-pyrido[2,3- b][1,5]benzodiazepin-6-yl][trans- 4-(propan-2- yloxy)cyclohexyl]methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 7.80							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412534	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412534&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822563	CC(C)O[C@H]1CC[C@@H](CC1)C(=O)N1Cc2cc(F)cnc2Nc2cc(F)c(cc12)N1C2CCC1COC2 |r,wU:7.10,wD:4.3,(6.54,2.79,;6.19,4.29,;7.32,5.34,;4.72,4.74,;3.59,3.7,;2.12,4.15,;.99,3.1,;1.34,1.6,;2.81,1.15,;3.94,2.2,;.21,.55,;-1.26,1.01,;.55,-.95,;2.05,-1.29,;2.72,-2.68,;4.25,-2.56,;5.12,-3.83,;6.66,-3.72,;4.45,-5.22,;2.92,-5.34,;2.05,-4.07,;.55,-4.41,;-.65,-3.45,;-1.99,-4.22,;-3.32,-3.45,;-4.66,-4.22,;-3.32,-1.91,;-1.99,-1.14,;-.65,-1.91,;-4.66,-1.14,;-4.66,.4,;-6.2,.4,;-6.76,-.57,;-5.99,-1.91,;-7.32,-1.14,;-7.32,.4,;-5.99,1.17,)|	InChI=1S/C28H34F2N4O3/c1-16(2)37-22-7-3-17(4-8-22)28(35)33-13-18-9-19(29)12-31-27(18)32-24-10-23(30)25(11-26(24)33)34-20-5-6-21(34)15-36-14-20/h9-12,16-17,20-22H,3-8,13-15H2,1-2H3,(H,31,32)	VTSVVHIHYFKVQE-UHFFFAOYSA-N	412535	US10399972, Example 26::[3,9-difluoro-8-(3-oxa-8- azabicyclo[3.2.1]oct-8-yl)-5,11- dihydro-6H-pyrido[2,3- b][1,5]benzodiazepin-6-yl][trans- 4-(propan-2- yloxy)cyclohexyl]methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 13.8							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412535	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412535&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822564	Fc1cc2Nc3ncccc3CN(C(=O)C3CCN(CC(F)(F)F)CC3)c2cc1N1C[C@@H]2C[C@H]1CO2 |r|	InChI=1S/C25H27F4N5O2/c26-19-9-20-22(10-21(19)33-12-18-8-17(33)13-36-18)34(11-16-2-1-5-30-23(16)31-20)24(35)15-3-6-32(7-4-15)14-25(27,28)29/h1-2,5,9-10,15,17-18H,3-4,6-8,11-14H2,(H,30,31)	IDBXIGIZPJAPHV-UHFFFAOYSA-N	412536	US10399972, Example 27::(8-((1S,4S)-2-oxa-5- azabicyclo[2.2.1]heptan-5-yl)-9- fluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 27.5							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412536	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412536&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822565	Fc1cc2Nc3ncccc3CN(C(=O)C3CCN(CC(F)(F)F)CC3)c2cc1N1[C@@H]2CO[C@@H]3[C@H]1CO[C@H]23 |r,THB:36:37:32.31:34.29|	InChI=1S/C26H27F4N5O3/c27-16-8-17-19(9-18(16)35-20-11-37-23-21(35)12-38-22(20)23)34(10-15-2-1-5-31-24(15)32-17)25(36)14-3-6-33(7-4-14)13-26(28,29)30/h1-2,5,8-9,14,20-23H,3-4,6-7,10-13H2,(H,31,32)	WQNCIVIJMJWPQD-UHFFFAOYSA-N	412537	US10399972, Example 28::(9-fluoro-8-((3R,3aR,6R,6aR)- hexahydro-3,6-epiminofuro[3,2- b]furan-7-yl)-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 27.6							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412537&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822566	Fc1cnc2Nc3cc(F)c(cc3N(Cc2c1)C(=O)C1CCN(CC(F)(F)F)CC1)N1CC2CCC1CO2	InChI=1S/C26H28F5N5O2/c27-17-7-16-11-36(25(37)15-3-5-34(6-4-15)14-26(29,30)31)23-9-22(35-12-19-2-1-18(35)13-38-19)20(28)8-21(23)33-24(16)32-10-17/h7-10,15,18-19H,1-6,11-14H2,(H,32,33)	JAYSMAUSONUIDZ-UHFFFAOYSA-N	412538	US10399972, Example 73::(8-(2-oxa-5- azabicyclo[2.2.2]octan-5-yl)-3,9- difluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone::US10399972, Example 29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 9.90							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412538&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822567	CO[C@@H]1C[C@@H]2CC[C@H](C1)N2c1cc2N(Cc3cc(F)cnc3Nc2cc1F)C(=O)C1CCN(CC(F)(F)F)CC1 |r,THB:10:9:8.2.3:6.5|	InChI=1S/C28H32F5N5O2/c1-40-21-9-19-2-3-20(10-21)38(19)24-12-25-23(11-22(24)30)35-26-17(8-18(29)13-34-26)14-37(25)27(39)16-4-6-36(7-5-16)15-28(31,32)33/h8,11-13,16,19-21H,2-7,9-10,14-15H2,1H3,(H,34,35)	TXFGSJIPKBNCJB-UHFFFAOYSA-N	412539	US10399972, Example 30::(3,9-difluoro-8-((1R,3r,5S)-3- methoxy-8- azabicyclo[3.2.1]octan-8-yl)- 5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 14.1							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412539	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412539&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822568	Fc1cnc2Nc3cc(F)c(cc3N(Cc2c1)C(=O)C1CCN(CC(F)(F)F)CC1)N1C[C@H]2CC[C@@H]1CO2 |r|	InChI=1S/C26H28F5N5O2/c27-17-7-16-11-36(25(37)15-3-5-34(6-4-15)14-26(29,30)31)23-9-22(35-12-19-2-1-18(35)13-38-19)20(28)8-21(23)33-24(16)32-10-17/h7-10,15,18-19H,1-6,11-14H2,(H,32,33)	JAYSMAUSONUIDZ-UHFFFAOYSA-N	412540	US10399972, Example 31::(8-((1R,4R)-2-oxa-5- azabicyclo[2.2.2]octan-5-yl)-3,9- difluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 18.0							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412540&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822569	Fc1cnc2Nc3cc(F)c(cc3N(Cc2c1)C(=O)C1CCN(CC(F)(F)F)CC1)N1C[C@@H]2CC[C@H]1CO2 |r|	InChI=1S/C26H28F5N5O2/c27-17-7-16-11-36(25(37)15-3-5-34(6-4-15)14-26(29,30)31)23-9-22(35-12-19-2-1-18(35)13-38-19)20(28)8-21(23)33-24(16)32-10-17/h7-10,15,18-19H,1-6,11-14H2,(H,32,33)	JAYSMAUSONUIDZ-UHFFFAOYSA-N	412541	US10399972, Example 32::(8-((1S,4S)-2-oxa-5- azabicyclo[2.2.2]octan-5-yl)-3,9- difluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 18.1							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412541&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822570	CC(C)O[C@H]1CC[C@@H](OC1)C(=O)N1Cc2cc(F)cnc2Nc2ccc(cc12)[C@H]1COCCO1 |r|	InChI=1S/C25H30FN3O5/c1-15(2)34-19-4-6-22(33-13-19)25(30)29-12-17-9-18(26)11-27-24(17)28-20-5-3-16(10-21(20)29)23-14-31-7-8-32-23/h3,5,9-11,15,19,22-23H,4,6-8,12-14H2,1-2H3,(H,27,28)	NTBPQMAKDYFKOK-UHFFFAOYSA-N	412542	US10399972, Example 33::(8-((S)-1,4-Dioxan-2-yl)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)((2R,5S)-5-isopropoxytetrahydro-2H-pyran-2-yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 21.8							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412542	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412542&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822571	CC(C)O[C@H]1CC[C@@H](OC1)C(=O)N1Cc2cc(F)cnc2Nc2ccc(cc12)[C@@H]1COCCO1 |r|	InChI=1S/C25H30FN3O5/c1-15(2)34-19-4-6-22(33-13-19)25(30)29-12-17-9-18(26)11-27-24(17)28-20-5-3-16(10-21(20)29)23-14-31-7-8-32-23/h3,5,9-11,15,19,22-23H,4,6-8,12-14H2,1-2H3,(H,27,28)	NTBPQMAKDYFKOK-UHFFFAOYSA-N	412543	US10399972, Example 34::(8-((R)-1,4-dioxan-2-yl)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)((2R,5S)-5-isopropoxytetrahydro-2H-pyran-2-yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 23.4							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412543&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822572	CC(C)O[C@H]1CC[C@@H](OC1)C(=O)N1Cc2cc(F)cnc2Nc2cc(F)c(cc12)[C@H]1COCCO1 |r|	InChI=1S/C25H29F2N3O5/c1-14(2)35-17-3-4-22(34-12-17)25(31)30-11-15-7-16(26)10-28-24(15)29-20-9-19(27)18(8-21(20)30)23-13-32-5-6-33-23/h7-10,14,17,22-23H,3-6,11-13H2,1-2H3,(H,28,29)	CKQLKKZABDREKX-UHFFFAOYSA-N	412544	US10399972, Example 35	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 28.0							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412544&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822573	CC(C)O[C@H]1CC[C@@H](OC1)C(=O)N1Cc2cc(F)cnc2Nc2cc(F)c(cc12)[C@@H]1COCCO1 |r|	InChI=1S/C25H29F2N3O5/c1-14(2)35-17-3-4-22(34-12-17)25(31)30-11-15-7-16(26)10-28-24(15)29-20-9-19(27)18(8-21(20)30)23-13-32-5-6-33-23/h7-10,14,17,22-23H,3-6,11-13H2,1-2H3,(H,28,29)	CKQLKKZABDREKX-UHFFFAOYSA-N	412545	US10399972, Example 36	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 23.7							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412545&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822574	CC(C)O[C@H]1CC[C@@H](OC1)C(=O)N1Cc2cccnc2Nc2cc(F)c(cc12)C1COCCO1 |r|	InChI=1S/C25H30FN3O5/c1-15(2)34-17-5-6-22(33-13-17)25(30)29-12-16-4-3-7-27-24(16)28-20-11-19(26)18(10-21(20)29)23-14-31-8-9-32-23/h3-4,7,10-11,15,17,22-23H,5-6,8-9,12-14H2,1-2H3,(H,27,28)	QKCDIIOEHZUWLP-UHFFFAOYSA-N	412546	(8-(1,4-dioxan-2-yl)-9- fluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6- yl)((2R,5S)-5- isopropoxytetrahydro-2H- pyran-2-yl)methanone::US10399972, Example 38::US10399972, Example 37	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 36.9							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412546	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412546&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822575	CC(C)O[C@H]1CC[C@@H](OC1)C(=O)N1Cc2cccnc2Nc2cc(F)c(cc12)C1COCCO1 |r|	InChI=1S/C25H30FN3O5/c1-15(2)34-17-5-6-22(33-13-17)25(30)29-12-16-4-3-7-27-24(16)28-20-11-19(26)18(10-21(20)29)23-14-31-8-9-32-23/h3-4,7,10-11,15,17,22-23H,5-6,8-9,12-14H2,1-2H3,(H,27,28)	QKCDIIOEHZUWLP-UHFFFAOYSA-N	412546	(8-(1,4-dioxan-2-yl)-9- fluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6- yl)((2R,5S)-5- isopropoxytetrahydro-2H- pyran-2-yl)methanone::US10399972, Example 38::US10399972, Example 37	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 36.0							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412546	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412546&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822576	CO[C@@H]1C[C@@H]2CC[C@H](C1)N2c1ccc2Nc3ncc(F)cc3CN(C(=O)[C@H]3CC[C@@H](CO3)OC(C)C)c2c1 |r|	InChI=1S/C29H37FN4O4/c1-17(2)38-23-7-9-27(37-16-23)29(35)33-15-18-10-19(30)14-31-28(18)32-25-8-6-22(13-26(25)33)34-20-4-5-21(34)12-24(11-20)36-3/h6,8,10,13-14,17,20-21,23-24,27H,4-5,7,9,11-12,15-16H2,1-3H3,(H,31,32)	QGIRHEBZBQTKKE-UHFFFAOYSA-N	412548	US10399972, Example 39	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.4							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412548&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822577	CC(C)O[C@H]1CC[C@@H](OC1)C(=O)N1Cc2cc(F)cnc2Nc2ccc(cc12)N1CC2(C1)CCCOC2 |r|	InChI=1S/C28H35FN4O4/c1-18(2)37-22-5-7-25(36-14-22)27(34)33-13-19-10-20(29)12-30-26(19)31-23-6-4-21(11-24(23)33)32-15-28(16-32)8-3-9-35-17-28/h4,6,10-12,18,22,25H,3,5,7-9,13-17H2,1-2H3,(H,30,31)	RZHDHBCNBOFMJI-UHFFFAOYSA-N	412549	US10399972, Example 40::(3-fluoro-8-(6-oxa-2- azaspiro[3.5]nonan-2-yl)-5,11- dihydro-6H-benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)((2R,5S)-5- isopropoxytetrahydro-2H-pyran- 2-yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 25.5							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412549&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822578	CC(C)O[C@H]1CC[C@@H](OC1)C(=O)N1Cc2cc(F)cnc2Nc2ccc(cc12)N1CC2COCC(C1)O2 |r,TLB:25:28:31.32.33:36|	InChI=1S/C27H33FN4O5/c1-16(2)36-20-4-6-25(35-15-20)27(33)32-10-17-7-18(28)9-29-26(17)30-23-5-3-19(8-24(23)32)31-11-21-13-34-14-22(12-31)37-21/h3,5,7-9,16,20-22,25H,4,6,10-15H2,1-2H3,(H,29,30)	WWEWVBNBHUZXEY-UHFFFAOYSA-N	412550	US10399972, Example 41::(8-((1R,5S)-3,9-dioxa-7- azabicyclo[3.3.1]nonan-7-yl)-3- fluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)((2R,5S)-5- isopropoxytetrahydro-2H-pyran- 2-yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 21.0							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412550&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822579	CC(C)O[C@H]1CC[C@@H](OC1)C(=O)N1Cc2cc(F)cnc2Nc2ccc(NCC3(CCl)CCCOC3)cc12 |r|	InChI=1S/C28H36ClFN4O4/c1-18(2)38-22-5-7-25(37-14-22)27(35)34-13-19-10-20(30)12-31-26(19)33-23-6-4-21(11-24(23)34)32-16-28(15-29)8-3-9-36-17-28/h4,6,10-12,18,22,25,32H,3,5,7-9,13-17H2,1-2H3,(H,31,33)	IAFTVSMJEFWHIF-UHFFFAOYSA-N	412551	US10399972, Example 42::(8-(((3-(chloromethyl)tetrahydro- 2H-pyran-3-yl)methyl)amino)-3- fluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)((2R,5S)-5- isopropoxytetrahydro-2H-pyran- 2-yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 13.6							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412551&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822580	CCS(=O)(=O)N1CCC(CC1)C(=O)N1Cc2cc(F)cnc2Nc2ccc(cc12)N1CC2CCC1CO2	InChI=1S/C26H32FN5O4S/c1-2-37(34,35)30-9-7-17(8-10-30)26(33)32-14-18-11-19(27)13-28-25(18)29-23-6-4-20(12-24(23)32)31-15-22-5-3-21(31)16-36-22/h4,6,11-13,17,21-22H,2-3,5,7-10,14-16H2,1H3,(H,28,29)	LMPPQDRVKKRGBU-UHFFFAOYSA-N	412552	US10399972, Example 43::(8-(2-oxa-5- azabicyclo[2.2.2]octan-5-yl)-3- fluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1- (ethylsulfonyl)piperidin-4- yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 87.0							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412552	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412552&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822581	CC(C)O[C@H]1CC[C@@H](OC1)C(=O)N1Cc2cc(F)cnc2Nc2cc(F)c(cc12)N1CC2CCC1CO2 |r|	InChI=1S/C27H32F2N4O4/c1-15(2)37-20-5-6-25(36-14-20)27(34)33-11-16-7-17(28)10-30-26(16)31-22-8-21(29)23(9-24(22)33)32-12-19-4-3-18(32)13-35-19/h7-10,15,18-20,25H,3-6,11-14H2,1-2H3,(H,30,31)	QCXBHAVBCWSYDI-UHFFFAOYSA-N	412553	US10399972, Example 44::(8-(2-oxa-5- azabicyclo[2.2.2]octan-5-yl)-3,9- difluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)((2R,5S)-5- isopropoxytetrahydro-2H-pyran- 2-yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 11.4							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412553&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822582	CC(C)O[C@H]1CC[C@@H](OC1)C(=O)N1Cc2cc(F)cnc2Nc2cc(F)c(cc12)N1CC2(C1)CCCOC2 |r|	InChI=1S/C28H34F2N4O4/c1-17(2)38-20-4-5-25(37-13-20)27(35)34-12-18-8-19(29)11-31-26(18)32-22-9-21(30)23(10-24(22)34)33-14-28(15-33)6-3-7-36-16-28/h8-11,17,20,25H,3-7,12-16H2,1-2H3,(H,31,32)	MRXLOZJBGMMECX-UHFFFAOYSA-N	412554	US10399972, Example 45	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 18.3							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412554&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822583	CC(C)O[C@H]1CC[C@@H](OC1)C(=O)N1Cc2cc(F)cnc2Nc2cc(F)c(cc12)N1C[C@@H]2C[C@H]1CO2 |r|	InChI=1S/C26H30F2N4O4/c1-14(2)36-18-3-4-24(35-13-18)26(33)32-10-15-5-16(27)9-29-25(15)30-21-7-20(28)22(8-23(21)32)31-11-19-6-17(31)12-34-19/h5,7-9,14,17-19,24H,3-4,6,10-13H2,1-2H3,(H,29,30)	MZDFRCYXOCIWJF-UHFFFAOYSA-N	412555	US10399972, Example 46::(8-((1S,4S)-2-oxa-5- azabicyclo[2.2.1]heptan-5-yl)- 3,9-difluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)((2R,5S)-5- isopropoxytetrahydro-2H-pyran- 2-yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 17.9							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412555&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822584	CO[C@@H]1C[C@@H]2CC[C@H](C1)N2c1cc2N(Cc3cc(F)cnc3Nc2cc1F)C(=O)[C@H]1CC[C@@H](CO1)OC(C)C |r|	InChI=1S/C29H36F2N4O4/c1-16(2)39-21-6-7-27(38-15-21)29(36)34-14-17-8-18(30)13-32-28(17)33-24-11-23(31)25(12-26(24)34)35-19-4-5-20(35)10-22(9-19)37-3/h8,11-13,16,19-22,27H,4-7,9-10,14-15H2,1-3H3,(H,32,33)	YWPFWXZFCBIAJY-UHFFFAOYSA-N	412556	US10399972, Example 47::(3,9-difluoro-8-((1R,3S,5S)-3- methoxy-8- azabicyclo[3.2.1]octan-8-yl)- 5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)((2R,5S)-5- isopropoxytetrahydro-2H-pyran- 2-yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 15.8							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412556&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822585	CC(C)O[C@H]1CC[C@@H](OC1)C(=O)N1Cc2cc(F)cnc2Nc2ccc(cc12)N1C[C@H]2CC[C@@H]1CO2 |r|	InChI=1S/C27H33FN4O4/c1-16(2)36-22-6-8-25(35-15-22)27(33)32-12-17-9-18(28)11-29-26(17)30-23-7-4-19(10-24(23)32)31-13-21-5-3-20(31)14-34-21/h4,7,9-11,16,20-22,25H,3,5-6,8,12-15H2,1-2H3,(H,29,30)	CHPQQBZYSJKTOZ-UHFFFAOYSA-N	412557	US10399972, Example 48::(8-((1R,4R)-2-oxa-5- azabicyclo[2.2.2]octan-5-yl)-3- fluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)((2R,5S)-5- isopropoxytetrahydro-2H-pyran- 2-yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412557&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822586	CC(C)O[C@H]1CC[C@@H](OC1)C(=O)N1Cc2cc(F)cnc2Nc2ccc(cc12)N1C[C@@H]2CC[C@H]1CO2 |r|	InChI=1S/C27H33FN4O4/c1-16(2)36-22-6-8-25(35-15-22)27(33)32-12-17-9-18(28)11-29-26(17)30-23-7-4-19(10-24(23)32)31-13-21-5-3-20(31)14-34-21/h4,7,9-11,16,20-22,25H,3,5-6,8,12-15H2,1-2H3,(H,29,30)	CHPQQBZYSJKTOZ-UHFFFAOYSA-N	412558	US10399972, Example 49::(8-((1S,4S)-2-oxa-5- azabicyclo[2.2.2]octan-5-yl)-3- fluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)((2R,5R)-5- isopropoxytetrahydro-2H-pyran- 2-yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 12.0							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412558&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822587	Cn1nccc1-c1cc2N(Cc3cc(F)cnc3Nc2cc1F)C(=O)C1CCN(CC(F)(F)F)CC1	InChI=1S/C24H23F5N6O/c1-33-20(2-5-31-33)17-9-21-19(10-18(17)26)32-22-15(8-16(25)11-30-22)12-35(21)23(36)14-3-6-34(7-4-14)13-24(27,28)29/h2,5,8-11,14H,3-4,6-7,12-13H2,1H3,(H,30,32)	RAZJGPHPTSDPME-UHFFFAOYSA-N	412559	US10399972, Example 50	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 3.50							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412559&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822588	Fc1cnc2Nc3cc(F)c(cc3N(Cc2c1)C(=O)C1CCN(CC(F)(F)F)CC1)-c1ccn[nH]1	InChI=1S/C23H21F5N6O/c24-15-7-14-11-34(22(35)13-2-5-33(6-3-13)12-23(26,27)28)20-8-16(18-1-4-30-32-18)17(25)9-19(20)31-21(14)29-10-15/h1,4,7-10,13H,2-3,5-6,11-12H2,(H,29,31)(H,30,32)	AAPHSZOSQBDTOT-UHFFFAOYSA-N	412560	US10399972, Example 51::(3,9-difluoro-8-(1H-pyrazol-5- yl)-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 3.60							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412560&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822589	Cn1cc(cn1)-c1cc2N(Cc3cccnc3Nc2cc1F)C(=O)C1CCN(CC(F)(F)F)CC1	InChI=1S/C24H24F4N6O/c1-32-12-17(11-30-32)18-9-21-20(10-19(18)25)31-22-16(3-2-6-29-22)13-34(21)23(35)15-4-7-33(8-5-15)14-24(26,27)28/h2-3,6,9-12,15H,4-5,7-8,13-14H2,1H3,(H,29,31)	JKFNMSRFGJBVPX-UHFFFAOYSA-N	412561	US10399972, Example 52	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5.70							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412561&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822590	Cn1nccc1-c1cc2N(Cc3cccnc3Nc2cc1F)C(=O)C1CCN(CC(F)(F)F)CC1	InChI=1S/C24H24F4N6O/c1-32-20(4-8-30-32)17-11-21-19(12-18(17)25)31-22-16(3-2-7-29-22)13-34(21)23(35)15-5-9-33(10-6-15)14-24(26,27)28/h2-4,7-8,11-12,15H,5-6,9-10,13-14H2,1H3,(H,29,31)	GYKFJQLJBWXMQR-UHFFFAOYSA-N	412562	US10399972, Example 53::(9-fluoro-8-(1-methyl-1H- pyrazol-5-yl)-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 7.20							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412562	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412562&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822591	Fc1cnc2Nc3ccc(cc3N(Cc2c1)C(=O)C1CCN(CC(F)(F)F)CC1)[C@H]1COCCO1 |r|	InChI=1S/C24H26F4N4O3/c25-18-9-17-12-32(23(33)15-3-5-31(6-4-15)14-24(26,27)28)20-10-16(21-13-34-7-8-35-21)1-2-19(20)30-22(17)29-11-18/h1-2,9-11,15,21H,3-8,12-14H2,(H,29,30)	MPFLAFDPSRRPLY-UHFFFAOYSA-N	412563	US10399972, Example 54::(S)-(8-(1,4-Dioxan-2-yl)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5.60							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412563&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822592	Fc1cnc2Nc3ccc(cc3N(Cc2c1)C(=O)C1CCN(CC(F)(F)F)CC1)[C@@H]1COCCO1 |r|	InChI=1S/C24H26F4N4O3/c25-18-9-17-12-32(23(33)15-3-5-31(6-4-15)14-24(26,27)28)20-10-16(21-13-34-7-8-35-21)1-2-19(20)30-22(17)29-11-18/h1-2,9-11,15,21H,3-8,12-14H2,(H,29,30)	MPFLAFDPSRRPLY-UHFFFAOYSA-N	412564	US10399972, Example 55::(R)-(8-(1,4-dioxan-2-yl)-3-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 6.50							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412564&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822593	Fc1cc2Nc3ncccc3CN(C(=O)C3CCN(CC(F)(F)F)CC3)c2cc1[C@@H]1COCCO1 |r|	InChI=1S/C24H26F4N4O3/c25-18-11-19-20(10-17(18)21-13-34-8-9-35-21)32(12-16-2-1-5-29-22(16)30-19)23(33)15-3-6-31(7-4-15)14-24(26,27)28/h1-2,5,10-11,15,21H,3-4,6-9,12-14H2,(H,29,30)	QHFULQDWQFARPU-UHFFFAOYSA-N	412565	US10399972, Example 56::(R)-(8-(1,4-Dioxan-2-yl)-9-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 18.1							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412565&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822594	Fc1cc2Nc3ncccc3CN(C(=O)C3CCN(CC(F)(F)F)CC3)c2cc1[C@H]1COCCO1 |r|	InChI=1S/C24H26F4N4O3/c25-18-11-19-20(10-17(18)21-13-34-8-9-35-21)32(12-16-2-1-5-29-22(16)30-19)23(33)15-3-6-31(7-4-15)14-24(26,27)28/h1-2,5,10-11,15,21H,3-4,6-9,12-14H2,(H,29,30)	QHFULQDWQFARPU-UHFFFAOYSA-N	412566	US10399972, Example 57::(S)-(8-(1,4-dioxan-2-yl)-9-fluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 12.2							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412566&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822595	CC(C)O[C@H]1CCC(CC1)C(=O)N1Cc2cccnc2Nc2cc(C)c(cc12)N1C[C@@H]2CC[C@H]1CO2 |r,wU:30.40,33.37,wD:4.3,(7.32,13.06,;6.19,12.01,;6.54,10.51,;4.72,12.47,;3.59,11.42,;2.12,11.87,;.99,10.83,;1.34,9.33,;2.81,8.87,;3.94,9.92,;.21,8.28,;-1.26,8.73,;.55,6.78,;2.05,6.43,;2.72,5.05,;4.25,5.16,;5.12,3.89,;4.45,2.5,;2.92,2.39,;2.05,3.66,;.55,3.32,;-.65,4.28,;-1.99,3.51,;-3.32,4.28,;-4.66,3.51,;-3.32,5.82,;-1.99,6.59,;-.65,5.82,;-4.66,6.59,;-5.99,5.82,;-7.32,6.59,;-5.8,6.64,;-6.2,8.13,;-4.66,8.13,;-5.99,8.9,;-7.32,8.13,)|	InChI=1S/C29H38N4O3/c1-18(2)36-23-9-6-20(7-10-23)29(34)33-15-21-5-4-12-30-28(21)31-25-13-19(3)26(14-27(25)33)32-16-24-11-8-22(32)17-35-24/h4-5,12-14,18,20,22-24H,6-11,15-17H2,1-3H3,(H,30,31)	HDMHVZJYESAQHW-UHFFFAOYSA-N	412567	US10399972, Example 58::(Trans-4-isopropoxycyclohexyl) 9-methyl-8-[(1S,4S)-2-oxa-5-azabicyclo[2.2.2]oct-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl]methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 18.3							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412567&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822596	CC(C)O[C@H]1CCC(CC1)C(=O)N1Cc2cccnc2Nc2ccc(N3C[C@@H]4CC[C@H]3CO4)c(C)c12 |r,wU:27.35,30.32,wD:4.3,(7.32,13.06,;6.19,12.01,;6.54,10.51,;4.72,12.47,;3.59,11.42,;2.12,11.87,;.99,10.83,;1.34,9.33,;2.81,8.87,;3.94,9.92,;.21,8.28,;-1.26,8.73,;.55,6.78,;2.05,6.43,;2.72,5.05,;4.25,5.16,;5.12,3.89,;4.45,2.5,;2.92,2.39,;2.05,3.66,;.55,3.32,;-.65,4.28,;-1.99,3.51,;-3.32,4.28,;-3.32,5.82,;-4.66,6.59,;-5.99,5.82,;-7.32,6.59,;-5.8,6.64,;-6.2,8.13,;-4.66,8.13,;-5.99,8.9,;-7.32,8.13,;-1.99,6.59,;-1.99,8.13,;-.65,5.82,)|	InChI=1S/C29H38N4O3/c1-18(2)36-23-9-6-20(7-10-23)29(34)33-15-21-5-4-14-30-28(21)31-25-12-13-26(19(3)27(25)33)32-16-24-11-8-22(32)17-35-24/h4-5,12-14,18,20,22-24H,6-11,15-17H2,1-3H3,(H,30,31)	AXBZIQVMJPDJIP-UHFFFAOYSA-N	412568	US10399972, Example 59::(trans-4-isopropoxycyclohexyl){7-methyl-8-[(1S,4S)-2-oxa-5-azabicyclo[2.2.2]oct-5-yl]-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl}methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 58.7							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412568&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822597	CC(C)OC1CCC(CC1)C(=O)N1Cc2cccnc2Nc2cc(C)c(cc12)N1C[C@H]2CC[C@@H]1CO2 |r,wD:30.40,33.37,(6.54,2.79,;6.19,4.29,;7.32,5.34,;4.72,4.74,;3.59,3.7,;3.94,2.2,;2.81,1.15,;1.34,1.6,;.99,3.1,;2.12,4.15,;.21,.55,;-1.26,1.01,;.55,-.95,;2.05,-1.29,;2.72,-2.68,;4.25,-2.56,;5.12,-3.83,;4.45,-5.22,;2.92,-5.34,;2.05,-4.07,;.55,-4.41,;-.65,-3.45,;-1.99,-4.22,;-3.32,-3.45,;-4.66,-4.22,;-3.32,-1.91,;-1.99,-1.14,;-.65,-1.91,;-4.66,-1.14,;-5.99,-1.91,;-7.32,-1.14,;-5.82,-.9,;-6.2,.4,;-4.66,.4,;-5.99,1.17,;-7.32,.4,)|	InChI=1S/C29H38N4O3/c1-18(2)36-23-9-6-20(7-10-23)29(34)33-15-21-5-4-12-30-28(21)31-25-13-19(3)26(14-27(25)33)32-16-24-11-8-22(32)17-35-24/h4-5,12-14,18,20,22-24H,6-11,15-17H2,1-3H3,(H,30,31)	HDMHVZJYESAQHW-UHFFFAOYSA-N	412569	US10399972, Example 60::(trans-4-isopropoxycyclohexyl){9- methyl-8-[(1R,4R)-2-oxa-5- azabicyclo[2.2.2]oct-5-yl]-5,11- dihydro-6H-pyrido[2,3- b][1,5]benzodiazepin-6- yl}methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 25.9							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412569&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822598	CC(C)OC1CCC(CC1)C(=O)N1Cc2cccnc2Nc2ccc(N3C[C@H]4CC[C@@H]3CO4)c(C)c12 |r,wD:27.35,30.32,(6.54,2.79,;6.19,4.29,;7.32,5.34,;4.72,4.74,;3.59,3.7,;3.94,2.2,;2.81,1.15,;1.34,1.6,;.99,3.1,;2.12,4.15,;.21,.55,;-1.26,1.01,;.55,-.95,;2.05,-1.29,;2.72,-2.68,;4.25,-2.56,;5.12,-3.83,;4.45,-5.22,;2.92,-5.34,;2.05,-4.07,;.55,-4.41,;-.65,-3.45,;-1.99,-4.22,;-3.32,-3.45,;-3.32,-1.91,;-4.66,-1.14,;-5.99,-1.91,;-7.32,-1.14,;-5.82,-.9,;-6.2,.4,;-4.66,.4,;-5.99,1.17,;-7.32,.4,;-1.99,-1.14,;-2.39,.35,;-.65,-1.91,)|	InChI=1S/C29H38N4O3/c1-18(2)36-23-9-6-20(7-10-23)29(34)33-15-21-5-4-14-30-28(21)31-25-12-13-26(19(3)27(25)33)32-16-24-11-8-22(32)17-35-24/h4-5,12-14,18,20,22-24H,6-11,15-17H2,1-3H3,(H,30,31)	AXBZIQVMJPDJIP-UHFFFAOYSA-N	412570	US10399972, Example 61::(trans-4-isopropoxycyclohexyl){7- methyl-8-[(1R,4R)-2-oxa-5- azabicyclo[2.2.2]oct-5-yl]-5,11- dihydro-6H-pyrido[2,3- b][1,5]benzodiazepin-6- yl}methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 54.1							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412570&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822599	CC(C)O[C@H]1CC[C@@H](CC1)C(=O)N1Cc2cccnc2Nc2cc(F)c(cc12)N1CC2CCC1CO2 |r,wU:7.10,wD:4.3,(6.06,11.28,;5.29,12.61,;6.06,13.94,;3.75,12.61,;2.98,11.28,;1.44,11.28,;.67,9.94,;1.44,8.61,;2.98,8.61,;3.75,9.94,;.67,7.28,;-.87,7.28,;1.44,5.94,;2.98,5.94,;3.94,4.74,;5.41,5.19,;6.54,4.14,;6.2,2.64,;4.72,2.19,;3.59,3.24,;2.21,2.57,;.82,3.24,;-.31,2.19,;-1.78,2.64,;-2.91,1.6,;-2.12,4.14,;-.99,5.19,;.48,4.74,;-3.59,4.6,;-4.72,3.55,;-6.2,4.01,;-5.25,5.78,;-4.94,4.48,;-3.94,6.1,;-5.41,6.55,;-6.54,5.51,)|	InChI=1S/C28H35FN4O3/c1-17(2)36-21-8-5-18(6-9-21)28(34)33-14-19-4-3-11-30-27(19)31-24-12-23(29)25(13-26(24)33)32-15-22-10-7-20(32)16-35-22/h3-4,11-13,17-18,20-22H,5-10,14-16H2,1-2H3,(H,30,31)	FBQPUXUYYHTETQ-UHFFFAOYSA-N	412571	US10399972, Example 62::[9-fluoro-8-(2-oxa-5-azabicyclo[2.2.2]oct-5-yl)-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl](trans-4-isopropoxycyclohexyl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 35.2							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412571&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822600	CC(C)O[C@H]1CC[C@@H](CC1)C(=O)N1Cc2cccnc2Nc2ccc(N3CC4CCC3CO4)c(F)c12 |r,wU:7.10,wD:4.3,(6.06,11.28,;5.29,12.61,;6.06,13.94,;3.75,12.61,;2.98,11.28,;1.44,11.28,;.67,9.94,;1.44,8.61,;2.98,8.61,;3.75,9.94,;.67,7.28,;-.87,7.28,;1.44,5.94,;2.98,5.94,;3.94,4.74,;5.41,5.19,;6.54,4.14,;6.2,2.64,;4.72,2.19,;3.59,3.24,;2.21,2.57,;.82,3.24,;-.31,2.19,;-1.78,2.64,;-2.12,4.14,;-3.59,4.6,;-4.72,3.55,;-6.2,4.01,;-5.25,5.78,;-4.94,4.48,;-3.94,6.1,;-5.41,6.55,;-6.54,5.51,;-.99,5.19,;-1.34,6.69,;.48,4.74,)|	InChI=1S/C28H35FN4O3/c1-17(2)36-21-8-5-18(6-9-21)28(34)33-14-19-4-3-13-30-27(19)31-23-11-12-24(25(29)26(23)33)32-15-22-10-7-20(32)16-35-22/h3-4,11-13,17-18,20-22H,5-10,14-16H2,1-2H3,(H,30,31)	XYFUJTRBVLTSQZ-UHFFFAOYSA-N	412572	US10399972, Example 63::[7-fluoro-8-(2-oxa-5-azabicyclo[2.2.2]oct-5-yl)-5,11-dihydro-6H-pyrido[2,3-b][1,5]benzodiazepin-6-yl](trans-4-isopropoxycyclohexyl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 57.0							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412572&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822601	CC(C)O[C@H]1CC[C@@H](OC1)C(=O)N1Cc2cccnc2Nc2cc(F)c(cc12)N1C[C@@H]2C[C@H]1CO2 |r|	InChI=1S/C26H31FN4O4/c1-15(2)35-18-5-6-24(34-14-18)26(32)31-11-16-4-3-7-28-25(16)29-21-9-20(27)22(10-23(21)31)30-12-19-8-17(30)13-33-19/h3-4,7,9-10,15,17-19,24H,5-6,8,11-14H2,1-2H3,(H,28,29)	FRPMZDSJYBTKFE-UHFFFAOYSA-N	412573	US10399972, Example 64	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 46.3							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412573&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822602	CC(C)O[C@H]1CCC(CC1)C(=O)N1C(C)c2cccnc2Nc2ccc(Cl)cc12 |r,wU:4.3,(.56,5.29,;2.1,5.17,;2.97,6.45,;2.77,3.79,;1.9,2.51,;2.57,1.13,;1.7,-.15,;.17,-.03,;-.5,1.36,;.36,2.63,;-.7,-1.3,;-2.24,-1.19,;-.03,-2.69,;1.51,-2.69,;2.17,-1.3,;2.47,-3.9,;3.94,-3.44,;5.07,-4.49,;4.72,-5.99,;3.25,-6.45,;2.12,-5.4,;.74,-6.07,;-.65,-5.4,;-1.78,-6.45,;-3.25,-5.99,;-3.59,-4.49,;-5.07,-4.04,;-2.47,-3.44,;-.99,-3.9,)|	InChI=1S/C23H28ClN3O2/c1-14(2)29-18-9-6-16(7-10-18)23(28)27-15(3)19-5-4-12-25-22(19)26-20-11-8-17(24)13-21(20)27/h4-5,8,11-16,18H,6-7,9-10H2,1-3H3,(H,25,26)	OPLUIOYZCKWUHG-UHFFFAOYSA-N	412574	US10399972, Example 65	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 106							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412574	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412574&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822603	CC(C)O[C@H]1CC[C@@H](CC1)C(=O)N1C(C)c2cccnc2Nc2ccc(cc12)N1CCOCC1 |r,wU:4.3,wD:7.10,(4.44,6.45,;3.57,5.17,;2.04,5.29,;4.24,3.79,;3.37,2.51,;4.04,1.13,;3.17,-.15,;1.64,-.03,;.97,1.36,;1.84,2.63,;.77,-1.3,;-.77,-1.19,;1.44,-2.69,;2.98,-2.69,;3.65,-1.3,;3.94,-3.9,;5.41,-3.44,;6.54,-4.49,;6.2,-5.99,;4.72,-6.45,;3.59,-5.4,;2.21,-6.07,;.82,-5.4,;-.31,-6.45,;-1.78,-5.99,;-2.12,-4.49,;-.99,-3.44,;.48,-3.9,;-3.59,-4.04,;-3.94,-2.53,;-5.41,-2.08,;-6.54,-3.13,;-6.2,-4.63,;-4.72,-5.08,)|	InChI=1S/C27H36N4O3/c1-18(2)34-22-9-6-20(7-10-22)27(32)31-19(3)23-5-4-12-28-26(23)29-24-11-8-21(17-25(24)31)30-13-15-33-16-14-30/h4-5,8,11-12,17-20,22H,6-7,9-10,13-16H2,1-3H3,(H,28,29)	SCXFGKLXTUHSMT-UHFFFAOYSA-N	412575	US10399972, Example 66	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 71.9							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412575&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822604	COc1ccc2Nc3ncccc3C(C)N(C(=O)C3CCN(CC(F)(F)F)CC3)c2c1	InChI=1S/C22H25F3N4O2/c1-14-17-4-3-9-26-20(17)27-18-6-5-16(31-2)12-19(18)29(14)21(30)15-7-10-28(11-8-15)13-22(23,24)25/h3-6,9,12,14-15H,7-8,10-11,13H2,1-2H3,(H,26,27)	IAMWUSJCSWQJTC-UHFFFAOYSA-N	412576	US10399972, Example 67	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 215							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412576	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412576&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822605	COc1ccc2Nc3ncccc3C(C)N(C(=O)[C@H]3CC[C@@H](CC3)OC(C)C)c2c1 |r,wU:21.25,wD:18.18,(-5.63,-5.08,;-4.5,-4.04,;-3.03,-4.49,;-2.69,-5.99,;-1.22,-6.45,;-.09,-5.4,;1.3,-6.07,;2.69,-5.4,;3.82,-6.45,;5.29,-5.99,;5.63,-4.49,;4.5,-3.44,;3.03,-3.9,;2.07,-2.69,;2.74,-1.3,;.53,-2.69,;-.14,-1.3,;-1.67,-1.19,;.73,-.03,;2.27,-.15,;3.13,1.13,;2.46,2.51,;.93,2.63,;.06,1.36,;3.33,3.79,;2.66,5.17,;3.53,6.45,;1.13,5.29,;-.43,-3.9,;-1.9,-3.44,)|	InChI=1S/C24H31N3O3/c1-15(2)30-18-9-7-17(8-10-18)24(28)27-16(3)20-6-5-13-25-23(20)26-21-12-11-19(29-4)14-22(21)27/h5-6,11-18H,7-10H2,1-4H3,(H,25,26)	DFJLVRJALPMFFI-UHFFFAOYSA-N	412577	US10399972, Example 68	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 112							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412577	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412577&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822606	CC(C)O[C@H]1CCC(CC1)C(=O)N1Cc2cc(C)cnc2Nc2ccc(cc12)N1C[C@@H]2CC[C@H]1CO2 |r,wU:30.40,33.37,wD:4.3,(7.32,5.34,;6.19,4.29,;6.54,2.79,;4.72,4.74,;3.59,3.7,;2.12,4.15,;.99,3.1,;1.34,1.6,;2.81,1.15,;3.94,2.2,;.21,.55,;-1.26,1.01,;.55,-.95,;2.05,-1.29,;2.72,-2.68,;4.25,-2.56,;5.12,-3.83,;6.66,-3.72,;4.45,-5.22,;2.92,-5.34,;2.05,-4.07,;.55,-4.41,;-.65,-3.45,;-1.99,-4.22,;-3.32,-3.45,;-3.32,-1.91,;-1.99,-1.14,;-.65,-1.91,;-4.66,-1.14,;-5.99,-1.91,;-7.32,-1.14,;-5.8,-1.09,;-6.2,.4,;-4.66,.4,;-5.99,1.17,;-7.32,.4,)|	InChI=1S/C29H38N4O3/c1-18(2)36-24-8-4-20(5-9-24)29(34)33-15-21-12-19(3)14-30-28(21)31-26-11-7-22(13-27(26)33)32-16-25-10-6-23(32)17-35-25/h7,11-14,18,20,23-25H,4-6,8-10,15-17H2,1-3H3,(H,30,31)	IMTQUGOIFSTEJD-UHFFFAOYSA-N	412578	US10399972, Example 69	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 103							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412578	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412578&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822607	CC(C)O[C@H]1CCC(CC1)C(=O)N1Cc2cc(cnc2Nc2ccc(cc12)N1C[C@@H]2CC[C@H]1CO2)S(C)(=O)=O |r,wU:29.39,32.36,wD:4.3,(6.89,5.34,;5.76,4.29,;6.1,2.79,;4.29,4.74,;3.16,3.7,;1.69,4.15,;.56,3.1,;.9,1.6,;2.37,1.15,;3.5,2.2,;-.23,.55,;-1.7,1.01,;.11,-.95,;1.62,-1.29,;2.28,-2.68,;3.82,-2.56,;4.69,-3.83,;4.02,-5.22,;2.48,-5.34,;1.62,-4.07,;.11,-4.41,;-1.09,-3.45,;-2.42,-4.22,;-3.76,-3.45,;-3.76,-1.91,;-2.42,-1.14,;-1.09,-1.91,;-5.09,-1.14,;-6.42,-1.91,;-7.76,-1.14,;-6.23,-1.09,;-6.63,.4,;-5.09,.4,;-6.42,1.17,;-7.76,.4,;6.22,-3.72,;6.34,-5.26,;7.76,-3.6,;6.11,-2.18,)|	InChI=1S/C29H38N4O5S/c1-18(2)38-23-8-4-19(5-9-23)29(34)33-15-20-12-25(39(3,35)36)14-30-28(20)31-26-11-7-21(13-27(26)33)32-16-24-10-6-22(32)17-37-24/h7,11-14,18-19,22-24H,4-6,8-10,15-17H2,1-3H3,(H,30,31)	SXAQTJPWGFWVIQ-UHFFFAOYSA-N	412579	US10399972, Example 70	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 5745							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412579	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412579&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822608	CC(C)O[C@H]1CCC(CC1)C(=O)N1Cc2cc(Cl)cnc2Nc2ccc(cc12)N1C[C@@H]2CC[C@H]1CO2 |r,wU:30.40,33.37,wD:4.3,(7.32,5.34,;6.19,4.29,;6.54,2.79,;4.72,4.74,;3.59,3.7,;2.12,4.15,;.99,3.1,;1.34,1.6,;2.81,1.15,;3.94,2.2,;.21,.55,;-1.26,1.01,;.55,-.95,;2.05,-1.29,;2.72,-2.68,;4.25,-2.56,;5.12,-3.83,;6.66,-3.72,;4.45,-5.22,;2.92,-5.34,;2.05,-4.07,;.55,-4.41,;-.65,-3.45,;-1.99,-4.22,;-3.32,-3.45,;-3.32,-1.91,;-1.99,-1.14,;-.65,-1.91,;-4.66,-1.14,;-5.99,-1.91,;-7.32,-1.14,;-5.8,-1.09,;-6.2,.4,;-4.66,.4,;-5.99,1.17,;-7.32,.4,)|	InChI=1S/C28H35ClN4O3/c1-17(2)36-23-7-3-18(4-8-23)28(34)33-14-19-11-20(29)13-30-27(19)31-25-10-6-21(12-26(25)33)32-15-24-9-5-22(32)16-35-24/h6,10-13,17-18,22-24H,3-5,7-9,14-16H2,1-2H3,(H,30,31)	MWCWTOAPMNWRBE-UHFFFAOYSA-N	412580	US10399972, Example 71	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412580	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412580&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822609	Fc1ccc2N(Cc3cc(F)cnc3Nc2c1)C(=O)C1CCN(CC(F)(F)F)CC1	InChI=1S/C20H19F5N4O/c21-14-1-2-17-16(8-14)27-18-13(7-15(22)9-26-18)10-29(17)19(30)12-3-5-28(6-4-12)11-20(23,24)25/h1-2,7-9,12H,3-6,10-11H2,(H,26,27)	VCDHIULWIHQKRC-UHFFFAOYSA-N	412581	US10399972, Example 72::(3,9-Difluoro-5,11-dihydro-6H-benzo[b]pyrido[2,3-e][1,4]diazepin-6-yl)(1-(2,2,2-trifluoroethyl)piperidin-4-yl)methanone	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 160							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412581	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412581&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822610	Fc1cnc2Nc3cc(F)c(cc3N(Cc2c1)C(=O)C1CCN(CC(F)(F)F)CC1)N1CC2CCC1CO2	InChI=1S/C26H28F5N5O2/c27-17-7-16-11-36(25(37)15-3-5-34(6-4-15)14-26(29,30)31)23-9-22(35-12-19-2-1-18(35)13-38-19)20(28)8-21(23)33-24(16)32-10-17/h7-10,15,18-19H,1-6,11-14H2,(H,32,33)	JAYSMAUSONUIDZ-UHFFFAOYSA-N	412538	US10399972, Example 73::(8-(2-oxa-5- azabicyclo[2.2.2]octan-5-yl)-3,9- difluoro-5,11-dihydro-6H- benzo[b]pyrido[2,3- e][1,4]diazepin-6-yl)(1-(2,2,2- trifluoroethyl)piperidin-4- yl)methanone::US10399972, Example 29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412538&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
822611	Fc1ccc2N(Cc3cccnc3Nc2c1)C(=O)C1CCN(CC(F)(F)F)CC1	InChI=1S/C20H20F4N4O/c21-15-3-4-17-16(10-15)26-18-14(2-1-7-25-18)11-28(17)19(29)13-5-8-27(9-6-13)12-20(22,23)24/h1-4,7,10,13H,5-6,8-9,11-12H2,(H,25,26)	ARZREWANQFTWTJ-UHFFFAOYSA-N	412583	US10399972, Example 74	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 174							US Patent		10.7270/Q2TH8Q2V		aid1803795	US10399972	Witter, DJ; Biftu, T; Biju, P; Bogen, SL; Hong, Q; Huang, C; Huang, X; Li, B; Park, MK; Sloman, DL	9/3/2019	7/27/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=412583	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=412583&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824790	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CO)ccc12 |r|	InChI=1S/C24H28F3N3O2/c1-15-10-18(13-23(2,3)12-15)30-21-9-4-16(14-31)11-20(21)29-22(30)28-17-5-7-19(8-6-17)32-24(25,26)27/h4-9,11,15,18,31H,10,12-14H2,1-3H3,(H,28,29)	ASTCXLYWPLXJTC-UHFFFAOYSA-N	413477	(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)methanol, enantiomer A::US10414734, Example 2-1-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 50.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413477	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413477&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824791	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CO)ccc12 |r|	InChI=1S/C24H28F3N3O2/c1-15-10-18(13-23(2,3)12-15)30-21-9-4-16(14-31)11-20(21)29-22(30)28-17-5-7-19(8-6-17)32-24(25,26)27/h4-9,11,15,18,31H,10,12-14H2,1-3H3,(H,28,29)	ASTCXLYWPLXJTC-UHFFFAOYSA-N	413478	(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)methanol, enantiomer B::US10414734, Example 2-1-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 70.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413478&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824792	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(C)(C)O |r|	InChI=1S/C26H32F3N3O2/c1-16-12-19(15-24(2,3)14-16)32-22-11-6-17(25(4,5)33)13-21(22)31-23(32)30-18-7-9-20(10-8-18)34-26(27,28)29/h6-11,13,16,19,33H,12,14-15H2,1-5H3,(H,30,31)	BHWYRUKPELASRE-UHFFFAOYSA-N	413479	2-(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propan-2-ol, enantiomer B::US10414734, Example 2-2-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413479	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413479&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824793	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(c(C)cc12)C(C)(C)O |r|	InChI=1S/C27H34F3N3O2/c1-16-11-19(15-25(3,4)14-16)33-23-12-17(2)21(26(5,6)34)13-22(23)32-24(33)31-18-7-9-20(10-8-18)35-27(28,29)30/h7-10,12-13,16,19,34H,11,14-15H2,1-6H3,(H,31,32)	LHRMRXMFGPVSRX-UHFFFAOYSA-N	413480	2-(6-methyl-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propan-2-ol, enantiomer A::US10414734, Example 2-3-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413480	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413480&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824794	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(c(C)cc12)C(C)(C)O |r|	InChI=1S/C27H34F3N3O2/c1-16-11-19(15-25(3,4)14-16)33-23-12-17(2)21(26(5,6)34)13-22(23)32-24(33)31-18-7-9-20(10-8-18)35-27(28,29)30/h7-10,12-13,16,19,34H,11,14-15H2,1-6H3,(H,31,32)	LHRMRXMFGPVSRX-UHFFFAOYSA-N	413481	2-(6-methyl-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propan-2-ol, enantiomer B::US10414734, Example 2-3-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413481&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824795	Cc1cc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C(C)(C)O	InChI=1S/C28H36F3N3O2/c1-17-12-23-22(13-21(17)27(6,7)35)33-24(32-18-8-10-20(11-9-18)36-28(29,30)31)34(23)19-14-25(2,3)16-26(4,5)15-19/h8-13,19,35H,14-16H2,1-7H3,(H,32,33)	DJHWCMGNXAMDJB-UHFFFAOYSA-N	413482	2-[6-methyl-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazol-5-yl]propan-2-ol::US10414734, Example 2-4	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413482	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413482&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824796	Cc1cc2n(C3CC(C)(C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1[C@@H](O)C(F)(F)F |r|	InChI=1S/C27H31F6N3O2/c1-15-10-21-20(11-19(15)22(37)26(28,29)30)35-23(34-16-6-8-18(9-7-16)38-27(31,32)33)36(21)17-12-24(2,3)14-25(4,5)13-17/h6-11,17,22,37H,12-14H2,1-5H3,(H,34,35)	VKILRZNXGLUIOW-UHFFFAOYSA-N	413484	2,2,2-trifluoro-1-[6-methyl-1-(3,3,5,5-tetramethylcyclohexyl)-2-{[4-(trifluoromethoxy)phenyl]amino}-1H-benzimidazol-5-yl]ethanol::US10414734, Example 2-5	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413484&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824797	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1CO |r|	InChI=1S/C25H30F3N3O3/c1-15-9-18(13-24(2,3)12-15)31-21-11-22(33-4)16(14-32)10-20(21)30-23(31)29-17-5-7-19(8-6-17)34-25(26,27)28/h5-8,10-11,15,18,32H,9,12-14H2,1-4H3,(H,29,30)	HETZGNBFHGFYPX-UHFFFAOYSA-N	413485	(6-methoxy-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)methanol::US10414734, Example 2-6-1::US10414734, Example 2-6	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413485&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824798	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1CO |r|	InChI=1S/C25H30F3N3O3/c1-15-9-18(13-24(2,3)12-15)31-21-11-22(33-4)16(14-32)10-20(21)30-23(31)29-17-5-7-19(8-6-17)34-25(26,27)28/h5-8,10-11,15,18,32H,9,12-14H2,1-4H3,(H,29,30)	HETZGNBFHGFYPX-UHFFFAOYSA-N	413485	(6-methoxy-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)methanol::US10414734, Example 2-6-1::US10414734, Example 2-6	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413485&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824799	COc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1CO |r|	InChI=1S/C25H30F3N3O3/c1-15-9-18(13-24(2,3)12-15)31-21-11-22(33-4)16(14-32)10-20(21)30-23(31)29-17-5-7-19(8-6-17)34-25(26,27)28/h5-8,10-11,15,18,32H,9,12-14H2,1-4H3,(H,29,30)	HETZGNBFHGFYPX-UHFFFAOYSA-N	413488	(6-methoxy-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)methanol, enantiomer B::US10414734, Example 2-6-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 110							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413488&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824800	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C(C)(C)O |r|	InChI=1S/C27H34F3N3O3/c1-16-11-18(15-25(2,3)14-16)33-22-13-23(35-6)20(26(4,5)34)12-21(22)32-24(33)31-17-7-9-19(10-8-17)36-27(28,29)30/h7-10,12-13,16,18,34H,11,14-15H2,1-6H3,(H,31,32)	VNPYHCWSVKJJKN-UHFFFAOYSA-N	413489	US10414734, Example 2-7-1::2-(6-methoxy-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propan-2-ol::US10414734, Example 2-7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413489&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824801	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C(C)(C)O |r|	InChI=1S/C27H34F3N3O3/c1-16-11-18(15-25(2,3)14-16)33-22-13-23(35-6)20(26(4,5)34)12-21(22)32-24(33)31-17-7-9-19(10-8-17)36-27(28,29)30/h7-10,12-13,16,18,34H,11,14-15H2,1-6H3,(H,31,32)	VNPYHCWSVKJJKN-UHFFFAOYSA-N	413489	US10414734, Example 2-7-1::2-(6-methoxy-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propan-2-ol::US10414734, Example 2-7	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 50.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413489&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824802	COc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1C(C)(C)O |r|	InChI=1S/C27H34F3N3O3/c1-16-11-18(15-25(2,3)14-16)33-22-13-23(35-6)20(26(4,5)34)12-21(22)32-24(33)31-17-7-9-19(10-8-17)36-27(28,29)30/h7-10,12-13,16,18,34H,11,14-15H2,1-6H3,(H,31,32)	VNPYHCWSVKJJKN-UHFFFAOYSA-N	413491	2-(6-methoxy-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propan-2-ol, enantiomer B::US10414734, Example 2-7-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413491	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413491&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824803	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CC(C)(C)O)c(C)cc12 |r|	InChI=1S/C28H36F3N3O2/c1-17-11-21(16-26(3,4)14-17)34-24-12-18(2)19(15-27(5,6)35)13-23(24)33-25(34)32-20-7-9-22(10-8-20)36-28(29,30)31/h7-10,12-13,17,21,35H,11,14-16H2,1-6H3,(H,32,33)	ACSIARXTMAEMTK-UHFFFAOYSA-N	413492	US10414734, Example 2-8-1::US10414734, Example 2-8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413492&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824804	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CC(C)(C)O)c(C)cc12 |r|	InChI=1S/C28H36F3N3O2/c1-17-11-21(16-26(3,4)14-17)34-24-12-18(2)19(15-27(5,6)35)13-23(24)33-25(34)32-20-7-9-22(10-8-20)36-28(29,30)31/h7-10,12-13,17,21,35H,11,14-16H2,1-6H3,(H,32,33)	ACSIARXTMAEMTK-UHFFFAOYSA-N	413492	US10414734, Example 2-8-1::US10414734, Example 2-8	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 120							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413492&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824805	C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CC(C)(C)O)c(C)cc12 |r|	InChI=1S/C28H36F3N3O2/c1-17-11-21(16-26(3,4)14-17)34-24-12-18(2)19(15-27(5,6)35)13-23(24)33-25(34)32-20-7-9-22(10-8-20)36-28(29,30)31/h7-10,12-13,17,21,35H,11,14-16H2,1-6H3,(H,32,33)	ACSIARXTMAEMTK-UHFFFAOYSA-N	413494	US10414734, Example 2-8-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413494	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413494&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824806	COc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1CC(C)(C)O |r|	InChI=1S/C28H36F3N3O3/c1-17-11-20(16-26(2,3)14-17)34-23-13-24(36-6)18(15-27(4,5)35)12-22(23)33-25(34)32-19-7-9-21(10-8-19)37-28(29,30)31/h7-10,12-13,17,20,35H,11,14-16H2,1-6H3,(H,32,33)	GTTQUIYOBKTHGV-UHFFFAOYSA-N	413495	US10414734, Example 2-9-1::US10414734, Example 2-9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 20.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413495&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824807	COc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1CC(C)(C)O |r|	InChI=1S/C28H36F3N3O3/c1-17-11-20(16-26(2,3)14-17)34-23-13-24(36-6)18(15-27(4,5)35)12-22(23)33-25(34)32-19-7-9-21(10-8-19)37-28(29,30)31/h7-10,12-13,17,20,35H,11,14-16H2,1-6H3,(H,32,33)	GTTQUIYOBKTHGV-UHFFFAOYSA-N	413495	US10414734, Example 2-9-1::US10414734, Example 2-9	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 30.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413495&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824808	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1CC(C)(C)O |r|	InChI=1S/C28H36F3N3O3/c1-17-11-20(16-26(2,3)14-17)34-23-13-24(36-6)18(15-27(4,5)35)12-22(23)33-25(34)32-19-7-9-21(10-8-19)37-28(29,30)31/h7-10,12-13,17,20,35H,11,14-16H2,1-6H3,(H,32,33)	GTTQUIYOBKTHGV-UHFFFAOYSA-N	413497	US10414734, Example 2-9-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413497	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413497&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824809	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CC(C)(C)O)c(F)cc12 |r|	InChI=1S/C27H33F4N3O2/c1-16-10-19(15-25(2,3)13-16)34-23-12-21(28)17(14-26(4,5)35)11-22(23)33-24(34)32-18-6-8-20(9-7-18)36-27(29,30)31/h6-9,11-12,16,19,35H,10,13-15H2,1-5H3,(H,32,33)	WJXOBWXHAIJSIH-UHFFFAOYSA-N	413498	US10414734, Example 2-10-1::US10414734, Example 2-10	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 240							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413498	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413498&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824810	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CC(C)(C)O)c(F)cc12 |r|	InChI=1S/C27H33F4N3O2/c1-16-10-19(15-25(2,3)13-16)34-23-12-21(28)17(14-26(4,5)35)11-22(23)33-24(34)32-18-6-8-20(9-7-18)36-27(29,30)31/h6-9,11-12,16,19,35H,10,13-15H2,1-5H3,(H,32,33)	WJXOBWXHAIJSIH-UHFFFAOYSA-N	413498	US10414734, Example 2-10-1::US10414734, Example 2-10	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 320							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413498	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413498&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824811	C[C@H]1C[C@H](CC(C)(C)C1)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(C)(C)O)ccc12 |r|	InChI=1S/C28H36F3N3O2/c1-18-14-21(17-26(2,3)16-18)34-24-11-6-19(12-13-27(4,5)35)15-23(24)33-25(34)32-20-7-9-22(10-8-20)36-28(29,30)31/h6-11,15,18,21,35H,12-14,16-17H2,1-5H3,(H,32,33)	BIYCJLSJTVGOOP-UHFFFAOYSA-N	413500	2-methyl-4-(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)butan-2-ol, enantiomer A::US10414734, Example 2-11-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 210							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413500	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413500&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824812	COc1cc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1CCC(C)(C)O |r|	InChI=1S/C29H38F3N3O3/c1-18-13-21(17-27(2,3)16-18)35-24-15-25(37-6)19(11-12-28(4,5)36)14-23(24)34-26(35)33-20-7-9-22(10-8-20)38-29(30,31)32/h7-10,14-15,18,21,36H,11-13,16-17H2,1-6H3,(H,33,34)	XFBMKIZUTVSKPT-UHFFFAOYSA-N	413501	4-(6-methoxy-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)-2-methylbutan-2-ol, enantiomer A::US10414734, Example 2-12-1	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 50.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413501	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413501&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824813	COc1cc2n([C@H]3C[C@@H](C)CC(C)(C)C3)c(Nc3ccc(OC(F)(F)F)cc3)nc2cc1CCC(C)(C)O |r|	InChI=1S/C29H38F3N3O3/c1-18-13-21(17-27(2,3)16-18)35-24-15-25(37-6)19(11-12-28(4,5)36)14-23(24)34-26(35)33-20-7-9-22(10-8-20)38-29(30,31)32/h7-10,14-15,18,21,36H,11-13,16-17H2,1-6H3,(H,33,34)	XFBMKIZUTVSKPT-UHFFFAOYSA-N	413502	4-(6-methoxy-2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)-2-methylbutan-2-ol, enantiomer B::US10414734, Example 2-12-2	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 10.00							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413502	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413502&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824814	CC(C)[C@@H]1CC[C@@H](C)C[C@H]1n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C(C)(C)O |r|	InChI=1S/C27H34F3N3O2/c1-16(2)21-12-6-17(3)14-24(21)33-23-13-7-18(26(4,5)34)15-22(23)32-25(33)31-19-8-10-20(11-9-19)35-27(28,29)30/h7-11,13,15-17,21,24,34H,6,12,14H2,1-5H3,(H,31,32)	KRRUEQHLDOVUAY-UHFFFAOYSA-N	413504	2-(1-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl]-2-{[4-(trifluoromethoxy)phenyl]-amino}-1H-benzimidazol-5-yl)propan-2-ol::US10414734, Example 2-13	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 80.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413504	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413504&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824815	CC(C)[C@@H]1CC[C@@H](C)C[C@H]1n1c(Nc2ccc(cc2)C(C)C)nc2cc(ccc12)C(C)(C)O |r|	InChI=1S/C29H41N3O/c1-18(2)21-9-12-23(13-10-21)30-28-31-25-17-22(29(6,7)33)11-15-26(25)32(28)27-16-20(5)8-14-24(27)19(3)4/h9-13,15,17-20,24,27,33H,8,14,16H2,1-7H3,(H,30,31)	LPTDIMLNIOGGDQ-UHFFFAOYSA-N	413505	US10414734, Example 2-14	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 120							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413505	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413505&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824816	CC(C)[C@@H]1CC[C@@H](C)C[C@H]1n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CC(C)(C)O)ccc12 |r|	InChI=1S/C28H36F3N3O2/c1-17(2)22-12-6-18(3)14-25(22)34-24-13-7-19(16-27(4,5)35)15-23(24)33-26(34)32-20-8-10-21(11-9-20)36-28(29,30)31/h7-11,13,15,17-18,22,25,35H,6,12,14,16H2,1-5H3,(H,32,33)	QSQNYSXGSINRCT-UHFFFAOYSA-N	413506	US10414734, Example 2-15	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 40.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413506	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413506&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824817	CC(C)[C@@H]1CC[C@@H](C)C[C@H]1n1c(Nc2ccc(cc2)C(C)C)nc2cc(CC(C)(C)O)ccc12 |r|	InChI=1S/C30H43N3O/c1-19(2)23-10-12-24(13-11-23)31-29-32-26-17-22(18-30(6,7)34)9-15-27(26)33(29)28-16-21(5)8-14-25(28)20(3)4/h9-13,15,17,19-21,25,28,34H,8,14,16,18H2,1-7H3,(H,31,32)	SXUSTENSLCDHFO-UHFFFAOYSA-N	413507	US10414734, Example 2-16	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 60.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413507	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413507&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824818	CC(C)Oc1ccc(Nc2nc3cc(CC(C)(C)O)ccc3n2[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1 |r|	InChI=1S/C30H43N3O2/c1-19(2)25-14-8-21(5)16-28(25)33-27-15-9-22(18-30(6,7)34)17-26(27)32-29(33)31-23-10-12-24(13-11-23)35-20(3)4/h9-13,15,17,19-21,25,28,34H,8,14,16,18H2,1-7H3,(H,31,32)	PMXHSYWTWNVSDF-UHFFFAOYSA-N	413508	US10414734, Example 2-17	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 160							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413508	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413508&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824819	CC(C)[C@@H]1CC[C@@H](C)C[C@H]1n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(C)(C)O)ccc12 |r|	InChI=1S/C29H38F3N3O2/c1-18(2)23-12-6-19(3)16-26(23)35-25-13-7-20(14-15-28(4,5)36)17-24(25)34-27(35)33-21-8-10-22(11-9-21)37-29(30,31)32/h7-11,13,17-19,23,26,36H,6,12,14-16H2,1-5H3,(H,33,34)	PQAXCBVGSULMKJ-UHFFFAOYSA-N	413509	US10414734, Example 2-18	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 100.0							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413509&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824820	CC(C)[C@@H]1CC[C@@H](C)C[C@H]1n1c(Nc2ccc(cc2)C(C)C)nc2cc(CCC(C)(C)O)ccc12 |r|	InChI=1S/C31H45N3O/c1-20(2)24-10-12-25(13-11-24)32-30-33-27-19-23(16-17-31(6,7)35)9-15-28(27)34(30)29-18-22(5)8-14-26(29)21(3)4/h9-13,15,19-22,26,29,35H,8,14,16-18H2,1-7H3,(H,32,33)	JPSSWXCZWRFZCN-UHFFFAOYSA-N	413510	US10414734, Example 2-19	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 290							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413510	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413510&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
824821	CC(C)Oc1ccc(Nc2nc3cc(CCC(C)(C)O)ccc3n2[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1 |r|	InChI=1S/C31H45N3O2/c1-20(2)26-14-8-22(5)18-29(26)34-28-15-9-23(16-17-31(6,7)35)19-27(28)33-30(34)32-24-10-12-25(13-11-24)36-21(3)4/h9-13,15,19-22,26,29,35H,8,14,16-18H2,1-7H3,(H,32,33)	DMPBHYMQWMIWIS-UHFFFAOYSA-N	413511	US10414734, Example 2-20	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 300							US Patent		10.7270/Q2028TXC		aid1803821	US10414734	Panknin, O; Ring, S; Zimmermann, K; Neuhaus, R	9/17/2019	8/2/2020	Bayer Pharma Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=413511	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=413511&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search											1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
834529	CO[C@H]1CC[C@@H](CC1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)-c1cn[nH]c1 |r,wU:2.1,wD:5.8,(2.76,5.88,;3.53,4.54,;2.76,3.21,;3.53,1.88,;2.76,.54,;1.22,.54,;.45,1.88,;1.22,3.21,;.45,-.79,;-1.09,-.79,;1.22,-2.12,;2.76,-2.12,;3.72,-3.33,;5.19,-2.87,;6.32,-3.92,;5.98,-5.42,;4.51,-5.88,;3.38,-4.83,;1.99,-5.5,;.6,-4.83,;-.53,-5.88,;-2,-5.42,;-2.34,-3.92,;-1.21,-2.87,;.26,-3.33,;-3.83,-3.52,;-4.3,-2.06,;-5.84,-2.06,;-6.32,-3.52,;-5.07,-4.43,)|	InChI=1S/C23H25N5O2/c1-30-19-7-4-15(5-8-19)23(29)28-14-17-3-2-10-24-22(17)27-20-9-6-16(11-21(20)28)18-12-25-26-13-18/h2-3,6,9-13,15,19H,4-5,7-8,14H2,1H3,(H,24,27)(H,25,26)	ICEZNJFBUJCPFU-UHFFFAOYSA-N	416213	6-[(trans-4- methoxycyclohexyl)carbonyl]- 8-(1H-pyrazol-4-yl)-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10442819, Example 357	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 107							US Patent		10.7270/Q2HQ428F		aid1803896	US10442819	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Ellis, JM; Esposite, S; Hong, Q; Huang, C; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Otte, RD; Parker, Jr., DL; Reutershan, M; Sciammetta, N; Shao, PP; Sloman, DL; Ujjainwalla, F; White, C; Wu, Z; Yu, Y; Zhao, K; Gibeau, C; Biftu, T; Biju, P; Chen, L; Close, J; Fuller, PH; Huang, X; Park, MK; Simov, V; Witter, DJ; Zhang, H	10/15/2019	8/24/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=416213	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=416213&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			121389863	433916174							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
834581	CO[C@H]1CC[C@@H](CC1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)-c1cnc2cc[nH]c2c1 |r,wU:2.1,wD:5.8,(4.03,5.88,;4.8,4.54,;4.03,3.21,;4.8,1.88,;4.03,.54,;2.49,.54,;1.72,1.88,;2.49,3.21,;1.72,-.79,;.18,-.79,;2.49,-2.12,;4.03,-2.12,;4.99,-3.33,;6.46,-2.87,;7.59,-3.92,;7.25,-5.42,;5.78,-5.88,;4.65,-4.83,;3.26,-5.5,;1.88,-4.83,;.75,-5.88,;-.72,-5.42,;-1.07,-3.92,;.06,-2.87,;1.53,-3.33,;-2.57,-3.56,;-3.04,-2.09,;-4.55,-1.77,;-5.58,-2.92,;-7.12,-2.92,;-7.59,-4.38,;-6.35,-5.29,;-5.1,-4.38,;-3.6,-4.7,)|	InChI=1S/C27H27N5O2/c1-34-21-7-4-17(5-8-21)27(33)32-16-19-3-2-11-29-26(19)31-23-9-6-18(14-25(23)32)20-13-24-22(30-15-20)10-12-28-24/h2-3,6,9-15,17,21,28H,4-5,7-8,16H2,1H3,(H,29,31)	OHDIIJGGHXRCSY-UHFFFAOYSA-N	416265	6-[(trans-4- methoxycyclohexyl)carbonyl]-8-(1H- pyrrolo[3,2-b]pyridin-6-yl)-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10442819, Example 409	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 44.0							US Patent		10.7270/Q2HQ428F		aid1803896	US10442819	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Ellis, JM; Esposite, S; Hong, Q; Huang, C; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Otte, RD; Parker, Jr., DL; Reutershan, M; Sciammetta, N; Shao, PP; Sloman, DL; Ujjainwalla, F; White, C; Wu, Z; Yu, Y; Zhao, K; Gibeau, C; Biftu, T; Biju, P; Chen, L; Close, J; Fuller, PH; Huang, X; Park, MK; Simov, V; Witter, DJ; Zhang, H	10/15/2019	8/24/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=416265	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=416265&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132255469	433916221							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
834582	CO[C@H]1CC[C@@H](CC1)C(=O)N1Cc2cccnc2Nc2ccc(cc12)-c1ccnc2[nH]ccc12 |r,wU:2.1,wD:5.8,(3,5.88,;3.77,4.54,;3,3.21,;3.77,1.88,;3,.54,;1.46,.54,;.69,1.88,;1.46,3.21,;.69,-.79,;-.85,-.79,;1.46,-2.12,;3,-2.12,;3.96,-3.33,;5.43,-2.87,;6.56,-3.92,;6.22,-5.42,;4.75,-5.88,;3.62,-4.83,;2.23,-5.5,;.84,-4.83,;-.29,-5.88,;-1.76,-5.42,;-2.1,-3.92,;-.97,-2.87,;.5,-3.33,;-3.63,-3.54,;-4.78,-4.57,;-6.24,-4.1,;-6.56,-2.59,;-5.42,-1.56,;-5.42,-.02,;-3.95,.46,;-3.05,-.79,;-3.95,-2.03,)|	InChI=1S/C27H27N5O2/c1-34-20-7-4-17(5-8-20)27(33)32-16-19-3-2-12-28-25(19)31-23-9-6-18(15-24(23)32)21-10-13-29-26-22(21)11-14-30-26/h2-3,6,9-15,17,20H,4-5,7-8,16H2,1H3,(H,28,31)(H,29,30)	IZTOUWVQNNTWHF-UHFFFAOYSA-N	416266	6-[(trans-4- methoxycyclohexyl)carbonyl]-8-(1H- pyrrolo[2,3-b]pyridin-4-yl)-6,11- dihydro-5H-pyrido[2,3- b][1,5]benzodiazepine::US10442819, Example 410	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 31.0							US Patent		10.7270/Q2HQ428F		aid1803896	US10442819	Fischer, C; Bogen, SL; Childers, ML; Fradera Llinas, FX; Ellis, JM; Esposite, S; Hong, Q; Huang, C; Kim, AJ; Lampe, JW; Machacek, MR; McMasters, DR; Otte, RD; Parker, Jr., DL; Reutershan, M; Sciammetta, N; Shao, PP; Sloman, DL; Ujjainwalla, F; White, C; Wu, Z; Yu, Y; Zhao, K; Gibeau, C; Biftu, T; Biju, P; Chen, L; Close, J; Fuller, PH; Huang, X; Park, MK; Simov, V; Witter, DJ; Zhang, H	10/15/2019	8/24/2020	Merck Sharp & Dohme	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=416266	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=416266&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			132255412	433916222							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
870497	C[C@H](Nc1nccc(n1)-n1cnc(C)c1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C20H19ClN6O/c1-11-13(3)27(10-23-11)18-6-7-22-20(26-18)24-12(2)16-9-14-8-15(21)4-5-17(14)25-19(16)28/h4-10,12H,1-3H3,(H,25,28)(H,22,24,26)	JWQDURYVKXPHNG-UHFFFAOYSA-N	429845	US10550099, Compound I-53	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2HT2RR8		aid1804139	US10550099	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	2/4/2020	11/7/2020	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=429845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=429845&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			154732820	434319302							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
870540	C[C@H](Nc1nccc(n1)-c1cn[nH]c1C)c1cc2cc(Cl)ccc2[nH]c1=O |r|	InChI=1S/C19H17ClN6O/c1-10(14-8-12-7-13(20)3-4-16(12)24-18(14)27)23-19-21-6-5-17(25-19)15-9-22-26-11(15)2/h3-10H,1-2H3,(H,22,26)(H,24,27)(H,21,23,25)	HHLWJRDHYWCEIY-UHFFFAOYSA-N	429875	US10550099, Compound I-83	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2HT2RR8		aid1804139	US10550099	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	2/4/2020	11/7/2020	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=429875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=429875&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			154732821	434319303							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
870544	CC(C)Cn1nccc1-c1ccnc(N[C@@H](C)c2cc3cc(Cl)ccc3[nH]c2=O)n1 |r|	InChI=1S/C22H23ClN6O/c1-13(2)12-29-20(7-9-25-29)19-6-8-24-22(28-19)26-14(3)17-11-15-10-16(23)4-5-18(15)27-21(17)30/h4-11,13-14H,12H2,1-3H3,(H,27,30)(H,24,26,28)	MECQRGDQZVETIR-UHFFFAOYSA-N	429877	US10550099, Compound I-85	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 550							US Patent		10.7270/Q2HT2RR8		aid1804139	US10550099	Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W	2/4/2020	11/7/2020	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=429877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=429877&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			154732822	434319304							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
900088	FC1(F)CC(C1)NC(=O)C(N(C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N)c1cccc2cn[nH]c12)c1ccccc1Cl |r|	InChI=1S/C30H24ClF2N7O3/c31-21-6-2-1-5-20(21)27(28(42)37-19-13-30(32,33)14-19)40(22-7-3-4-18-16-36-38-26(18)22)29(43)23-8-9-25(41)39(23)24-12-17(15-34)10-11-35-24/h1-7,10-12,16,19,23,27H,8-9,13-14H2,(H,36,38)(H,37,42)	JVKSHAPFLQYINL-UHFFFAOYSA-N	441993	US10717764, Compound 186::US10640534, Compound 186	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q24Q7Z1S		aid1804385	US10640534	Popovici-Muller, J; Lemieux, RM; Travins, J; Cai, Z; Cui, D; Zhou, D	5/5/2020	1/18/2021	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=441993	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=441993&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			135209447	475744745							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
917378	Fc1cc(cc2cn[nH]c12)N([C@H](C(=O)NC1CCC(F)(F)CC1)c1ccccc1Cl)C(=O)[C@@H]1COC(=O)N1c1cc(ccn1)C#N |r|	InChI=1S/C31H25ClF3N7O4/c32-22-4-2-1-3-21(22)27(28(43)39-19-5-8-31(34,35)9-6-19)41(20-12-18-15-38-40-26(18)23(33)13-20)29(44)24-16-46-30(45)42(24)25-11-17(14-36)7-10-37-25/h1-4,7,10-13,15,19,24,27H,5-6,8-9,16H2,(H,38,40)(H,39,43)	YONGOVDOXIFMQX-UHFFFAOYSA-N	448356	US10689414, Compound 136	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<100							US Patent		10.7270/Q2HH6P3B		aid1804515	US10689414	Lemieux, RM; Popovici-Muller, J; Travins, J; Cai, Z; Cui, D; Zhou, D	6/23/2020	2/22/2021	Agios Pharmaceuticals	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=448356	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=448356&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			137435488	440710365							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1182676	COc1cc2[nH]c(=O)c(cc2cc1Cl)C(C)Nc1ccc(C#N)n(C)c1=O	InChI=1S/C19H17ClN4O3/c1-10(22-15-5-4-12(9-21)24(2)19(15)26)13-6-11-7-14(20)17(27-3)8-16(11)23-18(13)25/h4-8,10,22H,1-3H3,(H,23,25)	NSSCFMGYDFCYNL-UHFFFAOYSA-N	550719	US11376246, Cpd ID I-22::US11576906, Compound I-22::US11311527, Cpd ID I-22	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2V69NS1		aid1806638	US11376246	Kelly, PF; Collis, A; Davis, J; Walker, D; Ashwell, S; Thomson, B; Lu, W	7/5/2022	10/5/2022	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=550719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=550719&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			164607410	469794718							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1182680	CC(Nc1ccc(C#N)n(C)c1=O)c1cc2cc(Cl)c(OCc3ccccn3)cc2[nH]c1=O	InChI=1S/C24H20ClN5O3/c1-14(28-20-7-6-17(12-26)30(2)24(20)32)18-9-15-10-19(25)22(11-21(15)29-23(18)31)33-13-16-5-3-4-8-27-16/h3-11,14,28H,13H2,1-2H3,(H,29,31)	PJBUFTGEHWYEER-UHFFFAOYSA-N	550721	US11376246, Cpd ID I-25::US11576906, Compound I-25e::US11311527, Cpd ID I-25	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		 55							US Patent		10.7270/Q2V69NS1		aid1806638	US11376246	Kelly, PF; Collis, A; Davis, J; Walker, D; Ashwell, S; Thomson, B; Lu, W	7/5/2022	10/5/2022	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=550721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=550721&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			164607411	469794720							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
1182686	CC(C)Oc1cc2[nH]c(=O)c(cc2cc1Cl)[C@H](C)Nc1ccc(C#N)n(C)c1=O |r|	InChI=1S/C21H21ClN4O3/c1-11(2)29-19-9-18-13(8-16(19)22)7-15(20(27)25-18)12(3)24-17-6-5-14(10-23)26(4)21(17)28/h5-9,11-12,24H,1-4H3,(H,25,27)	HPOPOVVUDKGCAN-UHFFFAOYSA-N	550724	US11376246, Cpd ID I-29::US11576906, Compound I-29::US11311527, Cpd ID I-29	Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]	Homo sapiens		<10							US Patent		10.7270/Q2V69NS1		aid1806638	US11376246	Kelly, PF; Collis, A; Davis, J; Walker, D; Ashwell, S; Thomson, B; Lu, W	7/5/2022	10/5/2022	Forma Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=550724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=357&target=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=550724&enzyme=Isocitrate+dehydrogenase+%5BNADP%5D+cytoplasmic+%5BR132H%5D&column=ki&startPg=0&Increment=50&submit=Search			164607412	469794723							1	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL	9YHA,8HB9,6VG0,6VEI,6U4J,6Q6F,6O2Z,6O2Y,6ADG,5LGE,4XS3,4XRX,4UMY,4UMX,4KZO,4I3L,4I3K,3MAS,3MAR,3MAP,3INM,9B81,8T7O,8T7N,6B0Z,5TQH,5SVF,5SUN,5DE1	Isocitrate dehydrogenase [NADP] cytoplasmic	IDHC_HUMAN	O75874	Q567U4 Q6FHQ6 Q7Z3V0 Q93090 Q9NTJ9 Q9UKW8